Tick species	NCBI TaxID	UniProt Accession	Protein Name	Gene	Length (in aa)	Status	Subcellular Location	GO Biological Process	GO Molecular Function	GO Cellular Component	Keywords	PDB	Function
Amblyomma gervaisi	1987576	A0A977XUP1	Cytochrome c oxidase subunit 1	COX1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma gervaisi	1987576	A0A977TPU8	NADH dehydrogenase subunit 6	ND6	141	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Amblyomma gervaisi	1987576	A0A977TPU0	ATP synthase subunit 8	ATP8	51	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Amblyomma gervaisi	1987576	A0A977XVI4	Cytochrome b	CYTB	358	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Amblyomma gervaisi	1987576	A0A977TQ20	NADH-ubiquinone oxidoreductase chain 4	ND4	440	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma gervaisi	1987576	A0A977TQ13	NADH-ubiquinone oxidoreductase chain 4L	ND4L	91	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Amblyomma gervaisi	1987576	A0A977XWG9	NADH-ubiquinone oxidoreductase chain 2	ND2	320	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma gervaisi	1987576	A0A977TPV1	Cytochrome c oxidase subunit 3	COX3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma gervaisi	1987576	A0A977TPU9	NADH-ubiquinone oxidoreductase chain 5	ND5	550	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma gervaisi	1987576	A0A977TPU5	NADH-ubiquinone oxidoreductase chain 3	ND3	115	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Amblyomma gervaisi	1987576	A0A977TPU4	NADH-ubiquinone oxidoreductase chain 1	ND1	330	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma gervaisi	1987576	A0A977TPT6	Cytochrome c oxidase subunit 2	COX2	225	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma gervaisi	1987576	A0A977TPZ1	ATP synthase subunit a	ATP6	220	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Amblyomma integrum	1977407	A0A6M4EJ88	Cytochrome c oxidase subunit 1	CO1	175	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma javanense	1658007	A0A4Y5UC45	NADH-ubiquinone oxidoreductase chain 4L	ND4L	91	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Amblyomma javanense	1658007	A0A4Y5UC47	NADH dehydrogenase subunit 6	ND6	141	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Amblyomma javanense	1658007	A0A4Y5UBW7	ATP synthase F0 subunit 8	ATP8	52	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Amblyomma javanense	1658007	A0A4Y5UCY9	NADH-ubiquinone oxidoreductase chain 4	ND4	441	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma javanense	1658007	A0A4Y5UCT7	NADH-ubiquinone oxidoreductase chain 5	ND5	551	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma javanense	1658007	A0A4Y5UCC7	NADH-ubiquinone oxidoreductase chain 1	ND1	318	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma javanense	1658007	A0A4Y5UC42	Cytochrome c oxidase subunit 2	COX2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma javanense	1658007	A0A4Y5UBZ0	ATP synthase subunit a	ATP6	220	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Amblyomma javanense	1658007	A0A4Y5UBY8	Cytochrome c oxidase subunit 3	COX3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma javanense	1658007	A0A4Y5UBY6	NADH-ubiquinone oxidoreductase chain 3	ND3	113	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Amblyomma javanense	1658007	A0A4Y5UBY2	NADH-ubiquinone oxidoreductase chain 2	ND2	320	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma javanense	1658007	A0A4Y5UBX8	Cytochrome b	CYTB	357	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Amblyomma javanense	1658007	A0A4Y5UC36	Cytochrome c oxidase subunit 1	COX1	513	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma javanense	1658007	A0A4D6D1N4	Cytochrome c oxidase subunit 1	COI	283	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma testudinarium	375577	A0A7R6VSD8	ATP synthase subunit a	ATP6	220	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Amblyomma testudinarium	375577	A0A7U3LL15	Cytochrome b	CYB	358	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Amblyomma testudinarium	375577	A0A7U3LL18	NADH-ubiquinone oxidoreductase chain 4	ND4	441	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma testudinarium	375577	A0A7U3LLX1	NADH-ubiquinone oxidoreductase chain 5	ND5	551	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma testudinarium	375577	A0A7U3LM23	NADH-ubiquinone oxidoreductase chain 3	ND3	113	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Amblyomma testudinarium	375577	A0A7U3QYB4	NADH-ubiquinone oxidoreductase chain 4L	ND4L	91	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Amblyomma testudinarium	375577	A0A6M3RHZ0	NADH dehydrogenase subunit 6	ND6	142	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Amblyomma testudinarium	375577	A0A7U3QZ21	NADH-ubiquinone oxidoreductase chain 1	ND1	335	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma testudinarium	375577	A0A7R6VSB5	NADH-ubiquinone oxidoreductase chain 2	ND2	320	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma testudinarium	375577	A0A6M3RNS0	ATP synthase F0 subunit 8	ATP8	52	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Amblyomma testudinarium	375577	A0A7R6VSB9	ATP synthase subunit 8	ATP8	52	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Amblyomma testudinarium	375577	A0A7U3LL51	NADH dehydrogenase subunit 6	ND6	143	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Amblyomma testudinarium	375577	A0A7U3QYY9	Cytochrome c oxidase subunit 3	CO3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma testudinarium	375577	A0A6M3RVF1	NADH-ubiquinone oxidoreductase chain 3	ND3	113	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Amblyomma testudinarium	375577	A0A7R6VSB0	Cytochrome c oxidase subunit 2	CO2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma testudinarium	375577	A0A6M3RKS9	Cytochrome c oxidase subunit 3	COX3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma testudinarium	375577	A0A6M3RNN7	NADH-ubiquinone oxidoreductase chain 1	ND1	318	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma testudinarium	375577	P84814	Opioid peptide		9	Reviewed		regulation of sensory perception of pain	opioid peptide activity		Direct protein sequencing | Opioid peptide		Has opiate-like activity. Decreases nociception-related behavior in a dose dependent fashion when administered to mice. May play a role in down-regulating the host defense and immune response during feeding
Amblyomma testudinarium	375577	A0A6M3RHX2	Cytochrome c oxidase subunit 1	COX1	513	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma testudinarium	375577	A0A7G0WJ99	Cytochrome c oxidase subunit 1	COI	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma testudinarium	375577	A0A7G0WMI2	Cytochrome c oxidase subunit 1	COI	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma testudinarium	375577	A0A7G0XN95	Cytochrome c oxidase subunit 1	COI	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma testudinarium	375577	A0A7R6VSB4	Cytochrome c oxidase subunit 1	CO1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma testudinarium	375577	A0A6M3RX00	NADH-ubiquinone oxidoreductase chain 4	ND4	441	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	G protein-coupled receptor activity | NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma testudinarium	375577	A0A6M3RI49	Cytochrome c oxidase subunit 2	COX2	226	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Amblyomma testudinarium	375577	A0A6M3RI55	Cytochrome b	CYTB	357	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Amblyomma testudinarium	375577	A0A6M3RI67	ATP synthase subunit a	ATP6	220	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Amblyomma testudinarium	375577	A0A6M3RHY5	NADH-ubiquinone oxidoreductase chain 5	ND5	551	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma testudinarium	375577	A0A6M3RIA3	NADH-ubiquinone oxidoreductase chain 2	ND2	320	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Amblyomma testudinarium	375577	A0A6M3RIB0	NADH-ubiquinone oxidoreductase chain 4L	ND4L	91	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Argas reflexus	34604	A0A7S9SM74	Cytochrome c oxidase subunit 1	COX1	186	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Argas reflexus	34604	A0A7S9SM87	Cytochrome c oxidase subunit 1	COX1	196	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Argas reflexus	34604	Q5GQ85	Allergen Arg r 1		159	Reviewed	Secreted	symbiont-mediated perturbation of host defenses	amine binding	extracellular region	3D-structure | Allergen | Direct protein sequencing | Disulfide bond | Secreted | Signal	2X45 | 2X46	
Dermacentor auratus	1256036	A0A8A2H8N6	Cytochrome c oxidase subunit 3	COX3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Dermacentor auratus	1256036	A0A8A2H8W5	NADH dehydrogenase subunit 6	ND6	144	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Dermacentor auratus	1256036	A0A8A2H951	NADH-ubiquinone oxidoreductase chain 1	ND1	306	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Dermacentor auratus	1256036	A0A8A2H8X2	Cytochrome b	CYTB	360	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Dermacentor auratus	1256036	A0A8A2H8W7	Cytochrome c oxidase subunit 2	COX2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Dermacentor auratus	1256036	A0A8A2H918	ATP synthase F0 subunit 8	ATP8	53	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Dermacentor auratus	1256036	A0A8A2H8W6	NADH-ubiquinone oxidoreductase chain 4	ND4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Dermacentor auratus	1256036	A0A8A2H8H8	NADH-ubiquinone oxidoreductase chain 3	ND3	114	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Dermacentor auratus	1256036	A0A8A2H7X4	NADH-ubiquinone oxidoreductase chain 5	ND5	552	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Dermacentor auratus	1256036	A0A8A2H855	NADH-ubiquinone oxidoreductase chain 4L	ND4L	91	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Dermacentor auratus	1256036	A0A8A2H854	NADH-ubiquinone oxidoreductase chain 2	ND2	319	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Dermacentor auratus	1256036	A0A8A2H8W1	Cytochrome c oxidase subunit 1	COX1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Dermacentor auratus	1256036	A0A7U0L2L0	Cytochrome c oxidase subunit 1	COX1	185	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Dermacentor auratus	1256036	A0A6M3RM84	Cytochrome c oxidase subunit 1	COX1	235	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Dermacentor auratus	1256036	A0A3G2CK31	Cytochrome c oxidase subunit 1	COI	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Dermacentor auratus	1256036	A0A8A2H8F2	ATP synthase subunit a	ATP6	221	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Haemaphysalis bispinosa	1340770	A0A5B9R1T8	Cytochrome c oxidase subunit 1	COI	175	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A5B9R305	Cytochrome c oxidase subunit 1	COI	206	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A5B9R3Y1	Cytochrome c oxidase subunit 1	COI	198	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A5B9RAL4	Cytochrome c oxidase subunit 1	COI	197	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A5B9RAM3	Cytochrome c oxidase subunit 1	COI	206	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A089VKV7	Haemathrin 1		78	Unreviewed					Signal		
Haemaphysalis bispinosa	1340770	A0A7S9AU96	Cytochrome c oxidase subunit 1	COXI	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A089X5A5	Haemathrin 2		78	Unreviewed					Signal		
Haemaphysalis bispinosa	1340770	A0A8E4H9K7	Bispinosin	bsn	73	Unreviewed	Secreted	defense response to bacterium		extracellular region	Antibiotic | Antimicrobial | Disulfide bond | Secreted | Signal		
Haemaphysalis bispinosa	1340770	A0A5B9R1Q9	Cytochrome c oxidase subunit 1	COI	197	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A5B9RB19	Cytochrome c oxidase subunit 1	COI	198	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A5B9R1G6	Cytochrome c oxidase subunit 1	COI	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A5B9QYV5	Cytochrome c oxidase subunit 1	COI	197	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A4P8GKG1	Cytochrome c oxidase subunit 1	CO1	181	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A4V1E979	Cytochrome c oxidase subunit 1	CO1	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A4P8GP42	Cytochrome c oxidase subunit 1	CO1	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A4P8GMZ3	Cytochrome c oxidase subunit 1	CO1	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A4P8GM20	Cytochrome c oxidase subunit 1	CO1	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A4P8GLD1	Cytochrome c oxidase subunit 1	CO1	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A4P8GL93	Cytochrome c oxidase subunit 1	CO1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A4P8GKH2	Cytochrome c oxidase subunit 1	CO1	217	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A4P8GKG9	Cytochrome c oxidase subunit 1	CO1	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A482NAE1	Cytochrome c oxidase subunit 1	COI	207	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis bispinosa	1340770	A0A5B9QZ01	Cytochrome c oxidase subunit 1	COI	202	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis cornigera	1325867	A0A976R610	ATP synthase subunit a	ATP6	221	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Haemaphysalis cornigera	1325867	A0A976R613	NADH-ubiquinone oxidoreductase chain 3	ND3	112	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Haemaphysalis cornigera	1325867	A0A976R6R5	NADH-ubiquinone oxidoreductase chain 1	ND1	318	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis cornigera	1325867	A0A976R7I6	Cytochrome c oxidase subunit 3	COX3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis cornigera	1325867	A0A976R4K2	ATP synthase F0 subunit 8	ATP8	51	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Haemaphysalis cornigera	1325867	A0A976MZH6	NADH-ubiquinone oxidoreductase chain 4L	ND4L	91	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Haemaphysalis cornigera	1325867	A0A976MZ26	NADH dehydrogenase subunit 6	ND6	143	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Haemaphysalis cornigera	1325867	A0A976MZB3	Cytochrome b	CYTB	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Haemaphysalis cornigera	1325867	A0A976MYW4	NADH-ubiquinone oxidoreductase chain 1	ND1	318	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis cornigera	1325867	A0A976MYX2	NADH-ubiquinone oxidoreductase chain 4	ND4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis cornigera	1325867	A0A976MYP5	NADH-ubiquinone oxidoreductase chain 5	ND5	551	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis cornigera	1325867	A0A976MYN9	NADH-ubiquinone oxidoreductase chain 3	ND3	112	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Haemaphysalis cornigera	1325867	A0A976MYI5	Cytochrome c oxidase subunit 2	COX2	225	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis cornigera	1325867	A0A976MY32	Cytochrome b	CYTB	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Haemaphysalis cornigera	1325867	A0A976MYK9	Cytochrome c oxidase subunit 1	COX1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis cornigera	1325867	A0A976MYZ0	NADH-ubiquinone oxidoreductase chain 2	ND2	319	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis doenitzi	1048531	A0AAU8BS05	Cytochrome P450		213	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane		heme binding | iron ion binding | monooxygenase activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	endoplasmic reticulum membrane	Endoplasmic reticulum | Heme | Iron | Membrane | Metal-binding | Microsome | Monooxygenase | Oxidoreductase		
Haemaphysalis doenitzi	1048531	J7I7M0	17 beta-hydroxysteroid dehydrogenase		195	Unreviewed	Endoplasmic reticulum		oxidoreductase activity	endoplasmic reticulum	Oxidoreductase		
Haemaphysalis doenitzi	1048531	I1WDI6	Heat shock protein	hsp	197	Unreviewed			ATP binding | ATP hydrolysis activity | ATP-dependent protein folding chaperone | unfolded protein binding		ATP-binding | Chaperone | Nucleotide-binding | Stress response		
Haemaphysalis doenitzi	1048531	I1WDI3	Translation elongation factor EF1-alpha		205	Unreviewed			GTP binding | GTPase activity | translation elongation factor activity		Elongation factor | GTP-binding | Nucleotide-binding | Phosphoprotein | Protein biosynthesis		
Haemaphysalis doenitzi	1048531	A0AAU8BT11	Catechol O-methyltransferase domain-containing protein 1		225	Unreviewed		methylation	O-methyltransferase activity | S-adenosylmethionine-dependent methyltransferase activity		Methyltransferase | S-adenosyl-L-methionine | Transferase		
Haemaphysalis doenitzi	1048531	A0A650AWF6	Serpin	S1	67	Unreviewed							
Haemaphysalis doenitzi	1048531	A0AAU8BTU1	Programmed cell death protein 4		456	Unreviewed	Cytoplasm	negative regulation of DNA-templated transcription		cytosol | nucleus	Cytoplasm | Nucleus | Repeat		
Haemaphysalis doenitzi	1048531	A0AAU8BV63	Nitric oxide synthase-interacting protein homolog		295	Unreviewed	Nucleus		ubiquitin protein ligase activity	nucleus	Coiled coil | Nucleus		
Haemaphysalis doenitzi	1048531	A0AAU8BUX0	Eukaryotic peptide chain release factor subunit 1		441	Unreviewed	Cytoplasm		translation release factor activity	cytosol	Cytoplasm | Protein biosynthesis		Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA
Haemaphysalis doenitzi	1048531	A0AA96KFZ9	glutathione transferase		230	Unreviewed		glutathione metabolic process	glutathione transferase activity		Transferase		
Haemaphysalis doenitzi	1048531	I1WDH7	Cytochrome c oxidase subunit 1	COI	175	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis doenitzi	1048531	C0HMC7	Doenitin-1		141	Reviewed	Secreted		serine-type endopeptidase inhibitor activity | toxin activity	extracellular space	Blood coagulation cascade inhibiting toxin | Disulfide bond | Hemostasis impairing toxin | Protease inhibitor | Repeat | Secreted | Serine protease inhibitor | Signal | Toxin		Anticoagulant protein that targets host intrinsic blood coagulation pathway (PubMed:36032296). Inhibits host fibrinogen coagulation (PubMed:36032296). Inhibits host thrombin (F2), cathepsin G (CTSG) but not trypsin (PubMed:36032296). May play a role in keeping the blood meal in liquid form in the gut (PubMed:36032296)
Haemaphysalis doenitzi	1048531	A0A650AWF5	Serpin	S2	45	Unreviewed							
Haemaphysalis flava	181088	A0A160DA52	Cystatin		131	Unreviewed	Secreted		cysteine-type endopeptidase inhibitor activity	cytoplasm | extracellular space | vesicle	Protease inhibitor | Secreted | Signal | Thiol protease inhibitor		
Haemaphysalis flava	181088	A0A0S2CCT2	Serpin 2		398	Unreviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Glycoprotein | Protease inhibitor | Secreted | Serine protease inhibitor | Signal		
Haemaphysalis flava	181088	A0A0M3TC17	AV422	AV422	231	Unreviewed					Signal		
Haemaphysalis flava	181088	Q76LQ7	Cytochrome c oxidase subunit 3	COIII	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A097CK67	Actin		376	Unreviewed	Cytoplasm, cytoskeleton	anatomical structure formation involved in morphogenesis | cell development	ATP binding | hydrolase activity	cytoskeleton	Acetylation | ATP-binding | Cytoplasm | Cytoskeleton | Hydrolase | Nucleotide-binding | Oxidation		
Haemaphysalis flava	181088	A0A097CK65	Longipain		340	Unreviewed		proteolysis	cysteine-type endopeptidase activity		Disulfide bond | Hydrolase | Protease | Signal | Thiol protease | Zymogen		
Haemaphysalis flava	181088	Q76LR2	NADH-ubiquinone oxidoreductase chain 2	ND2	319	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	Q76LR0	Cytochrome c oxidase subunit 2	COII	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	Q76LQ8	ATP synthase subunit a	ATP6	221	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Haemaphysalis flava	181088	Q76LQ6	NADH-ubiquinone oxidoreductase chain 3	ND3	112	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Haemaphysalis flava	181088	A0A7T1C683	NADH-ubiquinone oxidoreductase chain 4	ND4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	Q76LQ4	NADH-ubiquinone oxidoreductase chain 5	ND5	551	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	Q76LQ3	NADH-ubiquinone oxidoreductase chain 4	ND4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	Q76LQ2	NADH-ubiquinone oxidoreductase chain 4L	ND4L	91	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Haemaphysalis flava	181088	Q76LQ0	Cytochrome b	cytb	355	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Haemaphysalis flava	181088	Q6I7N4	NADH-ubiquinone oxidoreductase chain 2	ND2	319	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	A0A8E4JCY1	Ferritin		199	Unreviewed		intracellular iron ion homeostasis | iron ion transport	ferric iron binding | ferrous iron binding | ferroxidase activity	cytoplasm	Iron | Iron storage | Metal-binding | Oxidoreductase | Signal		Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation
Haemaphysalis flava	181088	A0A7T1FVC2	NADH-ubiquinone oxidoreductase chain 2	ND2	319	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	A0A7T1FV32	NADH-ubiquinone oxidoreductase chain 5	ND5	551	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	A0A160DAC4	Haemalin		140	Unreviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Disulfide bond | Protease inhibitor | Repeat | Secreted | Serine protease inhibitor | Signal		
Haemaphysalis flava	181088	Q76LQ5	NADH-ubiquinone oxidoreductase chain 1	ND1	315	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	A0A1L5L8R3	Heat shock protein 70-8235	HSP70-8235	636	Unreviewed		response to stress	ATP binding | ATP-dependent protein folding chaperone		ATP-binding | Nucleotide-binding | Stress response		
Haemaphysalis flava	181088	Q6I7N3	Cytochrome oxidase subunit I	COI	14	Unreviewed					Mitochondrion		
Haemaphysalis flava	181088	A0A346JM05	Vitellogenin-1	Vg-1	1693	Unreviewed			lipid transporter activity | nutrient reservoir activity		Disulfide bond | Glycoprotein | Signal | Storage protein		
Haemaphysalis flava	181088	Q76LQ9	ATP synthase F0 subunit 8	ATP8	53	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Haemaphysalis flava	181088	Q76LQ1	NADH dehydrogenase 6	ND6	146	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Haemaphysalis flava	181088	A0A8X8MG03	Vitellin-a	Vn-a	1879	Unreviewed			lipid transporter activity | nutrient reservoir activity		Disulfide bond | Glycoprotein | Signal | Storage protein		
Haemaphysalis flava	181088	A0A8F1NJF7	Neutrophil elastase inhibitor		102	Unreviewed					Signal		
Haemaphysalis flava	181088	A0A8F1NJE0	Neutrophil elastase inhibitor		102	Unreviewed					Signal		
Haemaphysalis flava	181088	A0A7T1C680	NADH dehydrogenase subunit 6	ND6	146	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Haemaphysalis flava	181088	A0A6N0USP0	Heat shock protein 70 b2		634	Unreviewed		response to stress	ATP binding | ATP-dependent protein folding chaperone		ATP-binding | Nucleotide-binding | Stress response		
Haemaphysalis flava	181088	A0A6M3YRY3	Cystatin protein		129	Unreviewed	Secreted		cysteine-type endopeptidase inhibitor activity	cytoplasm | extracellular space | vesicle	Protease inhibitor | Secreted | Signal | Thiol protease inhibitor		
Haemaphysalis flava	181088	A0A6B9DA14	Cystatin	cyst-1	142	Unreviewed	Secreted		cysteine-type endopeptidase inhibitor activity	cytoplasm | extracellular space | vesicle	Protease inhibitor | Secreted | Signal | Thiol protease inhibitor		
Haemaphysalis flava	181088	A0A1Z2RPA8	Heat shock protein 70-8804	HSP70-8804	639	Unreviewed		response to stress	ATP binding | ATP-dependent protein folding chaperone		ATP-binding | Nucleotide-binding | Stress response		
Haemaphysalis flava	181088	A0A5Q0V3S2	Glycine rich protein		131	Unreviewed					Signal		
Haemaphysalis flava	181088	A0A4V1GQ44	Cathepsin L-like cysteine proteinase A		333	Unreviewed		proteolysis	cysteine-type peptidase activity		Disulfide bond | Hydrolase | Protease | Signal | Thiol protease | Zymogen		
Haemaphysalis flava	181088	A0A4P9D0Y2	Serine protease		463	Unreviewed		proteolysis	serine-type endopeptidase activity		Disulfide bond | Hydrolase | Protease | Serine protease | Signal		
Haemaphysalis flava	181088	A0A455LP86	Cathepsin L		346	Unreviewed		proteolysis	cysteine-type peptidase activity		Disulfide bond | Hydrolase | Protease | Signal | Thiol protease		
Haemaphysalis flava	181088	A0A411HE54	Cathepsin L-like cysteine protein		335	Unreviewed		proteolysis	cysteine-type peptidase activity		Disulfide bond | Hydrolase | Protease | Signal | Thiol protease | Zymogen		
Haemaphysalis flava	181088	A0A411G179	Vitellogenin	Vg	1965	Unreviewed			lipid transporter activity | nutrient reservoir activity		Disulfide bond | Glycoprotein | Signal | Storage protein		
Haemaphysalis flava	181088	A0A3G6VF56	Cystatin		141	Unreviewed	Secreted		cysteine-type endopeptidase inhibitor activity	cytoplasm | extracellular space | vesicle	Protease inhibitor | Secreted | Signal | Thiol protease inhibitor		
Haemaphysalis flava	181088	A0A346JM08	Vitellogenin-B	Vg-B	3191	Unreviewed			lipid transporter activity | nutrient reservoir activity		Disulfide bond | Glycoprotein | Signal | Storage protein		
Haemaphysalis flava	181088	A0A346JM07	Vitellogenin-3	Vg-3	1533	Unreviewed			lipid transporter activity | nutrient reservoir activity		Disulfide bond | Glycoprotein | Signal | Storage protein		
Haemaphysalis flava	181088	A0A346JM06	Vitellogenin-2	Vg-2	1557	Unreviewed			lipid transporter activity | nutrient reservoir activity		Disulfide bond | Glycoprotein | Signal | Storage protein		
Haemaphysalis flava	181088	A0A5B9BYB0	Cysteine-rich protein		166	Unreviewed					Signal		
Haemaphysalis flava	181088	A0A7T1C678	NADH-ubiquinone oxidoreductase chain 1	ND1	315	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	A0A8E4NKH1	Ferritin		174	Unreviewed		intracellular iron ion homeostasis | iron ion transport	ferric iron binding | ferrous iron binding | ferroxidase activity	cytoplasm	Iron | Iron storage | Metal-binding | Oxidoreductase		Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation
Haemaphysalis flava	181088	A0A6B9XKF3	Cytochrome c oxidase subunit 1		219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TBX1	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TBR6	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TBA4	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TB79	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TB66	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TAJ4	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TAI1	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TAH9	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TAH6	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TC89	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TAB9	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TA41	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TA34	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TA30	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TA21	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TA01	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A6M3W6Q8	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A411ARG7	Cytochrome c oxidase subunit 1	COX1	509	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A3G2CKA5	Cytochrome c oxidase subunit 1	COI	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A2P1DPZ4	Glyceraldehyde-3-phosphate dehydrogenase		333	Unreviewed	Cytoplasm	glucose metabolic process | glyceraldehyde-3-phosphate metabolic process | glycolytic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | NAD binding | NADP binding	cytosol	Cytoplasm | Glycolysis | NAD | Nucleotide-binding | Oxidoreductase		
Haemaphysalis flava	181088	A0A7L8TA71	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TCE8	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TAY8	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A7L8TCW8	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A4P9D2E3	CLIP domain-containing serine protease		406	Unreviewed	Secreted	proteolysis	serine-type endopeptidase activity	extracellular region	Disulfide bond | Hydrolase | Protease | Secreted | Serine protease | Signal		
Haemaphysalis flava	181088	A0A411ARJ3	Cytochrome b	CYTB	355	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Haemaphysalis flava	181088	A0A411ARJ0	NADH-ubiquinone oxidoreductase chain 1	ND1	315	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	A0A7L8TCV8	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A6G6CUG5	Alpha-mannosidase		978	Unreviewed		mannose metabolic process	alpha-mannosidase activity | carbohydrate binding | metal ion binding	lysosome	Disulfide bond | Glycoprotein | Glycosidase | Hydrolase | Metal-binding | Signal | Zinc		
Haemaphysalis flava	181088	A0A2D1QTY8	NADH-ubiquinone oxidoreductase chain 4	nad4	208	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	A0A2D1QTV9	NADH-ubiquinone oxidoreductase chain 4	nad4	208	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	A0A2D1QTV7	NADH-ubiquinone oxidoreductase chain 4	nad4	208	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	A0A2D1QTU9	NADH-ubiquinone oxidoreductase chain 1	nad1	95	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	A0A2D1QTU6	NADH-ubiquinone oxidoreductase chain 1	nad1	95	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	A0A2D1C0A7	Heat shock protein 83		735	Unreviewed	Cytoplasm		ATP binding | ATP hydrolysis activity | ATP-dependent protein folding chaperone | unfolded protein binding	cytoplasm | protein folding chaperone complex	ATP-binding | Chaperone | Coiled coil | Cytoplasm | Nucleotide-binding | Stress response		
Haemaphysalis flava	181088	A0A411ARI5	NADH-ubiquinone oxidoreductase chain 2	ND2	319	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis flava	181088	A0A1L5L8Q9	Heat shock protein 70-4468	HSP70-4468	660	Unreviewed	Endoplasmic reticulum lumen		ATP binding | ATP-dependent protein folding chaperone	endoplasmic reticulum lumen	ATP-binding | Coiled coil | Endoplasmic reticulum | Nucleotide-binding | Signal | Stress response		
Haemaphysalis flava	181088	A0A097CK68	Enolase		433	Unreviewed		glycolytic process	magnesium ion binding | phosphopyruvate hydratase activity	phosphopyruvate hydratase complex	Glycolysis | Lyase | Magnesium | Metal-binding		
Haemaphysalis flava	181088	A0A097A1J8	Heat shock 70 kDa protein cognate 4		648	Unreviewed		response to stress	ATP binding | ATP-dependent protein folding chaperone		ATP-binding | Nucleotide-binding | Stress response		
Haemaphysalis flava	181088	A0A077B3N4	Subolesin	4D8	179	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Haemaphysalis flava	181088	W8Q0F2	Cytochrome c oxidase subunit 1	COI	283	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	V5J213	Cytochrome c oxidase subunit 1	COI	235	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	Q76LR1	Cytochrome c oxidase subunit 1	COI	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	G3FSW8	Cytochrome c oxidase subunit 1	COI	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis flava	181088	A0A8F1NJ79	Autophagy protein 5		270	Unreviewed	Cytoplasm | Preautophagosomal structure membrane	apoptotic process | autophagosome assembly | autophagy of mitochondrion | cellular response to nitrogen starvation | immune system process | negative regulation of programmed cell death | piecemeal microautophagy of the nucleus	Atg8-family ligase activity	Atg12-Atg5-Atg16 complex | autophagosome | mitochondria-associated endoplasmic reticulum membrane contact site | phagophore | phagophore assembly site membrane	Acetylation | Apoptosis | Autophagy | Cytoplasm | Immunity | Isopeptide bond | Membrane | Ubl conjugation		Involved in autophagic vesicle formation
Haemaphysalis flava	181088	A0A1L5L8R0	Heat shock protein 70-2393	HSP70-2393	691	Unreviewed			ATP binding | ATP-dependent protein folding chaperone | unfolded protein binding		ATP-binding | Coiled coil | Nucleotide-binding | Stress response		
Haemaphysalis formosensis	1155004	L7PCM9	NADH dehydrogenase subunit 6	ND6	149	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Haemaphysalis formosensis	1155004	L7PCD1	ATP synthase subunit 8	ATP8	53	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Haemaphysalis formosensis	1155004	L7PCU2	NADH-ubiquinone oxidoreductase chain 4L	ND4L	91	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Haemaphysalis formosensis	1155004	L7PCU0	Cytochrome c oxidase subunit 3	CO3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis formosensis	1155004	L7PCT9	NADH-ubiquinone oxidoreductase chain 2	ND2	319	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis formosensis	1155004	L7PCM8	NADH-ubiquinone oxidoreductase chain 3	ND3	112	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Haemaphysalis formosensis	1155004	L7PC67	NADH-ubiquinone oxidoreductase chain 1	ND1	315	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis formosensis	1155004	L7PCK2	ATP synthase subunit a	ATP6	221	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Haemaphysalis formosensis	1155004	L7PCD2	NADH-ubiquinone oxidoreductase chain 5	ND5	551	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis formosensis	1155004	L7PC68	Cytochrome b	CYB	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Haemaphysalis formosensis	1155004	L7PC66	Cytochrome c oxidase subunit 2	CO2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis formosensis	1155004	L7PCM6	Cytochrome c oxidase subunit 1	CO1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis formosensis	1155004	L7PCK3	NADH-ubiquinone oxidoreductase chain 4	ND4	436	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis intermedia	1027255	A0A7S9AUA6	Cytochrome c oxidase subunit 1	COXI	140	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis leachii	44385	A0A889IBE9	Cytochrome c oxidase subunit 1	COX1	184	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis leachii	44385	A0A889IB85	Cytochrome c oxidase subunit 1	COX1	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis leachii	44385	A0A889IB62	Cytochrome c oxidase subunit 1	COX1	216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis leachii	44385	A0A6H0QV07	Cytochrome c oxidase subunit 1	cox1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A9J6GXE7	Ras-related protein Rac1		201	Unreviewed		actin filament bundle assembly | dorsal appendage formation | hemocyte migration | JNK cascade | lamellipodium assembly | melanotic encapsulation of foreign target | mesodermal cell migration | myoblast fusion | phagocytosis, engulfment | positive regulation of wound healing | regulation of adherens junction organization | regulation of axonogenesis | small GTPase-mediated signal transduction | tracheal outgrowth, open tracheal system	GTP binding | GTPase activity | protein kinase binding		GTP-binding | Lipoprotein | Methylation | Nucleotide-binding | Phagocytosis | Prenylation | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6GXA0	Cholesterol side-chain cleavage enzyme, mitochondrial		104	Unreviewed	Mitochondrion inner membrane	C21-steroid hormone biosynthetic process | cellular response to peptide hormone stimulus | cholesterol metabolic process | cortisol metabolic process | glucocorticoid biosynthetic process	cholesterol monooxygenase (side-chain-cleaving) activity | heme binding | iron ion binding	mitochondrial inner membrane	Cholesterol metabolism | Heme | Iron | Lipid metabolism | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Monooxygenase | Oxidoreductase | Reference proteome | Steroid metabolism | Steroidogenesis | Sterol metabolism | Transit peptide		
Haemaphysalis longicornis	44386	A0A9J6GX60	Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1		177	Unreviewed	Membrane	phospholipid biosynthetic process	phosphatidylglycerophosphatase activity | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | phosphoprotein phosphatase activity	cytoplasm | membrane	Hydrolase | Lipid biosynthesis | Lipid metabolism | Membrane | Phospholipid biosynthesis | Phospholipid metabolism | Protein phosphatase | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6GUX7	U8 snoRNA-decapping enzyme		231	Unreviewed	Nucleus, nucleolus | Nucleus, nucleoplasm	mRNA catabolic process | nucleotide metabolic process | sno(s)RNA catabolic process	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity | IDP phosphatase activity | phosphodiesterase decapping endonuclease activity | snoRNA binding	nucleolus | nucleoplasm	Hydrolase | Nucleotide metabolism | Nucleus | Reference proteome | RNA-binding		
Haemaphysalis longicornis	44386	A0A9J6GUU9	Adenylosuccinate lyase		481	Unreviewed		'de novo' AMP biosynthetic process	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	cytosol	Lyase | Purine biosynthesis | Reference proteome		Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate
Haemaphysalis longicornis	44386	A0A9J6GUG5	Presenilin		457	Unreviewed	Endoplasmic reticulum membrane | Golgi apparatus membrane	amyloid-beta formation | calcium ion homeostasis | membrane protein ectodomain proteolysis | Notch signaling pathway | protein processing	aspartic endopeptidase activity, intramembrane cleaving	endoplasmic reticulum membrane | gamma-secretase complex | Golgi membrane	Endoplasmic reticulum | Golgi apparatus | Hydrolase | Membrane | Notch signaling pathway | Protease | Reference proteome | Transmembrane | Transmembrane helix		Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors
Haemaphysalis longicornis	44386	A0A9J6GSM1	IST1 homolog		349	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Cytoplasmic vesicle | Midbody | Nucleus envelope	cell division | protein transport		centrosome | cytoplasmic vesicle | midbody | nuclear envelope	Cell cycle | Cell division | Coiled coil | Cytoplasm | Cytoplasmic vesicle | Cytoskeleton | Nucleus | Phosphoprotein | Reference proteome		ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST
Haemaphysalis longicornis	44386	A0A9J6GS32	Bifunctional glutamate/proline--tRNA ligase		1519	Unreviewed		glutamyl-tRNA aminoacylation | prolyl-tRNA aminoacylation	ATP binding | glutamate-tRNA ligase activity | metal ion binding | proline-tRNA ligase activity | RNA binding	aminoacyl-tRNA synthetase multienzyme complex | cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Coiled coil | Ligase | Metal-binding | Multifunctional enzyme | Nucleotide-binding | Phosphoprotein | Protein biosynthesis | Reference proteome | RNA-binding | Zinc		
Haemaphysalis longicornis	44386	A0A9J6GRV6	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase		1081	Unreviewed	Cytoplasm	innate immune response | NAD+ catabolic process | negative regulation of MyD88-independent toll-like receptor signaling pathway | response to axon injury | signal transduction	NAD+ nucleosidase activity | NAD+ nucleosidase activity, cyclic ADP-ribose generating | signaling adaptor activity	cell body | cytoplasm | dendrite	Cytoplasm | Hydrolase | Immunity | Innate immunity | NAD | Reference proteome | Repeat		
Haemaphysalis longicornis	44386	A0A9J6GRM7	Short-chain specific acyl-CoA dehydrogenase, mitochondrial		409	Unreviewed		butyrate catabolic process | fatty acid beta-oxidation using acyl-CoA dehydrogenase	flavin adenine dinucleotide binding | short-chain fatty acyl-CoA dehydrogenase activity	mitochondrion	FAD | Flavoprotein | Oxidoreductase | Reference proteome		Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains
Haemaphysalis longicornis	44386	A0A9J6GQU0	DNA replication ATP-dependent helicase/nuclease		890	Unreviewed	Nucleus | Chromosome	DNA repair | DNA replication, Okazaki fragment processing | replication fork reversal	4 iron, 4 sulfur cluster binding | 5'-flap endonuclease activity | ATP binding | DNA binding | metal ion binding | single-stranded DNA helicase activity	chromosome | cytoplasm | nucleus	4Fe-4S | ATP-binding | Chromosome | DNA damage | DNA repair | DNA replication | DNA-binding | Helicase | Hydrolase | Iron | Iron-sulfur | Metal-binding | Multifunctional enzyme | Nuclease | Nucleotide-binding | Nucleus | Reference proteome		Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA
Haemaphysalis longicornis	44386	A0A9J6GQS7	Endonuclease III homolog	NTH1	405	Unreviewed	Nucleus | Mitochondrion	base-excision repair, AP site formation | nucleotide-excision repair	4 iron, 4 sulfur cluster binding | class I DNA-(apurinic or apyrimidinic site) endonuclease activity | DNA binding | metal ion binding | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	mitochondrion | nucleus	4Fe-4S | DNA damage | DNA repair | Glycosidase | Hydrolase | Iron | Iron-sulfur | Lyase | Metal-binding | Mitochondrion | Nucleus | Reference proteome | Transit peptide		Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines
Haemaphysalis longicornis	44386	A0A9J6GQ35	ATP-dependent DNA helicase		944	Unreviewed	Nucleus, nucleoplasm	cell division | DNA replication | double-strand break repair via homologous recombination | negative regulation of macromolecule metabolic process | negative regulation of nucleobase-containing compound metabolic process	3'-5' DNA helicase activity | ATP binding | DNA binding | four-way junction helicase activity | hydrolase activity | metal ion binding	chromosome | cytoplasm | nucleoplasm	ATP-binding | Cell cycle | Cell division | DNA damage | DNA repair | DNA replication | DNA-binding | Helicase | Hydrolase | Isomerase | Metal-binding | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Zinc		
Haemaphysalis longicornis	44386	A0A9J6GPP9	Inositol-tetrakisphosphate 1-kinase		336	Unreviewed		inositol trisphosphate metabolic process	ATP binding | inositol-1,3,4-trisphosphate 5-kinase activity | inositol-1,3,4-trisphosphate 6-kinase activity | inositol-3,4,5,6-tetrakisphosphate 1-kinase activity | magnesium ion binding	cytoplasm	ATP-binding | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Reference proteome | Transferase		Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3
Haemaphysalis longicornis	44386	A0A9J6GPL8	DNA repair protein REV1		964	Unreviewed	Nucleus	DNA repair | error-free translesion synthesis | error-prone translesion synthesis	damaged DNA binding | deoxycytidyl transferase activity | DNA-directed DNA polymerase activity | metal ion binding	nucleus	DNA damage | DNA repair | DNA synthesis | DNA-binding | Magnesium | Metal-binding | Nucleotidyltransferase | Nucleus | Reference proteome | Transferase		Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents
Haemaphysalis longicornis	44386	A0A9J6GPE6	Exosome complex component 10 homolog		772	Unreviewed	Nucleus	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | histone mRNA catabolic process | nuclear polyadenylation-dependent antisense transcript catabolic process | nuclear polyadenylation-dependent CUT catabolic process | nuclear polyadenylation-dependent rRNA catabolic process | nuclear polyadenylation-dependent snoRNA catabolic process | nuclear polyadenylation-dependent snRNA catabolic process | poly(A)-dependent snoRNA 3'-end processing | TRAMP-dependent tRNA surveillance pathway	3'-5'-RNA exonuclease activity | nucleotide binding | single-stranded RNA binding	nuclear exosome (RNase complex) | nucleolus	Exonuclease | Exosome | Hydrolase | Nuclease | Nucleus | Reference proteome | rRNA processing		
Haemaphysalis longicornis	44386	A0A9J6GNT9	DNA (cytosine-5)-methyltransferase		1353	Unreviewed	Nucleus	DNA methylation-dependent constitutive heterochromatin formation | methylation | negative regulation of gene expression via chromosomal CpG island methylation	chromatin binding | DNA (cytosine-5-)-methyltransferase activity | DNA binding | zinc ion binding	nucleus	DNA-binding | Metal-binding | Methyltransferase | Nucleus | Reference proteome | Repeat | S-adenosyl-L-methionine | Transferase | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6GNM0	ADP-ribosylhydrolase ARH3		533	Unreviewed	Nucleus	protein transport	metal ion binding | poly(ADP-ribose) glycohydrolase activity	mitochondrion | nucleus	Hydrolase | Magnesium | Metal-binding | Nucleus | Protein transport | Reference proteome | Transport		
Haemaphysalis longicornis	44386	A0A9J6GNE3	MoaB/Mog domain-containing protein		462	Unreviewed		establishment of synaptic specificity at neuromuscular junction | gamma-aminobutyric acid receptor clustering | glycine receptor clustering | Mo-molybdopterin cofactor biosynthetic process | postsynaptic neurotransmitter receptor diffusion trapping	ATP binding | metal ion binding | molybdopterin adenylyltransferase activity | molybdopterin molybdotransferase activity	cytosol | dendrite | postsynaptic specialization membrane	ATP-binding | Magnesium | Metal-binding | Molybdenum | Molybdenum cofactor biosynthesis | Multifunctional enzyme | Nucleotide-binding | Reference proteome | Transferase		Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released
Haemaphysalis longicornis	44386	A0A9J6GN06	Delta-like protein		1036	Unreviewed	Membrane	germ-line stem cell population maintenance | gliogenesis | lateral inhibition | Notch signaling pathway | second mitotic wave involved in compound eye morphogenesis	calcium ion binding | glycosphingolipid binding | Notch binding | receptor ligand activity	apical cortex | cell surface | membrane	Calcium | Developmental protein | Disulfide bond | EGF-like domain | Glycoprotein | Membrane | Reference proteome | Repeat | Signal | Transmembrane | Transmembrane helix		Putative Notch ligand involved in the mediation of Notch signaling
Haemaphysalis longicornis	44386	A0A9J6GMN3	fructose-bisphosphatase		299	Unreviewed	Cytoplasm	fructose 1,6-bisphosphate metabolic process | fructose 6-phosphate metabolic process | fructose metabolic process | gluconeogenesis | sucrose biosynthetic process	fructose 1,6-bisphosphate 1-phosphatase activity | metal ion binding	cytosol	Carbohydrate metabolism | Cytoplasm | Hydrolase | Magnesium | Metal-binding | Phosphoprotein | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6GLW7	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase		332	Unreviewed	Golgi apparatus membrane	carbohydrate metabolic process | chondroitin sulfate proteoglycan biosynthetic process	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity | metal ion binding	Golgi membrane	Glycoprotein | Golgi apparatus | Manganese | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6GLS6	Serine/threonine-protein phosphatase		265	Unreviewed	Cell projection, pseudopodium	amoeboid sperm motility | egg-laying behavior | male meiosis chromosome segregation | regulation of pseudopodium assembly	metal ion binding | protein serine/threonine phosphatase activity	cytoplasm | nucleus | pseudopodium	Hydrolase | Manganese | Metal-binding | Protein phosphatase | Reference proteome		Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium
Haemaphysalis longicornis	44386	A0A9J6GLR2	N-alpha-acetyltransferase 20		103	Unreviewed			protein N-terminal-methionine acetyltransferase activity	NatB complex	Acyltransferase | Reference proteome | Transferase		Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration
Haemaphysalis longicornis	44386	A0A9J6GL60	protein acetyllysine N-acetyltransferase		437	Unreviewed	Nucleus		histone deacetylase activity, NAD-dependent | metal ion binding | NAD+ binding | p53 binding | transcription corepressor activity	nuclear inner membrane | nucleoplasm | rDNA heterochromatin	Metal-binding | NAD | Nucleus | Reference proteome | Transferase | Zinc		
Haemaphysalis longicornis	44386	A0A9J6GL45	O-phosphoseryl-tRNA(Sec) selenium transferase		476	Unreviewed	Cytoplasm	conversion of seryl-tRNAsec to selenocys-tRNAsec | selenocysteine incorporation	O-phosphoseryl-tRNA(Sec) selenium transferase activity | tRNA binding	cytoplasm	Cytoplasm | Protein biosynthesis | Pyridoxal phosphate | Reference proteome | RNA-binding | Selenium | Transferase | tRNA-binding		Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis
Haemaphysalis longicornis	44386	A0A9J6GKZ7	cysteine--tRNA ligase		547	Unreviewed		cysteinyl-tRNA aminoacylation	ATP binding | cysteine-tRNA ligase activity | metal ion binding	cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Metal-binding | Nucleotide-binding | Protein biosynthesis | Reference proteome | Zinc		In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants
Haemaphysalis longicornis	44386	A0A9J6GXU3	Ribosome biogenesis protein NSA2 homolog		386	Unreviewed	Cytoplasm | Nucleus, nucleolus	rRNA processing | translation	structural constituent of ribosome	cytoplasm | nucleolus | ribonucleoprotein complex | ribosome	Cytoplasm | Isopeptide bond | Nucleus | Reference proteome | Ribonucleoprotein | Ribosomal protein | Ribosome biogenesis | rRNA processing | Zinc		Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles
Haemaphysalis longicornis	44386	A0A9J6GY15	E1 ubiquitin-activating enzyme		1047	Unreviewed		protein sumoylation	ATP binding | SUMO activating enzyme activity | ubiquitin activating enzyme activity	cytoplasm | SUMO activating enzyme complex	ATP-binding | Ligase | Nucleotide-binding | Reference proteome | Ubl conjugation pathway		
Haemaphysalis longicornis	44386	A0A9J6H3X2	RuvB-like helicase		452	Unreviewed	Nucleus	chromatin organization | DNA recombination | DNA repair | positive regulation of gene expression | regulation of canonical Wnt signaling pathway | regulation of cell population proliferation	ATP binding | DNA helicase activity | hydrolase activity | transcription coregulator activity	histone acetyltransferase complex | nucleus	ATP-binding | Chromatin regulator | DNA damage | DNA recombination | DNA repair | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Reference proteome | Transcription | Transcription regulation		Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair
Haemaphysalis longicornis	44386	A0A9J6GYS3	Adenylosuccinate synthetase		159	Unreviewed	Cytoplasm	'de novo' AMP biosynthetic process | IMP metabolic process	adenylosuccinate synthase activity | GTP binding | magnesium ion binding	cytoplasm	Cytoplasm | GTP-binding | Ligase | Magnesium | Metal-binding | Nucleotide-binding | Purine biosynthesis | Reference proteome		Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP
Haemaphysalis longicornis	44386	A0A9J6H3S3	CTP synthase		669	Unreviewed		'de novo' CTP biosynthetic process | pyrimidine nucleobase biosynthetic process	ATP binding | CTP synthase activity | identical protein binding | metal ion binding	cytoophidium | cytoplasm	ATP-binding | Glutamine amidotransferase | Ligase | Magnesium | Metal-binding | Nucleotide-binding | Pyrimidine biosynthesis | Reference proteome		Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen
Haemaphysalis longicornis	44386	A0A9J6H3Q3	non-specific serine/threonine protein kinase		869	Unreviewed			ATP binding | protein serine/threonine kinase activity | RNA binding | translation initiation factor activity		ATP-binding | Initiation factor | Kinase | Nucleotide-binding | Phosphoprotein | Protein biosynthesis | Reference proteome | Repeat | Serine/threonine-protein kinase | Transferase		Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1
Haemaphysalis longicornis	44386	A0A9J6H3Q0	Dual serine/threonine and tyrosine protein kinase		900	Unreviewed	Cytoplasm	cellular response to fibroblast growth factor stimulus | negative regulation of apoptotic process | positive regulation of ERK1 and ERK2 cascade | positive regulation of fibroblast growth factor receptor signaling pathway	ATP binding | protein serine/threonine kinase activity | protein serine/threonine/tyrosine kinase activity | protein tyrosine kinase activity	cytoplasm	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Reference proteome | Serine/threonine-protein kinase | Transferase | Tyrosine-protein kinase		
Haemaphysalis longicornis	44386	A0A9J6H3K0	Sphingomyelin phosphodiesterase		606	Unreviewed	Secreted	ceramide biosynthetic process | sphingomyelin catabolic process	acid sphingomyelin phosphodiesterase activity | hydrolase activity, acting on glycosyl bonds | metal ion binding	extracellular space | lysosome | membrane	Disulfide bond | Glycoprotein | Glycosidase | Hydrolase | Metal-binding | Reference proteome | Secreted | Signal | Zinc		Converts sphingomyelin to ceramide
Haemaphysalis longicornis	44386	A0A9J6H353	Aurora kinase		350	Unreviewed	Midbody	chromatin organization | chromosome condensation | cytokinetic process | mitotic sister chromatid segregation	ATP binding | protein serine/threonine kinase activity	midbody	ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6H346	Frizzled-10		608	Unreviewed	Cell membrane	canonical Wnt signaling pathway | non-canonical Wnt signaling pathway	G protein-coupled receptor activity | Wnt-protein binding	extracellular space | plasma membrane	Cell membrane | Developmental protein | Disulfide bond | G-protein coupled receptor | Glycoprotein | Membrane | Receptor | Reference proteome | Signal | Transducer | Transmembrane | Transmembrane helix | Wnt signaling pathway		
Haemaphysalis longicornis	44386	A0A9J6H339	Guanine nucleotide-binding protein G(I) subunit alpha		369	Unreviewed		adenylate cyclase-modulating G protein-coupled receptor signaling pathway | asymmetric cell division | axon ensheathment in central nervous system | calcium-mediated signaling | cortical actin cytoskeleton organization | establishment of glial blood-brain barrier | septate junction assembly | ventral cord development	G protein-coupled receptor binding | G-protein beta/gamma-subunit complex binding | GTP binding | GTPase activity | metal ion binding	cytoplasm | heterotrimeric G-protein complex	GTP-binding | Lipoprotein | Magnesium | Metal-binding | Myristate | Nucleotide-binding | Palmitate | Reference proteome | Transducer		
Haemaphysalis longicornis	44386	A0A9J6H335	Cyclin-dependent kinase 8		470	Unreviewed	Nucleus		ATP binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	nucleus	ATP-binding | Kinase | Nucleotide-binding | Nucleus | Reference proteome | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6H301	Ubiquinone biosynthesis O-methyltransferase, mitochondrial		279	Unreviewed	Mitochondrion inner membrane	methylation	3-demethylubiquinol 3-O-methyltransferase activity | metal ion binding | polyprenyldihydroxybenzoate methyltransferase activity	extrinsic component of mitochondrial inner membrane	Magnesium | Membrane | Metal-binding | Methyltransferase | Mitochondrion | Mitochondrion inner membrane | Reference proteome | S-adenosyl-L-methionine | Transferase | Ubiquinone biosynthesis		O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol
Haemaphysalis longicornis	44386	A0A9J6H2Q7	Presenilin		478	Unreviewed	Endomembrane system | Endoplasmic reticulum membrane | Golgi apparatus membrane	amyloid-beta formation | calcium ion homeostasis | membrane protein ectodomain proteolysis | Notch signaling pathway | protein processing	aspartic endopeptidase activity, intramembrane cleaving	endoplasmic reticulum membrane | gamma-secretase complex | Golgi membrane	Endoplasmic reticulum | Golgi apparatus | Hydrolase | Membrane | Notch signaling pathway | Protease | Reference proteome | Transmembrane | Transmembrane helix		Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors
Haemaphysalis longicornis	44386	A0A9J6H2N8	Forkhead box protein O		693	Unreviewed	Cytoplasm | Nucleus	cellular response to oxidative stress | determination of adult lifespan | insulin receptor signaling pathway | negative regulation of multicellular organism growth | positive regulation of catabolic process | positive regulation of defense response | positive regulation of immune response | regulation of lipid storage | response to starvation	DNA-binding transcription activator activity, RNA polymerase II-specific | RNA polymerase II cis-regulatory region sequence-specific DNA binding | zinc ion binding	cytoplasm | nucleus	Activator | Cell cycle | Cytoplasm | Developmental protein | DNA-binding | Growth regulation | Metal-binding | Nucleus | Phosphoprotein | Reference proteome | Transcription | Transcription regulation | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6H2J6	Unconventional myosin-VI		1226	Unreviewed	Cytoplasm	actin filament organization | actin filament-based movement | animal organ development | system development | tissue development	actin filament binding | ATP binding | calmodulin binding | microfilament motor activity	endocytic vesicle | myosin complex | plasma membrane	Actin-binding | ATP-binding | Calmodulin-binding | Coiled coil | Cytoplasm | Motor protein | Myosin | Nucleotide-binding | Phosphoprotein | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6H2D5	E3 ubiquitin-protein ligase listerin		1735	Unreviewed		rescue of stalled ribosome | ribosome-associated ubiquitin-dependent protein catabolic process	ribosomal large subunit binding | ubiquitin protein ligase activity | zinc ion binding	cytosol | RQC complex	Metal-binding | Reference proteome | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation
Haemaphysalis longicornis	44386	A0A9J6GKC7	Dicer-1		1491	Unreviewed		anatomical structure morphogenesis | apoptotic DNA fragmentation | developmental process involved in reproduction | pre-miRNA processing | response to stress | siRNA processing | system development	ATP binding | deoxyribonuclease I activity | helicase activity | metal ion binding | ribonuclease III activity | RNA binding	cytosol | nucleus | RISC-loading complex	ATP-binding | Endonuclease | Helicase | Hydrolase | Magnesium | Manganese | Metal-binding | Nuclease | Nucleotide-binding | Reference proteome | Repeat | RNA-binding | RNA-mediated gene silencing		
Haemaphysalis longicornis	44386	A0A9J6H2C6	Phosphotransferase		400	Unreviewed		glucose metabolic process | glycolytic process | intracellular glucose homeostasis	ATP binding | D-glucose binding | fructokinase activity | glucokinase activity	cytosol | mitochondrion	ATP-binding | Glycolysis | Kinase | Nucleotide-binding | Reference proteome | Transferase		
Haemaphysalis longicornis	44386	A0A9J6H2A0	Protein detached		964	Unreviewed	Cell membrane, sarcolemma | Cytoplasm, cytoskeleton	establishment of cell polarity | maintenance of presynaptic active zone structure | muscle cell cellular homeostasis | neuromuscular synaptic transmission | regulation of neurotransmitter secretion | regulation of short-term neuronal synaptic plasticity	actin binding | WW domain binding | zinc ion binding	cytoplasm | cytoskeleton | dystrophin-associated glycoprotein complex | neuromuscular junction | sarcolemma	Actin-binding | Calcium | Cell membrane | Coiled coil | Cytoplasm | Cytoskeleton | Membrane | Metal-binding | Reference proteome | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6H272	Uncharacterized protein		165	Unreviewed	Endomembrane system			endomembrane system | membrane	Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6H1U9	Elongation of very long chain fatty acids protein		109	Unreviewed	Membrane	fatty acid elongation, monounsaturated fatty acid | fatty acid elongation, polyunsaturated fatty acid | fatty acid elongation, saturated fatty acid | sphingolipid biosynthetic process | very long-chain fatty acid biosynthetic process	fatty acid elongase activity	endoplasmic reticulum membrane	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Membrane | Reference proteome | Transferase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6H1K4	DNA polymerase		335	Unreviewed	Cytoplasm | Nucleus	base-excision repair | double-strand break repair via nonhomologous end joining	class I DNA-(apurinic or apyrimidinic site) endonuclease activity | DNA binding | DNA-directed DNA polymerase activity | metal ion binding	cytoplasm | nucleus	Cytoplasm | DNA damage | DNA repair | DNA replication | DNA synthesis | DNA-binding | DNA-directed DNA polymerase | Lyase | Magnesium | Metal-binding | Methylation | Nucleotidyltransferase | Nucleus | Reference proteome | Sodium | Transferase | Ubl conjugation		DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity
Haemaphysalis longicornis	44386	A0A9J6H168	Trifunctional purine biosynthetic protein adenosine-3		1266	Unreviewed		'de novo' IMP biosynthetic process | adenine biosynthetic process	ATP binding | metal ion binding | phosphoribosylamine-glycine ligase activity | phosphoribosylformylglycinamidine cyclo-ligase activity | phosphoribosylglycinamide formyltransferase activity	cytosol	ATP-binding | Ligase | Manganese | Metal-binding | Multifunctional enzyme | Nucleotide-binding | Purine biosynthesis | Reference proteome | Transferase		
Haemaphysalis longicornis	44386	A0A9J6H0Z5	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial		452	Unreviewed	Mitochondrion	succinyl-CoA metabolic process | tricarboxylic acid cycle	ATP binding | GTP binding | magnesium ion binding | succinate-CoA ligase (ADP-forming) activity | succinate-CoA ligase (GDP-forming) activity	mitochondrion | succinate-CoA ligase complex	GTP-binding | Ligase | Magnesium | Metal-binding | Mitochondrion | Nucleotide-binding | Reference proteome | Tricarboxylic acid cycle		GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
Haemaphysalis longicornis	44386	A0A9J6H0M2	Myosin class i heavy chain		1551	Unreviewed		animal organ morphogenesis | signal transduction | system development | tissue development	actin binding | ATP binding | cytoskeletal motor activity | GTPase activator activity	cell periphery | cytoplasm | myosin complex	Actin-binding | ATP-binding | Coiled coil | GTPase activation | Motor protein | Myosin | Nucleotide-binding | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6H0K8	DNA repair protein RAD51 homolog		316	Unreviewed	Nucleus	chromosome organization involved in meiotic cell cycle | DNA recombinase assembly | DNA strand invasion | mitotic recombination | mitotic recombination-dependent replication fork processing | reciprocal meiotic recombination	ATP binding | ATP-dependent DNA damage sensor activity | DNA strand exchange activity | double-stranded DNA binding | single-stranded DNA binding	condensed nuclear chromosome	ATP-binding | DNA damage | DNA recombination | DNA repair | DNA-binding | Nucleotide-binding | Nucleus | Reference proteome		Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA
Haemaphysalis longicornis	44386	A0A9J6H008	Chromatin-remodeling ATPase INO80		1751	Unreviewed	Nucleus	chromatin remodeling | DNA repair	ATP binding | ATP hydrolysis activity | DNA binding | histone binding	Ino80 complex	ATP-binding | DNA damage | DNA repair | DNA-binding | Hydrolase | Nucleotide-binding | Nucleus | Reference proteome		ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair
Haemaphysalis longicornis	44386	A0A9J6GZP8	Ribokinase		317	Unreviewed	Cytoplasm | Nucleus	D-ribose catabolic process	ATP binding | metal ion binding | ribokinase activity	cytosol | nucleus	ATP-binding | Carbohydrate metabolism | Cytoplasm | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Nucleus | Potassium | Reference proteome | Transferase		Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Haemaphysalis longicornis	44386	A0A9J6GZJ3	DNA 3'-5' helicase		1460	Unreviewed	Nucleus	DNA replication | double-strand break repair via homologous recombination | reciprocal meiotic recombination	3'-5' DNA helicase activity | ATP binding | DNA binding | four-way junction helicase activity | hydrolase activity	chromosome | cytoplasm | nucleus	ATP-binding | DNA damage | DNA repair | DNA-binding | Helicase | Hydrolase | Isomerase | Nucleotide-binding | Nucleus | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6GZ37	alpha-1,2-Mannosidase		629	Unreviewed	Endomembrane system	carbohydrate metabolic process	calcium ion binding | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum | Golgi membrane	Calcium | Disulfide bond | Glycosidase | Hydrolase | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transmembrane | Transmembrane helix		Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)
Haemaphysalis longicornis	44386	A0A9J6GYZ0	Poly [ADP-ribose] polymerase		373	Unreviewed	Chromosome | Cytoplasm, cytosol | Nucleus, nucleolus	double-strand break repair | innate immune response | protein poly-ADP-ribosylation	DNA binding | NAD+ poly-ADP-ribosyltransferase activity | NAD+-protein mono-ADP-ribosyltransferase activity | nucleotidyltransferase activity | zinc ion binding	chromosome | cytosol | nucleolus	ADP-ribosylation | Allosteric enzyme | Chromosome | Cytoplasm | DNA-binding | Glycosyltransferase | Immunity | Innate immunity | Isopeptide bond | Metal-binding | NAD | Nucleotidyltransferase | Nucleus | Reference proteome | Repeat | Transcription | Transcription regulation | Transferase | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6H2A5	Queuine tRNA-ribosyltransferase accessory subunit 2		908	Unreviewed	Cytoplasm | Nucleus	cell division | mitotic chromosome condensation | tRNA modification	ATP binding | metal ion binding | tRNA-guanosine(34) queuine transglycosylase activity	condensin complex | cytoplasm | nucleus	ATP-binding | Cell cycle | Cell division | Coiled coil | Cytoplasm | DNA condensation | Metal-binding | Mitosis | Nucleotide-binding | Nucleus | Reference proteome | tRNA processing | Zinc		Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
Haemaphysalis longicornis	44386	A0A9J6GIX9	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase		477	Unreviewed	Golgi apparatus membrane	oligosaccharide biosynthetic process | protein N-linked glycosylation	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity | metal ion binding	Golgi membrane | Golgi stack	Disulfide bond | Glycoprotein | Glycosyltransferase | Golgi apparatus | Manganese | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6G7V0	DNA-directed RNA polymerase subunit		985	Unreviewed	Chromosome | Cytoplasm | Nucleus	DNA-templated transcription	DNA binding | DNA-directed RNA polymerase activity | hydrolase activity | metal ion binding	chromosome | cytoplasm | RNA polymerase II, core complex	Acetylation | Chromosome | Cytoplasm | DNA-directed RNA polymerase | Hydrolase | Magnesium | Metal-binding | Methylation | Nucleotidyltransferase | Nucleus | Reference proteome | Transcription | Transferase | Zinc		DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Haemaphysalis longicornis	44386	A0A9J6GI91	DNA-directed RNA polymerase subunit beta		1151	Unreviewed	Cytoplasm, cytosol | Nucleus	defense response to virus | innate immune response | transcription by RNA polymerase III	DNA binding | DNA-directed RNA polymerase activity | metal ion binding | ribonucleoside binding	cytosol | DNA-directed RNA polymerase complex | nucleus	Antiviral defense | Cytoplasm | DNA-directed RNA polymerase | Immunity | Innate immunity | Magnesium | Metal-binding | Nucleotidyltransferase | Nucleus | Reference proteome | Transcription | Transferase | Zinc		DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Haemaphysalis longicornis	44386	A0A9J6G732	Ecdysone receptor		420	Unreviewed	Nucleus	cell differentiation | ecdysone receptor signaling pathway | negative regulation of transcription by RNA polymerase II | positive regulation of transcription by RNA polymerase II	ecdysone binding | nuclear receptor activity | RNA polymerase II cis-regulatory region sequence-specific DNA binding | zinc ion binding	RNA polymerase II transcription regulator complex	DNA-binding | Metal-binding | Nucleus | Receptor | Reference proteome | Transcription | Transcription regulation | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6G702	(3R)-3-hydroxyacyl-CoA dehydrogenase		254	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6G6X7	Serine/threonine-protein kinase RIO2		523	Unreviewed	Cytoplasm	maturation of SSU-rRNA	ATP binding | metal ion binding | protein serine/threonine kinase activity	cytosol | nucleus | preribosome, small subunit precursor	ATP-binding | Cytoplasm | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Reference proteome | Ribosome biogenesis | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6G6Q6	Sialin		527	Unreviewed	Basolateral cell membrane | Cytoplasmic vesicle, secretory vesicle membrane | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane | Lysosome membrane	carboxylic acid transport | monoatomic anion transport	symporter activity	basolateral plasma membrane | lysosomal membrane | synaptic vesicle membrane	Cell membrane | Cytoplasmic vesicle | Glycoprotein | Lysosome | Membrane | Reference proteome | Symport | Synapse | Transmembrane | Transmembrane helix | Transport		Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties
Haemaphysalis longicornis	44386	A0A9J6G6Q2	VLRF1 domain-containing protein		657	Unreviewed	Cytoplasm | Target cell membrane	ERAD pathway | exocytosis	endonuclease activity | hydrolase activity	cytoplasm | host cell presynaptic membrane | other organism cell membrane	ANK repeat | Coiled coil | Cytoplasm | Endonuclease | Exocytosis | Hydrolase | Membrane | Neurotoxin | Nuclease | Presynaptic neurotoxin | Reference proteome | Repeat | Target cell membrane | Target membrane | Toxin		
Haemaphysalis longicornis	44386	A0A9J6G6K2	Agenet-like domain-containing protein		569	Unreviewed	Cell projection, neuron projection | Cytoplasm, Stress granule | Perikaryon | Synapse	animal organ development | mRNA transport | nervous system development | positive regulation of long-term neuronal synaptic plasticity | positive regulation of translation | regulation of mRNA stability | regulation of translation at presynapse, modulating synaptic transmission	mRNA 3'-UTR binding | translation regulator activity	cytoplasmic stress granule | neuron projection | nucleus | perikaryon | presynapse | ribonucleoprotein complex	Cell projection | Cytoplasm | Neurogenesis | Reference proteome | Repeat | Repressor | Ribonucleoprotein | RNA-binding | Synapse | Translation regulation		
Haemaphysalis longicornis	44386	A0A9J6G6B0	Phospholipid-transporting ATPase		582	Unreviewed	Membrane	Golgi organization | phospholipid translocation	ATP binding | ATP hydrolysis activity | ATPase-coupled intramembrane lipid transporter activity | magnesium ion binding	plasma membrane | trans-Golgi network	ATP-binding | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Reference proteome | Translocase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6G697	(3R)-3-hydroxyacyl-CoA dehydrogenase		253	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6G649	Sugar phosphate phosphatase		472	Unreviewed		DNA damage response | methylation	metal ion binding | phosphatase activity | protein carboxyl O-methyltransferase activity	nucleus	Hydrolase | Manganese | Metal-binding | Methyltransferase | Nickel | Reference proteome | S-adenosyl-L-methionine | Transferase		Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response
Haemaphysalis longicornis	44386	A0A9J6G637	Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial		366	Unreviewed	Mitochondrion	glutamyl-tRNA aminoacylation	ATP binding | glutamate-tRNA ligase activity | glutamate-tRNA(Gln) ligase activity | zinc ion binding	mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6G5V3	Amine oxidase		102	Unreviewed	Mitochondrion outer membrane		flavin adenine dinucleotide binding | monoamine oxidase activity | primary methylamine oxidase activity	mitochondrial outer membrane	FAD | Flavoprotein | Membrane | Oxidoreductase | Reference proteome | Transmembrane | Transmembrane helix		Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine
Haemaphysalis longicornis	44386	A0A9J6G5U9	Phospholipid-transporting ATPase		660	Unreviewed	Membrane	Golgi organization | phospholipid translocation	ATP binding | ATPase-coupled intramembrane lipid transporter activity | magnesium ion binding	plasma membrane | trans-Golgi network	ATP-binding | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Reference proteome | Translocase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6G5K4	4-hydroxy-2-oxoglutarate aldolase, mitochondrial		312	Unreviewed		glyoxylate catabolic process	(R,S)-4-hydroxy-2-oxoglutarate aldolase activity | 4-hydroxy-tetrahydrodipicolinate synthase activity	mitochondrion	Lyase | Reference proteome | Schiff base		Catalyzes the final step in the metabolic pathway of hydroxyproline
Haemaphysalis longicornis	44386	A0A9J6G5H8	Phospholipid-transporting ATPase		1040	Unreviewed	Membrane	phospholipid translocation	ATP binding | ATP hydrolysis activity | ATPase-coupled intramembrane lipid transporter activity | magnesium ion binding	plasma membrane | trans-Golgi network	ATP-binding | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Reference proteome | Translocase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6G5H4	Peptidylglycine alpha-amidating monooxygenase		745	Unreviewed		peptide metabolic process	copper ion binding | peptidylamidoglycolate lyase activity | peptidylglycine monooxygenase activity	extracellular region | membrane	Calcium | Copper | Disulfide bond | Glycoprotein | Lyase | Membrane | Metal-binding | Multifunctional enzyme | Reference proteome | Repeat | Signal | Transmembrane | Transmembrane helix | Zinc		
Haemaphysalis longicornis	44386	A0A9J6G5F2	ATP-dependent DNA helicase		662	Unreviewed	Nucleus	double-strand break repair via homologous recombination	3'-5' DNA helicase activity | ATP binding | DNA binding | four-way junction helicase activity | hydrolase activity | metal ion binding	chromosome | cytoplasm | nucleus	ATP-binding | Coiled coil | DNA-binding | Helicase | Hydrolase | Isomerase | Metal-binding | Nucleotide-binding | Nucleus | Reference proteome | Zinc		
Haemaphysalis longicornis	44386	A0A9J6G5B3	Phosphomannomutase		257	Unreviewed	Cytoplasm	GDP-mannose biosynthetic process | mannose metabolic process | protein N-linked glycosylation	metal ion binding | phosphomannomutase activity	cytosol	Cytoplasm | Isomerase | Magnesium | Metal-binding | Reference proteome		Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions
Haemaphysalis longicornis	44386	A0A9J6G5B0	(3R)-3-hydroxyacyl-CoA dehydrogenase		253	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6G564	ornithine decarboxylase		458	Unreviewed		putrescine biosynthetic process from arginine, via ornithine	ornithine decarboxylase activity	cytoplasm	Lyase | Polyamine biosynthesis | Pyridoxal phosphate | Reference proteome		Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis
Haemaphysalis longicornis	44386	A0A9J6G4Y1	Polypeptide N-acetylgalactosaminyltransferase		676	Unreviewed	Golgi apparatus membrane	protein O-linked glycosylation	carbohydrate binding | metal ion binding | polypeptide N-acetylgalactosaminyltransferase activity	Golgi membrane	Disulfide bond | Glycoprotein | Glycosyltransferase | Golgi apparatus | Lectin | Manganese | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6G4S2	Glycine--tRNA ligase		725	Unreviewed	Cell projection, axon | Cytoplasm	mitochondrial glycyl-tRNA aminoacylation	ATP binding | glycine-tRNA ligase activity | transferase activity	axon | mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Cell projection | Coiled coil | Cytoplasm | Ligase | Nucleotide-binding | Protein biosynthesis | Reference proteome | Transferase		
Haemaphysalis longicornis	44386	A0A9J6G4P8	(3R)-3-hydroxyacyl-CoA dehydrogenase		258	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6G4K2	Nuclear receptor domain-containing protein		264	Unreviewed	Nucleus	cardioblast cell fate determination | fat body development | neuron-neuron synaptic transmission | phototaxis | R1/R6 cell fate commitment | R3/R4 cell fate commitment	DNA-binding transcription factor activity | protein heterodimerization activity | sequence-specific DNA binding | zinc ion binding	nucleus | synapse	DNA-binding | Metal-binding | Nucleus | Receptor | Reference proteome | Transcription | Transcription regulation | Zinc | Zinc-finger		Receptor that is required in photoreceptors R1, R3, R4 and R6 during eye development; generation of the ganglion mother cell-2 (GMC-2) fate in the nb7-3 lineage, coinciding with the transition in the expression of HB to KR in the neuroblasts (NBs)
Haemaphysalis longicornis	44386	A0A9J6G4F1	(3R)-3-hydroxyacyl-CoA dehydrogenase		307	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6G4D2	glycerophosphocholine cholinephosphodiesterase		389	Unreviewed	Cell membrane		hydrolase activity		Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Haemaphysalis longicornis	44386	A0A9J6G456	Protein kinase domain-containing protein		452	Unreviewed	Cell membrane | Cytoplasm, myofibril, sarcomere | Target cell membrane	anatomical structure morphogenesis | cell-matrix adhesion | exocytosis | integrin-mediated signaling pathway | substrate adhesion-dependent cell spreading	ATP binding | protein serine/threonine kinase activity	focal adhesion | host cell presynaptic membrane | other organism cell membrane | plasma membrane | sarcomere | stress fiber	ANK repeat | Cell membrane | Cytoplasm | Exocytosis | Membrane | Neurotoxin | Presynaptic neurotoxin | Reference proteome | Repeat | Target cell membrane | Target membrane | Toxin		
Haemaphysalis longicornis	44386	A0A9J6H3X3	Vitamin K-dependent protein C		258	Unreviewed	Endoplasmic reticulum | Golgi apparatus | Secreted	hemostasis | proteolysis	serine-type endopeptidase activity	endoplasmic reticulum | extracellular region | Golgi apparatus	Disulfide bond | Endoplasmic reticulum | Glycoprotein | Golgi apparatus | Hemostasis | Hydrolase | Protease | Reference proteome | Secreted | Serine protease		Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function
Haemaphysalis longicornis	44386	A0A9J6G755	(3R)-3-hydroxyacyl-CoA dehydrogenase		256	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6G7F9	Phosphatidylinositol 3-kinase catalytic subunit type 3		1084	Unreviewed		autophagosome assembly | endocytosis | phosphatidylinositol-mediated signaling	1-phosphatidylinositol-3-kinase activity | ATP binding | phosphatidylinositol binding	endosome | peroxisome | phagophore assembly site | phosphatidylinositol 3-kinase complex, class III, type I | phosphatidylinositol 3-kinase complex, class III, type II	ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Transferase		
Haemaphysalis longicornis	44386	A0A9J6G7G6	Vitamin K-dependent protein C		219	Unreviewed	Endoplasmic reticulum | Golgi apparatus | Secreted	hemostasis | proteolysis	serine-type endopeptidase activity	endoplasmic reticulum | extracellular space | Golgi apparatus	Disulfide bond | Endoplasmic reticulum | Glycoprotein | Golgi apparatus | Hemostasis | Hydrolase | Protease | Reference proteome | Secreted | Serine protease		Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function
Haemaphysalis longicornis	44386	A0A9J6G9L6	Sialin		490	Unreviewed	Basolateral cell membrane | Cytoplasmic vesicle, secretory vesicle membrane | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane | Lysosome membrane	carboxylic acid transport | monoatomic anion transport	symporter activity	basolateral plasma membrane | lysosomal membrane | synaptic vesicle membrane	Cell membrane | Cytoplasmic vesicle | Glycoprotein | Lysosome | Membrane | Reference proteome | Signal | Symport | Synapse | Transmembrane | Transmembrane helix | Transport		Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties
Haemaphysalis longicornis	44386	A0A9J6GHF3	Methyltransferase HEMK2		183	Unreviewed	Nucleus	methylation	nucleic acid binding | protein-glutamine N-methyltransferase activity	eRF1 methyltransferase complex | nucleus	Methyltransferase | Nucleus | Reference proteome | S-adenosyl-L-methionine | Transferase		Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT
Haemaphysalis longicornis	44386	A0A9J6GHE7	Phosphatidylinositol-4-phosphate 3-kinase		1571	Unreviewed		cell migration | phosphatidylinositol 3-kinase/protein kinase B signal transduction | phosphatidylinositol-mediated signaling	1-phosphatidylinositol-3-kinase activity | 1-phosphatidylinositol-4-phosphate 3-kinase activity | ATP binding | phosphatidylinositol binding	cytoplasm | phosphatidylinositol 3-kinase complex | plasma membrane	ATP-binding | Kinase | Lipid metabolism | Nucleotide-binding | Reference proteome | Transferase		
Haemaphysalis longicornis	44386	A0A9J6GGI3	t-SNARE coiled-coil homology domain-containing protein		227	Unreviewed	Endomembrane system	Golgi to vacuole transport | intra-Golgi vesicle-mediated transport | intracellular protein transport | macroautophagy | regulation of protein localization to plasma membrane | retrograde transport, endosome to Golgi | vesicle fusion with Golgi apparatus	SNAP receptor activity | SNARE binding	cytosol | endoplasmic reticulum membrane | ER to Golgi transport vesicle membrane | Golgi apparatus | late endosome membrane | SNARE complex	Coiled coil | Membrane | Protein transport | Reference proteome | Transmembrane | Transmembrane helix | Transport		
Haemaphysalis longicornis	44386	A0A9J6GGD9	Beta-1,4-glucuronyltransferase 1		423	Unreviewed	Golgi apparatus membrane	protein O-linked glycosylation via mannose	glucuronosyltransferase activity | metal ion binding	Golgi membrane	Glycoprotein | Glycosyltransferase | Golgi apparatus | Manganese | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6GG84	Phosphoglycerate kinase		450	Unreviewed		gluconeogenesis | glycolytic process	ADP binding | ATP binding | metal ion binding | phosphoglycerate kinase activity	cytosol	ATP-binding | Glycolysis | Kinase | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Reference proteome | Transferase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6GG44	Eukaryotic translation initiation factor 4 gamma 2		1462	Unreviewed	Membrane	potassium ion transport | regulation of translation | sodium ion transport	mRNA binding | translation initiation factor activity	eukaryotic translation initiation factor 4F complex | sodium:potassium-exchanging ATPase complex	Acetylation | Initiation factor | Isopeptide bond | Membrane | Methylation | Protein biosynthesis | Reference proteome | Repressor | Signal-anchor | Translation regulation | Transmembrane | Transmembrane helix | Ubl conjugation		Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases
Haemaphysalis longicornis	44386	A0A9J6GFD4	Adenylate kinase isoenzyme 6 homolog		176	Unreviewed	Cytoplasm | Nucleus	ribosomal small subunit biogenesis | rRNA processing	AMP kinase activity | ATP binding | ATP hydrolysis activity	cytoplasm | nucleus	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Nucleus | Reference proteome | Ribosome biogenesis | rRNA processing | Transferase		Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis
Haemaphysalis longicornis	44386	A0A9J6GFB3	Adenylate kinase		250	Unreviewed	Cytoplasm, cytosol | Mitochondrion intermembrane space	ADP biosynthetic process | AMP metabolic process | ATP metabolic process	AMP kinase activity | ATP binding	cytosol | mitochondrial intermembrane space	ATP-binding | Cytoplasm | Kinase | Mitochondrion | Nucleotide-binding | Reference proteome | Transferase		Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways
Haemaphysalis longicornis	44386	A0A9J6GF83	Glucosamine-6-phosphate isomerase		290	Unreviewed	Cytoplasm	carbohydrate metabolic process | glucosamine catabolic process | N-acetylglucosamine catabolic process | N-acetylneuraminate catabolic process	glucosamine-6-phosphate deaminase activity | identical protein binding	cytoplasm	Carbohydrate metabolism | Cytoplasm | Hydrolase | Reference proteome		Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway
Haemaphysalis longicornis	44386	A0A9J6GEW5	DNA replication licensing factor MCM3		610	Unreviewed	Nucleus	DNA strand elongation involved in DNA replication | double-strand break repair via break-induced replication | mitotic DNA replication initiation	ATP binding | hydrolase activity | single-stranded DNA binding | single-stranded DNA helicase activity	MCM complex | nucleus	ATP-binding | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Reference proteome		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Haemaphysalis longicornis	44386	A0A9J6GEV2	ADP/ATP translocase		206	Unreviewed	Membrane | Mitochondrion inner membrane	mitochondrial ADP transmembrane transport | mitochondrial ATP transmembrane transport | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ATP:ADP antiporter activity	mitochondrial inner membrane	Antiport | Membrane | Mitochondrion | Mitochondrion inner membrane | Reference proteome | Repeat | Transmembrane | Transmembrane helix | Transport		ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane
Haemaphysalis longicornis	44386	A0A9J6GEK0	Spartin		462	Unreviewed	Cytoplasm | Lipid droplet | Midbody	cell division | lipid catabolic process | lipid transport | lipophagy | negative regulation of BMP signaling pathway	lipid binding	cytoplasm | lipid droplet | midbody | plasma membrane	Acetylation | Cytoplasm | Isopeptide bond | Lipid degradation | Lipid droplet | Lipid metabolism | Lipid transport | Lipid-binding | Phosphoprotein | Reference proteome | Transport | Ubl conjugation		Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons. Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy. Lipid transfer protein required for lipid droplet degradation, including by lipophagy. Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown. May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis
Haemaphysalis longicornis	44386	A0A9J6GE28	Death domain-associated protein 6		796	Unreviewed	Chromosome, centromere | Cytoplasm | Nucleus, PML body | Nucleus, nucleolus | Nucleus, nucleoplasm	apoptotic process | chromatin organization	histone binding | nuclear androgen receptor binding | transcription coactivator activity | transcription corepressor activity	chromosome, centromeric region | cytoplasm | nucleolus | PML body	Apoptosis | Centromere | Chaperone | Chromatin regulator | Chromosome | Coiled coil | Cytoplasm | Isopeptide bond | Nucleus | Phosphoprotein | Reference proteome | Repressor | Transcription | Transcription regulation | Ubl conjugation		
Haemaphysalis longicornis	44386	A0A9J6GIP0	U5 small nuclear ribonucleoprotein 200 kDa helicase		2073	Unreviewed	Nucleus	mRNA splicing, via spliceosome | resolution of meiotic recombination intermediates	ATP binding | DNA helicase activity | hydrolase activity | nucleic acid binding | RNA helicase activity	small nuclear ribonucleoprotein complex | spliceosomal complex	ATP-binding | Helicase | Hydrolase | mRNA processing | mRNA splicing | Nucleotide-binding | Nucleus | Reference proteome | Repeat | Spliceosome		Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing
Haemaphysalis longicornis	44386	A0A9J6GDK3	Flavin-containing monooxygenase		554	Unreviewed	Endoplasmic reticulum membrane		flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Membrane | Monooxygenase | NADP | Oxidoreductase | Reference proteome | Transmembrane | Transmembrane helix		Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine
Haemaphysalis longicornis	44386	A0A9J6GD53	Ribose-phosphate pyrophosphokinase 2		470	Unreviewed		5-phosphoribose 1-diphosphate biosynthetic process | purine nucleotide biosynthetic process | ribonucleoside monophosphate biosynthetic process	ATP binding | kinase activity | magnesium ion binding | ribose phosphate diphosphokinase activity	cytoplasm | ribose phosphate diphosphokinase complex	ATP-binding | Kinase | Magnesium | Metal-binding | Nucleotide biosynthesis | Nucleotide-binding | Reference proteome | Transferase		Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis
Haemaphysalis longicornis	44386	A0A9J6GCX7	Lipoyl synthase, mitochondrial		322	Unreviewed	Mitochondrion	protein lipoylation	4 iron, 4 sulfur cluster binding | lipoate synthase activity | metal ion binding	mitochondrion	4Fe-4S | Iron | Iron-sulfur | Metal-binding | Mitochondrion | Reference proteome | S-adenosyl-L-methionine | Transferase		Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Haemaphysalis longicornis	44386	A0A9J6GCW9	alpha-1,2-Mannosidase		942	Unreviewed	Endoplasmic reticulum	carbohydrate metabolic process | endoplasmic reticulum mannose trimming | translation	calcium ion binding | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | structural constituent of ribosome	cytosolic ribosome | endoplasmic reticulum quality control compartment | membrane | ribonucleoprotein complex	Calcium | Endoplasmic reticulum | Glycoprotein | Glycosidase | Hydrolase | Metal-binding | Reference proteome | Ribonucleoprotein | Ribosomal protein | Signal		
Haemaphysalis longicornis	44386	A0A9J6GCR8	Phospholipid-transporting ATPase		1304	Unreviewed	Endomembrane system | Endoplasmic reticulum membrane | Membrane	phospholipid translocation	ATP binding | ATP hydrolysis activity | ATPase-coupled intramembrane lipid transporter activity | magnesium ion binding	endoplasmic reticulum membrane | plasma membrane	ATP-binding | Endoplasmic reticulum | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Reference proteome | Translocase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6GCR7	E3 ubiquitin-protein ligase E3D		312	Unreviewed		proteasome-mediated ubiquitin-dependent protein catabolic process | protein autoubiquitination | protein monoubiquitination | protein polyubiquitination	cyclin binding | ubiquitin conjugating enzyme binding | ubiquitin protein ligase activity	cytosol | nucleus | ubiquitin ligase complex	Reference proteome		E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site
Haemaphysalis longicornis	44386	A0A9J6GCM0	ADP/ATP translocase		299	Unreviewed	Membrane | Mitochondrion inner membrane	mitochondrial ADP transmembrane transport | mitochondrial ATP transmembrane transport | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ATP:ADP antiporter activity	mitochondrial inner membrane	Antiport | Membrane | Mitochondrion | Mitochondrion inner membrane | Reference proteome | Repeat | Transmembrane | Transmembrane helix | Transport		ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane
Haemaphysalis longicornis	44386	A0A9J6GC07	alpha-glucosidase		601	Unreviewed		carbohydrate metabolic process | L-alanine import across plasma membrane | L-leucine import across plasma membrane | phenylalanine transport	alpha-1,4-glucosidase activity | aromatic amino acid transmembrane transporter activity | L-alanine transmembrane transporter activity | L-leucine transmembrane transporter activity	apical plasma membrane | basolateral plasma membrane	Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6GBW1	Sialin		599	Unreviewed	Basolateral cell membrane | Cytoplasmic vesicle, secretory vesicle membrane | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane | Lysosome membrane	carboxylic acid transport | monoatomic anion transport	symporter activity	basolateral plasma membrane | lysosomal membrane | synaptic vesicle membrane	Cell membrane | Cytoplasmic vesicle | Glycoprotein | Lysosome | Membrane | Reference proteome | Symport | Synapse | Transmembrane | Transmembrane helix | Transport		Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties
Haemaphysalis longicornis	44386	A0A9J6GBW0	Ras-related C3 botulinum toxin substrate 1		221	Unreviewed		actin filament bundle assembly | dorsal appendage formation | hemocyte migration | JNK cascade | lamellipodium assembly | melanotic encapsulation of foreign target | mesodermal cell migration | myoblast fusion | phagocytosis, engulfment | positive regulation of wound healing | regulation of adherens junction organization | regulation of axonogenesis | small GTPase-mediated signal transduction | tracheal outgrowth, open tracheal system	GTP binding | GTPase activity | protein kinase binding		GTP-binding | Lipoprotein | Methylation | Nucleotide-binding | Phagocytosis | Prenylation | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6GBA0	Myosin motor domain-containing protein		946	Unreviewed		actin filament organization | actin filament-based movement | determination of left/right symmetry | endocytosis | tissue development	actin filament binding | ATP binding | microfilament motor activity | phosphatidylinositol-4,5-bisphosphate binding	cytoplasm | microvillus | myosin complex | plasma membrane	Actin-binding | ATP-binding | Lipid-binding | Motor protein | Myosin | Nucleotide-binding | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6GB08	Sialin		539	Unreviewed	Basolateral cell membrane | Cytoplasmic vesicle, secretory vesicle membrane | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane | Lysosome membrane	carboxylic acid transport | monoatomic anion transport	symporter activity	basolateral plasma membrane | lysosomal membrane | synaptic vesicle membrane	Cell membrane | Cytoplasmic vesicle | Glycoprotein | Lysosome | Membrane | Reference proteome | Symport | Synapse | Transmembrane | Transmembrane helix | Transport		Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties
Haemaphysalis longicornis	44386	A0A9J6GAK4	ATP-citrate synthase		1084	Unreviewed	Cytoplasm, cytosol	acetyl-CoA biosynthetic process | citrate metabolic process | fatty acid biosynthetic process	ATP binding | ATP citrate synthase activity | metal ion binding	cytosol	Acetylation | ATP-binding | Cytoplasm | Isopeptide bond | Lipid biosynthesis | Lipid metabolism | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Reference proteome | Transferase | Ubl conjugation		Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism
Haemaphysalis longicornis	44386	A0A9J6GAE7	NAD(P)H oxidase (H2O2-forming)		386	Unreviewed	Membrane	cuticle development | defense response to bacterium | hydrogen peroxide catabolic process | molting cycle | post-embryonic animal morphogenesis | superoxide anion generation	metal ion binding | NAD(P)H oxidase H2O2-forming activity | peroxidase activity | superoxide-generating NAD(P)H oxidase activity	NADPH oxidase complex	Calcium | FAD | Flavoprotein | Glycoprotein | Hydrogen peroxide | Membrane | Metal-binding | NADP | Oxidoreductase | Peroxidase | Reference proteome | Repeat | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6GDA1	Asparaginase		365	Unreviewed		L-asparagine catabolic process via L-aspartate | proteolysis	asparaginase activity | beta-aspartyl-peptidase activity	cytoplasm	Autocatalytic cleavage | Hydrolase | Protease | Reference proteome		Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine
Haemaphysalis longicornis	44386	A0A9J6H4G3	Pyridoxal kinase		218	Unreviewed		pyridoxal 5'-phosphate salvage	ATP binding | pyridoxal kinase activity	cytosol	ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Transferase		
Haemaphysalis longicornis	44386	A0A9J6F6P1	Kinesin motor domain-containing protein		257	Unreviewed	Cytoplasm, cytoskeleton	microtubule-based movement | mitotic spindle assembly | spindle elongation	ATP binding | microtubule binding | plus-end-directed microtubule motor activity	mitotic spindle | nucleus | spindle microtubule	ATP-binding | Cytoplasm | Cytoskeleton | Motor protein | Nucleotide-binding | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6H4L8	Methionine aminopeptidase 2		423	Unreviewed	Cytoplasm	proteolysis	initiator methionyl aminopeptidase activity | metal ion binding | metalloaminopeptidase activity	cytoplasm	Aminopeptidase | Coiled coil | Cytoplasm | Hydrolase | Metal-binding | Protease | Reference proteome		Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)
Haemaphysalis longicornis	44386	A0A4Y6HQS2	NADH-ubiquinone oxidoreductase chain 4	nad4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A4Y6HQJ0	NADH-ubiquinone oxidoreductase chain 5	nad5	551	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A4Y6HQI9	NADH-ubiquinone oxidoreductase chain 1	nad1	315	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A4Y6HQI4	NADH-ubiquinone oxidoreductase chain 3	nad3	108	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Haemaphysalis longicornis	44386	A0A4D6D210	Cytochrome c oxidase subunit 1		208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A481MV78	Cytochrome c oxidase subunit 3	cox3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A481MV77	NADH-ubiquinone oxidoreductase chain 1	nad1	315	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A481MV48	NADH-ubiquinone oxidoreductase chain 5	nad5	551	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A481MV47	NADH-ubiquinone oxidoreductase chain 4	nad4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A481MV44	NADH-ubiquinone oxidoreductase chain 4L	nad4L	91	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A481MV43	NADH-ubiquinone oxidoreductase chain 2	nad2	318	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A481MV37	NADH-ubiquinone oxidoreductase chain 3	nad3	112	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Haemaphysalis longicornis	44386	A0A481MV36	Cytochrome c oxidase subunit 2	cox2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A481MV26	ATP synthase subunit a	ATP6	221	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Haemaphysalis longicornis	44386	A0A343VVN4	Cytochrome b	cytb	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Haemaphysalis longicornis	44386	A0A343VVN1	NADH-ubiquinone oxidoreductase chain 4	nad4	446	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A343VVN0	NADH-ubiquinone oxidoreductase chain 5	nad5	551	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A343VVM8	NADH-ubiquinone oxidoreductase chain 3	nad3	108	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Haemaphysalis longicornis	44386	A0A343VVM7	Cytochrome c oxidase subunit 3	cox3	258	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A343VVM4	Cytochrome c oxidase subunit 2	cox2	218	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A343VVM2	NADH-ubiquinone oxidoreductase chain 2	nad2	308	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A2Z6FA39	glutathione transferase	GST	230	Unreviewed		glutathione metabolic process | xenobiotic catabolic process	glutathione transferase activity		Transferase		
Haemaphysalis longicornis	44386	A0A2S0BZ00	protein-glutamine gamma-glutamyltransferase		753	Unreviewed			metal ion binding | protein-glutamine gamma-glutamyltransferase activity		Acyltransferase | Calcium | Metal-binding | Transferase		
Haemaphysalis longicornis	44386	A0A2D1QUC7	NADH:ubiquinone reductase (H(+)-translocating)	nad5	170	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Membrane | Mitochondrion | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A2D1QU84	NADH:ubiquinone reductase (H(+)-translocating)	nad5	170	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Membrane | Mitochondrion | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A2D1QU79	NADH:ubiquinone reductase (H(+)-translocating)	nad5	170	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Membrane | Mitochondrion | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A2D1QU77	NADH:ubiquinone reductase (H(+)-translocating)	nad5	170	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Membrane | Mitochondrion | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A4Y6HR18	NADH-ubiquinone oxidoreductase chain 2	nad2	308	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A4Y6HR19	NADH-ubiquinone oxidoreductase chain 4L	nad4l	84	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A4Y6HRE2	Cytochrome c oxidase subunit 3	cox3	258	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A4Y6HRF3	Cytochrome b	cob	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Haemaphysalis longicornis	44386	A0A9J6F6Q6	BHLH domain-containing protein		295	Unreviewed		axon development | positive regulation of transcription by RNA polymerase II | sensory organ development	DNA-binding transcription factor activity, RNA polymerase II-specific | E-box binding | protein dimerization activity	nucleus	Developmental protein | Differentiation | DNA-binding | Neurogenesis | Nucleus | Reference proteome | Transcription | Transcription regulation		
Haemaphysalis longicornis	44386	A0A9J6F6Q4	BHLH domain-containing protein		212	Unreviewed	Nucleus	axon development | positive regulation of transcription by RNA polymerase II | sensory organ development	DNA-binding transcription factor activity, RNA polymerase II-specific | E-box binding | protein dimerization activity	nucleus	Developmental protein | Differentiation | Neurogenesis | Nucleus | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6F6Q3	Protein kinase domain-containing protein		212	Unreviewed		cell differentiation | intracellular signal transduction | microtubule cytoskeleton organization | spermatogenesis	ATP binding | magnesium ion binding | tau-protein kinase activity	cytoplasm	ATP-binding | Developmental protein | Differentiation | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Spermatogenesis | Transferase | Ubl conjugation		
Haemaphysalis longicornis	44386	A0A9J6G430	Probable ATP-dependent RNA helicase DDX23		727	Unreviewed	Nucleus	mRNA splicing, via spliceosome	ATP binding | hydrolase activity | nucleic acid binding | RNA helicase activity	nucleus	ATP-binding | Helicase | Hydrolase | mRNA processing | mRNA splicing | Nucleotide-binding | Nucleus | Reference proteome		Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA
Haemaphysalis longicornis	44386	A0A9J6F6L5	phosphoinositide phospholipase C		672	Unreviewed		lipid catabolic process | phosphatidylinositol metabolic process | phosphatidylinositol-mediated signaling | release of sequestered calcium ion into cytosol	lyase activity | metal ion binding | phosphatidylinositol-4,5-bisphosphate phospholipase C activity		Disulfide bond | Hydrolase | Lipid degradation | Lipid metabolism | Lyase | Magnesium | Metal-binding | Reference proteome | Transducer		
Haemaphysalis longicornis	44386	A0A9J6F6J3	Plus3 domain-containing protein		338	Unreviewed	Nucleus		DNA binding | RNA polymerase II C-terminal domain phosphoserine binding	Cdc73/Paf1 complex	Coiled coil | Nucleus | Reference proteome | Transcription | Transcription regulation		
Haemaphysalis longicornis	44386	A0A9E8GD16	Superoxide dismutase [Cu-Zn]	SOD4	174	Unreviewed			copper ion binding | superoxide dismutase activity		Antioxidant | Copper | Metal-binding | Oxidoreductase | Signal | Zinc		Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Haemaphysalis longicornis	44386	A0A9E8GAK4	Superoxide dismutase [Cu-Zn]	SOD6	154	Unreviewed			copper ion binding | superoxide dismutase activity		Antioxidant | Copper | Metal-binding | Oxidoreductase | Zinc		Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Haemaphysalis longicornis	44386	A0A9E8G744	Superoxide dismutase [Cu-Zn]	SOD7	208	Unreviewed			copper ion binding | superoxide dismutase activity		Antioxidant | Copper | Disulfide bond | Metal-binding | Oxidoreductase | Signal | Zinc		Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Haemaphysalis longicornis	44386	A0A9E8G724	Superoxide dismutase [Cu-Zn]	SOD5	183	Unreviewed			copper ion binding | superoxide dismutase activity		Antioxidant | Copper | Metal-binding | Oxidoreductase | Signal | Zinc		Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Haemaphysalis longicornis	44386	A0A8K1VXZ9	Dicer-2-like protein	DCL2	1648	Unreviewed		apoptotic DNA fragmentation | pre-miRNA processing | siRNA processing	ATP binding | deoxyribonuclease I activity | helicase activity | ribonuclease III activity | RNA binding	cytoplasm | nucleus | RISC-loading complex	ATP-binding | Helicase | Hydrolase | Nuclease | Nucleotide-binding | Repeat | RNA-binding | RNA-mediated gene silencing		
Haemaphysalis longicornis	44386	A0A8A6W4A9	NADH-ubiquinone oxidoreductase chain 3	nad3	108	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Haemaphysalis longicornis	44386	A0A8A6W484	NADH-ubiquinone oxidoreductase chain 2	nad2	308	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A2D1QU69	NADH:ubiquinone reductase (H(+)-translocating)	nad5	170	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Membrane | Mitochondrion | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A8A6W3I9	Cytochrome c oxidase subunit 3	cox3	258	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A7S5D2J9	Eukaryotic translation initiation factor 3 subunit I		325	Unreviewed	Cytoplasm	formation of cytoplasmic translation initiation complex	RNA binding | translation initiation factor activity	eukaryotic 43S preinitiation complex | eukaryotic 48S preinitiation complex | eukaryotic translation initiation factor 3 complex, eIF3m	Cytoplasm | Initiation factor | Protein biosynthesis | Repeat | WD repeat		Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation
