Gene: signal transducer and activator of transcription 3


Gene Information
Official SymbolSTAT3
NCBI Gene IdentifierNCBI: 6774
Gene Namesignal transducer and activator of transcription 3
UniProt SymbolP40763
ENSEMBL IDENSG00000168610
Protein ClassDNA-binding transcription factor
KEGG ID hsa:6774
KEGG PathwayPathways in cancer, Human cytomegalovirus infection, Chemical carcinogenesis, JAK-STAT signaling pathway, Lipid and atherosclerosis, Proteoglycans in cancer, HIF-1 signaling pathway, Th17 cell differentiation, Coronavirus disease, Chemokine signaling pathway, MicroRNAs in cancer, Toxoplasmosis, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Inflammatory bowel disease, AGE-RAGE signaling pathway in diabetic complications, EGFR tyrosine kinase inhibitor resistance, Hepatitis C, Signaling pathways regulating pluripotency of stem cells, Hepatitis B, FoxO signaling pathway, Measles, Necroptosis, Non-small cell lung cancer, Adipocytokine signaling pathway, Insulin resistance, Growth hormone synthesis, secretion and action, Pancreatic cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Viral carcinogenesis, Prolactin signaling pathway, Acute myeloid leukemia


Ontologies
Ontology TypeAccessionOntology Term
Biological processGO:0007165, GO:0048856, GO:0006950, GO:0002376, GO:0006810, GO:0030154, GO:0042592, GO:0000003, GO:0009058, GO:0007267, GO:0034641, GO:0015031, GO:0044403, GO:0061024, GO:0008283, GO:0007568, GO:0007005, GO:0006913signal transduction, anatomical structure development, response to stress, immune system process, transport, cell differentiation, homeostatic process, reproduction, biosynthetic process, cell-cell signaling, cellular nitrogen compound metabolic process, protein transport, symbiotic process, membrane organization, cell population proliferation, aging, mitochondrion organization, nucleocytoplasmic transport
Molecular functionGO:0019899, GO:0003677, GO:0003700, GO:0008134enzyme binding, DNA binding, DNA-binding transcription factor activity, transcription factor binding
Cellular componentGO:0005623, GO:0005622, GO:0043226, GO:0005737, GO:0005886, GO:0005634, GO:0032991, GO:0005829, GO:0005654, GO:0005739, GO:0005694, GO:0000228cell, intracellular, organelle, cytoplasm, plasma membrane, nucleus, protein-containing complex, cytosol, nucleoplasm, mitochondrion, chromosome, nuclear chromosome

Information on gene expression associated with ectopic pregnancy
Literature identifierBiospecimenTechnique used to ascertain differential expressionRegulationFold level changep-valueControl groupEctopic groupMaternal factorsExpression Type
PMID: 27511901Fallopian tubeqPCRUp-0.0006Non-pregnantEctopic pregnancy-Transcriptome
PMID: 27511901Fallopian tubeImmunohistochemistryUp-0.0007Non-pregnantEctopic pregnancy-Proteome

DISCLAIMER

EPEK is a comprehensive knowledgebase of expression data relevant to ectopic pregnancy in humans that has been collated and curated from the published scientific literature. We are not liable for any inaccuracies or omissions of any expression data or published scientific literature pertaining to ectopic pregnancy, and users are recommended to use their own discretion while utilizing our resource. The primary goal of developing this resource is to facilitate basic research on ectopic pregnancy in humans, and it does not necessarily reflect the views or objectives of our employers or funders.