EPEK | Ectopic Pregnancy Knowledgebase

Gene: nitric oxide synthase 2

Gene Information
Official Symbol	NOS2
NCBI Gene Identifier	NCBI: 4843
Gene Name	nitric oxide synthase 2
UniProt Symbol	P35228
ENSEMBL ID	ENSG00000007171
Protein Class	oxidoreductase
KEGG ID	hsa:4843
KEGG Pathway	Metabolic pathways, Pathways in cancer, Pathways of neurodegeneration, Tuberculosis, HIF-1 signaling pathway, Amoebiasis, Toxoplasmosis, Amyotrophic lateral sclerosis, Calcium signaling pathway, Leishmaniasis, Alzheimer disease, Chagas disease, Small cell lung cancer, Pertussis, Apelin signaling pathway, Relaxin signaling pathway, Peroxisome, Arginine and proline metabolism, Arginine biosynthesis

Ontologies

Ontology Type	Accession	Ontology Term
Biological process	GO:0007165 , GO:0006950 , GO:0002376 , GO:0006810 , GO:0042592 , GO:0006464 , GO:0009058 , GO:0034641 , GO:0009056 , GO:0044281 , GO:0003013 , GO:0015031 , GO:0006520 , GO:0006605	signal transduction , response to stress , immune system process , transport , homeostatic process , cellular protein modification process , biosynthetic process , cellular nitrogen compound metabolic process , catabolic process , small molecule metabolic process , circulatory system process , protein transport , cellular amino acid metabolic process , protein targeting
Molecular function	GO:0043167 , GO:0016491	ion binding , oxidoreductase activity
Cellular component	GO:0005623 , GO:0005622 , GO:0043226 , GO:0005737 , GO:0005886 , GO:0005634 , GO:0005829 , GO:0005856 , GO:0005777	cell , intracellular , organelle , cytoplasm , plasma membrane , nucleus , cytosol , cytoskeleton , peroxisome

Information on gene expression associated with ectopic pregnancy

Literature identifier	Biospecimen	Technique used to ascertain differential expression	Regulation	Fold level change	p-value	Control group	Ectopic group	Maternal factors	Expression Type
PMID: 19482272	Fallopian tube	qPCR	Up	-	<0.05	Pseudopregnant	Ectopic pregnancy	-	Transcriptome
PMID: 22425195	Fallopian tube	qRT PCR	Up	-	<0.05	Pseudopregnant	Implantation site	-	Transcriptome
PMID: 22425195	Fallopian tube	Immunohistochemistry	Up	-	<0.05	Pseudopregnant	Implantation site	-	Proteome

DISCLAIMER

EPEK is a comprehensive knowledgebase of expression data relevant to ectopic pregnancy in humans that has been collated and curated from the published scientific literature. We are not liable for any inaccuracies or omissions of any expression data or published scientific literature pertaining to ectopic pregnancy, and users are recommended to use their own discretion while utilizing our resource. The primary goal of developing this resource is to facilitate basic research on ectopic pregnancy in humans, and it does not necessarily reflect the views or objectives of our employers or funders.