Haemaphysalis longicornis	44386	A0A7L8ZUY1	Cytochrome b	CYTB	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Haemaphysalis longicornis	44386	A0A7L8ZUK5	NADH-ubiquinone oxidoreductase chain 4	ND4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A7L8ZUG0	NADH-ubiquinone oxidoreductase chain 2	ND2	308	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A7L8ZU61	NADH-ubiquinone oxidoreductase chain 5	ND5	551	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A6H2A7E5	B-cell lymphoma	BCL	110	Unreviewed	Membrane	extrinsic apoptotic signaling pathway in absence of ligand | intrinsic apoptotic signaling pathway in response to DNA damage | regulation of apoptotic process | release of cytochrome c from mitochondria	BH domain binding	mitochondrial outer membrane	Apoptosis | Membrane		
Haemaphysalis longicornis	44386	A0A6B7KA41	40S ribosomal protein S27	RPS27	84	Unreviewed		translation	structural constituent of ribosome | zinc ion binding	ribonucleoprotein complex | ribosome	Metal-binding | Ribonucleoprotein | Ribosomal protein | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A513Q1T2	Glycogen synthase kinase 3 beta	GSK-3	413	Unreviewed		cell differentiation | gamete generation | negative regulation of canonical Wnt signaling pathway | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | regulation of microtubule cytoskeleton organization | signal transduction	ATP binding | protein serine/threonine kinase activity	axon | cytosol | nucleus	ATP-binding | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A4Y6HSL2	NADH-ubiquinone oxidoreductase chain 5	nad5	551	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A4Y6HS31	Cytochrome b	cob	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Haemaphysalis longicornis	44386	A0A4Y6HRT1	NADH-ubiquinone oxidoreductase chain 4L	nad4l	84	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A4Y6HRS7	NADH-ubiquinone oxidoreductase chain 2	nad2	308	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A4Y6HRP8	ATP synthase subunit a	atp6	221	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Haemaphysalis longicornis	44386	A0A8A6W2U1	NADH-ubiquinone oxidoreductase chain 5	nad5	551	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A9J6H4L7	Presenilin		122	Unreviewed	Endoplasmic reticulum membrane | Golgi apparatus membrane	amyloid-beta formation | calcium ion homeostasis | membrane protein ectodomain proteolysis | Notch signaling pathway | protein processing	aspartic endopeptidase activity, intramembrane cleaving	endoplasmic reticulum membrane | gamma-secretase complex | Golgi membrane	Endoplasmic reticulum | Golgi apparatus | Hydrolase | Membrane | Notch signaling pathway | Protease | Reference proteome | Transmembrane | Transmembrane helix		Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors
Haemaphysalis longicornis	44386	A0A2D1QU66	NADH:ubiquinone reductase (H(+)-translocating)	nad5	170	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Membrane | Mitochondrion | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A2D1QU60	NADH:ubiquinone reductase (H(+)-translocating)	nad5	170	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Membrane | Mitochondrion | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	C8YL72	Calreticulin	CRT	410	Unreviewed	Endoplasmic reticulum lumen	ERAD pathway | protein folding	calcium ion binding | carbohydrate binding | unfolded protein binding	endoplasmic reticulum lumen | endoplasmic reticulum membrane	Calcium | Chaperone | Disulfide bond | Endoplasmic reticulum | Lectin | Metal-binding | Repeat | Signal | Zinc		Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER
Haemaphysalis longicornis	44386	B1B6U6	Kynurenine 3-monooxygenase	HlK3H	466	Unreviewed	Mitochondrion | Membrane	'de novo' NAD+ biosynthetic process from L-tryptophan | anthranilate metabolic process | kynurenine metabolic process | L-tryptophan catabolic process | quinolinate biosynthetic process	FAD binding | kynurenine 3-monooxygenase activity	mitochondrial outer membrane	FAD | Flavoprotein | Membrane | Mitochondrion | Monooxygenase | NADP | Oxidoreductase | Pyridine nucleotide biosynthesis | Transmembrane | Transmembrane helix		Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid
Haemaphysalis longicornis	44386	A0AA49QBL6	Alpha-tubulin N-acetyltransferase		319	Unreviewed		neuron development | regulation of microtubule cytoskeleton organization	tubulin N-acetyltransferase activity	microtubule	Acyltransferase | Transferase		Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released
Haemaphysalis longicornis	44386	A0A9J6HDB4	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase		212	Unreviewed	Golgi apparatus membrane	oligosaccharide biosynthetic process | protein N-linked glycosylation	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity | metal ion binding	Golgi membrane | Golgi stack	Disulfide bond | Glycoprotein | Glycosyltransferase | Golgi apparatus | Manganese | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6HBW5	Cysteine protease		505	Unreviewed	Cytoplasm	aggrephagy | autophagosome assembly | mitophagy | piecemeal microautophagy of the nucleus | protein processing | protein transport	cysteine-type endopeptidase activity | protein-phosphatidylethanolamide deconjugating activity	cytoplasm	Autophagy | Cytoplasm | Hydrolase | Protease | Protein transport | Reference proteome | Thiol protease | Transport		Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins
Haemaphysalis longicornis	44386	A0A9J6HBC5	Crossover junction endonuclease MUS81		279	Unreviewed	Nucleus	DNA catabolic process | double-strand break repair via break-induced replication | mitotic intra-S DNA damage checkpoint signaling | resolution of meiotic recombination intermediates	3'-flap endonuclease activity | crossover junction DNA endonuclease activity | DNA binding | metal ion binding	Holliday junction resolvase complex | nucleus	DNA damage | DNA recombination | DNA repair | Endonuclease | Hydrolase | Magnesium | Metal-binding | Nuclease | Nucleus | Reference proteome		Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI)
Haemaphysalis longicornis	44386	A0A9J6HAY1	Crossover junction endonuclease MUS81		451	Unreviewed	Nucleus	DNA catabolic process | double-strand break repair via break-induced replication | mitotic intra-S DNA damage checkpoint signaling | resolution of meiotic recombination intermediates	3'-flap endonuclease activity | crossover junction DNA endonuclease activity | DNA binding | metal ion binding	Holliday junction resolvase complex | nucleus	DNA damage | DNA recombination | DNA repair | Endonuclease | Hydrolase | Magnesium | Metal-binding | Nuclease | Nucleus | Reference proteome		Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI)
Haemaphysalis longicornis	44386	A0A9J6HAF1	E3 ubiquitin protein ligase		203	Unreviewed	Nucleus	chromatin organization | protein ubiquitination	ubiquitin protein ligase activity | zinc ion binding	HULC complex | nucleus	Chromatin regulator | Coiled coil | Metal-binding | Nucleus | Reference proteome | Signal | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6H9I0	Dihydrolipoyl dehydrogenase		516	Unreviewed		2-oxoglutarate metabolic process | cellular respiration	dihydrolipoyl dehydrogenase (NADH) activity | flavin adenine dinucleotide binding	mitochondrion | oxoglutarate dehydrogenase complex | pyruvate dehydrogenase complex	Disulfide bond | FAD | Flavoprotein | NAD | Nucleotide-binding | Oxidoreductase | Redox-active center | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6H9G4	Suppressor of cytokine signaling 7		431	Unreviewed	Cell membrane | Cytoplasm | Nucleus	intracellular signal transduction | negative regulation of signal transduction | phosphatidylinositol phosphate biosynthetic process | protein ubiquitination | regulation of growth	1-phosphatidylinositol-3-kinase regulator activity	cytoplasm | nucleus | phosphatidylinositol 3-kinase complex | plasma membrane	Cell membrane | Cytoplasm | Growth regulation | Membrane | Nucleus | Reference proteome | SH2 domain | Signal transduction inhibitor | Ubl conjugation pathway		Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA
Haemaphysalis longicornis	44386	A0A9J6H990	Eukaryotic translation initiation factor 3 subunit K		516	Unreviewed	Cytoplasm	formation of cytoplasmic translation initiation complex | regulation of translational initiation	heme binding | oxygen binding | ribosome binding | RNA binding | translation initiation factor activity	eukaryotic 43S preinitiation complex | eukaryotic 48S preinitiation complex | eukaryotic translation initiation factor 3 complex	Cytoplasm | Initiation factor | Protein biosynthesis | Reference proteome		Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation
Haemaphysalis longicornis	44386	A0A9J6H8N2	isocitrate dehydrogenase (NADP(+))		156	Unreviewed		glyoxylate cycle | isocitrate metabolic process | NADP+ metabolic process | tricarboxylic acid cycle	isocitrate dehydrogenase (NADP+) activity | magnesium ion binding | NAD binding	cytosol | mitochondrion | peroxisome	Glyoxylate bypass | Magnesium | Manganese | Metal-binding | NADP | Oxidoreductase | Reference proteome | Signal | Tricarboxylic acid cycle		
Haemaphysalis longicornis	44386	A0A9J6H8J7	Serine/threonine-protein kinase RIO3		572	Unreviewed	Cytoplasm	defense response to virus | innate immune response | ribosome biogenesis	ATP binding | metal ion binding | protein serine/threonine kinase activity	cytoplasm	Antiviral defense | ATP-binding | Coiled coil | Cytoplasm | Immunity | Innate immunity | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Reference proteome | Ribosome biogenesis | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6H8E2	Mitochondrial 2-oxodicarboxylate carrier		334	Unreviewed	Mitochondrion inner membrane			mitochondrial inner membrane	Membrane | Mitochondrion | Mitochondrion inner membrane | Reference proteome | Repeat | Signal | Transmembrane | Transmembrane helix | Transport		Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle
Haemaphysalis longicornis	44386	A0A9J6H8A5	Ras-related protein Rab-30		208	Unreviewed	Cytoplasmic vesicle, autophagosome membrane | Golgi apparatus, cis-Golgi network | Golgi apparatus, trans-Golgi network membrane | Lysosome | Membrane		G protein activity | GTP binding | metal ion binding	autophagosome membrane | cytoplasmic vesicle | Golgi apparatus | lysosome	Cytoplasm | Cytoplasmic vesicle | Golgi apparatus | GTP-binding | Hydrolase | Lipoprotein | Lysosome | Magnesium | Membrane | Metal-binding | Methylation | Nucleotide-binding | Prenylation | Reference proteome		The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins. Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner. Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection
Haemaphysalis longicornis	44386	A0A9J6H892	DNA-(apurinic or apyrimidinic site) endonuclease 2		464	Unreviewed		base-excision repair	DNA binding | DNA-(apurinic or apyrimidinic site) endonuclease activity | double-stranded DNA 3'-5' DNA exonuclease activity | phosphoric diester hydrolase activity | zinc ion binding	nucleus	Hydrolase | Magnesium | Manganese | Metal-binding | Nucleus | Reference proteome | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6H7S6	Mitochondrial 2-oxodicarboxylate carrier		305	Unreviewed	Mitochondrion inner membrane			mitochondrial inner membrane	Membrane | Mitochondrion | Mitochondrion inner membrane | Reference proteome | Repeat | Transmembrane | Transmembrane helix | Transport		Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle
Haemaphysalis longicornis	44386	A0A9J6H7G4	Pyridoxal kinase		499	Unreviewed		pyridoxal 5'-phosphate salvage	ATP binding | pyridoxal kinase activity	cytosol	ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Transferase		
Haemaphysalis longicornis	44386	A0A9J6H6S6	RING-type domain-containing protein		166	Unreviewed		apoptotic process | negative regulation of apoptotic process | positive regulation of protein ubiquitination | protein K48-linked ubiquitination | regulation of cell cycle	caspase binding | cysteine-type endopeptidase inhibitor activity | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | ubiquitin protein ligase activity | ubiquitin protein ligase binding | zinc ion binding	cytosol | nucleus | perinuclear region of cytoplasm	Apoptosis | Metal-binding | Reference proteome | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6H6K0	DNA replication licensing factor MCM4		828	Unreviewed	Nucleus	DNA strand elongation involved in DNA replication | double-strand break repair via break-induced replication | mitotic DNA replication initiation	ATP binding | hydrolase activity | single-stranded DNA binding | single-stranded DNA helicase activity	MCM complex | nucleus	ATP-binding | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Reference proteome		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Haemaphysalis longicornis	44386	A0A9J6H5W7	Citramalyl-CoA lyase, mitochondrial		428	Unreviewed	Mitochondrion	regulation of cobalamin metabolic process	(S)-citramalyl-CoA lyase activity | hydrolase activity | malate synthase activity | metal ion binding	mitochondrion	Acetylation | Hydrolase | Lyase | Magnesium | Metal-binding | Mitochondrion | Reference proteome | Transferase | Transit peptide		Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro
Haemaphysalis longicornis	44386	A0A9J6H5M6	Presenilin		150	Unreviewed	Endoplasmic reticulum membrane | Golgi apparatus membrane	amyloid-beta formation | calcium ion homeostasis | membrane protein ectodomain proteolysis | Notch signaling pathway | protein processing	aspartic endopeptidase activity, intramembrane cleaving	endoplasmic reticulum membrane | gamma-secretase complex | Golgi membrane	Endoplasmic reticulum | Golgi apparatus | Hydrolase | Membrane | Notch signaling pathway | Protease | Reference proteome | Transmembrane | Transmembrane helix		Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors
Haemaphysalis longicornis	44386	A0A9J6H5A8	U8 snoRNA-decapping enzyme		171	Unreviewed	Nucleus, nucleolus | Nucleus, nucleoplasm	mRNA catabolic process | nucleotide metabolic process | sno(s)RNA catabolic process	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity | IDP phosphatase activity | phosphodiesterase decapping endonuclease activity | snoRNA binding	nucleolus | nucleoplasm	Hydrolase | Nucleotide metabolism | Nucleus | Reference proteome | RNA-binding		
Haemaphysalis longicornis	44386	A0A9J6H509	non-specific serine/threonine protein kinase		1059	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	anatomical structure morphogenesis | hippo signaling | negative regulation of developmental process | negative regulation of protein import into nucleus | regulation of cell morphogenesis | regulation of dendrite morphogenesis | regulation of signal transduction | system development	ATP binding | metal ion binding | protein serine/threonine kinase activity	apical part of cell | cell periphery | centrosome | cytoplasm	ATP-binding | Cytoplasm | Cytoskeleton | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6H500	Tissue-resident T-cell transcription regulator protein ZNF683		913	Unreviewed	Nucleus	adaptive immune response | cell fate commitment | innate immune response | regulation of immune system process | regulation of multicellular organismal process	DNA-binding transcription repressor activity, RNA polymerase II-specific | N-methyltransferase activity | protein methyltransferase activity | RNA polymerase II cis-regulatory region sequence-specific DNA binding | S-adenosylmethionine-dependent methyltransferase activity | zinc ion binding	cytoplasm | nucleus	Adaptive immunity | DNA-binding | Immunity | Innate immunity | Metal-binding | Nucleus | Reference proteome | Repeat | Transcription | Transcription regulation | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6H4P3	Aurora kinase		409	Unreviewed	Midbody	chromatin organization | chromosome condensation | cytokinetic process | mitotic sister chromatid segregation	ATP binding | protein serine/threonine kinase activity	midbody	ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6H4M4	Decapping nuclease		636	Unreviewed	Nucleus	NAD-cap decapping | nuclear-transcribed mRNA catabolic process	metal ion binding | mRNA 5'-diphosphatase activity | nuclease activity | nucleotide binding | RNA binding | S-adenosylmethionine-dependent methyltransferase activity	cytosol | nucleus	Hydrolase | Membrane | Metal-binding | Nuclease | Nucleotide-binding | Nucleus | Reference proteome | RNA-binding | Transmembrane | Transmembrane helix		Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA
Haemaphysalis longicornis	44386	E0WD58	Cytochrome c oxidase subunit 1	COI	243	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	G3FSW7	Cytochrome c oxidase subunit 1	COI	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	G3FSX1	Cytochrome c oxidase subunit 1	COI	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	I1WDH5	Cytochrome c oxidase subunit 1	COI	175	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A2D1QU58	NADH:ubiquinone reductase (H(+)-translocating)	nad5	170	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Membrane | Mitochondrion | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A2D1QU54	NADH:ubiquinone reductase (H(+)-translocating)	nad5	170	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Membrane | Mitochondrion | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A2D1QU53	NADH:ubiquinone reductase (H(+)-translocating)	nad5	170	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Membrane | Mitochondrion | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A2D1QU46	NADH:ubiquinone reductase (H(+)-translocating)	nad5	170	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Membrane | Mitochondrion | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A286R6U7	Fructose-bisphosphate aldolase	FBA	363	Unreviewed		glycolytic process	fructose-bisphosphate aldolase activity		Glycolysis | Lyase | Reference proteome | Schiff base		
Haemaphysalis longicornis	44386	A0A1X9RQE2	Cytochrome c oxidase subunit 2	cox2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A1X9RQD7	ATP synthase subunit a	atp6	221	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Haemaphysalis longicornis	44386	A0A1X9RQD2	NADH-ubiquinone oxidoreductase chain 4L	nad4L	91	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A1X9RQC0	Cytochrome c oxidase subunit 3	cox3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A1X9RQB9	NADH-ubiquinone oxidoreductase chain 2	nad2	318	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A1X9RQB8	NADH-ubiquinone oxidoreductase chain 4	nad4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A1X9RQB7	NADH-ubiquinone oxidoreductase chain 1	nad1	315	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A1X9RQB5	Cytochrome b	CYTB	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Haemaphysalis longicornis	44386	A0A2D1QU64	NADH:ubiquinone reductase (H(+)-translocating)	nad5	170	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Membrane | Mitochondrion | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis longicornis	44386	A0A146J914	thioredoxin-dependent peroxiredoxin	HlPrx(II)	197	Unreviewed		cell redox homeostasis | hydrogen peroxide catabolic process | removal of superoxide radicals	thioredoxin peroxidase activity	cytosol	Antioxidant | Disulfide bond | Oxidoreductase | Peroxidase | Redox-active center		Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively
Haemaphysalis longicornis	44386	A0A0F6PA36	Cytochrome c oxidase subunit 1	COI	217	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6PA33	Cytochrome c oxidase subunit 1	COI	208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9Y4	Cytochrome c oxidase subunit 1	COI	208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9Q7	Cytochrome c oxidase subunit 1	COI	201	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	V5J2F1	Cytochrome c oxidase subunit 1	COI	235	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	V5J282	Cytochrome c oxidase subunit 1	COI	235	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	U3RHB4	Cytochrome c oxidase subunit 1	COI	247	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	Q9MD10	Cytochrome c oxidase subunit 1	COI	264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	Q6WSQ1	Calreticulin		410	Unreviewed	Endoplasmic reticulum lumen	ERAD pathway | protein folding	calcium ion binding | carbohydrate binding | unfolded protein binding	endoplasmic reticulum lumen | endoplasmic reticulum membrane	Calcium | Chaperone | Disulfide bond | Endoplasmic reticulum | Lectin | Metal-binding | Repeat | Signal | Zinc		Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER
Haemaphysalis longicornis	44386	Q0KKA6	Cytosol aminopeptidase	HlLAP	525	Unreviewed		proteolysis	manganese ion binding | metalloaminopeptidase activity	cytoplasm	Aminopeptidase | Hydrolase | Protease		Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status
Haemaphysalis longicornis	44386	K4Q301	non-specific serine/threonine protein kinase	HlTOR	2523	Unreviewed		negative regulation of macroautophagy | negative regulation of macromolecule metabolic process | negative regulation of mitotic cell cycle | positive regulation of cell cycle | positive regulation of DNA-templated transcription | positive regulation of reproductive process | TORC1 signaling	ATP binding | protein serine/threonine kinase activity | protein-containing complex binding	cytoplasm | nucleus | TORC1 complex | TORC2 complex	ATP-binding | Cell cycle | Kinase | Nucleotide-binding | Repeat | Transferase		
Haemaphysalis longicornis	44386	I2B1G9	Cytochrome c oxidase subunit 1	COI	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	I1WDH6	Cytochrome c oxidase subunit 1	COI	175	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0N6X2B1	Muscle LIM protein	MLP	106	Unreviewed	Nucleus	muscle organ development | muscle tissue development | sarcomere organization	actinin binding | metal ion binding | structural constituent of muscle	nucleus | Z disc	LIM domain | Metal-binding | Myogenesis | Nucleus | Repeat | Zinc		
Haemaphysalis longicornis	44386	A0A9J6G413	Aminopeptidase		908	Unreviewed	Cell membrane | Membrane	peptide catabolic process | proteolysis	metalloaminopeptidase activity | peptide binding | zinc ion binding	cytoplasm | extracellular space | plasma membrane	Aminopeptidase | Glycoprotein | Hydrolase | Membrane | Metal-binding | Metalloprotease | Protease | Reference proteome | Signal-anchor | Transmembrane | Transmembrane helix | Zinc		
Haemaphysalis longicornis	44386	A0A9J6FTG2	Bifunctional lysine-specific demethylase and histidyl-hydroxylase		316	Unreviewed	Nucleus, nucleolus	ribosome biogenesis	histone H3K36me/H3K36me2 demethylase activity | histone H3K4 demethylase activity | iron ion binding | peptidyl-histidine dioxygenase activity	nucleolus	Dioxygenase | Iron | Metal-binding | Nucleus | Oxidoreductase | Reference proteome | Ribosome biogenesis | Transcription | Transcription regulation		Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles
Haemaphysalis longicornis	44386	A0A9J6G3Z2	(3R)-3-hydroxyacyl-CoA dehydrogenase		248	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Haemaphysalis longicornis	44386	A0A678NQI5	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A678NQI4	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A678NQI3	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A4Y6HSJ6	Cytochrome c oxidase subunit 1	cox1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A4Y6GT52	Cytochrome c oxidase subunit 1	COI	224	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A4Y6GSJ0	Cytochrome c oxidase subunit 1	COI	224	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A481MV46	Cytochrome b	Cytb	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Haemaphysalis longicornis	44386	A0A481MV27	Cytochrome c oxidase subunit 1	cox1	507	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A411KZF9	Cytochrome c oxidase subunit 1	COI	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A3G2CK98	Cytochrome c oxidase subunit 1	COI	230	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A3G2CK97	Cytochrome c oxidase subunit 1	COI	231	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A3G2CK96	Cytochrome c oxidase subunit 1	COI	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A3G2CK95	Cytochrome c oxidase subunit 1	COI	217	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A3G2CK63	Cytochrome c oxidase subunit 1	COI	231	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A3G2CK30	Cytochrome c oxidase subunit 1	COI	217	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A3G2CK29	Cytochrome c oxidase subunit 1	COI	217	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A3G2CK28	Cytochrome c oxidase subunit 1	COI	217	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A3G2CK22	Cytochrome c oxidase subunit 1	COI	216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A346LU37	Cytochrome c oxidase subunit 1	COI	197	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A346LU14	Cytochrome c oxidase subunit 1	COI	197	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A343VVM3	Cytochrome c oxidase subunit 1	cox1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A2D1QUB6	Cytochrome c oxidase subunit 1	cox1	258	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A2D1QUB2	Cytochrome c oxidase subunit 1	cox1	245	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A2D1QUA8	Cytochrome c oxidase subunit 1	cox1	258	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A2D1QU52	Cytochrome c oxidase subunit 1	cox1	258	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A2D1QU51	Cytochrome c oxidase subunit 1	cox1	258	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A2D1QU43	Cytochrome c oxidase subunit 1	cox1	258	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A678NT67	Cytochrome c oxidase subunit 1	COI	221	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A678NT70	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A678NW94	Cytochrome c oxidase subunit 1	COI	221	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A678NZV7	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A8K0ZE84	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A8J9WW54	Cytochrome c oxidase subunit 1	COX1	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A8A6W434	Cytochrome c oxidase subunit 1	cox1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A7U0REX2	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	333	Unreviewed		glucose metabolic process | glycolytic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | NAD binding | NADP binding	cytosol	Glycolysis | NAD | Nucleotide-binding | Oxidoreductase		
Haemaphysalis longicornis	44386	A0A7T4U4Z4	Cytochrome c oxidase subunit 1	COI	221	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A7T4PVE9	Cytochrome c oxidase subunit 1	COI	221	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A7T4PV69	Cytochrome c oxidase subunit 1	COI	221	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A7S5D156	Phosphotransferase		474	Unreviewed		glucose metabolic process | glycolytic process | intracellular glucose homeostasis	ATP binding | D-glucose binding | fructokinase activity | glucokinase activity	cytosol | mitochondrion	ATP-binding | Glycolysis | Kinase | Nucleotide-binding | Transferase		Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate
Haemaphysalis longicornis	44386	A0A7L8ZUQ5	Cytochrome c oxidase subunit 1	COX1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A6M4WDY0	Cytochrome c oxidase subunit 1	COX1	221	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A6M4W6P6	Cytochrome c oxidase subunit 1	COX1	221	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A6M4W3R6	Cytochrome c oxidase subunit 1	COX1	221	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A6M4W3F6	Cytochrome c oxidase subunit 1	COX1	221	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A2D1QU31	Cytochrome c oxidase subunit 1	cox1	258	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A6H0QVC5	Cytochrome c oxidase subunit 1	cox1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A6G6A0S4	Cytochrome c oxidase subunit 1	COX1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A6G6A0L8	Cytochrome c oxidase subunit 1	COX1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A6G5ZZX5	Cytochrome c oxidase subunit 1	COX1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A6G5ZZI3	Cytochrome c oxidase subunit 1	COX1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A6G5ZZG4	Cytochrome c oxidase subunit 1	COX1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A6G5ZYQ3	Cytochrome c oxidase subunit 1	COX1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A6B9XMT3	Cytochrome c oxidase subunit 1	coxI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A678QH40	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A678QH39	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A678PD82	Cytochrome c oxidase subunit 1	COI	217	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A678P4E5	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A678P4E1	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A678NZW3	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A6G6A170	Cytochrome c oxidase subunit 1	COX1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A8K0ZEI2	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A2D1QU28	Cytochrome c oxidase subunit 1	cox1	258	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A1X9RQB3	Cytochrome c oxidase subunit 1	cox1	507	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A9J6H0D4	arginine--tRNA ligase		1326	Unreviewed	Cytoplasmic vesicle, clathrin-coated vesicle | Golgi apparatus | Membrane, clathrin-coated pit	arginyl-tRNA aminoacylation | clathrin coat assembly | clathrin-dependent endocytosis | locomotion | synaptic vesicle budding from presynaptic endocytic zone membrane	1-phosphatidylinositol binding | arginine-tRNA ligase activity | ATP binding | clathrin heavy chain binding | phosphatidylinositol-4,5-bisphosphate binding | SNARE binding	clathrin-coated pit | clathrin-coated vesicle | extrinsic component of presynaptic endocytic zone membrane | Golgi apparatus | synaptic vesicle	Aminoacyl-tRNA synthetase | ATP-binding | Coated pit | Cytoplasmic vesicle | Endocytosis | Golgi apparatus | Ligase | Membrane | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6GYR4	Flavin-containing monooxygenase		365	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Reference proteome | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Haemaphysalis longicornis	44386	A0A9J6GUS1	PRKCA-binding protein		409	Unreviewed	Cytoplasm, cytoskeleton | Cytoplasm, perinuclear region | Membrane | Postsynaptic density | Synapse, synaptosome	dendritic spine maintenance | intracellular protein transport | positive regulation of receptor internalization | receptor clustering | regulation of Arp2/3 complex-mediated actin nucleation	actin binding | metal ion binding | phospholipid binding | protein domain specific binding | protein kinase C binding	cytoskeleton | neuron projection | perinuclear region of cytoplasm | plasma membrane | postsynaptic density | postsynaptic early endosome | synaptic vesicle | trans-Golgi network membrane	Actin-binding | Calcium | Cytoplasm | Cytoskeleton | Lipoprotein | Membrane | Metal-binding | Palmitate | Phosphoprotein | Reference proteome | Synapse | Synaptosome | Zinc		Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function
Haemaphysalis longicornis	44386	A0A9J6GUN1	3-hydroxyacyl-CoA dehydrogenase type-2		247	Unreviewed		androgen metabolic process | estrogen metabolic process | fatty acid metabolic process	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity | androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity | estradiol 17-beta-dehydrogenase [NAD(P)+] activity	mitochondrion	Oxidoreductase | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6GP48	Phosphatidylserine decarboxylase proenzyme, mitochondrial		458	Unreviewed	Mitochondrion inner membrane	phosphatidylethanolamine biosynthetic process | protein autoprocessing	phosphatidylserine decarboxylase activity	mitochondrial inner membrane	Decarboxylase | Lipid biosynthesis | Lipid metabolism | Lyase | Membrane | Mitochondrion | Mitochondrion inner membrane | Phospholipid biosynthesis | Phospholipid metabolism | Pyruvate | Reference proteome | Signal | Transmembrane | Transmembrane helix | Zymogen		Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane
Haemaphysalis longicornis	44386	A0A9J6GD30	Ketimine reductase mu-crystallin		184	Unreviewed			hormone binding | pyrroline-2-carboxylate reductase activity | thiomorpholine-carboxylate dehydrogenase activity	cytoplasm	Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6GCV5	Flavin-containing monooxygenase		503	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Reference proteome | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Haemaphysalis longicornis	44386	A0A9J6GCU1	ATP-dependent 6-phosphofructokinase		892	Unreviewed	Cytoplasm	canonical glycolysis | fructose 1,6-bisphosphate metabolic process | fructose 6-phosphate metabolic process	6-phosphofructokinase activity | AMP binding | ATP binding | fructose-6-phosphate binding | identical protein binding | metal ion binding | monosaccharide binding	6-phosphofructokinase complex	Allosteric enzyme | ATP-binding | Cytoplasm | Glycolysis | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Reference proteome | Transferase		Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
Haemaphysalis longicornis	44386	A0A9J6GBB2	Flavin-containing monooxygenase		595	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Reference proteome | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Haemaphysalis longicornis	44386	A0A9J6G6S4	Lysosomal dipeptide transporter MFSD1		373	Unreviewed	Lysosome membrane		transmembrane transporter activity	lysosomal membrane	Lysosome | Membrane | Reference proteome | Transmembrane | Transmembrane helix | Transport		Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis
Haemaphysalis longicornis	44386	A0A9J6G5E8	Glucosylceramidase		613	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Membrane | Reference proteome | Signal | Sphingolipid metabolism | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6FXC7	glycerophosphocholine cholinephosphodiesterase		251	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Haemaphysalis longicornis	44386	A0A9J6FX48	Lysine-specific histone demethylase		802	Unreviewed	Chromosome | Nucleus	DNA repair-dependent chromatin remodeling | negative regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | positive regulation of multicellular organismal process | positive regulation of neural precursor cell proliferation | positive regulation of transcription by RNA polymerase II | regulation of neurogenesis	chromatin binding | enzyme binding | FAD-dependent H3K4me/H3K4me3 demethylase activity | flavin adenine dinucleotide binding | histone H3K9 demethylase activity | MRF binding | RNA binding | RNA polymerase II-specific DNA-binding transcription factor binding | transcription coactivator activity | transcription corepressor activity	chromatin | nucleus	Acetylation | Chromatin regulator | Chromosome | Coiled coil | Developmental protein | FAD | Flavoprotein | Isopeptide bond | Nucleus | Oxidoreductase | Phosphoprotein | Reference proteome | Repressor | Transcription | Transcription regulation | Ubl conjugation		Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3
Haemaphysalis longicornis	44386	A0A9J6FVZ5	glycerophosphocholine cholinephosphodiesterase		148	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Haemaphysalis longicornis	44386	A0A9J6FP37	RING-type E3 ubiquitin-protein ligase PPIL2		1508	Unreviewed	Nucleus	glutaminyl-tRNA aminoacylation | mRNA processing | protein folding | protein ubiquitination | RNA splicing	ATP binding | glutamine-tRNA ligase activity | peptidyl-prolyl cis-trans isomerase activity | ubiquitin protein ligase activity	aminoacyl-tRNA synthetase multienzyme complex | cytosol | spliceosomal complex	Acetylation | Aminoacyl-tRNA synthetase | ATP-binding | Coiled coil | Isopeptide bond | Ligase | Membrane | mRNA processing | mRNA splicing | Nucleotide-binding | Nucleus | Protein biosynthesis | Reference proteome | Spliceosome | Transferase | Transmembrane | Transmembrane helix | Ubl conjugation | Ubl conjugation pathway		Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs
Haemaphysalis longicornis	44386	A0A9J6FLG9	[G-protein-coupled receptor] kinase		2037	Unreviewed	Cytoplasm, myofibril, sarcomere, A band | Cytoplasm, myofibril, sarcomere, I band | Nucleus	anatomical structure morphogenesis | cell differentiation | positive regulation of locomotion | positive regulation of sarcomere organization | positive regulation of striated muscle contraction | signal transduction	actin binding | ATP binding | calmodulin binding | G protein-coupled receptor kinase activity | metal ion binding	A band | I band | nucleus	ATP-binding | Calcium | Calmodulin-binding | Coiled coil | Cytoplasm | Disulfide bond | Immunoglobulin domain | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Repeat | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6FB48	Laminin subunit alpha-1		3593	Unreviewed	Secreted, extracellular space, extracellular matrix, basement membrane	animal organ morphogenesis | axon development | basement membrane organization | cell adhesion | cell migration | response to stress | tissue development		cytoplasm | laminin-1 complex | laminin-10 complex	Basement membrane | Cell adhesion | Coiled coil | Disulfide bond | Extracellular matrix | Glycoprotein | Laminin EGF-like domain | Phosphoprotein | Reference proteome | Repeat | Secreted | Signal		
Haemaphysalis longicornis	44386	A0A9J6G1F2	Hormone-sensitive lipase		460	Unreviewed	Cell membrane | Cytoplasm, cytosol | Lipid droplet | Membrane, caveola	cholesterol metabolic process | triglyceride catabolic process	monoacylglycerol lipase activity | sterol ester esterase activity | triacylglycerol lipase activity	caveola | cytosol | lipid droplet	Cell membrane | Cholesterol metabolism | Cytoplasm | Hydrolase | Lipid degradation | Lipid droplet | Lipid metabolism | Membrane | Reference proteome | Steroid metabolism | Sterol metabolism		
Haemaphysalis longicornis	44386	A0A9J6FKZ6	Trifunctional enzyme subunit alpha, mitochondrial		673	Unreviewed	Mitochondrion inner membrane	fatty acid beta-oxidation	enoyl-CoA hydratase activity | long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity | NAD+ binding | transferase activity	mitochondrial fatty acid beta-oxidation multienzyme complex | mitochondrial inner membrane	Acetylation | Fatty acid metabolism | Lipid metabolism | Lyase | Membrane | Methylation | Mitochondrion | Mitochondrion inner membrane | Multifunctional enzyme | NAD | Oxidoreductase | Phosphoprotein | Reference proteome | Transferase | Transit peptide		
Haemaphysalis longicornis	44386	A0A9J6FG89	Alanine--glyoxylate aminotransferase 2, mitochondrial		420	Unreviewed	Mitochondrion	glyoxylate catabolic process | L-alanine catabolic process, by transamination	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity | alanine-glyoxylate transaminase activity | beta-alanine:pyruvate transaminase activity | pyridoxal phosphate binding	mitochondrion	Aminotransferase | Pyridoxal phosphate | Reference proteome | Transferase		Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure
Haemaphysalis longicornis	44386	A0A9J6FDM6	Notch		2405	Unreviewed	Cell membrane | Nucleus | Secreted | Target cell membrane	axon guidance | cell fate specification | embryonic organ development | exocytosis | formation of animal organ boundary | gland development | larval development | negative regulation of multicellular organismal process | nervous system process | Notch signaling pathway | positive regulation of cell population proliferation | positive regulation of multicellular organismal process | regulation of cell differentiation | regulation of cell-cell adhesion | regulation of transcription by RNA polymerase II | reproductive structure development | sex differentiation	calcium ion binding	cell surface | cytoplasm | endomembrane system | extracellular region | host cell presynaptic membrane | nucleoplasm | other organism cell membrane | plasma membrane | receptor complex | RNA polymerase II transcription regulator complex	Activator | ANK repeat | Calcium | Cell membrane | Developmental protein | Differentiation | Disulfide bond | EGF-like domain | Exocytosis | Glycoprotein | Membrane | Metal-binding | Neurotoxin | Notch signaling pathway | Nucleus | Presynaptic neurotoxin | Receptor | Reference proteome | Repeat | Secreted | Signal | Target cell membrane | Target membrane | Toxin | Transcription | Transcription regulation | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	Q8IT89	Tropomyosin		284	Reviewed					Coiled coil | Repeat		Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction
Haemaphysalis longicornis	44386	C0HMD5	Haemaphysalin		162	Reviewed	Secreted		serine-type endopeptidase inhibitor activity | toxin activity	extracellular region	Blood coagulation cascade inhibiting toxin | Disulfide bond | Glycoprotein | Hemostasis impairing toxin | Protease inhibitor | Secreted | Serine protease inhibitor | Signal | Toxin		Anticoagulant protein (PubMed:15711755, PubMed:16169873). Inhibits activation of host plasma kallikrein-kinin system by interfering with reciprocal activation between coagulation factor XII (F12) and prekallikrein (KLKB1) without affecting their amidolytic activities (PubMed:15711755, PubMed:16169873)
Haemaphysalis longicornis	44386	Q969A1	Troponin I-like protein	p27/30	200	Reviewed		modulation of process of another organism | muscle contraction		troponin complex	Coiled coil		Inhibits endothelial cell proliferation and angiogenesis in a vertebrate host (PubMed:16631826). Probably required for efficient blood feeding on vertebrate hosts (Probable)
Haemaphysalis longicornis	44386	B6ZIW0	Thrombin inhibitor hemalin		141	Reviewed	Secreted		serine-type endopeptidase inhibitor activity | toxin activity	extracellular space	Blood coagulation cascade inhibiting toxin | Cell adhesion impairing toxin | Disulfide bond | Hemostasis impairing toxin | Platelet aggregation inhibiting toxin | Protease inhibitor | Repeat | Secreted | Serine protease inhibitor | Signal | Toxin		Anticoagulant protein that may inhibit thrombin by binding to its exosite I. Also inhibits the amidolytic activity of trypsin (tested on the substrate S-2238). The recombinant protein delays plasma clotting time and inhibits both thrombin-induced fibrinogen clotting and thrombin-induced platelet aggregation in a dose-dependent manner. May be an anticoagulant for the common pathway of blood coagulation
Haemaphysalis longicornis	44386	B2MW54	Longicornsin	sGDLP	78	Reviewed	Secreted	defense response to bacterium | defense response to fungus | innate immune response | killing of cells of another organism		extracellular region	Antibiotic | Antimicrobial | Cleavage on pair of basic residues | Cytolysis | Defensin | Direct protein sequencing | Disulfide bond | Fungicide | Hemolysis | Immunity | Innate immunity | Secreted | Signal		Has antibacterial activity against the Gram-positive bacteria S.aureus ATCC2592 (MIC=0.8 ug/ml), S.aureus 6A (MIC=0.8 ug/ml) and S.aureus 15A (MIC=1.6 ug/ml), and against the Gram-negative bacteria E.coli ATCC 25922 (MIC=3.2 ug/ml), E.coli 23A (MIC=6.4 ug/ml), E.coli 27A (MIC=6.4 ug/ml), P.aeruginosa 3A (MIC=3.2 ug/ml), P.aeruginosa 7A (MIC=0.8 ug/ml) and H.pylori NCTC11637 (MIC=6.4 ug/ml). Has antifungal activity against C.albidus ATCC2002 (MIC=25.6 ug/ml). Very low hemolytic activity against rabbit erythrocytes
Haemaphysalis longicornis	44386	D4QD81	Longistatin	A01M12	156	Reviewed	Secreted | Cytoplasm	proteolysis | venom-mediated fibrinogenolysis | venom-mediated fibrinolysis	calcium ion binding | serine-type peptidase activity | toxin activity	cytoplasm | extracellular space	Blood coagulation cascade inhibiting toxin | Calcium | Cytoplasm | Hemostasis impairing toxin | Hydrolase | Metal-binding | Protease | Repeat | Secreted | Serine protease | Signal | Toxin		Anticoagulant and fibrinolytic protease that modulates blood feeding of ticks on vertebrate hosts (PubMed:21423674). Degrades host fibrinogen and delays fibrin clot formation (PubMed:21423674). Promotes lysis of fibrin clots in the host by activating host plasminogen in the presence of soluble fibrin (PubMed:21423674, PubMed:21925150). Binds Ca(2+) (PubMed:19968997, PubMed:23296609). Hydrolyzes serine protease-specific substrates (PubMed:22206819). Required for the formation of a blood pool, an accumulation of blood and tissue fluid developed at the tick's feeding site (PubMed:21423674). Blocks activation of host AGER/RAGE (PubMed:25401185). Reduces AGER/RAGE-dependent production of reactive oxygen species (ROS) in human endothelial cells (PubMed:25401185). Prevents AGER/RAGE-dependent activation of NF-kappa-B and suppresses expression of adhesion molecules, such as VCAM1, ICAM1 and SELE, and secretion of cytokines, such as CSF3/GCSF and TGF-beta, in human endothelial cells (PubMed:25401185). Suppresses RAGE/AGER-mediated migration of mouse peritoneal resident cells (PubMed:25401185). Reduces AGER/RAGE-mediated inflammation in mice tissues (PubMed:25401185)
Haemaphysalis longicornis	44386	A0A9J6H163	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		201	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase | Reference proteome		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Haemaphysalis longicornis	44386	A0A9J6H3Q5	glycerophosphocholine cholinephosphodiesterase		381	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Haemaphysalis longicornis	44386	A0A9J6H5I5	glycerophosphocholine cholinephosphodiesterase		120	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Haemaphysalis longicornis	44386	A0A0F6P9N1	Cytochrome c oxidase subunit 1	COI	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A1B1UZ10	Cytochrome c oxidase subunit 1	COI	267	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6PA37	Cytochrome c oxidase subunit 1	COI	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6PA35	Cytochrome c oxidase subunit 1	COI	200	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6PA34	Cytochrome c oxidase subunit 1	COI	202	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6PA31	Cytochrome c oxidase subunit 1	COI	210	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9Y7	Cytochrome c oxidase subunit 1	COI	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9Y0	Cytochrome c oxidase subunit 1	COI	208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9X4	Cytochrome c oxidase subunit 1	COI	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9X1	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9W9	Cytochrome c oxidase subunit 1	COI	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9W7	Cytochrome c oxidase subunit 1	COI	206	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9W6	Cytochrome c oxidase subunit 1	COI	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9W4	Cytochrome c oxidase subunit 1	COI	208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A2D1QU20	Cytochrome c oxidase subunit 1	cox1	258	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A9J6G404	Protein hedgehog		319	Unreviewed	Cell membrane	anatomical structure morphogenesis | cell fate specification | cell-cell signaling | protein autoprocessing | regulation of gene expression | segment polarity determination | smoothened signaling pathway	calcium ion binding | morphogen activity | patched binding | peptidase activity | transferase activity	extracellular space | plasma membrane	Autocatalytic cleavage | Calcium | Cell membrane | Developmental protein | Hydrolase | Lipoprotein | Membrane | Metal-binding | Morphogen | Palmitate | Protease | Reference proteome | Segmentation polarity protein | Transferase		The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product. Once cleaved, the C-product has no signaling activity and diffuses from the cell
Haemaphysalis longicornis	44386	A0A0F6P9V6	Cytochrome c oxidase subunit 1	COI	217	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9S3	Cytochrome c oxidase subunit 1	COI	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9S0	Cytochrome c oxidase subunit 1	COI	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9R7	Cytochrome c oxidase subunit 1	COI	191	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9R4	Cytochrome c oxidase subunit 1	COI	210	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9R0	Cytochrome c oxidase subunit 1	COI	223	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9Q6	Cytochrome c oxidase subunit 1	COI	154	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9Q4	Cytochrome c oxidase subunit 1	COI	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9Q0	Cytochrome c oxidase subunit 1	COI	224	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9P9	Cytochrome c oxidase subunit 1	COI	220	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9P7	Cytochrome c oxidase subunit 1	COI	207	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9N9	Cytochrome c oxidase subunit 1	COI	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9N5	Cytochrome c oxidase subunit 1	COI	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9V8	Cytochrome c oxidase subunit 1	COI	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A8K0ZFZ1	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A0F6P9W1	Cytochrome c oxidase subunit 1	COI	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A8K1VZ45	ribonuclease III	DCL1	2130	Unreviewed	Cytoplasm	anatomical structure morphogenesis | apoptotic DNA fragmentation | developmental process involved in reproduction | post-transcriptional gene silencing | pre-miRNA processing | response to stress | siRNA processing | system development	ATP binding | deoxyribonuclease I activity | helicase activity | metal ion binding | ribonuclease III activity | RNA binding	cytosol | nucleus | RISC-loading complex	ATP-binding | Cytoplasm | Endonuclease | Helicase | Hydrolase | Magnesium | Manganese | Metal-binding | Nuclease | Nucleotide-binding | Phosphoprotein | Repeat | RNA-binding | RNA-mediated gene silencing		
Haemaphysalis longicornis	44386	A0A9J6FVC5	Ubiquitin carboxyl-terminal hydrolase		356	Unreviewed		protein K48-linked deubiquitination | proteolysis	cysteine-type carboxypeptidase activity | cysteine-type deubiquitinase activity | histone deubiquitinase activity | K48-linked deubiquitinase activity | K48-linked polyubiquitin modification-dependent protein binding	cell periphery | cytosol	Hydrolase | Protease | Reference proteome | Thiol protease | Ubl conjugation pathway		Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover
Haemaphysalis longicornis	44386	A0A9J6FUX2	(3R)-3-hydroxyacyl-CoA dehydrogenase		624	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6FUS0	Flavin-containing monooxygenase		474	Unreviewed	Endoplasmic reticulum membrane		flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Membrane | Monooxygenase | NADP | Oxidoreductase | Reference proteome | Transmembrane | Transmembrane helix		Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine
Haemaphysalis longicornis	44386	A0A9J6FUQ8	Glycogen debranching enzyme		681	Unreviewed	Cytoplasm	glycogen biosynthetic process | glycogen catabolic process	4-alpha-glucanotransferase activity | amylo-alpha-1,6-glucosidase activity	cytoplasm	Cytoplasm | Glycogen biosynthesis | Glycosidase | Glycosyltransferase | Hydrolase | Multifunctional enzyme | Reference proteome | Transferase		Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation
Haemaphysalis longicornis	44386	A0A9J6FUN0	4-hydroxyphenylpyruvate dioxygenase		353	Unreviewed	Cytoplasm | Endoplasmic reticulum membrane | Golgi apparatus membrane	L-phenylalanine catabolic process | L-tyrosine catabolic process	4-hydroxyphenylpyruvate dioxygenase activity | metal ion binding | protein homodimerization activity	endoplasmic reticulum membrane | Golgi membrane	Cytoplasm | Dioxygenase | Endoplasmic reticulum | Golgi apparatus | Iron | Membrane | Metal-binding | Oxidoreductase | Phenylalanine catabolism | Reference proteome | Repeat | Tyrosine catabolism		Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism
Haemaphysalis longicornis	44386	A0A9J6FUB4	Ubiquitin carboxyl-terminal hydrolase 36		1298	Unreviewed	Nucleus, nucleolus	protein deubiquitination | proteolysis | regulation of apoptotic process	cysteine-type deubiquitinase activity	cytosol | nucleolus	Hydrolase | Protease | Reference proteome | Thiol protease | Ubl conjugation pathway		
Haemaphysalis longicornis	44386	A0A9J6FUA3	Multiple inositol polyphosphate phosphatase 1		492	Unreviewed	Cell membrane		acid phosphatase activity | bisphosphoglycerate 3-phosphatase activity | inositol phosphate phosphatase activity	plasma membrane	Cell membrane | Disulfide bond | Glycoprotein | Hydrolase | Membrane | Reference proteome | Signal | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6FU91	DNA ligase		923	Unreviewed	Nucleus	cell division | DNA biosynthetic process | DNA recombination | double-strand break repair | lagging strand elongation	ATP binding | DNA binding | DNA ligase (ATP) activity | zinc ion binding	DNA ligase III-XRCC1 complex	ATP-binding | Cell cycle | Cell division | DNA damage | DNA recombination | DNA repair | DNA replication | Ligase | Magnesium | Metal-binding | Nucleotide-binding | Nucleus | Reference proteome | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6FTR0	Eukaryotic translation initiation factor 3 subunit B		721	Unreviewed	Cytoplasm	formation of cytoplasmic translation initiation complex	RNA binding | translation initiation factor activity | translation initiation factor binding	eukaryotic 43S preinitiation complex | eukaryotic 48S preinitiation complex | eukaryotic translation initiation factor 3 complex	Coiled coil | Cytoplasm | Initiation factor | Protein biosynthesis | Reference proteome | RNA-binding | WD repeat		Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome
Haemaphysalis longicornis	44386	A0A9J6FTL3	Protein kinase domain-containing protein		389	Unreviewed	Nucleus	cell division | G2/M transition of mitotic cell cycle | mitotic G2 DNA damage checkpoint signaling | positive regulation of cell cycle process | positive regulation of meiotic cell cycle	ATP binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	nucleus	ATP-binding | Cell cycle | Cell division | Kinase | Mitosis | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia
Haemaphysalis longicornis	44386	A0A9J6FSS4	MH1 domain-containing protein		325	Unreviewed	Cytoplasm | Nucleus	anatomical structure morphogenesis | BMP signaling pathway | cell differentiation | dauer larval development | SMAD protein signal transduction	DNA-binding transcription factor activity, RNA polymerase II-specific | I-SMAD binding | metal ion binding | RNA polymerase II cis-regulatory region sequence-specific DNA binding	cytoplasm | heteromeric SMAD protein complex	Coiled coil | Cytoplasm | DNA-binding | Metal-binding | Nucleus | Reference proteome | Transcription | Transcription regulation | Zinc		
Haemaphysalis longicornis	44386	A0A9J6FSB5	Probable methylthioribulose-1-phosphate dehydratase		485	Unreviewed	Cytoplasm	L-methionine salvage from methylthioadenosine	methylthioribulose 1-phosphate dehydratase activity | zinc ion binding	cytoplasm	Amino-acid biosynthesis | Cytoplasm | Lyase | Metal-binding | Methionine biosynthesis | Reference proteome | Zinc		Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death
Haemaphysalis longicornis	44386	A0A9J6FS87	ADAM10 endopeptidase		794	Unreviewed		membrane protein ectodomain proteolysis | Notch signaling pathway	metal ion binding | metalloendopeptidase activity	plasma membrane	Cleavage on pair of basic residues | Disulfide bond | Membrane | Metal-binding | Reference proteome | Signal | Transmembrane | Transmembrane helix | Zinc		
Haemaphysalis longicornis	44386	A0A9J6FRS4	non-specific serine/threonine protein kinase		838	Unreviewed		actomyosin structure organization | cortical actin cytoskeleton organization | embryonic morphogenesis | mitotic cytokinesis | regulation of cell junction assembly | Rho protein signal transduction	ATP binding | Rho-dependent protein serine/threonine kinase activity	cytoplasm | cytoskeleton	ATP-binding | Coiled coil | Kinase | Nucleotide-binding | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6FRF4	Uncharacterized protein		1584	Unreviewed	Nucleus, nucleolus	carbohydrate metabolic process | chitin catabolic process | mRNA processing | ribosome biogenesis | RNA splicing	chitin binding | chitinase activity | RNA binding	extracellular region | nucleolus | spliceosomal complex	Chitin-binding | mRNA processing | mRNA splicing | Nucleus | Reference proteome | Ribonucleoprotein | RNA-binding | Signal | Spliceosome		Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding
Haemaphysalis longicornis	44386	A0A9J6FRE1	Angiotensin-converting enzyme		774	Unreviewed		proteolysis	carboxypeptidase activity | metal ion binding | metallopeptidase activity | peptidyl-dipeptidase activity	membrane	Carboxypeptidase | Disulfide bond | Glycoprotein | Hydrolase | Metal-binding | Metalloprotease | Protease | Reference proteome | Signal | Zinc		
Haemaphysalis longicornis	44386	A0A9J6FQF1	Probable methylthioribulose-1-phosphate dehydratase		266	Unreviewed	Cytoplasm	L-methionine salvage from methylthioadenosine	methylthioribulose 1-phosphate dehydratase activity | zinc ion binding	cytoplasm	Amino-acid biosynthesis | Cytoplasm | Lyase | Metal-binding | Methionine biosynthesis | Reference proteome | Zinc		Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death
Haemaphysalis longicornis	44386	A0A9J6FQB4	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial		479	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	4 iron, 4 sulfur cluster binding | FMN binding | metal ion binding | NAD binding | NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	4Fe-4S | Electron transport | Flavoprotein | FMN | Iron | Iron-sulfur | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | NAD | Reference proteome | Respiratory chain | Transit peptide | Translocase | Transport		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I
Haemaphysalis longicornis	44386	A0A9J6FPU3	Ubiquitin-conjugating enzyme E2 S		235	Unreviewed		anaphase-promoting complex-dependent catabolic process | cell division | exit from mitosis	ATP binding | ubiquitin conjugating enzyme activity		ATP-binding | Cell cycle | Cell division | Nucleotide-binding | Reference proteome | Transferase | Ubl conjugation pathway		
Haemaphysalis longicornis	44386	A0A9J6FPM1	non-specific serine/threonine protein kinase		459	Unreviewed	Cytoplasm, cytoskeleton	actomyosin structure organization | cortical actin cytoskeleton organization | embryonic morphogenesis | mitotic cytokinesis | regulation of cell junction assembly | Rho protein signal transduction	ATP binding | metal ion binding | Rho-dependent protein serine/threonine kinase activity | small GTPase binding	cytoplasm | cytoskeleton	ATP-binding | Coiled coil | Cytoplasm | Cytoskeleton | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase | Zinc		
Haemaphysalis longicornis	44386	A0A9J6FNV7	Presenilin		450	Unreviewed	Endoplasmic reticulum membrane | Golgi apparatus membrane	amyloid-beta formation | calcium ion homeostasis | membrane protein ectodomain proteolysis | Notch signaling pathway | protein processing	aspartic endopeptidase activity, intramembrane cleaving	endoplasmic reticulum membrane | gamma-secretase complex | Golgi membrane	Endoplasmic reticulum | Golgi apparatus | Hydrolase | Membrane | Notch signaling pathway | Protease | Reference proteome | Transmembrane | Transmembrane helix		Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors
Haemaphysalis longicornis	44386	A0A9J6FNU3	Ubiquitin carboxyl-terminal hydrolase		578	Unreviewed	Nucleus	chromatin organization | protein deubiquitination | ubiquitin-dependent protein catabolic process	cysteine-type deubiquitinase activity	cytoplasm | nucleus	Chromatin regulator | Hydrolase | Nucleus | Protease | Reference proteome | Thiol protease | Ubl conjugation pathway		Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK118ub1). Mediates bisymmetric organization of the PR-DUB complex and is involved in association with nucleosomes to mediate deubiquitination. Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Polycomb group (PcG) protein
Haemaphysalis longicornis	44386	A0A9J6FNT2	Presenilin		414	Unreviewed	Endomembrane system | Endoplasmic reticulum membrane | Golgi apparatus membrane	amyloid-beta formation | calcium ion homeostasis | membrane protein ectodomain proteolysis | Notch signaling pathway | protein processing	aspartic endopeptidase activity, intramembrane cleaving	endoplasmic reticulum membrane | gamma-secretase complex | Golgi membrane	Endoplasmic reticulum | Golgi apparatus | Hydrolase | Membrane | Notch signaling pathway | Protease | Reference proteome | Transmembrane | Transmembrane helix		Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors
Haemaphysalis longicornis	44386	A0A9J6FNK9	Nitrilase and fragile histidine triad fusion protein NitFhit		469	Unreviewed		nucleobase-containing compound metabolic process	bis(5'-adenosyl)-triphosphatase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | nucleotide binding		Hydrolase | Multifunctional enzyme | Nucleotide-binding | Reference proteome		Cleaves A-5'-PPP-5'A to yield AMP and ADP
Haemaphysalis longicornis	44386	A0A9J6FN46	Transporter		1354	Unreviewed	Membrane	amino acid import across plasma membrane | proteolysis	amino acid:sodium symporter activity | glycine transmembrane transporter activity | L-amino acid transmembrane transporter activity | metal ion binding | metalloendopeptidase activity	plasma membrane	Disulfide bond | Membrane | Metal-binding | Reference proteome | Sodium | Symport | Transmembrane | Transmembrane helix | Transport		
Haemaphysalis longicornis	44386	A0A9J6FMW1	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase		281	Unreviewed	Golgi apparatus membrane	oligosaccharide biosynthetic process | protein N-linked glycosylation	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity | metal ion binding	Golgi membrane | Golgi stack	Disulfide bond | Glycoprotein | Glycosyltransferase | Golgi apparatus | Manganese | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6FMP4	Heat shock protein 83		1264	Unreviewed	Cell membrane | Cytoplasm | Nucleus	cellular response to calcium ion	ATP binding | ATP hydrolysis activity | ATP-dependent protein folding chaperone | metal ion binding | unfolded protein binding	cytoplasm | nucleus | plasma membrane | protein-containing complex	ATP-binding | Calcium | Cell membrane | Chaperone | Cytoplasm | Membrane | Metal-binding | Nucleotide-binding | Nucleus | Reference proteome | Repeat | Stress response		
Haemaphysalis longicornis	44386	A0A9J6FVE5	Cysteine protease		489	Unreviewed	Cytoplasm	aggrephagy | autophagosome assembly | mitophagy | piecemeal microautophagy of the nucleus | protein processing | protein transport	cysteine-type endopeptidase activity | protein-phosphatidylethanolamide deconjugating activity	cytoplasm	Autophagy | Cytoplasm | Hydrolase | Protease | Protein transport | Reference proteome | Thiol protease | Transport		Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins
Haemaphysalis longicornis	44386	A0A9J6FMI7	non-specific protein-tyrosine kinase		902	Unreviewed	Cell junction, focal adhesion | Cell membrane | Cell projection | Cytoplasm	animal organ morphogenesis | positive regulation of cell population proliferation | system development	ATP binding | non-membrane spanning protein tyrosine kinase activity	cell projection | cytoplasm | focal adhesion | plasma membrane	ATP-binding | Cell junction | Cell membrane | Cell projection | Cytoplasm | Kinase | Membrane | Nucleotide-binding | Reference proteome | SH2 domain | Transferase | Tyrosine-protein kinase		
Haemaphysalis longicornis	44386	A0A9J6FVP6	DNA-directed primase/polymerase protein		477	Unreviewed		error-prone translesion synthesis | mitochondrial DNA replication | replication fork processing | response to UV	chromatin binding | DNA-directed DNA polymerase activity	mitochondrial matrix | nucleus	DNA-directed DNA polymerase | Nucleotidyltransferase | Reference proteome | Transferase		
Haemaphysalis longicornis	44386	A0A9J6FXY8	Alpha-1,3/1,6-mannosyltransferase ALG2		422	Unreviewed	Endoplasmic reticulum membrane		GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity | GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | Glycosyltransferase | Membrane | Reference proteome | Transferase | Transmembrane | Transmembrane helix		Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate
Haemaphysalis longicornis	44386	A0A8K0ZKN0	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis longicornis	44386	A0A9J6G3X1	Formimidoyltransferase-cyclodeaminase		515	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole | Golgi apparatus	L-histidine metabolic process	folic acid binding | formimidoyltetrahydrofolate cyclodeaminase activity | glutamate formimidoyltransferase activity	centriole | Golgi apparatus	Cytoplasm | Cytoskeleton | Folate-binding | Golgi apparatus | Histidine metabolism | Lyase | Multifunctional enzyme | Reference proteome | Transferase		Binds and promotes bundling of vimentin filaments originating from the Golgi
Haemaphysalis longicornis	44386	A0A9J6G3T1	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase		1183	Unreviewed	Cytoplasm, cytosol	inositol metabolic process | inositol phosphate biosynthetic process	5-diphosphoinositol pentakisphosphate 1-kinase activity | ATP binding | inositol hexakisphosphate kinase activity | phosphatase activity	cytosol	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Reference proteome | Transferase		Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6)
Haemaphysalis longicornis	44386	A0A9J6G3M4	Vitamin K-dependent protein C		281	Unreviewed	Endoplasmic reticulum | Golgi apparatus | Secreted	hemostasis | proteolysis	serine-type endopeptidase activity	endoplasmic reticulum | extracellular space | Golgi apparatus	Disulfide bond | Endoplasmic reticulum | Glycoprotein | Golgi apparatus | Hemostasis | Hydrolase | Protease | Reference proteome | Secreted | Serine protease		Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function
Haemaphysalis longicornis	44386	A0A9J6G3E2	CCR4-NOT transcription complex subunit 4		218	Unreviewed	Cytoplasm | Nucleus	protein ubiquitination	RNA binding | ubiquitin protein ligase activity | zinc ion binding	CCR4-NOT complex | cytosol | nucleus	Coiled coil | Cytoplasm | Metal-binding | Methylation | Nucleus | Phosphoprotein | Reference proteome | RNA-binding | Transferase | Ubl conjugation | Ubl conjugation pathway | Zinc | Zinc-finger		Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy
Haemaphysalis longicornis	44386	A0A9J6G3A6	Matrix metalloproteinase-14		808	Unreviewed	Cytoplasm | Melanosome	collagen catabolic process | extracellular matrix organization | proteolysis	metalloendopeptidase activity | zinc ion binding	cytoplasm | extracellular matrix | extracellular space	Calcium | Cytoplasm | Disulfide bond | Hydrolase | Metal-binding | Metalloprotease | Phosphoprotein | Protease | Reference proteome | Repeat | Signal | Zinc | Zymogen		
Haemaphysalis longicornis	44386	A0A9J6G2L0	cyclin-dependent kinase		324	Unreviewed		G1/S transition of mitotic cell cycle | regulation of G2/M transition of mitotic cell cycle | regulation of gene expression | signal transduction	ATP binding | cyclin binding | cyclin-dependent protein serine/threonine kinase activity	cyclin-dependent protein kinase holoenzyme complex | cytoplasm | nucleus	ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6G2I4	V-type proton ATPase subunit a		992	Unreviewed	Membrane | Nucleus	vacuolar acidification	ATPase binding | DNA binding | DNA-binding transcription factor activity, RNA polymerase II-specific | proton-transporting ATPase activity, rotational mechanism	nucleus | plasma membrane | proton-transporting V-type ATPase, V0 domain | vacuolar proton-transporting V-type ATPase complex	Coiled coil | DNA-binding | Homeobox | Hydrogen ion transport | Ion transport | Membrane | Nucleus | Reference proteome | Transmembrane | Transmembrane helix | Transport		Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase
Haemaphysalis longicornis	44386	A0A9J6G2I1	DNA replication licensing factor MCM6		718	Unreviewed	Nucleus	DNA replication initiation | double-strand break repair via break-induced replication | mitotic DNA replication	ATP binding | hydrolase activity | single-stranded 3'-5' DNA helicase activity | single-stranded DNA binding	MCM complex | nucleus	ATP-binding | Cell cycle | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Reference proteome		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Haemaphysalis longicornis	44386	A0A9J6G2B8	Aurora kinase		275	Unreviewed	Midbody	chromatin organization | chromosome condensation | cytokinetic process | mitotic sister chromatid segregation	ATP binding | protein serine/threonine kinase activity	midbody	ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6G224	Phosphatidylserine synthase		484	Unreviewed	Endoplasmic reticulum membrane	phosphatidylserine biosynthetic process	L-serine-phosphatidylethanolamine phosphatidyltransferase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | Lipid biosynthesis | Lipid metabolism | Membrane | Phospholipid biosynthesis | Phospholipid metabolism | Reference proteome | Transferase | Transmembrane | Transmembrane helix		Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine
Haemaphysalis longicornis	44386	A0A9J6G204	N-terminal methionine N(alpha)-acetyltransferase NatE		180	Unreviewed	Cytoplasm	mitotic sister chromatid cohesion	protein N-terminal-methionine acetyltransferase activity	NatA complex	Acyltransferase | Cytoplasm | Reference proteome | Transferase		
Haemaphysalis longicornis	44386	A0A9J6G1Z9	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase		262	Unreviewed	Endoplasmic reticulum membrane	dolichol-linked oligosaccharide biosynthetic process	glycosyltransferase activity | metal ion binding | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | Glycosyltransferase | Magnesium | Membrane | Metal-binding | Reference proteome | Transferase | Transmembrane | Transmembrane helix		UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane
Haemaphysalis longicornis	44386	A0A9J6G1Y0	E3 ubiquitin-protein ligase		762	Unreviewed	Cytoplasm	negative regulation of smoothened signaling pathway | positive regulation of receptor-mediated endocytosis | protein ubiquitination | regulation of dendrite morphogenesis | ubiquitin-dependent protein catabolic process	sodium channel inhibitor activity | ubiquitin protein ligase activity	cytoplasm	Cytoplasm | Phosphoprotein | Reference proteome | Repeat | Transferase | Ubl conjugation | Ubl conjugation pathway		
Haemaphysalis longicornis	44386	A0A9J6G1X5	NAD(P)H oxidase (H2O2-forming)		890	Unreviewed	Membrane	cuticle development | defense response to bacterium | hydrogen peroxide catabolic process | molting cycle | post-embryonic animal morphogenesis | superoxide anion generation	calcium ion binding | NAD(P)H oxidase H2O2-forming activity | peroxidase activity | superoxide-generating NAD(P)H oxidase activity	NADPH oxidase complex	Calcium | FAD | Flavoprotein | Glycoprotein | Hydrogen peroxide | Membrane | Metal-binding | NADP | Oxidoreductase | Peroxidase | Reference proteome | Repeat | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6G1J3	Phospholipase A2		310	Unreviewed	Secreted	arachidonate secretion | lipid catabolic process | phospholipid metabolic process	calcium ion binding | phospholipase A2 activity	extracellular region	Calcium | Disulfide bond | Hydrolase | Lipid metabolism | Metal-binding | Reference proteome | Secreted | Zymogen		
Haemaphysalis longicornis	44386	A0A9J6G1D0	Max-like protein X		203	Unreviewed	Cytoplasm | Nucleus	positive regulation of transcription by RNA polymerase II	DNA-binding transcription factor activity, RNA polymerase II-specific | DNA-binding transcription factor binding | protein dimerization activity | RNA polymerase II cis-regulatory region sequence-specific DNA binding	cytoplasm | nucleoplasm	Activator | Coiled coil | Cytoplasm | DNA-binding | Nucleus | Phosphoprotein | Reference proteome | Repressor | Transcription | Transcription regulation		Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation
Haemaphysalis longicornis	44386	A0A9J6G1A3	Cyclin-dependent kinase 7		417	Unreviewed	Nucleus	cell division | positive regulation of transcription by RNA polymerase II	ATP binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	cytoplasm | transcription factor TFIIK complex	ATP-binding | Cell cycle | Cell division | Kinase | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6G0T2	Myosin motor domain-containing protein		467	Unreviewed		actin filament organization | actin filament-based movement | determination of left/right symmetry | endocytosis	actin filament binding | ATP binding | microfilament motor activity | phosphatidylinositol-4,5-bisphosphate binding	cytoplasm | microvillus | myosin complex | plasma membrane	Actin-binding | ATP-binding | Lipid-binding | Motor protein | Myosin | Nucleotide-binding | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6G0N9	DNA replication licensing factor MCM6		163	Unreviewed	Nucleus	DNA replication initiation | double-strand break repair via break-induced replication | mitotic DNA replication	ATP binding | hydrolase activity | single-stranded 3'-5' DNA helicase activity | single-stranded DNA binding	MCM complex | nucleus	ATP-binding | Cell cycle | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Reference proteome		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Haemaphysalis longicornis	44386	A0A9J6G0M8	E3 ubiquitin-protein ligase CBL		756	Unreviewed	Cytoplasm	cell surface receptor signaling pathway | regulation of signaling	calcium ion binding | phosphotyrosine residue binding | receptor tyrosine kinase binding | SH3 domain binding | ubiquitin protein ligase activity | zinc ion binding	cytoplasm | membrane raft | plasma membrane	Calcium | Cytoplasm | Metal-binding | Reference proteome | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome
Haemaphysalis longicornis	44386	A0A9J6FZ43	Sulfide:quinone oxidoreductase, mitochondrial		298	Unreviewed	Mitochondrion	sulfide oxidation, using sulfide:quinone oxidoreductase	FAD binding | glutathione-dependent sulfide quinone oxidoreductase activity | quinone binding | sulfide:quinone oxidoreductase activity	mitochondrion	FAD | Flavoprotein | Mitochondrion | Oxidoreductase | Quinone | Reference proteome | Transit peptide		Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione
Haemaphysalis longicornis	44386	A0A9J6FYJ5	NAD(P)H-hydrate epimerase		276	Unreviewed			metal ion binding | NAD(P)HX epimerase activity | nucleotide binding	mitochondrion	Isomerase | Metal-binding | NAD | NADP | Nucleotide-binding | Potassium | Reference proteome		Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX
Haemaphysalis longicornis	44386	A0A9J6FYF0	Adenomatous polyposis coli protein		2197	Unreviewed		cell fate specification | cell migration | negative regulation of canonical Wnt signaling pathway | negative regulation of microtubule depolymerization | nervous system development | pattern specification process | Wnt signaling pathway	beta-catenin binding | gamma-catenin binding | microtubule binding	beta-catenin destruction complex | catenin complex | cytoplasmic microtubule	Reference proteome | Wnt signaling pathway		
Haemaphysalis longicornis	44386	A0A9J6FYE6	Serine/threonine-protein kinase receptor		1190	Unreviewed	Membrane	BMP signaling pathway	ATP binding | metal ion binding | transforming growth factor beta receptor activity	plasma membrane | receptor complex	ATP-binding | Glycoprotein | Kinase | Magnesium | Manganese | Membrane | Metal-binding | Nucleotide-binding | Receptor | Reference proteome | Serine/threonine-protein kinase | Signal | Transferase | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6FYB0	ADAM10 endopeptidase		759	Unreviewed		membrane protein ectodomain proteolysis | Notch signaling pathway	metal ion binding | metalloendopeptidase activity	plasma membrane	Cleavage on pair of basic residues | Membrane | Metal-binding | Reference proteome | Signal | Transmembrane | Transmembrane helix | Zinc		
Haemaphysalis longicornis	44386	A0A9J6FXZ4	RING-box protein 2		105	Unreviewed	Cytoplasm | Nucleus	intracellular signal transduction | proteasome-mediated ubiquitin-dependent protein catabolic process	NEDD8 ligase activity | ubiquitin protein ligase activity | zinc ion binding	Cul5-RING ubiquitin ligase complex | cytosol | nucleus	Acetylation | Cytoplasm | Metal-binding | Nucleus | Reference proteome | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6FX66	Phosphoinositide phospholipase C		402	Unreviewed	Cytoplasm	gamma-aminobutyric acid signaling pathway | lipid catabolic process | phosphatidylinositol metabolic process | phosphatidylinositol-mediated signaling | regulation of synaptic transmission, GABAergic | release of sequestered calcium ion into cytosol	lyase activity | metal ion binding | phosphatidylinositol-4,5-bisphosphate phospholipase C activity	cytoplasm	Cytoplasm | Disulfide bond | Hydrolase | Lipid degradation | Lipid metabolism | Lyase | Magnesium | Metal-binding | Reference proteome | Transducer		
Haemaphysalis longicornis	44386	A0A9J6FME1	serine--tRNA ligase		426	Unreviewed		seryl-tRNA aminoacylation	ATP binding | serine-tRNA ligase activity		Aminoacyl-tRNA synthetase | ATP-binding | Coiled coil | Ligase | Nucleotide-binding | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6FQV2	DNA topoisomerase 2		1630	Unreviewed	Nucleus	DNA topological change | resolution of meiotic recombination intermediates | sister chromatid segregation	ATP binding | DNA binding | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | metal ion binding	nucleus	ATP-binding | DNA-binding | Isomerase | Magnesium | Metal-binding | Nucleotide-binding | Nucleus | Reference proteome | Topoisomerase		Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks
Haemaphysalis longicornis	44386	A0A9J6FM16	E3 ubiquitin-protein ligase		314	Unreviewed	Cytoplasm, cytosol	protein autoubiquitination | ubiquitin-dependent protein catabolic process | Wnt signaling pathway	poly-ADP-D-ribose binding | ubiquitin protein ligase activity | zinc ion binding	cytosol | nucleus	Cytoplasm | Metal-binding | Reference proteome | Transferase | Ubl conjugation pathway | Wnt signaling pathway | Zinc | Zinc-finger		E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation
Haemaphysalis longicornis	44386	A0A9J6FGY8	Aconitate hydratase, mitochondrial		796	Unreviewed	Mitochondrion	tricarboxylic acid cycle	4 iron, 4 sulfur cluster binding | aconitate hydratase activity | metal ion binding	cytosol | mitochondrion	Iron | Iron-sulfur | Lyase | Metal-binding | Mitochondrion | Reference proteome | Transit peptide | Tricarboxylic acid cycle		Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Haemaphysalis longicornis	44386	A0A9J6FGP4	KIND domain-containing protein		459	Unreviewed	Cell membrane | Cytoplasm, cytoskeleton | Cytoplasmic vesicle membrane	actin filament network formation | actin filament polymerization | actin nucleation | cleavage furrow formation | establishment of meiotic spindle localization | Golgi vesicle transport | polar body extrusion after meiotic divisions | protein transport	actin binding | microtubule binding	cell cortex | cytoplasmic vesicle membrane | cytoskeleton | plasma membrane	Actin-binding | Cell membrane | Cytoplasm | Cytoplasmic vesicle | Cytoskeleton | Membrane | Protein transport | Reference proteome | Repeat | Transport		
Haemaphysalis longicornis	44386	A0A9J6FGL5	Alanine--tRNA ligase		1079	Unreviewed		alanyl-tRNA aminoacylation	alanine-tRNA ligase activity | aminoacyl-tRNA deacylase activity | ATP binding | tRNA binding | zinc ion binding	mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Coiled coil | Cytoplasm | Ligase | Metal-binding | Nucleotide-binding | Protein biosynthesis | Reference proteome | RNA-binding | tRNA-binding | Zinc		Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain
Haemaphysalis longicornis	44386	A0A9J6FGH8	Flap endonuclease 1	Fen1	352	Unreviewed	Nucleus, nucleolus | Nucleus, nucleoplasm | Mitochondrion	base-excision repair | DNA replication, removal of RNA primer	5'-3' exonuclease activity | 5'-flap endonuclease activity | DNA binding | magnesium ion binding | manganese ion binding | RNA-DNA hybrid ribonuclease activity	mitochondrion | nucleolus | nucleoplasm	Coiled coil | DNA damage | DNA repair | DNA replication | Endonuclease | Exonuclease | Hydrolase | Magnesium | Metal-binding | Mitochondrion | Nuclease | Nucleus | Phosphoprotein | Reference proteome		Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA
Haemaphysalis longicornis	44386	A0A9J6FGD8	Dual specificity protein phosphatase		204	Unreviewed		negative regulation of MAPK cascade	MAP kinase phosphatase activity | protein serine/threonine phosphatase activity | protein tyrosine phosphatase activity | protein tyrosine/serine/threonine phosphatase activity	cytoplasm	Hydrolase | Protein phosphatase | Reference proteome		Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate
Haemaphysalis longicornis	44386	A0A9J6FGD1	protein-tyrosine-phosphatase		473	Unreviewed	Endomembrane system | Endoplasmic reticulum	negative regulation of ERK1 and ERK2 cascade | negative regulation of receptor signaling pathway via JAK-STAT | neuron development	non-membrane spanning protein tyrosine phosphatase activity | protein kinase binding	endoplasmic reticulum | nucleus	Endoplasmic reticulum | Hydrolase | Membrane | Phosphoprotein | Protein phosphatase | Reference proteome | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6FG61	dTCF		456	Unreviewed	Nucleus	canonical Wnt signaling pathway | mesodermal cell fate determination | negative regulation of DNA-templated transcription | positive regulation of gene expression | regulation of stem cell proliferation | salivary gland morphogenesis | spiracle morphogenesis, open tracheal system	DNA-binding transcription factor activity, RNA polymerase II-specific | kinase binding | RNA polymerase II cis-regulatory region sequence-specific DNA binding | transcription corepressor binding	beta-catenin-TCF complex | chromatin	Activator | DNA-binding | Nucleus | Reference proteome | Transcription | Transcription regulation | Wnt signaling pathway		Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes
Haemaphysalis longicornis	44386	A0A9J6FG25	Stress-activated protein kinase JNK		415	Unreviewed	Cytoplasm	regulation of response to wounding	ATP binding | MAP kinase activity | protein serine kinase activity	cytoplasm | somatodendritic compartment	ATP-binding | Kinase | Magnesium | Nucleotide-binding | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity
Haemaphysalis longicornis	44386	A0A9J6FG20	Serine/threonine-protein phosphatase		327	Unreviewed	Cell projection, pseudopodium	amoeboid sperm motility | egg-laying behavior | male meiosis chromosome segregation | regulation of pseudopodium assembly	metal ion binding | protein serine/threonine phosphatase activity	cytoplasm | nucleus | pseudopodium	Hydrolase | Manganese | Metal-binding | Protein phosphatase | Reference proteome		Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium
Haemaphysalis longicornis	44386	A0A9J6FFZ4	Pre-mRNA-processing factor 19		488	Unreviewed	Nucleus, nucleoplasm	DNA repair | mRNA splicing, via spliceosome | protein K63-linked ubiquitination	ubiquitin protein ligase activity	cytoplasm | nucleoplasm | Prp19 complex | U2-type catalytic step 1 spliceosome	DNA damage | DNA repair | mRNA processing | mRNA splicing | Nucleus | Reference proteome | Repeat | Spliceosome | Transferase | Ubl conjugation pathway | WD repeat		Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome
Haemaphysalis longicornis	44386	A0A9J6FM47	DNA replication licensing factor MCM2		739	Unreviewed	Chromosome | Nucleus	double-strand break repair via break-induced replication | mitotic DNA replication initiation	3'-5' DNA helicase activity | ATP binding | hydrolase activity | single-stranded DNA binding | single-stranded DNA helicase activity | zinc ion binding	MCM complex | nuclear chromosome	ATP-binding | Cell cycle | Chromosome | DNA replication | DNA-binding | Helicase | Hydrolase | Metal-binding | Nucleotide-binding | Nucleus | Reference proteome | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6FFI0	SNF-related serine/threonine-protein kinase		319	Unreviewed	Nucleus	intracellular signal transduction	ATP binding | metal ion binding | protein serine/threonine kinase activity	cytoplasm | nucleus	ATP-binding | Kinase | Magnesium | Metal-binding | Methylation | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis
Haemaphysalis longicornis	44386	A0A9J6FFC9	Histone acetyltransferase		395	Unreviewed	Nucleus	regulation of DNA-templated transcription	histone H4K16 acetyltransferase activity | zinc ion binding	MSL complex | NSL complex | NuA4 histone acetyltransferase complex | nucleus	Acetylation | Membrane | Metal-binding | Nucleus | Reference proteome | Transcription | Transcription regulation | Transferase | Transmembrane | Transmembrane helix | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6FH59	protein xylosyltransferase		1319	Unreviewed	Cell membrane | Endoplasmic reticulum membrane | Golgi apparatus membrane	chondroitin sulfate proteoglycan biosynthetic process | heparan sulfate proteoglycan biosynthetic process	chloride channel activity | metal ion binding | protein xylosyltransferase activity	chloride channel complex | endoplasmic reticulum membrane | Golgi membrane | plasma membrane	Cell membrane | Chloride | Chloride channel | Disulfide bond | Endoplasmic reticulum | Glycoprotein | Glycosyltransferase | Golgi apparatus | Ion channel | Ion transport | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix | Transport		
Haemaphysalis longicornis	44386	A0A9J6FF10	diphosphoinositol-polyphosphate diphosphatase		181	Unreviewed	Cytoplasm	adenosine 5'-(hexahydrogen pentaphosphate) catabolic process | diadenosine hexaphosphate catabolic process | diadenosine pentaphosphate catabolic process | diphosphoinositol polyphosphate metabolic process	bis(5'-adenosyl)-hexaphosphatase activity | bis(5'-adenosyl)-pentaphosphatase activity | diphosphoinositol-polyphosphate diphosphatase activity | endopolyphosphatase activity | metal ion binding	cytoplasm | nucleus	Cytoplasm | Hydrolase | Magnesium | Metal-binding | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6FE18	alpha-1,2-Mannosidase		590	Unreviewed	Endoplasmic reticulum membrane	carbohydrate metabolic process | proteasomal protein catabolic process | response to endoplasmic reticulum stress	calcium ion binding | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum membrane	Calcium | Disulfide bond | Endoplasmic reticulum | Glycosidase | Hydrolase | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transmembrane | Transmembrane helix		Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2)
Haemaphysalis longicornis	44386	A0A9J6FDS7	histone acetyltransferase		1009	Unreviewed	Nucleus	nucleosome assembly | regulation of transcription by RNA polymerase II	chromatin binding | DNA binding | histone H3 acetyltransferase activity | transcription coregulator activity | zinc ion binding	MOZ/MORF histone acetyltransferase complex | nucleosome | nucleus	Acetylation | Activator | Chromatin regulator | Isopeptide bond | Metal-binding | Nucleus | Phosphoprotein | Reference proteome | Repeat | Repressor | Transferase | Ubl conjugation | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6FDL0	Long-chain-fatty-acid--CoA ligase		747	Unreviewed			arachidonate-CoA ligase activity | ATP binding	endoplasmic reticulum | membrane	ATP-binding | Fatty acid metabolism | Ligase | Lipid metabolism | Membrane | Nucleotide-binding | Reference proteome | Transmembrane | Transmembrane helix		Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation
Haemaphysalis longicornis	44386	A0A9J6FDJ2	Histone deacetylase		415	Unreviewed	Chromosome | Cytoplasm | Nucleus	heterochromatin formation	histone deacetylase activity, hydrolytic mechanism | metal ion binding	chromosome | cytoplasm | nucleus	Chromatin regulator | Chromosome | Cytoplasm | Hydrolase | Metal-binding | Nucleus | Reference proteome | Repressor | Transcription | Transcription regulation		
Haemaphysalis longicornis	44386	A0A9J6FCC0	E3 ubiquitin-protein ligase parkin		472	Unreviewed	Cytoplasm, cytosol | Mitochondrion	mitophagy | negative regulation of intracellular signal transduction | positive regulation of catabolic process | protein ubiquitination | regulation of anatomical structure morphogenesis | response to stress	ubiquitin protein ligase activity | zinc ion binding	cytosol | mitochondrion | ubiquitin ligase complex	Autophagy | Cytoplasm | Metal-binding | Mitochondrion | Phosphoprotein | Reference proteome | Repeat | Signal | Transferase | Ubl conjugation | Ubl conjugation pathway | Zinc | Zinc-finger		Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins
Haemaphysalis longicornis	44386	A0A9J6FBT4	Mitochondrial 2-oxodicarboxylate carrier		330	Unreviewed	Mitochondrion inner membrane	transmembrane transport		mitochondrial inner membrane	Membrane | Mitochondrion | Mitochondrion inner membrane | Reference proteome | Repeat | Transmembrane | Transmembrane helix | Transport		Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle
Haemaphysalis longicornis	44386	A0A9J6FAU0	Valine--tRNA ligase		1109	Unreviewed	Cytoplasm | Mitochondrion	valyl-tRNA aminoacylation	aminoacyl-tRNA deacylase activity | ATP binding | valine-tRNA ligase activity	cytosol | mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Coiled coil | Cytoplasm | Ligase | Mitochondrion | Nucleotide-binding | Protein biosynthesis | Reference proteome | Transit peptide		Catalyzes the attachment of valine to tRNA(Val) in a two-step reaction: valine is first activated by ATP to form Val-AMP and then transferred to the acceptor end of tRNA(Val)
Haemaphysalis longicornis	44386	A0A9J6FAR7	Serine/threonine-protein kinase RIO1		579	Unreviewed	Cytoplasm	ribosome biogenesis	ATP binding | hydrolase activity | metal ion binding | protein serine/threonine kinase activity	cytoplasm	ATP-binding | Cytoplasm | Hydrolase | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Reference proteome | Ribosome biogenesis | Serine/threonine-protein kinase | Transferase		Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation
Haemaphysalis longicornis	44386	A0A9J6FAD1	N-terminal amino-acid N(alpha)-acetyltransferase NatA		330	Unreviewed			protein N-terminal-serine acetyltransferase activity | protein-N-terminal-glutamate acetyltransferase activity	NatA complex	Acyltransferase | Reference proteome | Transferase		
Haemaphysalis longicornis	44386	A0A9J6FAA6	Phosphoinositide phospholipase C		417	Unreviewed		lipid catabolic process | phosphatidylinositol metabolic process | phosphatidylinositol-mediated signaling | release of sequestered calcium ion into cytosol	lyase activity | metal ion binding | phosphatidylinositol-4,5-bisphosphate phospholipase C activity		Coiled coil | Disulfide bond | Hydrolase | Lipid degradation | Lipid metabolism | Lyase | Magnesium | Metal-binding | Reference proteome | Signal | Transducer		
Haemaphysalis longicornis	44386	A0A9J6F9S7	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial		334	Unreviewed	Mitochondrion	tricarboxylic acid cycle	nucleotide binding | succinate-CoA ligase (ADP-forming) activity | succinate-CoA ligase (GDP-forming) activity	mitochondrion | succinate-CoA ligase complex (ADP-forming)	Ligase | Mitochondrion | Nucleotide-binding | Reference proteome | Tricarboxylic acid cycle		Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits
Haemaphysalis longicornis	44386	A0A9J6F8E3	Dual specificity protein phosphatase 15		179	Unreviewed	Cell membrane	signal transduction	protein serine/threonine phosphatase activity | protein tyrosine phosphatase activity	cytosol | plasma membrane	Cell membrane | Hydrolase | Lipoprotein | Membrane | Myristate | Protein phosphatase | Reference proteome		
Haemaphysalis longicornis	44386	A0A9E8G7E3	Superoxide dismutase	SOD2	222	Unreviewed	Mitochondrion		manganese ion binding | protein homodimerization activity | superoxide dismutase activity	mitochondrion | respiratory chain complex	Manganese | Metal-binding | Mitochondrion | Oxidoreductase		Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Haemaphysalis longicornis	44386	A0A9J6FE30	Ion transport domain-containing protein		1226	Unreviewed	Membrane	calcium ion import across plasma membrane | calcium-mediated signaling | chemical synaptic transmission | detection of abiotic stimulus | detection of external stimulus | detection of stimulus involved in sensory perception | epithelial fluid transport | neuron remodeling	high voltage-gated calcium channel activity | metal ion binding	basolateral plasma membrane | synapse | voltage-gated calcium channel complex	Calcium | Calcium channel | Calcium transport | Coiled coil | Glycoprotein | Ion channel | Ion transport | Membrane | Metal-binding | Reference proteome | Repeat | Transmembrane | Transmembrane helix | Transport | Voltage-gated channel		
Haemaphysalis longicornis	44386	A0A9J6FHS7	GMP reductase		273	Unreviewed		purine nucleobase metabolic process | purine nucleotide metabolic process	GMP reductase activity | metal ion binding	GMP reductase complex	Metal-binding | NADP | Oxidoreductase | Potassium | Purine metabolism | Reference proteome		Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
Haemaphysalis longicornis	44386	A0A9J6FFT8	Vacuolar protein sorting-associated protein 35		750	Unreviewed	Cytoplasm | Early endosome | Late endosome | Membrane	neurotransmitter receptor transport, endosome to plasma membrane | positive regulation of gene expression | positive regulation of signal transduction | regulation of developmental process | regulation of postsynapse organization | regulation of protein catabolic process | regulation of protein localization | regulation of protein stability | regulation of transport | retrograde transport, endosome to Golgi	D1 dopamine receptor binding	cytosol | early endosome | late endosome | retromer, cargo-selective complex	Cytoplasm | Endosome | Membrane | Phosphoprotein | Protein transport | Reference proteome | Transport		Plays a role in vesicular protein sorting
Haemaphysalis longicornis	44386	A0A9J6FI37	Ubiquitin-conjugating enzyme E2 C		179	Unreviewed		cell division	ATP binding | ubiquitin conjugating enzyme activity		ATP-binding | Cell cycle | Cell division | Mitosis | Nucleotide-binding | Reference proteome | Transferase | Ubl conjugation | Ubl conjugation pathway		Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit
Haemaphysalis longicornis	44386	A0A9J6FLX4	Vesicular inhibitory amino acid transporter		398	Unreviewed	Cytoplasmic vesicle membrane | Presynapse	gamma-aminobutyric acid import | neurotransmitter transport	gamma-aminobutyric acid:proton antiporter activity | glycine transmembrane transporter activity | L-amino acid transmembrane transporter activity	cytoplasmic vesicle membrane | inhibitory synapse | presynapse | vacuolar membrane	Cell projection | Cytoplasmic vesicle | Membrane | Neurotransmitter transport | Reference proteome | Synapse | Transmembrane | Transmembrane helix | Transport		Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake
Haemaphysalis longicornis	44386	A0A9J6FI02	Protein kinase domain-containing protein		304	Unreviewed		G1/S transition of mitotic cell cycle | regulation of G2/M transition of mitotic cell cycle | signal transduction	ATP binding | cyclin binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	cyclin-dependent protein kinase holoenzyme complex | cytoplasm | nucleus	ATP-binding | Kinase | Nucleotide-binding | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6FLU0	Vesicle-associated membrane protein 7		213	Unreviewed	Cytoplasmic vesicle, phagosome membrane | Cytoplasmic vesicle, secretory vesicle membrane | Endoplasmic reticulum membrane | Golgi apparatus, trans-Golgi network membrane | Late endosome membrane | Lysosome membrane	exocytosis | protein transport | vesicle fusion	SNAP receptor activity | SNARE binding	endoplasmic reticulum membrane | Golgi apparatus | late endosome membrane | lysosomal membrane | phagocytic vesicle membrane | SNARE complex | transport vesicle membrane	Coiled coil | Membrane | Protein transport | Reference proteome | Transmembrane | Transmembrane helix | Transport		
Haemaphysalis longicornis	44386	A0A9J6FLL5	dynamin GTPase		652	Unreviewed	Cytoplasm, cytosol | Mitochondrion outer membrane	endocytosis | intracellular distribution of mitochondria | mitochondrial fission | peroxisome fission	GTP binding | GTPase activity | lipid binding | microtubule binding	cytosol | microtubule | mitochondrial outer membrane	Cytoplasm | GTP-binding | Hydrolase | Lipid-binding | Membrane | Mitochondrion | Mitochondrion outer membrane | Nucleotide-binding | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6FLI7	Laminin subunit beta-1		1415	Unreviewed	Secreted, extracellular space, extracellular matrix, basement membrane	animal organ morphogenesis | axon guidance | basement membrane assembly | cell migration | substrate adhesion-dependent cell spreading | tissue development		cytoplasm | laminin-1 complex | laminin-10 complex	Basement membrane | Cell adhesion | Coiled coil | Disulfide bond | Extracellular matrix | Glycoprotein | Laminin EGF-like domain | Reference proteome | Repeat | Secreted | Signal		
Haemaphysalis longicornis	44386	A0A9J6FLD6	Regulator of telomere elongation helicase 1 homolog		968	Unreviewed	Nucleus	DNA recombination | DNA repair | DNA replication | negative regulation of DNA recombination | negative regulation of t-circle formation | regulation of double-strand break repair via homologous recombination | telomeric loop disassembly	4 iron, 4 sulfur cluster binding | ATP binding | DNA binding | DNA helicase activity | DNA polymerase binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | metal ion binding	nucleus	4Fe-4S | ATP-binding | DNA damage | DNA repair | DNA-binding | Helicase | Hydrolase | Iron | Iron-sulfur | Isomerase | Metal-binding | Nucleotide-binding | Nucleus | Reference proteome		A probable ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates
Haemaphysalis longicornis	44386	A0A9J6FL59	Ubiquitin-conjugating enzyme E2 H		186	Unreviewed			ATP binding | ubiquitin conjugating enzyme activity		Acetylation | ATP-binding | Nucleotide-binding | Reference proteome | Signal | Transferase | Ubl conjugation | Ubl conjugation pathway		Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A
Haemaphysalis longicornis	44386	A0A9J6FKY9	Putative inositol monophosphatase 3		314	Unreviewed	Membrane	phosphatidylinositol phosphate biosynthetic process	3'-nucleotidase activity | inositol monophosphate phosphatase activity | metal ion binding	Golgi apparatus | membrane	Hydrolase | Magnesium | Membrane | Metal-binding | Reference proteome | Transmembrane | Transmembrane helix		
Haemaphysalis longicornis	44386	A0A9J6FKW2	E3 ubiquitin-protein ligase RNF144B		601	Unreviewed	Cytoplasm | Mitochondrion membrane	apoptotic process | protein ubiquitination	ubiquitin protein ligase activity | zinc ion binding	mitochondrial membrane	Apoptosis | Cytoplasm | Membrane | Metal-binding | Mitochondrion | Reference proteome | Repeat | Transferase | Transmembrane | Transmembrane helix | Ubl conjugation | Ubl conjugation pathway | Zinc | Zinc-finger		E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Plays a crucial role in maintaining the genomic stability by controlling the degradation of multiple proteins involved in mitotic progression and DNA damage. Regulates epithelial homeostasis by mediating degradation of CDKN1A and isoform 2 of TP63. Plays a regulatory role in innate immunity by negatively regulating IRF3 activation and IFN-beta production. Mechanistically, inhibits TBK1 phosphorylation and 'Lys-63'-linked polyubiquitination independently of its E3 ligase activity. Alternatively, promotes 'Lys-27' and 'Lys-33'-linked ubiquitination of IFIH1/MDA5, promoting selective autophagic degradation of IFIH1/MDA5 to inhibit antiviral response
Haemaphysalis longicornis	44386	A0A9J6FKP1	Serine/threonine-protein phosphatase		391	Unreviewed	Cell projection, pseudopodium	amoeboid sperm motility | egg-laying behavior | male meiosis chromosome segregation | regulation of pseudopodium assembly	metal ion binding | protein serine/threonine phosphatase activity	cytoplasm | nucleus | pseudopodium	Hydrolase | Manganese | Metal-binding | Protein phosphatase | Reference proteome		Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium
Haemaphysalis longicornis	44386	A0A9J6FKN9	ubiquitinyl hydrolase 1		515	Unreviewed		cell migration | cytoskeleton organization | positive regulation of Wnt signaling pathway | protein deubiquitination involved in ubiquitin-dependent protein catabolic process | protein K29-linked deubiquitination | protein K33-linked deubiquitination | Wnt signaling pathway	cysteine-type deubiquitinase activity | K63-linked polyubiquitin modification-dependent protein binding | zinc ion binding	cytoplasm | nucleus	Hydrolase | Metal-binding | Protease | Reference proteome | Thiol protease | Ubl conjugation pathway | Wnt signaling pathway | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6FKK4	Delta-1-pyrroline-5-carboxylate synthase		760	Unreviewed		L-proline biosynthetic process	ATP binding | glutamate 5-kinase activity | glutamate-5-semialdehyde dehydrogenase activity	mitochondrion	Amino-acid biosynthesis | ATP-binding | Kinase | Multifunctional enzyme | NADP | Nucleotide-binding | Oxidoreductase | Proline biosynthesis | Reference proteome | Transferase		
Haemaphysalis longicornis	44386	A0A9J6FKH9	10-formyltetrahydrofolate dehydrogenase		907	Unreviewed		10-formyltetrahydrofolate catabolic process | one-carbon metabolic process	formyltetrahydrofolate dehydrogenase activity | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	cytoplasm	NADP | One-carbon metabolism | Oxidoreductase | Phosphopantetheine | Phosphoprotein | Reference proteome		
Haemaphysalis longicornis	44386	A0A9J6FKF0	Aurora kinase		341	Unreviewed	Midbody	chromatin organization | chromosome condensation | cytokinetic process | mitotic sister chromatid segregation	ATP binding | protein serine/threonine kinase activity	midbody	ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6FLW8	Xaa-Pro aminopeptidase 1		1173	Unreviewed	Cytoplasm	proteolysis	metalloaminopeptidase activity | zinc ion binding	cytoplasm	Acetylation | Aminopeptidase | Cytoplasm | Hydrolase | Manganese | Metal-binding | Metalloprotease | Protease | Reference proteome | Zinc | Zinc-finger		Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Contributes to the degradation of bradykinin
Haemaphysalis longicornis	44386	A0A9J6FK29	Drebrin		464	Unreviewed	Cytoplasm, cytoskeleton	neuron projection morphogenesis | positive regulation of axon extension | postsynaptic actin cytoskeleton organization | regulation of actin filament polymerization	actin filament binding	actin filament | cortical actin cytoskeleton | dendrite | lamellipodium | postsynaptic density | postsynaptic membrane | site of polarized growth	Actin-binding | Coiled coil | Cytoplasm | Cytoskeleton | Reference proteome | SH3 domain		
Haemaphysalis longicornis	44386	A0A9J6FIC6	Carboxypeptidase Q		472	Unreviewed	Endoplasmic reticulum | Golgi apparatus | Lysosome | Secreted	peptide catabolic process | proteolysis	carboxypeptidase activity | metal ion binding | metallodipeptidase activity	endoplasmic reticulum | extracellular space | Golgi apparatus | lysosome	Carboxypeptidase | Endoplasmic reticulum | Glycoprotein | Golgi apparatus | Hydrolase | Lysosome | Metal-binding | Metalloprotease | Protease | Reference proteome | Secreted | Signal | Zinc | Zymogen		
Haemaphysalis longicornis	44386	A0A9J6FIQ1	Aurora kinase		295	Unreviewed	Midbody	chromatin organization | chromosome condensation | cytokinetic process | mitotic sister chromatid segregation	ATP binding | protein serine/threonine kinase activity	midbody	ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6FIU5	Serine/threonine-protein phosphatase		325	Unreviewed	Cell projection, pseudopodium	amoeboid sperm motility | egg-laying behavior | male meiosis chromosome segregation | regulation of pseudopodium assembly	metal ion binding | protein serine/threonine phosphatase activity	cytoplasm | nucleus | pseudopodium	Hydrolase | Manganese | Metal-binding | Protein phosphatase | Reference proteome		Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium
Haemaphysalis longicornis	44386	A0A9J6FKB4	non-specific serine/threonine protein kinase		1470	Unreviewed		DNA damage checkpoint signaling	ATP binding | eukaryotic translation initiation factor 2alpha kinase activity	cytoplasm | nucleus	ATP-binding | Coiled coil | Kinase | Nucleotide-binding | Reference proteome | Serine/threonine-protein kinase | Transferase		
Haemaphysalis longicornis	44386	A0A9J6FIX5	Serine/threonine-protein phosphatase		338	Unreviewed	Cell projection, pseudopodium	amoeboid sperm motility | egg-laying behavior | male meiosis chromosome segregation | regulation of pseudopodium assembly	metal ion binding | protein serine/threonine phosphatase activity	cytoplasm | nucleus | pseudopodium	Hydrolase | Manganese | Metal-binding | Protein phosphatase | Reference proteome		Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium
Haemaphysalis longicornis	44386	A0A9J6FJ79	E3 ubiquitin-protein ligase TRIM71		753	Unreviewed	Cytoplasm, P-body	negative regulation of translation | proteasome-mediated ubiquitin-dependent protein catabolic process | protein polyubiquitination | regulatory ncRNA-mediated gene silencing	miRNA binding | ubiquitin protein ligase activity | zinc ion binding	P-body	Coiled coil | Cytoplasm | Developmental protein | Metal-binding | Reference proteome | Repeat | RNA-binding | RNA-mediated gene silencing | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		
Haemaphysalis longicornis	44386	A0A9J6FIX0	Purine nucleoside phosphorylase		449	Unreviewed		nucleoside metabolic process	purine-nucleoside phosphorylase activity	cytoplasm	Coiled coil | Glycosyltransferase | Reference proteome | Transferase		
Haemaphysalis longicornis	44386	A0A9J6FJB9	NADPH-dependent diflavin oxidoreductase 1		581	Unreviewed	Cytoplasm	iron-sulfur cluster assembly	flavin adenine dinucleotide binding | FMN binding | NADP binding | NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity | oxidoreductase activity, acting on NAD(P)H	cytosol | nucleus	Cytoplasm | FAD | Flavoprotein | FMN | NADP | Oxidoreductase | Reference proteome		NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair. In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A
Haemaphysalis longicornis	44386	A0A9J6FJD6	Guanine nucleotide-binding protein G(O) subunit alpha		218	Unreviewed		adenylate cyclase-modulating G protein-coupled receptor signaling pathway | asymmetric cell division | axon ensheathment in central nervous system | calcium-mediated signaling | cortical actin cytoskeleton organization | establishment of glial blood-brain barrier | septate junction assembly | ventral cord development	G protein-coupled receptor binding | G-protein beta/gamma-subunit complex binding | GTP binding | GTPase activity | metal ion binding	cytoplasm | heterotrimeric G-protein complex	GTP-binding | Lipoprotein | Magnesium | Metal-binding | Myristate | Nucleotide-binding | Palmitate | Reference proteome | Transducer		
Haemaphysalis longicornis	44386	A0A9J6FJK4	Dihydropteridine reductase		192	Unreviewed		L-phenylalanine catabolic process | tetrahydrobiopterin biosynthetic process	6,7-dihydropteridine reductase activity | NADH binding | NADPH binding	cytoplasm	NADP | Oxidoreductase | Reference proteome | Tetrahydrobiopterin biosynthesis		Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin
Haemaphysalis longicornis	44386	A0A9J6FI49	Ubiquitin-conjugating enzyme E2 H		199	Unreviewed			ATP binding | ubiquitin conjugating enzyme activity		Acetylation | ATP-binding | Nucleotide-binding | Reference proteome | Transferase | Ubl conjugation | Ubl conjugation pathway		Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A
Haemaphysalis longicornis	44386	A0A9J6FJ97	ADP-ribosylhydrolase ARH3		355	Unreviewed	Chromosome | Cytoplasm | Mitochondrion matrix | Nucleus	DNA repair | peptidyl-serine ADP-deribosylation	metal ion binding | poly(ADP-ribose) glycohydrolase activity	chromosome | mitochondrial matrix | nucleus	Chromosome | Cytoplasm | DNA damage | DNA repair | Hydrolase | Magnesium | Metal-binding | Mitochondrion | Nucleus | Reference proteome		
Haemaphysalis montgomeryi	1429820	A0A8E5XPA5	F-ATPase protein 6	ATP6	221	Unreviewed	Membrane		proton-transporting ATP synthase activity, rotational mechanism	proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Haemaphysalis montgomeryi	1429820	A0A8E5XNW9	ATP synthase F0 subunit 8	ATP8	53	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Haemaphysalis montgomeryi	1429820	A0A8E5UXR0	NADH dehydrogenase subunit 6	ND6	144	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Haemaphysalis montgomeryi	1429820	A0A8E5XNN2	Cytochrome c oxidase subunit 2	COX2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Haemaphysalis montgomeryi	1429820	A0A8E5XN78	NADH-ubiquinone oxidoreductase chain 3	ND3	112	Unreviewed	Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Haemaphysalis montgomeryi	1429820	A0A8E5V0X5	NADH-ubiquinone oxidoreductase chain 4L	ND4L	91	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Haemaphysalis montgomeryi	1429820	A0A8E5XMA1	Cytochrome c oxidase subunit 3	COX3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		
Haemaphysalis montgomeryi	1429820	A0A8E5UYG7	NADH-ubiquinone oxidoreductase chain 2	ND2	319	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis montgomeryi	1429820	A0A8E5UX11	NADH-ubiquinone oxidoreductase chain 5	ND5	551	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis montgomeryi	1429820	A0A8E5UWT8	Cytochrome b	CYTB	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Haemaphysalis montgomeryi	1429820	A0A8E5UWS5	NADH-ubiquinone oxidoreductase chain 4	ND4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Haemaphysalis montgomeryi	1429820	A0A8E5UZA9	Cytochrome c oxidase subunit 1	COX1	512	Unreviewed	Membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrion | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		
Haemaphysalis montgomeryi	1429820	A0A8E5UZ68	NADH-ubiquinone oxidoreductase chain 1	ND1	315	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma aegyptium	72854	A0A7T3PLZ9	Cytochrome b	cytB	209	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma aegyptium	72854	A0A8E6Z6K8	NADH-ubiquinone oxidoreductase chain 3	ND3	111	Unreviewed	Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Hyalomma aegyptium	72854	A0A8E6Z6X9	NADH-ubiquinone oxidoreductase chain 4	ND4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma aegyptium	72854	A0A8E6Z7J6	NADH-ubiquinone oxidoreductase chain 5	ND5	552	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma aegyptium	72854	A0A8E7DL97	Cytochrome b	CYTB	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma aegyptium	72854	A0A8E7DLA7	NADH-ubiquinone oxidoreductase chain 1	ND1	313	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma aegyptium	72854	A0A8E7DLU0	Cytochrome c oxidase subunit 3	COIII	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	A0A2S1N527	Cytochrome b		213	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma aegyptium	72854	A0A8E7DP27	Cytochrome c oxidase subunit 2	COII	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	A0A8E6Z622	NADH dehydrogenase subunit 4L	ND4L	91	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Hyalomma aegyptium	72854	A0A8E6Z827	F-ATPase protein 6	ATP6	221	Unreviewed	Membrane		proton-transporting ATP synthase activity, rotational mechanism	proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Hyalomma aegyptium	72854	A0A8E6Z8C5	NADH dehydrogenase subunit 6	ND6	144	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Hyalomma aegyptium	72854	A0A8E6Z996	ATP synthase subunit 8	ATP8	54	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Hyalomma aegyptium	72854	Q8HKC4	NADH dehydrogenase subunit 1	ND1	38	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Hyalomma aegyptium	72854	A0A8E7DN06	NADH-ubiquinone oxidoreductase chain 2	ND2	320	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma aegyptium	72854	A0A2S1N520	Cytochrome b		214	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma aegyptium	72854	A0A891IS31	Cytochrome c oxidase subunit 1	COX1	181	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	A0A240EVQ5	Histone H3	H3	89	Unreviewed			DNA binding | protein heterodimerization activity | structural constituent of chromatin	nucleosome	Chromosome | DNA-binding | Nucleosome core | Nucleus		
Hyalomma aegyptium	72854	A0A2S1N507	Cytochrome b		214	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma aegyptium	72854	A0A0U2DGB4	Cytochrome c oxidase subunit 1	COI	153	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	A0A240EVI0	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	A0A6G9DSW0	Cytochrome c oxidase subunit 1	COX1	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	A0A8E6Z6B7	Cytochrome c oxidase subunit 1	COI	512	Unreviewed	Membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrion | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		
Hyalomma aegyptium	72854	K0A091	Cytochrome c oxidase subunit 1	COI	205	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	K0A1Z3	Cytochrome c oxidase subunit 1	COI	247	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	A0A240EVH8	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	A0A0U3DKD5	Cytochrome c oxidase subunit 1		241	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	Q9MD09	Cytochrome c oxidase subunit 1	COI	264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	A0A219YLZ5	Cytochrome c oxidase subunit 1		274	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	A0A240EVQ3	Histone H3	H3	89	Unreviewed			DNA binding | protein heterodimerization activity | structural constituent of chromatin	nucleosome	Chromosome | DNA-binding | Nucleosome core | Nucleus		
Hyalomma aegyptium	72854	A0A0U3DYH9	Cytochrome c oxidase subunit 1		239	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	A0A0U3DLK1	Cytochrome c oxidase subunit 1		238	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma aegyptium	72854	A0A219YLZ4	Cytochrome c oxidase subunit 1		264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A0U2SNR8	Subolesin		163	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	A0A0Y0ATS3	Tropomyosin		284	Unreviewed					Coiled coil		
Hyalomma anatolicum	176092	A0A0Y0ARL4	Tropomyosin		284	Unreviewed					Coiled coil		
Hyalomma anatolicum	176092	A0A0X9PWP3	Aspartic proteinase		199	Unreviewed		proteolysis	aspartic-type endopeptidase activity	lysosome	Aspartyl protease | Disulfide bond | Glycoprotein | Hydrolase | Protease | Signal | Zymogen		
Hyalomma anatolicum	176092	A0A0X9PRU7	Elongation factor 1 alpha	EF-1 alpha	121	Unreviewed			GTP binding | translation elongation factor activity		Elongation factor | Protein biosynthesis		
Hyalomma anatolicum	176092	A0A0X9PMU2	Subolesin-like protein		172	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	A0A0U2URL3	Subolesin		163	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	A0A0U2TZZ5	Subolesin		163	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	A0A0U2T382	Subolesin		163	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	A0A0U2T040	Subolesin		163	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	A0A0U2LZ49	Subolesin		163	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	U5KRM3	Cytochrome c oxidase subunit 1		219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A0U2K641	Subolesin		163	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	A0A0U2ID78	Subolesin		163	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	A0A0K1YW32	Sodium channel protein	Kdr	80	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Hyalomma anatolicum	176092	W8RGR6	Cytochrome c oxidase subunit 1		274	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	W8RD95	Cytochrome c oxidase subunit 1		272	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	U5KRP8	Cytochrome c oxidase subunit 1		209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A0Y0AUT9	Tropomyosin		284	Unreviewed					Coiled coil		
Hyalomma anatolicum	176092	A0A8E7DLC5	NADH-ubiquinone oxidoreductase chain 3	ND3	113	Unreviewed	Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Hyalomma anatolicum	176092	A0A8E6Z9C4	Cytochrome b	CYTB	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma anatolicum	176092	A0A8E6Z8E7	NADH-ubiquinone oxidoreductase chain 5	ND5	552	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma anatolicum	176092	A0A0U2L412	Subolesin		163	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	A0A0Y0AXB2	Tropomyosin		284	Unreviewed					Coiled coil		
Hyalomma anatolicum	176092	A0A6B9PGR9	Carboxylesterase		88	Unreviewed							
Hyalomma anatolicum	176092	A0A0Y0AXK6	Tropomyosin		284	Unreviewed					Coiled coil		
Hyalomma anatolicum	176092	S4UAH3	Subolesin		163	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	J7K9Q0	Subolesin-like protein		158	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	J7K9P7	Subolesin-like protein		158	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	J7K8Z4	Subolesin-like protein		158	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	J7K8Y7	Subolesin-like protein		158	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	J7K706	Subolesin-like protein		158	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	J7K3S8	Subolesin-like protein		158	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Hyalomma anatolicum	176092	J7IFH5	Acetylcholinesterase 2		133	Unreviewed			acetylcholinesterase activity		Glycoprotein | Hydrolase		
Hyalomma anatolicum	176092	J7ICT9	Acetylcholinesterase 2		133	Unreviewed			acetylcholinesterase activity		Glycoprotein | Hydrolase		
Hyalomma anatolicum	176092	J7I977	Acetylcholinesterase 2		133	Unreviewed			acetylcholinesterase activity		Glycoprotein | Hydrolase		
Hyalomma anatolicum	176092	E1B2N8	Carboxyl esterase		124	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Glycoprotein | Hydrolase | Serine esterase		
Hyalomma anatolicum	176092	A0A0Y0AXF8	Tropomyosin		284	Unreviewed					Coiled coil		
Hyalomma anatolicum	176092	A0A8X8RFT7	Voraxin alpha		153	Unreviewed							
Hyalomma anatolicum	176092	A0A8E7DLV4	ATP synthase subunit 8	ATP8	53	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Hyalomma anatolicum	176092	A0A8E7DLB6	NADH dehydrogenase subunit 6	ND6	143	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Hyalomma anatolicum	176092	A0A8E6Z709	F-ATPase protein 6	ATP6	221	Unreviewed	Membrane		proton-transporting ATP synthase activity, rotational mechanism	proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Hyalomma anatolicum	176092	A0A6B9PQV1	Carboxylesterase		90	Unreviewed							
Hyalomma anatolicum	176092	A0A6B9PN75	Sodium channel		43	Unreviewed	Membrane		monoatomic ion channel activity	membrane	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Hyalomma anatolicum	176092	A0A8E6Z7P3	NADH-ubiquinone oxidoreductase chain 1	ND1	313	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma anatolicum	176092	A0A6B9PCD6	Sodium channel		51	Unreviewed	Membrane		monoatomic ion channel activity	membrane	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Hyalomma anatolicum	176092	A0A3R5X4G5	Tams1	Tams1	190	Unreviewed							
Hyalomma anatolicum	176092	A0A3R5T0S6	Tams1	Tams1	191	Unreviewed							
Hyalomma anatolicum	176092	A0A109QJN6	Tropomyosin		284	Unreviewed					Coiled coil		
Hyalomma anatolicum	176092	A0A0Y0C614	Tropomyosin		284	Unreviewed					Coiled coil		
Hyalomma anatolicum	176092	A0A8E7DN24	NADH dehydrogenase subunit 4L	ND4L	91	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Hyalomma anatolicum	176092	A0A8E6Z7M3	Cytochrome c oxidase subunit 3	COIII	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A172WBZ9	Ferritin		154	Unreviewed		intracellular iron ion homeostasis | iron ion transport	ferric iron binding | ferrous iron binding | ferroxidase activity	cytoplasm	Iron | Iron storage | Metal-binding | Oxidoreductase		Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation
Hyalomma anatolicum	176092	A0A8E6Z645	NADH-ubiquinone oxidoreductase chain 4	ND4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma anatolicum	176092	A0A6M5E4T5	Cytochrome c oxidase subunit 1	CO1	124	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A8E6Z6E7	Cytochrome c oxidase subunit 2	COII	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A6M5E3F8	Cytochrome c oxidase subunit 1	CO1	105	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A6M5E0G5	Cytochrome c oxidase subunit 1	CO1	125	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A6G9DTB2	Cytochrome c oxidase subunit 1	COX1	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A6C0RMG6	Cytochrome c oxidase subunit 1	COI	235	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A5P1J0Y4	Cytochrome c oxidase subunit 1	cox1	216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A5P1J0X8	Cytochrome c oxidase subunit 1	cox1	216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A4D6G1H3	Cytochrome c oxidase subunit 1		122	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A4D6G1G5	Cytochrome c oxidase subunit 1		240	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A411PAS5	Cytochrome c oxidase subunit 1	COI	264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A411N1G6	Cytochrome c oxidase subunit 1	COI	144	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A346JEM7	Cytochrome c oxidase subunit 1	cox1	115	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A346JEM6	Cytochrome c oxidase subunit 1	cox1	115	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A345S534	Cytochrome c oxidase subunit 1	CO1	216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A2U8ZU24	Cytochrome c oxidase subunit 1	COI	201	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A240EVI4	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A0U2DBZ2	Cytochrome c oxidase subunit 1	COI	153	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A0U2DBX4	Cytochrome c oxidase subunit 1	COI	153	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A0A0RAM5	Cytochrome c oxidase subunit 1	COI	207	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A0A0RAM3	Cytochrome c oxidase subunit 1	COI	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A0A0R8I5	Cytochrome c oxidase subunit 1	COI	210	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A0A0R5G7	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A6M5E4U0	Cytochrome c oxidase subunit 1	CO1	104	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A6M5EAU2	Cytochrome c oxidase subunit 1	CO1	123	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A6M5E4P6	Cytochrome c oxidase subunit 1	CO1	126	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A873A9L6	Cytochrome c oxidase subunit 1	COX1	207	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A8E6Z644	NADH-ubiquinone oxidoreductase chain 2	ND2	320	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma anatolicum	176092	A0A7T3PLZ4	Cytochrome b	cytB	209	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma anatolicum	176092	A0A240EVR0	Histone H3	H3	89	Unreviewed			DNA binding | protein heterodimerization activity | structural constituent of chromatin	nucleosome	Chromosome | DNA-binding | Nucleosome core | Nucleus		
Hyalomma anatolicum	176092	A0A0X9R1S0	legumain		241	Unreviewed		proteolysis involved in protein catabolic process | vacuolar protein processing	cysteine-type endopeptidase activity	vacuole	Hydrolase | Protease | Signal | Thiol protease		
Hyalomma anatolicum	176092	A0A0X9P9U7	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	GAPDH	220	Unreviewed		glycolytic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | NAD binding	cytosol	Glycolysis | NAD | Oxidoreductase		
Hyalomma anatolicum	176092	A0A0S1EUX7	Ferritin		190	Unreviewed		intracellular iron ion homeostasis | iron ion transport	ferric iron binding | ferrous iron binding | ferroxidase activity	cytoplasm	Iron | Iron storage | Metal-binding | Oxidoreductase | Signal		Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation
Hyalomma anatolicum	176092	A0A0S1EU32	Ferritin		190	Unreviewed		intracellular iron ion homeostasis | iron ion transport	ferric iron binding | ferrous iron binding | ferroxidase activity	cytoplasm	Iron | Iron storage | Metal-binding | Oxidoreductase | Signal		Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation
Hyalomma anatolicum	176092	A0A0S1EU22	Ferritin		190	Unreviewed		intracellular iron ion homeostasis | iron ion transport	ferric iron binding | ferrous iron binding | ferroxidase activity	cytoplasm	Iron | Iron storage | Metal-binding | Oxidoreductase | Signal		Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation
Hyalomma anatolicum	176092	A0A7G6E952	Cytochrome c oxidase subunit 1	COX1	220	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A0N6VM44	Muscle LIM protein	MLP	106	Unreviewed	Nucleus	muscle organ development | muscle tissue development | sarcomere organization	actinin binding | metal ion binding | structural constituent of muscle	nucleus | Z disc	LIM domain | Metal-binding | Myogenesis | Nucleus | Repeat | Zinc		
Hyalomma anatolicum	176092	A0A8F2JLA4	Cytochrome c oxidase subunit 1	COX1	135	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A0S1ETX5	Ferritin		190	Unreviewed		intracellular iron ion homeostasis | iron ion transport	ferric iron binding | ferrous iron binding | ferroxidase activity	cytoplasm	Iron | Iron storage | Metal-binding | Oxidoreductase | Signal		Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation
Hyalomma anatolicum	176092	A0A8F2FLJ8	Cytochrome c oxidase subunit 1	COX1	133	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A873A9R7	Cytochrome c oxidase subunit 1	COX1	221	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A8F2FM62	Cytochrome c oxidase subunit 1	COX1	131	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A891ITS3	Cytochrome c oxidase subunit 1	COX1	181	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A8E4LH53	Cytochrome c oxidase subunit 1	COX1	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A8E6Z6M9	Cytochrome c oxidase subunit 1	COI	512	Unreviewed	Membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrion | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		
Hyalomma anatolicum	176092	A0A891IT18	Cytochrome c oxidase subunit 1	COX1	181	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A8F1A8Z9	Cytochrome c oxidase subunit 1	COX1	118	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A8F2FL79	Cytochrome c oxidase subunit 1	COX1	129	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A8F2FLA3	Cytochrome c oxidase subunit 1	COX1	130	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A8F2FLE5	Cytochrome c oxidase subunit 1	COX1	130	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma anatolicum	176092	A0A8F1A7R3	Cytochrome c oxidase subunit 1	COX1	75	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma detritum	572043	A0A7T3PM00	Cytochrome b	cytB	209	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma detritum	572043	G0Z2I4	Bm86-like protein		622	Unreviewed							
Hyalomma detritum	572043	G0Z2I2	Bm86-like protein		612	Unreviewed							
Hyalomma detritum	572043	W8RGS1	Cytochrome c oxidase subunit 1		273	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma detritum	572043	U5KRV6	Cytochrome c oxidase subunit 1		218	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma detritum	572043	U5KRE9	Cytochrome c oxidase subunit 1		219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma detritum	572043	A0A144L7I0	Cytochrome c oxidase subunit 1		235	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma detritum	572043	W8RZZ0	Cytochrome c oxidase subunit 1		272	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma detritum	572043	C6F0C2	Cytochrome c oxidase subunit 1	COI	286	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma detritum	572043	A0A8K1KV23	Cytochrome c oxidase subunit 1	COX1	268	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma detritum	572043	A0A897TB43	Cytochrome c oxidase subunit 1	COI	242	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma detritum	572043	A0A7G9XUK0	Cytochrome c oxidase subunit 1	COX1	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma detritum	572043	A0A6M5E2N2	Cytochrome c oxidase subunit 1	CO1	124	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma detritum	572043	V5J263	Cytochrome c oxidase subunit 1	COI	235	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma detritum	572043	A0A6G9DSQ9	Cytochrome c oxidase subunit 1	COX1	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma detritum	572043	A0A0U2DGC9	Cytochrome c oxidase subunit 1	COI	153	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	G9F7X2	Calreticulin		413	Unreviewed	Endoplasmic reticulum lumen	ERAD pathway | protein folding	calcium ion binding | carbohydrate binding | unfolded protein binding	endoplasmic reticulum lumen | endoplasmic reticulum membrane	Calcium | Chaperone | Disulfide bond | Endoplasmic reticulum | Lectin | Metal-binding | Repeat | Signal | Zinc		Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER
Hyalomma dromedarii	34626	Q8HAW3	Cytochrome c oxidase subunit 1	COI	264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	Q9MD08	Cytochrome c oxidase subunit 1	COI	264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	V5J223	Cytochrome c oxidase subunit 1	COI	235	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	X2EZM9	Cytochrome c oxidase subunit 1	COI	168	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A0U3EEF5	Cytochrome c oxidase subunit 1		210	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A0U3CAB6	Cytochrome c oxidase subunit 1		240	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A0U3CDU9	Cytochrome c oxidase subunit 1		239	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8K1KW47	Cytochrome c oxidase subunit 1	COX1	264	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A144L7J2	Cytochrome c oxidase subunit 1		235	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A0U2L0D8	Cytochrome c oxidase subunit 1		240	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U842	Cytochrome c oxidase subunit 1	COX1	197	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U7S7	Cytochrome c oxidase subunit 1	COX1	193	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U800	Cytochrome c oxidase subunit 1	COX1	202	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U7W9	Cytochrome c oxidase subunit 1	COX1	205	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A219XBR4	Histone H3	H3	89	Unreviewed			DNA binding | protein heterodimerization activity | structural constituent of chromatin	nucleosome	Chromosome | DNA-binding | Nucleosome core | Nucleus		
Hyalomma dromedarii	34626	A0A8E8U7P7	Cytochrome c oxidase subunit 1	COX1	200	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U7M4	Cytochrome c oxidase subunit 1	COX1	208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U7K9	Cytochrome c oxidase subunit 1	COX1	205	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U7K6	Cytochrome c oxidase subunit 1	COX1	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U7K0	Cytochrome c oxidase subunit 1	COX1	198	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U7I3	Cytochrome c oxidase subunit 1	COX1	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U7H1	Cytochrome c oxidase subunit 1	COX1	200	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PKG7	Cytochrome c oxidase subunit 1	COX1	205	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U833	Cytochrome c oxidase subunit 1	COX1	206	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A219YM15	Cytochrome c oxidase subunit 1		263	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A2S1N569	Cytochrome b		202	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma dromedarii	34626	A0A2S1N544	Cytochrome b		141	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma dromedarii	34626	Q7M3L2	Tick embryo basic protein		42	Unreviewed					Direct protein sequencing		
Hyalomma dromedarii	34626	G4WSC3	Bm86-like protein		626	Unreviewed							
Hyalomma dromedarii	34626	D7REL1	Salivary gland protein P18		153	Unreviewed					Signal		
Hyalomma dromedarii	34626	A0A8E4MHR4	Dromedarisin	drn	74	Unreviewed	Secreted	defense response to bacterium		extracellular region	Antibiotic | Antimicrobial | Disulfide bond | Secreted		
Hyalomma dromedarii	34626	A0A172SP58	Translationally-controlled tumor protein homolog		173	Unreviewed			calcium ion binding	cytoplasm			
Hyalomma dromedarii	34626	C9EBA1	Cytochrome c oxidase subunit 1		264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U810	Cytochrome c oxidase subunit 1	COX1	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U7Y9	Cytochrome c oxidase subunit 1	COX1	200	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8U7H7	Cytochrome c oxidase subunit 1	COX1	208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PKG4	Cytochrome c oxidase subunit 1	COX1	196	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PKC3	Cytochrome c oxidase subunit 1	COX1	206	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PKB3	Cytochrome c oxidase subunit 1	COX1	197	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PKA0	Cytochrome c oxidase subunit 1	COX1	195	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK71	Cytochrome c oxidase subunit 1	COX1	202	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK62	Cytochrome c oxidase subunit 1	COX1	201	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK57	Cytochrome c oxidase subunit 1	COX1	200	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6C0RJ11	Cytochrome c oxidase subunit 1		144	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6C0RHD8	Cytochrome c oxidase subunit 1		145	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6B9LUY7	Cytochrome c oxidase subunit 1		209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A3G1ZJ05	Small heat shock protein	sHSP	163	Unreviewed		protein refolding | response to heat	unfolded protein binding	cytoplasm | nucleus	Stress response		
Hyalomma dromedarii	34626	A0A346TLK6	Cytochrome c oxidase subunit 1		208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A346TLK5	Cytochrome c oxidase subunit 1		208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A2S1N573	Cytochrome b		202	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma dromedarii	34626	A0A8E8PKG1	Cytochrome c oxidase subunit 1	COX1	205	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A2S1N560	Cytochrome b		203	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma dromedarii	34626	A0A2S1N529	Cytochrome b		211	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma dromedarii	34626	A0A8E8PKF7	Cytochrome c oxidase subunit 1	COX1	206	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PKE2	Cytochrome c oxidase subunit 1	COX1	201	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A7D0IPY6	Cytochrome c oxidase subunit 1	COI	244	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6M3FYS2	Cytochrome c oxidase subunit 1	COX1	252	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6M3FYA7	Cytochrome c oxidase subunit 1	COX1	240	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6M3FXE0	Cytochrome c oxidase subunit 1	COX1	252	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6M3FX75	Cytochrome c oxidase subunit 1	COX1	241	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6M3FX30	Cytochrome c oxidase subunit 1	COX1	252	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6M3FX29	Cytochrome c oxidase subunit 1	COX1	256	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6M3FX22	Cytochrome c oxidase subunit 1	COX1	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6M3FX21	Cytochrome c oxidase subunit 1	COX1	250	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6M3EVX5	Cytochrome c oxidase subunit 1	COX1	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6M3EVR0	Cytochrome c oxidase subunit 1	COX1	241	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6M3EUN1	Cytochrome c oxidase subunit 1	COX1	231	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PKF4	Cytochrome c oxidase subunit 1	COX1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A6G6A1C2	Cytochrome c oxidase subunit 1	COX1	253	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A5B8WCB0	Cytochrome c oxidase subunit 1	COI	94	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A482K1C8	Cytochrome c oxidase subunit 1	COI	223	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A482K0B0	Cytochrome c oxidase subunit 1	COI	223	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A2U8ZUC6	Cytochrome c oxidase subunit 1	COI	201	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A2U8ZTZ9	Cytochrome c oxidase subunit 1	COI	201	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A240EVJ3	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A182BTD4	Cytochrome c oxidase subunit 1	CO1	257	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A0U2DBS6	Cytochrome c oxidase subunit 1	COI	153	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A0A0RAU1	Cytochrome c oxidase subunit 1	COI	210	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A0A0R8I3	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A0A0R892	Cytochrome c oxidase subunit 1	COI	210	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A5B8WDJ7	Cytochrome c oxidase subunit 1	COI	94	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A7D0IU08	Cytochrome c oxidase subunit 1	COI	244	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A7D0ISF6	Cytochrome c oxidase subunit 1	COI	244	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK80	Cytochrome c oxidase subunit 1	COX1	200	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PKB6	Cytochrome c oxidase subunit 1	COX1	201	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PKB2	Cytochrome c oxidase subunit 1	COX1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PKA7	Cytochrome c oxidase subunit 1	COX1	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PKA4	Cytochrome c oxidase subunit 1	COX1	205	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK96	Cytochrome c oxidase subunit 1	COX1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK93	Cytochrome c oxidase subunit 1	COX1	194	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK87	Cytochrome c oxidase subunit 1	COX1	196	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK85	Cytochrome c oxidase subunit 1	COX1	207	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK81	Cytochrome c oxidase subunit 1	COX1	196	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A7D0IWQ9	Cytochrome c oxidase subunit 1	COI	244	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK70	Cytochrome c oxidase subunit 1	COX1	206	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK67	Cytochrome c oxidase subunit 1	COX1	197	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK65	Cytochrome c oxidase subunit 1	COX1	194	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK37	Cytochrome c oxidase subunit 1	COX1	205	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK30	Cytochrome c oxidase subunit 1	COX1	202	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK23	Cytochrome c oxidase subunit 1	COX1	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK22	Cytochrome c oxidase subunit 1	COX1	201	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK21	Cytochrome c oxidase subunit 1	COX1	197	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK19	Cytochrome c oxidase subunit 1	COX1	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PK18	Cytochrome c oxidase subunit 1	COX1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E4JYB5	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A7D0N1X7	Cytochrome c oxidase subunit 1	COI	244	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A7D0MX37	Cytochrome c oxidase subunit 1	COI	244	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PKC0	Cytochrome c oxidase subunit 1	COX1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma dromedarii	34626	A0A8E8PKD6	Cytochrome c oxidase subunit 1	COX1	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma hussaini	139400	A0A891IQC8	Cytochrome c oxidase subunit 1	COX1	181	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma hussaini	139400	A0A891IPF7	Cytochrome c oxidase subunit 1	COX1	181	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma hussaini	139400	A0A219XBS4	Histone H3	H3	89	Unreviewed			DNA binding | protein heterodimerization activity | structural constituent of chromatin	nucleosome	Chromosome | DNA-binding | Nucleosome core | Nucleus		
Hyalomma kumari	1917744	A0A891IQ92	Cytochrome c oxidase subunit 1	COX1	181	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma kumari	1917744	A0A240EVT5	Histone H3	H3	89	Unreviewed			DNA binding | protein heterodimerization activity | structural constituent of chromatin	nucleosome	Chromosome | DNA-binding | Nucleosome core | Nucleus		
Hyalomma kumari	1917744	A0A219XBT7	Histone H3	H3	89	Unreviewed			DNA binding | protein heterodimerization activity | structural constituent of chromatin	nucleosome	Chromosome | DNA-binding | Nucleosome core | Nucleus		
Hyalomma kumari	1917744	A0A891IQB8	Cytochrome c oxidase subunit 1	COX1	181	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma kumari	1917744	A0A891IPE7	Cytochrome c oxidase subunit 1	COX1	181	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma kumari	1917744	A0A240EVL0	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A8S4C515	Glutamine--fructose-6-phosphate aminotransferase [isomerizing]		588	Unreviewed		amino sugar biosynthetic process | fructose 6-phosphate metabolic process | protein N-linked glycosylation | UDP-N-acetylglucosamine metabolic process	carbohydrate derivative binding | glutamine-fructose-6-phosphate transaminase (isomerizing) activity	cytosol	Aminotransferase | Glutamine amidotransferase | Reference proteome | Repeat | Transferase		
Hyalomma marginatum	34627	A0A8S4C519	7-cyano-7-deazaguanine synthase		226	Unreviewed			ATP binding | ligase activity | metal ion binding		ATP-binding | Ligase | Metal-binding | Nucleotide-binding | Reference proteome | Zinc		
Hyalomma marginatum	34627	A0A8S4C522	Methylated-DNA--protein-cysteine methyltransferase		190	Unreviewed		DNA repair | methylation	methylated-DNA-[protein]-cysteine S-methyltransferase activity		DNA damage | DNA repair | Methyltransferase | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C550	Dihydrolipoyl dehydrogenase		468	Unreviewed	Cytoplasm	2-oxoglutarate metabolic process	dihydrolipoyl dehydrogenase (NADH) activity | flavin adenine dinucleotide binding	cytoplasm	Cytoplasm | Disulfide bond | FAD | Flavoprotein | NAD | Nucleotide-binding | Oxidoreductase | Redox-active center | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C559	Propionyl-CoA carboxylase beta chain, mitochondrial		511	Unreviewed		fatty acid catabolic process	propionyl-CoA carboxylase activity	mitochondrion	Reference proteome		
Hyalomma marginatum	34627	A0A8S4C573	ATP synthase subunit alpha		507	Unreviewed	Membrane		ADP binding | ATP binding | proton-transporting ATP synthase activity, rotational mechanism	mitochondrion | proton-transporting ATP synthase complex	ATP synthesis | ATP-binding | Cell projection | CF(1) | Cilium | Flagellum | Hydrogen ion transport | Ion transport | Membrane | Nucleotide-binding | Reference proteome | Transport		Produces ATP from ADP in the presence of a proton gradient across the membrane
Hyalomma marginatum	34627	A0A8S4BUH7	Uncharacterized protein		36	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A889Q344	ATP synthase F0 subunit 8	ATP8	53	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A889ZCS3	NADH dehydrogenase subunit 6	ND6	143	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A889ZCT9	NADH dehydrogenase subunit 4L	ND4L	91	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BTB6	Flagellar hook capping protein flgD		261	Unreviewed					Cell projection | Cilium | Flagellum | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BTC5	RNA polymerase sigma factor RpoH		288	Unreviewed		DNA-templated transcription initiation	DNA binding | sigma factor activity		Cytoplasm | DNA-binding | Reference proteome | Sigma factor | Stress response | Transcription | Transcription regulation		
Hyalomma marginatum	34627	A0A8S4C508	NADH-quinone oxidoreductase subunit NuoI		162	Unreviewed		aerobic respiration	4 iron, 4 sulfur cluster binding | metal ion binding | NADH dehydrogenase activity	membrane | mitochondrion	4Fe-4S | Iron | Iron-sulfur | Metal-binding | Reference proteome | Translocase		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A889Q2Z4	NADH dehydrogenase subunit 6	ND6	143	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4C2A6	Single-stranded DNA-binding protein		154	Unreviewed	Mitochondrion	DNA replication	single-stranded DNA binding	mitochondrion | nucleoid	DNA-binding | Mitochondrion | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C4X3	Amino acid transporter		408	Unreviewed	Cell membrane | Membrane	dicarboxylic acid transport	symporter activity	plasma membrane	Cell membrane | Membrane | Reference proteome | Symport | Transmembrane | Transmembrane helix | Transport		
Hyalomma marginatum	34627	A0A8S4C4W8	NADH-ubiquinone oxidoreductase chain 5		643	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Reference proteome | Transmembrane | Transmembrane helix | Transport		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A8S4C4V6	Membrane protein insertase YidC		549	Unreviewed	Cell inner membrane	protein insertion into membrane | protein transport	membrane insertase activity	plasma membrane	Cell membrane | Chaperone | Membrane | Protein transport | Reference proteome | Transmembrane | Transmembrane helix | Transport		
Hyalomma marginatum	34627	A0A8S4C4U8	DNA polymerase III subunit alpha		1126	Unreviewed	Cytoplasm	DNA replication	3'-5' exonuclease activity | DNA-directed DNA polymerase activity | nucleic acid binding	cytoplasm	DNA replication | DNA-directed DNA polymerase | Nucleotidyltransferase | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C4U3	Probable transcriptional regulator ycf27		243	Unreviewed		regulation of DNA-templated transcription	phosphorelay response regulator activity | transcription cis-regulatory region binding	cytosol | protein-DNA complex	DNA-binding | Phosphoprotein | Reference proteome | Transcription | Transcription regulation | Two-component regulatory system		Probable promoter-specific protein mediating the interaction between DNA and RNA polymerase
Hyalomma marginatum	34627	A0A8S4C4T9	Cytochrome c1		254	Unreviewed	Membrane	mitochondrial electron transport, ubiquinol to cytochrome c	electron transfer activity | heme binding | metal ion binding	membrane | mitochondrion	Heme | Iron | Membrane | Metal-binding | Reference proteome | Signal | Transmembrane | Transmembrane helix		Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
Hyalomma marginatum	34627	A0A8S4C4T1	leucine--tRNA ligase		839	Unreviewed		leucyl-tRNA aminoacylation | mitochondrial translation	aminoacyl-tRNA deacylase activity | ATP binding | leucine-tRNA ligase activity	mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Cytoplasm | Ligase | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C4S4	Small ribosomal subunit protein bS6m		115	Unreviewed		translation	small ribosomal subunit rRNA binding | structural constituent of ribosome	cytoplasm | ribosome	Reference proteome | Ribonucleoprotein | Ribosomal protein		
Hyalomma marginatum	34627	A0A8S4C4S2	lipid-A-disaccharide synthase		398	Unreviewed		lipid A biosynthetic process	lipid-A-disaccharide synthase activity | phospholipid binding	membrane	Coiled coil | Glycosyltransferase | Lipid A biosynthesis | Lipid biosynthesis | Lipid metabolism | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C4R8	Cell shape-determining protein MreC		276	Unreviewed		regulation of cell shape		plasma membrane	Cell shape | Coiled coil | Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4C4Q8	L-lactate dehydrogenase		317	Unreviewed		lactate metabolic process	L-lactate dehydrogenase (NAD+) activity		NAD | Oxidoreductase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C4Q6	biotin synthase		310	Unreviewed		biotin biosynthetic process	2 iron, 2 sulfur cluster binding | 4 iron, 4 sulfur cluster binding | biotin synthase activity | metal ion binding		2Fe-2S | 4Fe-4S | Biotin biosynthesis | Iron | Iron-sulfur | Metal-binding | Reference proteome | S-adenosyl-L-methionine | Transferase		
Hyalomma marginatum	34627	A0A8S4C4N7	DNA translocase FtsK		747	Unreviewed	Cell membrane	cell division | chromosome segregation	ATP binding | DNA binding	plasma membrane	ATP-binding | Cell cycle | Cell division | Cell membrane | Chromosome partition | DNA-binding | Membrane | Nucleotide-binding | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4C4Y7	Replicative DNA helicase		478	Unreviewed		DNA replication, synthesis of primer	5'-3' DNA helicase activity | ATP binding | DNA binding | hydrolase activity	cytosol	ATP-binding | DNA replication | DNA-binding | Helicase | Hydrolase | Isomerase | Nucleotide-binding | Primosome | Reference proteome		The main replicative DNA helicase, it participates in initiation and elongation during chromosome replication. Travels ahead of the DNA replisome, separating dsDNA into templates for DNA synthesis. A processive ATP-dependent 5'-3' DNA helicase it has DNA-dependent ATPase activity
Hyalomma marginatum	34627	A0A8S4BTD3	Twin-arginine translocase subunit TatB		97	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BTF1	Sodium:solute symporter family protein		34	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BTF9	Uncharacterized protein		411	Unreviewed					Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BUG7	TolR		141	Unreviewed	Cell membrane	cell division | protein transport	transmembrane transporter activity	plasma membrane	Cell cycle | Cell division | Cell inner membrane | Cell membrane | Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BUF8	Uncharacterized protein		31	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUF0	Uncharacterized protein		43	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUD9	Chromosomal replication initiator protein DnaA-like protein		220	Unreviewed		DNA replication initiation	DNA replication origin binding	plasma membrane	Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUC8	D-alanine--D-alanine ligase		272	Unreviewed	Membrane	cell division	ligase activity	membrane	Cell cycle | Cell division | Cell inner membrane | Cell membrane | Ligase | Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BUA5	Penicillin-binding protein 2		606	Unreviewed	Cell membrane | Membrane	cell wall organization | proteolysis | regulation of cell shape	penicillin binding | peptidoglycan L,D-transpeptidase activity | serine-type D-Ala-D-Ala carboxypeptidase activity	plasma membrane	Cell inner membrane | Cell membrane | Cell shape | Cell wall biogenesis/degradation | Hydrolase | Membrane | Peptidoglycan synthesis | Protease | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BU95	3'-5' exonuclease		204	Unreviewed		nucleobase-containing compound metabolic process	3'-5' exonuclease activity | nucleic acid binding		Exonuclease | Hydrolase | Nuclease | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BU83	Type IV secretion system protein VirB9		249	Unreviewed					Reference proteome | Signal		
Hyalomma marginatum	34627	A0A8S4BU70	RNA methyltransferase		241	Unreviewed		tRNA nucleoside ribose methylation	RNA binding | RNA methyltransferase activity	cytosol	Methyltransferase | Reference proteome | S-adenosyl-L-methionine | Transferase		
Hyalomma marginatum	34627	A0A8S4BU59	HU family DNA-binding protein		92	Unreviewed			DNA binding | structural constituent of chromatin	cytosol	DNA-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BU45	FtsH protease activity modulator HflK		385	Unreviewed	Membrane	proteolysis	peptidase activity	membrane	Hydrolase | Membrane | Protease | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BU34	Uncharacterized protein		43	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BU26	Uncharacterized protein		52	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BU09	Acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase		278	Unreviewed		lipid A biosynthetic process	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity	membrane	Acyltransferase | Cytoplasm | Lipid A biosynthesis | Lipid biosynthesis | Lipid metabolism | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BTZ7	50S ribosomal protein L23		96	Unreviewed		translation	rRNA binding | structural constituent of ribosome	ribonucleoprotein complex | ribosome	Reference proteome | Ribonucleoprotein | Ribosomal protein | RNA-binding | rRNA-binding		
Hyalomma marginatum	34627	A0A8S4BTY7	50S ribosomal protein L5		181	Unreviewed		translation	structural constituent of ribosome	ribonucleoprotein complex | ribosome	Reference proteome | Ribonucleoprotein | Ribosomal protein		
Hyalomma marginatum	34627	A0A8S4BTW2	50S ribosomal protein L7/L12		121	Unreviewed		translation	mRNA binding | structural constituent of ribosome	cytoplasm | ribonucleoprotein complex | ribosome	Reference proteome | Ribonucleoprotein | Ribosomal protein		
Hyalomma marginatum	34627	A0A8S4BTV4	Uncharacterized protein		59	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BTU2	SDR family NAD(P)-dependent oxidoreductase		174	Unreviewed			oxidoreductase activity		Oxidoreductase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BTT3	Uncharacterized protein		57	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BTS1	Glutamine synthetase type I		378	Unreviewed		glutamine biosynthetic process | nitrogen utilization	glutamine synthetase activity	cytoplasm | membrane	Reference proteome		
Hyalomma marginatum	34627	A0A8S4BTR1	Uncharacterized protein		51	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BTN7	Uncharacterized protein		125	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BTM6	Uncharacterized protein		195	Unreviewed					Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BTL6	Uncharacterized protein		71	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BTI3	O-methyltransferase family protein		216	Unreviewed		methylation	O-methyltransferase activity | S-adenosylmethionine-dependent methyltransferase activity		Methyltransferase | Reference proteome | S-adenosyl-L-methionine | Transferase		
Hyalomma marginatum	34627	A0A8S4BTH0	Uncharacterized protein		49	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BTE2	Cytochrome C oxidase, mono-heme subunit/FixO		243	Unreviewed			electron transfer activity | heme binding | metal ion binding		Heme | Iron | Membrane | Metal-binding | Reference proteome | Transmembrane | Transmembrane helix		Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
Hyalomma marginatum	34627	A0A8S4C4M3	Lon protease homolog		794	Unreviewed	Cytoplasm	protein catabolic process | proteolysis	ATP binding | ATP hydrolysis activity | ATP-dependent peptidase activity | sequence-specific DNA binding | serine-type endopeptidase activity	cytoplasm	ATP-binding | Cytoplasm | Hydrolase | Nucleotide-binding | Protease | Reference proteome | Serine protease | Stress response		
Hyalomma marginatum	34627	A0A8S4C4L3	Ankyrin repeat domain-containing protein		733	Unreviewed	Target cell membrane	exocytosis		host cell presynaptic membrane | other organism cell membrane	ANK repeat | Exocytosis | Membrane | Neurotoxin | Presynaptic neurotoxin | Reference proteome | Repeat | Target cell membrane | Target membrane | Toxin		
Hyalomma marginatum	34627	A0A8S4C4K2	2Fe-2S ferredoxin		110	Unreviewed		P450-containing electron transport chain	2 iron, 2 sulfur cluster binding | electron transfer activity | metal ion binding	mitochondrion	2Fe-2S | Electron transport | Iron | Iron-sulfur | Metal-binding | Reference proteome | Transport		
Hyalomma marginatum	34627	A0A8S4C3I2	[acyl-carrier-protein] S-malonyltransferase		319	Unreviewed		fatty acid biosynthetic process	[acyl-carrier-protein] S-malonyltransferase activity	mitochondrion	Acyltransferase | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C3H9	ribonuclease III		219	Unreviewed		box C/D sno(s)RNA processing | miRNA processing | rRNA processing | termination of RNA polymerase II transcription, exosome-dependent | U4 snRNA 3'-end processing	double-stranded RNA binding | ribonuclease III activity		Endonuclease | Hydrolase | Nuclease | Reference proteome | RNA-binding		
Hyalomma marginatum	34627	A0A8S4C3H0	hydroxymethylbilane synthase		206	Unreviewed		heme biosynthetic process	hydroxymethylbilane synthase activity	cytoplasm	Porphyrin biosynthesis | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C3G6	Cytochrome c oxidase subunit 1		475	Unreviewed	Cell membrane	aerobic respiration | electron transport coupled proton transport | respiratory electron transport chain	cytochrome-c oxidase activity | heme binding | metal ion binding	plasma membrane	Cell membrane | Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Reference proteome | Translocase | Transmembrane | Transmembrane helix | Transport		
Hyalomma marginatum	34627	A0A8S4C3E3	tRNA pseudouridine synthase		246	Unreviewed		tRNA pseudouridine synthesis	RNA binding | tRNA pseudouridine(38-40) synthase activity		Isomerase | Reference proteome | tRNA processing		
Hyalomma marginatum	34627	A0A8S4C3B3	Acyl carrier protein		114	Unreviewed			acyl binding | acyl carrier activity		Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Phosphopantetheine | Phosphoprotein | Reference proteome		Carrier of the growing fatty acid chain in fatty acid biosynthesis
Hyalomma marginatum	34627	A0A8S4C381	tRNA dimethylallyltransferase		295	Unreviewed		tRNA modification	ATP binding | tRNA dimethylallyltransferase activity		ATP-binding | Magnesium | Nucleotide-binding | Reference proteome | Transferase | tRNA processing		
Hyalomma marginatum	34627	A0A8S4C379	Bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU		434	Unreviewed	Cytoplasm	cell morphogenesis | cell wall organization | regulation of cell shape | UDP-N-acetylglucosamine biosynthetic process	glucosamine-1-phosphate N-acetyltransferase activity | magnesium ion binding | UDP-N-acetylglucosamine diphosphorylase activity	cytoplasm	Acyltransferase | Cell shape | Cell wall biogenesis/degradation | Cytoplasm | Magnesium | Metal-binding | Multifunctional enzyme | Nucleotidyltransferase | Peptidoglycan synthesis | Reference proteome | Repeat | Transferase		
Hyalomma marginatum	34627	A0A8S4C372	ATP-dependent metallopeptidase FtsH/Yme1/Tma family protein		644	Unreviewed	Membrane	proteolysis | PSII associated light-harvesting complex II catabolic process	ATP binding | ATP hydrolysis activity | ATP-dependent peptidase activity | metalloendopeptidase activity | zinc ion binding	plasma membrane	ATP-binding | Cell membrane | Hydrolase | Membrane | Metal-binding | Metalloprotease | Nucleotide-binding | Protease | Reference proteome | Transmembrane | Transmembrane helix | Zinc		
Hyalomma marginatum	34627	A0A8S4C354	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase		164	Unreviewed		folic acid biosynthetic process	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity | ATP binding | kinase activity		ATP-binding | Folate biosynthesis | Kinase | Nucleotide-binding | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C342	tryptophan--tRNA ligase		331	Unreviewed	Mitochondrion	tryptophanyl-tRNA aminoacylation	ATP binding | tryptophan-tRNA ligase activity	mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C339	Aspartate-semialdehyde dehydrogenase		335	Unreviewed		methionine biosynthetic process | threonine biosynthetic process	aspartate-semialdehyde dehydrogenase activity | NAD binding | NADP binding | protein dimerization activity		Amino-acid biosynthesis | NADP | Oxidoreductase | Reference proteome | Threonine biosynthesis		Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine
Hyalomma marginatum	34627	A0A8S4C303	Transcriptional repressor		139	Unreviewed	Cytoplasm	negative regulation of DNA-templated transcription | regulation of secondary metabolite biosynthetic process	DNA-binding transcription factor activity | transcription cis-regulatory region binding | zinc ion binding	cytosol	Cytoplasm | DNA-binding | Metal-binding | Reference proteome | Repressor | Transcription | Transcription regulation | Zinc		
Hyalomma marginatum	34627	A0A8S4C2Y1	3-oxoacyl-[acyl-carrier-protein] synthase		416	Unreviewed	Cell inner membrane	fatty acid biosynthetic process	3-oxoacyl-[acyl-carrier-protein] synthase activity	plasma membrane	Acyltransferase | Cell inner membrane | Cell membrane | Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Membrane | Nodulation | Reference proteome | Transferase | Transmembrane | Transmembrane helix		Proposed to synthesize NOD factor fatty acyl chain. Involved in the synthesis of a highly unsaturated fatty acid moiety, which forms part of a lipo-oligosaccharide that is responsible for host specificity
Hyalomma marginatum	34627	A0A8S4C2X7	C-1-tetrahydrofolate synthase, cytoplasmic		292	Unreviewed		tetrahydrofolate interconversion	formate-tetrahydrofolate ligase activity | methenyltetrahydrofolate cyclohydrolase activity | methylenetetrahydrofolate dehydrogenase (NADP+) activity	cytosol	Hydrolase | Multifunctional enzyme | NADP | One-carbon metabolism | Oxidoreductase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C2X4	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase		286	Unreviewed		terpenoid biosynthetic process	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity | ATP binding		ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C2S6	CDP-diacylglycerol--serine O-phosphatidyltransferase		255	Unreviewed	Endomembrane system	phospholipid biosynthetic process	cardiolipin synthase (CMP-forming) | CDP-diacylglycerol-serine O-phosphatidyltransferase activity	endomembrane system | membrane	Lipid biosynthesis | Lipid metabolism | Membrane | Phospholipid biosynthesis | Phospholipid metabolism | Reference proteome | Transferase | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4C2Q0	inorganic diphosphatase		175	Unreviewed		phosphate-containing compound metabolic process	inorganic diphosphate phosphatase activity | magnesium ion binding	cytoplasm	Hydrolase | Magnesium | Metal-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C2P8	Small ribosomal subunit protein uS12c		124	Unreviewed		translation	rRNA binding | structural constituent of ribosome	small ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein | RNA-binding | rRNA-binding		With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits
Hyalomma marginatum	34627	A0A8S4C2N3	5-formyltetrahydrofolate cyclo-ligase		202	Unreviewed		folic acid-containing compound biosynthetic process | tetrahydrofolate interconversion	5-formyltetrahydrofolate cyclo-ligase activity | ATP binding | metal ion binding		ATP-binding | Magnesium | Metal-binding | Nucleotide-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C2L3	Carbonic anhydrase		122	Unreviewed			carbonate dehydratase activity | zinc ion binding		Lyase | Metal-binding | Reference proteome | Zinc		Reversible hydration of carbon dioxide
Hyalomma marginatum	34627	A0A8S4C2J0	cardiolipin synthase (CMP-forming)		180	Unreviewed	Membrane	glycerophospholipid biosynthetic process	cardiolipin synthase (CMP-forming) | CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	membrane	Lipid biosynthesis | Lipid metabolism | Membrane | Phospholipid biosynthesis | Phospholipid metabolism | Reference proteome | Transferase | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4C2E8	3-oxoacyl-[acyl-carrier-protein] reductase		140	Unreviewed		siderophore biosynthetic process	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity		Reference proteome		
Hyalomma marginatum	34627	A0A8S4C2E2	Alkyl transferase		232	Unreviewed		polyprenol biosynthetic process	ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity		Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C2D9	exodeoxyribonuclease III		263	Unreviewed		DNA repair	DNA binding | double-stranded DNA 3'-5' DNA exonuclease activity | endonuclease activity | metal ion binding		DNA damage | DNA repair | Hydrolase | Magnesium | Manganese | Metal-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C2C3	arginine--tRNA ligase		565	Unreviewed		arginyl-tRNA aminoacylation	arginine-tRNA ligase activity | ATP binding	cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C2B7	DNA repair protein RecN		555	Unreviewed		DNA recombination | DNA repair	ATP binding		ATP-binding | DNA damage | DNA repair | Nucleotide-binding | Reference proteome		May be involved in recombinational repair of damaged DNA
Hyalomma marginatum	34627	A0A8S4C3J7	UvrABC system protein B		662	Unreviewed	Cytoplasm	nucleotide-excision repair	ATP binding | ATP hydrolysis activity | DNA binding | nuclease activity	cytoplasm | excinuclease repair complex	ATP-binding | Cytoplasm | DNA damage | DNA excision | DNA repair | Excision nuclease | Nucleotide-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C4M1	Obg-like ATPase 1		364	Unreviewed	Cytoplasm		ATP binding | ATP hydrolysis activity | GTP binding | metal ion binding | ribosomal large subunit binding	cytoplasm	ATP-binding | Cytoplasm | Hydrolase | Metal-binding | Nucleotide-binding | Reference proteome		Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP
Hyalomma marginatum	34627	A0A8S4C3K4	Signal recognition particle subunit SRP54		447	Unreviewed		SRP-dependent cotranslational protein targeting to membrane	7S RNA binding | GTP binding | GTPase activity	signal recognition particle, endoplasmic reticulum targeting	GTP-binding | Hydrolase | Nucleotide-binding | Reference proteome | Ribonucleoprotein | RNA-binding | Signal recognition particle		
Hyalomma marginatum	34627	A0A8S4C3K9	succinate dehydrogenase		170	Unreviewed		respiratory electron transport chain | tricarboxylic acid cycle	2 iron, 2 sulfur cluster binding | 3 iron, 4 sulfur cluster binding | 4 iron, 4 sulfur cluster binding | electron transfer activity | metal ion binding | succinate dehydrogenase (quinone) activity		2Fe-2S | 3Fe-4S | 4Fe-4S | Electron transport | Iron | Iron-sulfur | Metal-binding | Oxidoreductase | Reference proteome | Transport | Tricarboxylic acid cycle		
Hyalomma marginatum	34627	A0A8S4C4J9	Translation initiation factor IF-1, chloroplastic		79	Unreviewed			ribosome binding | RNA binding | translation initiation factor activity	cytosol	Initiation factor | Protein biosynthesis | Reference proteome		One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex
Hyalomma marginatum	34627	A0A8S4C4J6	Large ribosomal subunit protein uL3c		226	Unreviewed		translation	rRNA binding | structural constituent of ribosome	ribonucleoprotein complex | ribosome	Reference proteome | Ribonucleoprotein | Ribosomal protein | RNA-binding | rRNA-binding		
Hyalomma marginatum	34627	A0A8S4C4I3	Protein translocase subunit SecY		445	Unreviewed	Membrane	protein transport		membrane	Membrane | Protein transport | Reference proteome | Translocation | Transmembrane | Transmembrane helix | Transport		The central subunit of the protein translocation channel SecYE. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug
Hyalomma marginatum	34627	A0A8S4C4I0	Large ribosomal subunit protein uL1		233	Unreviewed		translation	rRNA binding | structural constituent of ribosome	cytosolic large ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein | RNA-binding | rRNA-binding		
Hyalomma marginatum	34627	A0A8S4C4H9	1-deoxy-D-xylulose-5-phosphate synthase		625	Unreviewed		terpenoid biosynthetic process | thiamine biosynthetic process	1-deoxy-D-xylulose-5-phosphate synthase activity | metal ion binding	cytosol	Isoprene biosynthesis | Magnesium | Metal-binding | Reference proteome | Thiamine biosynthesis | Thiamine pyrophosphate | Transferase		
Hyalomma marginatum	34627	A0A8S4C4H6	dCMP deaminase		269	Unreviewed		nucleotide biosynthetic process	dCMP deaminase activity | zinc ion binding	cytoplasm	Hydrolase | Metal-binding | Nucleotide biosynthesis | Reference proteome | Zinc		
Hyalomma marginatum	34627	A0A8S4C4F5	Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial		96	Unreviewed	Mitochondrion	glutaminyl-tRNAGln biosynthesis via transamidation | mitochondrial translation | regulation of translational fidelity	ATP binding | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	glutamyl-tRNA(Gln) amidotransferase complex | mitochondrion	ATP-binding | Ligase | Mitochondrion | Nucleotide-binding | Protein biosynthesis | Reference proteome		Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
Hyalomma marginatum	34627	A0A8S4C4B9	Elongation factor G, mitochondrial		695	Unreviewed	Mitochondrion	mitochondrial translational elongation | ribosome disassembly	GTP binding | GTPase activity | translation elongation factor activity	mitochondrion	Elongation factor | GTP-binding | Mitochondrion | Nucleotide-binding | Protein biosynthesis | Reference proteome		Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Hyalomma marginatum	34627	A0A8S4C4B7	Acetyltransferase component of pyruvate dehydrogenase complex		421	Unreviewed	Mitochondrion	pyruvate decarboxylation to acetyl-CoA	dihydrolipoyllysine-residue acetyltransferase activity	mitochondrion | pyruvate dehydrogenase complex	Acyltransferase | Lipoyl | Pyruvate | Reference proteome | Transferase | Transit peptide		The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Hyalomma marginatum	34627	A0A8S4C4B5	Mitochondrial inner membrane protease subunit		249	Unreviewed	Mitochondrion inner membrane	signal peptide processing	serine-type endopeptidase activity | signal peptidase activity	membrane protein complex | mitochondrial inner membrane | serine-type endopeptidase complex	Hydrolase | Membrane | Mitochondrion | Mitochondrion inner membrane | Protease | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C4B2	cysteine desulfurase		404	Unreviewed		[2Fe-2S] cluster assembly	cysteine desulfurase activity | iron-sulfur cluster binding | metal ion binding | pyridoxal phosphate binding	mitochondrial [2Fe-2S] assembly complex | nucleus	Iron | Iron-sulfur | Metal-binding | Pyridoxal phosphate | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C4A8	glycine--tRNA ligase		510	Unreviewed		glycyl-tRNA aminoacylation	ATP binding | glycine-tRNA ligase activity	cytosol	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C4A7	beta-N-acetylhexosaminidase		319	Unreviewed		carbohydrate metabolic process | peptidoglycan turnover	beta-N-acetylhexosaminidase activity		Glycosidase | Hydrolase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C489	Transcription elongation factor GreA		159	Unreviewed		DNA-templated transcription elongation | regulation of DNA-templated transcription elongation	DNA binding | RNA polymerase binding | translation elongation factor activity		DNA-binding | Elongation factor | Protein biosynthesis | Reference proteome | Transcription | Transcription regulation		Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
Hyalomma marginatum	34627	A0A8S4C479	phosphate acyltransferase		359	Unreviewed	Cytoplasm	fatty acid biosynthetic process | phospholipid biosynthetic process	phosphate:acyl-[acyl carrier protein] acyltransferase activity	cytoplasm	Acyltransferase | Cytoplasm | Lipid biosynthesis | Lipid metabolism | Phospholipid biosynthesis | Phospholipid metabolism | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C476	Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial		445	Unreviewed		glutamyl-tRNA aminoacylation	ATP binding | glutamate-tRNA ligase activity | glutamate-tRNA(Gln) ligase activity | tRNA binding	mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C454	histidine kinase		640	Unreviewed	Cell membrane		ATP binding | phosphorelay sensor kinase activity	plasma membrane	ATP-binding | Cell membrane | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Reference proteome | Transferase | Transmembrane | Transmembrane helix | Two-component regulatory system		
Hyalomma marginatum	34627	A0A8S4C451	Uroporphyrinogen decarboxylase		346	Unreviewed		heme biosynthetic process	uroporphyrinogen decarboxylase activity	cytosol	Decarboxylase | Lyase | Porphyrin biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C436	Methionine aminopeptidase		261	Unreviewed		proteolysis	initiator methionyl aminopeptidase activity | metal ion binding | metalloaminopeptidase activity		Aminopeptidase | Hydrolase | Metal-binding | Protease | Reference proteome		Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)
Hyalomma marginatum	34627	A0A8S4C426	NADH-ubiquinone oxidoreductase chain 4		508	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	membrane	Membrane | Reference proteome | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A8S4C414	tRNA-5-taurinomethyluridine 2-sulfurtransferase		356	Unreviewed		tRNA wobble position uridine thiolation	ATP binding | tRNA binding | tRNA-5-taurinomethyluridine 2-sulfurtransferase		ATP-binding | Disulfide bond | Nucleotide-binding | Reference proteome | RNA-binding | Transferase | tRNA processing | tRNA-binding		Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base
Hyalomma marginatum	34627	A0A8S4C401	fumarate hydratase		461	Unreviewed		fumarate metabolic process | malate metabolic process | tricarboxylic acid cycle	fumarate hydratase activity	mitochondrion	Lyase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C3V5	lipoyl synthase		304	Unreviewed	Mitochondrion		4 iron, 4 sulfur cluster binding | lipoate synthase activity | metal ion binding	mitochondrion	4Fe-4S | Cytoplasm | Iron | Iron-sulfur | Metal-binding | Reference proteome | S-adenosyl-L-methionine | Transferase		
Hyalomma marginatum	34627	A0A8S4C3R2	Protein arginine methyltransferase NDUFAF7		353	Unreviewed	Mitochondrion	methylation	protein-arginine omega-N symmetric methyltransferase activity	mitochondrion	Methyltransferase | Mitochondrion | Reference proteome | Transferase		Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)
Hyalomma marginatum	34627	A0A8S4C3P1	polyribonucleotide nucleotidyltransferase		768	Unreviewed		mRNA catabolic process | RNA processing	3'-5'-RNA exonuclease activity | metal ion binding | polyribonucleotide nucleotidyltransferase activity | RNA binding	cytosol	Cytoplasm | Magnesium | Metal-binding | Nucleotidyltransferase | Reference proteome | RNA-binding | Transferase		
Hyalomma marginatum	34627	A0A8S4C3N0	NADH-ubiquinone oxidoreductase chain 3		122	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity | oxidoreductase activity, acting on NAD(P)H	NADH dehydrogenase complex	Membrane | NAD | Reference proteome | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		
Hyalomma marginatum	34627	A0A8S4C3M5	Large ribosomal subunit protein uL24m		108	Unreviewed		translation	rRNA binding | structural constituent of ribosome	ribonucleoprotein complex | ribosome	Reference proteome | Ribonucleoprotein | Ribosomal protein | RNA-binding | rRNA-binding		
Hyalomma marginatum	34627	A0A8S4C3K7	Pseudouridine synthase		321	Unreviewed		enzyme-directed rRNA pseudouridine synthesis	pseudouridine synthase activity | RNA binding		Isomerase | Reference proteome | RNA-binding		Responsible for synthesis of pseudouridine from uracil
Hyalomma marginatum	34627	A0A8S4BUI8	Uncharacterized protein		69	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVQ1	MFS transporter		424	Unreviewed	Cell membrane		transmembrane transporter activity	plasma membrane	Cell membrane | Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BUK8	Uncharacterized protein		53	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW30	Uncharacterized protein		88	Unreviewed					Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BW24	Accessory factor UbiK family protein		102	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW20	Type IV secretion system protein VirB2		42	Unreviewed					Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BW19	Ribosome-recycling factor, mitochondrial		187	Unreviewed	Cytoplasm	cytoplasmic translational termination	ribosomal large subunit binding	cytosol	Cytoplasm | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW14	Intradiol ring-cleavage dioxygenase		209	Unreviewed			ferric iron binding | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen		Dioxygenase | Oxidoreductase | Reference proteome | Signal		
Hyalomma marginatum	34627	A0A8S4BW09	Peptidase M48		119	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW03	Ribonuclease protein J		549	Unreviewed		RNA 3'-end processing	exonuclease activity | metal ion binding | RNA binding		Cytoplasm | Exonuclease | Hydrolase | Metal-binding | Nuclease | Reference proteome | RNA-binding | Zinc		
Hyalomma marginatum	34627	A0A8S4BVZ9	Uncharacterized protein		67	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVZ1	MSF transporter		414	Unreviewed	Membrane		transmembrane transporter activity	membrane	Membrane | Reference proteome | Transmembrane | Transmembrane helix | Transport		
Hyalomma marginatum	34627	A0A8S4BVZ0	Flagellar motor protein MotA		281	Unreviewed	Cell membrane	chemotaxis | proton transmembrane transport		plasma membrane	Cell membrane | Cell projection | Chemotaxis | Cilium | Flagellar rotation | Flagellum | Hydrogen ion transport | Ion transport | Membrane | Reference proteome | Transmembrane | Transmembrane helix | Transport		
Hyalomma marginatum	34627	A0A8S4BVY7	ABC transporter ATP-binding protein		590	Unreviewed	Membrane		ABC-type oligopeptide transporter activity | ATP binding | ATP hydrolysis activity	membrane	ATP-binding | Membrane | Nucleotide-binding | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BVY2	Transposase		40	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVX9	Xaa-Pro aminopeptidase		572	Unreviewed			metal ion binding | metalloaminopeptidase activity	cytoplasm	Aminopeptidase | Hydrolase | Metal-binding | Protease | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVX2	HU family DNA-binding protein		93	Unreviewed			DNA binding | structural constituent of chromatin	cytosol	DNA-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVX0	Ketoacyl-ACP synthase III		319	Unreviewed		fatty acid biosynthetic process | secondary metabolite biosynthetic process	3-oxoacyl-[acyl-carrier-protein] synthase activity		Acyltransferase | Cytoplasm | Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BVW2	Class II fructose-bisphosphatase		313	Unreviewed		fructose 1,6-bisphosphate metabolic process | gluconeogenesis | glycerol metabolic process	fructose 1,6-bisphosphate 1-phosphatase activity | metal ion binding	cytosol	Carbohydrate metabolism | Hydrolase | Manganese | Metal-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVV7	Uncharacterized protein		50	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVU8	Cytochrome c maturation protein CcmE		169	Unreviewed	Membrane	cytochrome complex assembly | protein-heme linkage	heme binding | metal ion binding	plasma membrane	Cytochrome c-type biogenesis | Heme | Iron | Membrane | Metal-binding | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BVU7	Uncharacterized protein		49	Unreviewed					Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BVU0	Sodium:solute symporter family protein		64	Unreviewed					Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BVT5	CCA tRNA nucleotidyltransferase		400	Unreviewed		tRNA 3'-terminal CCA addition	metal ion binding | nucleotide binding | nucleotidyltransferase activity | tRNA binding		Magnesium | Metal-binding | Nucleotide-binding | Nucleotidyltransferase | Reference proteome | RNA-binding | Transferase | tRNA processing		
Hyalomma marginatum	34627	A0A8S4BVT0	PqqC-like protein		226	Unreviewed			oxidoreductase activity		Oxidoreductase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVS6	NusG-like N-terminal domain-containing protein		176	Unreviewed		DNA-templated transcription elongation | DNA-templated transcription termination | regulation of DNA-templated transcription elongation | transcription antitermination		cytosol	Reference proteome | Transcription | Transcription antitermination | Transcription regulation | Transcription termination		
Hyalomma marginatum	34627	A0A8S4BVS5	GS catalytic domain-containing protein		272	Unreviewed		glutamine biosynthetic process | polyamine catabolic process	glutamine synthetase activity		Ligase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVS1	ATP-binding cassette domain-containing protein		234	Unreviewed		transmembrane transport	ATP binding | ATP hydrolysis activity	membrane	ATP-binding | Nucleotide-binding | Reference proteome | Transport		
Hyalomma marginatum	34627	A0A8S4BVR3	D-Ala-D-Ala dipeptidase		406	Unreviewed		cell wall organization | proteolysis	dipeptidase activity | metal ion binding | metallopeptidase activity		Cell wall biogenesis/degradation | Dipeptidase | Hydrolase | Membrane | Metal-binding | Metalloprotease | Protease | Reference proteome | Transmembrane | Transmembrane helix | Zinc		
Hyalomma marginatum	34627	A0A8S4BVR0	Uncharacterized protein		95	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW32	Type IV secretion system protein		741	Unreviewed		protein secretion by the type IV secretion system			Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BW36	Glutaredoxin		109	Unreviewed			2 iron, 2 sulfur cluster binding | disulfide oxidoreductase activity | metal ion binding		2Fe-2S | Iron | Iron-sulfur | Metal-binding | Redox-active center | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW41	Sodium:solute symporter family protein		457	Unreviewed	Cell membrane	sodium ion transport	symporter activity	plasma membrane	Cell membrane | Ion transport | Membrane | Reference proteome | Sodium | Sodium transport | Symport | Transmembrane | Transmembrane helix | Transport		
Hyalomma marginatum	34627	A0A8S4BW43	Uncharacterized protein		58	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BWE6	Uncharacterized protein		47	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BWE2	CinA family protein		165	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BWD5	Uncharacterized protein		80	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BWD3	Uncharacterized protein		53	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BWC9	TAXI family TRAP transporter solute-binding subunit		330	Unreviewed					Reference proteome | Signal		
Hyalomma marginatum	34627	A0A8S4BWC8	30S ribosomal protein S7		157	Unreviewed		translation	rRNA binding | structural constituent of ribosome	small ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein | RNA-binding | rRNA-binding		
Hyalomma marginatum	34627	A0A8S4BWC4	Alanine racemase		372	Unreviewed		D-alanine biosynthetic process	alanine racemase activity | pyridoxal phosphate binding	cytosol	Isomerase | Pyridoxal phosphate | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BWC2	Sodium:solute symporter family protein		193	Unreviewed	Membrane		transmembrane transporter activity	plasma membrane	Membrane | Reference proteome | Transmembrane | Transmembrane helix | Transport		
Hyalomma marginatum	34627	A0A8S4BWB9	GNAT family N-acetyltransferase		201	Unreviewed			protein-N-terminal-alanine acetyltransferase activity	cytoplasm	Reference proteome		
Hyalomma marginatum	34627	A0A8S4BWB0	Uncharacterized protein		65	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BWA7	Uncharacterized protein		77	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BWA2	Uncharacterized protein		88	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BWA0	Putative 3'-5' exonuclease related to the exonuclease domain of PolB		270	Unreviewed			exonuclease activity | nucleic acid binding		Exonuclease | Hydrolase | Nuclease | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVQ4	Transposase		56	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW98	Uncharacterized protein		72	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW92	Sigma-54-dependent Fis family transcriptional regulator		444	Unreviewed	Nucleus	phosphorelay signal transduction system | regulation of DNA-templated transcription	ATP binding | sequence-specific DNA binding	nucleus	ATP-binding | Nucleotide-binding | Phosphoprotein | Reference proteome | Transcription | Transcription regulation		
Hyalomma marginatum	34627	A0A8S4BW83	Succinate dehydrogenase, cytochrome b556 subunit		141	Unreviewed	Membrane	tricarboxylic acid cycle	electron transfer activity | metal ion binding	membrane	Heme | Iron | Membrane | Metal-binding | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BW77	Fe-S cluster assembly scaffold IscU		131	Unreviewed		iron-sulfur cluster assembly	iron ion binding | iron-sulfur cluster binding	mitochondrion	Iron | Iron-sulfur | Metal-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW76	3-oxoacyl-[acyl-carrier-protein] reductase		78	Unreviewed			3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity		Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW70	Uncharacterized protein		86	Unreviewed					Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BW69	Ubiquitin-like protease family profile domain-containing protein		271	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW68	Outer membrane protein LolA		229	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW62	Uncharacterized protein		52	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW58	Uncharacterized protein		211	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW57	Uncharacterized protein		168	Unreviewed					Reference proteome | Signal		
Hyalomma marginatum	34627	A0A8S4BW54	Uncharacterized protein		62	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW49	Uncharacterized protein		72	Unreviewed					Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BW44	Zinc finger/thioredoxin putative domain-containing protein		231	Unreviewed					Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BW96	Flagellar basal body rod protein FlgC		156	Unreviewed					Cell projection | Cilium | Flagellum | Reference proteome | Signal		
Hyalomma marginatum	34627	A0A8S4BUJ8	Uncharacterized protein		66	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVQ2	Uncharacterized protein		40	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVP5	DNA primase		579	Unreviewed		DNA replication, synthesis of primer	DNA binding | DNA-directed RNA polymerase activity | zinc ion binding	cytoplasm | DNA-directed RNA polymerase complex	DNA replication | DNA-binding | DNA-directed RNA polymerase | Magnesium | Metal-binding | Nucleotidyltransferase | Primosome | Reference proteome | Transcription | Transferase | Zinc | Zinc-finger		
Hyalomma marginatum	34627	A0A8S4BV87	Uncharacterized protein		61	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV82	Uncharacterized protein		46	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV80	Uncharacterized protein		52	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV71	Uncharacterized protein		103	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV69	Exopolyphosphatase		340	Unreviewed		regulation of transcription by RNA polymerase II			Reference proteome | Signal		
Hyalomma marginatum	34627	A0A8S4BV62	GapR-like DNA-binding domain-containing protein		59	Unreviewed			DNA binding		Coiled coil | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV54	CarD family transcriptional regulator		170	Unreviewed		rRNA transcription			Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV42	UDP-MurNAc-pentapeptide synthetase		461	Unreviewed		cell division | cell wall organization | regulation of cell shape	ATP binding | UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity		ATP-binding | Cell cycle | Cell division | Cell shape | Cell wall biogenesis/degradation | Cytoplasm | Ligase | Nucleotide-binding | Peptidoglycan synthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV35	Uncharacterized protein		32	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV30	Glycosyltransferase family 25 (LPS biosynthesis protein)		281	Unreviewed					Reference proteome | Signal		
Hyalomma marginatum	34627	A0A8S4BV23	Crossover junction endodeoxyribonuclease RuvC		158	Unreviewed		DNA recombination | DNA repair	DNA binding | DNA endonuclease activity | hydrolase activity | metal ion binding		Cytoplasm | DNA damage | DNA recombination | DNA repair | DNA-binding | Endonuclease | Hydrolase | Magnesium | Metal-binding | Nuclease | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV18	Sodium:solute symporter family protein		69	Unreviewed					Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BV14	ATP-binding cassette domain-containing protein		250	Unreviewed			ATP binding | ATP hydrolysis activity		ATP-binding | Nucleotide-binding | Reference proteome | Transport		
Hyalomma marginatum	34627	A0A8S4BV02	DEAD/DEAH box helicase		332	Unreviewed		DNA repair	DNA helicase activity | hydrolase activity		ATP-binding | Helicase | Hydrolase | Nucleotide-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUZ5	Uncharacterized protein		111	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUY0	Cell division protein ZapA		107	Unreviewed		cell division			Cell cycle | Cell division | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUX5	Uncharacterized protein		108	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUW8	Ribulose-phosphate 3-epimerase	rpe_2	46	Unreviewed		carbohydrate metabolic process	metal ion binding | racemase and epimerase activity, acting on carbohydrates and derivatives		Isomerase | Metal-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUW0	Uncharacterized protein		59	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUV4	Protein kinase domain-containing protein		419	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUU8	Septation protein A		178	Unreviewed				plasma membrane	Cell membrane | Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BUT7	VCBS repeat containing protein		63	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUS5	Uncharacterized protein		154	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUP8	Transketolase	tkt	49	Unreviewed		pentose-phosphate shunt	transketolase activity	cytosol	Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUN4	Elongation factor P		186	Unreviewed	Cytoplasm	peptide biosynthetic process	translation elongation factor activity	cytosol	Cytoplasm | Elongation factor | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BUM4	Type IV secretion system protein		849	Unreviewed		protein secretion by the type IV secretion system			Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BUL6	Uncharacterized protein		31	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV88	Uncharacterized protein		61	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV95	AsmA family protein		909	Unreviewed		regulation of protein targeting to membrane		plasma membrane	Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV97	50S ribosomal protein L27		84	Unreviewed		translation	structural constituent of ribosome	mitochondrial large ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein		
Hyalomma marginatum	34627	A0A8S4BV99	Uncharacterized protein		33	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVN8	Magnesium transporter MgtE intracellular domain-containing protein		177	Unreviewed					Coiled coil | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVN0	RNA pyrophosphohydrolase		162	Unreviewed		nucleoside phosphate metabolic process | ribose phosphate metabolic process	bis(5'-adenosyl)-pentaphosphatase activity | guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity		Hydrolase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVM9	Uncharacterized protein		41	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVM4	Uncharacterized protein		65	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVM1	Uncharacterized protein		93	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVL1	Quinone oxidoreductase		323	Unreviewed			mRNA 3'-UTR AU-rich region binding | NADPH binding | quinone reductase (NADPH) activity	cytosol	NADP | Oxidoreductase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVK8	tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB		431	Unreviewed			4 iron, 4 sulfur cluster binding | metal ion binding | tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity	cytosol	4Fe-4S | Iron | Iron-sulfur | Metal-binding | Reference proteome | S-adenosyl-L-methionine		
Hyalomma marginatum	34627	A0A8S4BVK2	Flagellar M-ring protein FliF		537	Unreviewed	Bacterial flagellum basal body | Cell membrane		cytoskeletal motor activity	plasma membrane	Bacterial flagellum | Cell membrane | Cell projection | Cilium | Flagellum | Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BVK0	YbaB/EbfC family nucleoid-associated protein		103	Unreviewed			DNA binding	cytosol	Coiled coil | DNA-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVJ7	Uncharacterized protein		37	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVJ5	Uncharacterized protein		103	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVJ1	ParA family protein		204	Unreviewed			rRNA (guanine-N7-)-methyltransferase activity	cytosol	Cytoplasm | Reference proteome | rRNA processing | Transferase		
Hyalomma marginatum	34627	A0A8S4BVI7	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase		348	Unreviewed		lipid A biosynthetic process	N-acyltransferase activity	membrane	Acyltransferase | Lipid A biosynthesis | Lipid biosynthesis | Lipid metabolism | Reference proteome | Repeat | Transferase		
Hyalomma marginatum	34627	A0A8S4C2A3	UvrABC system protein A	uvrA	957	Unreviewed	Cytoplasm	nucleotide-excision repair	ATP binding | ATP hydrolysis activity | DNA binding | nuclease activity | zinc ion binding	cytoplasm | excinuclease repair complex	ATP-binding | Cytoplasm | DNA damage | DNA excision | DNA repair | DNA-binding | Excision nuclease | Metal-binding | Nucleotide-binding | Reference proteome | Repeat | Zinc | Zinc-finger		
Hyalomma marginatum	34627	A0A8S4BVI5	FG-GAP repeat-containing protein		64	Unreviewed					Glycoprotein | Reference proteome | Repeat | Signal		
Hyalomma marginatum	34627	A0A8S4BVG8	30S ribosomal protein S8		132	Unreviewed		translation	structural constituent of ribosome	cytoplasm | ribonucleoprotein complex | ribosome	Reference proteome | Ribonucleoprotein | Ribosomal protein		
Hyalomma marginatum	34627	A0A8S4BVG4	Uncharacterized protein		76	Unreviewed					Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BVE9	30S ribosomal protein S9		146	Unreviewed		translation	RNA binding | structural constituent of ribosome	cytosolic small ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein		
Hyalomma marginatum	34627	A0A8S4BVE5	Uncharacterized protein		99	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVE4	Transcription antitermination factor NusB		158	Unreviewed		DNA-templated transcription termination | transcription antitermination	RNA binding	cytosol	Reference proteome | RNA-binding | Transcription | Transcription antitermination | Transcription regulation		
Hyalomma marginatum	34627	A0A8S4BVD9	Lipoprotein		96	Unreviewed					Reference proteome | Signal		
Hyalomma marginatum	34627	A0A8S4BVC4	Stringent starvation protein B		170	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVC1	Uncharacterized protein		55	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVC0	Nucleotidyl transferase domain-containing protein		137	Unreviewed		GDP-mannose biosynthetic process	mannose-1-phosphate guanylyltransferase (GTP) activity		Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVB6	Branched chain amino acid aminotransferase		48	Unreviewed			transaminase activity		Aminotransferase | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BVB3	Type IV secretion system protein VirB6		494	Unreviewed		protein secretion by the type IV secretion system			Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BVB0	Uncharacterized protein		83	Unreviewed					Reference proteome | Signal		
Hyalomma marginatum	34627	A0A8S4BVA5	Uncharacterized protein		70	Unreviewed					Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVH5	VCBS repeat containing protein		78	Unreviewed					Reference proteome | Signal		
Hyalomma marginatum	34627	A0A8S4C2A1	Alpha-MPP		419	Unreviewed		proteolysis	metal ion binding | metalloendopeptidase activity		Reference proteome		Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins
Hyalomma marginatum	34627	A0A8S4C4X5	Ubiquinone biosynthesis protein		197	Unreviewed	Mitochondrion	ubiquinone biosynthetic process	lipid binding	mitochondrial inner membrane	Lipid-binding | Mitochondrion | Reference proteome | Transit peptide | Ubiquinone biosynthesis		Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration
Hyalomma marginatum	34627	A0A8S4C257	Threonylcarbamoyl-AMP synthase		198	Unreviewed	Cytoplasm	regulation of translational fidelity | tRNA processing	ATP binding | double-stranded RNA binding | L-threonylcarbamoyladenylate synthase | tRNA binding	cytoplasm	ATP-binding | Cytoplasm | Nucleotide-binding | Nucleotidyltransferase | Reference proteome | Transferase | tRNA processing		
Hyalomma marginatum	34627	A0A889ZE21	Cytochrome c oxidase subunit 2	COX2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A889ZE18	NADH-ubiquinone oxidoreductase chain 5	ND5	552	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A889ZDZ9	Cytochrome c oxidase subunit 3	COX3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A889ZDH2	NADH-ubiquinone oxidoreductase chain 5	ND5	552	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A889ZDG3	Cytochrome b	CYTB	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma marginatum	34627	A0A889ZDE0	Cytochrome c oxidase subunit 3	COX3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A889ZD67	NADH-ubiquinone oxidoreductase chain 5	ND5	552	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A889ZCV0	ATP synthase subunit a	ATP6	221	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Hyalomma marginatum	34627	A0A889ZCQ7	NADH-ubiquinone oxidoreductase chain 4	ND4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A889Q3L8	NADH-ubiquinone oxidoreductase chain 3	ND3	113	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Hyalomma marginatum	34627	A0A889Q3G5	Cytochrome c oxidase subunit 2	COII	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A889Q3E6	NADH-ubiquinone oxidoreductase chain 5	ND5	552	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A889Q332	NADH-ubiquinone oxidoreductase chain 4	ND4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A889Q322	NADH-ubiquinone oxidoreductase chain 2	ND2	320	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A889Q310	ATP synthase subunit a	ATP6	221	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Hyalomma marginatum	34627	A0A889Q302	Cytochrome b	CYTB	359	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma marginatum	34627	A0A7T3U9J3	Cytochrome b	cytB	209	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma marginatum	34627	A0A7T3U9D3	Cytochrome b	cytB	209	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma marginatum	34627	A0A6C0RLD0	Cytochrome c oxidase subunit 1		141	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A6C0RKE6	Cytochrome c oxidase subunit 1		145	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A6C0RKB9	Cytochrome c oxidase subunit 1		138	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A6C0RJH0	Cytochrome c oxidase subunit 1		102	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A6C0RI54	Cytochrome c oxidase subunit 1		143	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A6C0RHY3	Cytochrome c oxidase subunit 1		141	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A2S1N565	Cytochrome b		212	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma marginatum	34627	A0A2S1N539	Cytochrome b		212	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma marginatum	34627	A0A2S1N538	Cytochrome b		213	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma marginatum	34627	A0A889ZE33	NADH-ubiquinone oxidoreductase chain 1	ND1	334	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A889ZE42	NADH-ubiquinone oxidoreductase chain 3	ND3	113	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Hyalomma marginatum	34627	A0A8S4BT96	aconitate hydratase		890	Unreviewed	Cytoplasm	tricarboxylic acid metabolic process	4 iron, 4 sulfur cluster binding | aconitate hydratase activity | metal ion binding	cytoplasm	4Fe-4S | Cytoplasm | Iron | Iron-sulfur | Lyase | Metal-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BTJ2	GTPase Era, mitochondrial		296	Unreviewed		ribosomal small subunit assembly	GTP binding | ribosomal small subunit binding | rRNA binding		GTP-binding | Nucleotide-binding | Reference proteome | RNA-binding		
Hyalomma marginatum	34627	A0A8S4BVN7	Superoxide dismutase		207	Unreviewed			metal ion binding | superoxide dismutase activity		Iron | Manganese | Metal-binding | Oxidoreductase | Reference proteome		Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Hyalomma marginatum	34627	A0A8S4BVN6	P-type Cu(+) transporter		791	Unreviewed	Cell membrane | Golgi apparatus, trans-Golgi network membrane | Membrane	copper ion homeostasis	ATP binding | ATP hydrolysis activity | copper ion binding | P-type divalent copper transporter activity | P-type monovalent copper transporter activity	plasma membrane | trans-Golgi network	ATP-binding | Cell membrane | Copper | Copper transport | Ion transport | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Reference proteome | Translocase | Transmembrane | Transmembrane helix | Transport		
Hyalomma marginatum	34627	A0A8S4BVL7	peptidylprolyl isomerase		434	Unreviewed		'de novo' cotranslational protein folding | protein transport | protein unfolding	peptidyl-prolyl cis-trans isomerase activity | protein folding chaperone | ribosome binding		Chaperone | Isomerase | Reference proteome | Rotamase		
Hyalomma marginatum	34627	A0A8S4BVK4	Inositol-1-monophosphatase		265	Unreviewed		inositol metabolic process | phosphatidylinositol phosphate biosynthetic process | signal transduction	inositol monophosphate 1-phosphatase activity | metal ion binding		Hydrolase | Magnesium | Metal-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVI0	Glutamine-dependent NAD(+) synthetase		547	Unreviewed		NAD+ biosynthetic process	ATP binding | glutaminase activity | NAD+ synthase (glutamine-hydrolyzing) activity	cytoplasm	ATP-binding | Ligase | NAD | Nucleotide-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVH8	Small ribosomal subunit protein uS19c		93	Unreviewed		ribosomal small subunit assembly | translation	rRNA binding | structural constituent of ribosome	cytoplasm | small ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein | RNA-binding | rRNA-binding		
Hyalomma marginatum	34627	A0A8S4BVH2	UDP-3-O-acyl-N-acetylglucosamine deacetylase		284	Unreviewed		lipid A biosynthetic process | lipid X metabolic process	metal ion binding | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity	membrane	Hydrolase | Lipid A biosynthesis | Lipid biosynthesis | Lipid metabolism | Metal-binding | Reference proteome | Zinc		Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses
Hyalomma marginatum	34627	A0A8S4BVG6	Dihydrolipoyl dehydrogenase		466	Unreviewed		2-oxoglutarate metabolic process	dihydrolipoyl dehydrogenase (NADH) activity | flavin adenine dinucleotide binding	mitochondrion | oxoglutarate dehydrogenase complex	Disulfide bond | FAD | Flavoprotein | NAD | Nucleotide-binding | Oxidoreductase | Redox-active center | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVG2	DNA-directed RNA polymerase		343	Unreviewed		DNA-templated transcription	DNA binding | DNA-directed RNA polymerase activity | protein dimerization activity	cytoplasm | DNA-directed RNA polymerase complex	DNA-directed RNA polymerase | Nucleotidyltransferase | Reference proteome | Transcription | Transferase		DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Hyalomma marginatum	34627	A0A8S4BVF2	DNA-directed RNA polymerase subunit	rpoC	1408	Unreviewed		DNA-templated transcription	DNA binding | DNA-directed RNA polymerase activity | metal ion binding	DNA-directed RNA polymerase complex | nuclear lumen	DNA-directed RNA polymerase | Metal-binding | Nucleotidyltransferase | Reference proteome | Transcription | Transferase		DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Hyalomma marginatum	34627	A0A8S4BVE0	S-adenosylmethionine synthase		376	Unreviewed		one-carbon metabolic process | S-adenosylmethionine biosynthetic process	ATP binding | metal ion binding | methionine adenosyltransferase activity		ATP-binding | Magnesium | Metal-binding | Nucleotide-binding | One-carbon metabolism | Potassium | Reference proteome | Transferase		Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Hyalomma marginatum	34627	A0A8S4BVD8	ribonuclease H		144	Unreviewed		DNA replication, removal of RNA primer	metal ion binding | nucleic acid binding | RNA-DNA hybrid ribonuclease activity		Endonuclease | Hydrolase | Magnesium | Metal-binding | Nuclease | Reference proteome		Endonuclease that specifically degrades the RNA of RNA-DNA hybrids
Hyalomma marginatum	34627	A0A8S4BVD1	Large ribosomal subunit protein bL28c		102	Unreviewed		translation	structural constituent of ribosome	ribonucleoprotein complex | ribosome	Reference proteome | Ribonucleoprotein | Ribosomal protein		
Hyalomma marginatum	34627	A0A2S1N532	Cytochrome b		211	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma marginatum	34627	A0A8S4BVD0	peptidoglycan glycosyltransferase		616	Unreviewed		cell wall organization | proteolysis | regulation of cell shape	carboxypeptidase activity | penicillin binding | peptidoglycan glycosyltransferase activity		Carboxypeptidase | Cell shape | Cell wall biogenesis/degradation | Glycosyltransferase | Hydrolase | Membrane | Multifunctional enzyme | Peptidoglycan synthesis | Protease | Reference proteome | Transferase | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BVA4	Thioredoxin reductase		308	Unreviewed		removal of superoxide radicals	thioredoxin-disulfide reductase (NADPH) activity	cytoplasm	Disulfide bond | FAD | Flavoprotein | NADP | Oxidoreductase | Redox-active center | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV77	10 kDa heat shock protein, mitochondrial		97	Unreviewed			ATP binding | metal ion binding | protein folding chaperone | protein-folding chaperone binding | unfolded protein binding	mitochondrion	Chaperone | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BV74	RecA family profile 1 domain-containing protein		459	Unreviewed		recombinational repair	ATP binding | ATP-dependent DNA damage sensor activity | damaged DNA binding | hydrolase activity | zinc ion binding	cytosol	ATP-binding | DNA damage | DNA repair | DNA-binding | Hydrolase | Metal-binding | Nucleotide-binding | Reference proteome | Stress response | Zinc | Zinc-finger		
Hyalomma marginatum	34627	A0A8S4BV53	Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial		489	Unreviewed	Mitochondrion	glutaminyl-tRNAGln biosynthesis via transamidation | mitochondrial translation	ATP binding | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	glutamyl-tRNA(Gln) amidotransferase complex | mitochondrion	ATP-binding | Ligase | Mitochondrion | Nucleotide-binding | Protein biosynthesis | Reference proteome		Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
Hyalomma marginatum	34627	A0A8S4BUY4	DNA-3-methyladenine glycosylase II		167	Unreviewed		base-excision repair	alkylbase DNA N-glycosylase activity | DNA binding		DNA damage | DNA repair | Hydrolase | Reference proteome		Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions
Hyalomma marginatum	34627	A0A8S4BUX9	Transaldolase		216	Unreviewed	Cytoplasm	carbohydrate metabolic process | pentose-phosphate shunt	aldehyde-lyase activity | transaldolase activity	cytoplasm	Cytoplasm | Pentose shunt | Reference proteome | Schiff base | Transferase		Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate
Hyalomma marginatum	34627	A0A8S4BUX2	3-deoxy-8-phosphooctulonate synthase		278	Unreviewed	Cytoplasm		3-deoxy-8-phosphooctulonate synthase activity	cytoplasm	Cytoplasm | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BUR5	Pyruvate dehydrogenase E1 component subunit beta		332	Unreviewed		pyruvate decarboxylation to acetyl-CoA	pyruvate dehydrogenase (acetyl-transferring) activity		Oxidoreductase | Pyruvate | Reference proteome | Thiamine pyrophosphate		The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2
Hyalomma marginatum	34627	A0A8S4BUB5	Phenylalanine--tRNA ligase alpha subunit		341	Unreviewed	Cytoplasm	phenylalanyl-tRNA aminoacylation	ATP binding | metal ion binding | phenylalanine-tRNA ligase activity | tRNA binding	cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Cytoplasm | Ligase | Magnesium | Metal-binding | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BU18	Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial		177	Unreviewed		aerobic respiration | electron transport coupled proton transport	4 iron, 4 sulfur cluster binding | metal ion binding | NADH dehydrogenase (ubiquinone) activity | quinone binding	respiratory chain complex I	4Fe-4S | Iron | Iron-sulfur | Metal-binding | NAD | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BTX7	Small ribosomal subunit protein uS13		125	Unreviewed		translation	rRNA binding | structural constituent of ribosome	cytosol | small ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein | RNA-binding | rRNA-binding		
Hyalomma marginatum	34627	A0A8S4BTP9	Serine protease HTRA2, mitochondrial		497	Unreviewed	Mitochondrion intermembrane space | Mitochondrion membrane	apoptotic process | proteolysis	serine-type endopeptidase activity	mitochondrial intermembrane space | mitochondrial membrane	Apoptosis | Hydrolase | Protease | Reference proteome | Signal | Transit peptide | Zymogen		Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th/Diap1 by directly inducing the degradation of th/Diap1
Hyalomma marginatum	34627	A0A8S4BTK4	3-oxoacyl-[acyl-carrier-protein] reductase		245	Unreviewed		fatty acid biosynthetic process	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity | NAD binding		NADP | Oxidoreductase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BVC9	CTP synthase		549	Unreviewed		'de novo' CTP biosynthetic process | pyrimidine nucleobase biosynthetic process	ATP binding | CTP synthase activity | identical protein binding | metal ion binding	cytoophidium | cytosol	ATP-binding | Glutamine amidotransferase | Ligase | Magnesium | Metal-binding | Nucleotide-binding | Pyrimidine biosynthesis | Reference proteome		Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen
Hyalomma marginatum	34627	A0A8S4BVT9	Large ribosomal subunit protein uL30m		130	Unreviewed		translation	structural constituent of ribosome	large ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein		
Hyalomma marginatum	34627	A0A240EVU0	Histone H3	H3	89	Unreviewed			DNA binding | protein heterodimerization activity | structural constituent of chromatin	nucleosome	Chromosome | DNA-binding | Nucleosome core | Nucleus		
Hyalomma marginatum	34627	A0A0U3DLM1	Cytochrome c oxidase subunit 1		228	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A8F1A9D3	Cytochrome c oxidase subunit 1	COX1	93	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A889ZE67	Cytochrome c oxidase subunit 1	COX1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A7T0KCC1	Cytochrome c oxidase subunit 1	COX1	234	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A7L5TA68	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A6M5E699	Cytochrome c oxidase subunit 1	CO1	125	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A6M5E1A7	Cytochrome c oxidase subunit 1	CO1	124	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A6G9DT06	Cytochrome c oxidase subunit 1	COX1	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A6C0RJV6	Cytochrome c oxidase subunit 1	COI	248	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A4D6G324	Cytochrome c oxidase subunit 1		246	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A411N1G3	Cytochrome c oxidase subunit 1	COI	121	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A410UE80	Cytochrome c oxidase subunit 1	COI	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A2I7YUG8	Cytochrome c oxidase subunit 1	COI	138	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A240EVL2	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A1Q1N6E6	Cytochrome c oxidase subunit 1	COI	289	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A1Q1N6E4	Cytochrome c oxidase subunit 1	COI	289	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A1Q1N6E2	Cytochrome c oxidase subunit 1	COI	268	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A1Q1N603	Cytochrome c oxidase subunit 1	COI	285	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A1Q1N602	Cytochrome c oxidase subunit 1	COI	287	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A1Q1N5W5	Cytochrome c oxidase subunit 1	COI	277	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A1Q1N5R8	Cytochrome c oxidase subunit 1	COI	280	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A1Q1N5R7	Cytochrome c oxidase subunit 1	COI	279	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A0U2EQV2	Cytochrome c oxidase subunit 1	COI	153	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A0U2DGP3	Cytochrome c oxidase subunit 1	COI	153	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A0U2DBU9	Cytochrome c oxidase subunit 1	COI	153	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A0U2DBU3	Cytochrome c oxidase subunit 1	COI	153	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A0U2DB40	Cytochrome c oxidase subunit 1	COI	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A8S4C289	DNA polymerase III subunit epsilon		225	Unreviewed		DNA replication proofreading	3'-5' exonuclease activity | DNA binding | DNA-directed DNA polymerase activity | metal ion binding	cytosol	DNA replication | DNA-directed DNA polymerase | Exonuclease | Hydrolase | Magnesium | Manganese | Metal-binding | Nuclease | Nucleotidyltransferase | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8K1I3N2	Cytochrome c oxidase subunit 1	COX1	257	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A8S4BUW3	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial		597	Unreviewed	Membrane | Mitochondrion inner membrane	mitochondrial electron transport, succinate to ubiquinone | tricarboxylic acid cycle	electron transfer activity | flavin adenine dinucleotide binding | succinate dehydrogenase (quinone) activity	mitochondrial inner membrane	Electron transport | FAD | Flavoprotein | Membrane | Oxidoreductase | Reference proteome | Transit peptide | Transport | Tricarboxylic acid cycle		Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)
Hyalomma marginatum	34627	A0A8S4BUY8	Cytochrome c oxidase subunit III		281	Unreviewed	Cell inner membrane | Plastid, chloroplast thylakoid lumen	proton transmembrane transport	electron transfer activity | heme binding | iron ion binding | oxidoreductase activity	plasma membrane	Cell inner membrane | Cell membrane | Electron transport | Heme | Hydrogen ion transport | Ion transport | Iron | Membrane | Metal-binding | Oxidoreductase | Reference proteome | Repeat | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
Hyalomma marginatum	34627	A0A8S4BV96	5-demethoxyubiquinone hydroxylase, mitochondrial		170	Unreviewed	Mitochondrion inner membrane	determination of adult lifespan | regulation of gene expression | regulation of reactive oxygen species metabolic process | ubiquinone biosynthetic process	3-demethoxyubiquinol 3-hydroxylase activity | metal ion binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	extrinsic component of mitochondrial inner membrane | nucleus	Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Monooxygenase | Oxidoreductase | Reference proteome | Ubiquinone biosynthesis		Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner
Hyalomma marginatum	34627	A0A0U3DKF9	Cytochrome c oxidase subunit 1		231	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A0U3CDW8	Cytochrome c oxidase subunit 1		230	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A0U3CAD6	Cytochrome c oxidase subunit 1		239	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	Q8HE90	Cytochrome c oxidase subunit 1	COI	248	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	Q8HE89	Cytochrome c oxidase subunit 1	COI	264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	Q8HE88	Cytochrome c oxidase subunit 1	COI	264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	Q8HAW2	Cytochrome c oxidase subunit 1	COI	264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	C6F0C1	Cytochrome c oxidase subunit 1	COI	286	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	C6F0C0	Cytochrome c oxidase subunit 1	COI	286	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A8S4C4K6	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial		388	Unreviewed	Mitochondrion	succinyl-CoA metabolic process | tricarboxylic acid cycle	ATP binding | magnesium ion binding | succinate-CoA ligase (ADP-forming) activity	cytosol | mitochondrion | succinate-CoA ligase complex	ATP-binding | Ligase | Magnesium | Metal-binding | Mitochondrion | Nucleotide-binding | Reference proteome | Tricarboxylic acid cycle		Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
Hyalomma marginatum	34627	A0A8S4C487	Serine--tRNA ligase		426	Unreviewed	Cytoplasm	seryl-tRNA aminoacylation	ATP binding | serine-tRNA ligase activity	cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Coiled coil | Cytoplasm | Ligase | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C3J0	Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial		485	Unreviewed	Mitochondrion	glutaminyl-tRNAGln biosynthesis via transamidation | mitochondrial translation	ATP binding | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	glutamyl-tRNA(Gln) amidotransferase complex | mitochondrion	ATP-binding | Ligase | Mitochondrion | Nucleotide-binding | Protein biosynthesis | Reference proteome		Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Hyalomma marginatum	34627	A0A8S4C2U8	4-hydroxy-2-oxoglutarate aldolase, mitochondrial		293	Unreviewed		diaminopimelate biosynthetic process | lysine biosynthetic process via diaminopimelate	(R,S)-4-hydroxy-2-oxoglutarate aldolase activity | 4-hydroxy-tetrahydrodipicolinate synthase activity	cytosol	Amino-acid biosynthesis | Cytoplasm | Diaminopimelate biosynthesis | Lyase | Lysine biosynthesis | Reference proteome | Schiff base		Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA)
Hyalomma marginatum	34627	A0A219YLY7	Cytochrome c oxidase subunit 1		245	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Hyalomma marginatum	34627	A0A8S4C2T4	Alanine--tRNA ligase		859	Unreviewed		alanyl-tRNA aminoacylation | negative regulation of DNA-templated transcription	alanine-tRNA ligase activity | aminoacyl-tRNA deacylase activity | ATP binding | tRNA binding | zinc ion binding	cytosol	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Metal-binding | Nucleotide-binding | Protein biosynthesis | Reference proteome | RNA-binding | tRNA-binding | Zinc		Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain
Hyalomma marginatum	34627	A0A8S4C2L9	4-hydroxybenzoate polyprenyltransferase, mitochondrial		324	Unreviewed	Membrane | Mitochondrion inner membrane	isoprenoid biosynthetic process | ubiquinone biosynthetic process	4-hydroxybenzoate polyprenyltransferase activity	mitochondrial inner membrane | plasma membrane	Isoprene biosynthesis | Membrane | Mitochondrion | Mitochondrion inner membrane | Reference proteome | Transferase | Transmembrane | Transmembrane helix | Ubiquinone biosynthesis		Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate
Hyalomma marginatum	34627	A0A8S4C2H9	Cytosol aminopeptidase		495	Unreviewed		proteolysis	manganese ion binding | metalloaminopeptidase activity	cytoplasm	Aminopeptidase | Hydrolase | Protease | Reference proteome		Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status
Hyalomma marginatum	34627	A0A8S4C1Q5	Probable periplasmic serine endoprotease DegP-like		496	Unreviewed	Mitochondrion intermembrane space | Mitochondrion membrane | Periplasm	apoptotic process | proteolysis	serine-type endopeptidase activity	mitochondrial intermembrane space | mitochondrial membrane	Apoptosis | Hydrolase | Periplasm | Protease | Reference proteome | Repeat | Serine protease | Signal | Stress response | Transit peptide | Zymogen		Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th/Diap1 by directly inducing the degradation of th/Diap1
Hyalomma marginatum	34627	A0A8S4C1L4	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex		390	Unreviewed		L-lysine catabolic process to acetyl-CoA via saccharopine | tricarboxylic acid cycle	dihydrolipoyllysine-residue succinyltransferase activity	cytosol | oxoglutarate dehydrogenase complex	Acyltransferase | Lipoyl | Pyruvate | Reference proteome | Transferase | Transit peptide | Tricarboxylic acid cycle		Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A
Hyalomma marginatum	34627	A0A8S4C1B1	glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating)		340	Unreviewed		glucose metabolic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity | NAD binding | NADP binding		NAD | Nucleotide-binding | Oxidoreductase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C0Y4	Cytochrome b		406	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Reference proteome | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Hyalomma marginatum	34627	A0A8S4C0W0	Queuine tRNA-ribosyltransferase catalytic subunit 1		353	Unreviewed	Cytoplasm	tRNA wobble guanine modification	metal ion binding | tRNA-guanosine(34) queuine transglycosylase activity	cytoplasm	Cytoplasm | Glycosyltransferase | Metal-binding | Reference proteome | Transferase | tRNA processing | Zinc		Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product
Hyalomma marginatum	34627	A0A8S4C0H1	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial		291	Unreviewed	Mitochondrion	tricarboxylic acid cycle	nucleotide binding | succinate-CoA ligase (ADP-forming) activity | succinate-CoA ligase (GDP-forming) activity	mitochondrion | succinate-CoA ligase complex (ADP-forming)	Ligase | Mitochondrion | Nucleotide-binding | Reference proteome | Tricarboxylic acid cycle		Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits
Hyalomma marginatum	34627	A0A8S4C0C0	Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial		453	Unreviewed	Cytoplasm	glutamyl-tRNA aminoacylation	ATP binding | glutamate-tRNA ligase activity | glutamate-tRNA(Gln) ligase activity | tRNA binding | zinc ion binding	cytosol	Aminoacyl-tRNA synthetase | ATP-binding | Cytoplasm | Ligase | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C0A6	Glycerol-3-phosphate dehydrogenase [NAD(+)]		330	Unreviewed		carbohydrate metabolic process | glycerol-3-phosphate catabolic process	glycerol-3-phosphate dehydrogenase (NAD+) activity | NAD binding	cytosol	Membrane | NAD | Oxidoreductase | Reference proteome | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BXN8	branched-chain-amino-acid transaminase		291	Unreviewed		amino acid biosynthetic process | branched-chain amino acid biosynthetic process	branched-chain-amino-acid transaminase activity		Amino-acid biosynthesis | Aminotransferase | Branched-chain amino acid biosynthesis | Pyridoxal phosphate | Reference proteome | Transferase		Acts on leucine, isoleucine and valine
Hyalomma marginatum	34627	A0A8S4BWZ8	Ubiquinone biosynthesis O-methyltransferase, mitochondrial		241	Unreviewed	Mitochondrion inner membrane	methylation	3-demethylubiquinol 3-O-methyltransferase activity | metal ion binding | polyprenyldihydroxybenzoate methyltransferase activity	extrinsic component of mitochondrial inner membrane	Magnesium | Membrane | Metal-binding | Methyltransferase | Mitochondrion | Mitochondrion inner membrane | Reference proteome | S-adenosyl-L-methionine | Transferase | Ubiquinone biosynthesis		O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol
Hyalomma marginatum	34627	A0A8S4BW88	Isocitrate dehydrogenase [NADP]		479	Unreviewed		glyoxylate cycle | isocitrate metabolic process | tricarboxylic acid cycle	isocitrate dehydrogenase (NAD+) activity | isocitrate dehydrogenase (NADP+) activity | magnesium ion binding | NAD binding	mitochondrion	Glyoxylate bypass | Magnesium | Manganese | Metal-binding | NADP | Oxidoreductase | Reference proteome | Tricarboxylic acid cycle		Catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate and carbon dioxide with the concomitant reduction of NADP(+)
Hyalomma marginatum	34627	A0A8S4C2P2	Cytochrome b-c1 complex subunit Rieske, mitochondrial	petA	184	Unreviewed	Cell membrane | Mitochondrion inner membrane		2 iron, 2 sulfur cluster binding | metal ion binding | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | plasma membrane	2Fe-2S | Cell membrane | Disulfide bond | Electron transport | Iron | Iron-sulfur | Membrane | Metal-binding | Mitochondrion | Reference proteome | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Hyalomma marginatum	34627	A0A8S4BVV2	Large ribosomal subunit protein uL29		68	Unreviewed		translation	structural constituent of ribosome	cytosolic large ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein		
Hyalomma marginatum	34627	A0A8S4BVF4	NADH:ubiquinone reductase (H(+)-translocating)		490	Unreviewed	Membrane	ATP synthesis coupled electron transport	NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Reference proteome | Transmembrane | Transmembrane helix		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A8S4BW02	N-acetylmuramoyl-L-alanine amidase		325	Unreviewed		cell wall organization | peptidoglycan catabolic process | peptidoglycan turnover	metallopeptidase activity | N-acetylmuramoyl-L-alanine amidase activity		Cell wall biogenesis/degradation | Hydrolase | Metalloprotease | Protease | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C1K6	Nucleoside diphosphate kinase		144	Unreviewed		CTP biosynthetic process | GTP biosynthetic process | UTP biosynthetic process	ATP binding | metal ion binding | nucleoside diphosphate kinase activity		ATP-binding | Cytoplasm | Kinase | Magnesium | Metal-binding | Nucleotide metabolism | Nucleotide-binding | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C1J7	6,7-dimethyl-8-ribityllumazine synthase		148	Unreviewed		riboflavin biosynthetic process	6,7-dimethyl-8-ribityllumazine synthase activity	riboflavin synthase complex	Reference proteome | Riboflavin biosynthesis | Transferase		Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
Hyalomma marginatum	34627	A0A8S4C1J3	NADH-ubiquinone oxidoreductase chain 4L		108	Unreviewed	Membrane	ATP synthesis coupled electron transport	NADH dehydrogenase (ubiquinone) activity | oxidoreductase activity, acting on NAD(P)H	NADH dehydrogenase complex	Membrane | NAD | Reference proteome | Translocase | Transmembrane | Transmembrane helix | Transport		
Hyalomma marginatum	34627	A0A8S4C1I3	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial		434	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	4 iron, 4 sulfur cluster binding | FMN binding | metal ion binding | NAD binding | NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	4Fe-4S | Electron transport | Flavoprotein | FMN | Iron | Iron-sulfur | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | NAD | Reference proteome | Respiratory chain | Transit peptide | Translocase | Transport		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I
Hyalomma marginatum	34627	A0A8S4C1G2	Cytochrome c family protein		185	Unreviewed	Mitochondrion intermembrane space		electron transfer activity | heme binding | metal ion binding	mitochondrial intermembrane space	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Reference proteome | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
Hyalomma marginatum	34627	A0A8S4C1F8	Malic enzyme		743	Unreviewed		malate metabolic process	acyltransferase activity | malic enzyme activity | metal ion binding | NAD binding | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		Metal-binding | Multifunctional enzyme | Oxidoreductase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C1F4	2-oxoglutarate dehydrogenase, mitochondrial		936	Unreviewed		tricarboxylic acid cycle	oxoglutarate dehydrogenase (succinyl-transferring) activity | thiamine pyrophosphate binding	cytosol | oxoglutarate dehydrogenase complex	Oxidoreductase | Reference proteome | Thiamine pyrophosphate | Transit peptide		The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
Hyalomma marginatum	34627	A0A8S4C1E9	histidine kinase		435	Unreviewed	Cell inner membrane		ATP binding | phosphorelay sensor kinase activity	plasma membrane	ATP-binding | Cell inner membrane | Cell membrane | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Reference proteome | Transferase | Transmembrane | Transmembrane helix | Two-component regulatory system		
Hyalomma marginatum	34627	A0A8S4C1E2	Triosephosphate isomerase		230	Unreviewed		gluconeogenesis | glyceraldehyde-3-phosphate biosynthetic process | glycerol catabolic process | glycolytic process	triose-phosphate isomerase activity	cytosol	Gluconeogenesis | Glycolysis | Isomerase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C1D8	DNA replication and repair protein RecF		351	Unreviewed	Cytoplasm	DNA replication | DNA synthesis involved in DNA repair | double-strand break repair	ATP binding | single-stranded DNA binding	cytoplasm	ATP-binding | Cytoplasm | DNA replication | DNA-binding | Nucleotide-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C1D1	DNA gyrase subunit B		810	Unreviewed		DNA topological change	ATP binding | DNA binding | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | metal ion binding	chromosome	ATP-binding | Cytoplasm | DNA-binding | Isomerase | Magnesium | Metal-binding | Nucleotide-binding | Reference proteome | Topoisomerase | Transit peptide		A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner
Hyalomma marginatum	34627	A0A8S4C197	Pseudouridine synthase		320	Unreviewed		pseudouridine synthesis	pseudouridine synthase activity | RNA binding		Isomerase | Reference proteome | RNA-binding		Responsible for synthesis of pseudouridine from uracil
Hyalomma marginatum	34627	A0A8S4C193	Rho RNA-BD domain-containing protein		529	Unreviewed		DNA-templated transcription termination	ATP binding | ATP-dependent activity, acting on RNA | helicase activity | hydrolase activity | RNA binding		ATP-binding | Helicase | Hydrolase | Nucleotide-binding | Reference proteome | RNA-binding | Transcription | Transcription regulation | Transcription termination		
Hyalomma marginatum	34627	A0A8S4C192	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial		682	Unreviewed		ATP synthesis coupled electron transport	4 iron, 4 sulfur cluster binding | metal ion binding | NADH dehydrogenase (ubiquinone) activity | oxidoreductase activity, acting on NAD(P)H	mitochondrial inner membrane | respiratory chain complex I	4Fe-4S | Iron | Iron-sulfur | Metal-binding | NAD | Reference proteome | Translocase		
Hyalomma marginatum	34627	A0A8S4C188	6-pyruvoyltetrahydropterin synthase		141	Unreviewed		tetrahydrobiopterin biosynthetic process	6-pyruvoyltetrahydropterin synthase activity | metal ion binding		Lyase | Metal-binding | Reference proteome | Tetrahydrobiopterin biosynthesis | Zinc		
Hyalomma marginatum	34627	A0A8S4C187	propionyl-CoA carboxylase		665	Unreviewed		lipid catabolic process	ATP binding | metal ion binding | propionyl-CoA carboxylase activity	mitochondrion	ATP-binding | Biotin | Ligase | Lipid degradation | Lipid metabolism | Magnesium | Manganese | Metal-binding | Nucleotide-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C171	DNA-directed DNA polymerase		530	Unreviewed		DNA-templated DNA replication	ATP binding | DNA binding | DNA-directed DNA polymerase activity | metal ion binding	DNA polymerase III complex	ATP-binding | DNA replication | DNA-directed DNA polymerase | Metal-binding | Nucleotide-binding | Nucleotidyltransferase | Reference proteome | Transferase | Zinc		
Hyalomma marginatum	34627	A0A8S4C156	Delta-aminolevulinic acid dehydratase		307	Unreviewed		heme biosynthetic process	porphobilinogen synthase activity | zinc ion binding	cytosol	Heme biosynthesis | Lyase | Porphyrin biosynthesis | Reference proteome		Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen
Hyalomma marginatum	34627	A0A8S4BVW6	tRNA-specific adenosine deaminase 2		149	Unreviewed		tRNA wobble adenosine to inosine editing	tRNA-specific adenosine-34 deaminase activity | zinc ion binding		Hydrolase | Metal-binding | Reference proteome | tRNA processing | Zinc		
Hyalomma marginatum	34627	A0A8S4C147	Large ribosomal subunit protein uL2		275	Unreviewed		mitochondrial translation	RNA binding | structural constituent of ribosome | transferase activity	mitochondrial large ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein		
Hyalomma marginatum	34627	A0A8S4C129	Aspartokinase		403	Unreviewed		homoserine biosynthetic process | lysine biosynthetic process via diaminopimelate	aspartate kinase activity | ATP binding	cytosol	Amino-acid biosynthesis | ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C123	DNA-directed RNA polymerase subunit beta		1371	Unreviewed		DNA-templated transcription	DNA binding | DNA-directed RNA polymerase activity | ribonucleoside binding	DNA-directed RNA polymerase complex	DNA-directed RNA polymerase | Nucleotidyltransferase | Reference proteome | Transcription | Transferase		DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Hyalomma marginatum	34627	A0A8S4C106	Amino acid transporter		405	Unreviewed	Cell membrane | Membrane	dicarboxylic acid transport	symporter activity	plasma membrane	Cell membrane | Membrane | Reference proteome | Symport | Transmembrane | Transmembrane helix | Transport		
Hyalomma marginatum	34627	A0A8S4C0Z1	DNA-directed DNA polymerase		383	Unreviewed		DNA-templated DNA replication | double-strand break repair	DNA binding | DNA-directed DNA polymerase activity		DNA damage | DNA repair | DNA replication | DNA-binding | DNA-directed DNA polymerase | Nucleotidyltransferase | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C0X4	Nucleotide exchange factor GrpE		183	Unreviewed	Cytoplasm	protein folding | protein import into mitochondrial matrix	adenyl-nucleotide exchange factor activity | protein homodimerization activity | protein-folding chaperone binding | unfolded protein binding	PAM complex, Tim23 associated import motor	Chaperone | Cytoplasm | Reference proteome | Stress response		
Hyalomma marginatum	34627	A0A8S4C0W6	8-amino-7-oxononanoate synthase		378	Unreviewed		biotin biosynthetic process	8-amino-7-oxononanoate synthase activity | pyridoxal phosphate binding | transaminase activity		Acyltransferase | Aminotransferase | Biotin biosynthesis | Pyridoxal phosphate | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C0T8	Bifunctional DNA-formamidopyrimidine glycosylase/DNA-(Apurinic or apyrimidinic site) lyase		269	Unreviewed		base-excision repair	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity | class I DNA-(apurinic or apyrimidinic site) endonuclease activity | damaged DNA binding | zinc ion binding		DNA damage | DNA repair | DNA-binding | Glycosidase | Hydrolase | Lyase | Metal-binding | Multifunctional enzyme | Reference proteome | Zinc | Zinc-finger		
Hyalomma marginatum	34627	A0A8S4C1M2	Large ribosomal subunit protein bL17c		139	Unreviewed		translation	structural constituent of ribosome	cytosolic large ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein		
Hyalomma marginatum	34627	A0A8S4C1N4	Pyruvate dehydrogenase E1 component subunit alpha		331	Unreviewed		pyruvate decarboxylation to acetyl-CoA	pyruvate dehydrogenase (acetyl-transferring) activity		Oxidoreductase | Pyruvate | Reference proteome | Thiamine pyrophosphate | Transit peptide		The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Hyalomma marginatum	34627	A0A8S4C1P3	UDP-N-acetylmuramate--L-alanine ligase		487	Unreviewed	Cytoplasm		ATP binding | UDP-N-acetylmuramate-L-alanine ligase activity	cytoplasm	ATP-binding | Cytoplasm | Ligase | Nucleotide-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C1P6	Large ribosomal subunit protein uL22c		120	Unreviewed		translation	rRNA binding | structural constituent of ribosome	cytosolic large ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein | RNA-binding | rRNA-binding		
Hyalomma marginatum	34627	A0A8S4C256	Ribonuclease G		657	Unreviewed	Cytoplasm	rRNA processing | tRNA processing	endonuclease activity | hydrolase activity | metal ion binding | RNA nuclease activity | rRNA binding	cytoplasm	Cell inner membrane | Cell membrane | Cytoplasm | Endonuclease | Hydrolase | Magnesium | Membrane | Metal-binding | Nuclease | Reference proteome | RNA-binding | rRNA processing | rRNA-binding | tRNA processing		Involved in intercistronic processing of primary transcripts from chloroplast operons. The endonucleolytic activity of the enzyme depends on the number of phosphates at the 5' end, is inhibited by structured RNA, and preferentially cleaves A/U-rich sequences
Hyalomma marginatum	34627	A0A8S4C253	Complex I-49kD		391	Unreviewed		mitochondrial electron transport, NADH to ubiquinone	NAD binding | oxidoreductase activity, acting on NAD(P)H | quinone binding	mitochondrion	NAD | Reference proteome | Translocase | Transport		
Hyalomma marginatum	34627	A0A8S4C238	N-acetylaspartylglutamate synthase		173	Unreviewed		translation	ATP binding | metal ion binding | ribosomal S6-glutamic acid ligase activity	cytoplasm	ATP-binding | Ligase | Magnesium | Manganese | Metal-binding | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C235	Metalloendopeptidase OMA1, mitochondrial		194	Unreviewed		proteolysis involved in protein catabolic process	metal ion binding | metalloendopeptidase activity	membrane	Hydrolase | Metal-binding | Metalloprotease | Protease | Reference proteome | Signal | Zinc		
Hyalomma marginatum	34627	A0A8S4C232	Probable protein-export membrane protein SecG		100	Unreviewed	Cell membrane	intracellular protein transmembrane transport | protein secretion	protein-transporting ATPase activity	plasma membrane	Cell membrane | Membrane | Protein transport | Reference proteome | Signal | Translocation | Transmembrane | Transmembrane helix | Transport		Involved in protein export. Participates in an early event of protein translocation across the chloroplast thylakoid membrane
Hyalomma marginatum	34627	A0A8S4C219	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	168	Unreviewed		terpenoid biosynthetic process	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity		Isoprene biosynthesis | Lyase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C212	Large ribosomal subunit protein bL21m		99	Unreviewed		translation	RNA binding | structural constituent of ribosome	cytoplasm | ribonucleoprotein complex | ribosome	Reference proteome | Ribonucleoprotein | Ribosomal protein		
Hyalomma marginatum	34627	A0A8S4C211	Putative GTP diphosphokinase RSH1, chloroplastic		736	Unreviewed		guanosine tetraphosphate metabolic process | response to starvation	GTP diphosphokinase activity | guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	plasma membrane	Reference proteome		
Hyalomma marginatum	34627	A0A8S4C202	tRNA (guanine-N(1)-)-methyltransferase		237	Unreviewed	Cytoplasm	tRNA N1-guanine methylation	tRNA (guanine(37)-N1)-methyltransferase activity	cytosol	Cytoplasm | Methyltransferase | Reference proteome | S-adenosyl-L-methionine | Signal | Transferase | tRNA processing		Specifically methylates guanosine-37 in various tRNAs
Hyalomma marginatum	34627	A0A8S4C201	Thioredoxin		107	Unreviewed			protein-disulfide reductase activity	cytoplasm	Disulfide bond | Electron transport | Redox-active center | Reference proteome | Transport		
Hyalomma marginatum	34627	A0A8S4C1Z3	L-Fucosyltransferase		649	Unreviewed	Golgi apparatus, Golgi stack membrane	carbohydrate metabolic process	galactoside 2-alpha-L-fucosyltransferase activity	Golgi cisterna membrane	Glycoprotein | Glycosyltransferase | Golgi apparatus | Membrane | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4C1Y1	Deoxyuridine 5'-triphosphate nucleotidohydrolase		151	Unreviewed		dUMP biosynthetic process | dUTP catabolic process	dUTP diphosphatase activity | magnesium ion binding		Hydrolase | Magnesium | Metal-binding | Nucleotide metabolism | Reference proteome		Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
Hyalomma marginatum	34627	A0A8S4C1W9	isoleucine--tRNA ligase		1048	Unreviewed		isoleucyl-tRNA aminoacylation	aminoacyl-tRNA deacylase activity | ATP binding | isoleucine-tRNA ligase activity | metal ion binding | tRNA binding		Aminoacyl-tRNA synthetase | ATP-binding | Cytoplasm | Ligase | Metal-binding | Nucleotide-binding | Protein biosynthesis | Reference proteome | Zinc		
Hyalomma marginatum	34627	A0A8S4C0Q7	Purine nucleoside phosphorylase		246	Unreviewed			copper ion binding | hydrolase activity | S-methyl-5-thioadenosine phosphorylase activity		Hydrolase | Metal-binding | Reference proteome | Transferase | Zinc		
Hyalomma marginatum	34627	A0A8S4C1W5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12		118	Unreviewed	Mitochondrion inner membrane	response to oxidative stress		mitochondrial inner membrane | respiratory chain complex I	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | Reference proteome | Respiratory chain | Transport		Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A8S4C1V9	Heat shock protein 83	htpG	621	Unreviewed			ATP binding | ATP hydrolysis activity | ATP-dependent protein folding chaperone | unfolded protein binding		ATP-binding | Chaperone | Nucleotide-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C1V5	ATP-dependent Clp protease ATP-binding subunit ClpX		416	Unreviewed		cell division | proteolysis involved in protein catabolic process	ATP binding | ATP hydrolysis activity | ATP-dependent protein folding chaperone | peptidase activity | protein dimerization activity | unfolded protein binding | zinc ion binding	HslUV protease complex	ATP-binding | Chaperone | Hydrolase | Metal-binding | Nucleotide-binding | Protease | Reference proteome | Zinc		
Hyalomma marginatum	34627	A0A8S4C1V2	Small ribosomal subunit protein bS1		569	Unreviewed		translation	mRNA binding | structural constituent of ribosome	cytosolic small ribosomal subunit	Reference proteome | Repeat | Ribonucleoprotein | Ribosomal protein | RNA-binding		Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Hyalomma marginatum	34627	A0A8S4C1V0	glycine--tRNA ligase		281	Unreviewed		glycyl-tRNA aminoacylation	ATP binding | glycine-tRNA ligase activity	cytosol	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C1U9	Phenylalanine--tRNA ligase beta subunit		792	Unreviewed	Cytoplasm	phenylalanyl-tRNA aminoacylation	ATP binding | magnesium ion binding | phenylalanine-tRNA ligase activity | tRNA binding	phenylalanine-tRNA ligase complex	Aminoacyl-tRNA synthetase | ATP-binding | Cytoplasm | Ligase | Magnesium | Metal-binding | Nucleotide-binding | Protein biosynthesis | Reference proteome | RNA-binding | tRNA-binding		
Hyalomma marginatum	34627	A0A8S4C1U5	Phosphatidate cytidylyltransferase		156	Unreviewed	Cell membrane	CDP-diacylglycerol biosynthetic process	phosphatidate cytidylyltransferase activity	plasma membrane	Cell membrane | Lipid biosynthesis | Lipid metabolism | Membrane | Nucleotidyltransferase | Phospholipid biosynthesis | Phospholipid metabolism | Reference proteome | Transferase | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4C1T9	Molecular chaperone DnaJ		385	Unreviewed	Cytoplasm	DNA replication | protein refolding | response to heat	ATP binding | heat shock protein binding | unfolded protein binding | zinc ion binding	cytoplasm	Chaperone | Cytoplasm | DNA replication | Metal-binding | Reference proteome | Repeat | Stress response | Zinc | Zinc-finger		
Hyalomma marginatum	34627	A0A8S4C1S8	ATP-dependent Clp protease proteolytic subunit		216	Unreviewed		protein quality control for misfolded or incompletely synthesized proteins	ATP-dependent peptidase activity | ATPase binding | serine-type endopeptidase activity	endopeptidase Clp complex	Cytoplasm | Hydrolase | Protease | Reference proteome | Serine protease		Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates
Hyalomma marginatum	34627	A0A8S4C1S2	tetrahydrofolate synthase		428	Unreviewed			ATP binding | dihydrofolate synthase activity | metal ion binding | tetrahydrofolylpolyglutamate synthase activity	cytoplasm	ATP-binding | Ligase | Magnesium | Metal-binding | Nucleotide-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C1R8	lipid IVA 3-deoxy-D-manno-octulosonic acid transferase		421	Unreviewed		lipid A biosynthetic process	Kdo transferase activity	plasma membrane	Membrane | Reference proteome | Transferase | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4C1R7	Translation initiation factor IF-2, chloroplastic		881	Unreviewed			GTP binding | GTPase activity | translation initiation factor activity	cytoplasm	GTP-binding | Initiation factor | Nucleotide-binding | Protein biosynthesis | Reference proteome		One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Hyalomma marginatum	34627	A0A8S4C1R4	Succinate dehydrogenase, hydrophobic membrane anchor protein		123	Unreviewed	Cell inner membrane	cytochrome complex assembly | tricarboxylic acid cycle	electron transfer activity | heme binding | metal ion binding	plasma membrane	Cell inner membrane | Cell membrane | Electron transport | Heme | Iron | Membrane | Metal-binding | Reference proteome | Transmembrane | Transmembrane helix | Transport | Tricarboxylic acid cycle		Membrane-anchoring subunit of succinate dehydrogenase (SDH)
Hyalomma marginatum	34627	A0A8S4C1Q8	thioredoxin-dependent peroxiredoxin		152	Unreviewed		cell redox homeostasis | cellular response to oxidative stress	thioredoxin peroxidase activity	cytoplasm	Antioxidant | Disulfide bond | Oxidoreductase | Peroxidase | Redox-active center | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C1W0	1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic		385	Unreviewed		isoprenoid biosynthetic process	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity | manganese ion binding | NADPH binding		Isoprene biosynthesis | Manganese | Metal-binding | NADP | Oxidoreductase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C0Q4	Peptide deformylase		173	Unreviewed		translation	metal ion binding | peptide deformylase activity		Hydrolase | Metal-binding | Protein biosynthesis | Reference proteome		Removes the formyl group from the N-terminal Met of newly synthesized proteins
Hyalomma marginatum	34627	A0A8S4C155	3-hydroxyacyl-[acyl-carrier-protein] dehydratase		150	Unreviewed	Cytoplasm	fatty acid biosynthetic process | lipid A biosynthetic process	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	cytoplasm | membrane	Cytoplasm | Lipid A biosynthesis | Lipid biosynthesis | Lipid metabolism | Lyase | Reference proteome		Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
Hyalomma marginatum	34627	A0A8S4C0M3	Nicotinamide-nucleotide adenylyltransferase		318	Unreviewed		NAD+ biosynthetic process	ATP binding | nicotinamide-nucleotide adenylyltransferase activity | nicotinate-nucleotide adenylyltransferase activity		ATP-binding | NAD | Nucleotide-binding | Nucleotidyltransferase | Pyridine nucleotide biosynthesis | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BXV0	(d)CMP kinase		208	Unreviewed		nucleobase-containing compound metabolic process	ATP binding | dCMP kinase activity		ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BXQ3	Type-4 uracil-DNA glycosylase		262	Unreviewed		DNA repair	4 iron, 4 sulfur cluster binding | metal ion binding | uracil DNA N-glycosylase activity		4Fe-4S | DNA damage | DNA repair | Hydrolase | Iron | Iron-sulfur | Metal-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BXL7	Pyruvate, phosphate dikinase		876	Unreviewed			ATP binding | kinase activity | metal ion binding | pyruvate, phosphate dikinase activity		ATP-binding | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Pyruvate | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BXK9	peptidoglycan glycosyltransferase		393	Unreviewed	Membrane	cell division | regulation of cell shape	lipid-linked peptidoglycan transporter activity | peptidoglycan glycosyltransferase activity	cell division site | plasma membrane	Cell cycle | Cell division | Cell shape | Glycosyltransferase | Membrane | Peptidoglycan synthesis | Reference proteome | Transferase | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BXI9	4-hydroxy-tetrahydrodipicolinate reductase		254	Unreviewed		diaminopimelate biosynthetic process | lysine biosynthetic process via diaminopimelate	4-hydroxy-tetrahydrodipicolinate reductase	cytosol	Amino-acid biosynthesis | Cytoplasm | Diaminopimelate biosynthesis | Lysine biosynthesis | NAD | NADP | Oxidoreductase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BXI5	Bifunctional riboflavin kinase/FMN adenylyltransferase		329	Unreviewed		FMN biosynthetic process | riboflavin biosynthetic process	ATP binding | FMN adenylyltransferase activity | riboflavin kinase activity		ATP-binding | FAD | Flavoprotein | FMN | Kinase | Multifunctional enzyme | Nucleotide-binding | Nucleotidyltransferase | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BXC2	peptidoglycan lytic exotransglycosylase		384	Unreviewed		cell wall organization | peptidoglycan catabolic process | peptidoglycan turnover	hydrolase activity, hydrolyzing O-glycosyl compounds | peptidoglycan lytic transglycosylase activity	outer membrane	Cell wall biogenesis/degradation | Lyase | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BX75	Ribonucleoside-diphosphate reductase		635	Unreviewed		deoxyribonucleotide biosynthetic process	ATP binding | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ribonucleoside-diphosphate reductase complex	Deoxyribonucleotide synthesis | Oxidoreductase | Reference proteome		Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Hyalomma marginatum	34627	A0A8S4C0N6	DNA-directed DNA polymerase		347	Unreviewed		DNA-templated DNA replication	DNA binding | DNA-directed DNA polymerase activity	DNA polymerase III complex	DNA replication | DNA-directed DNA polymerase | Nucleotidyltransferase | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BX05	Radical S-adenosyl methionine domain-containing protein 1, mitochondrial		380	Unreviewed		porphyrin-containing compound biosynthetic process	4 iron, 4 sulfur cluster binding | coproporphyrinogen oxidase activity | metal ion binding	mitochondrion	Chaperone | Heme | Iron | Iron-sulfur | Metal-binding | Reference proteome | S-adenosyl-L-methionine		May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine
Hyalomma marginatum	34627	A0A8S4BWW3	Large ribosomal subunit protein bL9m		173	Unreviewed		translation	rRNA binding | structural constituent of ribosome	ribonucleoprotein complex | ribosome	Coiled coil | Reference proteome | Ribonucleoprotein | Ribosomal protein | RNA-binding | rRNA-binding		
Hyalomma marginatum	34627	A0A8S4BWU4	dihydropteroate synthase		262	Unreviewed		folic acid biosynthetic process | tetrahydrofolate biosynthetic process	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity | dihydropteroate synthase activity | metal ion binding	cytosol	Folate biosynthesis | Magnesium | Metal-binding | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BWT8	ATP-dependent protease subunit HslV		175	Unreviewed	Cytoplasm	proteolysis involved in protein catabolic process	metal ion binding | threonine-type endopeptidase activity	HslUV protease complex | proteasome core complex	Cytoplasm | Hydrolase | Metal-binding | Protease | Reference proteome | Threonine protease		
Hyalomma marginatum	34627	A0A8S4BWT3	tetraacyldisaccharide 4'-kinase		347	Unreviewed		lipid A biosynthetic process	ATP binding | lipid-A 4'-kinase activity	plasma membrane	ATP-binding | Kinase | Lipid A biosynthesis | Lipid biosynthesis | Lipid metabolism | Membrane | Nucleotide-binding | Reference proteome | Transferase | Transmembrane | Transmembrane helix		
Hyalomma marginatum	34627	A0A8S4BWR5	threonine--tRNA ligase		639	Unreviewed		threonyl-tRNA aminoacylation	ATP binding | metal ion binding | threonine-tRNA ligase activity | tRNA binding	cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Cytoplasm | Ligase | Metal-binding | Nucleotide-binding | Protein biosynthesis | Reference proteome | RNA-binding | tRNA-binding | Zinc		
Hyalomma marginatum	34627	A0A8S4BWR2	UDP-N-acetylmuramate dehydrogenase		306	Unreviewed	Cytoplasm | Peroxisome	cell division | cell wall organization | regulation of cell shape	FAD binding | UDP-N-acetylmuramate dehydrogenase activity	cytosol | peroxisome	Cell cycle | Cell division | Cell shape | Cell wall biogenesis/degradation | Cytoplasm | FAD | Flavoprotein | NADP | Oxidoreductase | Peptidoglycan synthesis | Peroxisome | Reference proteome		Cell wall formation
Hyalomma marginatum	34627	A0A8S4BWL3	DNA ligase (NAD(+))		675	Unreviewed		DNA repair | DNA replication	DNA ligase (NAD+) activity | metal ion binding	cytosol	DNA damage | DNA repair | DNA replication | Ligase | Magnesium | Metal-binding | NAD | Reference proteome | Zinc		
Hyalomma marginatum	34627	A0A8S4BWL0	NADH-quinone oxidoreductase subunit NuoE		190	Unreviewed		mitochondrial electron transport, NADH to ubiquinone	2 iron, 2 sulfur cluster binding | metal ion binding | NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	catalytic complex | membrane protein complex | mitochondrial inner membrane	2Fe-2S | Iron | Iron-sulfur | Metal-binding | NAD | Reference proteome | Translocase		
Hyalomma marginatum	34627	A0A8S4BWJ1	ATP synthase F0 sector subunit C		75	Unreviewed	Membrane	proton motive force-driven ATP synthesis	lipid binding | proton transmembrane transporter activity	proton-transporting ATP synthase complex | proton-transporting two-sector ATPase complex, proton-transporting domain	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Lipid-binding | Membrane | Reference proteome | Transmembrane | Transmembrane helix | Transport		F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Hyalomma marginatum	34627	A0A8S4BWI4	Serine hydroxymethyltransferase		424	Unreviewed	Cytoplasm	glycine biosynthetic process from serine | tetrahydrofolate interconversion	glycine hydroxymethyltransferase activity | pyridoxal phosphate binding	cytosol	Cytoplasm | One-carbon metabolism | Pyridoxal phosphate | Reference proteome | Transferase		Interconversion of serine and glycine
Hyalomma marginatum	34627	A0A8S4BWE5	serine-type D-Ala-D-Ala carboxypeptidase		388	Unreviewed		cell wall organization | proteolysis | regulation of cell shape	serine-type D-Ala-D-Ala carboxypeptidase activity		Carboxypeptidase | Cell shape | Cell wall biogenesis/degradation | Hydrolase | Peptidoglycan synthesis | Protease | Reference proteome | Signal		Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
Hyalomma marginatum	34627	A0A8S4BWD6	Flagellum-specific ATP synthase		445	Unreviewed	Cytoplasm	protein secretion by the type III secretion system	ATP binding | ATP hydrolysis activity | protein-exporting ATPase activity | proton-transporting ATP synthase activity, rotational mechanism	cytoplasm	ATP synthesis | ATP-binding | Bacterial flagellum biogenesis | Bacterial flagellum protein export | Cell projection | Cilium | Cytoplasm | Flagellum | Hydrogen ion transport | Ion transport | Nucleotide-binding | Protein transport | Reference proteome | Translocase | Transport		Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum
Hyalomma marginatum	34627	A0A8S4BWB5	Type III pantothenate kinase		258	Unreviewed	Cytoplasm	coenzyme A biosynthetic process	ATP binding | pantothenate kinase activity	cytoplasm	ATP-binding | Coenzyme A biosynthesis | Cytoplasm | Kinase | Nucleotide-binding | Potassium | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BW78	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase		120	Unreviewed		fatty acid biosynthetic process	holo-[acyl-carrier-protein] synthase activity | magnesium ion binding		Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Magnesium | Metal-binding | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BW50	Methionine--tRNA ligase, mitochondrial		493	Unreviewed		methionyl-tRNA aminoacylation	ATP binding | metal ion binding | methionine-tRNA ligase activity		Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Metal-binding | Nucleotide-binding | Protein biosynthesis | Reference proteome | Zinc		
Hyalomma marginatum	34627	A0A8S4BW25	Enolase		412	Unreviewed		glycolytic process	magnesium ion binding | phosphopyruvate hydratase activity	phosphopyruvate hydratase complex	Glycolysis | Lyase | Magnesium | Metal-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BW10	histidine kinase		901	Unreviewed	Membrane	osmosensory signaling via phosphorelay pathway	ATP binding | phosphorelay response regulator activity | protein histidine kinase activity | protein kinase activator activity | transmembrane transporter activity	membrane	ATP-binding | Kinase | Membrane | Nucleotide-binding | Reference proteome | Transferase | Transmembrane | Transmembrane helix | Two-component regulatory system		
Hyalomma marginatum	34627	A0A8S4BXY5	Phosphoglycerate kinase		392	Unreviewed		gluconeogenesis | glycolytic process	ADP binding | ATP binding | phosphoglycerate kinase activity	cytosol	ATP-binding | Kinase | Magnesium | Nucleotide-binding | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BYA0	ATP synthase subunit beta		470	Unreviewed	Membrane		ATP binding | proton-transporting ATP synthase activity, rotational mechanism	proton-transporting ATP synthase complex	ATP synthesis | ATP-binding | CF(1) | Hydrogen ion transport | Ion transport | Membrane | Nucleotide-binding | Reference proteome | Translocase | Transport		Produces ATP from ADP in the presence of a proton gradient across the membrane
Hyalomma marginatum	34627	A0A8S4BX34	Citrate synthase		438	Unreviewed	Mitochondrion matrix	tricarboxylic acid cycle	acyltransferase activity, acyl groups converted into alkyl on transfer	mitochondrial matrix	Reference proteome | Transferase | Tricarboxylic acid cycle		
Hyalomma marginatum	34627	A0A8S4BZH9	Peptidyl-prolyl cis-trans isomerase	ppiA	211	Unreviewed		protein folding	peptidyl-prolyl cis-trans isomerase activity		Isomerase | Reference proteome | Rotamase | Signal		PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Hyalomma marginatum	34627	A0A8S4C0L2	GP-PDE domain-containing protein		292	Unreviewed		lipid metabolic process	lyase activity | metal ion binding | phosphoric diester hydrolase activity		Disulfide bond | Lyase | Magnesium | Metal-binding | Reference proteome | Signal		
Hyalomma marginatum	34627	A0A8S4C0K5	DNA 3'-5' helicase		646	Unreviewed		DNA recombination | DNA replication initiation | DNA replication, synthesis of primer | double-strand break repair	3'-5' DNA helicase activity | ATP binding | DNA binding | hydrolase activity | metal ion binding		ATP-binding | DNA replication | DNA-binding | Helicase | Hydrolase | Isomerase | Metal-binding | Nucleotide-binding | Primosome | Reference proteome | Zinc		
Hyalomma marginatum	34627	A0A8S4C0J9	tRNA pseudouridine(55) synthase		310	Unreviewed		mRNA pseudouridine synthesis | tRNA modification	RNA binding | tRNA pseudouridine(55) synthase activity		Isomerase | Reference proteome | tRNA processing		
Hyalomma marginatum	34627	A0A8S4BZF9	Ribonuclease		193	Unreviewed	Cytoplasm	DNA replication, removal of RNA primer | mismatch repair	metal ion binding | RNA binding | RNA-DNA hybrid ribonuclease activity	cytoplasm | ribonuclease H2 complex	Cytoplasm | Endonuclease | Hydrolase | Manganese | Metal-binding | Nuclease | Reference proteome		Endonuclease that specifically degrades the RNA of RNA-DNA hybrids
Hyalomma marginatum	34627	A0A8S4C0J2	coproporphyrinogen oxidase		276	Unreviewed		protoporphyrinogen IX biosynthetic process	coproporphyrinogen oxidase activity	cytoplasm	Oxidoreductase | Porphyrin biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C0I6	5-aminolevulinate synthase		411	Unreviewed		protoporphyrinogen IX biosynthetic process	5-aminolevulinate synthase activity | pyridoxal phosphate binding	mitochondrion	Acyltransferase | Heme biosynthesis | Pyridoxal phosphate | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C0I0	DNA 3'-5' helicase		728	Unreviewed		recombinational repair	3'-5' DNA helicase activity | ATP binding | DNA binding | hydrolase activity	cytosol | DNA helicase complex	ATP-binding | DNA-binding | Helicase | Hydrolase | Isomerase | Nucleotide-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C0H8	Uridylate kinase		234	Unreviewed	Cytoplasm	UDP biosynthetic process	ATP binding | UMP kinase activity	cytoplasm	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Pyrimidine biosynthesis | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C0G9	DNA-directed RNA polymerase		123	Unreviewed		DNA-templated transcription	DNA binding | DNA-directed RNA polymerase activity	DNA-directed RNA polymerase complex	DNA-directed RNA polymerase | Nucleotidyltransferase | Reference proteome | Transcription | Transferase		
Hyalomma marginatum	34627	A0A8S4C0E9	GTP cyclohydrolase 1		179	Unreviewed		one-carbon metabolic process | tetrahydrobiopterin biosynthetic process | tetrahydrofolate biosynthetic process	GTP binding | GTP cyclohydrolase I activity | zinc ion binding	cytoplasm	Hydrolase | One-carbon metabolism | Reference proteome | Tetrahydrobiopterin biosynthesis		
Hyalomma marginatum	34627	A0A8S4C0E4	Small ribosomal subunit protein uS17c		75	Unreviewed		translation	rRNA binding | structural constituent of ribosome	cytosolic small ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein | RNA-binding | rRNA-binding		One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Hyalomma marginatum	34627	A0A8S4C0D0	Large ribosomal subunit protein uL11		142	Unreviewed		translation	large ribosomal subunit rRNA binding | structural constituent of ribosome	cytosolic large ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein | RNA-binding | rRNA-binding		
Hyalomma marginatum	34627	A0A8S4C090	DNA topoisomerase		791	Unreviewed		DNA topological change	DNA binding | DNA topoisomerase type I (single strand cut, ATP-independent) activity | zinc ion binding	chromosome	DNA-binding | Isomerase | Magnesium | Metal-binding | Reference proteome | Topoisomerase | Zinc | Zinc-finger		
Hyalomma marginatum	34627	A0A8S4C071	Lysine--tRNA ligase		522	Unreviewed	Cytoplasm	lysyl-tRNA aminoacylation	ATP binding | lysine-tRNA ligase activity | tRNA binding	cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Cytoplasm | Ligase | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C0J8	dTMP kinase		205	Unreviewed		dTDP biosynthetic process | dTTP biosynthetic process | dUDP biosynthetic process	ATP binding | dTMP kinase activity	cytosol	ATP-binding | Kinase | Nucleotide biosynthesis | Nucleotide-binding | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4C051	4-hydroxy-3-methylbut-2-enyl diphosphate reductase		316	Unreviewed		dimethylallyl diphosphate biosynthetic process	4 iron, 4 sulfur cluster binding | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity | metal ion binding		4Fe-4S | Iron | Iron-sulfur | Metal-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C063	Protein translocase subunit SecA		867	Unreviewed	Cell membrane	intracellular protein transport | protein import | protein targeting | protein transmembrane transport	ATP binding | metal ion binding	cytosol | plasma membrane	ATP-binding | Cell membrane | Cytoplasm | Membrane | Metal-binding | Nucleotide-binding | Protein transport | Reference proteome | Translocase | Translocation | Transport | Zinc		
Hyalomma marginatum	34627	A0A8S4BZK9	rRNA adenine N(6)-methyltransferase		271	Unreviewed			RNA binding | rRNA (adenine-N6,N6-)-dimethyltransferase activity		Cytoplasm | Methyltransferase | Reference proteome | RNA-binding | rRNA processing | S-adenosyl-L-methionine | Transferase		Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome
Hyalomma marginatum	34627	A0A8S4BZN1	Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial		225	Unreviewed	Mitochondrion	protein lipoylation	lipoyl(octanoyl) transferase activity	mitochondrion	Acyltransferase | Mitochondrion | Reference proteome | Transferase		Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
Hyalomma marginatum	34627	A0A8S4BZW6	NADH-ubiquinone oxidoreductase chain 1		333	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | NAD | Reference proteome | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Hyalomma marginatum	34627	A0A8S4BZX6	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial		249	Unreviewed	Mitochondrion inner membrane	methylation	2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity	extrinsic component of mitochondrial inner membrane	Membrane | Methyltransferase | Mitochondrion | Mitochondrion inner membrane | Reference proteome | S-adenosyl-L-methionine | Transferase | Ubiquinone biosynthesis		Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Hyalomma marginatum	34627	A0A8S4BZY6	histidine--tRNA ligase		417	Unreviewed		histidyl-tRNA aminoacylation	ATP binding | histidine-tRNA ligase activity	cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Hyalomma marginatum	34627	A0A8S4BZV0	Small ribosomal subunit protein uS5c		177	Unreviewed		translation	rRNA binding | structural constituent of ribosome	cytoplasm | small ribosomal subunit	Reference proteome | Ribonucleoprotein | Ribosomal protein | RNA-binding | rRNA-binding		With S4 and S12 plays an important role in translational accuracy
Hyalomma marginatum	34627	A0A8S4C006	Alpha-latrotoxin		85	Unreviewed	Target cell membrane	exocytosis		host cell presynaptic membrane | other organism cell membrane	ANK repeat | Exocytosis | Membrane | Neurotoxin | Presynaptic neurotoxin | Reference proteome | Repeat | Target cell membrane | Target membrane | Toxin		
Hyalomma marginatum	34627	A0A8S4BZJ1	thioredoxin-dependent peroxiredoxin		199	Unreviewed	Cytoplasm	cell redox homeostasis | cellular response to stress | hydrogen peroxide catabolic process | response to oxidative stress	thioredoxin peroxidase activity	cytosol	Antioxidant | Cytoplasm | Disulfide bond | Oxidoreductase | Peroxidase | Redox-active center | Reference proteome		Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively
Hyalomma marginatum	34627	A0A8S4C008	phosphoglycerate mutase (2,3-diphosphoglycerate-independent)		499	Unreviewed		glucose catabolic process | glycolytic process	manganese ion binding | phosphoglycerate mutase activity	cytosol	Glycolysis | Isomerase | Manganese | Metal-binding | Reference proteome		
Hyalomma marginatum	34627	A0A8S4C015	DNA topoisomerase (ATP-hydrolyzing)		904	Unreviewed		DNA topological change	ATP binding | DNA binding | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	chromosome | cytoplasm | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	ATP-binding | DNA-binding | Isomerase | Nucleotide-binding | Reference proteome | Topoisomerase		
Hyalomma marginatum	34627	A0A8S4C047	UDP-N-acetylglucosamine 1-carboxyvinyltransferase		440	Unreviewed	Cytoplasm	cell division | cell wall organization | regulation of cell shape | UDP-N-acetylgalactosamine biosynthetic process	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity	cytoplasm	Cell cycle | Cell division | Cell shape | Cell wall biogenesis/degradation | Cytoplasm | Peptidoglycan synthesis | Reference proteome | Transferase		
Hyalomma marginatum	34627	A0A8S4BZZ6	Succinyl-diaminopimelate desuccinylase		381	Unreviewed		diaminopimelate biosynthetic process | L-arginine biosynthetic process | lysine biosynthetic process via diaminopimelate	acetylornithine deacetylase activity | metal ion binding | succinyl-diaminopimelate desuccinylase activity		Amino-acid biosynthesis | Diaminopimelate biosynthesis | Hydrolase | Lysine biosynthesis | Metal-binding | Reference proteome | Zinc		
Ixodes acutitarsus	59645	Q76FG7	Cytochrome c oxidase subunit 1	COI	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes acutitarsus	59645	A0A1B2FQD3	Cytochrome c oxidase subunit 1		209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes acutitarsus	59645	A0A1B2FQE6	Cytochrome c oxidase subunit 1		218	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes granulatus	59647	G3FSW9	Cytochrome c oxidase subunit 1	COI	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes granulatus	59647	Q0X071	Cytochrome c oxidase subunit 1	COI	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes granulatus	59647	I2B1G7	Cytochrome c oxidase subunit 1	COI	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes granulatus	59647	A0A3G2CKA6	Cytochrome c oxidase subunit 1	COI	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes granulatus	59647	A0A0U2D874	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes granulatus	59647	A0A3G2CK68	Cytochrome c oxidase subunit 1	COI	231	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes granulatus	59647	A0A2H4V5Y9	Cytochrome c oxidase subunit 1	COI	63	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes granulatus	59647	A0A0U2D863	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes granulatus	59647	A0A3G2CK99	Cytochrome c oxidase subunit 1	COI	227	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	B7XFT2	Ovatusin		74	Unreviewed	Secreted	defense response to bacterium		extracellular region	Antibiotic | Antimicrobial | Disulfide bond | Secreted | Signal		
Ixodes ovatus	59652	A0A0D4CET5	Cystatin 2a	cys2a	140	Unreviewed	Secreted		cysteine-type endopeptidase inhibitor activity	cytoplasm | extracellular space | vesicle	Protease inhibitor | Secreted | Signal | Thiol protease inhibitor		
Ixodes ovatus	59652	A0A7L8TBM8	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	Q64K80	Calreticulin		413	Unreviewed	Endoplasmic reticulum lumen	ERAD pathway | protein folding	calcium ion binding | carbohydrate binding | unfolded protein binding	endoplasmic reticulum lumen | endoplasmic reticulum membrane	Calcium | Chaperone | Disulfide bond | Endoplasmic reticulum | Lectin | Metal-binding | Repeat | Signal | Zinc		Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER
Ixodes ovatus	59652	Q0X074	Cytochrome c oxidase subunit 1	COI	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8TC98	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8TAN8	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8TBI4	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8TB85	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8TB19	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8TAM6	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8T9G0	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8T9X2	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8T9W8	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8T9W3	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8T9R5	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8T9P7	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8T9F5	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8T9E3	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8T9B1	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8T994	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8T901	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ovatus	59652	A0A7L8T9Z3	Cytochrome c oxidase subunit 1	COX1	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ricinus	34613	A0A131XQX7	Vacuolar protein sorting-associated protein 51 homolog		764	Unreviewed	Golgi apparatus, trans-Golgi network	endocytic recycling | Golgi organization | Golgi vesicle transport | lipid transport | lysosomal transport | protein transport | retrograde transport, endosome to Golgi		cytosol | EARP complex | GARP complex | membrane	Coiled coil | Golgi apparatus | Lipid transport | Protein transport | Transport		Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN)
Ixodes ricinus	34613	A0A131XQZ1	Protein phosphatase 1 regulatory subunit 12B		887	Unreviewed	Cytoplasm, cytoskeleton | Target cell membrane	exocytosis	enzyme inhibitor activity | phosphatase regulator activity | protein kinase binding	cytoplasm | cytoskeleton | host cell presynaptic membrane | other organism cell membrane	ANK repeat | Cytoplasm | Cytoskeleton | Developmental protein | Exocytosis | Membrane | Neurotoxin | Phosphoprotein | Presynaptic neurotoxin | Repeat | Target cell membrane | Target membrane | Toxin		Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus
Ixodes ricinus	34613	A0A131XRF7	Glycine--tRNA ligase		692	Unreviewed	Cell projection, axon | Cytoplasm | Mitochondrion	mitochondrial glycyl-tRNA aminoacylation	ATP binding | glycine-tRNA ligase activity | transferase activity	axon | mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Cell projection | Cytoplasm | Ligase | Mitochondrion | Nucleotide-binding | Protein biosynthesis | Transferase | Transit peptide		Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. Required for terminal arborization of both dendrites and axons during development
Ixodes ricinus	34613	A0A131XRG2	Polypeptide N-acetylgalactosaminyltransferase		591	Unreviewed	Golgi apparatus membrane	protein O-linked glycosylation	carbohydrate binding | metal ion binding | polypeptide N-acetylgalactosaminyltransferase activity	Golgi membrane	Disulfide bond | Glycoprotein | Glycosyltransferase | Golgi apparatus | Lectin | Manganese | Membrane | Metal-binding | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A131XRN4	RING-type E3 ubiquitin transferase		653	Unreviewed	Cytoplasm | Nucleus, PML body	interstrand cross-link repair | protein ubiquitination	ubiquitin protein ligase activity | zinc ion binding	cytoplasm | PML body	Coiled coil | Cytoplasm | DNA damage | DNA repair | Metal-binding | Nucleus | Repeat | Transferase | Ubl conjugation pathway | WD repeat | Zinc | Zinc-finger		
Ixodes ricinus	34613	A0A131XSI9	NAD(P) transhydrogenase, mitochondrial		1065	Unreviewed	Cell inner membrane | Mitochondrion inner membrane	NADPH regeneration	NADP binding | proton-translocating NAD(P)+ transhydrogenase activity	mitochondrial inner membrane | plasma membrane	Acetylation | Cell inner membrane | Cell membrane | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | NADP | Nucleotide-binding | Transit peptide | Translocase | Transmembrane | Transmembrane helix		The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland
Ixodes ricinus	34613	A0A131XSC9	Ubiquitin carboxyl-terminal hydrolase		383	Unreviewed		protein K48-linked deubiquitination | proteolysis	cysteine-type carboxypeptidase activity | cysteine-type deubiquitinase activity | histone deubiquitinase activity | K48-linked deubiquitinase activity | K48-linked polyubiquitin modification-dependent protein binding	cell periphery | cytosol	Hydrolase | Protease | Thiol protease | Ubl conjugation pathway		Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover
Ixodes ricinus	34613	A0A131XSD5	Phosphoinositide phospholipase C		1433	Unreviewed	Cytoplasm	gamma-aminobutyric acid signaling pathway | lipid catabolic process | phosphatidylinositol metabolic process | phosphatidylinositol-mediated signaling | regulation of synaptic transmission, GABAergic | release of sequestered calcium ion into cytosol	calcium ion binding | lyase activity | phosphatidylinositol-4,5-bisphosphate phospholipase C activity	cytoplasm	Cytoplasm | Disulfide bond | Hydrolase | Lipid degradation | Lipid metabolism | Lyase | Magnesium | Metal-binding | Transducer		
Ixodes ricinus	34613	A0A131XSE4	NADPH-dependent diflavin oxidoreductase 1		590	Unreviewed	Cytoplasm	iron-sulfur cluster assembly	flavin adenine dinucleotide binding | FMN binding | NADP binding | NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity | oxidoreductase activity, acting on NAD(P)H	cytosol | nucleus	Cytoplasm | FAD | Flavoprotein | FMN | NADP | Oxidoreductase		NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair. In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A
Ixodes ricinus	34613	A0A131XQH9	Protein wntless		561	Unreviewed	Endoplasmic reticulum membrane | Endosome membrane | Golgi apparatus membrane | Postsynaptic cell membrane | Presynaptic cell membrane	intracellular protein transport | Wnt protein secretion | Wnt signaling pathway	Wnt-protein binding	endoplasmic reticulum membrane | endosome membrane | Golgi membrane | postsynaptic membrane | presynaptic membrane	Cell projection | Developmental protein | Golgi apparatus | Membrane | Postsynaptic cell membrane | Synapse | Transmembrane | Transmembrane helix | Wnt signaling pathway		A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles. Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip
Ixodes ricinus	34613	A0A131XSJ0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		1251	Unreviewed		adult locomotory behavior | entrainment of circadian clock by photoperiod | G protein-coupled receptor signaling pathway | lipid catabolic process | phosphatidylinositol metabolic process | phosphatidylinositol-mediated signaling | release of sequestered calcium ion into cytosol	calcium ion binding | lyase activity | phosphatidylinositol-4,5-bisphosphate phospholipase C activity	cytoplasm	Calcium | Coiled coil | Disulfide bond | Hydrolase | Lipid degradation | Lipid metabolism | Lyase | Magnesium | Metal-binding | Phosphoprotein | Transducer		
Ixodes ricinus	34613	A0A131XRY3	E3 ubiquitin-protein ligase		1875	Unreviewed		proteasome-mediated ubiquitin-dependent protein catabolic process | protein K63-linked ubiquitination | regulation of signal transduction	metal ion binding | ubiquitin protein ligase activity	nuclear speck	Coiled coil | Transferase | Ubl conjugation pathway		E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates
Ixodes ricinus	34613	A0A131XQC3	E3 ubiquitin-protein ligase TRIM71		742	Unreviewed	Cytoplasm, P-body	negative regulation of translation | proteasome-mediated ubiquitin-dependent protein catabolic process | protein polyubiquitination | regulatory ncRNA-mediated gene silencing	miRNA binding | ubiquitin protein ligase activity | zinc ion binding	P-body	Coiled coil | Cytoplasm | Developmental protein | Metal-binding | Repeat | RNA-binding | RNA-mediated gene silencing | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		
Ixodes ricinus	34613	A0A131XNV2	Cytosol aminopeptidase		506	Unreviewed		proteolysis	manganese ion binding | metalloaminopeptidase activity	cytoplasm	Aminopeptidase | Hydrolase | Protease		Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status
Ixodes ricinus	34613	A0A131XPH2	Ecdysone receptor		436	Unreviewed	Nucleus	cell differentiation | ecdysone receptor signaling pathway | negative regulation of transcription by RNA polymerase II | positive regulation of transcription by RNA polymerase II	ecdysone binding | nuclear receptor activity | RNA polymerase II cis-regulatory region sequence-specific DNA binding | zinc ion binding	RNA polymerase II transcription regulator complex	DNA-binding | Metal-binding | Nucleus | Receptor | Transcription | Transcription regulation | Zinc | Zinc-finger		
Ixodes ricinus	34613	A0A131XPD2	Dolichol-phosphate mannosyltransferase subunit 1		239	Unreviewed	Endoplasmic reticulum	dolichol-linked oligosaccharide biosynthetic process | GPI anchor biosynthetic process | protein O-linked glycosylation via mannose	dolichyl-phosphate beta-D-mannosyltransferase activity | metal ion binding	endoplasmic reticulum membrane	Endoplasmic reticulum | Glycosyltransferase | Magnesium | Manganese | Metal-binding | Transferase		Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins
Ixodes ricinus	34613	A0A131XP82	Formimidoyltransferase-cyclodeaminase		541	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole | Golgi apparatus	L-histidine catabolic process to glutamate and formamide | L-histidine catabolic process to glutamate and formate	folic acid binding | formimidoyltetrahydrofolate cyclodeaminase activity | glutamate formimidoyltransferase activity	centriole | Golgi apparatus	Cytoplasm | Cytoskeleton | Folate-binding | Golgi apparatus | Histidine metabolism | Lyase | Multifunctional enzyme | Transferase		Binds and promotes bundling of vimentin filaments originating from the Golgi
Ixodes ricinus	34613	A0A131XNX7	Histone-lysine N-methyltransferase, H3 lysine-79 specific		1500	Unreviewed	Nucleus	DNA damage checkpoint signaling | DNA repair | methylation	histone H3K79 trimethyltransferase activity	histone methyltransferase complex	Chromatin regulator | Coiled coil | Methyltransferase | Nucleus | S-adenosyl-L-methionine | Transferase		Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone
Ixodes ricinus	34613	A0A131XSK2	Sodium/potassium-transporting ATPase subunit alpha		1033	Unreviewed	Cell membrane	intracellular potassium ion homeostasis | intracellular sodium ion homeostasis | potassium ion import across plasma membrane | proton transmembrane transport | sodium ion export across plasma membrane	ATP binding | ATP hydrolysis activity | metal ion binding | P-type sodium:potassium-exchanging transporter activity	cation-transporting ATPase complex | plasma membrane protein complex	ATP-binding | Cell membrane | Ion transport | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Potassium | Potassium transport | Sodium | Sodium transport | Sodium/potassium transport | Translocase | Transmembrane | Transmembrane helix | Transport		This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients
Ixodes ricinus	34613	A0A131XNF7	Vesicle transport through interaction with t-SNAREs homolog 1A		217	Unreviewed	Endomembrane system | Golgi apparatus membrane	Golgi to vacuole transport | intra-Golgi vesicle-mediated transport | intracellular protein transport | macroautophagy | retrograde transport, endosome to Golgi | vesicle fusion with Golgi apparatus	SNAP receptor activity | SNARE binding	cytosol | endoplasmic reticulum membrane | ER to Golgi transport vesicle membrane | Golgi membrane | late endosome membrane | SNARE complex	Coiled coil | Golgi apparatus | Membrane | Protein transport | Transmembrane | Transmembrane helix | Transport		
Ixodes ricinus	34613	A0A0K8RS62	ADP/ATP translocase		250	Unreviewed	Membrane | Mitochondrion inner membrane	mitochondrial ADP transmembrane transport | mitochondrial ATP transmembrane transport | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ATP:ADP antiporter activity	mitochondrial inner membrane	Antiport | Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane
Ixodes ricinus	34613	A0A0K8RRY2	Ragulator complex protein LAMTOR1		217	Unreviewed	Late endosome membrane | Lysosome membrane	cellular response to amino acid stimulus | cholesterol homeostasis | endosomal transport | lysosome organization | positive regulation of MAPK cascade | positive regulation of TOR signaling | regulation of receptor recycling	guanyl-nucleotide exchange factor activity | molecular adaptor activity	late endosome membrane | lysosomal membrane | membrane raft | Ragulator complex	Endosome | Lipoprotein | Lysosome | Membrane | Myristate | Palmitate		
Ixodes ricinus	34613	A0A0K8RRK2	Putative secreted protein		210	Unreviewed	Endomembrane system			endomembrane system | membrane	Membrane | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A0K8RQX3	Adenosine kinase		325	Unreviewed	Nucleus	AMP salvage | purine nucleobase metabolic process | purine ribonucleoside salvage	adenosine kinase activity | ATP binding	cytosol | nucleus	ATP-binding | Kinase | Magnesium | Nucleotide-binding | Nucleus | Purine salvage | Transferase		ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives
Ixodes ricinus	34613	A0A0K8RQT7	adenosylmethionine decarboxylase		371	Unreviewed		spermidine biosynthetic process | spermine biosynthetic process	adenosylmethionine decarboxylase activity	cytosol	Autocatalytic cleavage | Decarboxylase | Lyase | Polyamine biosynthesis | Pyruvate | S-adenosyl-L-methionine | Schiff base | Spermidine biosynthesis | Zymogen		
Ixodes ricinus	34613	A0A0K8RQR9	Integrin beta		495	Unreviewed	Cell membrane | Cell projection, lamellipodium membrane | Postsynaptic cell membrane	cell adhesion mediated by integrin | cell migration | cell-matrix adhesion | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | integrin-mediated signaling pathway | positive regulation of cell migration | positive regulation of cell population proliferation	integrin binding | metal ion binding	cell surface | focal adhesion | integrin complex | lamellipodium membrane | postsynaptic membrane	Calcium | Cell adhesion | Cell membrane | Disulfide bond | EGF-like domain | Glycoprotein | Integrin | Magnesium | Membrane | Metal-binding | Postsynaptic cell membrane | Repeat | Signal | Synapse | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A0K8RQB6	Succinate-CoA ligase subunit beta		474	Unreviewed		succinyl-CoA metabolic process | tricarboxylic acid cycle	ATP binding | metal ion binding | succinate-CoA ligase (ADP-forming) activity | succinate-CoA ligase (GDP-forming) activity	mitochondrion | succinate-CoA ligase complex	ATP-binding | Ligase | Magnesium | Metal-binding | Mitochondrion | Nucleotide-binding | Transit peptide | Tricarboxylic acid cycle		GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
Ixodes ricinus	34613	A0A131XPS0	Probable ATP-dependent RNA helicase DDX23		789	Unreviewed	Nucleus	mRNA splicing, via spliceosome	ATP binding | hydrolase activity | nucleic acid binding | RNA helicase activity	nucleus	ATP-binding | Helicase | Hydrolase | mRNA processing | mRNA splicing | Nucleotide-binding | Nucleus		Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA
Ixodes ricinus	34613	A0A131XSP1	non-specific serine/threonine protein kinase		228	Unreviewed	Nucleus	tRNA processing | tRNA threonylcarbamoyladenosine metabolic process	ATP binding | hydrolase activity | protein serine/threonine kinase activity	cytosol | EKC/KEOPS complex | nucleus	ATP-binding | Hydrolase | Kinase | Nucleotide-binding | Nucleus | Phosphoprotein | Serine/threonine-protein kinase | Transferase | tRNA processing		Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation
Ixodes ricinus	34613	A0A131XSY8	General transcription and DNA repair factor IIH helicase subunit XPD		764	Unreviewed	Nucleus	hair cell differentiation | nucleotide-excision repair | positive regulation of mitotic recombination | transcription by RNA polymerase II	4 iron, 4 sulfur cluster binding | 5'-3' DNA helicase activity | ATP binding | damaged DNA binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | metal ion binding	nucleus	4Fe-4S | ATP-binding | Coiled coil | DNA damage | DNA repair | DNA-binding | Helicase | Hydrolase | Iron | Iron-sulfur | Isomerase | Metal-binding | Nucleotide-binding | Nucleus | Transcription | Transcription regulation		
Ixodes ricinus	34613	A0A131XSR3	HECT-type E3 ubiquitin transferase		793	Unreviewed	Cytoplasm	negative regulation of smoothened signaling pathway | positive regulation of receptor-mediated endocytosis | protein ubiquitination | regulation of dendrite morphogenesis | ubiquitin-dependent protein catabolic process	sodium channel inhibitor activity | ubiquitin protein ligase activity	cytoplasm	Cytoplasm | Phosphoprotein | Repeat | Transferase | Ubl conjugation | Ubl conjugation pathway		
Ixodes ricinus	34613	A0A131XUY0	E3 ubiquitin-protein ligase E3D		386	Unreviewed		proteasome-mediated ubiquitin-dependent protein catabolic process | protein autoubiquitination | protein monoubiquitination | protein polyubiquitination	cyclin binding | ubiquitin conjugating enzyme binding | ubiquitin protein ligase activity	cytosol | nucleus | ubiquitin ligase complex			E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site
Ixodes ricinus	34613	A0A131XUW1	non-specific serine/threonine protein kinase		1517	Unreviewed	Cytoplasm, myofibril, sarcomere, A band | Cytoplasm, myofibril, sarcomere, I band | Nucleus	anatomical structure morphogenesis | cell differentiation | positive regulation of locomotion | positive regulation of sarcomere organization | positive regulation of striated muscle contraction	actin binding | calmodulin binding | metal ion binding | protein serine/threonine kinase activity	A band | I band | nucleus	Calcium | Calmodulin-binding | Coiled coil | Cytoplasm | Disulfide bond | Immunoglobulin domain | Kinase | Magnesium | Metal-binding | Nucleus | Repeat | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A131XUS7	DNA-directed primase/polymerase protein		436	Unreviewed		error-prone translesion synthesis | mitochondrial DNA replication | replication fork processing | response to UV	chromatin binding | DNA-directed DNA polymerase activity	mitochondrial matrix | nucleus	DNA-directed DNA polymerase | Nucleotidyltransferase | Transferase		
Ixodes ricinus	34613	A0A131XUS1	CCR4-NOT transcription complex subunit 4		541	Unreviewed	Cytoplasm | Nucleus	protein ubiquitination	RNA binding | ubiquitin protein ligase activity | zinc ion binding	CCR4-NOT complex | cytosol | nucleus	Coiled coil | Cytoplasm | Metal-binding | Methylation | Nucleus | Phosphoprotein | RNA-binding | Transferase | Ubl conjugation | Ubl conjugation pathway | Zinc | Zinc-finger		Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy
Ixodes ricinus	34613	A0A131XUQ7	SNF-related serine/threonine-protein kinase		734	Unreviewed	Nucleus	intracellular signal transduction	ATP binding | metal ion binding | protein serine/threonine kinase activity	cytoplasm | nucleus	ATP-binding | Kinase | Magnesium | Metal-binding | Methylation | Nucleotide-binding | Nucleus | Phosphoprotein | Serine/threonine-protein kinase | Transferase		May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis
Ixodes ricinus	34613	A0A131XUN2	alpha-1,2-Mannosidase		551	Unreviewed	Endoplasmic reticulum membrane	carbohydrate metabolic process | proteasomal protein catabolic process | response to endoplasmic reticulum stress	calcium ion binding | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum membrane	Calcium | Disulfide bond | Endoplasmic reticulum | Glycosidase | Hydrolase | Membrane | Metal-binding | Signal-anchor | Transmembrane | Transmembrane helix		Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2)
Ixodes ricinus	34613	A0A131XUJ7	Mitogen-activated protein kinase		372	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Cytoplasm, cytoskeleton, spindle	apoptotic process	ATP binding | MAP kinase activity | protein serine kinase activity	centrosome | spindle	Apoptosis | ATP-binding | Cell cycle | Cytoplasm | Cytoskeleton | Kinase | Magnesium | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A131XUJ5	Lon protease homolog		1021	Unreviewed	Mitochondrion matrix	chaperone-mediated protein complex assembly | mitochondrion organization | protein quality control for misfolded or incompletely synthesized proteins	ATP binding | ATP hydrolysis activity | ATP-dependent peptidase activity | serine-type endopeptidase activity | single-stranded DNA binding	mitochondrial matrix	ATP-binding | DNA-binding | Hydrolase | Mitochondrion | Nucleotide-binding | Protease | Serine protease | Transit peptide		
Ixodes ricinus	34613	A0A131XUJ2	Eukaryotic translation initiation factor 3 subunit B		725	Unreviewed	Cytoplasm	formation of cytoplasmic translation initiation complex	RNA binding | translation initiation factor activity | translation initiation factor binding	eukaryotic 43S preinitiation complex | eukaryotic 48S preinitiation complex | eukaryotic translation initiation factor 3 complex	Coiled coil | Cytoplasm | Initiation factor | Protein biosynthesis | Repeat | RNA-binding | WD repeat		Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome
Ixodes ricinus	34613	A0A131XUB8	CAAX prenyl protease		487	Unreviewed	Endoplasmic reticulum membrane	CAAX-box protein processing	metal ion binding | metalloendopeptidase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | Hydrolase | Membrane | Metal-binding | Metalloprotease | Protease | Transmembrane | Transmembrane helix | Zinc		Proteolytically removes the C-terminal three residues of farnesylated proteins
Ixodes ricinus	34613	A0A131XU97	Autophagy protein 5		270	Unreviewed	Cytoplasm | Preautophagosomal structure membrane	apoptotic process | autophagosome assembly | autophagy of mitochondrion | cellular response to nitrogen starvation | immune system process | negative regulation of programmed cell death | piecemeal microautophagy of the nucleus	Atg8-family ligase activity	Atg12-Atg5-Atg16 complex | autophagosome | mitochondria-associated endoplasmic reticulum membrane contact site | phagophore | phagophore assembly site membrane	Acetylation | Apoptosis | Autophagy | Cytoplasm | Immunity | Isopeptide bond | Membrane | Ubl conjugation		Involved in autophagic vesicle formation
Ixodes ricinus	34613	A0A131XU96	Ras-related protein Rab-14		215	Unreviewed	Cytoplasmic vesicle | Early endosome membrane | Golgi apparatus, trans-Golgi network membrane | Recycling endosome	defense response to bacterium | endocytic recycling | Golgi to endosome transport | phagosome maturation | protein transport	G protein activity | GTP binding	cytosol | early endosome membrane | phagocytic vesicle | recycling endosome | trans-Golgi network	Acetylation | Cytoplasmic vesicle | Endosome | Golgi apparatus | GTP-binding | Hydrolase | Lipoprotein | Membrane | Methylation | Nucleotide-binding | Prenylation | Protein transport | Transport		
Ixodes ricinus	34613	A0A131XU82	Serine/threonine-protein kinase ULK3		467	Unreviewed	Cytoplasm	autophagosome assembly | autophagy of mitochondrion | piecemeal microautophagy of the nucleus | regulation of autophagy | response to starvation | reticulophagy	ATP binding | protein serine/threonine kinase activity	autophagosome | cytosol | phagophore assembly site membrane	ATP-binding | Autophagy | Cytoplasm | Kinase | Nucleotide-binding | Repeat | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A131XU58	ATPase ASNA1 homolog		335	Unreviewed	Cytoplasm | Endoplasmic reticulum	tail-anchored membrane protein insertion into ER membrane	ATP binding | ATP hydrolysis activity | metal ion binding	GET complex	ATP-binding | Cytoplasm | Endoplasmic reticulum | Hydrolase | Metal-binding | Nucleotide-binding | Transport | Zinc		ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting
Ixodes ricinus	34613	A0A131XTR5	Translation factor GUF1 homolog, mitochondrial		661	Unreviewed	Mitochondrion inner membrane	positive regulation of translation | translation	GTP binding | GTPase activity | mitochondrial ribosome binding	mitochondrial inner membrane | mitochondrial matrix	GTP-binding | Hydrolase | Membrane | Mitochondrion | Mitochondrion inner membrane | Nucleotide-binding | Protein biosynthesis		Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner
Ixodes ricinus	34613	A0A131XTR3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		1102	Unreviewed		adult locomotory behavior | entrainment of circadian clock by photoperiod | lipid catabolic process | phosphatidylinositol metabolic process | phosphatidylinositol-mediated signaling | release of sequestered calcium ion into cytosol	calcium ion binding | lyase activity | phosphatidylinositol-4,5-bisphosphate phospholipase C activity		Calcium | Coiled coil | Disulfide bond | Hydrolase | Lipid degradation | Lipid metabolism | Lyase | Magnesium | Metal-binding | Transducer		The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes
Ixodes ricinus	34613	A0A131XTI9	histone acetyltransferase		2329	Unreviewed	Cytoplasm | Nucleus	positive regulation of transcription by RNA polymerase II | rhythmic process	chromatin DNA binding | DNA-binding transcription factor binding | histone acetyltransferase activity | transcription coactivator activity | zinc ion binding	cytoplasm | histone acetyltransferase complex | nuclear lumen | transcription regulator complex	Acetylation | Activator | Acyltransferase | Biological rhythms | Bromodomain | Chromatin regulator | Cytoplasm | Isopeptide bond | Metal-binding | Methylation | Nucleus | Phosphoprotein | Repeat | Transcription | Transcription regulation | Transferase | Ubl conjugation | Zinc | Zinc-finger		
Ixodes ricinus	34613	A0A131XTE8	protein kinase C		849	Unreviewed	Cytoplasm | Membrane	intracellular signal transduction | phospholipase C-activating G protein-coupled receptor signaling pathway	ATP binding | diacylglycerol-dependent serine/threonine kinase activity | zinc ion binding	cytosol | membrane	ATP-binding | Cytoplasm | Kinase | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Repeat | Serine/threonine-protein kinase | Transferase | Zinc | Zinc-finger		
Ixodes ricinus	34613	A0A131XTB3	(3R)-3-hydroxyacyl-CoA dehydrogenase		295	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	A0A131XTA1	Crossover junction endonuclease MUS81		374	Unreviewed	Nucleus	DNA catabolic process | double-strand break repair via break-induced replication | mitotic intra-S DNA damage checkpoint signaling | resolution of meiotic recombination intermediates	3'-flap endonuclease activity | crossover junction DNA endonuclease activity | DNA binding | metal ion binding	Holliday junction resolvase complex | nucleus	DNA damage | DNA recombination | DNA repair | Endonuclease | Hydrolase | Magnesium | Meiosis | Metal-binding | Nuclease | Nucleus		Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI)
Ixodes ricinus	34613	A0A131XT91	E3 ubiquitin-protein ligase		873	Unreviewed	Cell membrane	cell differentiation | ectoderm development | negative regulation of BMP signaling pathway | proteasome-mediated ubiquitin-dependent protein catabolic process | protein ubiquitination	ubiquitin protein ligase activity	cytoplasm | plasma membrane	Cell membrane | Differentiation | Membrane | Repeat | Transferase | Ubl conjugation pathway		
Ixodes ricinus	34613	A0A131XT46	Heat shock protein 75 kDa, mitochondrial		658	Unreviewed	Mitochondrion inner membrane | Mitochondrion matrix		ATP binding | ATP hydrolysis activity | ATP-dependent protein folding chaperone | protein kinase binding | unfolded protein binding	mitochondrial inner membrane | mitochondrial matrix	Acetylation | ATP-binding | Chaperone | Membrane | Mitochondrion | Mitochondrion inner membrane | Nucleotide-binding | Phosphoprotein | Stress response | Transit peptide		Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA
Ixodes ricinus	34613	A0A131XT24	E3 ubiquitin-protein ligase listerin		1754	Unreviewed	Cytoplasm, cytosol	protein ubiquitination | rescue of stalled ribosome | ribosome-associated ubiquitin-dependent protein catabolic process	ribosomal large subunit binding | ubiquitin protein ligase activity | zinc ion binding	cytosol | RQC complex	Cytoplasm | Metal-binding | Repeat | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation
Ixodes ricinus	34613	A0A131XSZ1	alpha-1,2-Mannosidase		1033	Unreviewed	Endoplasmic reticulum	carbohydrate metabolic process | endoplasmic reticulum mannose trimming | positive regulation of retrograde protein transport, ER to cytosol	calcium ion binding | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum quality control compartment | membrane	Calcium | Endoplasmic reticulum | Glycoprotein | Glycosidase | Hydrolase | Metal-binding | Signal		Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins
Ixodes ricinus	34613	A0A0K8RQ68	Mitochondrial 2-oxodicarboxylate carrier		152	Unreviewed	Mitochondrion inner membrane			mitochondrial inner membrane	Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle
Ixodes ricinus	34613	A0A131XSW8	Dual serine/threonine and tyrosine protein kinase		1004	Unreviewed	Cytoplasm	cellular response to fibroblast growth factor stimulus | negative regulation of apoptotic process | positive regulation of ERK1 and ERK2 cascade | positive regulation of fibroblast growth factor receptor signaling pathway	ATP binding | protein serine/threonine kinase activity | protein serine/threonine/tyrosine kinase activity | protein tyrosine kinase activity	cytoplasm	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase | Tyrosine-protein kinase		
Ixodes ricinus	34613	A0A131XST7	furin		705	Unreviewed	Membrane	neuron differentiation | peptide hormone processing	serine-type endopeptidase activity	Golgi membrane | trans-Golgi network	Cleavage on pair of basic residues | Glycoprotein | Hydrolase | Membrane | Protease | Serine protease | Signal | Zymogen		Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif
Ixodes ricinus	34613	A0A131XSP8	Lysine-specific histone demethylase		773	Unreviewed	Chromosome | Nucleus	methylation | positive regulation of cell population proliferation | regulation of DNA-templated transcription	chromatin binding | FAD-dependent H3K4me/H3K4me3 demethylase activity | flavin adenine dinucleotide binding | methyltransferase activity | RNA binding	chromosome | nucleus	Chromatin regulator | Chromosome | Coiled coil | FAD | Flavoprotein | Methyltransferase | Nucleus | Oxidoreductase | Phosphoprotein | Repressor | Transcription | Transcription regulation | Transferase		Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3
Ixodes ricinus	34613	A0A0K8RQ37	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha		327	Unreviewed			CAAX-protein geranylgeranyltransferase activity | protein farnesyltransferase activity	CAAX-protein geranylgeranyltransferase complex | protein farnesyltransferase complex	Acetylation | Magnesium | Prenyltransferase | Repeat | Transferase		Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation
Ixodes ricinus	34613	A0A0K8RPM0	(3R)-3-hydroxyacyl-CoA dehydrogenase		335	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	A0A0K8RPV2	Casein kinase II subunit alpha		402	Unreviewed		regulation of cell cycle	ATP binding | protein serine/threonine kinase activity	cytosol | nucleus | protein kinase CK2 complex	ATP-binding | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase		Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling
Ixodes ricinus	34613	A0A0K8RI22	Tyrosine-protein kinase		808	Unreviewed	Endomembrane system	cell development | morphogenesis of an epithelium | neuron differentiation | positive regulation of cellular component organization | regulation of developmental process	ATP binding | non-membrane spanning protein tyrosine kinase activity | transmembrane receptor protein tyrosine kinase activity	endomembrane system	ATP-binding | Coiled coil | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | SH2 domain | Transferase | Tyrosine-protein kinase		
Ixodes ricinus	34613	A0A0K8RHX7	SUMO-activating enzyme subunit		610	Unreviewed	Nucleus	protein sumoylation	ATP binding | metal ion binding | SUMO activating enzyme activity | transferase activity	cytoplasm | SUMO activating enzyme complex	ATP-binding | Metal-binding | Nucleotide-binding | Nucleus | Transferase | Ubl conjugation pathway | Zinc		
Ixodes ricinus	34613	A0A0K8RHW1	Phosphoacetylglucosamine mutase		547	Unreviewed		carbohydrate metabolic process | UDP-N-acetylglucosamine biosynthetic process	magnesium ion binding | phosphoacetylglucosamine mutase activity		Acetylation | Carbohydrate metabolism | Isomerase | Magnesium | Metal-binding | Phosphoprotein		Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation
Ixodes ricinus	34613	A0A0K8RHS5	Vesicle transport through interaction with t-SNAREs homolog 1A		217	Unreviewed	Endomembrane system | Golgi apparatus membrane	Golgi to vacuole transport | intra-Golgi vesicle-mediated transport | intracellular protein transport | macroautophagy | retrograde transport, endosome to Golgi | vesicle fusion with Golgi apparatus	SNAP receptor activity | SNARE binding	cytosol | endoplasmic reticulum membrane | ER to Golgi transport vesicle membrane | Golgi membrane | late endosome membrane | SNARE complex	Coiled coil | Golgi apparatus | Membrane | Protein transport | Transmembrane | Transmembrane helix | Transport		
Ixodes ricinus	34613	A0A0K8RHP9	N-alpha-acetyltransferase 20		173	Unreviewed	Cytoplasm | Nucleus		protein N-terminal-methionine acetyltransferase activity	NatB complex | nucleus	Acyltransferase | Cytoplasm | Nucleus | Transferase		Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration
Ixodes ricinus	34613	A0A0K8RHN3	2-hydroxyacyl-CoA lyase 1		575	Unreviewed	Peroxisome	fatty acid alpha-oxidation	2-hydroxyacyl-CoA lyase activity | magnesium ion binding | thiamine pyrophosphate binding	peroxisome	Fatty acid metabolism | Lipid metabolism | Lyase | Magnesium | Metal-binding | Peroxisome | Phosphoprotein | Thiamine pyrophosphate		
Ixodes ricinus	34613	A0A0K8RGZ1	Molybdopterin synthase catalytic subunit		179	Unreviewed	Cytoplasm	Mo-molybdopterin cofactor biosynthetic process	molybdopterin synthase activity	molybdopterin synthase complex	Cytoplasm | Membrane | Molybdenum cofactor biosynthesis | Transferase | Transmembrane | Transmembrane helix		Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group
Ixodes ricinus	34613	A0A0K8RGN5	Eukaryotic translation initiation factor 3 subunit B		725	Unreviewed	Cytoplasm	formation of cytoplasmic translation initiation complex	RNA binding | translation initiation factor activity | translation initiation factor binding	eukaryotic 43S preinitiation complex | eukaryotic 48S preinitiation complex | eukaryotic translation initiation factor 3 complex	Coiled coil | Cytoplasm | Initiation factor | Protein biosynthesis | Repeat | RNA-binding | WD repeat		Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome
Ixodes ricinus	34613	A0A0K8RGN0	Aminopeptidase		865	Unreviewed	Cell membrane | Cytoplasm	peptide catabolic process | proteolysis	alanyl aminopeptidase activity | metalloaminopeptidase activity | peptide binding | zinc ion binding	cytoplasm | extracellular space | plasma membrane	Aminopeptidase | Cytoplasm | Hydrolase | Metal-binding | Metalloprotease | Protease | Zinc		
Ixodes ricinus	34613	A0A0K8RGK7	Mitochondrial 2-oxodicarboxylate carrier		305	Unreviewed	Mitochondrion inner membrane			mitochondrial inner membrane	Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle
Ixodes ricinus	34613	A0A0K8RGH0	Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1		195	Unreviewed	Membrane	phospholipid biosynthetic process	phosphatidylglycerophosphatase activity | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | phosphoprotein phosphatase activity	cytoplasm | membrane	Hydrolase | Lipid biosynthesis | Lipid metabolism | Membrane | Phospholipid biosynthesis | Phospholipid metabolism | Protein phosphatase		
Ixodes ricinus	34613	A0A0K8RGA6	Alanine--tRNA ligase		968	Unreviewed		alanyl-tRNA aminoacylation	alanine-tRNA ligase activity | aminoacyl-tRNA deacylase activity | ATP binding | tRNA binding | zinc ion binding	mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Coiled coil | Cytoplasm | Ligase | Metal-binding | Nucleotide-binding | Protein biosynthesis | RNA-binding | tRNA-binding | Zinc		Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain
Ixodes ricinus	34613	A0A0K8RG01	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	334	Unreviewed		glucose metabolic process | glyceraldehyde-3-phosphate metabolic process | glycolytic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | NAD binding | NADP binding	cytosol	Glycolysis | NAD | Nucleotide-binding | Oxidoreductase		
Ixodes ricinus	34613	A0A0K8RIF9	Long-chain-fatty-acid--CoA ligase		718	Unreviewed			arachidonate-CoA ligase activity | ATP binding	endoplasmic reticulum | membrane	ATP-binding | Fatty acid metabolism | Ligase | Lipid metabolism | Membrane | Nucleotide-binding | Transmembrane | Transmembrane helix		Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation
Ixodes ricinus	34613	A0A0K8RFU4	Glucosamine-6-phosphate isomerase		282	Unreviewed	Cytoplasm	carbohydrate metabolic process | glucosamine catabolic process | N-acetylglucosamine catabolic process | N-acetylneuraminate catabolic process	glucosamine-6-phosphate deaminase activity | identical protein binding | isomerase activity	cytoplasm	Carbohydrate metabolism | Cytoplasm | Hydrolase | Isomerase		Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway
Ixodes ricinus	34613	A0A0K8RFL9	NAD-dependent protein deacylase		296	Unreviewed	Mitochondrion		histone deacetylase activity, NAD-dependent | NAD+ binding | protein-glutaryllysine deglutarylase activity | protein-malonyllysine demalonylase activity | protein-succinyllysine desuccinylase activity | zinc ion binding	mitochondrion | nucleus	Metal-binding | Mitochondrion | NAD | Transferase | Zinc		NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo
Ixodes ricinus	34613	A0A0K8RFD7	Cytochrome c1, heme protein, mitochondrial		310	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	electron transfer activity | heme binding | metal ion binding	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
Ixodes ricinus	34613	A0A0K8REQ2	Mitochondrial 2-oxodicarboxylate carrier		306	Unreviewed	Mitochondrion inner membrane	transmembrane transport		mitochondrial inner membrane	Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle
Ixodes ricinus	34613	A0A0K8REP0	Pyridoxal kinase		302	Unreviewed		pyridoxal 5'-phosphate salvage	ATP binding | pyridoxal kinase activity	cytosol	ATP-binding | Kinase | Nucleotide-binding | Transferase		
Ixodes ricinus	34613	A0A0K8RE77	4-hydroxybenzoate polyprenyltransferase, mitochondrial		382	Unreviewed	Membrane | Mitochondrion inner membrane	isoprenoid biosynthetic process | ubiquinone biosynthetic process	4-hydroxybenzoate polyprenyltransferase activity	mitochondrial inner membrane	Isoprene biosynthesis | Membrane | Mitochondrion | Mitochondrion inner membrane | Transferase | Transmembrane | Transmembrane helix | Ubiquinone biosynthesis		Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate
Ixodes ricinus	34613	A0A0K8RDN8	Ribonuclease		357	Unreviewed		DNA replication, removal of RNA primer | mismatch repair	metal ion binding | RNA binding | RNA-DNA hybrid ribonuclease activity	ribonuclease H2 complex	Endonuclease | Hydrolase | Metal-binding | Nuclease		Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes
Ixodes ricinus	34613	A0A0K8RDJ5	4-hydroxyphenylpyruvate dioxygenase		381	Unreviewed	Cytoplasm | Endoplasmic reticulum membrane | Golgi apparatus membrane	L-phenylalanine catabolic process | L-tyrosine catabolic process	4-hydroxyphenylpyruvate dioxygenase activity | metal ion binding | protein homodimerization activity	endoplasmic reticulum membrane | Golgi membrane	Cytoplasm | Dioxygenase | Endoplasmic reticulum | Golgi apparatus | Iron | Membrane | Metal-binding | Oxidoreductase | Phenylalanine catabolism | Pyruvate | Repeat | Tyrosine catabolism		Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism
Ixodes ricinus	34613	A0A0K8RD96	Phosphotransferase		475	Unreviewed		glucose metabolic process | glycolytic process | intracellular glucose homeostasis	ATP binding | D-glucose binding | fructokinase activity | glucokinase activity | mannokinase activity	cytosol | mitochondrion	ATP-binding | Glycolysis | Kinase | Nucleotide-binding | Transferase		Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate
Ixodes ricinus	34613	A0A0K8RD90	Methionine aminopeptidase		380	Unreviewed	Cytoplasm	proteolysis	initiator methionyl aminopeptidase activity | metalloaminopeptidase activity | zinc ion binding	cytosol	Aminopeptidase | Cytoplasm | Hydrolase | Metal-binding | Protease | Zinc | Zinc-finger		Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)
Ixodes ricinus	34613	A0A0K8RD89	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial		422	Unreviewed	Mitochondrion	succinyl-CoA metabolic process | tricarboxylic acid cycle	ATP binding | GTP binding | magnesium ion binding | succinate-CoA ligase (ADP-forming) activity | succinate-CoA ligase (GDP-forming) activity	mitochondrion | succinate-CoA ligase complex	GTP-binding | Ligase | Magnesium | Metal-binding | Mitochondrion | Nucleotide-binding | Tricarboxylic acid cycle		GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
Ixodes ricinus	34613	A0A0K8RCW3	glycine hydroxymethyltransferase		496	Unreviewed		glycine biosynthetic process from serine | methylation | tetrahydrofolate interconversion	glycine hydroxymethyltransferase activity | methyltransferase activity | pyridoxal phosphate binding	mitochondrion	Methyltransferase | One-carbon metabolism | Pyridoxal phosphate | Transferase		Interconversion of serine and glycine
Ixodes ricinus	34613	A0A0K8RCL0	Phosphoglycerate kinase		453	Unreviewed		gluconeogenesis | glycolytic process	ADP binding | ATP binding | metal ion binding | phosphoglycerate kinase activity	cytosol	ATP-binding | Glycolysis | Kinase | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Transferase | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A0K8RCB8	Serine protease HTRA2, mitochondrial		429	Unreviewed	Mitochondrion intermembrane space | Mitochondrion membrane	apoptotic process | mitochondrion organization | positive regulation of apoptotic process | proteolysis	serine-type endopeptidase activity	mitochondrial intermembrane space | mitochondrial membrane	Apoptosis | Hydrolase | Membrane | Mitochondrion | Protease | Serine protease | Transit peptide | Transmembrane | Transmembrane helix | Zymogen		Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th/Diap1 by directly inducing the degradation of th/Diap1
Ixodes ricinus	34613	A0A0K8RFS0	Putative secreted protein		232	Unreviewed	Endomembrane system			endomembrane system | membrane	Membrane | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A0K8RPW1	(3R)-3-hydroxyacyl-CoA dehydrogenase		300	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	A0A0K8RII9	RuvB-like helicase		458	Unreviewed	Nucleus	chromatin organization | DNA recombination | DNA repair | positive regulation of gene expression | regulation of canonical Wnt signaling pathway | regulation of cell population proliferation	ATP binding | ATP hydrolysis activity | DNA helicase activity | transcription coregulator activity	histone acetyltransferase complex | nucleus	ATP-binding | Chromatin regulator | DNA damage | DNA recombination | DNA repair | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Transcription | Transcription regulation		Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair
Ixodes ricinus	34613	A0A0K8RIU3	Endoplasmic reticulum chaperone BIP		658	Unreviewed	Endoplasmic reticulum lumen	endoplasmic reticulum unfolded protein response	ATP binding | ATP-dependent protein folding chaperone | hydrolase activity	endoplasmic reticulum lumen	ATP-binding | Chaperone | Coiled coil | Endoplasmic reticulum | Hydrolase | Nucleotide-binding | Signal | Stress response		
Ixodes ricinus	34613	A0A0K8RPT0	Bifunctional lysine-specific demethylase and histidyl-hydroxylase		439	Unreviewed	Nucleus, nucleolus	ribosome biogenesis	histone H3K36me/H3K36me2 demethylase activity | histone H3K4 demethylase activity | iron ion binding | peptidyl-histidine dioxygenase activity	nucleolus	Dioxygenase | Iron | Metal-binding | Nucleus | Oxidoreductase | Ribosome biogenesis | Transcription | Transcription regulation		Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles
Ixodes ricinus	34613	A0A0K8RPN1	(3R)-3-hydroxyacyl-CoA dehydrogenase		323	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	A0A131XV22	MAP/microtubule affinity-regulating kinase 3		803	Unreviewed	Cell membrane | Cell projection | Cytoplasm, cell cortex	intracellular signal transduction | microtubule cytoskeleton organization	ATP binding | protein serine kinase activity | tau-protein kinase activity	cell cortex | cell projection | plasma membrane	ATP-binding | Cell membrane | Cell projection | Cytoplasm | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Transferase		Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1
Ixodes ricinus	34613	A0A0K8RPJ5	Lysine--tRNA ligase		561	Unreviewed	Cell membrane | Cytoplasm, cytosol | Nucleus | Secreted	lysyl-tRNA aminoacylation	ATP binding | lysine-tRNA ligase activity | transferase activity | tRNA binding	aminoacyl-tRNA synthetase multienzyme complex | cytosol | extracellular region | mitochondrion | nucleus | plasma membrane	Acetylation | Aminoacyl-tRNA synthetase | ATP-binding | Cell membrane | Cytoplasm | Ligase | Membrane | Nucleotide-binding | Nucleus | Phosphoprotein | Protein biosynthesis | Secreted | Transferase		Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity
Ixodes ricinus	34613	A0A0K8RPI8	Geranylgeranyl transferase type-2 subunit alpha		593	Unreviewed			CAAX-protein geranylgeranyltransferase activity | protein farnesyltransferase activity | Rab geranylgeranyltransferase activity	CAAX-protein geranylgeranyltransferase complex | protein farnesyltransferase complex	Leucine-rich repeat | Magnesium | Prenyltransferase | Repeat | Transferase		
Ixodes ricinus	34613	A0A0K8RPB1	isocitrate dehydrogenase (NADP(+))		438	Unreviewed		glyoxylate cycle | isocitrate metabolic process | NADP+ metabolic process | tricarboxylic acid cycle	isocitrate dehydrogenase (NADP+) activity | magnesium ion binding | NAD binding	mitochondrion	Glyoxylate bypass | Magnesium | Manganese | Metal-binding | NADP | Oxidoreductase | Tricarboxylic acid cycle		
Ixodes ricinus	34613	A0A0K8RNP1	(3R)-3-hydroxyacyl-CoA dehydrogenase		250	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	A0A0K8RNI9	3'(2'),5'-bisphosphate nucleotidase 1		319	Unreviewed		phosphatidylinositol phosphate biosynthetic process	3'(2'),5'-bisphosphate nucleotidase activity | inositol-1,4-bisphosphate 1-phosphatase activity | metal ion binding		Hydrolase | Lithium | Magnesium | Metal-binding		
Ixodes ricinus	34613	A0A0K8RN83	Calreticulin		413	Unreviewed	Endoplasmic reticulum lumen	ERAD pathway | protein folding	calcium ion binding | carbohydrate binding | unfolded protein binding	endoplasmic reticulum lumen | endoplasmic reticulum membrane	Calcium | Chaperone | Disulfide bond | Endoplasmic reticulum | Lectin | Metal-binding | Repeat | Signal | Zinc		Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER
Ixodes ricinus	34613	A0A0K8RN58	Glutathione S-transferase 3, mitochondrial		145	Unreviewed	Mitochondrion outer membrane	leukotriene metabolic process | lipid metabolic process	glutathione peroxidase activity | glutathione transferase activity | leukotriene-C4 synthase activity	endoplasmic reticulum | mitochondrial outer membrane | nuclear envelope	Lipid metabolism | Lipoprotein | Lyase | Membrane | Mitochondrion | Mitochondrion outer membrane | Oxidoreductase | Palmitate | Transferase | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A0K8RN05	Cytidine deaminase		179	Unreviewed		nucleobase-containing small molecule metabolic process | pyrimidine-containing compound metabolic process	cytidine deaminase activity | identical protein binding | zinc ion binding	cytosol	Hydrolase | Metal-binding | Zinc		This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
Ixodes ricinus	34613	A0A0K8RMR7	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial		653	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, succinate to ubiquinone | tricarboxylic acid cycle	electron transfer activity | flavin adenine dinucleotide binding | succinate dehydrogenase (quinone) activity	mitochondrial inner membrane	Electron transport | FAD | Flavoprotein | Membrane | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Transit peptide | Transport | Tricarboxylic acid cycle		Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)
Ixodes ricinus	34613	A0A0K8RMG3	Golgi SNAP receptor complex member 2		213	Unreviewed	Endoplasmic reticulum membrane | Golgi apparatus, cis-Golgi network membrane	intra-Golgi vesicle-mediated transport | protein transport | vesicle fusion	SNAP receptor activity | SNARE binding	endoplasmic reticulum membrane | ER to Golgi transport vesicle membrane | Golgi apparatus | late endosome membrane | SNARE complex	Acetylation | Coiled coil | Endoplasmic reticulum | Golgi apparatus | Membrane | Protein transport | Receptor | Transmembrane | Transmembrane helix | Transport		Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network
Ixodes ricinus	34613	A0A0K8RIS1	Adenylosuccinate synthetase		450	Unreviewed	Cytoplasm	'de novo' AMP biosynthetic process | IMP metabolic process	adenylosuccinate synthase activity | GTP binding | magnesium ion binding	cytoplasm	Cytoplasm | GTP-binding | Ligase | Magnesium | Metal-binding | Nucleotide-binding | Purine biosynthesis		Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP
Ixodes ricinus	34613	A0A0K8RM59	Vesicle-associated membrane protein 7		218	Unreviewed	Cytoplasmic vesicle, phagosome membrane | Cytoplasmic vesicle, secretory vesicle membrane | Endoplasmic reticulum membrane | Golgi apparatus, trans-Golgi network membrane | Late endosome membrane | Lysosome membrane	exocytosis | protein transport | vesicle fusion	SNAP receptor activity | SNARE binding	endoplasmic reticulum membrane | Golgi apparatus | late endosome membrane | lysosomal membrane | phagocytic vesicle membrane | SNARE complex | transport vesicle membrane	Coiled coil | Membrane | Protein transport | Transmembrane | Transmembrane helix | Transport		
Ixodes ricinus	34613	A0A0K8RLL0	N-terminal amino-acid N(alpha)-acetyltransferase NatA		185	Unreviewed			protein N-terminal-serine acetyltransferase activity | protein-N-terminal-glutamate acetyltransferase activity	NatA complex	Acyltransferase | Transferase		
Ixodes ricinus	34613	A0A0K8RL87	Sodium/potassium-transporting ATPase subunit alpha		924	Unreviewed	Cell membrane	intracellular potassium ion homeostasis | intracellular sodium ion homeostasis | potassium ion import across plasma membrane | proton transmembrane transport | sodium ion export across plasma membrane	ATP binding | ATP hydrolysis activity | metal ion binding | P-type sodium:potassium-exchanging transporter activity	plasma membrane	ATP-binding | Cell membrane | Ion transport | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Potassium | Potassium transport | Sodium | Sodium transport | Sodium/potassium transport | Translocase | Transmembrane | Transmembrane helix | Transport		This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients
Ixodes ricinus	34613	A0A0K8RL29	N-terminal methionine N(alpha)-acetyltransferase NatE		175	Unreviewed	Cytoplasm	mitotic sister chromatid cohesion	protein N-terminal-methionine acetyltransferase activity	NatA complex	Acyltransferase | Cytoplasm | Transferase		
Ixodes ricinus	34613	A0A0K8RKW2	E3 ubiquitin-protein ligase		271	Unreviewed	Cytoplasm, cytosol	protein autoubiquitination | ubiquitin-dependent protein catabolic process | Wnt signaling pathway	ligase activity | poly-ADP-D-ribose binding | ubiquitin protein ligase activity | zinc ion binding	cytosol | nucleus	Cytoplasm | Ligase | Metal-binding | Transferase | Ubl conjugation pathway | Wnt signaling pathway | Zinc | Zinc-finger		E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation
Ixodes ricinus	34613	A0A0K8RKS1	Methyltransferase HEMK2		210	Unreviewed	Nucleus	methylation	nucleic acid binding | protein-glutamine N-methyltransferase activity	eRF1 methyltransferase complex | nucleus	Methyltransferase | Nucleus | S-adenosyl-L-methionine | Transferase		Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT
Ixodes ricinus	34613	A0A0K8RKJ7	Ras-related protein Rab-14		307	Unreviewed	Cytoplasmic vesicle | Early endosome membrane | Golgi apparatus, trans-Golgi network membrane | Recycling endosome	defense response to bacterium | endocytic recycling | Golgi to endosome transport | phagosome maturation | protein transport	G protein activity | GTP binding	cytosol | early endosome membrane | phagocytic vesicle | recycling endosome | trans-Golgi network	Acetylation | Cytoplasmic vesicle | Endosome | Golgi apparatus | GTP-binding | Hydrolase | Lipoprotein | Membrane | Methylation | Nucleotide-binding | Prenylation | Protein transport | Transmembrane | Transmembrane helix | Transport		
Ixodes ricinus	34613	A0A0K8RKJ5	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase		310	Unreviewed	Cytoplasm | Nucleus	cell division | cytoplasmic translation | tRNA nucleoside ribose methylation	tRNA (guanosine(34)-2'-O)-methyltransferase activity	cytoplasm | nucleus	Cell cycle | Cell division | Cytoplasm | Methyltransferase | S-adenosyl-L-methionine | Transferase | tRNA processing		Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs
Ixodes ricinus	34613	A0A0K8RKI9	Aspartate aminotransferase		407	Unreviewed	Cytoplasm	aspartate biosynthetic process	2-aminobutanoate transaminase activity | L-aspartate:2-oxoglutarate aminotransferase activity | L-cysteine transaminase activity | pyridoxal phosphate binding	cytosol	Aminotransferase | Cytoplasm | Pyridoxal phosphate | Transferase		
Ixodes ricinus	34613	A0A0K8RK63	Purine nucleoside phosphorylase		296	Unreviewed		nucleoside metabolic process	guanosine phosphorylase activity | purine-nucleoside phosphorylase activity	cytoplasm	Glycosyltransferase | Transferase		The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Ixodes ricinus	34613	A0A0K8RK22	Ketimine reductase mu-crystallin		318	Unreviewed			hormone binding | pyrroline-2-carboxylate reductase activity | thiomorpholine-carboxylate dehydrogenase activity	cytoplasm			
Ixodes ricinus	34613	A0A0K8RJM0	Glycerol-3-phosphate dehydrogenase [NAD(+)]		350	Unreviewed		carbohydrate metabolic process | glycerol-3-phosphate catabolic process | glycerophospholipid metabolic process	glycerol-3-phosphate dehydrogenase (NAD+) activity | NAD binding | protein homodimerization activity	cytosol	NAD | Oxidoreductase		
Ixodes ricinus	34613	A0A0K8RJD6	Isovaleryl-CoA dehydrogenase, mitochondrial		423	Unreviewed	Mitochondrion	L-leucine catabolic process	3-methylbutanoyl-CoA dehydrogenase activity | flavin adenine dinucleotide binding	mitochondrion	FAD | Flavoprotein | Mitochondrion | Oxidoreductase | Transit peptide		Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA
Ixodes ricinus	34613	A0A0K8RJ82	Homogentisate 1,2-dioxygenase		445	Unreviewed		L-phenylalanine catabolic process | L-tyrosine catabolic process	homogentisate 1,2-dioxygenase activity | metal ion binding	cytoplasm	Dioxygenase | Iron | Metal-binding | Oxidoreductase | Phenylalanine catabolism | Tyrosine catabolism		
Ixodes ricinus	34613	A0A0K8RM36	Elongin-B		119	Unreviewed	Nucleus	transcription elongation by RNA polymerase II	translation elongation factor activity	elongin complex | VCB complex	Acetylation | Elongation factor | Nucleus | Phosphoprotein | Protein biosynthesis | Transcription | Transcription regulation | Ubl conjugation pathway		SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells
Ixodes ricinus	34613	A0A131XV35	Serine/threonine-protein kinase PLK		592	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Cytoplasm, cytoskeleton, spindle | Midbody | Nucleus	cell division | mitotic spindle organization	ATP binding | protein serine kinase activity | protein serine/threonine kinase activity	centrosome | cytoplasm | kinetochore | midbody | nucleus | spindle pole	ATP-binding | Cell cycle | Cell division | Cytoplasm | Cytoskeleton | Kinase | Mitosis | Nucleotide-binding | Nucleus | Phosphoprotein | Repeat | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A131XVB0	adenylate cyclase		1191	Unreviewed	Membrane	adenylate cyclase-activating G protein-coupled receptor signaling pathway | cAMP biosynthetic process | intracellular signal transduction	adenylate cyclase activity | ATP binding | metal ion binding	plasma membrane	ATP-binding | cAMP biosynthesis | Glycoprotein | Lyase | Magnesium | Manganese | Membrane | Metal-binding | Nucleotide-binding | Repeat | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A131XV48	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase		348	Unreviewed	Golgi apparatus membrane	carbohydrate metabolic process | chondroitin sulfate proteoglycan biosynthetic process	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity | metal ion binding	Golgi membrane	Disulfide bond | Glycoprotein | Golgi apparatus | Manganese | Membrane | Metal-binding | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A131Y053	RING-type E3 ubiquitin-protein ligase PPIL2		512	Unreviewed	Nucleus	mRNA processing | protein folding | protein polyubiquitination | RNA splicing	peptidyl-prolyl cis-trans isomerase activity | ubiquitin protein ligase activity	catalytic step 2 spliceosome	Acetylation | Coiled coil | Isomerase | Isopeptide bond | mRNA processing | mRNA splicing | Nucleus | Spliceosome | Transferase | Ubl conjugation | Ubl conjugation pathway		Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs
Ixodes ricinus	34613	A0A131Y027	DNA-directed RNA polymerase subunit beta		1141	Unreviewed	Cytoplasm, cytosol | Nucleus	defense response to virus | innate immune response | transcription by RNA polymerase III	DNA binding | DNA-directed RNA polymerase activity | metal ion binding | ribonucleoside binding	cytosol | DNA-directed RNA polymerase complex | nucleus	Antiviral defense | Cytoplasm | DNA-directed RNA polymerase | Immunity | Innate immunity | Magnesium | Metal-binding | Nucleotidyltransferase | Nucleus | Transcription | Transferase | Zinc		DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Ixodes ricinus	34613	A0A131Y014	CTP synthase		686	Unreviewed		'de novo' CTP biosynthetic process | pyrimidine nucleobase biosynthetic process	ATP binding | CTP synthase activity | identical protein binding | lyase activity	cytoophidium | cytoplasm	ATP-binding | Glutamine amidotransferase | Ligase | Lyase | Nucleotide-binding | Pyrimidine biosynthesis		Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides
Ixodes ricinus	34613	A0A131Y010	Adenosine kinase		348	Unreviewed	Nucleus	AMP salvage | purine nucleobase metabolic process | purine ribonucleoside salvage	adenosine kinase activity | ATP binding	cytosol | nucleus	ATP-binding | Kinase | Magnesium | Nucleotide-binding | Nucleus | Purine salvage | Transferase		ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives
Ixodes ricinus	34613	A0A131XZY0	thioredoxin-disulfide reductase (NADPH)		521	Unreviewed		cell redox homeostasis | cellular response to oxidative stress | glutathione metabolic process	flavin adenine dinucleotide binding | glutathione-disulfide reductase (NADPH) activity | thioredoxin-disulfide reductase (NADPH) activity	cytosol | mitochondrion	Disulfide bond | FAD | Flavoprotein | NAD | NADP | Nucleotide-binding | Oxidoreductase | Redox-active center		Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms
Ixodes ricinus	34613	A0A131XZX8	serine--tRNA ligase		498	Unreviewed	Cytoplasm	seryl-tRNA aminoacylation	ATP binding | serine-tRNA ligase activity	cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Cytoplasm | Ligase | Nucleotide-binding | Protein biosynthesis		
Ixodes ricinus	34613	A0A131XZX0	Cytochrome c1, heme protein, mitochondrial		310	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	electron transfer activity | heme binding | metal ion binding	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
Ixodes ricinus	34613	A0A131XZW8	Probable D-lactate dehydrogenase, mitochondrial		492	Unreviewed	Mitochondrion | Peroxisome	lactate catabolic process	D-lactate dehydrogenase (cytochrome) activity | D-lactate dehydrogenase (NAD+) activity | FAD binding	mitochondrion | peroxisome	Acetylation | FAD | Flavoprotein | Mitochondrion | Oxidoreductase | Peroxisome | Transit peptide		Involved in D-lactate, but not L-lactate catabolic process
Ixodes ricinus	34613	A0A131XZW7	Serine hydroxymethyltransferase		468	Unreviewed		glycine biosynthetic process from serine | methylation | tetrahydrofolate interconversion	glycine hydroxymethyltransferase activity | methyltransferase activity | pyridoxal phosphate binding	mitochondrion | nucleus	Methyltransferase | One-carbon metabolism | Pyridoxal phosphate | Transferase		Interconversion of serine and glycine
Ixodes ricinus	34613	A0A131XZU9	(3R)-3-hydroxyacyl-CoA dehydrogenase		247	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	A0A131XZU2	dolichyl-phosphate-mannose--protein mannosyltransferase		766	Unreviewed	Endoplasmic reticulum | Membrane	endoplasmic reticulum unfolded protein response	dolichyl-phosphate-mannose-protein mannosyltransferase activity	endoplasmic reticulum | membrane	Coiled coil | Endoplasmic reticulum | Membrane | Repeat | TPR repeat | Transferase | Transmembrane | Transmembrane helix		Transfers mannosyl residues to the hydroxyl group of serine or threonine residues
Ixodes ricinus	34613	A0A131XZT1	Ubiquitin carboxyl-terminal hydrolase		353	Unreviewed		protein K48-linked deubiquitination | proteolysis	cysteine-type carboxypeptidase activity | cysteine-type deubiquitinase activity | histone deubiquitinase activity | K48-linked deubiquitinase activity | K48-linked polyubiquitin modification-dependent protein binding	cell periphery | cytosol	Hydrolase | Protease | Thiol protease | Ubl conjugation pathway		Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover
Ixodes ricinus	34613	A0A131XZR7	DNA repair protein RAD50		1317	Unreviewed	Chromosome | Nucleus	chromosome organization involved in meiotic cell cycle | double-strand break repair | telomere maintenance via recombination | telomere maintenance via telomerase	ATP binding | ATP hydrolysis activity | double-stranded telomeric DNA binding | G-quadruplex DNA binding | metal ion binding | single-stranded telomeric DNA binding	condensed nuclear chromosome | Mre11 complex	ATP-binding | Cell cycle | Chromosome | Coiled coil | DNA damage | DNA repair | Hydrolase | Magnesium | Meiosis | Metal-binding | Nucleotide-binding | Nucleus | Zinc		
Ixodes ricinus	34613	A0A131XZR5	Endoplasmic reticulum transmembrane helix translocase		1177	Unreviewed	Endoplasmic reticulum membrane	intracellular calcium ion homeostasis | protein transport	ATP binding | ATP hydrolysis activity | ATPase-coupled monoatomic cation transmembrane transporter activity | membrane protein dislocase activity | metal ion binding | P-type ion transporter activity	endoplasmic reticulum membrane	ATP-binding | Endoplasmic reticulum | Glycoprotein | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Protein transport | Translocase | Transmembrane | Transmembrane helix | Transport		Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains
Ixodes ricinus	34613	A0A131XZP9	Kinesin-like protein		979	Unreviewed	Cytoplasm, cytoskeleton	anterograde axonal transport of mitochondrion | establishment or maintenance of microtubule cytoskeleton polarity | female gamete generation | nuclear migration | synaptic vesicle transport	ATP binding | microtubule binding | microtubule motor activity	axon cytoplasm | kinesin complex | microtubule	ATP-binding | Coiled coil | Cytoplasm | Cytoskeleton | Microtubule | Motor protein | Nucleotide-binding		
Ixodes ricinus	34613	A0A131XZL0	(3R)-3-hydroxyacyl-CoA dehydrogenase		255	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	A0A131XZJ4	Translin-associated protein X		290	Unreviewed	Cytoplasm, perinuclear region | Golgi apparatus | Nucleus	cell differentiation | spermatogenesis	metal ion binding | sequence-specific DNA binding	Golgi apparatus | nucleus | perinuclear region of cytoplasm	Cytoplasm | Developmental protein | Differentiation | DNA-binding | Golgi apparatus | Isopeptide bond | Magnesium | Metal-binding | Nucleus | Spermatogenesis | Ubl conjugation		Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis
Ixodes ricinus	34613	A0A131XZI7	Fumarylacetoacetase		458	Unreviewed		homogentisate catabolic process | L-phenylalanine catabolic process | L-tyrosine catabolic process	fumarylacetoacetase activity | metal ion binding		Calcium | Hydrolase | Magnesium | Metal-binding | Phenylalanine catabolism | Signal | Tyrosine catabolism		
Ixodes ricinus	34613	A0A131XZG9	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2		649	Unreviewed	Cytoplasm | Nucleus	7-methylguanosine mRNA capping | methylation	methyltransferase cap1 activity | methyltransferase cap2 activity	cytoplasm | nucleus	Cytoplasm | Methyltransferase | mRNA processing | Nucleus | S-adenosyl-L-methionine | Transferase		
Ixodes ricinus	34613	A0A131XZG1	Putative peptidylglycine alpha-amidating monooxygenase		482	Unreviewed		peptide metabolic process	copper ion binding | peptidylamidoglycolate lyase activity | peptidylglycine monooxygenase activity	extracellular region | membrane	Copper | Disulfide bond | Glycoprotein | Lyase | Metal-binding | Monooxygenase | Multifunctional enzyme | Oxidoreductase | Repeat | Signal		
Ixodes ricinus	34613	A0A131XZG0	adenylate cyclase		1026	Unreviewed	Membrane	adenylate cyclase-activating G protein-coupled receptor signaling pathway | cAMP biosynthetic process | intracellular signal transduction	adenylate cyclase activity | ATP binding | metal ion binding	plasma membrane	ATP-binding | cAMP biosynthesis | Glycoprotein | Lyase | Magnesium | Manganese | Membrane | Metal-binding | Nucleotide-binding | Repeat | Signal | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A131XZC5	Tissue-resident T-cell transcription regulator protein ZNF683		847	Unreviewed	Nucleus	adaptive immune response | cell fate commitment | innate immune response | regulation of immune system process | regulation of multicellular organismal process	DNA-binding transcription repressor activity, RNA polymerase II-specific | N-methyltransferase activity | protein methyltransferase activity | RNA polymerase II cis-regulatory region sequence-specific DNA binding | S-adenosylmethionine-dependent methyltransferase activity | zinc ion binding	cytoplasm | nucleus	Adaptive immunity | DNA-binding | Immunity | Innate immunity | Metal-binding | Nucleus | Repeat | Transcription | Transcription regulation | Zinc | Zinc-finger		
Ixodes ricinus	34613	A0A131XZC3	DNA ligase 4		889	Unreviewed	Nucleus	DNA biosynthetic process | DNA recombination | double-strand break repair via nonhomologous end joining | nucleotide-excision repair, DNA gap filling	ATP binding | DNA binding | DNA ligase (ATP) activity | metal ion binding	DNA ligase IV complex | DNA-dependent protein kinase-DNA ligase 4 complex	ATP-binding | DNA damage | DNA recombination | DNA repair | Ligase | Magnesium | Metal-binding | Nucleotide-binding | Nucleus | Repeat		
Ixodes ricinus	34613	A0A131XZB2	glutaminase		545	Unreviewed	Target cell membrane	exocytosis | glutamate biosynthetic process | L-glutamine catabolic process	glutaminase activity	host cell presynaptic membrane | other organism cell membrane	ANK repeat | Exocytosis | Hydrolase | Membrane | Neurotoxin | Presynaptic neurotoxin | Repeat | Target cell membrane | Target membrane | Toxin		
Ixodes ricinus	34613	A0A131XZB1	succinate dehydrogenase		613	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, succinate to ubiquinone | tricarboxylic acid cycle	electron transfer activity | flavin adenine dinucleotide binding | succinate dehydrogenase (quinone) activity	mitochondrial inner membrane	Electron transport | FAD | Flavoprotein | Membrane | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Transit peptide | Transport | Tricarboxylic acid cycle		
Ixodes ricinus	34613	A0A131XZA1	DNA topoisomerase I		906	Unreviewed		chromosome segregation | DNA replication | DNA topological change	DNA binding | DNA topoisomerase type I (single strand cut, ATP-independent) activity	chromosome | nucleolus	Coiled coil | DNA-binding | Isomerase | Topoisomerase		Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Ixodes ricinus	34613	A0A131XZ92	DNA repair protein RAD51 homolog		352	Unreviewed	Nucleus	chromosome organization involved in meiotic cell cycle | DNA recombinase assembly | DNA strand invasion | mitotic recombination | mitotic recombination-dependent replication fork processing | reciprocal meiotic recombination	ATP binding | ATP-dependent DNA damage sensor activity | DNA strand exchange activity | double-stranded DNA binding | single-stranded DNA binding	condensed nuclear chromosome	ATP-binding | DNA damage | DNA recombination | DNA repair | DNA-binding | Nucleotide-binding | Nucleus		Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA
Ixodes ricinus	34613	A0A131Y064	Adenylate kinase		252	Unreviewed	Cytoplasm, cytosol | Mitochondrion intermembrane space	ADP biosynthetic process | AMP metabolic process | ATP metabolic process	AMP kinase activity | ATP binding	cytosol | mitochondrial intermembrane space	ATP-binding | Cytoplasm | Kinase | Mitochondrion | Nucleotide-binding | Transferase		Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways
Ixodes ricinus	34613	A0A131Y0F0	Pyridoxal kinase		312	Unreviewed		pyridoxal 5'-phosphate salvage	ATP binding | pyridoxal kinase activity	cytosol	ATP-binding | Kinase | Nucleotide-binding | Transferase		
Ixodes ricinus	34613	A0A131Y0F2	Glycerol-3-phosphate dehydrogenase [NAD(+)]		360	Unreviewed		carbohydrate metabolic process | glycerol-3-phosphate catabolic process | glycerophospholipid metabolic process	glycerol-3-phosphate dehydrogenase (NAD+) activity | NAD binding | protein homodimerization activity	cytosol	NAD | Oxidoreductase		
Ixodes ricinus	34613	A0A131Y0F6	Phosphoglycerate kinase		453	Unreviewed		gluconeogenesis | glycolytic process	ADP binding | ATP binding | metal ion binding | phosphoglycerate kinase activity	cytosol	ATP-binding | Glycolysis | Kinase | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Transferase | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A0K8RBC0	Methionine aminopeptidase 2		474	Unreviewed	Cytoplasm	proteolysis	initiator methionyl aminopeptidase activity | metal ion binding | metalloaminopeptidase activity	cytoplasm	Aminopeptidase | Cytoplasm | Hydrolase | Metal-binding | Protease		Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)
Ixodes ricinus	34613	A0A131Y1L7	Phospholipid-transporting ATPase		1094	Unreviewed	Endomembrane system | Golgi apparatus | Membrane	phospholipid translocation	ATP binding | ATP hydrolysis activity | magnesium ion binding | phosphatidylserine floppase activity	plasma membrane | trans-Golgi network	ATP-binding | Golgi apparatus | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Translocase | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A131Y1J2	(3R)-3-hydroxyacyl-CoA dehydrogenase		229	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	A0A131Y1I1	Putative molybdopterin biosynthesis protein		500	Unreviewed		establishment of synaptic specificity at neuromuscular junction | gamma-aminobutyric acid receptor clustering | glycine receptor clustering | Mo-molybdopterin cofactor biosynthetic process | postsynaptic neurotransmitter receptor diffusion trapping	ATP binding | metal ion binding | molybdopterin adenylyltransferase activity | molybdopterin molybdotransferase activity	cytosol | dendrite | postsynaptic specialization membrane	Magnesium | Metal-binding | Molybdenum | Molybdenum cofactor biosynthesis | Transferase		Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released
Ixodes ricinus	34613	A0A131Y1F5	RNA cytidine acetyltransferase		992	Unreviewed	Nucleus, nucleolus	rRNA acetylation involved in maturation of SSU-rRNA | tRNA acetylation	18S rRNA cytidine N-acetyltransferase activity | ATP binding | tRNA binding | tRNA cytidine N4-acetyltransferase activity	90S preribosome | nucleolus	Acyltransferase | ATP-binding | Membrane | Nucleotide-binding | Nucleus | rRNA processing | Transferase | Transmembrane | Transmembrane helix | tRNA processing		RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation
Ixodes ricinus	34613	A0A131Y1F0	Ketimine reductase mu-crystallin		317	Unreviewed			hormone binding | pyrroline-2-carboxylate reductase activity | thiomorpholine-carboxylate dehydrogenase activity	cytoplasm			
Ixodes ricinus	34613	A0A131Y1E3	(3R)-3-hydroxyacyl-CoA dehydrogenase		247	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	A0A131Y1E2	Ribose-phosphate pyrophosphokinase 2		342	Unreviewed		5-phosphoribose 1-diphosphate biosynthetic process | purine nucleotide biosynthetic process | ribonucleoside monophosphate biosynthetic process	ATP binding | kinase activity | magnesium ion binding | ribose phosphate diphosphokinase activity	cytoplasm | ribose phosphate diphosphokinase complex	ATP-binding | Kinase | Magnesium | Metal-binding | Nucleotide biosynthesis | Nucleotide-binding | Transferase		Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis
Ixodes ricinus	34613	A0A131Y1D3	ATP-dependent DNA helicase 2 subunit 1		577	Unreviewed	Nucleus	DNA recombination | double-strand break repair via nonhomologous end joining | telomere maintenance	ATP binding | damaged DNA binding | DNA helicase activity | double-stranded DNA binding | hydrolase activity | kinase activity | telomeric DNA binding	Ku70:Ku80 complex	ATP-binding | DNA damage | DNA recombination | DNA repair | DNA-binding | Helicase | Hydrolase | Kinase | Nucleotide-binding | Nucleus | Transferase		
Ixodes ricinus	34613	A0A131Y1B9	UMP-CMP kinase		241	Unreviewed	Cytoplasm | Nucleus	'de novo' pyrimidine nucleobase biosynthetic process | pyrimidine nucleotide biosynthetic process	ATP binding | CMP kinase activity | dCMP kinase activity | UMP kinase activity	cytoplasm | nucleus	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Nucleus | Pyrimidine biosynthesis | Transferase		Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors
Ixodes ricinus	34613	A0A131Y1A4	RNA helicase aquarius		1462	Unreviewed	Nucleus, nucleoplasm	mRNA splicing, via spliceosome	ATP binding | hydrolase activity | mRNA binding | RNA helicase activity	catalytic step 2 spliceosome | nucleoplasm	Acetylation | ATP-binding | Helicase | Hydrolase | mRNA processing | mRNA splicing | Nucleotide-binding | Nucleus | RNA-binding | Spliceosome		Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro)
Ixodes ricinus	34613	A0A131Y187	Inosine-5'-monophosphate dehydrogenase		512	Unreviewed	Cytoplasm	GMP biosynthetic process | GTP biosynthetic process	IMP dehydrogenase activity | metal ion binding | nucleotide binding	cytoplasm	CBS domain | Cytoplasm | GMP biosynthesis | Metal-binding | NAD | Oxidoreductase | Potassium | Purine biosynthesis		Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
Ixodes ricinus	34613	A0A131Y176	(3R)-3-hydroxyacyl-CoA dehydrogenase		247	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	A0A131XZ91	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]		548	Unreviewed		mRNA processing	flavin adenine dinucleotide binding | mRNA dihydrouridine synthase activity | RNA binding | tRNA-dihydrouridine47 synthase activity | zinc ion binding		Flavoprotein | FMN | Metal-binding | mRNA processing | NAD | NADP | Oxidoreductase | Repeat | tRNA processing | Zinc | Zinc-finger		Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation
Ixodes ricinus	34613	A0A131Y161	Sialin		499	Unreviewed	Basolateral cell membrane | Cytoplasmic vesicle, secretory vesicle membrane | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane | Lysosome membrane	carboxylic acid transport | monoatomic anion transport	symporter activity	basolateral plasma membrane | lysosomal membrane | synaptic vesicle membrane	Cell membrane | Cytoplasmic vesicle | Glycoprotein | Lysosome | Membrane | Symport | Synapse | Transmembrane | Transmembrane helix | Transport		Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties
Ixodes ricinus	34613	A0A131Y127	Putative rRNA methyltransferase		820	Unreviewed	Nucleus, nucleolus	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rRNA (guanine) methyltransferase activity | rRNA (uridine-2'-O-)-methyltransferase activity	nucleolus | preribosome, large subunit precursor	Coiled coil | Methyltransferase | Nucleus | Ribosome biogenesis | rRNA processing | S-adenosyl-L-methionine | Transferase		Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits
Ixodes ricinus	34613	A0A131Y116	Mitochondrial 2-oxodicarboxylate carrier		306	Unreviewed	Mitochondrion inner membrane	transmembrane transport		mitochondrial inner membrane	Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle
Ixodes ricinus	34613	A0A131Y0Z8	ATP-citrate synthase		1080	Unreviewed	Cytoplasm, cytosol	acetyl-CoA biosynthetic process | citrate metabolic process | fatty acid biosynthetic process	ATP binding | ATP citrate synthase activity | lyase activity | metal ion binding	cytosol	Acetylation | ATP-binding | Cytoplasm | Isopeptide bond | Lipid biosynthesis | Lipid metabolism | Lyase | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Transferase | Ubl conjugation		Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism
Ixodes ricinus	34613	A0A131Y0Y1	Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial		463	Unreviewed	Mitochondrion	glutamyl-tRNA aminoacylation	ATP binding | glutamate-tRNA ligase activity | glutamate-tRNA(Gln) ligase activity | tRNA binding | zinc ion binding	mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Nucleotide-binding | Protein biosynthesis		
Ixodes ricinus	34613	A0A131Y0U8	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase		1083	Unreviewed	Cytoplasm, cytosol	inositol metabolic process | inositol phosphate biosynthetic process	5-diphosphoinositol pentakisphosphate 1-kinase activity | ATP binding | inositol hexakisphosphate 1-kinase activity | phosphatase activity	cytosol	ATP-binding | Cytoplasm | Kinase | Membrane | Nucleotide-binding | Transferase | Transmembrane | Transmembrane helix		Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4
Ixodes ricinus	34613	A0A131Y0U7	ADP/ATP translocase		299	Unreviewed	Membrane | Mitochondrion inner membrane	mitochondrial ADP transmembrane transport | mitochondrial ATP transmembrane transport | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ATP:ADP antiporter activity	mitochondrial inner membrane	Antiport | Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane
Ixodes ricinus	34613	A0A131Y0S1	(3R)-3-hydroxyacyl-CoA dehydrogenase		248	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	A0A131Y0N4	non-specific serine/threonine protein kinase		838	Unreviewed	Cytoplasm	actomyosin structure organization | negative regulation of protein localization to nucleus	ATP binding | metal ion binding | protein serine/threonine kinase activity	cell periphery | cytoplasm | cytoskeleton	ATP-binding | Cytoplasm | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A131Y0J9	Katanin p80 WD40 repeat-containing subunit B1	KATNB1	792	Unreviewed	Cytoplasm, cytoskeleton | Cytoplasm | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Cytoplasm, cytoskeleton, spindle pole | Cytoplasm, cytoskeleton, spindle	cell division | microtubule depolymerization | microtubule severing	microtubule binding	centrosome | cytoplasm | katanin complex | microtubule | spindle pole	Cell cycle | Cell division | Cytoplasm | Cytoskeleton | Microtubule | Mitosis | Repeat | WD repeat		Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation
Ixodes ricinus	34613	A0A131Y0J6	G/T mismatch-specific thymine DNA glycosylase		383	Unreviewed	Nucleus	base-excision repair, AP site formation | epigenetic regulation of gene expression	DNA binding | G/T mismatch-specific thymine-DNA glycosylase activity | SUMO binding | uracil DNA N-glycosylase activity	nucleoplasm	Activator | Chromatin regulator | DNA damage | DNA repair | Hydrolase | Isopeptide bond | Nucleus | Transcription | Transcription regulation | Ubl conjugation		
Ixodes ricinus	34613	A0A131Y0I5	Sialin		532	Unreviewed	Basolateral cell membrane | Cytoplasmic vesicle, secretory vesicle membrane | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane | Lysosome membrane	carboxylic acid transport | monoatomic anion transport	symporter activity	basolateral plasma membrane | lysosomal membrane | synaptic vesicle membrane	Cell membrane | Cytoplasmic vesicle | Glycoprotein | Lysosome | Membrane | Symport | Synapse | Transmembrane | Transmembrane helix | Transport		Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties
Ixodes ricinus	34613	A0A131Y0I0	Mitochondrial 2-oxodicarboxylate carrier		304	Unreviewed	Mitochondrion inner membrane			mitochondrial inner membrane	Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle
Ixodes ricinus	34613	A0A131Y0G2	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial		477	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	4 iron, 4 sulfur cluster binding | FMN binding | metal ion binding | NAD binding | NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	4Fe-4S | Electron transport | Flavoprotein | FMN | Iron | Iron-sulfur | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Transit peptide | Translocase | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I
Ixodes ricinus	34613	A0A131Y156	(3R)-3-hydroxyacyl-CoA dehydrogenase		231	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	A0A131XV41	Citramalyl-CoA lyase, mitochondrial		365	Unreviewed	Mitochondrion	regulation of cobalamin metabolic process	(S)-citramalyl-CoA lyase activity | hydrolase activity | malate synthase activity | metal ion binding	mitochondrion	Acetylation | Hydrolase | Lyase | Magnesium | Metal-binding | Mitochondrion | Transferase | Transit peptide		Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro
Ixodes ricinus	34613	A0A131XZ82	Phosphomannomutase		253	Unreviewed	Cytoplasm	GDP-mannose biosynthetic process | mannose metabolic process | protein N-linked glycosylation	metal ion binding | phosphomannomutase activity	cytosol	Cytoplasm | Isomerase | Magnesium | Metal-binding		Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions
Ixodes ricinus	34613	A0A131XZ60	DNA topoisomerase I		778	Unreviewed		chromosome segregation | DNA replication | DNA topological change	DNA binding | DNA topoisomerase type I (single strand cut, ATP-independent) activity	chromosome | nucleolus	Coiled coil | DNA-binding | Isomerase | Topoisomerase		Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Ixodes ricinus	34613	A0A131XXA1	DNA topoisomerase		705	Unreviewed	Mitochondrion matrix	DNA recombination | DNA repair | DNA topological change	DNA binding | DNA topoisomerase type I (single strand cut, ATP-independent) activity | zinc ion binding	mitochondrial matrix | nucleoplasm | RecQ family helicase-topoisomerase III complex	DNA-binding | Isomerase | Magnesium | Metal-binding | Mitochondrion | Repeat | Topoisomerase | Zinc | Zinc-finger		Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand
Ixodes ricinus	34613	A0A131XX74	cyclin-dependent kinase		316	Unreviewed		G1/S transition of mitotic cell cycle | regulation of G2/M transition of mitotic cell cycle | regulation of gene expression | signal transduction	ATP binding | cyclin binding | cyclin-dependent protein serine/threonine kinase activity	cyclin-dependent protein kinase holoenzyme complex | cytoplasm | nucleus	ATP-binding | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A131XX59	Isocitrate dehydrogenase [NADP]		445	Unreviewed		glyoxylate cycle | isocitrate metabolic process | NADP+ metabolic process | tricarboxylic acid cycle	isocitrate dehydrogenase (NADP+) activity | magnesium ion binding | NAD binding	mitochondrion	Glyoxylate bypass | Magnesium | Manganese | Metal-binding | NADP | Oxidoreductase | Tricarboxylic acid cycle		
Ixodes ricinus	34613	A0A131XX10	Adenosine kinase		348	Unreviewed	Nucleus	AMP salvage | purine nucleobase metabolic process | purine ribonucleoside salvage	adenosine kinase activity | ATP binding	cytosol | nucleus	ATP-binding | Kinase | Magnesium | Nucleotide-binding | Nucleus | Purine salvage | Transferase		ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives
Ixodes ricinus	34613	A0A131XX00	Endonuclease III homolog	NTH1	326	Unreviewed	Nucleus | Mitochondrion	base-excision repair, AP site formation | nucleotide-excision repair	4 iron, 4 sulfur cluster binding | class I DNA-(apurinic or apyrimidinic site) endonuclease activity | DNA binding | metal ion binding | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	mitochondrion | nucleus	4Fe-4S | DNA damage | DNA repair | Endonuclease | Glycosidase | Hydrolase | Iron | Iron-sulfur | Lyase | Metal-binding | Mitochondrion | Nuclease | Nucleus | Transit peptide		Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines
Ixodes ricinus	34613	A0A131XWX0	Glutathione reductase		487	Unreviewed	Cytoplasm	cell redox homeostasis | cellular response to oxidative stress | glutathione metabolic process	flavin adenine dinucleotide binding | glutathione-disulfide reductase (NADPH) activity | NADP binding	cytosol | mitochondrion	Cytoplasm | Disulfide bond | FAD | Flavoprotein | NAD | NADP | Nucleotide-binding | Oxidoreductase | Redox-active center		Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol
Ixodes ricinus	34613	A0A131XWV9	Serine/threonine-protein kinase RIO3		557	Unreviewed	Cytoplasm	defense response to virus | innate immune response | ribosome biogenesis	ATP binding | metal ion binding | protein serine kinase activity | protein serine/threonine kinase activity	cytoplasm	Antiviral defense | ATP-binding | Cytoplasm | Immunity | Innate immunity | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Ribosome biogenesis | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A131XWV0	Tyrosine-protein kinase		713	Unreviewed	Endomembrane system | Target cell membrane	cell development | exocytosis | morphogenesis of an epithelium | neuron differentiation | positive regulation of cellular component organization | regulation of developmental process	ATP binding | non-membrane spanning protein tyrosine kinase activity | transmembrane receptor protein tyrosine kinase activity	endomembrane system | host cell presynaptic membrane | other organism cell membrane	ANK repeat | ATP-binding | Exocytosis | Kinase | Membrane | Neurotoxin | Nucleotide-binding | Presynaptic neurotoxin | SH2 domain | Target cell membrane | Target membrane | Toxin | Transferase | Tyrosine-protein kinase		
Ixodes ricinus	34613	A0A131XWQ9	Proton-coupled zinc antiporter SLC30A5		639	Unreviewed	Cytoplasmic vesicle, COPII-coated vesicle membrane | Cytoplasmic vesicle, secretory vesicle membrane | Golgi apparatus, Golgi stack membrane | Golgi apparatus, trans-Golgi network membrane	intracellular zinc ion homeostasis | zinc ion import into Golgi lumen	antiporter activity | metal ion binding | zinc ion transmembrane transporter activity	ER to Golgi transport vesicle membrane | Golgi cisterna membrane	Antiport | Golgi apparatus | Ion transport | Membrane | Metal-binding | Transmembrane | Transmembrane helix | Transport | Zinc | Zinc transport		
Ixodes ricinus	34613	A0A131XWM3	Phosphoinositide phospholipase C		1264	Unreviewed		cell development | phosphatidylinositol metabolic process | phosphatidylinositol-mediated signaling | phospholipid catabolic process | positive regulation of epithelial cell migration | release of sequestered calcium ion into cytosol	calcium ion binding | lyase activity | phosphatidylinositol-4,5-bisphosphate phospholipase C activity	ruffle membrane	Calcium | Disulfide bond | Hydrolase | Lipid degradation | Lipid metabolism | Lyase | Magnesium | Metal-binding | Phosphoprotein | Repeat | SH2 domain | SH3 domain | Transducer		
Ixodes ricinus	34613	A0A131XWH2	DNA polymerase		1158	Unreviewed	Nucleus	cellular response to stress | lagging strand elongation | leading strand elongation | mitotic DNA replication initiation	chromatin binding | DNA replication origin binding | DNA-directed DNA polymerase activity | nucleotide binding | single-stranded DNA binding | zinc ion binding	alpha DNA polymerase:primase complex	DNA replication | DNA-binding | DNA-directed DNA polymerase | Metal-binding | Nucleotidyltransferase | Nucleus | Transferase | Zinc | Zinc-finger		
Ixodes ricinus	34613	A0A131XWG1	Phosphodiesterase		717	Unreviewed		anesthesia-resistant memory | axon extension | chemical synaptic transmission | circadian rhythm | conditioned taste aversion | courtship behavior | nonassociative learning | olfactory learning | short-term memory | signal transduction | thermosensory behavior	3',5'-cyclic-nucleotide phosphodiesterase activity | metal ion binding	synapse	cAMP | Hydrolase | Metal-binding		Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Vital for female fertility. Required for learning/memory
Ixodes ricinus	34613	A0A131XWA5	protein acetyllysine N-acetyltransferase		611	Unreviewed	Nucleus		histone deacetylase activity, NAD-dependent | metal ion binding | NAD+ binding | p53 binding | transcription corepressor activity	nuclear inner membrane | nucleoplasm | rDNA heterochromatin	Metal-binding | NAD | Nucleus | Transferase | Zinc		
Ixodes ricinus	34613	A0A131XW58	Mitogen-activated protein kinase		488	Unreviewed	Cytoplasm | Nucleus	Wnt signaling pathway	ATP binding | MAP kinase activity | metal ion binding	cytoplasm | nucleus	ATP-binding | Cytoplasm | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Nucleus | Serine/threonine-protein kinase | Transferase | Wnt signaling pathway		Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T-cell division asymmetry. Component of the beta-catenin-lit-1 complex which promotes the phosphorylation, down-regulation and subcellular relocation of pop-1. Regulates plp-1 nuclear localization in embryos. Plays a role in male tail tip morphogenesis
Ixodes ricinus	34613	A0A131XW57	Mothers against decapentaplegic homolog		446	Unreviewed	Cytoplasm | Nucleus	anatomical structure morphogenesis | cell differentiation | post-embryonic development | regulation of developmental process | regulation of multicellular organismal process | regulation of transcription by RNA polymerase II | SMAD protein signal transduction	I-SMAD binding | metal ion binding | transcription regulator inhibitor activity	cytoplasm | heteromeric SMAD protein complex	Cytoplasm | Metal-binding | Nucleus | Receptor | Transcription | Transcription regulation | Zinc		
Ixodes ricinus	34613	A0A131XW48	Mothers against decapentaplegic homolog		417	Unreviewed	Cytoplasm | Nucleus	activin receptor signaling pathway | anatomical structure morphogenesis | cell differentiation | positive regulation of transcription by RNA polymerase II | post-embryonic development | regulation of developmental process | regulation of multicellular organismal process | SMAD protein signal transduction	DNA-binding transcription factor activity, RNA polymerase II-specific | I-SMAD binding | metal ion binding | RNA polymerase II cis-regulatory region sequence-specific DNA binding	cytoplasm | heteromeric SMAD protein complex	Cytoplasm | Metal-binding | Nucleus | Receptor | Transcription | Transcription regulation | Zinc		
Ixodes ricinus	34613	A0A131XW43	mRNA-capping enzyme		597	Unreviewed	Nucleus	7-methylguanosine mRNA capping	ATP binding | GTP binding | mRNA 5'-triphosphate monophosphatase activity | mRNA guanylyltransferase activity | phosphoprotein phosphatase activity | polynucleotide 5'-phosphatase activity	nucleus	GTP-binding | Hydrolase | mRNA capping | mRNA processing | Nucleotide-binding | Nucleotidyltransferase | Nucleus | Protein phosphatase | Transferase		Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate
Ixodes ricinus	34613	A0A131XW29	DNA ligase		891	Unreviewed	Nucleus	cell division | DNA biosynthetic process | DNA recombination | DNA repair | Okazaki fragment processing involved in mitotic DNA replication	ATP binding | DNA binding | DNA ligase (ATP) activity	mitochondrion | nucleus	ATP-binding | Cell cycle | Cell division | DNA damage | DNA recombination | DNA repair | DNA replication | Ligase | Nucleotide-binding | Nucleus		DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair
Ixodes ricinus	34613	A0A131XW28	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1		375	Unreviewed	Membrane		glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity | manganese ion binding | nucleotide binding	membrane	Disulfide bond | Glycoprotein | Glycosyltransferase | Manganese | Membrane | Metal-binding | Nucleotide-binding | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins
Ixodes ricinus	34613	A0A131XW07	Chromatin-remodeling ATPase INO80		1075	Unreviewed	Nucleus	chromatin remodeling | DNA repair	ATP binding | ATP hydrolysis activity | DNA binding | histone binding	Ino80 complex	ATP-binding | DNA damage | DNA repair | DNA-binding | Hydrolase | Nucleotide-binding | Nucleus		ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair
Ixodes ricinus	34613	A0A131XVU8	Ubiquitin-conjugating enzyme E2 S		194	Unreviewed		anaphase-promoting complex-dependent catabolic process | cell division | exit from mitosis	ATP binding | ligase activity | ubiquitin conjugating enzyme activity		ATP-binding | Cell cycle | Cell division | Ligase | Nucleotide-binding | Transferase | Ubl conjugation pathway		
Ixodes ricinus	34613	A0A131XVH7	Protein kinase domain-containing protein		291	Unreviewed	Nucleus	cell division | G2/M transition of mitotic cell cycle | mitotic G2 DNA damage checkpoint signaling | positive regulation of cell cycle process | positive regulation of meiotic cell cycle	ATP binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	nucleus	ATP-binding | Cell cycle | Cell division | Kinase | Mitosis | Nucleotide-binding | Nucleus | Phosphoprotein | Serine/threonine-protein kinase | Transferase		Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia
Ixodes ricinus	34613	A0A131XVG5	DNA replication licensing factor MCM7	MCM7	722	Unreviewed	Chromosome | Nucleus	DNA replication initiation | DNA strand elongation involved in DNA replication | double-strand break repair via break-induced replication	ATP binding | ATP hydrolysis activity | single-stranded DNA binding | single-stranded DNA helicase activity	chromosome | MCM complex | nucleus	ATP-binding | Cell cycle | Chromosome | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Ubl conjugation		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Ixodes ricinus	34613	A0A131XVF2	E3 ubiquitin-protein ligase RNF144B		362	Unreviewed	Cytoplasm | Mitochondrion membrane	apoptotic process | protein ubiquitination	ubiquitin protein ligase activity | zinc ion binding	mitochondrial membrane	Apoptosis | Cytoplasm | Membrane | Metal-binding | Mitochondrion | Repeat | Transferase | Transmembrane | Transmembrane helix | Ubl conjugation | Ubl conjugation pathway | Zinc | Zinc-finger		E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Plays a crucial role in maintaining the genomic stability by controlling the degradation of multiple proteins involved in mitotic progression and DNA damage. Regulates epithelial homeostasis by mediating degradation of CDKN1A and isoform 2 of TP63. Plays a regulatory role in innate immunity by negatively regulating IRF3 activation and IFN-beta production. Mechanistically, inhibits TBK1 phosphorylation and 'Lys-63'-linked polyubiquitination independently of its E3 ligase activity. Alternatively, promotes 'Lys-27' and 'Lys-33'-linked ubiquitination of IFIH1/MDA5, promoting selective autophagic degradation of IFIH1/MDA5 to inhibit antiviral response
Ixodes ricinus	34613	A0A131XVB8	RB1-inducible coiled-coil protein 1		1303	Unreviewed	Cytoplasm, cytosol | Lysosome | Nucleus | Preautophagosomal structure	autophagosome assembly | autophagy of mitochondrion | glycophagy | negative regulation of cell population proliferation | piecemeal microautophagy of the nucleus | protein transport | reticulophagy | ribophagy	DNA binding | molecular adaptor activity | protein kinase binding	Atg1/ULK1 kinase complex | cytosol | lysosome | nucleus | organelle membrane | phagophore assembly site membrane	Autophagy | Cell cycle | Coiled coil | Cytoplasm | DNA-binding | Lysosome | Nucleus | Phosphoprotein | Protein transport | Transcription | Transcription regulation | Transport		Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis
Ixodes ricinus	34613	A0A131XVA7	Short-chain specific acyl-CoA dehydrogenase, mitochondrial		397	Unreviewed		butyrate catabolic process | fatty acid beta-oxidation using acyl-CoA dehydrogenase	flavin adenine dinucleotide binding | short-chain fatty acyl-CoA dehydrogenase activity	mitochondrion	FAD | Flavoprotein | Oxidoreductase		Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains
Ixodes ricinus	34613	A0A131XV58	Mitogen-activated protein kinase kinase kinase 7		583	Unreviewed		immune response | JNK cascade | positive regulation of canonical NF-kappaB signal transduction | positive regulation of MAPK cascade | positive regulation of metabolic process | response to stress	ATP binding | enzyme binding | MAP kinase kinase kinase activity | metal ion binding		ATP-binding | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A131XXA4	U5 small nuclear ribonucleoprotein 200 kDa helicase		2143	Unreviewed	Nucleus	mRNA splicing, via spliceosome | resolution of meiotic recombination intermediates	ATP binding | DNA helicase activity | hydrolase activity | nucleic acid binding | RNA helicase activity	small nuclear ribonucleoprotein complex | spliceosomal complex	ATP-binding | Helicase | Hydrolase | mRNA processing | mRNA splicing | Nucleotide-binding | Nucleus | Repeat | Spliceosome		Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing
Ixodes ricinus	34613	A0A131XXE0	RuvB-like helicase		458	Unreviewed	Nucleus	chromatin organization | DNA recombination | DNA repair | positive regulation of gene expression | regulation of canonical Wnt signaling pathway | regulation of cell population proliferation	ATP binding | ATP hydrolysis activity | DNA helicase activity | transcription coregulator activity	histone acetyltransferase complex | nucleus	ATP-binding | Chromatin regulator | DNA damage | DNA recombination | DNA repair | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Transcription | Transcription regulation		Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair
Ixodes ricinus	34613	A0A131XXI4	Casein kinase II subunit alpha		430	Unreviewed		regulation of cell cycle	ATP binding | protein serine/threonine kinase activity	cytosol | nucleus | protein kinase CK2 complex	ATP-binding | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase		Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling
Ixodes ricinus	34613	A0A131XXJ0	Protein detached		3642	Unreviewed	Cell membrane, sarcolemma | Cytoplasm, cytoskeleton	establishment of cell polarity | maintenance of presynaptic active zone structure | muscle cell cellular homeostasis | neuromuscular synaptic transmission | regulation of neurotransmitter secretion | regulation of short-term neuronal synaptic plasticity	actin binding | WW domain binding | zinc ion binding	cytoplasm | cytoskeleton | dystrophin-associated glycoprotein complex | neuromuscular junction | sarcolemma	Actin-binding | Calcium | Cell membrane | Coiled coil | Cytoplasm | Cytoskeleton | Membrane | Metal-binding | Repeat | Zinc | Zinc-finger		
Ixodes ricinus	34613	A0A131XZ36	dTCF		622	Unreviewed	Nucleus	canonical Wnt signaling pathway | mesodermal cell fate determination | negative regulation of DNA-templated transcription | positive regulation of gene expression | regulation of stem cell proliferation | salivary gland morphogenesis | spiracle morphogenesis, open tracheal system	DNA-binding transcription factor activity, RNA polymerase II-specific | kinase binding | RNA polymerase II cis-regulatory region sequence-specific DNA binding | transcription corepressor binding	beta-catenin-TCF complex | chromatin	Activator | DNA-binding | Nucleus | Transcription | Transcription regulation | Wnt signaling pathway		Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes
Ixodes ricinus	34613	A0A131XZ35	Tyrosine-protein kinase		808	Unreviewed	Endomembrane system	cell development | morphogenesis of an epithelium | neuron differentiation | positive regulation of cellular component organization | regulation of developmental process	ATP binding | non-membrane spanning protein tyrosine kinase activity | transmembrane receptor protein tyrosine kinase activity	endomembrane system	ATP-binding | Coiled coil | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | SH2 domain | Transferase | Tyrosine-protein kinase		
Ixodes ricinus	34613	A0A131XZ34	Oxaloacetate tautomerase FAHD1, mitochondrial		216	Unreviewed		carboxylic acid metabolic process	acetylpyruvate hydrolase activity | acylpyruvate hydrolase activity | metal ion binding | oxaloacetate decarboxylase activity | oxaloacetate tautomerase activity	mitochondrion	Metal-binding		
Ixodes ricinus	34613	A0A131XZ28	Cyclin-dependent kinase 8		462	Unreviewed	Nucleus		ATP binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	nucleus	ATP-binding | Kinase | Nucleotide-binding | Nucleus | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A131XYY3	DNA polymerase eta		713	Unreviewed	Nucleus	DNA repair | error-prone translesion synthesis | response to UV	damaged DNA binding | DNA-directed DNA polymerase activity | zinc ion binding	nucleus | replication fork | site of double-strand break	DNA damage | DNA repair | Magnesium | Metal-binding | Nucleotidyltransferase | Nucleus | Transferase | Ubl conjugation | Zinc | Zinc-finger		
Ixodes ricinus	34613	A0A131XYX1	Cyclin-dependent kinase 12		1097	Unreviewed	Nucleus	positive regulation of transcription elongation by RNA polymerase II	ATP binding | cyclin binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	cyclin/CDK positive transcription elongation factor complex	ATP-binding | Kinase | Nucleotide-binding | Nucleus | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A131XYU6	Dynamin-like GTPase OPA1, mitochondrial		948	Unreviewed	Mitochondrion inner membrane | Mitochondrion intermembrane space	apoptotic process | endocytosis | intracellular distribution of mitochondria | mitochondrial fission | mitochondrial fusion | peroxisome fission	GTP binding | GTPase activity | lipid binding | microtubule binding	microtubule | mitochondrial inner membrane | mitochondrial intermembrane space	Apoptosis | Coiled coil | Disulfide bond | GTP-binding | Hydrolase | Lipid-binding | Membrane | Mitochondrion | Mitochondrion inner membrane | Nucleotide-binding | Transit peptide | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A131XYR4	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1		915	Unreviewed	Nucleus	7-methylguanosine mRNA capping | methylation | mRNA modification	methyltransferase cap1 activity | nucleic acid binding	cytoplasm | nucleus	Methyltransferase | mRNA capping | mRNA processing | Nucleus | S-adenosyl-L-methionine | Transferase		S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1)
Ixodes ricinus	34613	A0A131XYQ1	Folylpolyglutamate synthase		553	Unreviewed	Cytoplasm | Mitochondrion inner membrane | Mitochondrion matrix	one-carbon metabolic process	ATP binding | metal ion binding | tetrahydrofolylpolyglutamate synthase activity	cytosol | mitochondrial inner membrane | mitochondrial matrix	ATP-binding | Cytoplasm | Ligase | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Nucleotide-binding | One-carbon metabolism		Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis
Ixodes ricinus	34613	A0A131XYM6	DDB1- and CUL4-associated factor 1		1458	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Nucleus	chromatin organization | protein ubiquitination	ATP binding | protein serine/threonine kinase activity	centrosome | Cul4-RING E3 ubiquitin ligase complex | nucleus	Acetylation | ATP-binding | Chromatin regulator | Cytoplasm | Cytoskeleton | Host-virus interaction | Kinase | Nucleotide-binding | Nucleus | Phosphoprotein | Repeat | Serine/threonine-protein kinase | Transcription | Transcription regulation | Transferase | Ubl conjugation pathway | WD repeat		
Ixodes ricinus	34613	A0A131XYJ2	RuvB-like helicase		455	Unreviewed	Nucleus	chromatin organization | DNA repair | positive regulation of macromolecule biosynthetic process | regulation of canonical Wnt signaling pathway | regulation of cell population proliferation	ATP binding | ATP hydrolysis activity | DNA helicase activity | transcription coregulator activity	histone acetyltransferase complex | nucleus	ATP-binding | Chromatin regulator | DNA damage | DNA repair | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Transcription | Transcription regulation		Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair
Ixodes ricinus	34613	A0A131XYG5	Ubiquitin-conjugating enzyme E2 H		181	Unreviewed			ATP binding | ligase activity | ubiquitin conjugating enzyme activity		Acetylation | ATP-binding | Ligase | Nucleotide-binding | Transferase | Ubl conjugation | Ubl conjugation pathway		Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A
Ixodes ricinus	34613	A0A131XYF2	Mothers against decapentaplegic homolog		637	Unreviewed	Cytoplasm | Nucleus	anatomical structure morphogenesis | BMP signaling pathway | cell differentiation | dauer larval development | regulation of developmental process | regulation of multicellular organismal process | SMAD protein signal transduction	DNA-binding transcription factor activity, RNA polymerase II-specific | I-SMAD binding | metal ion binding | RNA polymerase II cis-regulatory region sequence-specific DNA binding	cytoplasm | heteromeric SMAD protein complex	Coiled coil | Cytoplasm | DNA-binding | Metal-binding | Nucleus | Receptor | Transcription | Transcription regulation | Zinc		
Ixodes ricinus	34613	A0A131XZ72	cysteine--tRNA ligase		536	Unreviewed		cysteinyl-tRNA aminoacylation	ATP binding | cysteine-tRNA ligase activity | metal ion binding	cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Metal-binding | Nucleotide-binding | Protein biosynthesis | Zinc		In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants
Ixodes ricinus	34613	A0A131XYF0	General transcription and DNA repair factor IIH helicase/translocase subunit XPB		782	Unreviewed	Nucleus	nucleotide-excision repair | transcription initiation at RNA polymerase II promoter	3'-5' DNA helicase activity | ATP binding | DNA binding | hydrolase activity	nucleotide-excision repair factor 3 complex | transcription factor TFIIH holo complex | transcription preinitiation complex	ATP-binding | DNA damage | DNA repair | DNA-binding | Helicase | Hydrolase | Isomerase | Nucleotide-binding | Nucleus		
Ixodes ricinus	34613	A0A131XYA3	Glucosylceramidase		419	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Signal | Sphingolipid metabolism		
Ixodes ricinus	34613	A0A131XY74	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase		582	Unreviewed	Golgi apparatus membrane	oligosaccharide biosynthetic process | protein N-linked glycosylation	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity | metal ion binding	Golgi membrane | Golgi stack	Disulfide bond | Glycoprotein | Glycosyltransferase | Golgi apparatus | Manganese | Membrane | Metal-binding | Signal | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A131XY10	Kinesin-like protein		689	Unreviewed	Cytoplasm, cytoskeleton	microtubule-based movement	ATP binding | microtubule binding | microtubule motor activity | protein-containing complex binding	centriole | cilium | cytosol | kinesin II complex | microtubule	ATP-binding | Coiled coil | Cytoplasm | Cytoskeleton | Microtubule | Motor protein | Nucleotide-binding		
Ixodes ricinus	34613	A0A131XXY8	Germinal-center associated nuclear protein		1222	Unreviewed	Chromosome | Cytoplasm | Nucleus, nuclear pore complex | Nucleus, nucleoplasm	immune system process | mRNA export from nucleus | protein transport	protein-lysine-acetyltransferase activity	chromosome | cytoplasm | nuclear pore | nucleoplasm | transcription export complex 2	Acetylation | Acyltransferase | Chromosome | Coiled coil | Cytoplasm | Immunity | Methylation | mRNA transport | Nuclear pore complex | Nucleus | Phosphoprotein | Protein transport | Transferase | Translocation | Transport		As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations
Ixodes ricinus	34613	A0A131XXU9	dual-specificity kinase		383	Unreviewed		actin cytoskeleton organization	ATP binding | metal ion binding | protein serine/threonine kinase activity | protein serine/threonine/tyrosine kinase activity | protein tyrosine kinase activity	cytoplasm | nucleus	ATP-binding | Kinase | Magnesium | Manganese | Metal-binding | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Transferase | Tyrosine-protein kinase		
Ixodes ricinus	34613	A0A131XXU4	Tyrosine-protein kinase receptor		1496	Unreviewed	Membrane	glucose homeostasis | positive regulation of MAPK cascade | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ATP binding | insulin receptor activity | insulin receptor substrate binding | metal ion binding	axon | insulin receptor complex	ATP-binding | Cleavage on pair of basic residues | Disulfide bond | Glycoprotein | Kinase | Manganese | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Receptor | Repeat | Signal | Transferase | Transmembrane | Transmembrane helix | Tyrosine-protein kinase		
Ixodes ricinus	34613	A0A131XXT9	m7GpppX diphosphatase		319	Unreviewed	Cytoplasm | Nucleus	deadenylation-dependent decapping of nuclear-transcribed mRNA | mRNA processing | RNA splicing	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity | RNA 7-methylguanosine cap binding	nucleus | P-body	Acetylation | Cytoplasm | Hydrolase | mRNA processing | mRNA splicing | Nucleus | Phosphoprotein		
Ixodes ricinus	34613	A0A131XXR1	cyclin-dependent kinase		303	Unreviewed		G1/S transition of mitotic cell cycle | regulation of G2/M transition of mitotic cell cycle | regulation of gene expression | signal transduction	ATP binding | cyclin binding | cyclin-dependent protein serine/threonine kinase activity	cyclin-dependent protein kinase holoenzyme complex | cytoplasm | nucleus	ATP-binding | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A131XXP9	Bifunctional glutamate/proline--tRNA ligase		1501	Unreviewed		glutamyl-tRNA aminoacylation | prolyl-tRNA aminoacylation	ATP binding | glutamate-tRNA ligase activity | metal ion binding | proline-tRNA ligase activity | RNA binding	aminoacyl-tRNA synthetase multienzyme complex | cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Metal-binding | Multifunctional enzyme | Nucleotide-binding | Phosphoprotein | Protein biosynthesis | RNA-binding | Zinc		
Ixodes ricinus	34613	A0A131XXM8	Protein transport protein Sec31A		1217	Unreviewed	Cytoplasmic vesicle membrane | Endoplasmic reticulum membrane	COPII-coated vesicle cargo loading | endoplasmic reticulum organization | protein transport	structural molecule activity	COPII vesicle coat | endoplasmic reticulum exit site | endoplasmic reticulum membrane	Cytoplasm | Cytoplasmic vesicle | Endoplasmic reticulum | ER-Golgi transport | Membrane | Protein transport | Repeat | Transport | WD repeat		Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules
Ixodes ricinus	34613	A0A131XXM5	Cyclin-dependent kinase 7		337	Unreviewed	Nucleus	cell division | positive regulation of transcription by RNA polymerase II	ATP binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	cytoplasm | transcription factor TFIIK complex	ATP-binding | Cell cycle | Cell division | Kinase | Nucleotide-binding | Nucleus | Phosphoprotein | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A131XXM0	3'(2'),5'-bisphosphate nucleotidase 1		316	Unreviewed		phosphatidylinositol phosphate biosynthetic process	3'(2'),5'-bisphosphate nucleotidase activity | inositol-1,4-bisphosphate 1-phosphatase activity | metal ion binding		Hydrolase | Lithium | Magnesium | Metal-binding		
Ixodes ricinus	34613	A0A131XXJ6	E3 ubiquitin-protein ligase CBL		459	Unreviewed	Cytoplasm	cell surface receptor signaling pathway | protein ubiquitination | regulation of signaling	calcium ion binding | kinase activity | phosphotyrosine residue binding | receptor tyrosine kinase binding | SH3 domain binding | ubiquitin protein ligase activity | zinc ion binding	cytoplasm | membrane raft | plasma membrane	Calcium | Cytoplasm | Kinase | Metal-binding | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome
Ixodes ricinus	34613	A0A131XYE1	Protein adenylyltransferase Fic		497	Unreviewed	Membrane		AMPylase activity | ATP binding	membrane	ATP-binding | Membrane | Nucleotide-binding | Nucleotidyltransferase | Repeat | TPR repeat | Transferase | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A0K8RB99	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial		477	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	4 iron, 4 sulfur cluster binding | FMN binding | metal ion binding | NAD binding | NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	4Fe-4S | Electron transport | Flavoprotein | FMN | Iron | Iron-sulfur | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Transit peptide | Translocase | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I
Ixodes ricinus	34613	A0A6B0VHZ6	Glutamate synthase [NADH]		2085	Unreviewed		ammonia assimilation cycle | L-glutamate biosynthetic process	3 iron, 4 sulfur cluster binding | flavin adenine dinucleotide binding | FMN binding | glutamate synthase (NADH) activity | glutamate synthase (NADPH) activity | iron ion binding | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor		3Fe-4S | Amino-acid biosynthesis | Coiled coil | FAD | Flavoprotein | FMN | Glutamate biosynthesis | Glutamine amidotransferase | Iron | Iron-sulfur | Metal-binding | Oxidoreductase		Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate
Ixodes ricinus	34613	A0A0K8RAW5	Inosine-5'-monophosphate dehydrogenase		514	Unreviewed	Cytoplasm	GMP biosynthetic process | GTP biosynthetic process	IMP dehydrogenase activity | metal ion binding | nucleotide binding	cytoplasm	CBS domain | Cytoplasm | GMP biosynthesis | Metal-binding | NAD | Oxidoreductase | Potassium | Purine biosynthesis		Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
Ixodes ricinus	34613	A0A131XXU1	Flavin-containing monooxygenase		542	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | hypotaurine monooxygenase activity | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Ixodes ricinus	34613	A0A131XVT5	Lysine-specific histone demethylase 1A		666	Unreviewed	Chromosome | Nucleus	DNA repair-dependent chromatin remodeling | methylation | negative regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | positive regulation of multicellular organismal process | positive regulation of neural precursor cell proliferation | positive regulation of transcription by RNA polymerase II | regulation of neurogenesis	chromatin binding | enzyme binding | FAD-dependent H3K4me/H3K4me3 demethylase activity | flavin adenine dinucleotide binding | histone H3K9 demethylase activity | methyltransferase activity | MRF binding | RNA binding | RNA polymerase II-specific DNA-binding transcription factor binding | transcription coactivator activity | transcription corepressor activity	chromatin | nucleus	Acetylation | Chromatin regulator | Chromosome | Coiled coil | Developmental protein | FAD | Flavoprotein | Isopeptide bond | Methyltransferase | Nucleus | Oxidoreductase | Phosphoprotein | Repressor | Transcription | Transcription regulation | Transferase | Ubl conjugation		
Ixodes ricinus	34613	A0A131XV10	Dual specificity mitogen-activated protein kinase kinase 7		400	Unreviewed	Cytoplasm | Nucleus	apoptotic process | positive regulation of autophagy | positive regulation of intracellular signal transduction | positive regulation of programmed cell death | regulation of MAPK cascade | response to stress	ATP binding | magnesium ion binding | MAP kinase kinase activity | protein serine/threonine kinase activity | protein tyrosine kinase activity	cytoplasm | nucleus	Acetylation | Apoptosis | ATP-binding | Coiled coil | Cytoplasm | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Nucleus | Phosphoprotein | Serine/threonine-protein kinase | Stress response | Transferase | Tyrosine-protein kinase		
Ixodes ricinus	34613	A0A0K8RS30	(3R)-3-hydroxyacyl-CoA dehydrogenase		289	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8RRF1	(3R)-3-hydroxyacyl-CoA dehydrogenase		296	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8RQS0	(3R)-3-hydroxyacyl-CoA dehydrogenase		341	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	A0A0K8RNJ1	3-hydroxyacyl-CoA dehydrogenase type-2		261	Unreviewed		androgen metabolic process | estrogen metabolic process | fatty acid metabolic process	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity | androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity | estradiol 17-beta-dehydrogenase [NAD(P)+] activity	mitochondrion	Oxidoreductase		
Ixodes ricinus	34613	A0A0K8RML3	(3R)-3-hydroxyacyl-CoA dehydrogenase		322	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8RMK9	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8RMF0	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8RKM2	(3R)-3-hydroxyacyl-CoA dehydrogenase		296	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8RGP2	(3R)-3-hydroxyacyl-CoA dehydrogenase		293	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8RG75	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8RDG3	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		119	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	A0A0K8RD42	Lysosomal dipeptide transporter MFSD1		386	Unreviewed	Lysosome membrane		transmembrane transporter activity	lysosomal membrane	Lysosome | Membrane | Sugar transport | Transmembrane | Transmembrane helix | Transport		Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis
Ixodes ricinus	34613	A0A0K8R8D7	(3R)-3-hydroxyacyl-CoA dehydrogenase		293	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8R8D4	(3R)-3-hydroxyacyl-CoA dehydrogenase		295	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8R7W2	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8R790	(3R)-3-hydroxyacyl-CoA dehydrogenase		293	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8R6S1	(3R)-3-hydroxyacyl-CoA dehydrogenase		316	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8R6P8	(3R)-3-hydroxyacyl-CoA dehydrogenase		295	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8R6E6	(3R)-3-hydroxyacyl-CoA dehydrogenase		293	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8R682	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8R5X6	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8R5F3	(3R)-3-hydroxyacyl-CoA dehydrogenase		342	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Membrane | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A0K8R2Y6	(3R)-3-hydroxyacyl-CoA dehydrogenase		297	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8R2R3	(3R)-3-hydroxyacyl-CoA dehydrogenase		297	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A131XYV6	1-acylglycerol-3-phosphate O-acyltransferase ABHD5		404	Unreviewed	Cytoplasm | Lipid droplet	cell differentiation | fatty acid metabolic process | lipid homeostasis | phosphatidic acid biosynthetic process	1-acylglycerol-3-phosphate O-acyltransferase activity | carboxylic ester hydrolase activity	lipid droplet | mitochondrion	Acyltransferase | Cytoplasm | Differentiation | Fatty acid metabolism | Hydrolase | Lipid biosynthesis | Lipid droplet | Lipid metabolism | Signal | Transferase		Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion
Ixodes ricinus	34613	A0A0K8R2R1	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A131XZC9	Glucosylceramidase		474	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Signal | Sphingolipid metabolism		
Ixodes ricinus	34613	A0A131Y0C3	Flavin-containing monooxygenase		540	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Ixodes ricinus	34613	A0A147BVG1	(3R)-3-hydroxyacyl-CoA dehydrogenase		316	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A147BVC8	(3R)-3-hydroxyacyl-CoA dehydrogenase		290	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A147BTM3	PRKCA-binding protein		414	Unreviewed	Cytoplasm, cytoskeleton | Cytoplasm, perinuclear region | Membrane | Postsynaptic density | Synapse, synaptosome	dendritic spine maintenance | intracellular protein transport | positive regulation of receptor internalization | receptor clustering | regulation of Arp2/3 complex-mediated actin nucleation	actin binding | metal ion binding | phospholipid binding | protein domain specific binding | protein kinase C binding	cytoskeleton | neuron projection | perinuclear region of cytoplasm | plasma membrane | postsynaptic density | postsynaptic early endosome | synaptic vesicle | trans-Golgi network membrane	Actin-binding | Calcium | Cytoplasm | Cytoskeleton | Lipoprotein | Membrane | Metal-binding | Palmitate | Phosphoprotein | Synapse | Synaptosome | Zinc		Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function
Ixodes ricinus	34613	A0A147BTF2	RNA-directed DNA polymerase		879	Unreviewed	Cytoplasm | Nucleus	DNA integration | DNA recombination | proteolysis | viral translational frameshifting	aspartic-type endopeptidase activity | ATP binding | DNA binding | DNA-directed DNA polymerase activity | RNA binding | RNA-directed DNA polymerase activity | RNA-DNA hybrid ribonuclease activity | zinc ion binding	cytoplasm | DNA polymerase complex | nucleus	Aspartyl protease | ATP-binding | Cytoplasm | DNA integration | DNA recombination | DNA-binding | DNA-directed DNA polymerase | Endonuclease | Hydrolase | Magnesium | Metal-binding | Multifunctional enzyme | Nuclease | Nucleotide-binding | Nucleotidyltransferase | Nucleus | Protease | Ribosomal frameshifting | RNA-binding | RNA-directed DNA polymerase | Transferase | Viral release from host cell | Virion maturation | Zinc | Zinc-finger		Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the genomic RNA-nucleocapsid complex
Ixodes ricinus	34613	A0A147BR19	RNA-directed DNA polymerase		861	Unreviewed	Cytoplasm | Nucleus	DNA integration | DNA recombination | proteolysis | viral translational frameshifting	aspartic-type endopeptidase activity | ATP binding | DNA binding | DNA-directed DNA polymerase activity | RNA binding | RNA-directed DNA polymerase activity | RNA-DNA hybrid ribonuclease activity | zinc ion binding	cytoplasm | DNA polymerase complex | nucleus	Aspartyl protease | ATP-binding | Cytoplasm | DNA integration | DNA recombination | DNA-binding | DNA-directed DNA polymerase | Endonuclease | Hydrolase | Magnesium | Metal-binding | Multifunctional enzyme | Nuclease | Nucleotide-binding | Nucleotidyltransferase | Nucleus | Protease | Ribosomal frameshifting | RNA-binding | RNA-directed DNA polymerase | Signal | Transferase | Viral release from host cell | Virion maturation | Zinc | Zinc-finger		Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the genomic RNA-nucleocapsid complex
Ixodes ricinus	34613	A0A147BQW3	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		249	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	A0A147BNT0	Putative cadherin egf lag seven-pass g-type receptor		2989	Unreviewed	Cell membrane	adherens junction organization | animal organ morphogenesis | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | cell migration | cell morphogenesis | cell-cell adhesion mediated by cadherin | cell-cell junction assembly | developmental growth | digestive tract development | establishment of planar polarity | establishment or maintenance of cell polarity | homophilic cell adhesion via plasma membrane adhesion molecules | intracellular protein localization | open tracheal system development | salivary gland development | tube morphogenesis	beta-catenin binding | cadherin binding | calcium ion binding	actin-based cell projection | adherens junction | catenin complex | dendrite	Calcium | Cell adhesion | Cell membrane | Disulfide bond | EGF-like domain | Glycoprotein | Membrane | Receptor | Repeat | Signal | Transmembrane | Transmembrane helix		Cadherins are calcium-dependent cell adhesion proteins
Ixodes ricinus	34613	A0A147BM44	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		248	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	A0A147BJS1	RNA-directed DNA polymerase		955	Unreviewed	Cytoplasm | Nucleus	DNA integration | DNA recombination | proteolysis | viral translational frameshifting	aspartic-type endopeptidase activity | ATP binding | DNA binding | DNA-directed DNA polymerase activity | RNA binding | RNA-directed DNA polymerase activity | RNA-DNA hybrid ribonuclease activity | zinc ion binding	cytoplasm | DNA polymerase complex | nucleus	Aspartyl protease | ATP-binding | Cytoplasm | DNA integration | DNA recombination | DNA-binding | DNA-directed DNA polymerase | Endonuclease | Hydrolase | Magnesium | Metal-binding | Multifunctional enzyme | Nuclease | Nucleotide-binding | Nucleotidyltransferase | Nucleus | Protease | Ribosomal frameshifting | RNA-binding | RNA-directed DNA polymerase | Transferase | Viral release from host cell | Virion maturation | Zinc | Zinc-finger		Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the genomic RNA-nucleocapsid complex
Ixodes ricinus	34613	A0A147BHR4	glycerophosphocholine cholinephosphodiesterase		488	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Ixodes ricinus	34613	A0A147BGQ1	Diacylglycerol lipase-alpha		789	Unreviewed	Cell projection, dendritic spine membrane | Early endosome membrane | Postsynaptic density membrane	arachidonate metabolic process | diacylglycerol catabolic process | retrograde trans-synaptic signaling by endocannabinoid	lipoprotein lipase activity | metal ion binding | monoacylglycerol lipase activity	dendritic spine membrane | early endosome membrane | postsynaptic density membrane	Calcium | Cell membrane | Cell projection | Endosome | Glycoprotein | Hydrolase | Lipid degradation | Lipid metabolism | Membrane | Metal-binding | Phosphoprotein | Postsynaptic cell membrane | Synapse | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A147BGN3	Cyclin-dependent kinase 4 inhibitor D		919	Unreviewed	Cytoplasm | Nucleus | Target cell membrane	attachment of spindle microtubules to kinetochore | exocytosis | intercellular bridge organization | male meiotic nuclear division | mitotic sister chromatid separation | mitotic spindle assembly checkpoint signaling | negative regulation of cell cycle G1/S phase transition	ATP binding | enzyme binding | protein kinase activity	cytoplasm | host cell presynaptic membrane | intercellular bridge | kinetochore | midbody | nucleus | other organism cell membrane	Acetylation | ANK repeat | Cell cycle | Cytoplasm | Exocytosis | Kinase | Membrane | Neurotoxin | Nucleus | Presynaptic neurotoxin | Repeat | Target cell membrane | Target membrane | Toxin | Transferase		Interacts strongly with CDK4 and CDK6 and inhibits them
Ixodes ricinus	34613	A0A147BGL2	Diacylglycerol lipase-alpha		1074	Unreviewed	Cell projection, dendritic spine membrane | Early endosome membrane | Postsynaptic density membrane	arachidonate metabolic process | diacylglycerol catabolic process | retrograde trans-synaptic signaling by endocannabinoid	lipoprotein lipase activity | metal ion binding | monoacylglycerol lipase activity	dendritic spine membrane | early endosome membrane | postsynaptic density membrane	Calcium | Cell membrane | Cell projection | Endosome | Glycoprotein | Hydrolase | Lipid degradation | Lipid metabolism | Membrane | Metal-binding | Phosphoprotein | Postsynaptic cell membrane | Synapse | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A147BGF9	Flavin-containing monooxygenase		546	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | hypotaurine monooxygenase activity | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Ixodes ricinus	34613	A0A131YBL3	Poly [ADP-ribose] polymerase		936	Unreviewed	Chromosome | Cytoplasm, cytosol | Nucleus, nucleolus	double-strand break repair | innate immune response | protein poly-ADP-ribosylation	DNA binding | NAD+ poly-ADP-ribosyltransferase activity | NAD+-protein-aspartate ADP-ribosyltransferase activity | NAD+-protein-glutamate ADP-ribosyltransferase activity | NAD+-protein-histidine ADP-ribosyltransferase activity | NAD+-protein-serine ADP-ribosyltransferase activity | NAD+-protein-tyrosine ADP-ribosyltransferase activity | nucleotidyltransferase activity | zinc ion binding	chromosome | cytosol | nucleolus	ADP-ribosylation | Allosteric enzyme | Chromosome | Cytoplasm | DNA-binding | Glycosyltransferase | Immunity | Innate immunity | Isopeptide bond | Metal-binding | NAD | Nucleotidyltransferase | Nucleus | Repeat | Transcription | Transcription regulation | Transferase | Zinc | Zinc-finger		
Ixodes ricinus	34613	A0A131Y3M1	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		256	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	A0A131Y3I7	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		254	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	A0A131Y368	Glutamate synthase [NADH]		2048	Unreviewed		ammonia assimilation cycle | L-glutamate biosynthetic process	3 iron, 4 sulfur cluster binding | flavin adenine dinucleotide binding | FMN binding | glutamate synthase (NADH) activity | glutamate synthase (NADPH) activity | iron ion binding | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor		3Fe-4S | Amino-acid biosynthesis | Coiled coil | FAD | Flavoprotein | FMN | Glutamate biosynthesis | Glutamine amidotransferase | Iron | Iron-sulfur | Metal-binding | Oxidoreductase		Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate
Ixodes ricinus	34613	A0A131Y336	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		259	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	A0A131Y2X8	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		259	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	A0A131Y2M0	Lysosomal dipeptide transporter MFSD1		552	Unreviewed	Lysosome membrane		transmembrane transporter activity	lysosomal membrane	Lysosome | Membrane | Signal | Sugar transport | Transmembrane | Transmembrane helix | Transport		Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis
Ixodes ricinus	34613	A0A131Y1W7	Flavin-containing monooxygenase		546	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Ixodes ricinus	34613	A0A131Y1Q4	Acylglycerol kinase, mitochondrial		452	Unreviewed	Mitochondrion inner membrane | Mitochondrion intermembrane space	ceramide biosynthetic process | glycerolipid metabolic process | sphingosine biosynthetic process	acylglycerol kinase activity | ATP binding | ATP-dependent diacylglycerol kinase activity | ceramide kinase activity	mitochondrial inner membrane | mitochondrial intermembrane space	ATP-binding | Kinase | Lipid metabolism | Membrane | Mitochondrion | Mitochondrion inner membrane | Nucleotide-binding | Transferase		
Ixodes ricinus	34613	A0A131Y1P5	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		248	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	A0A131Y1G7	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		259	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	A0A131Y133	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		158	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	A0A131Y0S6	PAN2-PAN3 deadenylation complex subunit PAN3	PAN3	764	Unreviewed	Cytoplasm, P-body	mRNA processing | nuclear-transcribed mRNA poly(A) tail shortening | positive regulation of cytoplasmic mRNA processing body assembly	ATP binding | poly(A) binding | protein kinase activity | zinc ion binding	P-body | PAN complex	ATP-binding | Coiled coil | Cytoplasm | Metal-binding | mRNA processing | Nucleotide-binding | Zinc | Zinc-finger		Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins
Ixodes ricinus	34613	A0A131Y0A0	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		259	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	A0A090XDV6	Katanin p60 ATPase-containing subunit A1	KATNA1	527	Unreviewed	Cytoplasm, cytoskeleton, spindle | Cytoplasm | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Cytoplasm, cytoskeleton, spindle pole	cell division | microtubule severing	ATP binding | ATP hydrolysis activity | microtubule binding | microtubule severing ATPase activity	centrosome | cytoplasm | microtubule | spindle pole	ATP-binding | Cell cycle | Cell division | Cytoplasm | Cytoskeleton | Isomerase | Microtubule | Mitosis | Nucleotide-binding		Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation
Ixodes ricinus	34613	A0A090X8Y0	Diacylglycerol lipase-alpha		573	Unreviewed	Cell projection, dendritic spine membrane | Early endosome membrane | Postsynaptic density membrane	arachidonate metabolic process | diacylglycerol catabolic process | retrograde trans-synaptic signaling by endocannabinoid	lipoprotein lipase activity | metal ion binding | monoacylglycerol lipase activity	dendritic spine membrane | early endosome membrane | postsynaptic density membrane	Calcium | Cell membrane | Cell projection | Endosome | Glycoprotein | Hydrolase | Lipid degradation | Lipid metabolism | Membrane | Metal-binding | Phosphoprotein | Postsynaptic cell membrane | Synapse | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A090X8K6	glycerophosphocholine cholinephosphodiesterase		350	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Ixodes ricinus	34613	A0A0K8RJ67	Evasin P1127		108	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5 and CXCL8
Ixodes ricinus	34613	A0A0K8RDJ1	Evasin P1162		99	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5 and CXCL8
Ixodes ricinus	34613	A0A0K8R7D4	Evasin P458		90	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6 and CXCL13
Ixodes ricinus	34613	A0A090XE98	Evasin P1077		91	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6 and CXCL11
Ixodes ricinus	34613	A0A090XBL6	Evasin P1080		118	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL10, CXCL11 and CXCL13
Ixodes ricinus	34613	A0A090XBH9	Evasin P1090		83	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL10, CXCL11 and CXCL13
Ixodes ricinus	34613	V5HBW0	Evasin P1156		108	Reviewed	Secreted	negative regulation of chemokine activity	chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which has chemokine-neutralizing activity and binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6 and CXCL8
Ixodes ricinus	34613	V5H924	Mialostatin		140	Reviewed	Secreted		cysteine-type endopeptidase inhibitor activity	cytoplasm | extracellular space | vesicle	3D-structure | Disulfide bond | Protease inhibitor | Secreted | Signal | Thiol protease inhibitor	6ZTK	Inhibitor of cysteine proteinases (PubMed:34065290, PubMed:38444844). Inhibits several endogenous midgut digestive cysteine proteases, such as cathepsin L1, L3, B and C, but not aspartic protease cathepsin D1 and cysteine protease legumain (PubMed:34065290). Inhibits proteolysis of blood proteins catalyzed by tick gut cysteine cathepsins (PubMed:34065290). Inhibits host cathepsin B (CSTB), C (CTSC), H (CTSH), K (CTSK), L (CTSL) and S (CTSS) (PubMed:34065290, PubMed:38444844)
Ixodes ricinus	34613	P85043	Periviscerokinin		9	Reviewed	Secreted	neuropeptide signaling pathway | regulation of smooth muscle contraction		extracellular region	Amidation | Direct protein sequencing | Neuropeptide | Secreted		Mediates visceral muscle contractile activity (myotropic activity)
Ixodes ricinus	34613	P84252	Cuticle protein 16.8		161	Reviewed			chitin binding | structural constituent of chitin-based larval cuticle	chitin-based extracellular matrix	Chitin-binding | Cuticle | Direct protein sequencing | Pyrrolidone carboxylic acid		Component of the cuticle of the tick. Binds chitin
Ixodes ricinus	34613	P84251	Cuticle protein 10.9		102	Reviewed			chitin binding | structural constituent of chitin-based larval cuticle	chitin-based extracellular matrix	Chitin-binding | Cuticle | Direct protein sequencing | Pyrrolidone carboxylic acid		Component of the cuticle of the tick. Binds chitin
Ixodes ricinus	34613	A8CZZ1	Salivary protein 15 Iric-2		136	Reviewed	Secreted			extracellular region	Glycoprotein | Secreted | Signal		Salivary tick protein that downregulates host immune system by binding to both dendritic cells, and CD4(+) T cells. Specifically binds to the CD4 coreceptor on T cells. This interaction prevents the activation of the Src kinase, Lck, and its downstream substrate Zap-70, and results in deficient activation of PLCgamma1, the repression of calcium fluxes triggered by T-cell antigen receptor (TCR) ligation, and a subsequent reduction in interleukin-2 production. This salivary protein also binds to DC-SIGN (CD209) on dendritic cells (DC) and activates the Raf-1 kinase/MEK signaling pathway that results in down-regulating expression of pro-inflammatory cytokines. Furthermore, it inhibits T cell proliferation induced by DCs (By similarity). In addition, it inhibits in vitro keratinocyte inflammation induced by Borrelia burgdorferi or by the major outer surface protein (OspC) of Borrelia (By similarity). In addition, it downregulates chemokines and monocyte chemoattractant protein 1, as well as several antimicrobial peptides such as defensins, cathelicidin, psoriasin, and RNase 7 (By similarity). Apart from its immunomodulatory activities, it is also associated with protection of Borrelia spirochetes from antibody-mediated killing through its binding to OspC (By similarity) (PubMed:33401196). In vivo, tests on different immune disease animal models show promising therapeutic results, e.g., in inhibiting HIV infection, experimental autoimmune encephalomyelitis, transplantation rejection, and asthma (By similarity)
Ixodes ricinus	34613	Q9GP15	Kunitz-type anticoagulant protein Ir-CPI	CPI	86	Reviewed	Secreted		serine-type endopeptidase inhibitor activity | toxin activity	extracellular space	Blood coagulation cascade inhibiting toxin | Disulfide bond | Glycoprotein | Hemostasis impairing toxin | Protease inhibitor | Secreted | Serine protease inhibitor | Signal | Toxin		Anticoagulant protein (PubMed:19808248). Increases fibrinolysis time (PubMed:19808248). Inhibits thrombin generation (PubMed:19808248). Inhibits the generation of the active forms of host coagulation factor XII, factor XI and plasma kallikrein (PubMed:19808248)
Ixodes ricinus	34613	Q9GP13	Iris		377	Reviewed	Secreted	immune system process	serine-type endopeptidase inhibitor activity | toxin activity	extracellular space	Blood coagulation cascade inhibiting toxin | Glycoprotein | Hemostasis impairing toxin | Immunity | Platelet aggregation inhibiting toxin | Protease inhibitor | Secreted | Serine protease inhibitor | Toxin		Serine protease inhibitor with anticoagulant and immunosuppressive properties that can modulate blood feeding of ticks on vertebrate species (PubMed:11792703, PubMed:16672226, PubMed:19438720). Strongly inhibits human leukocyte elastase (ELANE) and porcine pancreatic elastase. Moderately inhibits human tPA/tissue-type plasminogen activator (PLAT), coagulation factor Xa (F10), thrombin (F2) and trypsin (PubMed:16672226). Does not inhibit human plasmin (PLG) (PubMed:16672226). Inhibits platelet aggregation (PubMed:16672226). Inhibits the intrinsic pathway of blood coagulation in the host (PubMed:16672226). Inhibits fibrinolysis in the host (PubMed:16672226). Inhibits proliferation of mouse splenocytes (PubMed:11792703). Decreases the number of IFN-gamma (IFNG)-producing human peripheral blood mononuclear cells (PBMCs) after stimulation with phytohemagglutinin A (PHA) (PubMed:11792703). Increases the number of IL10-producing human PBMCs after stimulation with lipopolysaccharides (LPS) with no significant effect on IL10 production (PubMed:11792703). Inhibits production of IFNG, IL6, TNF (TNF) and CXCL8 by human PBMCs (PubMed:11792703, PubMed:19438720). Binds to monocyte/macrophage subpopulation of the host PBMCs (PubMed:19438720). Increases both survival rate and survival time in mice with LPS-induced endotoxemic shock (PubMed:19438720)
Ixodes ricinus	34613	Q7YXK5	Defensin-1	Def1	76	Reviewed	Secreted	defense response to Gram-positive bacterium | hemolysis in another organism		extracellular region	Antibiotic | Antimicrobial | Cleavage on pair of basic residues | Cytolysis | Defensin | Disulfide bond | Hemolysis | Secreted | Signal		Antibacterial activity against Gram-positive bacteria but not Gram-negative bacteria (PubMed:21504572). Also shows hemolytic activity on human erythrocytes (PubMed:21504572)
Ixodes ricinus	34613	A8CZZ8	Salivary protein 15 Iric-3		124	Reviewed	Secreted			extracellular region	Glycoprotein | Secreted | Signal		Salivary tick protein that downregulates host immune system by binding to both dendritic cells, and CD4(+) T cells. Specifically binds to the CD4 coreceptor on T cells. This interaction prevents the activation of the Src kinase, Lck, and its downstream substrate Zap-70, and results in deficient activation of PLCgamma1, the repression of calcium fluxes triggered by T-cell antigen receptor (TCR) ligation, and a subsequent reduction in interleukin-2 production. This salivary protein also binds to DC-SIGN (CD209) on dendritic cells (DC) and activates the Raf-1 kinase/MEK signaling pathway that results in down-regulating expression of pro-inflammatory cytokines. Furthermore, it inhibits T cell proliferation induced by DCs (By similarity). In addition, it inhibits in vitro keratinocyte inflammation induced by Borrelia burgdorferi or by the major outer surface protein (OspC) of Borrelia (By similarity). In addition, it downregulates chemokines and monocyte chemoattractant protein 1, as well as several antimicrobial peptides such as defensins, cathelicidin, psoriasin, and RNase 7 (By similarity). Apart from its immunomodulatory activities, it is also associated with protection of Borrelia spirochetes from antibody-mediated killing through its binding to OspC (By similarity) (PubMed:33401196). In vivo, tests on different immune disease animal models show promising therapeutic results, e.g., in inhibiting HIV infection, experimental autoimmune encephalomyelitis, transplantation rejection, and asthma (By similarity)
Ixodes ricinus	34613	A0A0K8RJ89	Iripin-5		393	Reviewed	Secreted	immune system process	serine-type endopeptidase inhibitor activity | toxin activity	extracellular space	3D-structure | Complement system impairing toxin | Glycoprotein | Immunity | Protease inhibitor | Secreted | Serine protease inhibitor | Signal | Toxin	7B2T	Serine protease inhibitor that modulates blood feeding of ticks on vertebrate species (PubMed:34473088). Inhibits host neutrophil elastase (ELANE) and proteinase 3/myeloblastin (PRTN3) (PubMed:34473088). Moderately inhibits host chymase, cathepsin G (CTSG), trypsin and alpha-chymotrypsin (PubMed:34473088). Decreases host neutrophil migration (PubMed:34473088). Decreases nitric oxide production by host macrophages (PubMed:34473088). Decreases host complement activity (PubMed:34473088)
Ixodes ricinus	34613	Q06B75	Iripin-1		392	Reviewed	Secreted	immune system process	serine-type endopeptidase inhibitor activity	extracellular space	3D-structure | Glycoprotein | Immunity | Protease inhibitor | Secreted | Serine protease inhibitor | Signal	7QTZ	Serine protease inhibitor that modulates blood feeding of ticks on vertebrate species (PubMed:36756125). Modestly inhibits human trypsin, plasma kallikrein (KLKB1), matriptase (ST14) and plasmin (PLG) via a classic serpin inhibitory mechanism (PubMed:36756125). Modestly reduces enzymatic activity of human alpha-chymotrypsin, coagulation factor Xa (F10), factor XIIa (F12), cathepsin G (CTSG), tPA/tissue-type plasminogen activator (PLAT) and uPA/urokinase-type plasminogen activator (PLAU) (PubMed:36756125). Probably acts as a substrate rather than an inhibitor for the human neutrophil elastase (ELANE) and thus reduces its enzymatic activity in in vitro assays (PubMed:36756125). Decreases expression of adhesion molecules VCAM1 and CD99 on the surface of human cells (PubMed:36756125). Increases the production of chemokines for neutrophils and monocytes, such as KC/CXCL1, MIP-2/CXCL2 and MIP-1/CCL2, and anti-inflammatory cytokine IL10 in mouse inflammation models (PubMed:36756125). Reduces the recruitment of mouse neutrophils and monocytes to the site of inflammation (PubMed:36756125). Decreases expression of CXCR2 on the surface of mouse neutrophils (PubMed:36756125). Increases expression of integrin ITGAM/ITGB2 on the surface of mouse neutrophils (PubMed:36756125)
Ixodes ricinus	34613	A0A0K8RJV9	Iripin-4		392	Reviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	3D-structure | Glycoprotein | Protease inhibitor | Secreted | Serine protease inhibitor | Signal	7ZAS | 7ZBF	Serpin with unknown function (PubMed:37092969). Weakly inhibits human granzyme B (GZMB) (PubMed:37092969). Acts as a substrate for porcine elastase (PubMed:37092969)
Ixodes ricinus	34613	A1EA99	Mite group 2 allergen-like Ixo r 2		144	Reviewed	Secreted	sterol transport	sterol binding	extracellular space	Disulfide bond | Secreted | Signal		Binds human IgE in vitro, and may neutralize IgE antibodies present in blood from repeatedly tick-bitten people. Does not have antimicrobial activity against E.coli or M.luteus
Ixodes ricinus	34613	A0A3S6I186	Iristatin		138	Reviewed	Secreted		cysteine-type endopeptidase inhibitor activity	cytoplasm | extracellular space | vesicle	3D-structure | Disulfide bond | Glycoprotein | Protease inhibitor | Secreted | Signal | Thiol protease inhibitor	5O46	Inhibitor of cysteine proteinases (PubMed:30747251, PubMed:38444844). Inhibits host cathepsin C (CTSC) and L (CTSL) (PubMed:30747251, PubMed:38444844). Suppresses IL2, IL4, IL9 and IFN-gamma (IFNG) production by different host T-cell populations (PubMed:30747251). Reduces IL6 and IL9 production by host mast cells (PubMed:30747251). Decreases nitric oxide (NO) production by host macrophages (PubMed:30747251). Decreases dendritic cell-dependent antigen-induced proliferation of host CD4 T-cell (PubMed:30747251). Impairs host leukocyte recruitment in vitro and in vivo (PubMed:30747251). Probably decreases apoptosis in host cells (PubMed:39821815)
Ixodes ricinus	34613	Q2HYY9	Defensin-2	Def2	74	Reviewed	Secreted	defense response to Gram-positive bacterium | hemolysis in another organism | sensory perception of itch	receptor ligand activity	extracellular region	Antibiotic | Antimicrobial | Cleavage on pair of basic residues | Defensin | Disulfide bond | Secreted | Signal		Antibacterial activity against Gram-positive bacteria but not Gram-negative bacteria (PubMed:21504572). Also shows hemolytic activity on human erythrocytes (PubMed:21504572). Elicits itch and scratching in human and mouse by activating the G-protein coupled receptor MRGPRX1 in sensory neurons of dorsal root ganglion, leading to sensitize TRPV1 in pruriceptors (PubMed:33358893)
Ixodes ricinus	34613	W6HZ31	Kunitz-type serine protease inhibitor IrSPI	SPI	94	Reviewed	Secreted	immune system process	serine-type endopeptidase inhibitor activity	extracellular region	Disulfide bond | Glycoprotein | Immunity | Protease inhibitor | Secreted | Serine protease inhibitor | Signal		Serine protease inhibitor that modulates blood feeding of ticks on vertebrate species (PubMed:25057911, PubMed:31614804). Moderately inhibits porcine elastase (PubMed:31614804). Slightly inhibits bovine chymotrypsin (PubMed:31614804). Represses proliferation of murine CD4+ T-lymphocytes in response to mitogenic stimulus (PubMed:31614804). Reduces secretion of several murine pro-inflammatory cytokines, such as CXCL10, CCL7, CCL4, CCL5, IL1B, IL13, IL18, IL6, IL9, IL5, TNF, IFNG, CCL11 and CSF2 (PubMed:31614804). Up-regulates murine IL2 secretion (PubMed:31614804). Does not inhibit bovine trypsin, human thrombin and porcine kallikrein (PubMed:31614804). Does not affect human blood coagulation, fibrinolysis, endothelial cell angiogenesis or apoptosis (PubMed:31614804)
Ixodes ricinus	34613	A0A0K8RCY5	Iripin-3		393	Reviewed	Secreted	immune system process	serine-type endopeptidase inhibitor activity | toxin activity	extracellular space	3D-structure | Blood coagulation cascade inhibiting toxin | Glycoprotein | Hemostasis impairing toxin | Immunity | Protease inhibitor | Secreted | Serine protease inhibitor | Signal | Toxin	7AHP	Serine protease inhibitor that modulates blood feeding of ticks on vertebrate species (PubMed:33732248). Moderately inhibits host plasma kallikrein (KLKB1), matriptase (ST14), trypsin, plasmin (PLG), thrombin (F2) and coagulation factor VIIa (F7) (PubMed:33732248). Slightly inhibits host alpha-chymotrypsin, tPA/tissue-type plasminogen activator (PLAT), uPA/urokinase-type plasminogen activator (PLAU) and coagulation factor XIIa (F12) (PubMed:33732248). Slightly inhibits the extrinsic pathway while not affecting the intrinsic and common pathways of host blood coagulation (PubMed:33732248). Decreases synthesis and secretion of IL6 by mouse bone marrow-derived macrophages (PubMed:33732248). Decreases viability of mouse B- and T-cells (PubMed:33732248). Decreases proliferation of mouse CD4+ T-cells in response to stimulation (PubMed:33732248). Inhibits Th1 immune responses in mouse cells (PubMed:33732248). Promotes differentiation of mouse regulatory T-cells (PubMed:33732248)
Ixodes ricinus	34613	Q06B74	Iripin-2		397	Reviewed	Secreted	immune system process	serine-type endopeptidase inhibitor activity | toxin activity	extracellular space	3D-structure | Glycoprotein | Hemostasis impairing toxin | Immunity | Platelet aggregation inhibiting toxin | Protease inhibitor | Secreted | Serine protease inhibitor | Signal | Toxin	3NDA	Serine protease inhibitor that modulates blood feeding of ticks on vertebrate species (PubMed:20940421). Inhibits host trypsin, thrombin (F2), alpha-chymotrypsin, cathepsin G (CTSG) and mast cell chymase (CMA1) (PubMed:20940421). Inhibits host cathepsin G- and thrombin-induced platelet aggregation (PubMed:20940421). Inhibits acute inflammation in the host (PubMed:20940421). Suppresses neutrophil recruitment in inflamed area (PubMed:20940421). Does not inhibit host plasmin (PLG), factor Xa (F10), factor XIa (F11), elastase and proteinase 3/myeloblastin (PRTN3) (PubMed:20940421)
Ixodes ricinus	34613	Q06B72	Iripin-8		402	Reviewed	Secreted	immune system process	serine-type endopeptidase inhibitor activity | toxin activity	extracellular space	3D-structure | Blood coagulation cascade inhibiting toxin | Complement system impairing toxin | Glycoprotein | Hemostasis impairing toxin | Immunity | Protease inhibitor | Secreted | Serine protease inhibitor | Signal | Toxin	7PMU	Serine protease inhibitor that modulates blood feeding of ticks on vertebrate species (PubMed:34502392). Inhibits the intrinsic and common pathways of blood coagulation in the host (PubMed:34502392). Inhibits host thrombin, factor VIIa, factor Xa, factor XIa, factor XIIa, plasmin and activated protein C (PubMed:34502392). Inhibits host trypsin and kallikrein (PubMed:34502392). Reduces host complement activity (PubMed:34502392). Does not affect proliferation of CD4+ T-cells and neutrophil migration (PubMed:34502392)
Ixodes ricinus	34613	A8CZZ0	Salivary protein 15 Iric-1		134	Reviewed	Secreted			extracellular region	Glycoprotein | Secreted | Signal		Salivary tick protein that downregulates host immune system by binding to both dendritic cells, and CD4(+) T cells. Specifically binds to the CD4 coreceptor on T cells. This interaction prevents the activation of the Src kinase, Lck, and its downstream substrate Zap-70, and results in deficient activation of PLCgamma1, the repression of calcium fluxes triggered by T-cell antigen receptor (TCR) ligation, and a subsequent reduction in interleukin-2 production. This salivary protein also binds to DC-SIGN (CD209) on dendritic cells (DC) and activates the Raf-1 kinase/MEK signaling pathway that results in down-regulating expression of pro-inflammatory cytokines. Furthermore, it inhibits T cell proliferation induced by DCs (By similarity). In addition, it inhibits in vitro keratinocyte inflammation induced by Borrelia burgdorferi or by the major outer surface protein (OspC) of Borrelia (PubMed:21134970). In addition, it downregulates chemokines and monocyte chemoattractant protein 1, as well as several antimicrobial peptides such as defensins, cathelicidin, psoriasin, and RNase 7 (PubMed:21134970). Apart from its immunomodulatory activities, it is also associated with protection of Borrelia spirochetes from antibody-mediated killing through its binding to OspC (PubMed:18752445, PubMed:33401196). In vivo, tests on different immune disease animal models show promising therapeutic results, e.g., in inhibiting HIV infection, experimental autoimmune encephalomyelitis, transplantation rejection, and asthma (By similarity)
Ixodes ricinus	34613	A0A0K8RAI0	Evasin P1134		135	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokine CXCL1
Ixodes ricinus	34613	V5GZ08	Evasin P1132		106	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL5 and CXCL8
Ixodes ricinus	34613	V5I3C5	Evasin P1174		104	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1 and CXCL8
Ixodes ricinus	34613	A0A0K8R374	Evasin P675		92	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL10, CXCL11 and CXCL13
Ixodes ricinus	34613	V5IID7	Putative m20 peptidase		509	Unreviewed		adaptive thermogenesis | amide biosynthetic process | amide catabolic process | amino acid metabolic process | lipid metabolic process | proteolysis	aminoacylase activity | metal ion binding | peptidase activity	extracellular region	Hydrolase | Metal-binding | Protease | Zinc		Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles
Ixodes ricinus	34613	V5HE67	Fatty acid synthase		2515	Unreviewed		fatty acid biosynthetic process	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity | 3-oxoacyl-[acyl-carrier-protein] synthase activity | [acyl-carrier-protein] S-acetyltransferase activity | enoyl-[acyl-carrier-protein] reductase (NADPH) activity | fatty acid synthase activity | fatty acyl-[ACP] hydrolase activity | phosphopantetheine binding		Acetylation | Fatty acid biosynthesis | Fatty acid metabolism | Hydrolase | Lipid biosynthesis | Lipid metabolism | Multifunctional enzyme | NAD | NADP | Oxidoreductase | Phosphopantetheine | Phosphoprotein | Pyridoxal phosphate | S-nitrosylation | Transferase		Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain
Ixodes ricinus	34613	V5H879	Alanine--glyoxylate aminotransferase 2, mitochondrial		371	Unreviewed	Mitochondrion	glyoxylate catabolic process | L-alanine catabolic process, by transamination	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity | alanine-glyoxylate transaminase activity | beta-alanine:pyruvate transaminase activity | pyridoxal phosphate binding	mitochondrion	Aminotransferase | Mitochondrion | Pyridoxal phosphate | Transferase | Transit peptide		Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure
Ixodes ricinus	34613	V5H6F2	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D		444	Unreviewed	Early endosome membrane | Endosome membrane | Golgi apparatus membrane | Nucleus envelope | Nucleus, nucleoplasm	N-acylethanolamine metabolic process | N-acylphosphatidylethanolamine metabolic process | phospholipid catabolic process | RNA 3'-end processing	metal ion binding | N-acylphosphatidylethanolamine-specific phospholipase D activity	early endosome membrane | Golgi membrane | nuclear envelope | nucleoplasm	Acetylation | Endosome | Golgi apparatus | Hydrolase | Lipid degradation | Lipid metabolism | Membrane | Metal-binding | Nucleus | Phospholipid degradation | Phospholipid metabolism | Zinc		D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs
Ixodes ricinus	34613	V5GZ70	Putative m20 peptidase		509	Unreviewed		adaptive thermogenesis | amide biosynthetic process | amide catabolic process | amino acid metabolic process | lipid metabolic process | proteolysis	aminoacylase activity | metal ion binding | peptidase activity	extracellular region	Hydrolase | Metal-binding | Protease | Zinc		Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles
Ixodes ricinus	34613	V5GUJ9	Alanine--glyoxylate aminotransferase 2, mitochondrial		463	Unreviewed	Mitochondrion	glyoxylate catabolic process | L-alanine catabolic process, by transamination	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity | alanine-glyoxylate transaminase activity | beta-alanine:pyruvate transaminase activity | pyridoxal phosphate binding	mitochondrion	Aminotransferase | Mitochondrion | Pyridoxal phosphate | Transferase | Transit peptide		Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure
Ixodes ricinus	34613	A0A6B0VET6	Hormone-sensitive lipase		790	Unreviewed	Cell membrane | Cytoplasm, cytosol | Lipid droplet | Membrane, caveola	cholesterol metabolic process | triglyceride catabolic process	monoacylglycerol lipase activity | sterol ester esterase activity | triacylglycerol lipase activity	caveola | cytosol | lipid droplet	Cell membrane | Cholesterol metabolism | Cytoplasm | Hydrolase | Lipid degradation | Lipid droplet | Lipid metabolism | Membrane | Phosphoprotein | Steroid metabolism | Sterol metabolism		
Ixodes ricinus	34613	A0A6B0VC97	Diacylglycerol O-acyltransferase 1		520	Unreviewed	Endoplasmic reticulum membrane	triglyceride biosynthetic process	diacylglycerol O-acyltransferase activity | retinol O-fatty-acyltransferase activity	endoplasmic reticulum membrane	Acyltransferase | Endoplasmic reticulum | Membrane | Transferase | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A147BWM8	Flavin-containing monooxygenase 1		484	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Ixodes ricinus	34613	A0A147BNI3	Neurogenic locus Notch protein		2390	Unreviewed	Cell membrane | Late endosome | Nucleus | Secreted | Target cell membrane	anterior/posterior pattern specification | axon guidance | cell fate specification | embryonic organ development | exocytosis | formation of animal organ boundary | gland development | hemopoiesis | larval development | negative regulation of multicellular organismal process | nervous system process | Notch signaling pathway | ommatidial rotation | positive regulation of neurogenesis | R3/R4 cell differentiation | regulation of cell-cell adhesion | regulation of transcription by RNA polymerase II | reproductive structure development | segmentation | sex differentiation | stem cell differentiation	calcium ion binding | protein domain specific binding	cell surface | extracellular region | host cell presynaptic membrane | late endosome | other organism cell membrane | plasma membrane | receptor complex | RNA polymerase II transcription regulator complex	Activator | ANK repeat | Calcium | Cell membrane | Developmental protein | Differentiation | Disulfide bond | EGF-like domain | Endosome | Exocytosis | Glycoprotein | Membrane | Metal-binding | Neurotoxin | Notch signaling pathway | Nucleus | Presynaptic neurotoxin | Receptor | Repeat | Secreted | Signal | Target cell membrane | Target membrane | Toxin | Transcription | Transcription regulation | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A131XZR0	ATP-binding cassette sub-family B member 6		762	Unreviewed	Cell membrane | Early endosome membrane | Endoplasmic reticulum membrane | Endosome membrane | Endosome, multivesicular body membrane | Golgi apparatus membrane | Late endosome membrane | Lysosome membrane | Melanosome membrane | Mitochondrion outer membrane | Secreted, extracellular exosome		ABC-type heme transporter activity | ATP binding | ATP hydrolysis activity | heme binding	early endosome membrane | endoplasmic reticulum membrane | extracellular region | Golgi membrane | lysosomal membrane | mitochondrial outer membrane | multivesicular body membrane | plasma membrane	ATP-binding | Cell membrane | Disulfide bond | Endoplasmic reticulum | Endosome | Golgi apparatus | Lysosome | Membrane | Mitochondrion | Mitochondrion outer membrane | Nucleotide-binding | Secreted | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		
Ixodes ricinus	34613	A0A131XYN6	Alanine--glyoxylate aminotransferase 2, mitochondrial		470	Unreviewed	Mitochondrion	glyoxylate catabolic process | L-alanine catabolic process, by transamination	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity | alanine-glyoxylate transaminase activity | beta-alanine:pyruvate transaminase activity | pyridoxal phosphate binding	mitochondrion	Aminotransferase | Mitochondrion | Pyridoxal phosphate | Transferase | Transit peptide		Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure
Ixodes ricinus	34613	A0A0K8RMI4	Trifunctional enzyme subunit alpha, mitochondrial		762	Unreviewed	Mitochondrion inner membrane	fatty acid beta-oxidation	enoyl-CoA hydratase activity | long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity | NAD+ binding | transferase activity	mitochondrial fatty acid beta-oxidation multienzyme complex | mitochondrial inner membrane	Acetylation | Fatty acid metabolism | Lipid metabolism | Lyase | Membrane | Methylation | Mitochondrion | Mitochondrion inner membrane | Multifunctional enzyme | NAD | Oxidoreductase | Phosphoprotein | Transferase | Transit peptide		
Ixodes ricinus	34613	A0A147BVJ2	(3R)-3-hydroxyacyl-CoA dehydrogenase		321	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	V5I2G9	Evasin P1172		94	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL5 and CXCL8
Ixodes ricinus	34613	A0A0K8RK34	Evasin P1086		94	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL10, CXCL12 and CXCL13
Ixodes ricinus	34613	A0A0K8RCU3	Evasin P1168		106	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2 and CXCL8
Ixodes ricinus	34613	A0A0K8R6B3	Evasin P1128		90	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5 and CXCL8
Ixodes ricinus	34613	A0A0K8R5I2	Evasin P942		92	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL10, CXCL11 and CXCL13
Ixodes ricinus	34613	A0A0K8RG61	Evasin P1124		83	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL12 and CXCL13
Ixodes ricinus	34613	A0A0K8RE99	Evasin P1166		110	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2 and CXCL8
Ixodes ricinus	34613	A0A0K8RD51	Evasin P1170		102	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1 and CXCL8
Ixodes ricinus	34613	A0A0K8R4R9	Evasin P1229		108	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1 and CXCL8
Ixodes ricinus	34613	A0A090XA85	Evasin P1104		94	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL12 and CXCL13
Ixodes ricinus	34613	A0A0K8RDH6	Evasin P1074		96	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1 and CXCL8
Ixodes ricinus	34613	A0A0K8RCE3	Evasin P1095		112	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokine CXCL8
Ixodes ricinus	34613	A0A0K8R726	Evasin P1078		96	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL11 and CXCL13
Ixodes ricinus	34613	A0A0K8R556	Evasin P1100		96	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL10, CXCL11 and CXCL13
Ixodes ricinus	34613	A0A0K8RKE4	Evasin P1096		114	Reviewed	Secreted		C-X-C chemokine binding	extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary chemokine-binding protein which binds to host chemokine CXCL8
Ixodes ricinus	34613	A0A147BVN3	(3R)-3-hydroxyacyl-CoA dehydrogenase		290	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8RN22	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A147BW20	(3R)-3-hydroxyacyl-CoA dehydrogenase		297	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A090XFH4	Bifunctional purine biosynthesis protein ATIC		667	Unreviewed	Cytoplasm, cytosol	'de novo' IMP biosynthetic process	IMP cyclohydrolase activity | phosphoribosylaminoimidazolecarboxamide formyltransferase activity	cytosol	Cytoplasm | Hydrolase | Multifunctional enzyme | Purine biosynthesis | Transferase		
Ixodes ricinus	34613	A0A090XF72	Serine/threonine-protein kinase TOR		2282	Unreviewed		negative regulation of macroautophagy | positive regulation of biosynthetic process | regulation of primary metabolic process | TORC1 signaling	ATP binding | protein serine kinase activity | protein serine/threonine kinase activity | protein-containing complex binding	cytoplasm | nucleus | TORC1 complex | TORC2 complex	ATP-binding | Kinase | Nucleotide-binding | Repeat | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A090XEP3	Integrin beta		763	Unreviewed	Cell membrane	cell adhesion mediated by integrin | cell migration | cell-matrix adhesion | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | integrin-mediated signaling pathway	integrin binding | metal ion binding	cell surface | focal adhesion | integrin complex	Calcium | Cell adhesion | Cell membrane | Disulfide bond | EGF-like domain | Glycoprotein | Integrin | Magnesium | Membrane | Metal-binding | Repeat | Signal | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A090XDW0	4-hydroxyphenylpyruvate dioxygenase		347	Unreviewed	Cytoplasm | Endoplasmic reticulum membrane | Golgi apparatus membrane	L-phenylalanine catabolic process | L-tyrosine catabolic process	4-hydroxyphenylpyruvate dioxygenase activity | metal ion binding | protein homodimerization activity	endoplasmic reticulum membrane | Golgi membrane	Cytoplasm | Dioxygenase | Endoplasmic reticulum | Golgi apparatus | Iron | Membrane | Metal-binding | Oxidoreductase | Phenylalanine catabolism | Pyruvate | Repeat | Tyrosine catabolism		Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism
Ixodes ricinus	34613	A0A090XDT7	DNA ligase		695	Unreviewed	Nucleus	cell division | DNA biosynthetic process | DNA recombination | DNA repair | Okazaki fragment processing involved in mitotic DNA replication	ATP binding | DNA binding | DNA ligase (ATP) activity	mitochondrion | nucleus	ATP-binding | Cell cycle | Cell division | DNA damage | DNA recombination | DNA repair | DNA replication | Ligase | Nucleotide-binding | Nucleus		
Ixodes ricinus	34613	A0A090XDH3	All trans-polyprenyl-diphosphate synthase PDSS1		313	Unreviewed	Mitochondrion	isoprenoid biosynthetic process | pheromone biosynthetic process | ubiquinone biosynthetic process	all-trans-decaprenyl-diphosphate synthase activity | metal ion binding	heterotetrameric polyprenyl diphosphate synthase complex	Isoprene biosynthesis | Lipid metabolism | Magnesium | Metal-binding | Mitochondrion | Transferase		Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone. Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively. The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry
Ixodes ricinus	34613	A0A090XD15	calcium/calmodulin-dependent protein kinase		570	Unreviewed		cell communication | memory | regulation of gene expression | signaling	ATP binding | calcium/calmodulin-dependent protein kinase activity | calmodulin binding	axon	ATP-binding | Calmodulin-binding | Kinase | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A090XCM6	CTP synthase		409	Unreviewed		'de novo' CTP biosynthetic process | pyrimidine nucleobase biosynthetic process	ATP binding | CTP synthase activity | identical protein binding | lyase activity	cytoophidium | cytoplasm	ATP-binding | Glutamine amidotransferase | Ligase | Lyase | Nucleotide-binding | Pyrimidine biosynthesis		Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen
Ixodes ricinus	34613	A0A090XCB2	Phosphotransferase		443	Unreviewed		glucose metabolic process | glycolytic process | intracellular glucose homeostasis	ATP binding | D-glucose binding | fructokinase activity | glucokinase activity | mannokinase activity	cytosol | mitochondrion	ATP-binding | Glycolysis | Kinase | Nucleotide-binding | Transferase		Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate
Ixodes ricinus	34613	A0A090XC84	PRKCA-binding protein		367	Unreviewed	Cytoplasm, cytoskeleton | Cytoplasm, perinuclear region | Membrane | Postsynaptic density | Synapse, synaptosome	dendritic spine maintenance | intracellular protein transport | positive regulation of receptor internalization | receptor clustering | regulation of Arp2/3 complex-mediated actin nucleation	actin binding | metal ion binding | phospholipid binding | protein domain specific binding | protein kinase C binding	cytoskeleton | neuron projection | perinuclear region of cytoplasm | plasma membrane | postsynaptic density | postsynaptic early endosome | synaptic vesicle | trans-Golgi network membrane	Actin-binding | Calcium | Cytoplasm | Cytoskeleton | Lipoprotein | Membrane | Metal-binding | Palmitate | Phosphoprotein | Synapse | Synaptosome | Zinc		Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function
Ixodes ricinus	34613	A0A090XC20	ATP-dependent DNA helicase		751	Unreviewed	Nucleus, nucleoplasm	cell division | DNA replication | double-strand break repair via homologous recombination | negative regulation of macromolecule metabolic process | negative regulation of nucleobase-containing compound metabolic process	3'-5' DNA helicase activity | ATP binding | ATP hydrolysis activity | DNA binding | four-way junction helicase activity | metal ion binding	chromosome | cytoplasm | nucleoplasm	ATP-binding | Cell cycle | Cell division | DNA damage | DNA repair | DNA replication | DNA-binding | Helicase | Hydrolase | Isomerase | Metal-binding | Nucleotide-binding | Nucleus | Phosphoprotein | Zinc		
Ixodes ricinus	34613	A0A090XBU5	CCR4-NOT transcription complex subunit 4		543	Unreviewed	Cytoplasm | Nucleus	protein ubiquitination	RNA binding | ubiquitin protein ligase activity | zinc ion binding	CCR4-NOT complex | cytosol | nucleus	Coiled coil | Cytoplasm | Metal-binding | Methylation | Nucleus | Phosphoprotein | RNA-binding | Transferase | Ubl conjugation | Ubl conjugation pathway | Zinc | Zinc-finger		Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy
Ixodes ricinus	34613	A0A090XBQ8	Multiple inositol polyphosphate phosphatase 1		456	Unreviewed	Cell membrane		acid phosphatase activity | bisphosphoglycerate 3-phosphatase activity | inositol phosphate phosphatase activity	plasma membrane	Cell membrane | Disulfide bond | Glycoprotein | Hydrolase | Membrane | Signal		
Ixodes ricinus	34613	A0A090XBK4	Protein CASC3		593	Unreviewed	Cell projection, dendrite | Cytoplasm, Stress granule | Cytoplasm, perinuclear region | Nucleus speckle	mRNA processing | mRNA transport | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | regulation of translation | RNA splicing	mRNA binding	cytoplasmic stress granule | dendrite | exon-exon junction complex | nuclear speck | perinuclear region of cytoplasm | spliceosomal complex	Cell projection | Cytoplasm | mRNA processing | mRNA splicing | mRNA transport | Nonsense-mediated mRNA decay | Nucleus | RNA-binding | Spliceosome | Translation regulation | Transport		
Ixodes ricinus	34613	A0A090XB26	DNA replication licensing factor MCM7	MCM7	718	Unreviewed	Chromosome | Nucleus	DNA replication initiation | DNA strand elongation involved in DNA replication | double-strand break repair via break-induced replication	ATP binding | ATP hydrolysis activity | single-stranded DNA binding | single-stranded DNA helicase activity	chromosome | MCM complex | nucleus	ATP-binding | Cell cycle | Chromosome | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Ubl conjugation		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Ixodes ricinus	34613	A0A090XAY7	DNA replication licensing factor MCM7	MCM7	640	Unreviewed	Chromosome | Nucleus	DNA replication initiation | DNA strand elongation involved in DNA replication | double-strand break repair via break-induced replication	ATP binding | ATP hydrolysis activity | single-stranded DNA binding | single-stranded DNA helicase activity	chromosome | MCM complex | nucleus	ATP-binding | Cell cycle | Chromosome | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Ubl conjugation		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Ixodes ricinus	34613	A0A090XA24	Phosphomannomutase		226	Unreviewed	Cytoplasm	GDP-mannose biosynthetic process | mannose metabolic process | protein N-linked glycosylation	metal ion binding | phosphomannomutase activity	cytosol	Cytoplasm | Isomerase | Magnesium | Metal-binding		Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions
Ixodes ricinus	34613	A0A090X935	Short-chain specific acyl-CoA dehydrogenase, mitochondrial		366	Unreviewed		butyrate catabolic process | fatty acid beta-oxidation using acyl-CoA dehydrogenase	flavin adenine dinucleotide binding | short-chain fatty acyl-CoA dehydrogenase activity	mitochondrion	FAD | Flavoprotein | Oxidoreductase		Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains
Ixodes ricinus	34613	A0A090X909	mitogen-activated protein kinase		359	Unreviewed		cellular response to arsenic-containing substance | cellular response to cadmium ion | cellular response to reactive oxygen species | defense response to bacterium | defense response to fungus | determination of adult lifespan | heart morphogenesis | immune response | paracrine signaling | positive regulation of cell size | regulation of adult chitin-containing cuticle pigmentation | regulation of cellular response to oxidative stress | response to heat | response to hydrogen peroxide | response to osmotic stress | response to starvation	ATP binding | MAP kinase activity		ATP-binding | Kinase | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A090X8W3	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial		492	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	4 iron, 4 sulfur cluster binding | FMN binding | metal ion binding | NAD binding | NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	4Fe-4S | Electron transport | Flavoprotein | FMN | Iron | Iron-sulfur | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Transit peptide | Translocase | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I
Ixodes ricinus	34613	A0A090X8D8	Peroxisomal trans-2-enoyl-CoA reductase		268	Unreviewed	Peroxisome	fatty acid biosynthetic process | phytol metabolic process	trans-2-enoyl-CoA reductase (NADPH) activity	peroxisome	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | NADP | Oxidoreductase | Peroxisome | Phosphoprotein		Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity
Ixodes ricinus	34613	A0A090X7U5	Sodium/potassium-transporting ATPase subunit alpha		939	Unreviewed	Cell membrane	intracellular potassium ion homeostasis | intracellular sodium ion homeostasis | potassium ion import across plasma membrane | proton transmembrane transport | sodium ion export across plasma membrane	ATP binding | ATP hydrolysis activity | metal ion binding | P-type sodium:potassium-exchanging transporter activity	plasma membrane	ATP-binding | Cell membrane | Ion transport | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Potassium | Potassium transport | Sodium | Sodium transport | Sodium/potassium transport | Translocase | Transmembrane | Transmembrane helix | Transport		This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients
Ixodes ricinus	34613	A0A090X7R7	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial		325	Unreviewed	Mitochondrion	tricarboxylic acid cycle	nucleotide binding | succinate-CoA ligase (ADP-forming) activity | succinate-CoA ligase (GDP-forming) activity	mitochondrion | succinate-CoA ligase complex (ADP-forming)	Ligase | Mitochondrion | Nucleotide-binding | Tricarboxylic acid cycle		Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits
Ixodes ricinus	34613	A0A088BD80	Cytochrome c oxidase subunit 1	cox1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ricinus	34613	A0A088BD24	Cytochrome c oxidase subunit 1	cox1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ricinus	34613	A0A088BD09	Cytochrome c oxidase subunit 1	cox1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Ixodes ricinus	34613	V5IJR9	Poly [ADP-ribose] polymerase		936	Unreviewed	Chromosome | Cytoplasm, cytosol | Nucleus, nucleolus	double-strand break repair | innate immune response | protein poly-ADP-ribosylation	DNA binding | NAD+ poly-ADP-ribosyltransferase activity | NAD+-protein-aspartate ADP-ribosyltransferase activity | NAD+-protein-glutamate ADP-ribosyltransferase activity | NAD+-protein-histidine ADP-ribosyltransferase activity | NAD+-protein-serine ADP-ribosyltransferase activity | NAD+-protein-tyrosine ADP-ribosyltransferase activity | nucleotidyltransferase activity | zinc ion binding	chromosome | cytosol | nucleolus	ADP-ribosylation | Allosteric enzyme | Chromosome | Cytoplasm | DNA-binding | Glycosyltransferase | Immunity | Innate immunity | Isopeptide bond | Metal-binding | NAD | Nucleotidyltransferase | Nucleus | Repeat | Transcription | Transcription regulation | Transferase | Zinc | Zinc-finger		
Ixodes ricinus	34613	A0A0K8R2J0	Serine/threonine-protein kinase RIO2		319	Unreviewed	Cytoplasm	maturation of SSU-rRNA	ATP binding | metal ion binding | protein serine/threonine kinase activity	cytosol | nucleus | preribosome, small subunit precursor	ATP-binding | Cytoplasm | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Ribosome biogenesis | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	A0A0K8R2Z9	Acireductone dioxygenase		183	Unreviewed	Cell membrane | Cytoplasm | Nucleus	L-methionine salvage from methylthioadenosine	acireductone dioxygenase (Ni2+-requiring) activity | acireductone dioxygenase [iron(II)-requiring] activity | iron ion binding | nickel cation binding	cytoplasm | nucleus | plasma membrane	Amino-acid biosynthesis | Cytoplasm | Dioxygenase | Iron | Metal-binding | Methionine biosynthesis | Nickel | Nucleus | Oxidoreductase		Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Ixodes ricinus	34613	A0A0K8R3C6	non-specific serine/threonine protein kinase		249	Unreviewed	Nucleus	tRNA processing | tRNA threonylcarbamoyladenosine metabolic process	ATP binding | hydrolase activity | protein serine/threonine kinase activity	cytosol | EKC/KEOPS complex | nucleus	ATP-binding | Hydrolase | Kinase | Nucleotide-binding | Nucleus | Phosphoprotein | Serine/threonine-protein kinase | Transferase | tRNA processing		Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation
Ixodes ricinus	34613	A0A0K8R3C7	Angiotensin-converting enzyme		641	Unreviewed		proteolysis	carboxypeptidase activity | metal ion binding | metallopeptidase activity | peptidyl-dipeptidase activity	plasma membrane	Carboxypeptidase | Disulfide bond | Glycoprotein | Hydrolase | Metal-binding | Metalloprotease | Protease | Signal | Zinc		
Ixodes ricinus	34613	A0A0K8RAF9	Nuclear pore complex protein Nup153		543	Unreviewed	Nucleus membrane | Nucleus, nuclear pore complex	mRNA transport | protein import into nucleus | RNA export from nucleus	DNA binding | nuclear localization sequence binding | structural constituent of nuclear pore | zinc ion binding	nuclear inclusion body | nuclear lumen | nuclear membrane | nuclear pore nuclear basket	DNA-binding | Isopeptide bond | Membrane | Metal-binding | mRNA transport | Nuclear pore complex | Nucleus | Protein transport | Repeat | Translocation | Transport | Ubl conjugation | Zinc | Zinc-finger		Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)
Ixodes ricinus	34613	A0A0K8R9T0	Bifunctional glutamate/proline--tRNA ligase		858	Unreviewed		prolyl-tRNA aminoacylation	ATP binding | glutamate-tRNA ligase activity | metal ion binding | proline-tRNA ligase activity | RNA binding	aminoacyl-tRNA synthetase multienzyme complex | cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Metal-binding | Multifunctional enzyme | Nucleotide-binding | Phosphoprotein | Protein biosynthesis | RNA-binding | Zinc		
Ixodes ricinus	34613	A0A0K8R8Z2	Ras-related protein Rab-24		197	Unreviewed	Cytoplasm, cytoskeleton, spindle | Cytoplasm, cytosol | Cytoplasm, perinuclear region | Cytoplasmic vesicle, autophagosome membrane | Membrane	autophagy | protein transport	G protein activity | GTP binding | metal ion binding	autophagosome membrane | cytoplasmic vesicle | cytosol | perinuclear region of cytoplasm | spindle	Autophagy | Cytoplasm | Cytoplasmic vesicle | Cytoskeleton | GTP-binding | Hydrolase | Lipoprotein | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Prenylation | Protein transport | Transport		The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state. RAB24 is required for the clearance of late autophagic vacuoles under basal conditions. It is not needed for starvation-induced autophagy. Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction
Ixodes ricinus	34613	A0A0K8R8Y5	Ubiquinone biosynthesis O-methyltransferase, mitochondrial		260	Unreviewed	Mitochondrion inner membrane	methylation	3-demethylubiquinol 3-O-methyltransferase activity | 3-demethylubiquinone 3-O-methyltransferase activity | metal ion binding | polyprenyldihydroxybenzoate methyltransferase activity	extrinsic component of mitochondrial inner membrane	Magnesium | Membrane | Metal-binding | Methyltransferase | Mitochondrion | Mitochondrion inner membrane | S-adenosyl-L-methionine | Transferase | Ubiquinone biosynthesis		O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol
Ixodes ricinus	34613	A0A0K8R873	Putative rRNA methyltransferase		820	Unreviewed	Nucleus, nucleolus	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rRNA (guanine) methyltransferase activity | rRNA (uridine-2'-O-)-methyltransferase activity	nucleolus | preribosome, large subunit precursor	Coiled coil | Methyltransferase | Nucleus | Ribosome biogenesis | rRNA processing | S-adenosyl-L-methionine | Transferase		Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits
Ixodes ricinus	34613	A0A0K8R857	Aminopeptidase		778	Unreviewed	Cell membrane | Membrane	peptide catabolic process | proteolysis	alanyl aminopeptidase activity | metalloaminopeptidase activity | peptide binding | zinc ion binding	cytoplasm | extracellular space | plasma membrane | side of membrane	Aminopeptidase | Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipoprotein | Membrane | Metal-binding | Metalloprotease | Protease | Signal | Transmembrane | Transmembrane helix | Zinc		
Ixodes ricinus	34613	A0A0K8R822	Adenylate kinase		253	Unreviewed	Cytoplasm, cytosol | Mitochondrion intermembrane space	ADP biosynthetic process | AMP metabolic process | ATP metabolic process	AMP kinase activity | ATP binding	cytosol | mitochondrial intermembrane space	ATP-binding | Cytoplasm | Kinase | Mitochondrion | Nucleotide-binding | Transferase		Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways
Ixodes ricinus	34613	A0A0K8R813	Ubiquitin-conjugating enzyme E2 C		195	Unreviewed		cell division	ATP binding | ligase activity | ubiquitin conjugating enzyme activity		ATP-binding | Cell cycle | Cell division | Ligase | Mitosis | Nucleotide-binding | Transferase | Ubl conjugation | Ubl conjugation pathway		Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit
Ixodes ricinus	34613	A0A0K8R7X2	Mannosyl-oligosaccharide glucosidase		818	Unreviewed	Endoplasmic reticulum membrane	oligosaccharide metabolic process | protein N-linked glycosylation	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | Glycoprotein | Glycosidase | Hydrolase | Membrane | Signal-anchor | Transmembrane | Transmembrane helix		Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor
Ixodes ricinus	34613	A0A0K8R7T2	Fructose-1,6-bisphosphatase isozyme 2		334	Unreviewed	Cell junction | Cytoplasm, myofibril, sarcomere, Z line | Nucleus	fructose 1,6-bisphosphate metabolic process | fructose 6-phosphate metabolic process | fructose metabolic process | gluconeogenesis | sucrose biosynthetic process	fructose 1,6-bisphosphate 1-phosphatase activity | metal ion binding	anchoring junction | cytosol | nucleus | Z disc	Calcium | Carbohydrate metabolism | Cell junction | Cytoplasm | Hydrolase | Magnesium | Metal-binding | Nucleus | Phosphoprotein		Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate
Ixodes ricinus	34613	A0A0K8R7S7	ATPase ASNA1 homolog		335	Unreviewed	Cytoplasm | Endoplasmic reticulum	tail-anchored membrane protein insertion into ER membrane	ATP binding | ATP hydrolysis activity | metal ion binding	GET complex	ATP-binding | Cytoplasm | Endoplasmic reticulum | Hydrolase | Metal-binding | Nucleotide-binding | Transport | Zinc		ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting
Ixodes ricinus	34613	A0A0K8R7K9	Translin		231	Unreviewed	Cytoplasm | Nucleus	RNA metabolic process	endonuclease activity | hydrolase activity | metal ion binding | RNA binding | sequence-specific DNA binding | single-stranded DNA binding	cytoplasm | nucleus	Cytoplasm | DNA-binding | Endonuclease | Hydrolase | Magnesium | Metal-binding | Nuclease | Nucleus | RNA-binding		DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots
Ixodes ricinus	34613	A0A0K8R7I1	(3R)-3-hydroxyacyl-CoA dehydrogenase		258	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	V5IE19	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN		393	Unreviewed	Cell projection, neuron projection | Cytoplasm	cell motility | negative regulation of cell population proliferation | phosphatidylinositol 3-kinase/protein kinase B signal transduction | phosphatidylinositol dephosphorylation | regulation of developmental process | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | protein serine/threonine phosphatase activity | protein tyrosine phosphatase activity	cytosol | neuron projection | nucleus | plasma membrane	Cell projection | Cytoplasm | Hydrolase | Lipid metabolism | Protein phosphatase		
Ixodes ricinus	34613	A0A0K8R7E2	UMP-CMP kinase		241	Unreviewed	Cytoplasm | Nucleus	'de novo' pyrimidine nucleobase biosynthetic process | pyrimidine nucleotide biosynthetic process	ATP binding | CMP kinase activity | dCMP kinase activity | UMP kinase activity	cytoplasm | nucleus	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Nucleus | Pyrimidine biosynthesis | Transferase		Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors
Ixodes ricinus	34613	A0A0K8R794	Cyclin-dependent kinase 5 homolog		296	Unreviewed		axonogenesis | cell division | neuron apoptotic process | regulation of synapse assembly | synaptic vesicle transport	ATP binding | cyclin-dependent protein serine/threonine kinase activity	cytoplasm | nucleus	ATP-binding | Cell cycle | Cell division | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase		Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Possible regulator of neuronal differentiation and/or development
Ixodes ricinus	34613	A0A0K8R759	U6 snRNA-associated Sm-like protein LSm6		79	Unreviewed	Cytoplasm | Nucleus	maturation of SSU-rRNA | mRNA splicing, via spliceosome | tRNA processing	RNA binding	Lsm2-8 complex | nucleolus | P-body | sno(s)RNA-containing ribonucleoprotein complex | spliceosomal complex | U4/U6 x U5 tri-snRNP complex | U6 snRNP	Cytoplasm | mRNA processing | mRNA splicing | Nucleus | Ribonucleoprotein | RNA-binding | rRNA processing | Spliceosome | tRNA processing		Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome
Ixodes ricinus	34613	A0A0K8R750	Phosphomannomutase		253	Unreviewed	Cytoplasm	GDP-mannose biosynthetic process | mannose metabolic process | protein N-linked glycosylation	metal ion binding | phosphomannomutase activity	cytosol	Cytoplasm | Isomerase | Magnesium | Metal-binding		Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions
Ixodes ricinus	34613	A0A0K8R6W9	Anamorsin homolog		274	Unreviewed	Cytoplasm | Mitochondrion intermembrane space	iron-sulfur cluster assembly	2 iron, 2 sulfur cluster binding | 4 iron, 4 sulfur cluster binding | electron transfer activity | metal ion binding	mitochondrial intermembrane space	2Fe-2S | 4Fe-4S | Cytoplasm | Iron | Iron-sulfur | Metal-binding | Mitochondrion		Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit
Ixodes ricinus	34613	A0A0K8R6K9	N-terminal methionine N(alpha)-acetyltransferase NatC		288	Unreviewed	Cytoplasm | Nucleus		protein N-terminal-methionine acetyltransferase activity	NatC complex | nucleus	Acyltransferase | Cytoplasm | Nucleus | Transferase		
Ixodes ricinus	34613	A0A0K8R6D7	ADP/ATP translocase		299	Unreviewed	Membrane | Mitochondrion inner membrane	mitochondrial ADP transmembrane transport | mitochondrial ATP transmembrane transport | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ATP:ADP antiporter activity	mitochondrial inner membrane	Antiport | Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane
Ixodes ricinus	34613	A0A147BVQ6	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8R666	Deoxyribose-phosphate aldolase		321	Unreviewed	Cytoplasmic granule | Nucleus	carbohydrate catabolic process | deoxyribonucleotide catabolic process | deoxyribose phosphate catabolic process	deoxyribose-phosphate aldolase activity	cytoplasm | nucleus	Cytoplasm | Lyase | Nucleus | Schiff base		Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation
Ixodes ricinus	34613	A0A0K8R4Z9	Molybdenum cofactor biosynthesis protein 1		380	Unreviewed		Mo-molybdopterin cofactor biosynthetic process	4 iron, 4 sulfur cluster binding | cyclic pyranopterin monophosphate synthase activity | GTP 3',8'-cyclase activity | GTP binding | metal ion binding		4Fe-4S | GTP-binding | Iron | Iron-sulfur | Lyase | Metal-binding | Molybdenum cofactor biosynthesis | Nucleotide-binding | S-adenosyl-L-methionine		Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP
Ixodes ricinus	34613	A0A0K8R4W2	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1		392	Unreviewed	Membrane		glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity | manganese ion binding | nucleotide binding	membrane	Disulfide bond | Glycoprotein | Glycosyltransferase | Manganese | Membrane | Metal-binding | Nucleotide-binding | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins
Ixodes ricinus	34613	A0A0K8R4R6	Isocitrate dehydrogenase [NADP]		412	Unreviewed		glyoxylate cycle | isocitrate metabolic process | NADP+ metabolic process | tricarboxylic acid cycle	isocitrate dehydrogenase (NADP+) activity | magnesium ion binding | NAD binding	cytosol | mitochondrion | peroxisome	Glyoxylate bypass | Magnesium | Manganese | Metal-binding | NADP | Oxidoreductase | Tricarboxylic acid cycle		
Ixodes ricinus	34613	A0A0K8R4N8	Dual specificity protein phosphatase		192	Unreviewed		negative regulation of MAPK cascade	MAP kinase phosphatase activity | protein serine/threonine phosphatase activity | protein tyrosine phosphatase activity | protein tyrosine/serine/threonine phosphatase activity	cytoplasm	Hydrolase | Protein phosphatase		Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate
Ixodes ricinus	34613	A0A0K8R3P5	Phosphoenolpyruvate carboxykinase [GTP]		670	Unreviewed		cellular response to glucose stimulus | gluconeogenesis | glycerol biosynthetic process from pyruvate | oxaloacetate metabolic process | propionate catabolic process | response to lipid | response to starvation	GTP binding | kinase activity | manganese ion binding | phosphoenolpyruvate carboxykinase (GTP) activity	cytosol	Decarboxylase | GTP-binding | Kinase | Lyase | Manganese | Metal-binding | Nucleotide-binding | Pyruvate | Transferase		Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle
Ixodes ricinus	34613	A0A0K8R798	Nucleotide triphosphate diphosphatase NUDT15		250	Unreviewed		dGTP catabolic process | response to stress	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity | metal ion binding	cytosol	Coiled coil | Hydrolase | Magnesium | Manganese | Metal-binding		May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear. Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs. May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro
Ixodes ricinus	34613	V5ICK3	Lysosomal dipeptide transporter MFSD1		521	Unreviewed	Lysosome membrane		transmembrane transporter activity	lysosomal membrane	Lysosome | Membrane | Signal | Sugar transport | Transmembrane | Transmembrane helix | Transport		Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis
Ixodes ricinus	34613	A0A0K8R685	(3R)-3-hydroxyacyl-CoA dehydrogenase		310	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Ixodes ricinus	34613	V5I5V8	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		128	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	A0A6B0VCL9	PRKCA-binding protein		493	Unreviewed	Cytoplasm, cytoskeleton | Cytoplasm, perinuclear region | Membrane | Postsynaptic density | Synapse, synaptosome	dendritic spine maintenance | intracellular protein transport | positive regulation of receptor internalization | receptor clustering | regulation of Arp2/3 complex-mediated actin nucleation	actin binding | metal ion binding | phospholipid binding | protein domain specific binding | protein kinase C binding	cytoskeleton | neuron projection | perinuclear region of cytoplasm | plasma membrane | postsynaptic density | postsynaptic early endosome | synaptic vesicle | trans-Golgi network membrane	Actin-binding | Calcium | Cytoplasm | Cytoskeleton | Lipoprotein | Membrane | Metal-binding | Palmitate | Phosphoprotein | Synapse | Synaptosome | Zinc		Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function
Ixodes ricinus	34613	A0A6B0VCA9	Glucosylceramidase		525	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Signal | Sphingolipid metabolism		
Ixodes ricinus	34613	A0A6B0VB58	PRKCA-binding protein		384	Unreviewed	Cytoplasm, cytoskeleton | Cytoplasm, perinuclear region | Membrane | Postsynaptic density | Synapse, synaptosome	dendritic spine maintenance | intracellular protein transport | positive regulation of receptor internalization | receptor clustering | regulation of Arp2/3 complex-mediated actin nucleation	actin binding | metal ion binding | phospholipid binding | protein domain specific binding | protein kinase C binding	cytoskeleton | neuron projection | perinuclear region of cytoplasm | plasma membrane | postsynaptic density | postsynaptic early endosome | synaptic vesicle | trans-Golgi network membrane	Actin-binding | Calcium | Cytoplasm | Cytoskeleton | Lipoprotein | Membrane | Metal-binding | Palmitate | Phosphoprotein | Synapse | Synaptosome | Zinc		Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function
Ixodes ricinus	34613	A0A6B0V9S0	(3R)-3-hydroxyacyl-CoA dehydrogenase		298	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V9I3	(3R)-3-hydroxyacyl-CoA dehydrogenase		293	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V951	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V941	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V8V7	(3R)-3-hydroxyacyl-CoA dehydrogenase		282	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V8T7	(3R)-3-hydroxyacyl-CoA dehydrogenase		310	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V8M7	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V8J8	(3R)-3-hydroxyacyl-CoA dehydrogenase		298	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V898	(3R)-3-hydroxyacyl-CoA dehydrogenase		293	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V843	(3R)-3-hydroxyacyl-CoA dehydrogenase		298	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V827	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V814	(3R)-3-hydroxyacyl-CoA dehydrogenase		296	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V7X3	(3R)-3-hydroxyacyl-CoA dehydrogenase		293	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V7W8	(3R)-3-hydroxyacyl-CoA dehydrogenase		293	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V7T1	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V7L7	(3R)-3-hydroxyacyl-CoA dehydrogenase		297	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V7I9	(3R)-3-hydroxyacyl-CoA dehydrogenase		295	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V759	(3R)-3-hydroxyacyl-CoA dehydrogenase		312	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V6Y7	(3R)-3-hydroxyacyl-CoA dehydrogenase		298	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V6T6	(3R)-3-hydroxyacyl-CoA dehydrogenase		301	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V6L1	(3R)-3-hydroxyacyl-CoA dehydrogenase		297	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V6E3	(3R)-3-hydroxyacyl-CoA dehydrogenase		293	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0V4H1	glycerophosphocholine cholinephosphodiesterase		251	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Ixodes ricinus	34613	A0A147BW47	(3R)-3-hydroxyacyl-CoA dehydrogenase		321	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A6B0VD69	Diacylglycerol lipase-alpha		624	Unreviewed	Cell projection, dendritic spine membrane | Early endosome membrane | Postsynaptic density membrane	arachidonate metabolic process | diacylglycerol catabolic process | retrograde trans-synaptic signaling by endocannabinoid	lipoprotein lipase activity | metal ion binding | monoacylglycerol lipase activity	dendritic spine membrane | early endosome membrane | postsynaptic density membrane	Calcium | Cell membrane | Cell projection | Endosome | Glycoprotein | Hydrolase | Lipid degradation | Lipid metabolism | Membrane | Metal-binding | Phosphoprotein | Postsynaptic cell membrane | Synapse | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	A0A6B0VDK3	glycerophosphocholine cholinephosphodiesterase		471	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Ixodes ricinus	34613	A0A6B0VB87	Lysosomal dipeptide transporter MFSD1		484	Unreviewed	Lysosome membrane		transmembrane transporter activity	lysosomal membrane	Lysosome | Membrane | Sugar transport | Transmembrane | Transmembrane helix | Transport		Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis
Ixodes ricinus	34613	A0A6B0VG03	Uncharacterized protein		2258	Unreviewed	Cytoplasm	'de novo' pyrimidine nucleobase biosynthetic process | 'de novo' UMP biosynthetic process | glutamine metabolic process | L-arginine biosynthetic process	amino acid binding | aspartate carbamoyltransferase activity | ATP binding | carbamoyl-phosphate synthase (ammonia) activity | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | dihydroorotase activity | glutaminase activity | metal ion binding	carbamoyl-phosphate synthase complex	Allosteric enzyme | ATP-binding | Cytoplasm | Glutamine amidotransferase | Hydrolase | Ligase | Metal-binding | Multifunctional enzyme | Nucleotide-binding | Phosphoprotein | Pyrimidine biosynthesis | Repeat | Transferase | Zinc		Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate
Ixodes ricinus	34613	V5I3G8	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		1044	Unreviewed		cell migration | phagocytosis | phosphatidylinositol 3-kinase/protein kinase B signal transduction | phosphatidylinositol-mediated signaling	1-phosphatidylinositol-3-kinase activity | 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity | 1-phosphatidylinositol-4-phosphate 3-kinase activity | ATP binding | protein serine kinase activity | protein serine/threonine kinase activity	cytoplasm | phosphatidylinositol 3-kinase complex | plasma membrane	Angiogenesis | ATP-binding | Kinase | Nucleotide-binding | Phagocytosis | Serine/threonine-protein kinase | Transferase		
Ixodes ricinus	34613	V5I1W4	Flavin-containing monooxygenase		540	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Ixodes ricinus	34613	V5I0E4	Katanin p60 ATPase-containing subunit A1	KATNA1	508	Unreviewed	Cytoplasm, cytoskeleton, spindle | Cytoplasm | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Cytoplasm, cytoskeleton, spindle pole	cell division | microtubule severing	ATP binding | ATP hydrolysis activity | microtubule binding | microtubule severing ATPase activity	centrosome | cytoplasm | microtubule | spindle pole	ATP-binding | Cell cycle | Cell division | Cytoplasm | Cytoskeleton | Isomerase | Microtubule | Mitosis | Nucleotide-binding		Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation
Ixodes ricinus	34613	V5I001	RING-type E3 ubiquitin transferase		2224	Unreviewed	Cytoplasm, myofibril | Nucleus	animal organ development | chromatin organization | locomotion | muscle contraction | myosin filament organization | sarcomere organization | system development	actin filament binding | ATP binding | identical protein binding | microfilament motor activity | structural constituent of muscle | ubiquitin protein ligase activity | zinc ion binding	A band | myosin filament | myosin II complex | nucleus	Actin-binding | ATP-binding | Chromatin regulator | Coiled coil | Cytoplasm | Metal-binding | Motor protein | Muscle protein | Myosin | Nucleotide-binding | Nucleus | Thick filament | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		
Ixodes ricinus	34613	V5HWT6	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		145	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	V5HWL8	Acylglycerol kinase, mitochondrial		452	Unreviewed	Mitochondrion inner membrane | Mitochondrion intermembrane space	ceramide biosynthetic process | glycerolipid metabolic process | sphingosine biosynthetic process	acylglycerol kinase activity | ATP binding | ATP-dependent diacylglycerol kinase activity | ceramide kinase activity	mitochondrial inner membrane | mitochondrial intermembrane space	ATP-binding | Kinase | Lipid metabolism | Membrane | Mitochondrion | Mitochondrion inner membrane | Nucleotide-binding | Transferase		
Ixodes ricinus	34613	V5HRT6	Histone acetyltransferase		440	Unreviewed	Mitochondrion | Nucleus	DNA repair-dependent chromatin remodeling | epigenetic regulation of gene expression | hemopoiesis | negative regulation of multicellular organismal process | neurogenesis | regulation of cell differentiation | regulation of mitochondrial transcription	histone H4K16 acetyltransferase activity | protein propionyltransferase activity | zinc ion binding	H3 histone acetyltransferase complex | mitochondrion | MSL complex | NSL complex | NuA4 histone acetyltransferase complex | nucleus | polytene chromosome interband	Acetylation | Activator | Chromatin regulator | Metal-binding | Mitochondrion | Nucleus | Phosphoprotein | Transcription | Transcription regulation | Transferase | Zinc | Zinc-finger		
Ixodes ricinus	34613	V5HKL2	DNA oxidative demethylase ALKBH2		214	Unreviewed	Nucleus, nucleolus | Nucleus, nucleoplasm	DNA alkylation repair	broad specificity oxidative DNA demethylase activity | cytosine C-5 DNA demethylase activity | ferrous iron binding	nucleolus | nucleoplasm	Dioxygenase | DNA damage | DNA repair | Iron | Magnesium | Metal-binding | Nucleus | Oxidoreductase		
Ixodes ricinus	34613	V5HKI9	Histone acetyltransferase		441	Unreviewed	Mitochondrion | Nucleus	DNA repair-dependent chromatin remodeling | epigenetic regulation of gene expression | hemopoiesis | negative regulation of multicellular organismal process | neurogenesis | regulation of cell differentiation | regulation of mitochondrial transcription	histone H4K16 acetyltransferase activity | protein propionyltransferase activity | zinc ion binding	mitochondrion | MSL complex | NSL complex | NuA4 histone acetyltransferase complex | nucleus | polytene chromosome interband	Acetylation | Activator | Chromatin regulator | Metal-binding | Mitochondrion | Nucleus | Phosphoprotein | Transcription | Transcription regulation | Transferase | Zinc | Zinc-finger		
Ixodes ricinus	34613	A0A6B0VDK6	PRKCA-binding protein		429	Unreviewed	Cytoplasm, cytoskeleton | Cytoplasm, perinuclear region | Membrane | Postsynaptic density | Synapse, synaptosome	dendritic spine maintenance | intracellular protein transport | positive regulation of receptor internalization | receptor clustering | regulation of Arp2/3 complex-mediated actin nucleation	actin binding | metal ion binding | phospholipid binding | protein domain specific binding | protein kinase C binding	cytoskeleton | neuron projection | perinuclear region of cytoplasm | plasma membrane | postsynaptic density | postsynaptic early endosome | synaptic vesicle | trans-Golgi network membrane	Actin-binding | Calcium | Cytoplasm | Cytoskeleton | Lipoprotein | Membrane | Metal-binding | Palmitate | Phosphoprotein | Synapse | Synaptosome | Zinc		Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function
Ixodes ricinus	34613	V5HIY1	Glutamate synthase [NADH]		2048	Unreviewed		ammonia assimilation cycle | L-glutamate biosynthetic process	3 iron, 4 sulfur cluster binding | flavin adenine dinucleotide binding | FMN binding | glutamate synthase (NADH) activity | glutamate synthase (NADPH) activity | iron ion binding | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor		3Fe-4S | Amino-acid biosynthesis | Coiled coil | FAD | Flavoprotein | FMN | Glutamate biosynthesis | Glutamine amidotransferase | Iron | Iron-sulfur | Metal-binding | Oxidoreductase		Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate
Ixodes ricinus	34613	V5HID3	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		143	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	V5HI41	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		248	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	V5HE32	(3R)-3-hydroxyacyl-CoA dehydrogenase		299	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	V5HJ99	Putative multifunctional pyrimidine synthesis protein cad includes carbamoyl-phosphate synthetase		2232	Unreviewed	Cytoplasm	'de novo' pyrimidine nucleobase biosynthetic process | 'de novo' UMP biosynthetic process | glutamine metabolic process | L-arginine biosynthetic process	amino acid binding | aspartate carbamoyltransferase activity | ATP binding | carbamoyl-phosphate synthase (ammonia) activity | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | dihydroorotase activity | glutaminase activity | metal ion binding	carbamoyl-phosphate synthase complex	Allosteric enzyme | ATP-binding | Cytoplasm | Glutamine amidotransferase | Hydrolase | Ligase | Metal-binding | Multifunctional enzyme | Nucleotide-binding | Phosphoprotein | Pyrimidine biosynthesis | Repeat | Transferase | Zinc		Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate
Ixodes ricinus	34613	V5HBI3	(3R)-3-hydroxyacyl-CoA dehydrogenase		295	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	A0A0K8RB76	Adenylate kinase isoenzyme 6 homolog		176	Unreviewed	Cytoplasm | Nucleus	ribosomal small subunit biogenesis | rRNA processing	AMP kinase activity | ATP binding | ATP hydrolysis activity	cytoplasm | nucleus	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Nucleus | Ribosome biogenesis | rRNA processing | Transferase		Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis
Ixodes ricinus	34613	V5HBR3	Putative multifunctional pyrimidine synthesis protein cad includes carbamoyl-phosphate synthetase		1694	Unreviewed		'de novo' pyrimidine nucleobase biosynthetic process | 'de novo' UMP biosynthetic process | citrulline biosynthetic process | glutamine metabolic process | UTP biosynthetic process	amino acid binding | aspartate carbamoyltransferase activity | ATP binding | carbamoyl-phosphate synthase (ammonia) activity | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | dihydroorotase activity | glutaminase activity | metal ion binding	cytosol	ATP-binding | Glutamine amidotransferase | Hydrolase | Ligase | Metal-binding | Multifunctional enzyme | Nucleotide-binding | Pyrimidine biosynthesis | Repeat | Transferase		
Ixodes ricinus	34613	V5GH83	Flavin-containing monooxygenase		546	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Ixodes ricinus	34613	V5GJT4	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		259	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	V5GQT3	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		130	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Ixodes ricinus	34613	V5GW05	glycerophosphocholine cholinephosphodiesterase		454	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Ixodes ricinus	34613	V5GEN9	(3R)-3-hydroxyacyl-CoA dehydrogenase		308	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Signal		
Ixodes ricinus	34613	V5IB92	Lateral signaling target protein 2 homolog		691	Unreviewed	Membrane	glycerophospholipid biosynthetic process | midbody abscission | phosphatidylinositol dephosphorylation | regulation of autophagy	molecular adaptor activity | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | phosphatidylinositol-3-phosphate phosphatase activity | phosphoprotein phosphatase activity | protein phosphatase binding | zinc ion binding	cytosol | membrane	Coiled coil | Hydrolase | Lipid metabolism | Membrane | Metal-binding | Signal | Zinc | Zinc-finger		Negative regulator of epidermal growth factor receptor (EGFR) signaling
Ixodes ricinus	34613	V5GY83	Lysosomal dipeptide transporter MFSD1		349	Unreviewed	Lysosome membrane		transmembrane transporter activity	lysosomal membrane	Lysosome | Membrane | Sugar transport | Transmembrane | Transmembrane helix | Transport		Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis
Ixodes ricinus	34613	V5GWN7	Glucosylceramidase		525	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Signal | Sphingolipid metabolism		
Ixodes ricinus	34613	V5H3X1	(3R)-3-hydroxyacyl-CoA dehydrogenase		333	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Membrane | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Transmembrane | Transmembrane helix		
Ixodes ricinus	34613	V5H536	Potassium channel subfamily K member 1		334	Unreviewed	Apical cell membrane | Cell membrane | Cell projection, dendrite | Cytoplasmic vesicle | Perikaryon | Recycling endosome | Synaptic cell membrane	stabilization of membrane potential	outward rectifier potassium channel activity | potassium ion leak channel activity	apical plasma membrane | dendrite | perikaryon | recycling endosome | synaptic membrane	Cell membrane | Cell projection | Cytoplasmic vesicle | Disulfide bond | Endosome | Glycoprotein | Ion channel | Ion transport | Isopeptide bond | Membrane | Potassium | Potassium channel | Potassium transport | Synapse | Transmembrane | Transmembrane helix | Transport | Ubl conjugation		
Ixodes ricinus	34613	V5H946	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		259	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Nosomma monstrosum	72866	Q9MCZ8	Cytochrome c oxidase subunit 1	COI	263	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Nosomma monstrosum	72866	A0A240EVQ1	Histone H3	H3	89	Unreviewed			DNA binding | protein heterodimerization activity | structural constituent of chromatin	nucleosome	Chromosome | DNA-binding | Nucleosome core | Nucleus		
Nosomma monstrosum	72866	A0A219XBE2	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Otobius megnini	34606	W0FDI1	NADH-ubiquinone oxidoreductase chain 4L	NAD4L	92	Unreviewed	Membrane		NADH dehydrogenase (ubiquinone) activity	membrane	Membrane | Mitochondrion | NAD | Translocase | Transmembrane | Transmembrane helix		
Otobius megnini	34606	W0FGP5	NADH dehydrogenase subunit 6	NAD6	145	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Otobius megnini	34606	W0FIB9	NADH-ubiquinone oxidoreductase chain 4	NAD4	440	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Otobius megnini	34606	W0FHV9	Cytochrome b	CYTB	367	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Otobius megnini	34606	W0FHV4	NADH-ubiquinone oxidoreductase chain 3	NAD3	112	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Otobius megnini	34606	W0FGP2	Cytochrome c oxidase subunit 3	COX3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Otobius megnini	34606	W0FGN9	NADH-ubiquinone oxidoreductase chain 2	NAD2	318	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Otobius megnini	34606	W0FIB4	ATP synthase subunit 8	ATP8	51	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Otobius megnini	34606	W0FDH6	ATP synthase subunit a	ATP6	222	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Otobius megnini	34606	W0FDE8	NADH-ubiquinone oxidoreductase chain 5	NAD5	551	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Otobius megnini	34606	W0FDE3	Cytochrome c oxidase subunit 2	COX2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Otobius megnini	34606	W0FHU8	Cytochrome c oxidase subunit 1	COX1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Otobius megnini	34606	A0A4Y5S354	Cytochrome c oxidase subunit 1	COI	216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Otobius megnini	34606	A0A4Y5S2R2	Cytochrome c oxidase subunit 1	CO1	218	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Otobius megnini	34606	A0A2I7YUL4	Cytochrome c oxidase subunit 1	COI	220	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Otobius megnini	34606	W0FDF3	NADH-ubiquinone oxidoreductase chain 1	NAD1	305	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus annulatus	34611	A0A7T3PLY8	Cytochrome b	cytB	209	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus annulatus	34611	B0LAI9	Glutathione S-transferase	GSTmu	223	Unreviewed		glutathione metabolic process	glutathione transferase activity		Transferase		Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Rhipicephalus annulatus	34611	S5M1T7	Cytochrome b	cytB	208	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus annulatus	34611	S5MPN1	Cytochrome b	cytB	208	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus annulatus	34611	V9MLH4	Cytochrome b	CYTB	235	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus annulatus	34611	V9MLX3	NADH-ubiquinone oxidoreductase chain 3	NAD3	113	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Rhipicephalus annulatus	34611	V9MLS8	Cytochrome c oxidase subunit 2	COX2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	V9MLT3	NADH-ubiquinone oxidoreductase chain 1	NAD1	312	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus annulatus	34611	A0A386IRV8	Gamma-aminobutyric acid receptor subunit beta		332	Unreviewed	Postsynaptic cell membrane		chloride channel activity | extracellular ligand-gated monoatomic ion channel activity | GABA-A receptor activity | ligand-gated monoatomic anion channel activity	chloride channel complex | postsynaptic membrane	Cell membrane | Chloride | Chloride channel | Disulfide bond | Glycoprotein | Ion channel | Ion transport | Ligand-gated ion channel | Membrane | Postsynaptic cell membrane | Receptor | Signal | Synapse | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus annulatus	34611	V9MMB8	NADH-ubiquinone oxidoreductase chain 2	NAD2	318	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus annulatus	34611	V9MMB9	Cytochrome c oxidase subunit 3	COX3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	V9MLH9	ATP synthase subunit a	ATP6	223	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus annulatus	34611	A0A385L562	Cytochrome c oxidase subunit 1	COI	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A385KLJ3	Cytochrome c oxidase subunit 1		212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A385KLJ4	Cytochrome c oxidase subunit 1		214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A060AF96	Sodium channel protein		68	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus annulatus	34611	A0A385KLJ1	Cytochrome c oxidase subunit 1		211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A385KLI9	Cytochrome c oxidase subunit 1		215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A385KLI6	Cytochrome c oxidase subunit 1		213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A385GKT3	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GJX1	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GJW9	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GJV9	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GJV8	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GJT8	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GJL0	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GJK1	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GJF3	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385KLJ7	Cytochrome c oxidase subunit 1		214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A068BCL6	Sodium channel		67	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus annulatus	34611	A0A386IRV6	Voltage-gated sodium channel		206	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus annulatus	34611	A0A0A1EIJ3	Cathepsin L-like protein		332	Unreviewed		proteolysis	cysteine-type peptidase activity		Disulfide bond | Hydrolase | Protease | Signal | Thiol protease | Zymogen		
Rhipicephalus annulatus	34611	A0A385GJE5	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	V9MM82	ATP synthase subunit 8	ATP8	52	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus annulatus	34611	S5MQV1	Salivary protein Sal3		220	Unreviewed					Signal		
Rhipicephalus annulatus	34611	S5MKN4	Salivary protein Sal1		176	Unreviewed					Signal		
Rhipicephalus annulatus	34611	S5M6X0	Salivary protein Sal4		186	Unreviewed					Signal		
Rhipicephalus annulatus	34611	S4U8E0	Subolesin		147	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Rhipicephalus annulatus	34611	R4R030	Carboxyl esterase		124	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Glycoprotein | Hydrolase | Serine esterase		
Rhipicephalus annulatus	34611	Q9U780	Ba99	Ba99	35	Unreviewed							
Rhipicephalus annulatus	34611	Q8HKH3	NADH dehydrogenase subunit 1	ND1	17	Unreviewed					Mitochondrion		
Rhipicephalus annulatus	34611	M1LER7	Sodium channel protein		67	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus annulatus	34611	M1L2U5	Sodium channel		67	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus annulatus	34611	K7XR79	Carboxylesterase		124	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Glycoprotein | Hydrolase | Serine esterase		
Rhipicephalus annulatus	34611	K0DGA5	Carboxyl esterase		124	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Glycoprotein | Hydrolase | Serine esterase		
Rhipicephalus annulatus	34611	E5KCI9	Bm86 glycoprotein		647	Unreviewed					Signal		
Rhipicephalus annulatus	34611	E5KCI7	Bm86 glycoprotein		647	Unreviewed					Signal		
Rhipicephalus annulatus	34611	E5D575	ATAQ protein		605	Unreviewed					Membrane | Signal | Transmembrane | Transmembrane helix		
Rhipicephalus annulatus	34611	E0YPC0	Small heat shock protein II		180	Unreviewed		protein refolding | response to heat	unfolded protein binding	cytoplasm | nucleus	Stress response		
Rhipicephalus annulatus	34611	D2CXW9	Bm86-like protein		648	Unreviewed					Signal		
Rhipicephalus annulatus	34611	C4NAM9	Bm86-like protein Ba86		609	Unreviewed							
Rhipicephalus annulatus	34611	B2BZV8	BA86-like protein		609	Unreviewed							
Rhipicephalus annulatus	34611	B1NNT8	Secreted protein		171	Unreviewed					Signal		
Rhipicephalus annulatus	34611	A0A8K1W5P8	Voltage dependent anion-selective channel		282	Unreviewed	Mitochondrion outer membrane		porin activity | voltage-gated monoatomic anion channel activity	mitochondrial outer membrane | pore complex	Ion transport | Membrane | Mitochondrion | Mitochondrion outer membrane | Porin | Transmembrane | Transmembrane beta strand | Transport		
Rhipicephalus annulatus	34611	A0A8E4MHM0	Defensin	anuln	74	Unreviewed	Secreted	defense response to bacterium		extracellular region	Antibiotic | Antimicrobial | Cleavage on pair of basic residues | Defensin | Disulfide bond | Secreted | Signal		
Rhipicephalus annulatus	34611	A0A6C0PQ76	Voltage-gated sodium channel		55	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus annulatus	34611	A0A6C0PQ70	Para-sodium channel		55	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus annulatus	34611	A0A6B9SM69	Para-sodium channel		104	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus annulatus	34611	A0A6B9SLU6	Para-sodium channel		123	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus annulatus	34611	A0A6B9SLI5	Para-sodium channel		44	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus annulatus	34611	A0A386IRV4	Voltage-gated sodium channel		34	Unreviewed	Membrane		monoatomic ion channel activity	membrane	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus annulatus	34611	A0A068BE71	Carboxyl esterase		124	Unreviewed					Glycoprotein		
Rhipicephalus annulatus	34611	A0A385GJB7	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	S5M306	Salivary protein Sal2		211	Unreviewed					Signal		
Rhipicephalus annulatus	34611	A0A385GJ92	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A6H0QVM7	Cytochrome c oxidase subunit 1	COI	189	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A6H0QVL9	Cytochrome c oxidase subunit 1	COI	175	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A6H0QUJ1	Cytochrome c oxidase subunit 1	COX1	226	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A6H0QUI6	Cytochrome c oxidase subunit 1	COX1	340	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Sodium | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A6G9DSR9	Cytochrome c oxidase subunit 1	COX1	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A5B9RB38	Cytochrome c oxidase subunit 1	COI	208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A5B9R318	Cytochrome c oxidase subunit 1	COI	207	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A5B9R1H5	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A5B9QYX4	Cytochrome c oxidase subunit 1	COI	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A5B9QYT7	Cytochrome c oxidase subunit 1	COI	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A482K1B9	Cytochrome c oxidase subunit 1	COI	224	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A482K097	Cytochrome c oxidase subunit 1	COI	224	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A385L589	Cytochrome c oxidase subunit 1	COI	216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A6H0QVS4	Cytochrome c oxidase subunit 1	COI	198	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A385JPJ3	Cytochrome c oxidase subunit 1	COI	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A385JPE1	Cytochrome c oxidase subunit 1	COI	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A1V0QHW1	Cytochrome c oxidase subunit 1		146	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A1Q1M937	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A1P8SGN4	Cytochrome c oxidase subunit 1	cox1	347	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A1P8SGM9	Cytochrome c oxidase subunit 1	cox1	347	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A1P8SGM8	Cytochrome c oxidase subunit 1	cox1	351	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A1P8SGM0	Cytochrome c oxidase subunit 1	cox1	341	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A1P8SGL7	Cytochrome c oxidase subunit 1	cox1	341	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A385GJB0	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A0B5EAS5	Cytochrome c oxidase subunit 1		512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding | oxidoreductase activity	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A0A7M8R6	Cytochrome c oxidase subunit 1		512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A0A0RAU5	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A059VIA9	Cytochrome c oxidase subunit 1	COI	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A385JPE4	Cytochrome c oxidase subunit 1	COI	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A6H0QY22	Cytochrome c oxidase subunit 1	COI	189	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A6H0QVM2	Cytochrome c oxidase subunit 1	COI	175	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A7G3QPM7	Cytochrome c oxidase subunit 1	COX1	196	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A385GJ81	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GIZ8	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GIY8	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GIY7	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GIX4	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GIW0	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GIU1	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A385GIS6	Carboxylic ester hydrolase	AChE1	592	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus annulatus	34611	A0A346HX61	Sodium channel protein		301	Unreviewed	Cell membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Cell membrane | Disulfide bond | Ion channel | Ion transport | Membrane | Repeat | Sodium | Sodium channel | Sodium transport | Transmembrane | Transmembrane helix | Transport | Voltage-gated channel		Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient
Rhipicephalus annulatus	34611	A0A2I4K5F2	Histone H2A	H2A.Z	128	Unreviewed	Chromosome | Nucleus		DNA binding | protein heterodimerization activity | structural constituent of chromatin	nucleosome | nucleus	Chromosome | DNA-binding | Isopeptide bond | Nucleosome core | Nucleus		
Rhipicephalus annulatus	34611	A0A2I4K5B6	Histone H2A	H2A.X	138	Unreviewed	Chromosome | Nucleus		DNA binding | protein heterodimerization activity | structural constituent of chromatin	nucleosome | nucleus	Acetylation | Chromosome | DNA-binding | Isopeptide bond | Nucleosome core | Nucleus		Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Rhipicephalus annulatus	34611	A0A6M4EKK8	Cytochrome c oxidase subunit 1	COI	158	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A1V0QHZ7	Cytochrome c oxidase subunit 1		263	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A0A0N845	Small heat shock protein I	HSPI	180	Unreviewed		protein refolding | response to heat	unfolded protein binding	cytoplasm | nucleus	Stress response		
Rhipicephalus annulatus	34611	V9MLX0	Cytochrome c oxidase subunit 1	COX1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A2I4K566	Histone H2A	H2A	124	Unreviewed	Chromosome | Nucleus		DNA binding | protein heterodimerization activity | structural constituent of chromatin	nucleosome | nucleus	Chromosome | DNA-binding | Isopeptide bond | Nucleosome core | Nucleus		Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Rhipicephalus annulatus	34611	U5MYE0	Cytochrome c oxidase subunit 1	COX1	223	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A7G3QPQ1	Cytochrome c oxidase subunit 1	COX1	195	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A7S9AUA1	Cytochrome c oxidase subunit 1	COXI	167	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	U5N0W4	Cytochrome c oxidase subunit 1	COX1	229	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A8F4X544	Cytochrome c oxidase subunit 1	COX1	269	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A8F4X5D5	Cytochrome c oxidase subunit 1	COX1	268	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A8F4X6U1	Cytochrome c oxidase subunit 1	COX1	268	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A8F4X532	Cytochrome c oxidase subunit 1	COX1	268	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A8F4X7D1	Cytochrome c oxidase subunit 1	COX1	269	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A8K1KXD1	Cytochrome c oxidase subunit 1	COX1	245	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	J9ZZ53	Cytochrome c oxidase subunit 1	COI	246	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	Q64K94	Calreticulin		411	Unreviewed	Endoplasmic reticulum lumen	ERAD pathway | protein folding	calcium ion binding | carbohydrate binding | unfolded protein binding	endoplasmic reticulum lumen | endoplasmic reticulum membrane	Calcium | Chaperone | Disulfide bond | Endoplasmic reticulum | Lectin | Metal-binding | Repeat | Signal | Zinc		Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER
Rhipicephalus annulatus	34611	Q9MD05	Cytochrome c oxidase subunit 1	COI	264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus annulatus	34611	A0A8F4X6V1	Cytochrome c oxidase subunit 1	COX1	269	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus bursa	67831	U5N0X1	Cytochrome c oxidase subunit 1	COX1	229	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus bursa	67831	U5MYB2	Cytochrome c oxidase subunit 1	COX1	229	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus bursa	67831	S5MJC6	Cytochrome b	cytB	208	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus bursa	67831	S5M7K7	Cytochrome b	cytB	208	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus bursa	67831	S5M1U2	Cytochrome b	cytB	201	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus bursa	67831	G4WEQ2	Cytochrome c oxidase subunit 2	COXII	171	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus bursa	67831	A0A1V0QHX3	Cytochrome c oxidase subunit 1		263	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus bursa	67831	U5MXQ3	Cytochrome c oxidase subunit 1	COX1	229	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus bursa	67831	A0A7T3PLY7	Cytochrome b	cytB	209	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus bursa	67831	A0A6M3VX58	Cytochrome c oxidase subunit 1	COI	178	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus bursa	67831	A0A6H0PZ94	Cytochrome c oxidase subunit 1	COX1	280	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus bursa	67831	M1T1C6	Cytochrome c oxidase subunit 1	COXI	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus bursa	67831	A0A6G9DT36	Cytochrome c oxidase subunit 1	COX1	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus bursa	67831	A0A2I4KEA6	Cytochrome c oxidase subunit 1	COI	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus bursa	67831	A0A2I4KE64	Cytochrome c oxidase subunit 1	COI	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus bursa	67831	A0A0A7MB34	Cytochrome c oxidase subunit 1		512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus bursa	67831	Q5EPH2	Carboxypeptidase inhibitor		97	Reviewed	Secreted	acquisition of nutrients from host	enzyme inhibitor activity | metalloendopeptidase inhibitor activity | toxin activity	extracellular region	3D-structure | Direct protein sequencing | Fibrinolytic toxin | Hemostasis impairing toxin | Metalloenzyme inhibitor | Metalloprotease inhibitor | Protease inhibitor | Secreted | Signal | Toxin	1ZLH | 1ZLI | 2JTO | 2K2X | 2K2Y | 2K2Z | 3D4U | 3LMS | 3OSL	Potent competitive inhibitor of metallo-carboxypeptidases CPA1, CPA2, CPB, CPN, and TAF1a (PubMed:15561703). Also inhibits human CPA4 (PubMed:20385563). Accelerates fibrinolysis in vitro and may contribute to the maintenance of host blood liquidity during feeding (PubMed:15561703)
Rhipicephalus decoloratus	60189	A0A1W6FBE7	Carboxylesterase protein		123	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Glycoprotein | Hydrolase | Serine esterase		
Rhipicephalus decoloratus	60189	A0A1W6FBE6	Carboxylesterase protein		123	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Glycoprotein | Hydrolase | Serine esterase		
Rhipicephalus decoloratus	60189	A0A1W6FBE5	Para-sodium channel protein		55	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus decoloratus	60189	A0A1W6FBE2	Para-sodium channel protein		55	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus decoloratus	60189	A0A1W6FBD9	Para-sodium channel protein		55	Unreviewed	Membrane	membrane depolarization during action potential | neuronal action potential	voltage-gated sodium channel activity	voltage-gated sodium channel complex	Ion channel | Ion transport | Membrane | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus decoloratus	60189	A0A8K1KWG8	Cytochrome c oxidase subunit 1	COX1	243	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A8K1NSX1	Cytochrome c oxidase subunit 1	COX1	242	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A1W6FBE8	Carboxylesterase protein		123	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Glycoprotein | Hydrolase | Serine esterase		
Rhipicephalus decoloratus	60189	A0A7G9TYN2	NADH-ubiquinone oxidoreductase chain 2	NAD2	318	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus decoloratus	60189	A0A7G9TYN1	Cytochrome b	CYTB	358	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus decoloratus	60189	A0A7G9TYM8	NADH-ubiquinone oxidoreductase chain 4	NAD4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus decoloratus	60189	O61987	Carboxylic ester hydrolase	AChE	590	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Disulfide bond | Glycoprotein | Hydrolase | Neurotransmitter degradation | Serine esterase | Signal		Rapidly hydrolyzes choline released into the synapse
Rhipicephalus decoloratus	60189	A0A1W6FBE9	Carboxylesterase protein		123	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Glycoprotein | Hydrolase | Serine esterase		
Rhipicephalus decoloratus	60189	A0A7G9TYM9	NADH dehydrogenase subunit 4L	NAD4L	91	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus decoloratus	60189	A0A1W6FBG5	Carboxylesterase protein		123	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Glycoprotein | Hydrolase | Serine esterase		
Rhipicephalus decoloratus	60189	A0A7G9TYM2	ATP synthase subunit 8	ATP8	51	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus decoloratus	60189	A0A7G9TYN0	NADH dehydrogenase subunit 6	NAD6	149	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus decoloratus	60189	A0A8J9SDA5	Carboxylesterase		123	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Glycoprotein | Hydrolase | Serine esterase		
Rhipicephalus decoloratus	60189	A0A8J9WT51	Octopamine/tyramine receptor		80	Unreviewed					Membrane | Receptor | Transmembrane | Transmembrane helix		
Rhipicephalus decoloratus	60189	A1XQW0	Intestinal cell surface glycoprotein		615	Unreviewed							
Rhipicephalus decoloratus	60189	A1XQW1	Intestinal cell surface glycoprotein		616	Unreviewed							
Rhipicephalus decoloratus	60189	B2BZV9	BD86-like protein		615	Unreviewed							
Rhipicephalus decoloratus	60189	E5D576	ATAQ protein		605	Unreviewed					Membrane | Signal | Transmembrane | Transmembrane helix		
Rhipicephalus decoloratus	60189	Q8HKH0	NADH dehydrogenase subunit 5	ND5	113	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus decoloratus	60189	Q8HKH1	NADH dehydrogenase subunit 1	ND1	37	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus decoloratus	60189	Q8HKH2	NADH dehydrogenase subunit 1	ND1	17	Unreviewed					Mitochondrion		
Rhipicephalus decoloratus	60189	S4UAH0	Subolesin		147	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Rhipicephalus decoloratus	60189	A0A1W6FBF2	Carboxylesterase protein		123	Unreviewed		acetylcholine catabolic process | choline metabolic process	acetylcholinesterase activity	extracellular space | plasma membrane	Glycoprotein | Hydrolase | Serine esterase		
Rhipicephalus decoloratus	60189	A0A7G9TYM6	NADH-ubiquinone oxidoreductase chain 1	NAD1	312	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus decoloratus	60189	A0A7G9TYM7	NADH-ubiquinone oxidoreductase chain 5	NAD5	552	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus decoloratus	60189	A0A7G9TYM4	Cytochrome c oxidase subunit 3	COX3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A0U2EYM6	Cytochrome c oxidase subunit 1	Cox1	207	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A0U2EYQ1	Cytochrome c oxidase subunit 1	Cox1	210	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A0U2EYR1	Cytochrome c oxidase subunit 1	Cox1	218	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A0U2EYR4	Cytochrome c oxidase subunit 1	Cox1	218	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A0U2EYS1	Cytochrome c oxidase subunit 1	Cox1	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A0U2EYW6	Cytochrome c oxidase subunit 1	Cox1	216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A482K0W3	Cytochrome c oxidase subunit 1	COI	227	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A482K2G6	Cytochrome c oxidase subunit 1	COI	226	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A7G9TYM5	NADH-ubiquinone oxidoreductase chain 3	NAD3	113	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Rhipicephalus decoloratus	60189	A0A5B9R1P9	Cytochrome c oxidase subunit 1	COI	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A5B9RB26	Cytochrome c oxidase subunit 1	COI	198	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A6G7PSG8	Cytochrome c oxidase subunit 1	COX1	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A6G7PT71	Cytochrome c oxidase subunit 1	COX1	208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A513U4L2	Cytochrome c oxidase subunit 1	CO1	181	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A8F0F2H1	Cytochrome c oxidase subunit 1	COX1	195	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A7G9TYM0	Cytochrome c oxidase subunit 1	COX1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A7G9TYM1	Cytochrome c oxidase subunit 2	COX2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A7D5D0F6	Subolesin	sub	161	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Rhipicephalus decoloratus	60189	A0A5J6DXU1	Glutathione S-transferase	GST	223	Unreviewed		glutathione metabolic process	glutathione transferase activity		Transferase		Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Rhipicephalus decoloratus	60189	A0A1V0QI16	Cytochrome c oxidase subunit 1		262	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A1V0QI12	Cytochrome c oxidase subunit 1		263	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A7G9TYM3	ATP synthase subunit a	ATP6	223	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus decoloratus	60189	A0A1V0QI06	Cytochrome c oxidase subunit 1		262	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A1V0QHX0	Cytochrome c oxidase subunit 1		263	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	Q9MD04	Cytochrome c oxidase subunit 1	COI	264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A8F0JVI9	Cytochrome c oxidase subunit 1	COX1	195	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A8F0F2I0	Cytochrome c oxidase subunit 1	COX1	195	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus decoloratus	60189	A0A1V0QI08	Cytochrome c oxidase subunit 1		257	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus geigyi	136141	V9MMB3	NADH-ubiquinone oxidoreductase chain 2	NAD2	318	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus geigyi	136141	V9MMB5	Cytochrome c oxidase subunit 3	COX3	259	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus geigyi	136141	V9MMD9	Cytochrome c oxidase subunit 2	COX2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus geigyi	136141	V9MME0	NADH-ubiquinone oxidoreductase chain 1	NAD1	312	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus geigyi	136141	Q8HKG9	NADH dehydrogenase subunit 3	ND3	27	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus geigyi	136141	Q8HKG8	NADH dehydrogenase subunit 1	ND1	17	Unreviewed					Mitochondrion		
Rhipicephalus geigyi	136141	V9MLR4	NADH dehydrogenase subunit 6	NAD6	149	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus geigyi	136141	V9MM31	ATP synthase subunit 8	ATP8	51	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus geigyi	136141	V9MM34	NADH-ubiquinone oxidoreductase chain 5	NAD5	552	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus geigyi	136141	V9MME1	Cytochrome b	CYTB	358	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus geigyi	136141	V9MLZ6	NADH-ubiquinone oxidoreductase chain 4	NAD4	438	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus geigyi	136141	V9MMB7	NADH dehydrogenase subunit 4L	NAD4L	91	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus geigyi	136141	V9MLQ9	NADH-ubiquinone oxidoreductase chain 3	NAD3	113	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Rhipicephalus geigyi	136141	V9MLZ1	ATP synthase subunit a	ATP6	223	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus geigyi	136141	A0A7G3QKI5	Cytochrome c oxidase subunit 1	COX1	196	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus geigyi	136141	A0A7G3QKK9	Cytochrome c oxidase subunit 1	COX1	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus geigyi	136141	A0A7G3QMI9	Cytochrome c oxidase subunit 1	COX1	195	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus geigyi	136141	A0A1Q1M933	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus geigyi	136141	A0A7G3QN90	Cytochrome c oxidase subunit 1	COX1	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus geigyi	136141	Q94S24	Cytochrome c oxidase subunit 1	COI	254	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus geigyi	136141	V9MLQ5	Cytochrome c oxidase subunit 1	COX1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus geigyi	136141	A0A1V0QHW9	Cytochrome c oxidase subunit 1		263	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus geigyi	136141	A0A7G3QMJ9	Cytochrome c oxidase subunit 1	COX1	205	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus haemaphysaloides	237073	A0A7L7SEU2	Serpin 11	RHS11	413	Unreviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Glycoprotein | Protease inhibitor | Secreted | Serine protease inhibitor | Signal		
Rhipicephalus haemaphysaloides	237073	A0A6C0M8T6	Serpin 8		403	Unreviewed	Secreted	immune system process	serine-type endopeptidase inhibitor activity | toxin activity	extracellular space	Blood coagulation cascade inhibiting toxin | Glycoprotein | Hemostasis impairing toxin | Immunity | Protease inhibitor | Secreted | Serine protease inhibitor | Signal | Toxin		
Rhipicephalus haemaphysaloides	237073	A0A7L7S552	Serpin 4	RHS4	399	Unreviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Glycoprotein | Protease inhibitor | Secreted | Serine protease inhibitor | Signal		
Rhipicephalus haemaphysaloides	237073	A0A7L7S5V5	Serpin 7	RHS7	395	Unreviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Glycoprotein | Protease inhibitor | Secreted | Serine protease inhibitor		
Rhipicephalus haemaphysaloides	237073	A0A7L7S5Y8	Serpin 3	RHS3	380	Unreviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Glycoprotein | Protease inhibitor | Secreted | Serine protease inhibitor		
Rhipicephalus haemaphysaloides	237073	A0A7L7S8W2	Serpin 10	RHS10	376	Unreviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Glycoprotein | Protease inhibitor | Secreted | Serine protease inhibitor		
Rhipicephalus haemaphysaloides	237073	A0A7L7SBD6	Serpin 9	RHS9	379	Unreviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Glycoprotein | Protease inhibitor | Secreted | Serine protease inhibitor		
Rhipicephalus haemaphysaloides	237073	A0A7L7SG95	Serpin 6	RHS6	399	Unreviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Glycoprotein | Protease inhibitor | Secreted | Serine protease inhibitor		
Rhipicephalus haemaphysaloides	237073	E7DT70	Cysteine-rich antimicrobial peptide	rhamp	100	Unreviewed					Signal		
Rhipicephalus haemaphysaloides	237073	A0A977TN71	Bax		216	Unreviewed		extrinsic apoptotic signaling pathway in absence of ligand | intrinsic apoptotic signaling pathway in response to DNA damage | regulation of apoptotic process | release of cytochrome c from mitochondria	BH domain binding	mitochondrial outer membrane	Apoptosis | Membrane | Transmembrane | Transmembrane helix		
Rhipicephalus haemaphysaloides	237073	A0A977TNF3	Apoptosis regulator Bcl-2-like protein		192	Unreviewed	Membrane	extrinsic apoptotic signaling pathway in absence of ligand | intrinsic apoptotic signaling pathway in response to DNA damage | regulation of apoptotic process | release of cytochrome c from mitochondria	BH domain binding	mitochondrial outer membrane	Apoptosis | Membrane		
Rhipicephalus haemaphysaloides	237073	D9IFL4	Actin		376	Unreviewed	Cytoplasm, cytoskeleton	anatomical structure formation involved in morphogenesis | cell development	ATP binding | hydrolase activity	cytoskeleton	Acetylation | ATP-binding | Cytoplasm | Cytoskeleton | Hydrolase | Nucleotide-binding | Oxidation		
Rhipicephalus haemaphysaloides	237073	A0A5C0ZWE6	Vitellogenin-3		1533	Unreviewed			lipid transporter activity | nutrient reservoir activity		Disulfide bond | Glycoprotein | Signal | Storage protein		
Rhipicephalus haemaphysaloides	237073	K7WSB5	Serpin 1		403	Unreviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Glycoprotein | Protease inhibitor | Secreted | Serine protease inhibitor | Signal		
Rhipicephalus haemaphysaloides	237073	K7X6U2	Serpin 2		380	Unreviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Glycoprotein | Protease inhibitor | Secreted | Serine protease inhibitor		
Rhipicephalus haemaphysaloides	237073	Q1ZZW9	Metalloproteinase		468	Unreviewed		membrane protein ectodomain proteolysis	metal ion binding | metalloendopeptidase activity		Hydrolase | Metal-binding | Metalloprotease | Protease | Signal | Zinc		
Rhipicephalus haemaphysaloides	237073	A0A7T7JNU1	Caspase9		360	Unreviewed		apoptotic process | proteolysis	cysteine-type endopeptidase activity		Apoptosis | Hydrolase | Protease | Thiol protease | Zymogen		
Rhipicephalus haemaphysaloides	237073	A0A5C0ZU70	Vitellogenin-1		1270	Unreviewed			lipid transporter activity | nutrient reservoir activity		Disulfide bond | Glycoprotein | Signal | Storage protein		
Rhipicephalus haemaphysaloides	237073	A0A7L7SCS0	Serpin 5	RHS5	399	Unreviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Glycoprotein | Protease inhibitor | Secreted | Serine protease inhibitor | Signal		
Rhipicephalus haemaphysaloides	237073	A0A5C0ZRA8	Vitellogenin-4		1761	Unreviewed			lipid transporter activity | nutrient reservoir activity		Disulfide bond | Glycoprotein | Signal | Storage protein		
Rhipicephalus haemaphysaloides	237073	A0A5C0ZTD3	Vitellogenin-2		1548	Unreviewed			lipid transporter activity | nutrient reservoir activity		Disulfide bond | Glycoprotein | Signal | Storage protein		
Rhipicephalus haemaphysaloides	237073	D9IFL3	Anticoagulant protein rhipilin-1		164	Reviewed	Secreted		serine-type endopeptidase inhibitor activity | toxin activity	extracellular region	Blood coagulation cascade inhibiting toxin | Disulfide bond | Hemostasis impairing toxin | Protease inhibitor | Secreted | Serine protease inhibitor | Signal | Toxin		Anticoagulant protein that may inhibit serine proteases. The anticoagulant effect of this recombinant protein on blood clotting is found both in the recalcification time (RT) and the activated partial thromboplastin time (APTT) tests, indicating it acts in the common pathway of blood coagulation
Rhipicephalus haemaphysaloides	237073	I6VXS1	Anticoagulant protein rhipilin-2		195	Reviewed	Secreted		serine-type endopeptidase inhibitor activity | toxin activity	extracellular space	Blood coagulation cascade inhibiting toxin | Disulfide bond | Hemostasis impairing toxin | Protease inhibitor | Secreted | Serine protease inhibitor | Signal | Toxin		Anticoagulant protein that inhibits the serine proteases trypsin and elastase, but not thrombin (PubMed:25708749). The anticoagulant effect of this recombinant protein on blood clotting is found only in the activated partial thromboplastin time (APTT) assays, but not in the prothrombin time (PT) assays (PubMed:25708749)
Rhipicephalus haemaphysaloides	237073	A0A097J9B4	Cytochrome c oxidase subunit 1	COI	252	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus haemaphysaloides	237073	A0A7G3ZQZ7	Cytochrome c oxidase subunit 1	COX1	223	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus haemaphysaloides	237073	A0A7G3ZQZ8	Cytochrome c oxidase subunit 1	COX1	223	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus haemaphysaloides	237073	A0A7G3ZQZ9	Cytochrome c oxidase subunit 1	COX1	223	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus haemaphysaloides	237073	A0A7G9XUK1	Cytochrome c oxidase subunit 1	COX1	223	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus haemaphysaloides	237073	A0A7S9AUA4	Cytochrome c oxidase subunit 1	COXI	226	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus haemaphysaloides	237073	A0A346LU01	Cytochrome c oxidase subunit 1	COI	197	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus haemaphysaloides	237073	A0A0P0D331	60S acidic ribosomal protein P0		318	Unreviewed		cytoplasmic translation | ribosomal large subunit assembly	large ribosomal subunit rRNA binding | structural constituent of ribosome	cytosolic large ribosomal subunit	Phosphoprotein | Ribonucleoprotein | Ribosomal protein		Ribosomal protein P0 is the functional equivalent of E.coli protein L10
Rhipicephalus haemaphysaloides	237073	A0A5C0ZSP2	Heat shock protein 70 kDa		659	Unreviewed	Endoplasmic reticulum lumen		ATP binding | ATP-dependent protein folding chaperone	endoplasmic reticulum lumen	ATP-binding | Coiled coil | Endoplasmic reticulum | Nucleotide-binding | Signal | Stress response		
Rhipicephalus haemaphysaloides	237073	A0A097BQ10	Subolesin		161	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Rhipicephalus haemaphysaloides	237073	A0A0A7MBH9	Cystatin type 1		98	Unreviewed	Cytoplasm		cysteine-type endopeptidase inhibitor activity	cytosol	Cytoplasm | Protease inhibitor | Thiol protease inhibitor		
Rhipicephalus haemaphysaloides	237073	A0A0A7MGQ1	Cystatin type 2		139	Unreviewed	Secreted		cysteine-type endopeptidase inhibitor activity	cytoplasm | extracellular space | vesicle	Protease inhibitor | Secreted | Signal | Thiol protease inhibitor		
Rhipicephalus haemaphysaloides	237073	A0A0H3WJP2	Subolesin		161	Unreviewed	Nucleus	positive regulation of innate immune response | positive regulation of transcription by RNA polymerase II	transcription coregulator activity	chromatin | nucleus	Nucleus		
Rhipicephalus haemaphysaloides	237073	A0A7S9FU16	Cytochrome c oxidase subunit 1	COXI	228	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus haemaphysaloides	237073	A0A0N7AP63	Cysteine-rich antimicrobial peptide		110	Unreviewed					Signal		
Rhipicephalus microplus	6941	A0A6M2CMS5	Serine/threonine-protein kinase RIO3		461	Unreviewed	Cytoplasm	defense response to virus | innate immune response | ribosome biogenesis	ATP binding | metal ion binding | protein serine/threonine kinase activity	cytoplasm	Antiviral defense | ATP-binding | Cytoplasm | Immunity | Innate immunity | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Ribosome biogenesis | Serine/threonine-protein kinase | Transferase		
Rhipicephalus microplus	6941	A0A6M2CM65	ATP-dependent DNA helicase II subunit 2		708	Unreviewed	Nucleus	DNA recombination | double-strand break repair via nonhomologous end joining | telomere maintenance	ATP binding | damaged DNA binding | DNA helicase activity | double-stranded DNA binding | hydrolase activity | kinase activity | telomeric DNA binding	Ku70:Ku80 complex	ATP-binding | DNA damage | DNA recombination | DNA repair | DNA-binding | Helicase | Hydrolase | Kinase | Nucleotide-binding | Nucleus | Transferase		Single-stranded DNA-dependent ATP-dependent helicase
Rhipicephalus microplus	6941	A0A6M2CM67	RNA helicase		631	Unreviewed		mRNA splicing, via spliceosome	ATP binding | hydrolase activity | JUN kinase binding | RNA binding | RNA helicase activity | zinc ion binding	nucleus | P granule	ATP-binding | Coiled coil | Helicase | Hydrolase | Metal-binding | Nucleotide-binding | RNA-binding | Zinc | Zinc-finger		
Rhipicephalus microplus	6941	A0A6M2CM77	2-hydroxyacyl-CoA lyase 1		574	Unreviewed	Peroxisome	fatty acid alpha-oxidation	2-hydroxyacyl-CoA lyase activity | magnesium ion binding | thiamine pyrophosphate binding	peroxisome	Fatty acid metabolism | Lipid metabolism | Lyase | Magnesium | Membrane | Metal-binding | Peroxisome | Phosphoprotein | Thiamine pyrophosphate | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6M2CM91	Serine hydroxymethyltransferase		482	Unreviewed		glycine biosynthetic process from serine | methylation | tetrahydrofolate interconversion	glycine hydroxymethyltransferase activity | methyltransferase activity | pyridoxal phosphate binding	mitochondrion | nucleus	Methyltransferase | One-carbon metabolism | Pyridoxal phosphate | Transferase		Interconversion of serine and glycine
Rhipicephalus microplus	6941	A0A6M2CMB0	5-demethoxyubiquinone hydroxylase, mitochondrial		209	Unreviewed	Mitochondrion inner membrane	determination of adult lifespan | regulation of gene expression | regulation of reactive oxygen species metabolic process | ubiquinone biosynthetic process	3-demethoxyubiquinol 3-hydroxylase activity | metal ion binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	extrinsic component of mitochondrial inner membrane | nucleus	Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Monooxygenase | Oxidoreductase | Ubiquinone biosynthesis		Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner
Rhipicephalus microplus	6941	A0A6M2CMG1	Cytosol aminopeptidase		525	Unreviewed		proteolysis	manganese ion binding | metalloaminopeptidase activity	cytoplasm	Aminopeptidase | Hydrolase | Protease		Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status
Rhipicephalus microplus	6941	A0A6M2CME1	ADP-ribosylhydrolase ARH3		310	Unreviewed	Chromosome | Cytoplasm | Mitochondrion matrix | Nucleus	DNA repair | peptidyl-serine ADP-deribosylation	metal ion binding | poly(ADP-ribose) glycohydrolase activity	chromosome | mitochondrial matrix | nucleus	Chromosome | Cytoplasm | DNA damage | DNA repair | Hydrolase | Magnesium | Metal-binding | Mitochondrion | Nucleus		
Rhipicephalus microplus	6941	A0A6M2CMP0	Lysine--tRNA ligase		580	Unreviewed	Cell membrane | Cytoplasm, cytosol | Nucleus | Secreted	lysyl-tRNA aminoacylation	ATP binding | lysine-tRNA ligase activity | transferase activity | tRNA binding	aminoacyl-tRNA synthetase multienzyme complex | cytosol | extracellular region | mitochondrion | nucleus | plasma membrane	Acetylation | Aminoacyl-tRNA synthetase | ATP-binding | Cell membrane | Cytoplasm | Ligase | Membrane | Nucleotide-binding | Nucleus | Phosphoprotein | Protein biosynthesis | Secreted | Transferase		Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity
Rhipicephalus microplus	6941	A0A6M2CMP1	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase		379	Unreviewed	Endoplasmic reticulum membrane	fatty acid elongation | sphingolipid biosynthetic process | very long-chain fatty acid biosynthetic process	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	endoplasmic reticulum membrane	Coiled coil | Endoplasmic reticulum | Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Lyase | Membrane | Transmembrane | Transmembrane helix		Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators
Rhipicephalus microplus	6941	A0A6M2CM63	Citramalyl-CoA lyase, mitochondrial		335	Unreviewed	Mitochondrion	regulation of cobalamin metabolic process	(S)-citramalyl-CoA lyase activity | hydrolase activity | malate synthase activity | metal ion binding	mitochondrion	Acetylation | Hydrolase | Lyase | Magnesium | Metal-binding | Mitochondrion | Transferase | Transit peptide		Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro
Rhipicephalus microplus	6941	A0A6M2CKQ2	Fructose-1,6-bisphosphatase isozyme 2		370	Unreviewed	Cell junction | Cytoplasm, myofibril, sarcomere, Z line | Nucleus	fructose 1,6-bisphosphate metabolic process | fructose 6-phosphate metabolic process | fructose metabolic process | gluconeogenesis | sucrose biosynthetic process	fructose 1,6-bisphosphate 1-phosphatase activity | metal ion binding	anchoring junction | cytosol | nucleus | Z disc	Calcium | Carbohydrate metabolism | Cell junction | Cytoplasm | Hydrolase | Magnesium | Metal-binding | Nucleus | Phosphoprotein		Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate
Rhipicephalus microplus	6941	A0A6M2CM31	mitogen-activated protein kinase		355	Unreviewed		cellular response to arsenic-containing substance | cellular response to cadmium ion | cellular response to reactive oxygen species | defense response to bacterium | defense response to fungus | determination of adult lifespan | heart morphogenesis | immune response | paracrine signaling | positive regulation of cell size | regulation of adult chitin-containing cuticle pigmentation | regulation of cellular response to oxidative stress | response to heat | response to hydrogen peroxide | response to osmotic stress | response to starvation	ATP binding | MAP kinase activity		ATP-binding | Kinase | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Transferase		
Rhipicephalus microplus	6941	A0A6M2CKY2	Dual specificity protein phosphatase		192	Unreviewed		negative regulation of MAPK cascade	MAP kinase phosphatase activity | protein serine/threonine phosphatase activity | protein tyrosine phosphatase activity | protein tyrosine/serine/threonine phosphatase activity	cytoplasm	Hydrolase | Protein phosphatase		Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate
Rhipicephalus microplus	6941	A0A6M2CLY6	Adenylosuccinate lyase		478	Unreviewed		'de novo' AMP biosynthetic process | 'de novo' IMP biosynthetic process	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	cytosol	Lyase | Purine biosynthesis		Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate
Rhipicephalus microplus	6941	A0A6M2CLW3	Purine nucleoside phosphorylase		317	Unreviewed		nucleoside metabolic process	purine-nucleoside phosphorylase activity	cytoplasm	Coiled coil | Glycosyltransferase | Transferase		
Rhipicephalus microplus	6941	A0A6M2CLM4	Max-like protein X		240	Unreviewed	Cytoplasm | Nucleus	positive regulation of transcription by RNA polymerase II	DNA-binding transcription factor activity, RNA polymerase II-specific | DNA-binding transcription factor binding | protein dimerization activity | RNA polymerase II cis-regulatory region sequence-specific DNA binding	cytoplasm | nucleoplasm	Activator | Coiled coil | Cytoplasm | DNA-binding | Nucleus | Phosphoprotein | Repressor | Transcription | Transcription regulation		Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation
Rhipicephalus microplus	6941	A0A6M2CLM2	Methyltransferase HEMK2		216	Unreviewed	Nucleus	methylation	nucleic acid binding | protein-glutamine N-methyltransferase activity	eRF1 methyltransferase complex | nucleus	Methyltransferase | Nucleus | S-adenosyl-L-methionine | Transferase		Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT
Rhipicephalus microplus	6941	A0A6M2CLB9	Cytosol aminopeptidase		524	Unreviewed		proteolysis	manganese ion binding | metalloaminopeptidase activity	cytoplasm	Aminopeptidase | Hydrolase | Protease		Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status
Rhipicephalus microplus	6941	A0A6M2CLB1	ornithine decarboxylase		476	Unreviewed		putrescine biosynthetic process from arginine, via ornithine	ornithine decarboxylase activity	cytoplasm	Lyase | Polyamine biosynthesis | Pyridoxal phosphate		Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis
Rhipicephalus microplus	6941	A0A6M2CL45	(3R)-3-hydroxyacyl-CoA dehydrogenase		281	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6M2CKX0	Adenylate kinase		252	Unreviewed	Cytoplasm, cytosol | Mitochondrion intermembrane space	ADP biosynthetic process | AMP metabolic process | ATP metabolic process	AMP kinase activity | ATP binding	cytosol | mitochondrial intermembrane space	ATP-binding | Cytoplasm | Kinase | Mitochondrion | Nucleotide-binding | Transferase		Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways
Rhipicephalus microplus	6941	A0A6M2CKU4	Glyceraldehyde-3-phosphate dehydrogenase		334	Unreviewed	Cytoplasm	glucose metabolic process | glyceraldehyde-3-phosphate metabolic process | glycolytic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | NAD binding | NADP binding	cytosol	Cytoplasm | Glycolysis | NAD | Nucleotide-binding | Oxidoreductase		
Rhipicephalus microplus	6941	A0A6M2CKU0	Purine nucleoside phosphorylase		296	Unreviewed		nucleoside metabolic process	purine-nucleoside phosphorylase activity	cytoplasm	Coiled coil | Glycosyltransferase | Transferase		The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Rhipicephalus microplus	6941	A0A6M2CKS0	3'(2'),5'-bisphosphate nucleotidase 1		321	Unreviewed		phosphatidylinositol phosphate biosynthetic process	3'(2'),5'-bisphosphate nucleotidase activity | inositol-1,4-bisphosphate 1-phosphatase activity | metal ion binding		Hydrolase | Lithium | Magnesium | Metal-binding		
Rhipicephalus microplus	6941	A0A6M2CMT0	Alanine--tRNA ligase		967	Unreviewed		alanyl-tRNA aminoacylation	alanine-tRNA ligase activity | aminoacyl-tRNA deacylase activity | ATP binding | tRNA binding | zinc ion binding	mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Coiled coil | Cytoplasm | Ligase | Metal-binding | Nucleotide-binding | Protein biosynthesis | RNA-binding | tRNA-binding | Zinc		Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain
Rhipicephalus microplus	6941	A0A6M2CM11	Mitochondrial 2-oxodicarboxylate carrier		338	Unreviewed	Mitochondrion inner membrane	transmembrane transport		mitochondrial inner membrane	Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle
Rhipicephalus microplus	6941	A0A6M2CMT8	Vacuolar protein sorting-associated protein 35		818	Unreviewed	Cytoplasm | Early endosome | Late endosome | Membrane	neurotransmitter receptor transport, endosome to plasma membrane | positive regulation of gene expression | positive regulation of signal transduction | regulation of developmental process | regulation of postsynapse organization | regulation of protein catabolic process | regulation of protein localization | regulation of protein stability | regulation of transport | retrograde transport, endosome to Golgi	D1 dopamine receptor binding	cytosol | early endosome | late endosome | retromer, cargo-selective complex	Cytoplasm | Endosome | Membrane | Phosphoprotein | Protein transport | Transport		Plays a role in vesicular protein sorting
Rhipicephalus microplus	6941	A0A6M2CQ15	(3R)-3-hydroxyacyl-CoA dehydrogenase		286	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6M2CMX5	IST1 homolog		341	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Cytoplasmic vesicle | Midbody | Nucleus envelope	cell division | protein transport		centrosome | cytoplasmic vesicle | midbody | nuclear envelope	Cell cycle | Cell division | Coiled coil | Cytoplasm | Cytoplasmic vesicle | Cytoskeleton | Nucleus | Phosphoprotein		ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST
Rhipicephalus microplus	6941	A0A6M2CQJ2	rRNA 2'-O-methyltransferase fibrillarin		274	Unreviewed	Nucleus, nucleolus	box C/D sno(s)RNA 3'-end processing	histone H2AQ104 methyltransferase activity | RNA binding | rRNA methyltransferase activity	box C/D methylation guide snoRNP complex | Cajal body | small-subunit processome	Methyltransferase | Nucleus | Ribonucleoprotein | RNA-binding | rRNA processing | S-adenosyl-L-methionine | Transferase		S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus
Rhipicephalus microplus	6941	A0A6M2CQI9	Serine/threonine-protein kinase PRP4 homolog		544	Unreviewed	Chromosome, centromere, kinetochore | Nucleus	mRNA cis splicing, via spliceosome	ATP binding | protein serine/threonine kinase activity	kinetochore | spliceosomal complex	Acetylation | ATP-binding | Chromosome | Isopeptide bond | Kinase | Kinetochore | mRNA processing | mRNA splicing | Nucleotide-binding | Nucleus | Phosphoprotein | Serine/threonine-protein kinase | Spliceosome | Transferase | Ubl conjugation		
Rhipicephalus microplus	6941	A0A6M2CQG3	Isobutyryl-CoA dehydrogenase, mitochondrial		411	Unreviewed		branched-chain amino acid catabolic process | lipid metabolic process	flavin adenine dinucleotide binding | short-chain 2-methyl fatty acyl-CoA dehydrogenase activity	mitochondrion	Branched-chain amino acid catabolism | FAD | Flavoprotein | Oxidoreductase		Isobutyryl-CoA dehydrogenase which catalyzes the conversion of 2-methylpropanoyl-CoA to (2E)-2-methylpropenoyl-CoA in the valine catabolic pathway. To a lesser extent, also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA
Rhipicephalus microplus	6941	A0A6M2CQF1	Mannosyl-oligosaccharide glucosidase		818	Unreviewed	Endoplasmic reticulum membrane	oligosaccharide metabolic process | protein N-linked glycosylation	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | Glycoprotein | Glycosidase | Hydrolase | Membrane | Signal-anchor | Transmembrane | Transmembrane helix		Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor
Rhipicephalus microplus	6941	A0A6M2CQ77	Phosphotransferase		474	Unreviewed		glucose metabolic process | glycolytic process | intracellular glucose homeostasis	ATP binding | D-glucose binding | fructokinase activity | glucokinase activity	cytosol | mitochondrion	ATP-binding | Glycolysis | Kinase | Nucleotide-binding | Transferase		Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate
Rhipicephalus microplus	6941	A0A6M2CQ67	Peroxisomal trans-2-enoyl-CoA reductase		298	Unreviewed	Peroxisome	fatty acid biosynthetic process | phytol metabolic process	trans-2-enoyl-CoA reductase (NADPH) activity	peroxisome	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | NADP | Oxidoreductase | Peroxisome | Phosphoprotein		Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity
Rhipicephalus microplus	6941	A0A6M2CKQ1	glucose-6-phosphate 1-epimerase		279	Unreviewed		galactose metabolic process	aldose 1-epimerase activity | carbohydrate binding | glucose-6-phosphate 1-epimerase activity	cytoplasm	Isomerase		Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose
Rhipicephalus microplus	6941	A0A6M2CPY7	Anamorsin homolog		278	Unreviewed	Cytoplasm | Mitochondrion intermembrane space	iron-sulfur cluster assembly	2 iron, 2 sulfur cluster binding | 4 iron, 4 sulfur cluster binding | electron transfer activity | metal ion binding	mitochondrial intermembrane space	2Fe-2S | 4Fe-4S | Cytoplasm | Iron | Iron-sulfur | Metal-binding | Mitochondrion		Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit
Rhipicephalus microplus	6941	A0A6M2CPY3	NAD(P) transhydrogenase, mitochondrial		1075	Unreviewed	Cell inner membrane | Mitochondrion inner membrane	NADPH regeneration	NADP binding | proton-translocating NAD(P)+ transhydrogenase activity	mitochondrial inner membrane | plasma membrane	Acetylation | Cell inner membrane | Cell membrane | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | NADP | Nucleotide-binding | Transit peptide | Translocase | Transmembrane | Transmembrane helix		The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland
Rhipicephalus microplus	6941	A0A6M2CPX2	Exosome complex component 10 homolog		847	Unreviewed	Nucleus	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | histone mRNA catabolic process | nuclear polyadenylation-dependent antisense transcript catabolic process | nuclear polyadenylation-dependent CUT catabolic process | nuclear polyadenylation-dependent rRNA catabolic process | nuclear polyadenylation-dependent snoRNA catabolic process | nuclear polyadenylation-dependent snRNA catabolic process | poly(A)-dependent snoRNA 3'-end processing | TRAMP-dependent tRNA surveillance pathway	3'-5'-RNA exonuclease activity | nucleotide binding | single-stranded RNA binding	nuclear exosome (RNase complex) | nucleolus	Exonuclease | Exosome | Hydrolase | Nuclease | Nucleus | rRNA processing		
Rhipicephalus microplus	6941	A0A6M2CPV6	thioredoxin-dependent peroxiredoxin		233	Unreviewed		cell redox homeostasis | cellular response to stress | hydrogen peroxide catabolic process | response to oxidative stress	thioredoxin peroxidase activity	cytosol | mitochondrion	Antioxidant | Disulfide bond | Oxidoreductase | Peroxidase | Redox-active center		Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively
Rhipicephalus microplus	6941	A0A6M2CPR5	DNA polymerase		326	Unreviewed	Cytoplasm | Nucleus	base-excision repair | double-strand break repair via nonhomologous end joining	class I DNA-(apurinic or apyrimidinic site) endonuclease activity | DNA binding | DNA-directed DNA polymerase activity | metal ion binding	cytoplasm | nucleus	Cytoplasm | DNA damage | DNA repair | DNA replication | DNA synthesis | DNA-binding | DNA-directed DNA polymerase | Lyase | Magnesium | Metal-binding | Methylation | Nucleotidyltransferase | Nucleus | Sodium | Transferase | Ubl conjugation		DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity
Rhipicephalus microplus	6941	A0A6M2CPP9	Eukaryotic translation initiation factor 3 subunit A		1101	Unreviewed	Cytoplasm	formation of cytoplasmic translation initiation complex | translation reinitiation	mRNA binding | translation initiation factor activity	eukaryotic 43S preinitiation complex | eukaryotic 48S preinitiation complex | eukaryotic translation initiation factor 3 complex, eIF3e | eukaryotic translation initiation factor 3 complex, eIF3m | multi-eIF complex	Coiled coil | Cytoplasm | Initiation factor | Protein biosynthesis | RNA-binding		RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation
Rhipicephalus microplus	6941	A0A6M2CMU0	(3R)-3-hydroxyacyl-CoA dehydrogenase		252	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6M2CPL1	[heparan sulfate]-glucosamine N-sulfotransferase		415	Unreviewed	Golgi apparatus membrane	heparan sulfate proteoglycan biosynthetic process | heparin proteoglycan biosynthetic process	deacetylase activity | heparan sulfate N-sulfotransferase activity | hydrolase activity	Golgi membrane	Disulfide bond | Glycoprotein | Golgi apparatus | Hydrolase | Membrane | Multifunctional enzyme | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6M2CPG6	Acyl-coenzyme A thioesterase 13		161	Unreviewed	Cytoplasm, cytoskeleton, spindle | Cytoplasm, cytosol | Mitochondrion | Nucleus	lipid metabolic process	fatty acyl-CoA hydrolase activity	cytosol | mitochondrion | nucleus | spindle	Acetylation | Cytoplasm | Cytoskeleton | Hydrolase | Lipid metabolism | Mitochondrion | Nucleus		Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis
Rhipicephalus microplus	6941	A0A6M2CPA8	(3R)-3-hydroxyacyl-CoA dehydrogenase		273	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6M2CP76	Serine/threonine-protein kinase RIO2		537	Unreviewed	Cytoplasm	maturation of SSU-rRNA	ATP binding | metal ion binding | protein serine/threonine kinase activity	cytosol | nucleus | preribosome, small subunit precursor	ATP-binding | Cytoplasm | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Ribosome biogenesis | Serine/threonine-protein kinase | Transferase		
Rhipicephalus microplus	6941	A0A6M2CP41	Sulfide:quinone oxidoreductase, mitochondrial		440	Unreviewed	Mitochondrion	sulfide oxidation, using sulfide:quinone oxidoreductase	FAD binding | glutathione-dependent sulfide quinone oxidoreductase activity | quinone binding | sulfide:quinone oxidoreductase activity	mitochondrion	FAD | Flavoprotein | Mitochondrion | Oxidoreductase | Quinone | Transit peptide		Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione
Rhipicephalus microplus	6941	A0A6M2CNZ2	Dihydrolipoyl dehydrogenase		513	Unreviewed		2-oxoglutarate metabolic process | cellular respiration	dihydrolipoyl dehydrogenase (NADH) activity | flavin adenine dinucleotide binding	mitochondrion | oxoglutarate dehydrogenase complex | pyruvate dehydrogenase complex	Disulfide bond | FAD | Flavoprotein | NAD | Nucleotide-binding | Oxidoreductase | Redox-active center		
Rhipicephalus microplus	6941	A0A6M2CNW7	2-hydroxyacyl-CoA lyase 1		574	Unreviewed	Peroxisome	fatty acid alpha-oxidation	2-hydroxyacyl-CoA lyase activity | magnesium ion binding | thiamine pyrophosphate binding	peroxisome	Fatty acid metabolism | Lipid metabolism | Lyase | Magnesium | Membrane | Metal-binding | Peroxisome | Phosphoprotein | Thiamine pyrophosphate | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6M2CNU2	Exosome complex component RRP4		287	Unreviewed	Cytoplasm | Nucleus, nucleolus	CUT catabolic process | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | nuclear polyadenylation-dependent rRNA catabolic process | poly(A)-dependent snoRNA 3'-end processing | regulation of gene expression | TRAMP-dependent tRNA surveillance pathway | U4 snRNA 3'-end processing	exonuclease activity | RNA binding	cytoplasmic exosome (RNase complex) | nuclear exosome (RNase complex) | nucleolus	Cytoplasm | Exonuclease | Exosome | Hydrolase | Nuclease | Nucleus | Phosphoprotein | RNA-binding | rRNA processing		
Rhipicephalus microplus	6941	A0A6M2CNR6	Aminopeptidase		834	Unreviewed	Cell membrane | Cytoplasm	peptide catabolic process | proteolysis	alanyl aminopeptidase activity | metalloaminopeptidase activity | peptide binding | zinc ion binding	cytoplasm | extracellular space | plasma membrane	Aminopeptidase | Cytoplasm | Hydrolase | Metal-binding | Metalloprotease | Protease | Zinc		
Rhipicephalus microplus	6941	A0A6M2CNQ5	Dihydrolipoyl dehydrogenase		513	Unreviewed		2-oxoglutarate metabolic process | cellular respiration	dihydrolipoyl dehydrogenase (NADH) activity | flavin adenine dinucleotide binding	mitochondrion | oxoglutarate dehydrogenase complex | pyruvate dehydrogenase complex	Disulfide bond | FAD | Flavoprotein | NAD | Nucleotide-binding | Oxidoreductase | Redox-active center		
Rhipicephalus microplus	6941	A0A6M2CNI3	Vesicle-associated membrane protein 7		219	Unreviewed	Cytoplasmic vesicle, phagosome membrane | Cytoplasmic vesicle, secretory vesicle membrane | Endoplasmic reticulum membrane | Golgi apparatus, trans-Golgi network membrane | Late endosome membrane | Lysosome membrane	exocytosis | protein transport | vesicle fusion	SNAP receptor activity | SNARE binding	endoplasmic reticulum membrane | Golgi apparatus | late endosome membrane | lysosomal membrane | phagocytic vesicle membrane | SNARE complex | transport vesicle membrane	Coiled coil | Membrane | Protein transport | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus microplus	6941	A0A6M2CNA5	alpha-1,2-Mannosidase		957	Unreviewed	Endoplasmic reticulum	carbohydrate metabolic process | endoplasmic reticulum mannose trimming | positive regulation of retrograde protein transport, ER to cytosol	calcium ion binding | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum quality control compartment | membrane	Calcium | Endoplasmic reticulum | Glycoprotein | Glycosidase | Hydrolase | Metal-binding | Signal		Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins
Rhipicephalus microplus	6941	A0A6M2CN54	N-terminal methionine N(alpha)-acetyltransferase NatE		175	Unreviewed	Cytoplasm	mitotic sister chromatid cohesion	protein N-terminal-methionine acetyltransferase activity	NatA complex	Acyltransferase | Cytoplasm | Transferase		
Rhipicephalus microplus	6941	A0A6M2CN42	(3R)-3-hydroxyacyl-CoA dehydrogenase		232	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6M2CPH3	Proton-coupled zinc antiporter SLC30A5		745	Unreviewed	Cytoplasmic vesicle, COPII-coated vesicle membrane | Cytoplasmic vesicle, secretory vesicle membrane | Golgi apparatus, Golgi stack membrane | Golgi apparatus, trans-Golgi network membrane	intracellular zinc ion homeostasis | zinc ion import into Golgi lumen	antiporter activity | metal ion binding | zinc ion transmembrane transporter activity	ER to Golgi transport vesicle membrane | Golgi cisterna membrane	Antiport | Golgi apparatus | Ion transport | Membrane | Metal-binding | Transmembrane | Transmembrane helix | Transport | Zinc | Zinc transport		
Rhipicephalus microplus	6941	A0A6M2CKP6	Phosphoenolpyruvate carboxykinase [GTP]		648	Unreviewed		cellular response to glucose stimulus | gluconeogenesis | glycerol biosynthetic process from pyruvate | oxaloacetate metabolic process | propionate catabolic process | response to lipid | response to starvation	GTP binding | kinase activity | manganese ion binding | phosphoenolpyruvate carboxykinase (GTP) activity	cytosol	Decarboxylase | GTP-binding | Kinase | Lyase | Manganese | Metal-binding | Nucleotide-binding | Pyruvate | Transferase		Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle
Rhipicephalus microplus	6941	A0A6M2CIX0	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial		423	Unreviewed	Mitochondrion	succinyl-CoA metabolic process | tricarboxylic acid cycle	ATP binding | GTP binding | magnesium ion binding | succinate-CoA ligase (ADP-forming) activity | succinate-CoA ligase (GDP-forming) activity	mitochondrion | succinate-CoA ligase complex	GTP-binding | Ligase | Magnesium | Metal-binding | Mitochondrion | Nucleotide-binding | Tricarboxylic acid cycle		GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
Rhipicephalus microplus	6941	A0A6M2CKJ9	Aminomethyltransferase		408	Unreviewed	Mitochondrion	glycine catabolic process | methylation	aminomethyltransferase activity | methyltransferase activity | transaminase activity	glycine cleavage complex | mitochondrion	Aminotransferase | Methyltransferase | Mitochondrion | Transferase | Transit peptide		The glycine cleavage system catalyzes the degradation of glycine
Rhipicephalus microplus	6941	A0A6M2CH87	(3R)-3-hydroxyacyl-CoA dehydrogenase		254	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6G5AC67	Sodium/potassium-transporting ATPase subunit alpha		1037	Unreviewed	Cell membrane	intracellular potassium ion homeostasis | intracellular sodium ion homeostasis | potassium ion import across plasma membrane | proton transmembrane transport | sodium ion export across plasma membrane	ATP binding | ATP hydrolysis activity | metal ion binding | P-type sodium:potassium-exchanging transporter activity	cation-transporting ATPase complex | plasma membrane protein complex	ATP-binding | Cell membrane | Ion transport | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Potassium | Potassium transport | Sodium | Sodium transport | Sodium/potassium transport | Translocase | Transmembrane | Transmembrane helix | Transport		This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients
Rhipicephalus microplus	6941	A0A6M2CH68	Glucosylceramidase		384	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Signal | Sphingolipid metabolism		
Rhipicephalus microplus	6941	A0A6M2CH34	Glycine N-methyltransferase		306	Unreviewed	Cytoplasm	methylation | one-carbon metabolic process | protein homotetramerization | regulation of gluconeogenesis | S-adenosylhomocysteine metabolic process | S-adenosylmethionine metabolic process | sarcosine metabolic process	folic acid binding | glycine binding | glycine N-methyltransferase activity | identical protein binding | S-adenosyl-L-methionine binding	cytosol	Cytoplasm | Folate-binding | Methyltransferase | Phosphoprotein | S-adenosyl-L-methionine | Transferase		
Rhipicephalus microplus	6941	A0A6M2CH29	Mitochondrial 2-oxodicarboxylate carrier		139	Unreviewed	Mitochondrion inner membrane			mitochondrial inner membrane	Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle
Rhipicephalus microplus	6941	A0A6M2CH20	(3R)-3-hydroxyacyl-CoA dehydrogenase		241	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6M2CGZ2	Glucosylceramidase		506	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Signal | Sphingolipid metabolism		
Rhipicephalus microplus	6941	A0A6M2CGY8	(3R)-3-hydroxyacyl-CoA dehydrogenase		254	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6G9KGL5	Cytochrome c oxidase subunit 1	COX1	224	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6G9KE97	Cytochrome c oxidase subunit 1	COX1	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6G7PT52	Cytochrome c oxidase subunit 1	COX1	207	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6G7PSR0	Cytochrome c oxidase subunit 1	COX1	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6G7PSP5	Cytochrome c oxidase subunit 1	COX1	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6G7PSN4	Cytochrome c oxidase subunit 1	COX1	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6G7PSK4	Cytochrome c oxidase subunit 1	COX1	208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6G7PSF8	Cytochrome c oxidase subunit 1	COX1	190	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6G5AGP2	Ubiquitin carboxyl-terminal hydrolase		276	Unreviewed		protein K48-linked deubiquitination | proteolysis	cysteine-type carboxypeptidase activity | cysteine-type deubiquitinase activity | histone deubiquitinase activity | K48-linked deubiquitinase activity | K48-linked polyubiquitin modification-dependent protein binding	cell periphery | cytosol	Hydrolase | Protease | Thiol protease | Ubl conjugation pathway		Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover
Rhipicephalus microplus	6941	A0A6G5AEP0	tRNA (guanine-N(7)-)-methyltransferase		251	Unreviewed	Nucleus		tRNA (guanine(46)-N7)-methyltransferase activity | tRNA binding	nucleus | tRNA (m7G46) methyltransferase complex	Methyltransferase | Nucleus | RNA-binding | S-adenosyl-L-methionine | Transferase | tRNA processing | tRNA-binding		Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
Rhipicephalus microplus	6941	A0A6G5AEK7	Acireductone dioxygenase		185	Unreviewed	Cell membrane | Cytoplasm | Nucleus	L-methionine salvage from methylthioadenosine	acireductone dioxygenase (Ni2+-requiring) activity | acireductone dioxygenase [iron(II)-requiring] activity | iron ion binding | nickel cation binding	cytoplasm | nucleus | plasma membrane	Amino-acid biosynthesis | Cytoplasm | Dioxygenase | Iron | Metal-binding | Methionine biosynthesis | Nickel | Nucleus | Oxidoreductase		Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Rhipicephalus microplus	6941	A0A6G5AEE2	P-type phospholipid transporter		285	Unreviewed	Endomembrane system	endocytosis | phospholipid translocation | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ATP binding | ATP hydrolysis activity | ATPase-coupled intramembrane lipid transporter activity | metal ion binding	endosome | plasma membrane | trans-Golgi network	ATP-binding | Lipid transport | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Translocase | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus microplus	6941	A0A6G5AEB9	Putative voltage-dependent p/q type calcium channel voltage-dependent p/q type calcium channel		503	Unreviewed	Membrane	calcium ion import across plasma membrane | calcium-mediated signaling | chemical synaptic transmission | detection of abiotic stimulus | detection of external stimulus | detection of stimulus involved in sensory perception | epithelial fluid transport | neuron remodeling	high voltage-gated calcium channel activity | metal ion binding	basolateral plasma membrane | synapse | voltage-gated calcium channel complex	Calcium | Calcium channel | Calcium transport | Glycoprotein | Ion channel | Ion transport | Membrane | Metal-binding | Repeat | Transmembrane | Transmembrane helix | Transport | Voltage-gated channel		
Rhipicephalus microplus	6941	A0A6G5ADP3	Calreticulin		411	Unreviewed	Endoplasmic reticulum lumen	ERAD pathway | protein folding	calcium ion binding | carbohydrate binding | unfolded protein binding	endoplasmic reticulum lumen | endoplasmic reticulum membrane	Calcium | Chaperone | Disulfide bond | Endoplasmic reticulum | Lectin | Metal-binding | Repeat | Signal | Zinc		Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER
Rhipicephalus microplus	6941	A0A6G5ADF5	N-alpha-acetyltransferase 20		173	Unreviewed	Cytoplasm | Nucleus		protein N-terminal-methionine acetyltransferase activity	NatB complex | nucleus	Acyltransferase | Cytoplasm | Nucleus | Transferase		Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration
Rhipicephalus microplus	6941	A0A6G5ADD6	U6 snRNA-associated Sm-like protein LSm6		79	Unreviewed	Cytoplasm | Nucleus	maturation of SSU-rRNA | mRNA splicing, via spliceosome | tRNA processing	RNA binding	Lsm2-8 complex | nucleolus | P-body | sno(s)RNA-containing ribonucleoprotein complex | spliceosomal complex | U4/U6 x U5 tri-snRNP complex | U6 snRNP	Cytoplasm | mRNA processing | mRNA splicing | Nucleus | Ribonucleoprotein | RNA-binding | rRNA processing | Spliceosome | tRNA processing		Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome
Rhipicephalus microplus	6941	A0A6G5ACZ5	Survival of motor neuron-related-splicing factor 30		282	Unreviewed	Nucleus speckle | Nucleus, Cajal body	mRNA processing | regulation of alternative mRNA splicing, via spliceosome | RNA splicing	RNA binding	Cajal body | cytoplasm | nuclear speck | precatalytic spliceosome	Coiled coil | mRNA processing | mRNA splicing | Nucleus | Spliceosome		Involved in spliceosome assembly
Rhipicephalus microplus	6941	A0A6G5ACU6	Serine/threonine-protein phosphatase PGAM5, mitochondrial		235	Unreviewed	Mitochondrion outer membrane	positive regulation of mitochondrial fission	protein serine/threonine phosphatase activity	mitochondrial outer membrane	Hydrolase | Membrane | Mitochondrion | Mitochondrion outer membrane		Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity
Rhipicephalus microplus	6941	A0A6M2CQK0	Pseudouridylate synthase 1 homolog		440	Unreviewed	Nucleus	mRNA processing | mRNA pseudouridine synthesis | tRNA pseudouridine synthesis	RNA binding | tRNA pseudouridine(38-40) synthase activity	nucleus	Isomerase | mRNA processing | Nucleus | tRNA processing		Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA
Rhipicephalus microplus	6941	A0A6M2CHP2	Pyridoxal kinase		324	Unreviewed		pyridoxal 5'-phosphate salvage	ATP binding | pyridoxal kinase activity	cytosol	ATP-binding | Kinase | Nucleotide-binding | Transferase		
Rhipicephalus microplus	6941	A0A6M2CHU4	Acireductone dioxygenase		185	Unreviewed	Cell membrane | Cytoplasm | Nucleus	L-methionine salvage from methylthioadenosine	acireductone dioxygenase (Ni2+-requiring) activity | acireductone dioxygenase [iron(II)-requiring] activity | iron ion binding | nickel cation binding	cytoplasm | nucleus | plasma membrane	Amino-acid biosynthesis | Cytoplasm | Dioxygenase | Iron | Metal-binding | Methionine biosynthesis | Nickel | Nucleus | Oxidoreductase		Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Rhipicephalus microplus	6941	A0A6M2CI59	ADP-ribosylhydrolase ARH3		361	Unreviewed	Chromosome | Cytoplasm | Mitochondrion matrix | Nucleus	DNA repair | peptidyl-serine ADP-deribosylation	metal ion binding | poly(ADP-ribose) glycohydrolase activity	chromosome | mitochondrial matrix | nucleus	Chromosome | Cytoplasm | DNA damage | DNA repair | Hydrolase | Magnesium | Metal-binding | Mitochondrion | Nucleus		
Rhipicephalus microplus	6941	A0A6M2CI75	(3R)-3-hydroxyacyl-CoA dehydrogenase		251	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6M2CKI3	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial		272	Unreviewed	Mitochondrion matrix	cell differentiation | fatty acid beta-oxidation | spermatogenesis	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity | NAD+ binding	mitochondrial matrix	Acetylation | Differentiation | Fatty acid metabolism | Hydroxylation | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Spermatogenesis | Transit peptide		Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes
Rhipicephalus microplus	6941	A0A6M2CKG5	DNA polymerase		479	Unreviewed	Nucleus	DNA replication | double-strand break repair via nonhomologous end joining	DNA binding | DNA-directed DNA polymerase activity | lyase activity | metal ion binding	nucleus	DNA damage | DNA repair | DNA replication | DNA synthesis | DNA-binding | DNA-directed DNA polymerase | Lyase | Metal-binding | Nucleotidyltransferase | Nucleus | Transferase		DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity
Rhipicephalus microplus	6941	A0A6M2CK93	glycine hydroxymethyltransferase		499	Unreviewed		glycine biosynthetic process from serine | methylation | tetrahydrofolate interconversion	glycine hydroxymethyltransferase activity | methyltransferase activity | pyridoxal phosphate binding	mitochondrion	Methyltransferase | One-carbon metabolism | Pyridoxal phosphate | Transferase		Interconversion of serine and glycine
Rhipicephalus microplus	6941	A0A6M2CK87	serine C-palmitoyltransferase		534	Unreviewed	Endoplasmic reticulum membrane	ceramide biosynthetic process | sphingosine biosynthetic process	pyridoxal phosphate binding | serine C-palmitoyltransferase activity	endoplasmic reticulum membrane | serine palmitoyltransferase complex	Acyltransferase | Endoplasmic reticulum | Lipid metabolism | Membrane | Pyridoxal phosphate | Sphingolipid metabolism | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6M2CK63	mitogen-activated protein kinase		370	Unreviewed		cellular response to arsenic-containing substance | cellular response to cadmium ion | cellular response to reactive oxygen species | defense response to bacterium | defense response to fungus | determination of adult lifespan | heart morphogenesis | immune response | paracrine signaling | positive regulation of cell size | regulation of adult chitin-containing cuticle pigmentation | regulation of cellular response to oxidative stress | response to heat | response to hydrogen peroxide | response to osmotic stress | response to starvation	ATP binding | MAP kinase activity		ATP-binding | Kinase | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Transferase		
Rhipicephalus microplus	6941	A0A6M2CK40	Casein kinase II subunit alpha		440	Unreviewed		regulation of cell cycle	ATP binding | protein serine/threonine kinase activity	cytosol | nucleus | protein kinase CK2 complex	ATP-binding | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase		Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling
Rhipicephalus microplus	6941	A0A6M2CJZ9	(3R)-3-hydroxyacyl-CoA dehydrogenase		254	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6M2CJS7	Putative 26 kDa family member		238	Unreviewed	Endomembrane system			endomembrane system | membrane	Membrane | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6M2CJQ6	Endonuclease III homolog	NTH1	300	Unreviewed	Nucleus | Mitochondrion	base-excision repair, AP site formation | nucleotide-excision repair	4 iron, 4 sulfur cluster binding | class I DNA-(apurinic or apyrimidinic site) endonuclease activity | DNA binding | metal ion binding | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	mitochondrion | nucleus	4Fe-4S | DNA damage | DNA repair | Endonuclease | Glycosidase | Hydrolase | Iron | Iron-sulfur | Lyase | Metal-binding | Mitochondrion | Nuclease | Nucleus | Transit peptide		Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines
Rhipicephalus microplus	6941	A0A6M2CJN8	Glucosylceramidase		471	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Signal | Sphingolipid metabolism		
Rhipicephalus microplus	6941	A0A6M2CJL2	Molybdenum cofactor biosynthesis protein 1		369	Unreviewed		Mo-molybdopterin cofactor biosynthetic process	4 iron, 4 sulfur cluster binding | cyclic pyranopterin monophosphate synthase activity | GTP 3',8'-cyclase activity | GTP binding | metal ion binding		4Fe-4S | GTP-binding | Iron | Iron-sulfur | Lyase | Metal-binding | Molybdenum cofactor biosynthesis | Nucleotide-binding | S-adenosyl-L-methionine		Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP
Rhipicephalus microplus	6941	A0A6M2CJJ4	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial		325	Unreviewed	Mitochondrion	tricarboxylic acid cycle	nucleotide binding | succinate-CoA ligase (ADP-forming) activity | succinate-CoA ligase (GDP-forming) activity	mitochondrion | succinate-CoA ligase complex (ADP-forming)	Ligase | Mitochondrion | Nucleotide-binding | Tricarboxylic acid cycle		Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits
Rhipicephalus microplus	6941	A0A6M2CJJ2	Deoxyribose-phosphate aldolase		320	Unreviewed	Cytoplasmic granule | Nucleus	carbohydrate catabolic process | deoxyribonucleotide catabolic process | deoxyribose phosphate catabolic process	deoxyribose-phosphate aldolase activity	cytoplasm | nucleus	Cytoplasm | Lyase | Nucleus | Schiff base		Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation
Rhipicephalus microplus	6941	A0A6M2CKK5	Glycerol-3-phosphate dehydrogenase [NAD(+)]		349	Unreviewed	Cytoplasm	carbohydrate metabolic process | glycerol-3-phosphate catabolic process | glycerophospholipid metabolic process	glycerol-3-phosphate dehydrogenase (NAD+) activity | NAD binding | protein homodimerization activity	cytosol	Cytoplasm | NAD | Oxidoreductase		
Rhipicephalus microplus	6941	A0A6M2CJE4	Cytidine deaminase		135	Unreviewed		nucleobase-containing small molecule metabolic process | pyrimidine-containing compound metabolic process	cytidine deaminase activity | identical protein binding | zinc ion binding	cytosol	Hydrolase | Metal-binding | Zinc		This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
Rhipicephalus microplus	6941	A0A6M2CJ95	Phosphomannomutase		253	Unreviewed	Cytoplasm	GDP-mannose biosynthetic process | mannose metabolic process | protein N-linked glycosylation	metal ion binding | phosphomannomutase activity	cytosol	Cytoplasm | Isomerase | Magnesium | Metal-binding		Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions
Rhipicephalus microplus	6941	A0A6M2CJ87	Dolichol-phosphate mannosyltransferase subunit 1		229	Unreviewed	Endoplasmic reticulum	dolichol-linked oligosaccharide biosynthetic process | GPI anchor biosynthetic process | protein O-linked glycosylation via mannose	dolichyl-phosphate beta-D-mannosyltransferase activity | metal ion binding	endoplasmic reticulum membrane	Endoplasmic reticulum | Glycosyltransferase | Magnesium | Manganese | Metal-binding | Transferase		Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins
Rhipicephalus microplus	6941	A0A6M2CJ28	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase		352	Unreviewed		proteolysis	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity | peptidase activity	lysosome	Autocatalytic cleavage | Hydrolase | Protease | Signal		Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins
Rhipicephalus microplus	6941	A0A6M2CJ24	Bifunctional purine biosynthesis protein ATIC		593	Unreviewed	Cytoplasm, cytosol	'de novo' IMP biosynthetic process	IMP cyclohydrolase activity | phosphoribosylaminoimidazolecarboxamide formyltransferase activity	cytosol	Cytoplasm | Hydrolase | Multifunctional enzyme | Purine biosynthesis | Transferase		
Rhipicephalus microplus	6941	A0A6M2CJ08	Glucosamine-6-phosphate isomerase		283	Unreviewed	Cytoplasm	carbohydrate metabolic process | glucosamine catabolic process | N-acetylglucosamine catabolic process | N-acetylneuraminate catabolic process	glucosamine-6-phosphate deaminase activity | identical protein binding | isomerase activity	cytoplasm	Carbohydrate metabolism | Cytoplasm | Hydrolase | Isomerase		Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway
Rhipicephalus microplus	6941	A0A6M2CIY7	Ribokinase		337	Unreviewed	Cytoplasm | Nucleus	D-ribose catabolic process	ATP binding | metal ion binding | ribokinase activity	cytosol | nucleus	ATP-binding | Carbohydrate metabolism | Cytoplasm | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Nucleus | Potassium | Transferase		Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Rhipicephalus microplus	6941	A0A6M2CIX7	Isocitrate dehydrogenase [NADP]		411	Unreviewed		glyoxylate cycle | isocitrate metabolic process | NADP+ metabolic process | tricarboxylic acid cycle	isocitrate dehydrogenase (NADP+) activity | magnesium ion binding | NAD binding	cytosol | mitochondrion | peroxisome	Glyoxylate bypass | Magnesium | Manganese | Metal-binding | NADP | Oxidoreductase | Reference proteome | Tricarboxylic acid cycle		
Rhipicephalus microplus	6941	A0A6M2CIV0	Ribose-phosphate pyrophosphokinase 2		318	Unreviewed		5-phosphoribose 1-diphosphate biosynthetic process | purine nucleotide biosynthetic process | ribonucleoside monophosphate biosynthetic process	ATP binding | kinase activity | magnesium ion binding | ribose phosphate diphosphokinase activity	cytoplasm | ribose phosphate diphosphokinase complex	ATP-binding | Kinase | Magnesium | Metal-binding | Nucleotide biosynthesis | Nucleotide-binding | Transferase		Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis
Rhipicephalus microplus	6941	A0A6M2CIS4	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase		246	Unreviewed		proteolysis	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity | peptidase activity	lysosome	Autocatalytic cleavage | Hydrolase | Protease		Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins
Rhipicephalus microplus	6941	A0A6M2CIR8	RING-type E3 ubiquitin transferase		717	Unreviewed	Target cell membrane	exocytosis | protein ubiquitination	ligase activity | ubiquitin protein ligase activity | zinc ion binding	cytoplasm | host cell presynaptic membrane | other organism cell membrane	ANK repeat | Exocytosis | Ligase | Membrane | Metal-binding | Neurotoxin | Presynaptic neurotoxin | Repeat | Target cell membrane | Target membrane | Toxin | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		
Rhipicephalus microplus	6941	A0A6M2CIF7	(3R)-3-hydroxyacyl-CoA dehydrogenase		218	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6M2CIF5	(3R)-3-hydroxyacyl-CoA dehydrogenase		248	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6M2D228	Putative molybdopterin biosynthesis protein		521	Unreviewed		establishment of synaptic specificity at neuromuscular junction | gamma-aminobutyric acid receptor clustering | glycine receptor clustering | Mo-molybdopterin cofactor biosynthetic process | postsynaptic neurotransmitter receptor diffusion trapping	ATP binding | metal ion binding | molybdopterin adenylyltransferase activity | molybdopterin molybdotransferase activity	cytosol | dendrite | postsynaptic specialization membrane	ATP-binding | Magnesium | Metal-binding | Molybdenum | Molybdenum cofactor biosynthesis | Multifunctional enzyme | Nucleotide-binding | Transferase		Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released
Rhipicephalus microplus	6941	A0A6M2CJ97	Trifunctional purine biosynthetic protein adenosine-3		919	Unreviewed		'de novo' IMP biosynthetic process | adenine biosynthetic process	ATP binding | metal ion binding | phosphoribosylamine-glycine ligase activity | phosphoribosylformylglycinamidine cyclo-ligase activity | phosphoribosylglycinamide formyltransferase activity	cytosol	ATP-binding | Ligase | Manganese | Metal-binding | Multifunctional enzyme | Nucleotide-binding | Purine biosynthesis | Transferase		
Rhipicephalus microplus	6941	A0A6M2CQN1	tetrahydrofolate synthase		559	Unreviewed	Cytoplasm | Mitochondrion inner membrane | Mitochondrion matrix	one-carbon metabolic process	ATP binding | metal ion binding | tetrahydrofolylpolyglutamate synthase activity	cytosol | mitochondrial inner membrane | mitochondrial matrix	ATP-binding | Cytoplasm | Ligase | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Nucleotide-binding | One-carbon metabolism		
Rhipicephalus microplus	6941	A0A6M2CZ49	Histone acetyltransferase type B catalytic subunit		421	Unreviewed	Nucleus	DNA repair | subtelomeric heterochromatin formation	histone acetyltransferase activity | histone binding	chromosome, telomeric region | nucleus	Acyltransferase | Coiled coil | DNA damage | DNA repair | Nucleus | Transferase		
Rhipicephalus microplus	6941	A0A6M2CQX1	Ubiquitin carboxyl-terminal hydrolase		385	Unreviewed		protein K48-linked deubiquitination | proteolysis	cysteine-type carboxypeptidase activity | cysteine-type deubiquitinase activity | histone deubiquitinase activity | K48-linked deubiquitinase activity | K48-linked polyubiquitin modification-dependent protein binding	cell periphery | cytosol	Hydrolase | Protease | Thiol protease | Ubl conjugation pathway		Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover
Rhipicephalus microplus	6941	A0A6M2CYH4	M-phase inducer phosphatase		507	Unreviewed		cell division | developmental process | endomembrane system organization | G2/M transition of mitotic cell cycle | positive regulation of G2/M transition of mitotic cell cycle | positive regulation of G2/MI transition of meiotic cell cycle | regulation of mitotic cell cycle, embryonic	protein tyrosine phosphatase activity	cytoplasm | nucleus	Cell cycle | Cell division | Hydrolase | Mitosis | Protein phosphatase		Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression
Rhipicephalus microplus	6941	A0A6M2CYE4	SNF-related serine/threonine-protein kinase		719	Unreviewed	Nucleus	intracellular signal transduction	ATP binding | metal ion binding | protein serine/threonine kinase activity	cytoplasm | nucleus	ATP-binding | Kinase | Magnesium | Metal-binding | Methylation | Nucleotide-binding | Nucleus | Phosphoprotein | Serine/threonine-protein kinase | Transferase		May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis
Rhipicephalus microplus	6941	A0A6M2CYC2	Elongator complex protein 3		550	Unreviewed		tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	4 iron, 4 sulfur cluster binding | metal ion binding | tRNA binding | tRNA uridine(34) acetyltransferase activity	cytoplasm | elongator holoenzyme complex | nucleus	4Fe-4S | Acyltransferase | Iron | Iron-sulfur | Metal-binding | RNA-binding | S-adenosyl-L-methionine | Transferase | tRNA processing | tRNA-binding		Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs
Rhipicephalus microplus	6941	A0A6M2CY88	NAD-dependent protein deacylase		296	Unreviewed	Mitochondrion		histone deacetylase activity, NAD-dependent | NAD+ binding | protein-malonyllysine demalonylase activity | protein-succinyllysine desuccinylase activity | zinc ion binding	mitochondrion | nucleus	Metal-binding | Mitochondrion | NAD | Transferase | Zinc		NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo
Rhipicephalus microplus	6941	A0A6M2CY71	DNA replication licensing factor MCM7	MCM7	714	Unreviewed	Chromosome | Nucleus	DNA replication initiation | DNA strand elongation involved in DNA replication | double-strand break repair via break-induced replication	ATP binding | hydrolase activity | single-stranded DNA binding | single-stranded DNA helicase activity	chromosome | MCM complex | nucleus	ATP-binding | Cell cycle | Chromosome | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Ubl conjugation		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Rhipicephalus microplus	6941	A0A6M2CY43	Sialin		543	Unreviewed	Basolateral cell membrane | Cytoplasmic vesicle, secretory vesicle membrane | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane | Lysosome membrane	carboxylic acid transport | monoatomic anion transport	symporter activity	basolateral plasma membrane | lysosomal membrane | synaptic vesicle membrane	Cell membrane | Cytoplasmic vesicle | Glycoprotein | Lysosome | Membrane | Symport | Synapse | Transmembrane | Transmembrane helix | Transport		Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties
Rhipicephalus microplus	6941	A0A6M2CY38	DNA topoisomerase		711	Unreviewed	Mitochondrion matrix	DNA recombination | DNA repair | DNA topological change	DNA binding | DNA topoisomerase type I (single strand cut, ATP-independent) activity | zinc ion binding	mitochondrial matrix | nucleoplasm | RecQ family helicase-topoisomerase III complex	DNA-binding | Isomerase | Magnesium | Metal-binding | Mitochondrion | Repeat | Topoisomerase | Zinc | Zinc-finger		Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand
Rhipicephalus microplus	6941	A0A6M2CXZ1	Putative serine/threonine kinase ovary overexpressed		345	Unreviewed	Nucleus	cell division | G2/M transition of mitotic cell cycle | mitotic G2 DNA damage checkpoint signaling | positive regulation of cell cycle process | positive regulation of meiotic cell cycle	ATP binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	nucleus	ATP-binding | Cell cycle | Cell division | Kinase | Mitosis | Nucleotide-binding | Nucleus | Phosphoprotein | Serine/threonine-protein kinase | Transferase		Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia
Rhipicephalus microplus	6941	A0A6M2CXX8	Homogentisate 1,2-dioxygenase		471	Unreviewed		L-phenylalanine catabolic process | L-tyrosine catabolic process	homogentisate 1,2-dioxygenase activity | metal ion binding	cytoplasm	Dioxygenase | Iron | Metal-binding | Oxidoreductase | Phenylalanine catabolism | Tyrosine catabolism		
Rhipicephalus microplus	6941	A0A6M2CXV5	Elongin-B		118	Unreviewed	Nucleus	transcription elongation by RNA polymerase II	translation elongation factor activity	elongin complex | VCB complex	Acetylation | Elongation factor | Nucleus | Phosphoprotein | Protein biosynthesis | Reference proteome | Transcription | Transcription regulation | Ubl conjugation pathway		SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells
Rhipicephalus microplus	6941	A0A6M2CXU5	succinate dehydrogenase		641	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, succinate to ubiquinone | tricarboxylic acid cycle	electron transfer activity | flavin adenine dinucleotide binding | succinate dehydrogenase (quinone) activity	mitochondrial inner membrane	Electron transport | FAD | Flavoprotein | Membrane | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Transit peptide | Transport | Tricarboxylic acid cycle | Ubiquinone		
Rhipicephalus microplus	6941	A0A6M2CXT8	Aspartate aminotransferase		407	Unreviewed	Cytoplasm	aspartate biosynthetic process	L-aspartate:2-oxoglutarate aminotransferase activity | L-cysteine transaminase activity | pyridoxal phosphate binding	cytosol	Aminotransferase | Cytoplasm | Pyridoxal phosphate | Transferase		
Rhipicephalus microplus	6941	A0A6M2CXQ0	thioredoxin-disulfide reductase (NADPH)		472	Unreviewed		cell redox homeostasis | cellular response to oxidative stress | glutathione metabolic process	flavin adenine dinucleotide binding | glutathione-disulfide reductase (NADPH) activity | thioredoxin-disulfide reductase (NADPH) activity	cytosol | mitochondrion	Disulfide bond | FAD | Flavoprotein | NAD | NADP | Nucleotide-binding | Oxidoreductase | Redox-active center | Selenocysteine		Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms
Rhipicephalus microplus	6941	A0A6M2CXP8	Neuropathy target esterase sws		759	Unreviewed	Endoplasmic reticulum membrane	lipid catabolic process | phosphatidylcholine metabolic process	phosphatidylcholine lysophospholipase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | Hydrolase | Lipid degradation | Lipid metabolism | Membrane | Phosphoprotein | Transmembrane | Transmembrane helix		Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain
Rhipicephalus microplus	6941	A0A6M2CXK2	CTP synthase		612	Unreviewed		'de novo' CTP biosynthetic process | pyrimidine nucleobase biosynthetic process	ATP binding | CTP synthase activity | identical protein binding | lyase activity	cytoophidium | cytoplasm	ATP-binding | Glutamine amidotransferase | Ligase | Lyase | Nucleotide-binding | Pyrimidine biosynthesis		Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen
Rhipicephalus microplus	6941	A0A6M2CXK0	Translin		232	Unreviewed	Cytoplasm | Nucleus	RNA metabolic process	endonuclease activity | hydrolase activity | metal ion binding | RNA binding | sequence-specific DNA binding | single-stranded DNA binding	cytoplasm | nucleus	Cytoplasm | DNA-binding | Endonuclease | Hydrolase | Magnesium | Metal-binding | Nuclease | Nucleus | RNA-binding		DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots
Rhipicephalus microplus	6941	A0A6M2CXG4	DNA replication licensing factor MCM3		818	Unreviewed	Chromosome | Nucleus	DNA strand elongation involved in DNA replication | double-strand break repair via break-induced replication | mitotic DNA replication initiation	ATP binding | hydrolase activity | single-stranded DNA binding | single-stranded DNA helicase activity	chromosome | MCM complex | nucleus	ATP-binding | Cell cycle | Chromosome | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Rhipicephalus microplus	6941	A0A6M2CXB0	Dual specificity protein phosphatase		194	Unreviewed		negative regulation of MAPK cascade	MAP kinase phosphatase activity | protein serine/threonine phosphatase activity | protein tyrosine phosphatase activity | protein tyrosine/serine/threonine phosphatase activity	cytoplasm	Hydrolase | Protein phosphatase		Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate
Rhipicephalus microplus	6941	A0A6M2CX92	DNA replication licensing factor MCM5		548	Unreviewed	Nucleus	DNA replication initiation | double-strand break repair via break-induced replication	3'-5' DNA helicase activity | ATP binding | DNA replication origin binding | hydrolase activity | single-stranded DNA binding | single-stranded DNA helicase activity	MCM complex | nucleus	ATP-binding | Cell cycle | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Rhipicephalus microplus	6941	A0A6M2CX80	Angiotensin-converting enzyme		488	Unreviewed		proteolysis	carboxypeptidase activity | metal ion binding | metallopeptidase activity | peptidyl-dipeptidase activity	plasma membrane	Carboxypeptidase | Disulfide bond | Glycoprotein | Hydrolase | Metal-binding | Metalloprotease | Protease | Signal | Zinc		
Rhipicephalus microplus	6941	A0A6M2CX40	Serine/threonine-protein phosphatase PGAM5, mitochondrial		276	Unreviewed	Mitochondrion outer membrane	positive regulation of mitochondrial fission	protein serine/threonine phosphatase activity	mitochondrial outer membrane	Hydrolase | Membrane | Mitochondrion | Mitochondrion outer membrane		Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity
Rhipicephalus microplus	6941	A0A6M2CX25	RING-type E3 ubiquitin-protein ligase PPIL2		519	Unreviewed	Nucleus	mRNA processing | protein folding | protein polyubiquitination | RNA splicing	peptidyl-prolyl cis-trans isomerase activity | ubiquitin protein ligase activity	catalytic step 2 spliceosome	Acetylation | Coiled coil | Isomerase | Isopeptide bond | mRNA processing | mRNA splicing | Nucleus | Spliceosome | Transferase | Ubl conjugation | Ubl conjugation pathway		Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs
Rhipicephalus microplus	6941	A0A6M2CWY3	(3R)-3-hydroxyacyl-CoA dehydrogenase		253	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6M2CWV9	diacylglycerol cholinephosphotransferase		416	Unreviewed	Membrane	phosphatidylethanolamine biosynthetic process	diacylglycerol cholinephosphotransferase activity | ethanolaminephosphotransferase activity	endoplasmic reticulum membrane | Golgi apparatus	Lipid biosynthesis | Lipid metabolism | Membrane | Phospholipid biosynthesis | Phospholipid metabolism | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6M2CWU9	Uracil-DNA glycosylase		297	Unreviewed	Mitochondrion | Nucleus	base-excision repair, AP site formation via deaminated base removal	uracil DNA N-glycosylase activity	mitochondrion | nucleoplasm	Acetylation | DNA damage | DNA repair | Hydrolase | Mitochondrion | Nucleus | Phosphoprotein		Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Rhipicephalus microplus	6941	A0A6M2CWM4	Polyprenal reductase		169	Unreviewed	Endomembrane system | Endoplasmic reticulum membrane	dolichol-linked oligosaccharide biosynthetic process | polyprenol catabolic process	3-oxo-5-alpha-steroid 4-dehydrogenase activity | polyprenal reductase activity | polyprenol reductase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | Membrane | NADP | Oxidoreductase | Transmembrane | Transmembrane helix		Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation
Rhipicephalus microplus	6941	A0A6M2CWM2	DNA topoisomerase I		961	Unreviewed		chromosome segregation | DNA replication | DNA topological change	DNA binding | DNA topoisomerase type I (single strand cut, ATP-independent) activity	chromosome | nucleolus	Coiled coil | DNA-binding | Isomerase | Topoisomerase		Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Rhipicephalus microplus	6941	A0A6M2CYJ8	Choline/ethanolamine transporter FLVCR1		437	Unreviewed	Cell membrane	erythrocyte maturation | heme biosynthetic process | heme export	heme binding | heme transmembrane transporter activity	mitochondrial membrane | plasma membrane	Cell membrane | Erythrocyte maturation | Glycoprotein | Membrane | Phosphoprotein | Receptor | Transmembrane | Transmembrane helix | Transport		Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis. Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids. Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane. Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment
Rhipicephalus microplus	6941	A0A6M2CYN7	Putative phosphatidylinositol-binding clathrin assembly protein		581	Unreviewed	Cytoplasmic vesicle, clathrin-coated vesicle | Golgi apparatus | Membrane, clathrin-coated pit	clathrin coat assembly | clathrin-dependent endocytosis | locomotion | synaptic vesicle budding from presynaptic endocytic zone membrane	1-phosphatidylinositol binding | clathrin heavy chain binding | phosphatidylinositol-4,5-bisphosphate binding | SNARE binding	clathrin-coated pit | clathrin-coated vesicle | extrinsic component of presynaptic endocytic zone membrane | Golgi apparatus | synaptic vesicle	Coated pit | Cytoplasmic vesicle | Endocytosis | Golgi apparatus | Membrane		
Rhipicephalus microplus	6941	A0A6M2CYR4	Tryptophan 2,3-dioxygenase		391	Unreviewed		L-tryptophan catabolic process to acetyl-CoA | L-tryptophan catabolic process to kynurenine	heme binding | L-tryptophan 2,3-dioxygenase activity | metal ion binding		Dioxygenase | Heme | Iron | Metal-binding | Oxidoreductase | Tryptophan catabolism		Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety
Rhipicephalus microplus	6941	A0A6M2CYR7	Elongation of very long chain fatty acids protein		166	Unreviewed	Membrane	fatty acid elongation, monounsaturated fatty acid | fatty acid elongation, polyunsaturated fatty acid | fatty acid elongation, saturated fatty acid | sphingolipid biosynthetic process | very long-chain fatty acid biosynthetic process	fatty acid elongase activity	endoplasmic reticulum membrane	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Membrane | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6G5AC02	Phospholipid-transporting ATPase		802	Unreviewed	Membrane	endocytosis | phospholipid translocation | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ATP binding | ATP hydrolysis activity | ATPase-coupled intramembrane lipid transporter activity | magnesium ion binding	endosome | plasma membrane | trans-Golgi network	ATP-binding | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Translocase | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6M2D227	Putative 5'-3' exonuclease hke1/rat1		390	Unreviewed	Cell projection, neuron projection | Cytoplasm, Stress granule | Perikaryon | Synapse	animal organ development | mRNA transport | nervous system development | positive regulation of long-term neuronal synaptic plasticity | positive regulation of translation | regulation of mRNA stability | regulation of translation at presynapse, modulating synaptic transmission	exonuclease activity | mRNA 3'-UTR binding | translation regulator activity	cytoplasmic stress granule | neuron projection | nucleus | perikaryon | presynapse | ribonucleoprotein complex	Cell projection | Cytoplasm | Exonuclease | Hydrolase | Neurogenesis | Nuclease | Repeat | Repressor | Ribonucleoprotein | RNA-binding | Synapse | Translation regulation		
Rhipicephalus microplus	6941	A0A6M2D1X3	Exonuclease 1		479	Unreviewed	Nucleus	DNA recombination | immune system process | meiotic cell cycle | mismatch repair	5'-3' DNA exonuclease activity | 5'-flap endonuclease activity | DNA binding | metal ion binding	nucleus	Acetylation | DNA damage | DNA excision | DNA repair | DNA-binding | Endonuclease | Excision nuclease | Exonuclease | Hydrolase | Immunity | Magnesium | Meiosis | Metal-binding | Nuclease | Nucleus | Phosphoprotein		5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis
Rhipicephalus microplus	6941	A0A6M2D1V2	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase		457	Unreviewed	Golgi apparatus membrane	protein O-linked glycosylation via N-acetyl-galactosamine	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity | carbohydrate binding | manganese ion binding	Golgi membrane	Disulfide bond | Glycosyltransferase | Golgi apparatus | Lectin | Manganese | Membrane | Metal-binding | Phosphoprotein | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans
Rhipicephalus microplus	6941	A0A6M2D1U4	ATP-dependent DNA helicase		640	Unreviewed	Nucleus	double-strand break repair via homologous recombination	3'-5' DNA helicase activity | ATP binding | DNA binding | four-way junction helicase activity | hydrolase activity | metal ion binding	chromosome | cytoplasm | nucleus	ATP-binding | Coiled coil | DNA-binding | Helicase | Hydrolase | Isomerase | Metal-binding | Nucleotide-binding | Nucleus		
Rhipicephalus microplus	6941	A0A6M2D1R5	cyclin-dependent kinase		287	Unreviewed		G1/S transition of mitotic cell cycle | positive regulation of cell cycle process | positive regulation of meiotic cell cycle | regulation of G2/M transition of mitotic cell cycle | regulation of gene expression | signal transduction	ATP binding | cyclin binding | cyclin-dependent protein serine/threonine kinase activity	cyclin-dependent protein kinase holoenzyme complex | cytoplasm | nucleus	ATP-binding | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase		
Rhipicephalus microplus	6941	A0A6M2D1R2	Ras-related protein Rab-30		217	Unreviewed	Cytoplasmic vesicle, autophagosome membrane | Golgi apparatus, cis-Golgi network | Golgi apparatus, trans-Golgi network membrane | Lysosome | Membrane		G protein activity | GTP binding | metal ion binding	autophagosome membrane | cytoplasmic vesicle | Golgi apparatus | lysosome	Cytoplasm | Cytoplasmic vesicle | Golgi apparatus | GTP-binding | Hydrolase | Lipoprotein | Lysosome | Magnesium | Membrane | Metal-binding | Methylation | Nucleotide-binding | Prenylation		The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins. Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner. Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection
Rhipicephalus microplus	6941	A0A6M2D1K3	limulus clotting factor C		985	Unreviewed	Cell surface | Secreted	cell adhesion | complement activation | hemolymph coagulation | proteolysis	carbohydrate binding | serine-type endopeptidase activity	cell surface | extracellular region | protein-containing complex	Cell adhesion | Disulfide bond | EGF-like domain | Glycoprotein | Hemolymph clotting | Hydrolase | Immunity | Innate immunity | Lectin | Protease | Repeat | Secreted | Serine protease | Signal | Sushi		
Rhipicephalus microplus	6941	A0A6M2D140	DNA-(apurinic or apyrimidinic site) endonuclease		505	Unreviewed		base-excision repair	DNA binding | DNA-(apurinic or apyrimidinic site) endonuclease activity | double-stranded DNA 3'-5' DNA exonuclease activity | phosphoric diester hydrolase activity | zinc ion binding	nucleus	DNA damage | DNA repair | Endonuclease | Hydrolase | Magnesium | Manganese | Metal-binding | Nuclease | Nucleus | Zinc | Zinc-finger		
Rhipicephalus microplus	6941	A0A6M2D125	UMP-CMP kinase		199	Unreviewed	Cytoplasm | Nucleus	'de novo' pyrimidine nucleobase biosynthetic process | pyrimidine nucleotide biosynthetic process	ATP binding | nucleoside monophosphate kinase activity	cytoplasm | nucleus	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Nucleus | Pyrimidine biosynthesis | Transferase		Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors
Rhipicephalus microplus	6941	A0A6M2D0X9	Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1		165	Unreviewed	Membrane	phospholipid biosynthetic process	phosphatidylglycerophosphatase activity | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | phosphoprotein phosphatase activity	cytoplasm | membrane	Hydrolase | Lipid biosynthesis | Lipid metabolism | Membrane | Phospholipid biosynthesis | Phospholipid metabolism | Protein phosphatase		
Rhipicephalus microplus	6941	A0A6M2D0U7	Serine/threonine-protein kinase RIO1		403	Unreviewed	Cytoplasm	ribosome biogenesis	ATP binding | hydrolase activity | metal ion binding | protein serine/threonine kinase activity	cytoplasm	ATP-binding | Cytoplasm | Hydrolase | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Ribosome biogenesis | Serine/threonine-protein kinase | Transferase		Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation
Rhipicephalus microplus	6941	A0A6M2D0Q7	Pyridoxal kinase		302	Unreviewed		pyridoxal 5'-phosphate salvage	ATP binding | pyridoxal kinase activity	cytosol	ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Transferase		
Rhipicephalus microplus	6941	A0A6M2CWJ0	Vesicle transport through interaction with t-SNAREs homolog 1A		217	Unreviewed	Endomembrane system | Golgi apparatus membrane	Golgi to vacuole transport | intra-Golgi vesicle-mediated transport | intracellular protein transport | macroautophagy | retrograde transport, endosome to Golgi | vesicle fusion with Golgi apparatus	SNAP receptor activity | SNARE binding	cytosol | endoplasmic reticulum membrane | ER to Golgi transport vesicle membrane | Golgi membrane | late endosome membrane | SNARE complex	Coiled coil | Golgi apparatus | Membrane | Protein transport | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus microplus	6941	A0A6M2D0Q4	Sugar phosphate phosphatase		403	Unreviewed		DNA damage response | methylation	metal ion binding | phosphatase activity | protein carboxyl O-methyltransferase activity	nucleus	Hydrolase | Manganese | Metal-binding | Methyltransferase | Nickel | S-adenosyl-L-methionine | Transferase		Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response
Rhipicephalus microplus	6941	A0A6M2D0D8	Kynureninase		469	Unreviewed	Cytoplasm	'de novo' NAD+ biosynthetic process from L-tryptophan | anthranilate metabolic process | L-kynurenine catabolic process | L-tryptophan catabolic process to kynurenine | quinolinate biosynthetic process	kynureninase activity | pyridoxal phosphate binding	cytoplasm	Cytoplasm | Hydrolase | Pyridine nucleotide biosynthesis | Pyridoxal phosphate		Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively
Rhipicephalus microplus	6941	A0A6M2D0D5	ADP/ATP translocase		299	Unreviewed	Membrane | Mitochondrion inner membrane	mitochondrial ADP transmembrane transport | mitochondrial ATP transmembrane transport | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ATP:ADP antiporter activity	mitochondrial inner membrane	Antiport | Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane
Rhipicephalus microplus	6941	A0A6M2D0C9	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase		1283	Unreviewed	Cytoplasm, cytosol	inositol metabolic process | inositol phosphate biosynthetic process	5-diphosphoinositol pentakisphosphate 1-kinase activity | ATP binding | inositol hexakisphosphate kinase activity | phosphatase activity	cytosol	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Transferase		Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4
Rhipicephalus microplus	6941	A0A6M2D096	SUMO-activating enzyme subunit		621	Unreviewed	Nucleus	protein sumoylation	ATP binding | metal ion binding | SUMO activating enzyme activity | transferase activity	cytoplasm | SUMO activating enzyme complex	ATP-binding | Metal-binding | Nucleotide-binding | Nucleus | Transferase | Ubl conjugation pathway | Zinc		
Rhipicephalus microplus	6941	A0A6M2D086	ATPase ASNA1 homolog		340	Unreviewed	Cytoplasm | Endoplasmic reticulum	tail-anchored membrane protein insertion into ER membrane	ATP binding | ATP hydrolysis activity | metal ion binding	GET complex	ATP-binding | Cytoplasm | Endoplasmic reticulum | Hydrolase | Metal-binding | Nucleotide-binding | Transport | Zinc		ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting
Rhipicephalus microplus	6941	A0A6M2D080	DnaJ homolog subfamily A member 1		400	Unreviewed	Cytoplasm, perinuclear region | Membrane | Microsome | Mitochondrion | Nucleus	protein folding | response to heat	ATP binding | Hsp70 protein binding | unfolded protein binding | zinc ion binding	membrane | mitochondrion | nucleus | perinuclear region of cytoplasm	Acetylation | Cytoplasm | Endoplasmic reticulum | Lipoprotein | Membrane | Metal-binding | Methylation | Microsome | Mitochondrion | Nucleus | Phosphoprotein | Reference proteome | Repeat | Zinc | Zinc-finger		
Rhipicephalus microplus	6941	A0A6M2D010	Exosome complex exonuclease RRP44		953	Unreviewed	Cytoplasm | Nucleus, nucleolus | Nucleus, nucleoplasm	CUT catabolic process | nuclear mRNA surveillance of mRNA 3'-end processing | rRNA catabolic process | rRNA processing	3'-5'-RNA exonuclease activity | endonuclease activity | RNA binding	cytoplasmic exosome (RNase complex) | nuclear exosome (RNase complex) | nucleolus | nucleoplasm	Acetylation | Cytoplasm | Endonuclease | Exonuclease | Exosome | Hydrolase | Magnesium | Manganese | Nuclease | Nucleus | Phosphoprotein | RNA-binding | rRNA processing		
Rhipicephalus microplus	6941	A0A6M2CZZ8	Dual serine/threonine and tyrosine protein kinase		551	Unreviewed	Cytoplasm	cellular response to fibroblast growth factor stimulus | negative regulation of apoptotic process | positive regulation of ERK1 and ERK2 cascade | positive regulation of fibroblast growth factor receptor signaling pathway	ATP binding | protein serine/threonine kinase activity | protein serine/threonine/tyrosine kinase activity | protein tyrosine kinase activity	cytoplasm	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase | Tyrosine-protein kinase		
Rhipicephalus microplus	6941	A0A6M2CZG7	Protein adenylyltransferase Fic		487	Unreviewed	Membrane		AMPylase activity | ATP binding	membrane	ATP-binding | Membrane | Nucleotide-binding | Nucleotidyltransferase | Repeat | TPR repeat | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6M2CZF0	Serine/threonine-protein kinase CHK1		479	Unreviewed	Chromosome | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Nucleus	DNA damage checkpoint signaling | mitotic DNA replication checkpoint signaling	ATP binding | protein serine/threonine kinase activity	centrosome | chromosome | cytoplasm | nucleus	ATP-binding | Cell cycle | Chromosome | Cytoplasm | Cytoskeleton | DNA damage | Kinase | Nucleotide-binding | Nucleus | Phosphoprotein | Serine/threonine-protein kinase | Transferase		
Rhipicephalus microplus	6941	A0A6M2CZ11	3-oxoacyl-[acyl-carrier-protein] synthase		454	Unreviewed		fatty acid biosynthetic process	3-oxoacyl-[acyl-carrier-protein] synthase activity	mitochondrion	Acyltransferase | Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Transferase		May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function
Rhipicephalus microplus	6941	A0A6M2CZ06	phosphatidate cytidylyltransferase		347	Unreviewed	Membrane	CDP-diacylglycerol biosynthetic process	phosphatidate cytidylyltransferase activity	endoplasmic reticulum membrane	Lipid biosynthesis | Lipid metabolism | Membrane | Nucleotidyltransferase | Phospholipid biosynthesis | Phospholipid metabolism | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6M2CYY0	Glycine--tRNA ligase		722	Unreviewed	Cytoplasm | Mitochondrion	mitochondrial glycyl-tRNA aminoacylation	ATP binding | glycine-tRNA ligase activity | transferase activity	mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Cytoplasm | Ligase | Mitochondrion | Nucleotide-binding | Protein biosynthesis | Transferase | Transit peptide		Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. Required for terminal arborization of both dendrites and axons during development
Rhipicephalus microplus	6941	A0A6M2D0J6	DNA replication licensing factor MCM4		874	Unreviewed	Nucleus	DNA strand elongation involved in DNA replication | double-strand break repair via break-induced replication | mitotic DNA replication initiation	ATP binding | hydrolase activity | single-stranded DNA binding | single-stranded DNA helicase activity	MCM complex | nucleus	ATP-binding | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Rhipicephalus microplus	6941	A0A6M2CQP0	Ubiquitin-conjugating enzyme E2 C		179	Unreviewed		cell division	ATP binding | ubiquitin conjugating enzyme activity		ATP-binding | Cell cycle | Cell division | Mitosis | Nucleotide-binding | Transferase | Ubl conjugation | Ubl conjugation pathway		Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit
Rhipicephalus microplus	6941	A0A6M2CWA2	CAAX prenyl protease		488	Unreviewed	Endoplasmic reticulum membrane	CAAX-box protein processing	metal ion binding | metalloendopeptidase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | Hydrolase | Membrane | Metal-binding | Metalloprotease | Protease | Transmembrane | Transmembrane helix | Zinc		Proteolytically removes the C-terminal three residues of farnesylated proteins
Rhipicephalus microplus	6941	A0A6M2CW48	CTP synthase		749	Unreviewed		'de novo' CTP biosynthetic process | pyrimidine nucleobase biosynthetic process	ATP binding | CTP synthase activity | identical protein binding | lyase activity	cytoophidium | cytoplasm	ATP-binding | Glutamine amidotransferase | Ligase | Lyase | Nucleotide-binding | Pyrimidine biosynthesis		Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides
Rhipicephalus microplus	6941	A0A6M2CTE5	4-hydroxyphenylpyruvate dioxygenase		382	Unreviewed	Cytoplasm | Endoplasmic reticulum membrane | Golgi apparatus membrane	L-phenylalanine catabolic process | L-tyrosine catabolic process	4-hydroxyphenylpyruvate dioxygenase activity | lactoylglutathione lyase activity | metal ion binding | protein homodimerization activity	endoplasmic reticulum membrane | Golgi membrane	Cytoplasm | Dioxygenase | Endoplasmic reticulum | Golgi apparatus | Iron | Membrane | Metal-binding | Oxidoreductase | Phenylalanine catabolism | Pyruvate | Repeat | Tyrosine catabolism		Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism
Rhipicephalus microplus	6941	A0A6M2CTD3	Eukaryotic translation initiation factor 3 subunit B		718	Unreviewed	Cytoplasm	formation of cytoplasmic translation initiation complex	RNA binding | translation initiation factor activity | translation initiation factor binding	eukaryotic 43S preinitiation complex | eukaryotic 48S preinitiation complex | eukaryotic translation initiation factor 3 complex	Coiled coil | Cytoplasm | Initiation factor | Protein biosynthesis | RNA-binding | WD repeat		Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome
Rhipicephalus microplus	6941	A0A6M2CT85	E3 ubiquitin-protein ligase		303	Unreviewed	Cytoplasm, cytosol	protein autoubiquitination | ubiquitin-dependent protein catabolic process | Wnt signaling pathway	poly-ADP-D-ribose binding | ubiquitin protein ligase activity | zinc ion binding	cytosol | nucleus	Cytoplasm | Metal-binding | Transferase | Ubl conjugation pathway | Wnt signaling pathway | Zinc | Zinc-finger		E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation
Rhipicephalus microplus	6941	A0A6M2CSR8	Presenilin		413	Unreviewed	Endoplasmic reticulum membrane | Golgi apparatus membrane	amyloid-beta formation | calcium ion homeostasis | membrane protein ectodomain proteolysis | Notch signaling pathway | protein processing	aspartic endopeptidase activity, intramembrane cleaving	endoplasmic reticulum membrane | gamma-secretase complex | Golgi membrane	Endoplasmic reticulum | Golgi apparatus | Hydrolase | Membrane | Notch signaling pathway | Protease | Transmembrane | Transmembrane helix		Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors
Rhipicephalus microplus	6941	A0A6M2CSM2	ATP-dependent DNA helicase 2 subunit 1		600	Unreviewed	Nucleus	DNA recombination | double-strand break repair via nonhomologous end joining | telomere maintenance	ATP binding | damaged DNA binding | DNA helicase activity | double-stranded DNA binding | hydrolase activity | kinase activity | telomeric DNA binding	Ku70:Ku80 complex	ATP-binding | DNA damage | DNA recombination | DNA repair | DNA-binding | Helicase | Hydrolase | Kinase | Nucleotide-binding | Nucleus | Transferase		
Rhipicephalus microplus	6941	A0A6M2CSH5	Queuine tRNA-ribosyltransferase catalytic subunit 1		357	Unreviewed	Cytoplasm	tRNA modification	metal ion binding | tRNA-guanosine(34) queuine transglycosylase activity	cytosol	Cytoplasm | Glycosyltransferase | Metal-binding | Transferase | tRNA processing | Zinc		Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product
Rhipicephalus microplus	6941	A0A6M2CSF7	Succinate-CoA ligase subunit beta		474	Unreviewed		succinyl-CoA metabolic process | tricarboxylic acid cycle	ATP binding | metal ion binding | succinate-CoA ligase (ADP-forming) activity | succinate-CoA ligase (GDP-forming) activity	mitochondrion | succinate-CoA ligase complex	ATP-binding | Ligase | Magnesium | Metal-binding | Mitochondrion | Nucleotide-binding | Transit peptide | Tricarboxylic acid cycle		GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
Rhipicephalus microplus	6941	A0A6M2CSD4	Ubiquitin-conjugating enzyme E2 S		198	Unreviewed		anaphase-promoting complex-dependent catabolic process | cell division | exit from mitosis	ATP binding | ligase activity | ubiquitin conjugating enzyme activity		ATP-binding | Cell cycle | Cell division | Ligase | Nucleotide-binding | Transferase | Ubl conjugation pathway		
Rhipicephalus microplus	6941	A0A6M2CSB9	dynamin GTPase		679	Unreviewed	Cytoplasm, cytosol | Mitochondrion outer membrane	endocytosis | intracellular distribution of mitochondria | mitochondrial fission | peroxisome fission	GTP binding | GTPase activity | lipid binding | microtubule binding	cytosol | microtubule | mitochondrial outer membrane	Cytoplasm | GTP-binding | Hydrolase | Lipid-binding | Membrane | Mitochondrion | Mitochondrion outer membrane | Nucleotide-binding		
Rhipicephalus microplus	6941	A0A6M2CSA2	Probable ATP-dependent RNA helicase DDX23		754	Unreviewed	Nucleus	mRNA splicing, via spliceosome	ATP binding | hydrolase activity | nucleic acid binding | RNA helicase activity	nucleus	ATP-binding | Helicase | Hydrolase | mRNA processing | mRNA splicing | Nucleotide-binding | Nucleus		Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA
Rhipicephalus microplus	6941	A0A6M2CS62	Formimidoyltransferase-cyclodeaminase		541	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole | Golgi apparatus	L-histidine catabolic process to glutamate and formamide | L-histidine catabolic process to glutamate and formate	folic acid binding | formimidoyltetrahydrofolate cyclodeaminase activity | glutamate formimidoyltransferase activity	centriole | Golgi apparatus	Cytoplasm | Cytoskeleton | Folate-binding | Golgi apparatus | Histidine metabolism | Lyase | Multifunctional enzyme | Transferase		Binds and promotes bundling of vimentin filaments originating from the Golgi
Rhipicephalus microplus	6941	A0A6M2CS44	serine--tRNA ligase		498	Unreviewed	Cytoplasm	seryl-tRNA aminoacylation	ATP binding | serine-tRNA ligase activity	cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Cytoplasm | Ligase | Nucleotide-binding | Protein biosynthesis		
Rhipicephalus microplus	6941	A0A6M2CS36	DNA polymerase		335	Unreviewed	Cytoplasm | Nucleus	base-excision repair | double-strand break repair via nonhomologous end joining	class I DNA-(apurinic or apyrimidinic site) endonuclease activity | DNA binding | DNA-directed DNA polymerase activity | metal ion binding	cytoplasm | nucleus	Cytoplasm | DNA damage | DNA repair | DNA replication | DNA synthesis | DNA-binding | DNA-directed DNA polymerase | Lyase | Magnesium | Metal-binding | Methylation | Nucleotidyltransferase | Nucleus | Sodium | Transferase | Ubl conjugation		DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity
Rhipicephalus microplus	6941	A0A6M2CS15	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]		597	Unreviewed		mRNA processing	flavin adenine dinucleotide binding | RNA binding | tRNA-dihydrouridine47 synthase activity | zinc ion binding		Flavoprotein | FMN | Metal-binding | mRNA processing | NAD | NADP | Oxidoreductase | Repeat | tRNA processing | Zinc | Zinc-finger		Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation
Rhipicephalus microplus	6941	A0A6M2CS11	Anamorsin homolog		278	Unreviewed	Cytoplasm | Mitochondrion intermembrane space	iron-sulfur cluster assembly	2 iron, 2 sulfur cluster binding | 4 iron, 4 sulfur cluster binding | electron transfer activity | metal ion binding	mitochondrial intermembrane space	2Fe-2S | 4Fe-4S | Cytoplasm | Iron | Iron-sulfur | Metal-binding | Mitochondrion		Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit
Rhipicephalus microplus	6941	A0A6M2CS03	N-terminal amino-acid N(alpha)-acetyltransferase NatA		188	Unreviewed			protein N-terminal-serine acetyltransferase activity | protein-N-terminal-glutamate acetyltransferase activity	NatA complex	Acyltransferase | Reference proteome | Transferase		
Rhipicephalus microplus	6941	A0A6M2CRV6	Dipeptidyl peptidase 3		667	Unreviewed	Cytoplasm	proteolysis	aminopeptidase activity | dipeptidyl-peptidase activity | metalloexopeptidase activity | zinc ion binding	cytoplasm	Acetylation | Aminopeptidase | Cytoplasm | Hydrolase | Metal-binding | Metalloprotease | Protease | Zinc		
Rhipicephalus microplus	6941	A0A6M2CRT2	Serine/threonine-protein kinase ULK3		463	Unreviewed	Cytoplasm	autophagosome assembly | autophagy of mitochondrion | piecemeal microautophagy of the nucleus | regulation of autophagy | response to starvation | reticulophagy	ATP binding | protein serine/threonine kinase activity	autophagosome | cytosol | phagophore assembly site membrane	ATP-binding | Autophagy | Cytoplasm | Kinase | Nucleotide-binding | Repeat | Serine/threonine-protein kinase | Transferase		
Rhipicephalus microplus	6941	A0A6M2CRF5	RuvB-like helicase		456	Unreviewed	Nucleus	chromatin organization | DNA recombination | DNA repair | positive regulation of gene expression | regulation of canonical Wnt signaling pathway | regulation of cell population proliferation	ATP binding | DNA helicase activity | hydrolase activity | transcription coregulator activity	histone acetyltransferase complex | nucleus	ATP-binding | Chromatin regulator | DNA damage | DNA recombination | DNA repair | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Transcription | Transcription regulation		Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair
Rhipicephalus microplus	6941	A0A6M2CRE5	Bifunctional lysine-specific demethylase and histidyl-hydroxylase		494	Unreviewed	Nucleus, nucleolus	methylation | ribosome biogenesis	histone H3K36me/H3K36me2 demethylase activity | histone H3K4 demethylase activity | iron ion binding | methyltransferase activity | peptidyl-histidine dioxygenase activity	nucleolus	Dioxygenase | Iron | Metal-binding | Methyltransferase | Nucleus | Oxidoreductase | Ribosome biogenesis | Transcription | Transcription regulation | Transferase		Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles
Rhipicephalus microplus	6941	A0A6M2CRC5	Eukaryotic translation initiation factor 5B		1293	Unreviewed	Cytoplasm		GTP binding | GTPase activity | metal ion binding | translation initiation factor activity	mitochondrion	Coiled coil | Cytoplasm | GTP-binding | Hydrolase | Initiation factor | Metal-binding | Nucleotide-binding | Protein biosynthesis		Plays a role in translation initiation. Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after formation of the 80S initiation complex. Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes. In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit
Rhipicephalus microplus	6941	A0A6M2CRC4	Cytochrome c1, heme protein, mitochondrial		317	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	electron transfer activity | heme binding | metal ion binding	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
Rhipicephalus microplus	6941	A0A6M2CRB1	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial		285	Unreviewed	Mitochondrion inner membrane	respiratory electron transport chain | tricarboxylic acid cycle	2 iron, 2 sulfur cluster binding | 3 iron, 4 sulfur cluster binding | 4 iron, 4 sulfur cluster binding | electron transfer activity | metal ion binding | succinate dehydrogenase (quinone) activity	mitochondrial inner membrane	2Fe-2S | 3Fe-4S | 4Fe-4S | Iron | Iron-sulfur | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Transit peptide | Tricarboxylic acid cycle		Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)
Rhipicephalus microplus	6941	A0A6M2CR56	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial		307	Unreviewed	Mitochondrion inner membrane	methylation	2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity	extrinsic component of mitochondrial inner membrane	Membrane | Methyltransferase | Mitochondrion | Mitochondrion inner membrane | S-adenosyl-L-methionine | Transferase | Ubiquinone | Ubiquinone biosynthesis		Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Rhipicephalus microplus	6941	A0A6M2CR53	(3R)-3-hydroxyacyl-CoA dehydrogenase		283	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6M2CQZ6	Translation factor GUF1 homolog, mitochondrial		657	Unreviewed	Mitochondrion inner membrane	positive regulation of translation | translation	GTP binding | GTPase activity | mitochondrial ribosome binding	mitochondrial inner membrane | mitochondrial matrix	GTP-binding | Hydrolase | Membrane | Mitochondrion | Mitochondrion inner membrane | Nucleotide-binding | Protein biosynthesis | Reference proteome		Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner
Rhipicephalus microplus	6941	A0A6M2CQZ3	Autophagy protein 5		270	Unreviewed	Cytoplasm | Preautophagosomal structure membrane	apoptotic process | autophagosome assembly | autophagy of mitochondrion | cellular response to nitrogen starvation | immune system process | negative regulation of programmed cell death | piecemeal microautophagy of the nucleus	Atg8-family ligase activity	Atg12-Atg5-Atg16 complex | autophagosome | mitochondria-associated endoplasmic reticulum membrane contact site | phagophore | phagophore assembly site membrane	Acetylation | Apoptosis | Autophagy | Cytoplasm | Immunity | Isopeptide bond | Membrane | Ubl conjugation		Involved in autophagic vesicle formation
Rhipicephalus microplus	6941	A0A6M2CTG4	Heat shock protein 75 kDa, mitochondrial		694	Unreviewed	Mitochondrion inner membrane | Mitochondrion matrix		ATP binding | ATP hydrolysis activity | ATP-dependent protein folding chaperone | protein kinase binding | unfolded protein binding	mitochondrial inner membrane | mitochondrial matrix	Acetylation | ATP-binding | Chaperone | Membrane | Mitochondrion | Mitochondrion inner membrane | Nucleotide-binding | Phosphoprotein | Receptor | Signal | Transit peptide		Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA
Rhipicephalus microplus	6941	A0A6M2CTG7	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial		285	Unreviewed	Mitochondrion inner membrane	respiratory electron transport chain | tricarboxylic acid cycle	2 iron, 2 sulfur cluster binding | 3 iron, 4 sulfur cluster binding | 4 iron, 4 sulfur cluster binding | electron transfer activity | metal ion binding | succinate dehydrogenase (quinone) activity	mitochondrial inner membrane	2Fe-2S | 3Fe-4S | 4Fe-4S | Iron | Iron-sulfur | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Reference proteome | Transit peptide | Tricarboxylic acid cycle		Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)
Rhipicephalus microplus	6941	A0A6M2CTJ2	Exosome complex component RRP45		428	Unreviewed	Cytoplasm | Nucleus, nucleolus	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | nuclear mRNA surveillance | nuclear polyadenylation-dependent rRNA catabolic process | rRNA catabolic process | TRAMP-dependent tRNA surveillance pathway | U1 snRNA 3'-end processing | U4 snRNA 3'-end processing | U5 snRNA 3'-end processing	mRNA 3'-UTR AU-rich region binding	cytoplasmic exosome (RNase complex) | nuclear exosome (RNase complex) | nucleolus	Cytoplasm | Exosome | Nucleus | RNA-binding | rRNA processing		
Rhipicephalus microplus	6941	A0A6M2CTJ7	Ras-related protein Rab-35		200	Unreviewed	Cell membrane | Cytoplasmic vesicle, clathrin-coated vesicle | Endosome | Melanosome | Membrane, clathrin-coated pit	protein transport	G protein activity | GTP binding | metal ion binding	clathrin-coated pit | clathrin-coated vesicle | endosome | plasma membrane	Cell membrane | Coated pit | Cytoplasmic vesicle | Endosome | GTP-binding | Hydrolase | Lipoprotein | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Prenylation | Protein transport | Reference proteome | Transport		
Rhipicephalus microplus	6941	A0A6M2CW17	dual-specificity kinase		426	Unreviewed		actin cytoskeleton organization	ATP binding | metal ion binding | protein serine/threonine kinase activity | protein serine/threonine/tyrosine kinase activity | protein tyrosine kinase activity	cytoplasm | nucleus	ATP-binding | Kinase | Magnesium | Manganese | Metal-binding | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Transferase | Tyrosine-protein kinase		
Rhipicephalus microplus	6941	A0A6M2CVY1	Methionine--tRNA ligase, cytoplasmic		930	Unreviewed	Cytoplasm	methionyl-tRNA aminoacylation	ATP binding | methionine-tRNA ligase activity | RNA binding	aminoacyl-tRNA synthetase multienzyme complex | cytoplasmic ribonucleoprotein granule | cytosol | methionyl glutamyl tRNA synthetase complex	Aminoacyl-tRNA synthetase | ATP-binding | Cytoplasm | Ligase | Nucleotide-binding | Protein biosynthesis | RNA-binding | Signal		
Rhipicephalus microplus	6941	A0A6M2CVX0	Zinc phosphodiesterase ELAC protein 2		755	Unreviewed	Mitochondrion matrix | Nucleus	mitochondrial tRNA 3'-end processing	3'-tRNA processing endoribonuclease activity | metal ion binding	mitochondrial nucleoid | nucleus	Endonuclease | Hydrolase | Metal-binding | Mitochondrion | Nuclease | Nucleus | Phosphoprotein | Transit peptide | tRNA processing | Zinc		Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly
Rhipicephalus microplus	6941	A0A6M2CVU9	Adenylate kinase isoenzyme 6 homolog		176	Unreviewed	Cytoplasm | Nucleus	ribosomal small subunit biogenesis | rRNA processing	AMP kinase activity | ATP binding | ATP hydrolysis activity	cytoplasm | nucleus	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Nucleus | Reference proteome | Ribosome biogenesis | rRNA processing | Transferase		Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis
Rhipicephalus microplus	6941	A0A6M2CVU6	Acyl-coenzyme A thioesterase 13		161	Unreviewed	Cytoplasm, cytoskeleton, spindle | Cytoplasm, cytosol | Mitochondrion | Nucleus	lipid metabolic process	fatty acyl-CoA hydrolase activity	cytosol | mitochondrion | nucleus | spindle	Acetylation | Cytoplasm | Cytoskeleton | Hydrolase | Lipid metabolism | Mitochondrion | Nucleus		Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis
Rhipicephalus microplus	6941	A0A6M2CVM9	enoyl-CoA hydratase		521	Unreviewed		fatty acid beta-oxidation	enoyl-CoA hydratase activity | long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity | NAD+ binding	mitochondrial fatty acid beta-oxidation multienzyme complex	Fatty acid metabolism | Lipid metabolism | Lyase | Multifunctional enzyme | NAD | Oxidoreductase		
Rhipicephalus microplus	6941	A0A6M2CVM5	DNA repair protein RAD51 homolog		337	Unreviewed	Nucleus	chromosome organization involved in meiotic cell cycle | DNA recombinase assembly | DNA strand invasion | mitotic recombination | mitotic recombination-dependent replication fork processing | reciprocal meiotic recombination	ATP binding | ATP-dependent DNA damage sensor activity | DNA strand exchange activity | double-stranded DNA binding | single-stranded DNA binding	condensed nuclear chromosome	ATP-binding | DNA damage | DNA recombination | DNA repair | DNA-binding | Nucleotide-binding | Nucleus | Reference proteome		Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA
Rhipicephalus microplus	6941	A0A6M2CVL1	Nitrilase and fragile histidine triad fusion protein NitFhit		473	Unreviewed		nucleobase-containing compound metabolic process	bis(5'-adenosyl)-triphosphatase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | nucleotide binding		Hydrolase | Multifunctional enzyme | Nucleotide-binding		Cleaves A-5'-PPP-5'A to yield AMP and ADP
Rhipicephalus microplus	6941	A0A6M2CVG6	ATP-dependent DNA helicase		631	Unreviewed	Nucleus	DNA replication | double-strand break repair via homologous recombination | telomere maintenance	3'-5' DNA helicase activity | ATP binding | DNA binding | four-way junction helicase activity | hydrolase activity	chromosome | cytoplasm | nucleoplasm	ATP-binding | DNA-binding | Helicase | Hydrolase | Isomerase | Nucleotide-binding | Nucleus		
Rhipicephalus microplus	6941	A0A6M2CVC4	General transcription and DNA repair factor IIH helicase/translocase subunit XPB		777	Unreviewed	Nucleus	nucleotide-excision repair | transcription initiation at RNA polymerase II promoter	3'-5' DNA helicase activity | ATP binding | DNA binding | hydrolase activity	nucleotide-excision repair factor 3 complex | transcription factor TFIIH holo complex | transcription preinitiation complex	ATP-binding | DNA damage | DNA repair | DNA-binding | Helicase | Hydrolase | Isomerase | Nucleotide-binding | Nucleus		
Rhipicephalus microplus	6941	A0A6M2CVB9	Phospholipid-transporting ATPase		1102	Unreviewed	Golgi apparatus membrane | Golgi apparatus, trans-Golgi network membrane | Membrane	endocytosis | phospholipid translocation | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ATP binding | ATP hydrolysis activity | ATPase-coupled intramembrane lipid transporter activity | magnesium ion binding	endosome | Golgi membrane | plasma membrane | trans-Golgi network	ATP-binding | Golgi apparatus | Lipid transport | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Translocase | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus microplus	6941	A0A6M2CV60	E3 ubiquitin-protein ligase E3D		375	Unreviewed		proteasome-mediated ubiquitin-dependent protein catabolic process | protein autoubiquitination | protein monoubiquitination | protein polyubiquitination	cyclin binding | ubiquitin conjugating enzyme binding | ubiquitin protein ligase activity	cytosol | nucleus | ubiquitin ligase complex			E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site
Rhipicephalus microplus	6941	A0A6M2CV43	Adenylyltransferase and sulfurtransferase MOCS3 homolog		429	Unreviewed	Cytoplasm, cytosol	Mo-molybdopterin cofactor biosynthetic process | protein urmylation | tRNA wobble position uridine thiolation	adenylyltransferase activity | ATP binding | metal ion binding | thiosulfate-cyanide sulfurtransferase activity | URM1 activating enzyme activity	cytosol	ATP-binding | Coiled coil | Cytoplasm | Metal-binding | Molybdenum cofactor biosynthesis | Multifunctional enzyme | Nucleotide-binding | Transferase | tRNA processing | Zinc		Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions
Rhipicephalus microplus	6941	A0A6M2CW54	Mothers against decapentaplegic homolog		629	Unreviewed	Cytoplasm | Nucleus	anatomical structure morphogenesis | BMP signaling pathway | cell differentiation | dauer larval development | regulation of developmental process | regulation of multicellular organismal process | SMAD protein signal transduction	DNA-binding transcription factor activity, RNA polymerase II-specific | I-SMAD binding | metal ion binding | RNA polymerase II cis-regulatory region sequence-specific DNA binding	cytoplasm | heteromeric SMAD protein complex	Coiled coil | Cytoplasm | DNA-binding | Metal-binding | Nucleus | Receptor | Transcription | Transcription regulation | Zinc		
Rhipicephalus microplus	6941	A0A6M2CUZ9	Ubiquinone biosynthesis O-methyltransferase, mitochondrial		287	Unreviewed	Mitochondrion inner membrane	methylation	3-demethylubiquinol 3-O-methyltransferase activity | metal ion binding | polyprenyldihydroxybenzoate methyltransferase activity	extrinsic component of mitochondrial inner membrane	Magnesium | Membrane | Metal-binding | Methyltransferase | Mitochondrion | Mitochondrion inner membrane | S-adenosyl-L-methionine | Transferase | Ubiquinone biosynthesis		O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol
Rhipicephalus microplus	6941	A0A6M2CUV2	Cystathionine beta-synthase		550	Unreviewed	Cytoplasm | Nucleus	cysteine biosynthetic process from serine | cysteine biosynthetic process via cystathionine | homocysteine metabolic process	cystathionine beta-synthase activity | metal ion binding | pyridoxal phosphate binding	cytoplasm | nucleus	Amino-acid biosynthesis | CBS domain | Cysteine biosynthesis | Cytoplasm | Heme | Iron | Isopeptide bond | Lyase | Metal-binding | Nucleus | Phosphoprotein | Pyridoxal phosphate | Ubl conjugation		Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons
Rhipicephalus microplus	6941	A0A6M2CUT4	Lipoyl synthase, mitochondrial		376	Unreviewed	Mitochondrion	protein lipoylation	4 iron, 4 sulfur cluster binding | lipoate synthase activity | metal ion binding	mitochondrion	4Fe-4S | Iron | Iron-sulfur | Metal-binding | Mitochondrion | S-adenosyl-L-methionine | Transferase		Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Rhipicephalus microplus	6941	A0A6M2CUR5	Probable ATP-dependent RNA helicase DDX46		864	Unreviewed	Nucleus speckle	mRNA splicing, via spliceosome	ATP binding | hydrolase activity | nucleic acid binding | RNA helicase activity	nuclear speck | spliceosomal complex	ATP-binding | Coiled coil | Helicase | Hydrolase | mRNA processing | mRNA splicing | Nucleotide-binding | Nucleus | Spliceosome		Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site
Rhipicephalus microplus	6941	A0A6M2CUI5	4-hydroxybenzoate polyprenyltransferase, mitochondrial		372	Unreviewed	Membrane | Mitochondrion inner membrane	isoprenoid biosynthetic process | ubiquinone biosynthetic process	4-hydroxybenzoate polyprenyltransferase activity	mitochondrial inner membrane	Isoprene biosynthesis | Membrane | Mitochondrion | Mitochondrion inner membrane | Transferase | Transmembrane | Transmembrane helix | Ubiquinone biosynthesis		Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate
Rhipicephalus microplus	6941	A0A6M2CUG3	RNA-splicing ligase RtcB homolog		506	Unreviewed		tRNA splicing, via endonucleolytic cleavage and ligation	GTP binding | metal ion binding | RNA ligase (ATP) activity | RNA ligase (GTP) activity	nucleus | tRNA-splicing ligase complex	GTP-binding | Ligase | Manganese | Metal-binding | Nucleotide-binding | tRNA processing		Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs
Rhipicephalus microplus	6941	A0A6M2CUC8	Inositol-tetrakisphosphate 1-kinase		340	Unreviewed		inositol trisphosphate metabolic process	ATP binding | inositol-1,3,4-trisphosphate 5-kinase activity | inositol-1,3,4-trisphosphate 6-kinase activity | inositol-3,4,5,6-tetrakisphosphate 1-kinase activity | magnesium ion binding	cytoplasm	ATP-binding | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Transferase		Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3
Rhipicephalus microplus	6941	A0A6M2CU63	Meiotic recombination protein DMC1/LIM15 homolog		340	Unreviewed	Nucleus	chromosome organization involved in meiotic cell cycle | DNA recombinase assembly | DNA strand invasion | mitotic recombination | reciprocal meiotic recombination	ATP binding | ATP-dependent DNA damage sensor activity | DNA strand exchange activity | double-stranded DNA binding | single-stranded DNA binding	condensed nuclear chromosome	ATP-binding | Cell cycle | DNA-binding | Meiosis | Nucleotide-binding | Nucleus | Reference proteome		Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks
Rhipicephalus microplus	6941	A0A6M2CU50	RuvB-like helicase		463	Unreviewed	Nucleus	chromatin organization | DNA repair | positive regulation of macromolecule biosynthetic process | regulation of canonical Wnt signaling pathway | regulation of cell population proliferation	ATP binding | DNA helicase activity | hydrolase activity | transcription coregulator activity	histone acetyltransferase complex | nucleus	ATP-binding | Chromatin regulator | DNA damage | DNA repair | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Transcription | Transcription regulation		Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair
Rhipicephalus microplus	6941	A0A6M2CTV1	Short-chain specific acyl-CoA dehydrogenase, mitochondrial		409	Unreviewed		butyrate catabolic process | fatty acid beta-oxidation using acyl-CoA dehydrogenase	flavin adenine dinucleotide binding | short-chain fatty acyl-CoA dehydrogenase activity	mitochondrion	FAD | Flavoprotein | Oxidoreductase		Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains
Rhipicephalus microplus	6941	A0A6M2CTU6	DDB1- and CUL4-associated factor 1		418	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Nucleus	chromatin organization | protein ubiquitination	ATP binding | protein serine/threonine kinase activity	centrosome | Cul4-RING E3 ubiquitin ligase complex | nucleus	Acetylation | ATP-binding | Chromatin regulator | Cytoplasm | Cytoskeleton | Host-virus interaction | Kinase | Nucleotide-binding | Nucleus | Phosphoprotein | Repeat | Serine/threonine-protein kinase | Transcription | Transcription regulation | Transferase | Ubl conjugation pathway | WD repeat		
Rhipicephalus microplus	6941	A0A6M2CTQ2	DNA-(apurinic or apyrimidinic site) endonuclease		353	Unreviewed	Nucleus	base-excision repair	DNA binding | DNA-(apurinic or apyrimidinic site) endonuclease activity | double-stranded DNA 3'-5' DNA exonuclease activity | metal ion binding | phosphoric diester hydrolase activity	nucleus	DNA damage | DNA repair | Hydrolase | Magnesium | Manganese | Metal-binding | Nucleus		
Rhipicephalus microplus	6941	A0A6M2CTN0	Aconitate hydratase, mitochondrial		784	Unreviewed	Mitochondrion	tricarboxylic acid cycle	4 iron, 4 sulfur cluster binding | aconitate hydratase activity | metal ion binding	cytosol | mitochondrion	Iron | Iron-sulfur | Lyase | Metal-binding | Mitochondrion | Transit peptide | Tricarboxylic acid cycle		Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Rhipicephalus microplus	6941	A0A6M2CTJ8	Survival of motor neuron-related-splicing factor 30		282	Unreviewed	Nucleus speckle | Nucleus, Cajal body	mRNA processing | regulation of alternative mRNA splicing, via spliceosome | RNA splicing	RNA binding	Cajal body | cytoplasm | nuclear speck | precatalytic spliceosome	Coiled coil | mRNA processing | mRNA splicing | Nucleus | Spliceosome		Involved in spliceosome assembly
Rhipicephalus microplus	6941	A0A6M2CUZ1	Pre-mRNA-processing factor 19		495	Unreviewed	Nucleus, nucleoplasm	DNA repair | mRNA splicing, via spliceosome | protein K63-linked ubiquitination	ubiquitin protein ligase activity	cytoplasm | nucleoplasm | Prp19 complex | U2-type catalytic step 1 spliceosome	DNA damage | DNA repair | mRNA processing | mRNA splicing | Nucleus | Repeat | Spliceosome | Transferase | Ubl conjugation pathway | WD repeat		Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome
Rhipicephalus microplus	6941	A0A6G5ABU0	Calreticulin		413	Unreviewed	Endoplasmic reticulum lumen	ERAD pathway | protein folding	calcium ion binding | carbohydrate binding | unfolded protein binding	endoplasmic reticulum lumen | endoplasmic reticulum membrane	Calcium | Chaperone | Disulfide bond | Endoplasmic reticulum | Lectin | Metal-binding | Repeat | Signal | Zinc		Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER
Rhipicephalus microplus	6941	A0A6M2CI91	Sphingomyelin phosphodiesterase		592	Unreviewed	Secreted	ceramide biosynthetic process | sphingomyelin catabolic process	acid sphingomyelin phosphodiesterase activity | hydrolase activity, acting on glycosyl bonds | metal ion binding	extracellular space | lysosome | membrane	Disulfide bond | Glycoprotein | Glycosidase | Hydrolase | Metal-binding | Secreted | Signal | Zinc		Converts sphingomyelin to ceramide
Rhipicephalus microplus	6941	A0A6G5AB51	M-phase inducer phosphatase		459	Unreviewed		cell division | developmental process | endomembrane system organization | G2/M transition of mitotic cell cycle | positive regulation of G2/M transition of mitotic cell cycle | positive regulation of G2/MI transition of meiotic cell cycle | regulation of mitotic cell cycle, embryonic	protein tyrosine phosphatase activity	cytoplasm | nucleus	Cell cycle | Cell division | Hydrolase | Mitosis | Protein phosphatase		Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression
Rhipicephalus microplus	6941	A0A0U2EYN8	Cytochrome c oxidase subunit 1	Cox1	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0U2EYN4	Cytochrome c oxidase subunit 1	Cox1	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0U2DH41	Cytochrome c oxidase subunit 1	Cox1	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0U2DDA9	Cytochrome c oxidase subunit 1	Cox1	218	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0H3W741	Cytochrome c oxidase subunit 1		208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0H3W6Z4	Cytochrome c oxidase subunit 1		208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0H3W648	Cytochrome c oxidase subunit 1		208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0H3W5W0	Cytochrome c oxidase subunit 1		208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0H3W5V1	Cytochrome c oxidase subunit 1		208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0F7IRY9	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0F7IRX9	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0F7IQT5	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0F7IPS8	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0F7INJ6	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0F7IN76	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0F7DE21	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0B4PLP2	Stress-activated protein kinase JNK	JNK	345	Unreviewed	Cytoplasm		ATP binding | MAP kinase activity | protein serine kinase activity	cytoplasm	ATP-binding | Kinase | Magnesium | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Signal | Transferase		Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity
Rhipicephalus microplus	6941	A0A0B4PLI5	Mitogen-activated protein kinase		369	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Cytoplasm, cytoskeleton, spindle	apoptotic process	ATP binding | MAP kinase activity	centrosome | spindle	Apoptosis | ATP-binding | Cell cycle | Cytoplasm | Cytoskeleton | Kinase | Magnesium | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Transferase		
Rhipicephalus microplus	6941	A0A0A7DSW7	Phosphotransferase		499	Unreviewed		glucose metabolic process | glycolytic process | intracellular glucose homeostasis	ATP binding | D-glucose binding | fructokinase activity | glucokinase activity	cytosol | mitochondrion	ATP-binding | Glycolysis | Kinase | Nucleotide-binding | Transferase		Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate
Rhipicephalus microplus	6941	A0A0A7DSL5	Citramalyl-CoA lyase, mitochondrial		335	Unreviewed	Mitochondrion	regulation of cobalamin metabolic process	(S)-citramalyl-CoA lyase activity | hydrolase activity | malate synthase activity | metal ion binding	mitochondrion	Acetylation | Hydrolase | Lyase | Magnesium | Metal-binding | Mitochondrion | Transferase | Transit peptide		Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro
Rhipicephalus microplus	6941	A0A059Q6H6	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A059Q5R7	Cytochrome c oxidase subunit 1	COI	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A034WWL1	Calreticulin		411	Unreviewed	Endoplasmic reticulum lumen	ERAD pathway | protein folding	calcium ion binding | carbohydrate binding | unfolded protein binding	endoplasmic reticulum lumen | endoplasmic reticulum membrane	Calcium | Chaperone | Disulfide bond | Endoplasmic reticulum | Lectin | Metal-binding | Repeat | Signal | Zinc		Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER
Rhipicephalus microplus	6941	A0A9J6F3A5	Glucosylceramidase		490	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Reference proteome | Signal | Sphingolipid metabolism		
Rhipicephalus microplus	6941	A0A9J6EXF9	Lysine-specific histone demethylase		793	Unreviewed	Chromosome | Nucleus	DNA repair-dependent chromatin remodeling | negative regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | positive regulation of multicellular organismal process | positive regulation of neural precursor cell proliferation | positive regulation of transcription by RNA polymerase II | regulation of neurogenesis	chromatin binding | enzyme binding | FAD-dependent H3K4me/H3K4me3 demethylase activity | flavin adenine dinucleotide binding | histone H3K9 demethylase activity | MRF binding | RNA binding | RNA polymerase II-specific DNA-binding transcription factor binding | transcription coactivator activity | transcription corepressor activity	chromatin | nucleus	Acetylation | Chromatin regulator | Chromosome | Coiled coil | Developmental protein | FAD | Flavoprotein | Isopeptide bond | Nucleus | Oxidoreductase | Phosphoprotein | Reference proteome | Repressor | Transcription | Transcription regulation | Ubl conjugation		Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3
Rhipicephalus microplus	6941	A0A9J6EUJ6	PRKCA-binding protein		445	Unreviewed	Cytoplasm, cytoskeleton | Cytoplasm, perinuclear region | Membrane | Postsynaptic density | Synapse, synaptosome	dendritic spine maintenance | intracellular protein transport | positive regulation of receptor internalization | receptor clustering | regulation of Arp2/3 complex-mediated actin nucleation	actin binding | metal ion binding | phospholipid binding | protein domain specific binding | protein kinase C binding	cytoskeleton | neuron projection | perinuclear region of cytoplasm | plasma membrane | postsynaptic density | postsynaptic early endosome | synaptic vesicle | trans-Golgi network membrane	Actin-binding | Calcium | Cytoplasm | Cytoskeleton | Lipoprotein | Membrane | Metal-binding | Palmitate | Phosphoprotein | Reference proteome | Synapse | Synaptosome | Zinc		Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function
Rhipicephalus microplus	6941	A0A9J6EMN7	Flavin-containing monooxygenase		547	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Reference proteome | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Rhipicephalus microplus	6941	A0A0U2EYP7	Cytochrome c oxidase subunit 1	Cox1	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0U2EYT1	Cytochrome c oxidase subunit 1	Cox1	218	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A0U2EZ21	Cytochrome c oxidase subunit 1	Cox1	210	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A1B0UVP5	Cytochrome c oxidase subunit 1	COX1	230	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2U8T6B2	Catalase		499	Unreviewed		hydrogen peroxide catabolic process | response to hydrogen peroxide	catalase activity | heme binding | metal ion binding	mitochondrion | peroxisome	Heme | Hydrogen peroxide | Iron | Metal-binding | Oxidoreductase | Peroxidase		Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide
Rhipicephalus microplus	6941	A0A2U8T666	isocitrate dehydrogenase (NADP(+))		418	Unreviewed		glyoxylate cycle | isocitrate metabolic process | NADP+ metabolic process | tricarboxylic acid cycle	isocitrate dehydrogenase (NADP+) activity | magnesium ion binding | NAD binding	mitochondrion	Glyoxylate bypass | Magnesium | Manganese | Metal-binding | NADP | Oxidoreductase | Tricarboxylic acid cycle		
Rhipicephalus microplus	6941	A0A2S0X9F6	Cytochrome c oxidase subunit 1	COI	501	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2S0X9F3	Cytochrome c oxidase subunit 1	COI	498	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2S0X9F2	Cytochrome c oxidase subunit 1	COI	506	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2I7YC11	Cytochrome c oxidase subunit 1	COI	220	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2I7YC08	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2I7YBZ2	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2I7YBY0	Cytochrome c oxidase subunit 1	COI	221	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2I6EDJ0	NAD(P)H oxidase (H2O2-forming)	DuoxA	1491	Unreviewed	Apical cell membrane	cuticle development | defense response to bacterium | hydrogen peroxide catabolic process | molting cycle | post-embryonic animal morphogenesis | response to oxidative stress | superoxide anion generation	calcium ion binding | heme binding | NAD(P)H oxidase H2O2-forming activity | peroxidase activity | superoxide-generating NAD(P)H oxidase activity	apical plasma membrane | NADPH oxidase complex	Calcium | FAD | Flavoprotein | Glycoprotein | Heme | Hydrogen peroxide | Iron | Membrane | Metal-binding | NADP | Oxidoreductase | Peroxidase | Repeat | Signal | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A2H5BXL9	Cytochrome c oxidase subunit 1	COI	195	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2H4U9U1	Cytochrome c oxidase subunit 1	COI	196	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2D0Y6X7	Cytochrome c oxidase subunit 1	COI	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A9J6EDF2	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		256	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase | Reference proteome		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Rhipicephalus microplus	6941	A0A2D0Y4C4	Cytochrome c oxidase subunit 1	COI	195	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2D0XQA8	Cytochrome c oxidase subunit 1	COI	210	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2D0XQA5	Cytochrome c oxidase subunit 1	COI	156	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2D0XQ61	Cytochrome c oxidase subunit 1	COI	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A1W6EV11	Cytochrome c oxidase subunit 1		498	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A1P8SGP6	Cytochrome c oxidase subunit 1	cox1	347	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A1P8SGP4	Cytochrome c oxidase subunit 1	cox1	351	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A1P8SGP1	Cytochrome c oxidase subunit 1	cox1	346	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A1P8SGN8	Cytochrome c oxidase subunit 1	cox1	349	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A1P8SGN6	Cytochrome c oxidase subunit 1	cox1	347	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A1P8SGN5	Cytochrome c oxidase subunit 1	cox1	348	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A1B0UVQ2	Cytochrome c oxidase subunit 1	COX1	230	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A1B0UVP9	Cytochrome c oxidase subunit 1	COX1	230	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A1B0UVP7	Cytochrome c oxidase subunit 1	COX1	230	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2D0XR09	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A2U9PDM9	Cytochrome c oxidase subunit 1	COI	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A9J6E8E1	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		275	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase | Reference proteome		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Rhipicephalus microplus	6941	A0A9J6DVB1	Flavin-containing monooxygenase		468	Unreviewed	Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding		Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Reference proteome | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Rhipicephalus microplus	6941	A0A6M2CT44	Trifunctional enzyme subunit alpha, mitochondrial		733	Unreviewed	Mitochondrion inner membrane	fatty acid beta-oxidation	enoyl-CoA hydratase activity | long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity | NAD+ binding | transferase activity	mitochondrial fatty acid beta-oxidation multienzyme complex | mitochondrial inner membrane	Acetylation | Fatty acid metabolism | Lipid metabolism | Lyase | Membrane | Methylation | Mitochondrion | Mitochondrion inner membrane | Multifunctional enzyme | NAD | Oxidoreductase | Phosphoprotein | Transferase | Transit peptide		
Rhipicephalus microplus	6941	A0A6M2CQ08	Trifunctional enzyme subunit alpha, mitochondrial		614	Unreviewed	Mitochondrion inner membrane	fatty acid beta-oxidation	enoyl-CoA hydratase activity | long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity | NAD+ binding | transferase activity	mitochondrial fatty acid beta-oxidation multienzyme complex | mitochondrial inner membrane	Acetylation | Fatty acid metabolism | Lipid metabolism | Lyase | Membrane | Methylation | Mitochondrion | Mitochondrion inner membrane | Multifunctional enzyme | NAD | Oxidoreductase | Phosphoprotein | Transferase | Transit peptide		
Rhipicephalus microplus	6941	A0A6M2CNH1	Alanine--glyoxylate aminotransferase 2, mitochondrial		465	Unreviewed	Mitochondrion	glyoxylate catabolic process | L-alanine catabolic process, by transamination	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity | alanine-glyoxylate transaminase activity | beta-alanine:pyruvate transaminase activity | pyridoxal phosphate binding	mitochondrion	Aminotransferase | Mitochondrion | Pyridoxal phosphate | Transferase | Transit peptide		Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure
Rhipicephalus microplus	6941	A0A6M2CNA9	Flavin-containing monooxygenase 1		423	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Rhipicephalus microplus	6941	A0A6M2CN63	Alanine--glyoxylate aminotransferase 2, mitochondrial		376	Unreviewed	Mitochondrion	glyoxylate catabolic process | L-alanine catabolic process, by transamination	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity | alanine-glyoxylate transaminase activity | beta-alanine:pyruvate transaminase activity | pyridoxal phosphate binding	mitochondrion	Aminotransferase | Mitochondrion | Pyridoxal phosphate | Transferase | Transit peptide		Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure
Rhipicephalus microplus	6941	A0A6M2CN45	Diacylglycerol O-acyltransferase 1		468	Unreviewed	Endoplasmic reticulum membrane	triglyceride biosynthetic process	diacylglycerol O-acyltransferase activity | retinol O-fatty-acyltransferase activity	endoplasmic reticulum membrane	Acyltransferase | Endoplasmic reticulum | Membrane | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6M2CL57	Trifunctional enzyme subunit alpha, mitochondrial		694	Unreviewed	Mitochondrion inner membrane	fatty acid beta-oxidation	enoyl-CoA hydratase activity | long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity | NAD+ binding | transferase activity	mitochondrial fatty acid beta-oxidation multienzyme complex | mitochondrial inner membrane	Acetylation | Fatty acid metabolism | Lipid metabolism | Lyase | Membrane | Methylation | Mitochondrion | Mitochondrion inner membrane | Multifunctional enzyme | NAD | Oxidoreductase | Phosphoprotein | Transferase | Transit peptide		
Rhipicephalus microplus	6941	A0A6G4ZVP6	Alanine--glyoxylate aminotransferase 2, mitochondrial		141	Unreviewed	Mitochondrion	glyoxylate catabolic process | L-alanine catabolic process, by transamination	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity | alanine-glyoxylate transaminase activity | beta-alanine:pyruvate transaminase activity | pyridoxal phosphate binding	mitochondrion	Aminotransferase | Mitochondrion | Pyridoxal phosphate | Transferase | Transit peptide		Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure
Rhipicephalus microplus	6941	P83603	Kunitz-type serine protease inhibitor 2		25	Reviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular region	Direct protein sequencing | Protease inhibitor | Secreted | Serine protease inhibitor		Inhibits bovine trypsin, human plasma kallikrein and human neutrophil elastase
Rhipicephalus microplus	6941	P83606	Kunitz-type serine protease inhibitor 6		291	Reviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Direct protein sequencing | Disulfide bond | Glycoprotein | Protease inhibitor | Repeat | Secreted | Serine protease inhibitor		Inhibits trypsin and plasmin. Does not inhibit human plasma kallikrein, chymotrypsin, human neutrophil elastase, factor Xa, factor XIIa or thrombin
Rhipicephalus microplus	6941	P83607	Kunitz-type serine protease inhibitor D		17	Reviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular region	Direct protein sequencing | Protease inhibitor | Secreted | Serine protease inhibitor		Inhibits bovine trypsin and human plasma kallikrein, but not human neutrophil elastase
Rhipicephalus microplus	6941	P83605	Kunitz-type serine protease inhibitor 4		25	Reviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular region	Direct protein sequencing | Protease inhibitor | Secreted | Serine protease inhibitor		Inhibits trypsin, human plasma kallikrein and human neutrophil elastase
Rhipicephalus microplus	6941	P83604	Kunitz-type serine protease inhibitor 3		27	Reviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular region	Direct protein sequencing | Protease inhibitor | Secreted | Serine protease inhibitor		Inhibits bovine trypsin and human neutrophil elastase
Rhipicephalus microplus	6941	P81162	Protease inhibitor carrapatin		69	Reviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Direct protein sequencing | Disulfide bond | Protease inhibitor | Secreted | Serine protease inhibitor		Serine protease inhibitor
Rhipicephalus microplus	6941	P20736	Glycoprotein antigen BM86		650	Reviewed	Cell membrane			plasma membrane | side of membrane	Cell membrane | Direct protein sequencing | Disulfide bond | EGF-like domain | Glycoprotein | GPI-anchor | Lipoprotein | Membrane | Repeat | Signal		
Rhipicephalus microplus	6941	O97162	Tropomyosin		284	Reviewed					Coiled coil | Repeat		Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction
Rhipicephalus microplus	6941	P83609	Kunitz-type serine protease inhibitor A		121	Reviewed	Secreted		serine-type endopeptidase inhibitor activity	extracellular space	Direct protein sequencing | Disulfide bond | Glycoprotein | Protease inhibitor | Repeat | Secreted | Serine protease inhibitor		Serine protease inhibitor (PubMed:10615008, PubMed:15556274, PubMed:26921038). Inhibits bovine trypsin, bovine chymotrypsin, human plasmin, human plasma kallikrein and human neutrophil elastase, but not bovine thrombin, human factor Xa or porcine pancreatic kallikrein (PubMed:10615008, PubMed:15556274, PubMed:26921038). Reduces cell viability and inhibits capillary tube formation in vitro probably by reducing bradykinin release (PubMed:26921038). May play a role in blocking blood coagulation during the larvae fixation on cattle
Rhipicephalus microplus	6941	Q8WPI3	Boophilin-G2		142	Reviewed	Secreted		serine-type endopeptidase inhibitor activity | toxin activity	extracellular space	Blood coagulation cascade inhibiting toxin | Direct protein sequencing | Disulfide bond | Hemostasis impairing toxin | Protease inhibitor | Pyrrolidone carboxylic acid | Repeat | Secreted | Serine protease inhibitor | Signal | Toxin		Midgut thrombin inhibitor that plays a major role in keeping the midgut microenvironment at low hemostatic and inflammatory tonus (PubMed:18286181, PubMed:26745503). Also inhibits FXIa (F11), kallikrein (KLK1), neutrophil elastase (ELANE) and cathepsin G (CTSG), which play a role in the contact pathway of the coagulation cascade (PubMed:18286181, PubMed:26745503). Also abrogates platelet aggregation by cathepsin G and plasmin, and attenuates tissue factor (F3) pathway inhibitor cleavage by elastase (PubMed:18286181, PubMed:26745503). In vivo, inhibits thrombosis and promotes bleeding in mice (PubMed:26745503)
Rhipicephalus microplus	6941	P83516	Chymotrypsin-elastase inhibitor ixodidin		65	Reviewed	Secreted	defense response to bacterium	serine-type endopeptidase inhibitor activity	extracellular region	Antibiotic | Antimicrobial | Direct protein sequencing | Disulfide bond | Protease inhibitor | Pyrrolidone carboxylic acid | Secreted | Serine protease inhibitor		Inhibits chymotrypsin and elastase. Has antibacterial activity against Gram-positive bacterium M.luteus and the Gram-negative bacterium E.coli
Rhipicephalus microplus	6941	Q86RN8	Paramyosin	PRM	873	Reviewed	Cytoplasm, myofibril	myofibril assembly		bicellular tight junction | myofibril | myosin complex | myosin filament	Coiled coil | Cytoplasm | Motor protein | Muscle protein | Myosin | Thick filament		Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles
Rhipicephalus microplus	6941	Q86LE4	Defensin		74	Reviewed	Secreted	defense response to Gram-negative bacterium | defense response to Gram-positive bacterium | innate immune response		extracellular region	Antibiotic | Antimicrobial | Cleavage on pair of basic residues | Defensin | Direct protein sequencing | Disulfide bond | Immunity | Innate immunity | Secreted | Signal		Antibacterial peptide mostly active against Gram-positive bacteria
Rhipicephalus microplus	6941	P85044	Periviscerokinin		9	Reviewed	Secreted	neuropeptide signaling pathway | regulation of smooth muscle contraction		extracellular region	Amidation | Direct protein sequencing | Neuropeptide | Secreted		Mediates visceral muscle contractile activity (myotropic activity)
Rhipicephalus microplus	6941	A0A158RFT4	Complement inhibitor RaCI2		98	Reviewed	Secreted		toxin activity	extracellular region	3D-structure | Complement system impairing toxin | Disulfide bond | Secreted | Signal | Toxin	5HCD | 5IEC	Complement inhibitor (PubMed:27018802). Prevents complement-mediated C5 activation by binding to C5 (PubMed:27018802). Binds C5 at a different binding site than the other tick complement inhibitors OmCI and CirpT1, and the drug eculizumab (By similarity)
Rhipicephalus microplus	6941	Q8WPI2	Boophilin-H2		142	Reviewed	Secreted		serine-type endopeptidase inhibitor activity | toxin activity	extracellular space	3D-structure | Blood coagulation cascade inhibiting toxin | Direct protein sequencing | Disulfide bond | Hemostasis impairing toxin | Platelet aggregation inhibiting toxin | Protease inhibitor | Pyrrolidone carboxylic acid | Repeat | Secreted | Serine protease inhibitor | Signal | Toxin	2ODY	Midgut thrombin inhibitor that plays a major role in keeping the midgut microenvironment at low hemostatic and inflammatory tonus (By similarity) (PubMed:18286181). Also inhibits FXIa (F11), kallikrein (KLK1), neutrophil elastase (ELANE) and cathepsin G (CTSG), which play a role in the contact pathway of the coagulation cascade (By similarity) (PubMed:18286181). Also abrogates platelet aggregation by cathepsin G and plasmin, and attenuates tissue factor (F3) pathway inhibitor cleavage by elastase (By similarity) (PubMed:18286181). In vivo, inhibits thrombosis and promotes bleeding in mice (By similarity)
Rhipicephalus microplus	6941	P52307	Protein 5NUC		580	Reviewed	Cell membrane	AMP catabolic process	5'-nucleotidase activity | metal ion binding | nucleotide binding | UDP-sugar diphosphatase activity	plasma membrane | side of membrane	Cell membrane | Direct protein sequencing | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipoprotein | Membrane | Metal-binding | Nucleotide-binding | Signal | Zinc		Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell
Rhipicephalus microplus	6941	Q86LE5	Antimicrobial peptide microplusin		110	Reviewed	Secreted	defense response to fungus | defense response to Gram-positive bacterium | innate immune response | killing of cells of another organism	copper chaperone activity | iron ion binding | metal chelating activity	extracellular region	3D-structure | Antibiotic | Antimicrobial | Copper | Direct protein sequencing | Disulfide bond | Fungicide | Immunity | Innate immunity | Metal-binding | Secreted | Signal	2KNJ	Has bacteriostatic activity against the Gram-positive bacterium M.luteus, but not against Gram-negative bacterium E.coli SBS363. Has fungistatic activity against C.neoformans, but not C.albicans. Binds and sequesters copper and iron ions. Copper-chelating is crucial for antimicrobial activity against M.luteus
Rhipicephalus microplus	6941	A0A6G5AB71	Autophagy protein 5		265	Unreviewed	Cytoplasm | Preautophagosomal structure membrane	apoptotic process | autophagosome assembly | autophagy of mitochondrion | cellular response to nitrogen starvation | immune system process | negative regulation of programmed cell death | piecemeal microautophagy of the nucleus	Atg8-family ligase activity	Atg12-Atg5-Atg16 complex | autophagosome | mitochondria-associated endoplasmic reticulum membrane contact site | phagophore | phagophore assembly site membrane	Acetylation | Apoptosis | Autophagy | Cytoplasm | Immunity | Isopeptide bond | Membrane | Ubl conjugation		Involved in autophagic vesicle formation
Rhipicephalus microplus	6941	A0A9J6CU81	Alanine--glyoxylate aminotransferase 2, mitochondrial		137	Unreviewed	Mitochondrion	glyoxylate catabolic process | L-alanine catabolic process, by transamination	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity | alanine-glyoxylate transaminase activity | beta-alanine:pyruvate transaminase activity | pyridoxal phosphate binding	mitochondrion	Aminotransferase | Pyridoxal phosphate | Reference proteome | Transferase		Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure
Rhipicephalus microplus	6941	A0A9J6DQW6	Hormone-sensitive lipase		760	Unreviewed	Cell membrane | Cytoplasm, cytosol | Lipid droplet | Membrane, caveola	cholesterol metabolic process | triglyceride catabolic process	monoacylglycerol lipase activity | sterol ester esterase activity | triacylglycerol lipase activity	caveola | cytosol | lipid droplet	Cell membrane | Cholesterol metabolism | Cytoplasm | Hydrolase | Lipid degradation | Lipid droplet | Lipid metabolism | Membrane | Phosphoprotein | Reference proteome | Steroid metabolism | Sterol metabolism		
Rhipicephalus microplus	6941	A0A9J6E9V3	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D		513	Unreviewed	Early endosome membrane | Endosome membrane | Golgi apparatus membrane | Nucleus envelope | Nucleus, nucleoplasm	N-acylethanolamine metabolic process | N-acylphosphatidylethanolamine metabolic process | phospholipid catabolic process | RNA 3'-end processing	metal ion binding | N-acylphosphatidylethanolamine-specific phospholipase D activity	early endosome membrane | Golgi membrane | nuclear envelope | nucleoplasm	Acetylation | Endosome | Golgi apparatus | Hydrolase | Lipid degradation | Lipid metabolism | Membrane | Metal-binding | Nucleus | Phospholipid degradation | Phospholipid metabolism | Reference proteome | Zinc		D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs
Rhipicephalus microplus	6941	A0A9J6ETV0	Peptidase M20 dimerisation domain-containing protein		390	Unreviewed		amide biosynthetic process | amide catabolic process | amino acid metabolic process | proteolysis	aminoacylase activity | metal ion binding | peptidase activity		Hydrolase | Metal-binding | Protease | Reference proteome | Zinc		Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles
Rhipicephalus microplus	6941	A0A9J6DQS6	Glucosylceramidase		845	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | glycine biosynthetic process from serine | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process | tetrahydrofolate interconversion	glucosylceramidase activity | glycine hydroxymethyltransferase activity | hexosyltransferase activity | pyridoxal phosphate binding | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Reference proteome | Signal | Sphingolipid metabolism		
Rhipicephalus microplus	6941	A0A9J6DMC4	glycerophosphocholine cholinephosphodiesterase		464	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Rhipicephalus microplus	6941	A0A9J6DM43	glycerophosphocholine cholinephosphodiesterase		375	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Rhipicephalus microplus	6941	A0A9J6DLA6	glycerophosphocholine cholinephosphodiesterase		330	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Rhipicephalus microplus	6941	A0A9J6DHF0	arginine--tRNA ligase		1376	Unreviewed	Cytoplasmic vesicle, clathrin-coated vesicle | Golgi apparatus | Membrane, clathrin-coated pit	arginyl-tRNA aminoacylation | clathrin coat assembly | clathrin-dependent endocytosis | locomotion | synaptic vesicle budding from presynaptic endocytic zone membrane	1-phosphatidylinositol binding | arginine-tRNA ligase activity | ATP binding | clathrin heavy chain binding | phosphatidylinositol-4,5-bisphosphate binding | SNARE binding	clathrin-coated pit | clathrin-coated vesicle | extrinsic component of presynaptic endocytic zone membrane | Golgi apparatus | synaptic vesicle	Aminoacyl-tRNA synthetase | ATP-binding | Coated pit | Cytoplasmic vesicle | Endocytosis | Golgi apparatus | Ligase | Membrane | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Rhipicephalus microplus	6941	A0A9J6DDC6	(3R)-3-hydroxyacyl-CoA dehydrogenase		378	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus microplus	6941	A0A6M2D4Z2	glycerophosphocholine cholinephosphodiesterase		454	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Rhipicephalus microplus	6941	A0A6M2D4Y1	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		243	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Rhipicephalus microplus	6941	A0A6M2CY15	glycerophosphocholine cholinephosphodiesterase		341	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Rhipicephalus microplus	6941	A0A6M2CXJ3	(3R)-3-hydroxyacyl-CoA dehydrogenase		408	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6M2CWM3	Histone acetyltransferase		450	Unreviewed	Mitochondrion | Nucleus	DNA repair-dependent chromatin remodeling | epigenetic regulation of gene expression | hemopoiesis | negative regulation of multicellular organismal process | neurogenesis | regulation of cell differentiation | regulation of mitochondrial transcription	histone H4K16 acetyltransferase activity | zinc ion binding	mitochondrion | MSL complex | NSL complex | NuA4 histone acetyltransferase complex | nucleus | polytene chromosome interband	Acetylation | Activator | Chromatin regulator | Metal-binding | Mitochondrion | Nucleus | Phosphoprotein | Transcription | Transcription regulation | Transferase | Zinc | Zinc-finger		
Rhipicephalus microplus	6941	A0A6M2CV27	Inosine triphosphate pyrophosphatase		200	Unreviewed	Cytoplasm	deoxyribonucleoside triphosphate catabolic process | nucleotide metabolic process	dITP diphosphatase activity | ITP diphosphatase activity | metal ion binding | nucleotide binding | XTP diphosphatase activity	cytoplasm	Cytoplasm | Hydrolase | Magnesium | Manganese | Metal-binding | Nucleotide metabolism | Nucleotide-binding		Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions
Rhipicephalus microplus	6941	A0A6M2CS61	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		256	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Rhipicephalus microplus	6941	A0A9J6E035	Delta-like protein		909	Unreviewed	Membrane	establishment or maintenance of epithelial cell apical/basal polarity | germ-line stem cell population maintenance | gland development | gliogenesis | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | lateral inhibition | negative regulation of developmental process | Notch signaling pathway | ommatidial rotation | positive regulation of neurogenesis | R3/R4 cell differentiation | second mitotic wave involved in compound eye morphogenesis	calcium ion binding | glycosphingolipid binding | Notch binding | receptor ligand activity	apical cortex | apical plasma membrane | cell surface | protein-containing complex	Developmental protein | Differentiation | Disulfide bond | EGF-like domain | Glycoprotein | Membrane | Reference proteome | Repeat | Signal | Transmembrane | Transmembrane helix | Ubl conjugation		Putative Notch ligand involved in the mediation of Notch signaling
Rhipicephalus microplus	6941	A0A6M2CQA9	3-hydroxyacyl-CoA dehydrogenase type-2		296	Unreviewed		androgen metabolic process | estrogen metabolic process | fatty acid metabolic process	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity | androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity | estradiol 17-beta-dehydrogenase [NAD(P)+] activity	mitochondrion	Oxidoreductase		
Rhipicephalus microplus	6941	A0A6M2CMY9	DNA oxidative demethylase ALKBH2		257	Unreviewed	Nucleus, nucleolus | Nucleus, nucleoplasm	DNA alkylation repair	broad specificity oxidative DNA demethylase activity | cytosine C-5 DNA demethylase activity | ferrous iron binding	nucleolus | nucleoplasm	Dioxygenase | DNA damage | DNA repair | Iron | Magnesium | Metal-binding | Nucleus | Oxidoreductase		
Rhipicephalus microplus	6941	A0A6M2CL11	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		304	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Rhipicephalus microplus	6941	A0A6M2CJX7	Lysosomal dipeptide transporter MFSD1		382	Unreviewed	Lysosome membrane		transmembrane transporter activity	lysosomal membrane	Lysosome | Membrane | Sugar transport | Transmembrane | Transmembrane helix | Transport		Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis
Rhipicephalus microplus	6941	A0A6M2CJ55	Glucosylceramidase		533	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Signal | Sphingolipid metabolism		
Rhipicephalus microplus	6941	A0A6M2CIK5	Flavin-containing monooxygenase 5		419	Unreviewed	Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding		Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | NADP | Oxidoreductase | Phosphoprotein | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Rhipicephalus microplus	6941	A0A6M2CIC5	Glucosylceramidase		535	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Signal | Sphingolipid metabolism		
Rhipicephalus microplus	6941	A0A6M2CHG1	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		304	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Rhipicephalus microplus	6941	A0A6M2CH31	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		240	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Rhipicephalus microplus	6941	A0A6G5ACS3	Lysosomal dipeptide transporter MFSD1		273	Unreviewed	Lysosome membrane		transmembrane transporter activity	lysosomal membrane	Lysosome | Membrane | Sugar transport | Transmembrane | Transmembrane helix | Transport		Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis
Rhipicephalus microplus	6941	A0A6G5AB13	PRKCA-binding protein		430	Unreviewed	Cytoplasm, cytoskeleton | Cytoplasm, perinuclear region | Membrane | Postsynaptic density | Synapse, synaptosome	dendritic spine maintenance | intracellular protein transport | positive regulation of receptor internalization | receptor clustering | regulation of Arp2/3 complex-mediated actin nucleation	actin binding | metal ion binding | phospholipid binding | protein domain specific binding | protein kinase C binding	cytoskeleton | neuron projection | perinuclear region of cytoplasm | plasma membrane | postsynaptic density | postsynaptic early endosome | synaptic vesicle | trans-Golgi network membrane	Actin-binding | Calcium | Cytoplasm | Cytoskeleton | Lipoprotein | Membrane | Metal-binding | Palmitate | Phosphoprotein | Synapse | Synaptosome | Zinc		Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function
Rhipicephalus microplus	6941	A0A6G5A8J9	Glucosylceramidase		503	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Signal | Sphingolipid metabolism		
Rhipicephalus microplus	6941	A0A2I6EDJ7	NAD(P)H oxidase (H2O2-forming)	DuoxB	1641	Unreviewed	Apical cell membrane	cuticle development | defense response to bacterium | hydrogen peroxide catabolic process | molting cycle | post-embryonic animal morphogenesis | response to oxidative stress | superoxide anion generation	calcium ion binding | heme binding | NAD(P)H oxidase H2O2-forming activity | peroxidase activity | superoxide-generating NAD(P)H oxidase activity	apical plasma membrane | NADPH oxidase complex	Calcium | FAD | Flavoprotein | Glycoprotein | Heme | Hydrogen peroxide | Iron | Membrane | Metal-binding | NADP | Oxidoreductase | Peroxidase | Repeat | Signal | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	Q8I6X6	Notch-like protein	BOTCH	2428	Unreviewed	Cell membrane | Nucleus | Secreted | Target cell membrane	axon guidance | cell fate specification | circulatory system development | embryonic organ development | exocytosis | formation of animal organ boundary | larval development | Notch signaling pathway | ommatidial rotation | positive regulation of cell population proliferation | positive regulation of neurogenesis | R3/R4 cell differentiation | regulation of cell fate specification | regulation of cell-cell adhesion | regulation of transcription by RNA polymerase II | reproductive structure development | sex differentiation	calcium ion binding	apical plasma membrane | cell surface | CSL-Notch-Mastermind transcription factor complex | cytoplasm | endomembrane system | extracellular region | host cell presynaptic membrane | nucleoplasm | other organism cell membrane | receptor complex	Activator | ANK repeat | Calcium | Cell membrane | Developmental protein | Differentiation | Disulfide bond | EGF-like domain | Exocytosis | Glycoprotein | Membrane | Metal-binding | Neurotoxin | Notch signaling pathway | Nucleus | Presynaptic neurotoxin | Receptor | Repeat | Secreted | Signal | Target cell membrane | Target membrane | Toxin | Transcription | Transcription regulation | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6M2CPX6	Acylglycerol kinase, mitochondrial		434	Unreviewed	Mitochondrion inner membrane | Mitochondrion intermembrane space	ceramide biosynthetic process | glycerolipid metabolic process | sphingosine biosynthetic process	acylglycerol kinase activity | ATP binding | ATP-dependent diacylglycerol kinase activity | ceramide kinase activity	mitochondrial inner membrane | mitochondrial intermembrane space	ATP-binding | Kinase | Lipid metabolism | Membrane | Mitochondrion | Mitochondrion inner membrane | Nucleotide-binding | Transferase		
Rhipicephalus microplus	6941	A0A345S550	Cytochrome c oxidase subunit 1	CO1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A9J6ELB9	Flavin-containing monooxygenase		560	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Reference proteome | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Rhipicephalus microplus	6941	A0A345S553	Cytochrome c oxidase subunit 1	CO1	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6G4ZZ61	3'(2'),5'-bisphosphate nucleotidase 1		284	Unreviewed			3'(2'),5'-bisphosphate nucleotidase activity | inositol-1,4-bisphosphate 1-phosphatase activity | metal ion binding		Hydrolase | Lithium | Magnesium | Metal-binding		
Rhipicephalus microplus	6941	A0A6G4ZZ05	Ubiquitin-conjugating enzyme E2 S		187	Unreviewed		anaphase-promoting complex-dependent catabolic process | cell division | exit from mitosis	ATP binding | ligase activity | ubiquitin conjugating enzyme activity		ATP-binding | Cell cycle | Cell division | Ligase | Nucleotide-binding | Transferase | Ubl conjugation pathway		
Rhipicephalus microplus	6941	A0A6G4ZZ04	Cytochrome c1, heme protein, mitochondrial		308	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	electron transfer activity | heme binding | metal ion binding	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport		Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
Rhipicephalus microplus	6941	A0A6G4ZYZ0	E3 ubiquitin-protein ligase		310	Unreviewed	Target cell membrane	exocytosis | proteasome-mediated ubiquitin-dependent protein catabolic process | protein K63-linked ubiquitination	ubiquitin protein ligase activity	host cell presynaptic membrane | nuclear speck | other organism cell membrane	ANK repeat | Exocytosis | Membrane | Neurotoxin | Presynaptic neurotoxin | Target cell membrane | Target membrane | Toxin | Transferase | Ubl conjugation pathway		E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates
Rhipicephalus microplus	6941	A0A6G4ZYS1	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial		423	Unreviewed	Mitochondrion	succinyl-CoA metabolic process | tricarboxylic acid cycle	ATP binding | GTP binding | magnesium ion binding | succinate-CoA ligase (ADP-forming) activity | succinate-CoA ligase (GDP-forming) activity	mitochondrion | succinate-CoA ligase complex	GTP-binding | Ligase | Magnesium | Metal-binding | Mitochondrion | Nucleotide-binding | Tricarboxylic acid cycle		GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
Rhipicephalus microplus	6941	A0A6G4ZYQ7	Putative serine/threonine kinase		342	Unreviewed	Nucleus	cell division | G2/M transition of mitotic cell cycle | mitotic G2 DNA damage checkpoint signaling | positive regulation of cell cycle process | positive regulation of meiotic cell cycle	ATP binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	nucleus	ATP-binding | Cell cycle | Cell division | Kinase | Mitosis | Nucleotide-binding | Nucleus | Phosphoprotein | Serine/threonine-protein kinase | Transferase		Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia
Rhipicephalus microplus	6941	A0A6G4ZYL5	phosphoacetylglucosamine mutase		546	Unreviewed		carbohydrate metabolic process | cell wall organization | UDP-N-acetylglucosamine biosynthetic process	magnesium ion binding | phosphoacetylglucosamine mutase activity		Carbohydrate metabolism | Cell wall biogenesis/degradation | Isomerase | Magnesium | Metal-binding | Phosphoprotein		Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins
Rhipicephalus microplus	6941	A0A6G4ZYK5	Phosphotransferase		499	Unreviewed		glucose metabolic process | glycolytic process | intracellular glucose homeostasis	ATP binding | D-glucose binding | fructokinase activity | glucokinase activity	cytosol | mitochondrion	ATP-binding | Glycolysis | Kinase | Nucleotide-binding | Transferase		Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate
Rhipicephalus microplus	6941	A0A6G4ZYH7	peptidylamidoglycolate lyase		597	Unreviewed		peptide metabolic process	metal ion binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen | peptidylamidoglycolate lyase activity	extracellular region | membrane	Copper | Disulfide bond | Glycoprotein | Lyase | Membrane | Metal-binding | Monooxygenase | Oxidoreductase | Repeat | Signal | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6G4ZYE5	Dihydropteridine reductase		235	Unreviewed		L-phenylalanine catabolic process | tetrahydrobiopterin biosynthetic process	6,7-dihydropteridine reductase activity | NADH binding | NADPH binding	cytoplasm	NADP | Oxidoreductase | Reference proteome | Tetrahydrobiopterin biosynthesis		Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin
Rhipicephalus microplus	6941	A0A6G4ZYE1	Dihydrolipoyl dehydrogenase		513	Unreviewed		2-oxoglutarate metabolic process | cellular respiration	dihydrolipoyl dehydrogenase (NADH) activity | flavin adenine dinucleotide binding	mitochondrion | oxoglutarate dehydrogenase complex | pyruvate dehydrogenase complex	Disulfide bond | FAD | Flavoprotein | NAD | Nucleotide-binding | Oxidoreductase | Redox-active center		
Rhipicephalus microplus	6941	A0A6G4ZYB4	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial		325	Unreviewed	Mitochondrion	tricarboxylic acid cycle	nucleotide binding | succinate-CoA ligase (ADP-forming) activity | succinate-CoA ligase (GDP-forming) activity	mitochondrion | succinate-CoA ligase complex (ADP-forming)	Ligase | Mitochondrion | Nucleotide-binding | Tricarboxylic acid cycle		Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits
Rhipicephalus microplus	6941	A0A6G4ZYB1	Glycerol-3-phosphate dehydrogenase [NAD(+)]		386	Unreviewed	Cytoplasm	carbohydrate metabolic process | glycerol-3-phosphate catabolic process | glycerophospholipid metabolic process	glycerol-3-phosphate dehydrogenase (NAD+) activity | NAD binding | protein homodimerization activity	cytosol	Cytoplasm | NAD | Oxidoreductase		
Rhipicephalus microplus	6941	A0A6G4ZY89	Cyclin-dependent kinase 12		221	Unreviewed	Nucleus	positive regulation of transcription elongation by RNA polymerase II	ATP binding | cyclin binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	cyclin/CDK positive transcription elongation factor complex	ATP-binding | Kinase | Nucleotide-binding | Nucleus | Serine/threonine-protein kinase | Transferase		
Rhipicephalus microplus	6941	A0A6G4ZY63	Glucosamine-6-phosphate isomerase		288	Unreviewed	Cytoplasm	carbohydrate metabolic process | glucosamine catabolic process | N-acetylglucosamine catabolic process | N-acetylneuraminate catabolic process	glucosamine-6-phosphate deaminase activity | identical protein binding | isomerase activity	cytoplasm	Carbohydrate metabolism | Cytoplasm | Hydrolase | Isomerase		Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway
Rhipicephalus microplus	6941	A0A6G4ZY53	alpha-1,2-Mannosidase		565	Unreviewed	Endoplasmic reticulum	carbohydrate metabolic process | endoplasmic reticulum mannose trimming | response to unfolded protein	calcium ion binding | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum quality control compartment | membrane	Calcium | Endoplasmic reticulum | Glycoprotein | Glycosidase | Hydrolase | Metal-binding | Signal | Unfolded protein response		
Rhipicephalus microplus	6941	A0A6G4ZXZ5	ornithine decarboxylase		439	Unreviewed		putrescine biosynthetic process from arginine, via ornithine	ornithine decarboxylase activity	cytoplasm	Lyase | Polyamine biosynthesis | Pyridoxal phosphate | Reference proteome		Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis
Rhipicephalus microplus	6941	A0A6G4ZXZ1	Mannosyl-oligosaccharide glucosidase		818	Unreviewed	Endoplasmic reticulum membrane	oligosaccharide metabolic process | protein N-linked glycosylation	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | Glycoprotein | Glycosidase | Hydrolase | Membrane | Signal-anchor | Transmembrane | Transmembrane helix		Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor
Rhipicephalus microplus	6941	A0A6G4ZXZ0	Ras-related protein Rab-14		215	Unreviewed	Cytoplasmic vesicle | Early endosome membrane | Golgi apparatus, trans-Golgi network membrane | Recycling endosome	defense response to bacterium | endocytic recycling | Golgi to endosome transport | phagosome maturation | protein transport	G protein activity | GTP binding	cytosol | early endosome membrane | phagocytic vesicle | recycling endosome | trans-Golgi network	Acetylation | Cytoplasmic vesicle | Endosome | Golgi apparatus | GTP-binding | Hydrolase | Lipoprotein | Membrane | Methylation | Nucleotide-binding | Prenylation | Protein transport | Transport		
Rhipicephalus microplus	6941	A0A6G4ZXY8	Aurora kinase		298	Unreviewed	Midbody	chromatin organization | chromosome condensation | cytokinetic process | mitotic sister chromatid segregation	ATP binding | protein serine/threonine kinase activity	midbody	ATP-binding | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase		
Rhipicephalus microplus	6941	A0A6G4ZXY2	Angiotensin-converting enzyme		280	Unreviewed		proteolysis	carboxypeptidase activity | metal ion binding | metallopeptidase activity | peptidyl-dipeptidase activity	membrane	Carboxypeptidase | Disulfide bond | Glycoprotein | Hydrolase | Metal-binding | Metalloprotease | Protease | Signal | Zinc		
Rhipicephalus microplus	6941	A0A6G4ZXM8	thioredoxin-disulfide reductase (NADPH)		470	Unreviewed		cell redox homeostasis | cellular response to oxidative stress | glutathione metabolic process	flavin adenine dinucleotide binding | glutathione-disulfide reductase (NADPH) activity | thioredoxin-disulfide reductase (NADPH) activity	cytosol | mitochondrion	Disulfide bond | FAD | Flavoprotein | NAD | NADP | Nucleotide-binding | Oxidoreductase | Redox-active center | Selenocysteine		Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms
Rhipicephalus microplus	6941	A0A6G4ZXI6	Glycine N-methyltransferase		219	Unreviewed	Cytoplasm	methylation | one-carbon metabolic process | protein homotetramerization | regulation of gluconeogenesis | S-adenosylhomocysteine metabolic process | S-adenosylmethionine metabolic process | sarcosine metabolic process	folic acid binding | glycine binding | glycine N-methyltransferase activity | identical protein binding | S-adenosyl-L-methionine binding	cytosol	Cytoplasm | Folate-binding | Methyltransferase | Phosphoprotein | S-adenosyl-L-methionine | Transferase		
Rhipicephalus microplus	6941	A0A6G4ZXF7	ADP/ATP translocase		299	Unreviewed	Membrane | Mitochondrion inner membrane	mitochondrial ADP transmembrane transport | mitochondrial ATP transmembrane transport | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ATP:ADP antiporter activity	mitochondrial inner membrane	Antiport | Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane
Rhipicephalus microplus	6941	A0A6G4ZXC7	ADP/ATP translocase		332	Unreviewed	Membrane | Mitochondrion inner membrane	mitochondrial ADP transmembrane transport | mitochondrial ATP transmembrane transport	ATP:ADP antiporter activity	mitochondrial inner membrane	Antiport | Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane
Rhipicephalus microplus	6941	A0A6G4ZXB4	Cyclin-dependent kinase 7		298	Unreviewed	Nucleus	cell division | positive regulation of transcription by RNA polymerase II	ATP binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	cytoplasm | transcription factor TFIIK complex	ATP-binding | Cell cycle | Cell division | Kinase | Nucleotide-binding | Nucleus | Phosphoprotein | Serine/threonine-protein kinase | Transferase		
Rhipicephalus microplus	6941	A0A6G4ZX51	GMP reductase		348	Unreviewed		purine nucleobase metabolic process | purine nucleotide metabolic process	GMP reductase activity | metal ion binding	GMP reductase complex	Metal-binding | NADP | Oxidoreductase | Potassium | Purine metabolism		Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
Rhipicephalus microplus	6941	A0A6G4ZZN7	Aurora kinase		274	Unreviewed	Midbody	chromatin organization | chromosome condensation | cytokinetic process | mitotic sister chromatid segregation	ATP binding | protein serine/threonine kinase activity	midbody	ATP-binding | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase		
Rhipicephalus microplus	6941	A0A6G4ZZP0	Adenylate kinase		252	Unreviewed	Cytoplasm, cytosol | Mitochondrion intermembrane space	ADP biosynthetic process | AMP metabolic process | ATP metabolic process	AMP kinase activity | ATP binding	cytosol | mitochondrial intermembrane space	ATP-binding | Cytoplasm | Kinase | Mitochondrion | Nucleotide-binding | Transferase		Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways
Rhipicephalus microplus	6941	A0A6G4ZZQ3	dynamin GTPase		551	Unreviewed	Cytoplasm, cytosol | Mitochondrion outer membrane	endocytosis | intracellular distribution of mitochondria | mitochondrial fission | peroxisome fission	GTP binding | GTPase activity | lipid binding | microtubule binding	cytosol | microtubule | mitochondrial outer membrane	Cytoplasm | GTP-binding | Hydrolase | Lipid-binding | Membrane | Mitochondrion | Mitochondrion outer membrane | Nucleotide-binding		
Rhipicephalus microplus	6941	A0A6G4ZZQ8	Adenylate kinase isoenzyme 6 homolog		176	Unreviewed	Cytoplasm | Nucleus	ribosomal small subunit biogenesis | rRNA processing	AMP kinase activity | ATP binding | ATP hydrolysis activity	cytoplasm | nucleus	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Nucleus | Ribosome biogenesis | rRNA processing | Transferase		Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis
Rhipicephalus microplus	6941	A0A6G5AAY9	RuvB-like helicase		277	Unreviewed	Nucleus	chromatin organization | DNA repair | positive regulation of macromolecule biosynthetic process | regulation of canonical Wnt signaling pathway | regulation of cell population proliferation	ATP binding | DNA helicase activity | hydrolase activity | transcription coregulator activity	histone acetyltransferase complex | nucleus	ATP-binding | Chromatin regulator | DNA damage | DNA repair | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Transcription | Transcription regulation		Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair
Rhipicephalus microplus	6941	A0A345S552	Cytochrome c oxidase subunit 1	CO1	220	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6G5AAV9	K Homology domain-containing protein		209	Unreviewed	Cell projection, neuron projection | Cytoplasm, Stress granule | Perikaryon | Synapse	animal organ development | mRNA transport | nervous system development | positive regulation of long-term neuronal synaptic plasticity | positive regulation of translation | regulation of mRNA stability | regulation of translation at presynapse, modulating synaptic transmission	mRNA 3'-UTR binding | translation regulator activity	cytoplasmic stress granule | neuron projection | nucleus | perikaryon | presynapse | ribonucleoprotein complex	Cell projection | Cytoplasm | Neurogenesis | Repeat | Repressor | Ribonucleoprotein | RNA-binding | Synapse | Translation regulation		
Rhipicephalus microplus	6941	A0A6G5AAF7	Stress-activated protein kinase JNK		232	Unreviewed	Cytoplasm		ATP binding | MAP kinase activity | protein serine kinase activity	cytoplasm	ATP-binding | Kinase | Magnesium | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Signal | Transferase		Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity
Rhipicephalus microplus	6941	A0A6G5AAC9	Ragulator complex protein LAMTOR1		163	Unreviewed	Late endosome membrane | Lysosome membrane	cellular response to amino acid stimulus | cholesterol homeostasis | endosomal transport | lysosome organization | positive regulation of MAPK cascade | positive regulation of TOR signaling | regulation of receptor recycling	guanyl-nucleotide exchange factor activity | molecular adaptor activity	late endosome membrane | lysosomal membrane | membrane raft | Ragulator complex	Endosome | Lipoprotein | Lysosome | Membrane | Myristate | Palmitate		
Rhipicephalus microplus	6941	A0A6G5AA64	MAP/microtubule affinity-regulating kinase 3		441	Unreviewed	Cytoplasm, cell cortex	intracellular signal transduction | microtubule cytoskeleton organization	ATP binding | tau-protein kinase activity	cell cortex	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase		Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1
Rhipicephalus microplus	6941	A0A6G5AA19	Dual serine/threonine and tyrosine protein kinase		896	Unreviewed	Cytoplasm	cellular response to fibroblast growth factor stimulus | negative regulation of apoptotic process | positive regulation of ERK1 and ERK2 cascade | positive regulation of fibroblast growth factor receptor signaling pathway	ATP binding | protein serine/threonine kinase activity | protein serine/threonine/tyrosine kinase activity | protein tyrosine kinase activity	cytoplasm	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Serine/threonine-protein kinase | Transferase | Tyrosine-protein kinase		
Rhipicephalus microplus	6941	A0A6G5A9K8	Ras-related protein Rab-35		203	Unreviewed	Cell membrane | Cytoplasmic vesicle, clathrin-coated vesicle | Endosome | Melanosome | Membrane, clathrin-coated pit	protein transport	G protein activity | GTP binding | metal ion binding	clathrin-coated pit | clathrin-coated vesicle | endosome | plasma membrane	Cell membrane | Coated pit | Cytoplasmic vesicle | Endosome | GTP-binding | Hydrolase | Lipoprotein | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Prenylation | Protein transport | Signal | Transport		
Rhipicephalus microplus	6941	A0A6G5A9I8	calcium/calmodulin-dependent protein kinase		521	Unreviewed		cell communication | memory | regulation of gene expression | signaling	ATP binding | calcium/calmodulin-dependent protein kinase activity | calmodulin binding	axon	ATP-binding | Calmodulin-binding | Kinase | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Transferase		
Rhipicephalus microplus	6941	A0A6G5A8Z5	Anamorsin homolog		278	Unreviewed	Cytoplasm | Mitochondrion intermembrane space	iron-sulfur cluster assembly	2 iron, 2 sulfur cluster binding | 4 iron, 4 sulfur cluster binding | electron transfer activity | metal ion binding	mitochondrial intermembrane space	2Fe-2S | 4Fe-4S | Cytoplasm | Iron | Iron-sulfur | Metal-binding | Mitochondrion		Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit
Rhipicephalus microplus	6941	A0A6G5A8K8	Integrin beta		801	Unreviewed	Cell junction | Cell membrane | Cell projection, lamellipodium membrane | Postsynaptic cell membrane	cell adhesion mediated by integrin | cell migration | cell-matrix adhesion | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | integrin-mediated signaling pathway | positive regulation of cell migration | positive regulation of cell population proliferation	integrin binding | metal ion binding	cell surface | focal adhesion | integrin complex | lamellipodium membrane | postsynaptic membrane	Calcium | Cell adhesion | Cell junction | Cell membrane | Cell projection | Disulfide bond | EGF-like domain | Glycoprotein | Integrin | Magnesium | Membrane | Metal-binding | Phosphoprotein | Postsynaptic cell membrane | Repeat | Signal | Synapse | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6G5A8G6	S-adenosylmethionine decarboxylase proenzyme		335	Unreviewed		spermidine biosynthetic process | spermine biosynthetic process	adenosylmethionine decarboxylase activity	cytosol	Autocatalytic cleavage | Decarboxylase | Lyase | Polyamine biosynthesis | Pyruvate | S-adenosyl-L-methionine | Schiff base | Spermidine biosynthesis | Zymogen		
Rhipicephalus microplus	6941	A0A6G5A8B3	Angiotensin-converting enzyme		447	Unreviewed		proteolysis	carboxypeptidase activity | metal ion binding | metallopeptidase activity | peptidyl-dipeptidase activity	membrane	Carboxypeptidase | Disulfide bond | Glycoprotein | Hydrolase | Metal-binding | Metalloprotease | Protease | Signal | Zinc		
Rhipicephalus microplus	6941	A0A6G4ZWX0	ADP/ATP translocase		317	Unreviewed	Membrane | Mitochondrion inner membrane	mitochondrial ADP transmembrane transport | mitochondrial ATP transmembrane transport | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ATP:ADP antiporter activity	mitochondrial inner membrane	Antiport | Membrane | Mitochondrion | Mitochondrion inner membrane | Repeat | Transmembrane | Transmembrane helix | Transport		ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane
Rhipicephalus microplus	6941	A0A6G5A7F3	Multiple inositol polyphosphate phosphatase 1		312	Unreviewed	Membrane		acid phosphatase activity | bisphosphoglycerate 3-phosphatase activity | inositol phosphate phosphatase activity	membrane	Hydrolase | Membrane | Signal | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A6G5A637	Angiotensin-converting enzyme		447	Unreviewed		proteolysis	carboxypeptidase activity | metal ion binding | metallopeptidase activity | peptidyl-dipeptidase activity	membrane	Carboxypeptidase | Disulfide bond | Glycoprotein | Hydrolase | Metal-binding | Metalloprotease | Protease | Signal | Zinc		
Rhipicephalus microplus	6941	A0A6G5A4P1	Multiple inositol polyphosphate phosphatase 1		471	Unreviewed	Cell membrane		acid phosphatase activity | bisphosphoglycerate 3-phosphatase activity | inositol phosphate phosphatase activity	plasma membrane	Cell membrane | Disulfide bond | Glycoprotein | Hydrolase | Membrane | Signal		
Rhipicephalus microplus	6941	A0A6G5A1G8	E3 ubiquitin-protein ligase KCMF1		409	Unreviewed	Late endosome | Lysosome	monoatomic ion transmembrane transport | regulation of cell communication | regulation of signaling | synaptic signaling	ubiquitin protein ligase activity | zinc ion binding	late endosome | lysosome | plasma membrane | synapse	Endosome | Ion channel | Ion transport | Lysosome | Metal-binding | Transferase | Transport | Ubl conjugation pathway | Zinc | Zinc-finger		
Rhipicephalus microplus	6941	A0A6G5A1C1	Ubiquitin-conjugating enzyme E2 H		154	Unreviewed			ATP binding | ubiquitin conjugating enzyme activity		Acetylation | ATP-binding | Nucleotide-binding | Transferase | Ubl conjugation | Ubl conjugation pathway		Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A
Rhipicephalus microplus	6941	A0A6G5A1A9	RING-box protein 2		104	Unreviewed	Cytoplasm | Nucleus	intracellular signal transduction | proteasome-mediated ubiquitin-dependent protein catabolic process	ligase activity | NEDD8 ligase activity | ubiquitin protein ligase activity | zinc ion binding	Cul5-RING ubiquitin ligase complex | cytosol | nucleus	Acetylation | Cytoplasm | Ligase | Metal-binding | Nucleus | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		
Rhipicephalus microplus	6941	A0A6G5A0V9	Dipeptidyl peptidase 1		458	Unreviewed		proteolysis	cysteine-type peptidase activity | dipeptidyl-peptidase activity		Chloride | Disulfide bond | Hydrolase | Protease | Signal | Thiol protease		Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B
Rhipicephalus microplus	6941	A0A6G5A081	Vesicle-associated membrane protein 7		218	Unreviewed	Cytoplasmic vesicle, phagosome membrane | Cytoplasmic vesicle, secretory vesicle membrane | Endoplasmic reticulum membrane | Golgi apparatus, trans-Golgi network membrane | Late endosome membrane | Lysosome membrane	exocytosis | protein transport | vesicle fusion	SNAP receptor activity | SNARE binding	endoplasmic reticulum membrane | Golgi apparatus | late endosome membrane | lysosomal membrane | phagocytic vesicle membrane | SNARE complex | transport vesicle membrane	Coiled coil | Membrane | Protein transport | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus microplus	6941	A0A6G5A057	Ras-related protein Rab-24		199	Unreviewed	Cytoplasm, cytoskeleton, spindle | Cytoplasm, cytosol | Cytoplasm, perinuclear region | Cytoplasmic vesicle, autophagosome membrane | Membrane	autophagy | protein transport	G protein activity | GTP binding | metal ion binding	autophagosome membrane | cytoplasmic vesicle | cytosol | perinuclear region of cytoplasm | spindle	Autophagy | Cytoplasm | Cytoplasmic vesicle | Cytoskeleton | GTP-binding | Hydrolase | Lipoprotein | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Prenylation | Protein transport | Transport		The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state. RAB24 is required for the clearance of late autophagic vacuoles under basal conditions. It is not needed for starvation-induced autophagy. Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction
Rhipicephalus microplus	6941	A0A6G5A022	Ras-related protein Rab-30		217	Unreviewed	Cytoplasmic vesicle, autophagosome membrane | Golgi apparatus, cis-Golgi network | Golgi apparatus, trans-Golgi network membrane | Lysosome | Membrane		G protein activity | GTP binding | metal ion binding	autophagosome membrane | cytoplasmic vesicle | Golgi apparatus | lysosome	Cytoplasm | Cytoplasmic vesicle | Golgi apparatus | GTP-binding | Hydrolase | Lipoprotein | Lysosome | Magnesium | Membrane | Metal-binding | Methylation | Nucleotide-binding | Prenylation		The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins. Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner. Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection
Rhipicephalus microplus	6941	A0A6G5A009	DNA topoisomerase		523	Unreviewed		DNA recombination | DNA repair | DNA topological change	DNA binding | DNA topoisomerase type I (single strand cut, ATP-independent) activity | zinc ion binding	nucleus | RecQ family helicase-topoisomerase III complex	DNA-binding | Isomerase | Topoisomerase		Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand
Rhipicephalus microplus	6941	A0A6G4ZZX8	Vacuolar protein sorting-associated protein 35		875	Unreviewed	Cytoplasm | Early endosome | Late endosome | Membrane	neurotransmitter receptor transport, endosome to plasma membrane | positive regulation of gene expression | positive regulation of signal transduction | regulation of developmental process | regulation of postsynapse organization | regulation of protein catabolic process | regulation of protein localization | regulation of protein stability | regulation of transport | retrograde transport, endosome to Golgi	D1 dopamine receptor binding	cytosol | early endosome | late endosome | retromer, cargo-selective complex	Cytoplasm | Endosome | Membrane | Phosphoprotein | Protein transport | Transmembrane | Transmembrane helix | Transport		Plays a role in vesicular protein sorting
Rhipicephalus microplus	6941	A0A6G4ZZW5	Vesicle-associated membrane protein 7		219	Unreviewed	Cytoplasmic vesicle, phagosome membrane | Cytoplasmic vesicle, secretory vesicle membrane | Endoplasmic reticulum membrane | Golgi apparatus, trans-Golgi network membrane | Late endosome membrane | Lysosome membrane	exocytosis | protein transport | vesicle fusion	SNAP receptor activity | SNARE binding	endoplasmic reticulum membrane | Golgi apparatus | late endosome membrane | lysosomal membrane | phagocytic vesicle membrane | SNARE complex | transport vesicle membrane	Coiled coil | Membrane | Protein transport | Reference proteome | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus microplus	6941	A0A6G4ZZT0	HECT-type E3 ubiquitin transferase		635	Unreviewed	Nucleus	negative regulation of Notch signaling pathway | negative regulation of smoothened signaling pathway | Notch signaling pathway | proteasome-mediated ubiquitin-dependent protein catabolic process | protein ubiquitination | receptor internalization	Notch binding | ubiquitin protein ligase activity	cytoplasm | nucleus	Notch signaling pathway | Nucleus | Repeat | Transferase | Ubl conjugation | Ubl conjugation pathway		
Rhipicephalus microplus	6941	A0A6G5A6S0	Cysteine protease		167	Unreviewed	Cytoplasm	aggrephagy | autophagosome assembly | mitophagy | piecemeal microautophagy of the nucleus | protein processing | protein transport	cysteine-type endopeptidase activity | protein-phosphatidylethanolamide deconjugating activity	cytoplasm	Autophagy | Cytoplasm | Hydrolase | Protease | Protein transport | Signal | Thiol protease | Transport		Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins
Rhipicephalus microplus	6941	A0A6G4ZWW6	(3R)-3-hydroxyacyl-CoA dehydrogenase		226	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein		
Rhipicephalus microplus	6941	A0A6G4ZZ21	Exosome complex component RRP4		290	Unreviewed	Cytoplasm | Nucleus, nucleolus	CUT catabolic process | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | nuclear polyadenylation-dependent rRNA catabolic process | poly(A)-dependent snoRNA 3'-end processing | regulation of gene expression | TRAMP-dependent tRNA surveillance pathway | U4 snRNA 3'-end processing	RNA binding	cytoplasmic exosome (RNase complex) | nuclear exosome (RNase complex) | nucleolus	Cytoplasm | Exosome | Nucleus | Phosphoprotein | RNA-binding | rRNA processing		
Rhipicephalus microplus	6941	A0A6G4ZWP2	Phosphomannomutase		256	Unreviewed	Cytoplasm	GDP-mannose biosynthetic process | mannose metabolic process | protein N-linked glycosylation	metal ion binding | phosphomannomutase activity	cytosol	Cytoplasm | Isomerase | Magnesium | Metal-binding		Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions
Rhipicephalus microplus	6941	A0A4Y6GSI1	Cytochrome c oxidase subunit 1	COI	224	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A4P8YV64	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A4P8YTI9	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A4D6G1I1	Cytochrome c oxidase subunit 1		273	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A482JXN4	Cytochrome c oxidase subunit 1	COI	223	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A481U4U5	Cytochrome c oxidase subunit 1	Cox1	271	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A481U4T9	Cytochrome c oxidase subunit 1	Cox1	271	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A481U3N9	Cytochrome c oxidase subunit 1	Cox1	271	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A410GY45	Angiotensin-converting enzyme	Bm91	610	Unreviewed		proteolysis	carboxypeptidase activity | metal ion binding | metallopeptidase activity | peptidyl-dipeptidase activity	plasma membrane	Carboxypeptidase | Disulfide bond | Glycoprotein | Hydrolase | Metal-binding | Metalloprotease | Protease | Signal | Zinc		
Rhipicephalus microplus	6941	A0A3S9ST46	Cytochrome c oxidase subunit 1	COI	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A3Q9DKH6	Cytochrome c oxidase subunit 1	COX1	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A3G2CKA9	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A3G2CK40	Cytochrome c oxidase subunit 1	COI	210	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A513U4K8	Cytochrome c oxidase subunit 1	CO1	181	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A3G2CK38	Cytochrome c oxidase subunit 1	COI	216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A386HV79	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A386HV48	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A385L5B1	Cytochrome c oxidase subunit 1	COI	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A385L593	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A385L591	Cytochrome c oxidase subunit 1	COI	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A385L588	Cytochrome c oxidase subunit 1	COI	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A385L582	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A385L580	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A385L578	Cytochrome c oxidase subunit 1	COI	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A385L572	Cytochrome c oxidase subunit 1	COI	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A385L569	Cytochrome c oxidase subunit 1	COI	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6G4ZWQ5	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial		284	Unreviewed	Mitochondrion inner membrane	respiratory electron transport chain | tricarboxylic acid cycle	2 iron, 2 sulfur cluster binding | 3 iron, 4 sulfur cluster binding | 4 iron, 4 sulfur cluster binding | electron transfer activity | metal ion binding | succinate dehydrogenase (quinone) activity	mitochondrial inner membrane	2Fe-2S | 3Fe-4S | 4Fe-4S | Electron transport | Iron | Iron-sulfur | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Transport | Tricarboxylic acid cycle		Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)
Rhipicephalus microplus	6941	A0A345S555	Cytochrome c oxidase subunit 1	CO1	220	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A3G2CK36	Cytochrome c oxidase subunit 1	COI	215	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A513U4L8	Cytochrome c oxidase subunit 1	CO1	181	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A346LTZ9	Cytochrome c oxidase subunit 1	COI	197	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A5B7QGH5	Cytochrome c oxidase subunit 1	COX1	193	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A5B7QBV8	Cytochrome c oxidase subunit 1	COX1	191	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6G4ZWF8	Glyceraldehyde-3-phosphate dehydrogenase		295	Unreviewed		glucose metabolic process | glyceraldehyde-3-phosphate metabolic process | glycolytic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | NAD binding | NADP binding	cytosol	Glycolysis | NAD | Nucleotide-binding | Oxidoreductase		
Rhipicephalus microplus	6941	A0A6G4ZWE8	Adenosine kinase		348	Unreviewed	Nucleus	adenosine salvage | AMP salvage | purine nucleobase metabolic process	adenosine kinase activity | ATP binding	cytosol | nucleus	ATP-binding | Kinase | Magnesium | Nucleotide-binding | Nucleus | Purine salvage | Transferase		ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives
Rhipicephalus microplus	6941	A0A6G4ZWA6	4-hydroxyphenylpyruvate dioxygenase		280	Unreviewed	Cytoplasm | Endoplasmic reticulum membrane | Golgi apparatus membrane	L-phenylalanine catabolic process | L-tyrosine catabolic process	4-hydroxyphenylpyruvate dioxygenase activity | lactoylglutathione lyase activity | metal ion binding | protein homodimerization activity	endoplasmic reticulum membrane | Golgi membrane	Cytoplasm | Dioxygenase | Endoplasmic reticulum | Golgi apparatus | Iron | Membrane | Metal-binding | Oxidoreductase | Phenylalanine catabolism | Pyruvate | Repeat | Tyrosine catabolism		Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism
Rhipicephalus microplus	6941	A0A6G4ZW77	Isovaleryl-CoA dehydrogenase, mitochondrial		381	Unreviewed	Mitochondrion	L-leucine catabolic process	3-methylbutanoyl-CoA dehydrogenase activity | flavin adenine dinucleotide binding	mitochondrion	FAD | Flavoprotein | Mitochondrion | Oxidoreductase | Transit peptide		Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA
Rhipicephalus microplus	6941	A0A6G4ZVZ0	Dolichol-phosphate mannosyltransferase subunit 1		277	Unreviewed	Endoplasmic reticulum	dolichol-linked oligosaccharide biosynthetic process | GPI anchor biosynthetic process | protein O-linked glycosylation via mannose	dolichyl-phosphate beta-D-mannosyltransferase activity | metal ion binding	endoplasmic reticulum membrane	Endoplasmic reticulum | Glycosyltransferase | Magnesium | Manganese | Metal-binding | Transferase		Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins
Rhipicephalus microplus	6941	A0A6G4ZVW9	6-phosphofructokinase		612	Unreviewed	Cytoplasm	canonical glycolysis | fructose 1,6-bisphosphate metabolic process | fructose 6-phosphate metabolic process	6-phosphofructokinase activity | AMP binding | ATP binding | fructose-6-phosphate binding | identical protein binding | metal ion binding | monosaccharide binding	6-phosphofructokinase complex	Allosteric enzyme | ATP-binding | Cytoplasm | Glycolysis | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Signal | Transferase		Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
Rhipicephalus microplus	6941	A0A6G4ZVU9	Aminopeptidase		849	Unreviewed	Cell membrane | Membrane	peptide catabolic process | proteolysis	alanyl aminopeptidase activity | metalloaminopeptidase activity | peptide binding | zinc ion binding	cytoplasm | extracellular space | plasma membrane | side of membrane	Aminopeptidase | Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipoprotein | Membrane | Metal-binding | Metalloprotease | Protease | Signal | Signal-anchor | Transmembrane | Transmembrane helix | Zinc		
Rhipicephalus microplus	6941	A0A6G4ZVL0	glutamyl aminopeptidase		245	Unreviewed	Cell membrane | Membrane	peptide catabolic process | proteolysis	glutamyl aminopeptidase activity | metalloaminopeptidase activity | peptide binding | zinc ion binding	cytoplasm | extracellular space | plasma membrane	Aminopeptidase | Calcium | Glycoprotein | Hydrolase | Membrane | Metal-binding | Metalloprotease | Protease | Transmembrane | Transmembrane helix | Zinc		
Rhipicephalus microplus	6941	A0A6G4ZUI5	Kinesin-like protein		886	Unreviewed	Cytoplasm, cytoskeleton	anterograde axonal transport of mitochondrion | establishment or maintenance of microtubule cytoskeleton polarity | female gamete generation | nuclear migration | synaptic vesicle transport	ATP binding | microtubule binding | microtubule motor activity	axon cytoplasm | kinesin complex | microtubule	ATP-binding | Coiled coil | Cytoplasm | Cytoskeleton | Microtubule | Motor protein | Nucleotide-binding		
Rhipicephalus microplus	6941	A0A6G4ZUF8	Protein detached		708	Unreviewed	Cell membrane, sarcolemma | Cytoplasm, cytoskeleton	establishment of cell polarity | maintenance of presynaptic active zone structure | muscle cell cellular homeostasis | neuromuscular synaptic transmission | regulation of neurotransmitter secretion | regulation of short-term neuronal synaptic plasticity	actin binding | WW domain binding | zinc ion binding	cytoplasm | cytoskeleton | dystrophin-associated glycoprotein complex | neuromuscular junction | sarcolemma	Actin-binding | Calcium | Cell membrane | Coiled coil | Cytoplasm | Cytoskeleton | Membrane | Metal-binding | Zinc | Zinc-finger		
Rhipicephalus microplus	6941	A0A6C0NSM7	Cytochrome c oxidase subunit 1	COX1	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6B9SCF6	Cytochrome c oxidase subunit 1	COI	192	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6B9S9M2	Cytochrome c oxidase subunit 1	COI	176	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A6G4ZWG7	Fructose-1,6-bisphosphatase isozyme 2		338	Unreviewed	Cell junction | Cytoplasm, myofibril, sarcomere, Z line | Nucleus	fructose 1,6-bisphosphate metabolic process | fructose 6-phosphate metabolic process | fructose metabolic process | gluconeogenesis | sucrose biosynthetic process	fructose 1,6-bisphosphate 1-phosphatase activity | metal ion binding	anchoring junction | cytosol | nucleus | Z disc	Calcium | Carbohydrate metabolism | Cell junction | Cytoplasm | Hydrolase | Magnesium | Metal-binding | Nucleus | Phosphoprotein		Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate
Rhipicephalus microplus	6941	A0A5P1J1L5	Cytochrome c oxidase subunit 1	cox1	216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A648TBN8	NAD(P)H oxidase (H2O2-forming)	DuoxA	719	Unreviewed	Membrane	cuticle development | defense response to bacterium | hydrogen peroxide catabolic process | molting cycle | post-embryonic animal morphogenesis | superoxide anion generation	calcium ion binding | NAD(P)H oxidase H2O2-forming activity | peroxidase activity | superoxide-generating NAD(P)H oxidase activity	NADPH oxidase complex	Calcium | FAD | Flavoprotein | Glycoprotein | Hydrogen peroxide | Membrane | Metal-binding | NADP | Oxidoreductase | Peroxidase | Repeat | Transmembrane | Transmembrane helix		
Rhipicephalus microplus	6941	A0A5B7QGJ8	Cytochrome c oxidase subunit 1	COX1	187	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A5B7QGX9	Cytochrome c oxidase subunit 1	COX1	191	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A5B9QYT9	Cytochrome c oxidase subunit 1	COI	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A5B9QYW6	Cytochrome c oxidase subunit 1	COI	216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A5B9QYV6	Cytochrome c oxidase subunit 1	COI	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A5B9R1P0	Cytochrome c oxidase subunit 1	COI	200	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A5B9R1R5	Cytochrome c oxidase subunit 1	COI	212	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A5B9R2Y1	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A5B9R3X1	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A5B9R3Y7	Cytochrome c oxidase subunit 1	COI	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus microplus	6941	A0A5B9QYX6	Cytochrome c oxidase subunit 1	COI	199	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A9D4QDG6	Presenilin		457	Unreviewed	Endoplasmic reticulum membrane | Golgi apparatus membrane	amyloid-beta formation | calcium ion homeostasis | membrane protein ectodomain proteolysis | Notch signaling pathway | protein processing	aspartic endopeptidase activity, intramembrane cleaving	endoplasmic reticulum membrane | gamma-secretase complex | Golgi membrane	Endoplasmic reticulum | Golgi apparatus | Hydrolase | Membrane | Notch signaling pathway | Protease | Reference proteome | Transmembrane | Transmembrane helix		Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors
Rhipicephalus sanguineus	34632	A0A9D4QDB0	Copine-3		1333	Unreviewed	Cell junction, focal adhesion | Cell membrane | Cytoplasm | Nucleus	cellular response to calcium ion	ATP binding | ATP hydrolysis activity | ATP-dependent protein folding chaperone | metal ion binding | unfolded protein binding	cytoplasm | focal adhesion | nucleus | plasma membrane | protein-containing complex	ATP-binding | Calcium | Cell junction | Cell membrane | Chaperone | Cytoplasm | Membrane | Metal-binding | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Repeat | Signal | Stress response		Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation
Rhipicephalus sanguineus	34632	A0A9D4QDD9	Presenilin		502	Unreviewed	Endoplasmic reticulum membrane | Golgi apparatus membrane	amyloid-beta formation | calcium ion homeostasis | membrane protein ectodomain proteolysis | Notch signaling pathway | protein processing	aspartic endopeptidase activity, intramembrane cleaving	endoplasmic reticulum membrane | gamma-secretase complex | Golgi membrane	Endoplasmic reticulum | Golgi apparatus | Hydrolase | Membrane | Notch signaling pathway | Protease | Reference proteome | Transmembrane | Transmembrane helix		Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors
Rhipicephalus sanguineus	34632	A0A9D4QDL8	serine--tRNA ligase		498	Unreviewed	Cytoplasm	seryl-tRNA aminoacylation	ATP binding | serine-tRNA ligase activity	cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Cytoplasm | Ligase | Nucleotide-binding | Protein biosynthesis | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4QF56	tRNA-dihydrouridine synthase		321	Unreviewed			flavin adenine dinucleotide binding | tRNA-dihydrouridine20a synthase activity		Flavoprotein | FMN | Nucleotide-binding | Oxidoreductase | Reference proteome | tRNA processing		Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs
Rhipicephalus sanguineus	34632	A0A9D4QE73	Ubiquitin carboxyl-terminal hydrolase		439	Unreviewed	Nucleus	chromatin organization | protein deubiquitination | ubiquitin-dependent protein catabolic process	cysteine-type deubiquitinase activity	cytoplasm | nucleus	Chromatin regulator | Hydrolase | Nucleus | Protease | Reference proteome | Thiol protease | Ubl conjugation pathway		Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK118ub1). Mediates bisymmetric organization of the PR-DUB complex and is involved in association with nucleosomes to mediate deubiquitination. Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Polycomb group (PcG) protein
Rhipicephalus sanguineus	34632	A0A9D4QEH1	exodeoxyribonuclease III		2113	Unreviewed		base-excision repair	DNA-(apurinic or apyrimidinic site) endonuclease activity | double-stranded DNA 3'-5' DNA exonuclease activity | nucleic acid binding | phosphoric diester hydrolase activity | zinc ion binding	nucleus	Coiled coil | Hydrolase | Magnesium | Manganese | Metal-binding | Reference proteome | Zinc | Zinc-finger		
Rhipicephalus sanguineus	34632	A0A9D4QEM3	Reticulocalbin-3		544	Unreviewed	Endoplasmic reticulum lumen	asparagine metabolic process | glutamine metabolic process | oxaloacetate metabolic process | protein transport	calcium ion binding | omega-amidase activity	endoplasmic reticulum lumen | mitochondrion	Calcium | Chaperone | Endoplasmic reticulum | Glycoprotein | Hydrolase | Metal-binding | Reference proteome | Repeat | Signal		Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion
Rhipicephalus sanguineus	34632	A0A9D4QEX8	Ras-related protein Rab-14		215	Unreviewed	Cytoplasmic vesicle | Early endosome membrane | Golgi apparatus, trans-Golgi network membrane | Recycling endosome	defense response to bacterium | endocytic recycling | Golgi to endosome transport | phagosome maturation | protein transport	G protein activity | GTP binding	cytosol | early endosome membrane | phagocytic vesicle | recycling endosome | trans-Golgi network	Acetylation | Cytoplasmic vesicle | Endosome | Golgi apparatus | GTP-binding | Hydrolase | Lipoprotein | Membrane | Methylation | Nucleotide-binding | Prenylation | Protein transport | Reference proteome | Transport		
Rhipicephalus sanguineus	34632	A0A9D4QD74	UBC core domain-containing protein		323	Unreviewed	Cell membrane	ameboidal-type cell migration | cellular process involved in reproduction in multicellular organism | developmental process involved in reproduction | hemocyte migration | melanization defense response | small GTPase-mediated signal transduction	ATP binding | GTP binding | GTPase activity | transferase activity	plasma membrane	ATP-binding | Cell membrane | GTP-binding | Lipoprotein | Membrane | Methylation | Nucleotide-binding | Prenylation | Reference proteome | Transferase | Ubl conjugation pathway		
Rhipicephalus sanguineus	34632	A0A9D4QFH8	E3 ubiquitin-protein ligase TRIM71		733	Unreviewed	Cytoplasm, P-body	negative regulation of translation | proteasome-mediated ubiquitin-dependent protein catabolic process | protein polyubiquitination | regulatory ncRNA-mediated gene silencing	miRNA binding | ubiquitin protein ligase activity | zinc ion binding	P-body	Coiled coil | Cytoplasm | Developmental protein | Metal-binding | Reference proteome | Repeat | RNA-binding | RNA-mediated gene silencing | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		
Rhipicephalus sanguineus	34632	A0A9D4QDV7	Lysine-specific histone demethylase		799	Unreviewed	Chromosome | Nucleus	positive regulation of cell population proliferation | regulation of DNA-templated transcription	chromatin binding | FAD-dependent H3K4me/H3K4me3 demethylase activity | flavin adenine dinucleotide binding | RNA binding	chromosome | nucleus	Chromatin regulator | Chromosome | Coiled coil | FAD | Flavoprotein | Nucleus | Oxidoreductase | Phosphoprotein | Reference proteome | Repressor | Transcription | Transcription regulation		Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3
Rhipicephalus sanguineus	34632	A0A9D4QCV8	Acyl-coenzyme A thioesterase 13		161	Unreviewed	Cytoplasm, cytoskeleton, spindle | Cytoplasm, cytosol | Mitochondrion | Nucleus	lipid metabolic process	fatty acyl-CoA hydrolase activity	cytosol | mitochondrion | nucleus | spindle	Acetylation | Cytoplasm | Cytoskeleton | Hydrolase | Lipid metabolism | Mitochondrion | Nucleus | Reference proteome		Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis
Rhipicephalus sanguineus	34632	A0A9D4QC02	N-alpha-acetyltransferase 20		173	Unreviewed	Cytoplasm | Nucleus		protein N-terminal-methionine acetyltransferase activity	NatB complex | nucleus	Acyltransferase | Cytoplasm | Nucleus | Reference proteome | Transferase		Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration
Rhipicephalus sanguineus	34632	A0A9D4QCG5	Ubiquitin-conjugating enzyme E2 H		1790	Unreviewed	Cytoplasm, cytoskeleton		ATP binding | guanyl-nucleotide exchange factor activity | ubiquitin conjugating enzyme activity | zinc ion binding	cytoplasm | cytoskeleton	Acetylation | ATP-binding | Cytoplasm | Cytoskeleton | Guanine-nucleotide releasing factor | Metal-binding | Nucleotide-binding | Reference proteome | Transferase | Ubl conjugation | Ubl conjugation pathway | Zinc | Zinc-finger		Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A
Rhipicephalus sanguineus	34632	A0A9D4SRL0	Serine/threonine-protein kinase RIO1		533	Unreviewed	Cytoplasm	ribosome biogenesis	ATP binding | hydrolase activity | metal ion binding | protein serine/threonine kinase activity	cytoplasm	ATP-binding | Cytoplasm | Hydrolase | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Reference proteome | Ribosome biogenesis | Serine/threonine-protein kinase | Transferase		Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation
Rhipicephalus sanguineus	34632	A0A9D4QCG3	HECT-type E3 ubiquitin transferase		799	Unreviewed	Nucleus	mRNA transport | protein polyubiquitination | regulation of signal transduction | ubiquitin-dependent protein catabolic process	ubiquitin protein ligase activity	cytoplasm | nucleus	Coiled coil | mRNA transport | Nucleus | Reference proteome | Transferase | Transport | Ubl conjugation pathway		
Rhipicephalus sanguineus	34632	A0A9D4QCE4	dynamin GTPase		677	Unreviewed	Cytoplasm, cytosol | Mitochondrion outer membrane	endocytosis | intracellular distribution of mitochondria | mitochondrial fission | peroxisome fission	GTP binding | GTPase activity | lipid binding | microtubule binding	cytosol | microtubule | mitochondrial outer membrane	Cytoplasm | GTP-binding | Hydrolase | Lipid-binding | Membrane | Mitochondrion | Mitochondrion outer membrane | Nucleotide-binding | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4QC01	DNA (cytosine-5)-methyltransferase		1453	Unreviewed	Nucleus	DNA methylation-dependent constitutive heterochromatin formation | methylation | negative regulation of gene expression via chromosomal CpG island methylation	chromatin binding | DNA (cytosine-5-)-methyltransferase activity | DNA binding | zinc ion binding	nucleus	DNA-binding | Metal-binding | Methyltransferase | Nucleus | Reference proteome | Repeat | S-adenosyl-L-methionine | Transferase | Zinc | Zinc-finger		
Rhipicephalus sanguineus	34632	A0A9D4QBS8	10-formyltetrahydrofolate dehydrogenase		907	Unreviewed		10-formyltetrahydrofolate catabolic process | one-carbon metabolic process	formyltetrahydrofolate dehydrogenase activity | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	cytoplasm	NADP | One-carbon metabolism | Oxidoreductase | Phosphopantetheine | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4QBN3	O-phosphoseryl-tRNA(Sec) selenium transferase		483	Unreviewed	Cytoplasm	conversion of seryl-tRNAsec to selenocys-tRNAsec | selenocysteine incorporation	O-phosphoseryl-tRNA(Sec) selenium transferase activity | tRNA binding	cytoplasm	Cytoplasm | Protein biosynthesis | Pyridoxal phosphate | Reference proteome | RNA-binding | Selenium | Transferase | tRNA-binding		Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis
Rhipicephalus sanguineus	34632	A0A9D4QB52	Sugar phosphate phosphatase		460	Unreviewed		DNA damage response | methylation	metal ion binding | phosphatase activity | protein carboxyl O-methyltransferase activity	nucleus	Hydrolase | Manganese | Metal-binding | Methyltransferase | Nickel | Reference proteome | S-adenosyl-L-methionine | Transferase		Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response
Rhipicephalus sanguineus	34632	A0A9D4QB17	(3R)-3-hydroxyacyl-CoA dehydrogenase		258	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4QB01	Carbonic anhydrase		1121	Unreviewed		proteolysis	carbonate dehydratase activity | metalloendopeptidase activity | zinc ion binding	cytoplasm	Lyase | Membrane | Metal-binding | Reference proteome | Transmembrane | Transmembrane helix | Zinc		Reversible hydration of carbon dioxide
Rhipicephalus sanguineus	34632	A0A9D4QAY3	Phosphoinositide phospholipase C		939	Unreviewed		G protein-coupled receptor signaling pathway | lipid catabolic process | phosphatidylinositol metabolic process | phosphatidylinositol-mediated signaling | release of sequestered calcium ion into cytosol	calcium ion binding | lyase activity | phosphatidylinositol-4,5-bisphosphate phospholipase C activity	cytoplasm	Calcium | Coiled coil | Disulfide bond | Hydrolase | Lipid degradation | Lipid metabolism | Lyase | Magnesium | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4QFU6	GMP reductase		262	Unreviewed		purine nucleobase metabolic process | purine nucleotide metabolic process	GMP reductase activity | metal ion binding	GMP reductase complex	Metal-binding | NADP | Oxidoreductase | Potassium | Purine metabolism | Reference proteome		Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
Rhipicephalus sanguineus	34632	A0A9D4QAV2	DNA-directed RNA polymerase		1089	Unreviewed	Cytoplasm, cytosol | Nucleus	defense response to virus | DNA-templated transcription | innate immune response	DNA binding | DNA-directed RNA polymerase activity | metal ion binding | ribonucleoside binding	cytosol | DNA-directed RNA polymerase complex | nucleus	Antiviral defense | Cytoplasm | DNA-directed RNA polymerase | Immunity | Innate immunity | Magnesium | Metal-binding | Nucleotidyltransferase | Nucleus | Reference proteome | Transcription | Transferase | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4QCU8	tRNA-dihydrouridine synthase		321	Unreviewed			flavin adenine dinucleotide binding | tRNA-dihydrouridine20a synthase activity		Flavoprotein | FMN | Nucleotide-binding | Oxidoreductase | Reference proteome | tRNA processing		Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs
Rhipicephalus sanguineus	34632	A0A9D4QFZ4	Phosphoenolpyruvate carboxykinase [GTP]		592	Unreviewed		cellular response to glucose stimulus | gluconeogenesis | glycerol biosynthetic process from pyruvate | oxaloacetate metabolic process | propionate catabolic process | response to lipid | response to starvation	GTP binding | manganese ion binding | phosphoenolpyruvate carboxykinase (GTP) activity	cytosol	Decarboxylase | GTP-binding | Lyase | Manganese | Metal-binding | Nucleotide-binding | Reference proteome		Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle
Rhipicephalus sanguineus	34632	A0A9D4QM55	t-SNARE coiled-coil homology domain-containing protein		597	Unreviewed	Membrane	Golgi to vacuole transport | intra-Golgi vesicle-mediated transport | intracellular protein transport | macroautophagy | retrograde transport, endosome to Golgi | vesicle fusion with Golgi apparatus	SNAP receptor activity | SNARE binding	cytosol | endoplasmic reticulum membrane | ER to Golgi transport vesicle membrane | Golgi apparatus | late endosome membrane | SNARE complex	Coiled coil | Membrane | Protein transport | Reference proteome | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus sanguineus	34632	A0A9D4QG34	Phosphoacetylglucosamine mutase		484	Unreviewed		carbohydrate metabolic process | UDP-N-acetylglucosamine biosynthetic process	metal ion binding | phosphoacetylglucosamine mutase activity		Isomerase | Magnesium | Metal-binding | Phosphoprotein | Reference proteome		Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation
Rhipicephalus sanguineus	34632	A0A9D4QAS4	Isocitrate dehydrogenase [NADP]		416	Unreviewed		glyoxylate cycle | isocitrate metabolic process | NADP+ metabolic process | tricarboxylic acid cycle	isocitrate dehydrogenase (NADP+) activity | magnesium ion binding | NAD binding	cytosol | mitochondrion | peroxisome	Glyoxylate bypass | Magnesium | Manganese | Metal-binding | NADP | Oxidoreductase | Reference proteome | Tricarboxylic acid cycle		
Rhipicephalus sanguineus	34632	A0A9D4SRJ3	Thiamine-triphosphatase		663	Unreviewed	Cytoplasm	thiamine diphosphate metabolic process | thiamine metabolic process	DNA binding | magnesium ion binding | thiamine triphosphate phosphatase activity | zinc ion binding	cytoplasm	Acetylation | Coiled coil | Cytoplasm | DNA-binding | Hydrolase | Magnesium | Metal-binding | Reference proteome | Zinc | Zinc-finger		Hydrolase highly specific for thiamine triphosphate (ThTP)
Rhipicephalus sanguineus	34632	A0A9D4SR73	Protein deacetylase HDAC6		938	Unreviewed	Cell projection, axon | Cell projection, dendrite | Cytoplasm, cytoskeleton, cilium basal body | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Nucleus | Perikaryon	epigenetic regulation of gene expression | mitochondrion localization | negative regulation of cellular component organization | regulation of microtubule-based process | response to stress	actin binding | histone deacetylase activity, hydrolytic mechanism | transferase activity | zinc ion binding	axon | centrosome | dendrite | histone deacetylase complex | perikaryon	Actin-binding | Cell projection | Chromatin regulator | Cytoplasm | Cytoskeleton | Hydrolase | Metal-binding | Methylation | Nucleus | Phosphoprotein | Reference proteome | Repeat | Repressor | Transcription | Transcription regulation | Transferase | Ubl conjugation | Ubl conjugation pathway | Zinc | Zinc-finger		
Rhipicephalus sanguineus	34632	A0A9D4SQW2	Inositol-tetrakisphosphate 1-kinase		343	Unreviewed		inositol trisphosphate metabolic process	ATP binding | inositol-1,3,4-trisphosphate 5-kinase activity | inositol-1,3,4-trisphosphate 6-kinase activity | inositol-3,4,5,6-tetrakisphosphate 1-kinase activity | magnesium ion binding	cytoplasm	ATP-binding | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Reference proteome | Transferase		Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3
Rhipicephalus sanguineus	34632	A0A9D4SQH0	protein acetyllysine N-acetyltransferase		445	Unreviewed		DNA repair-dependent chromatin remodeling | regulation of gene expression	histone H3K18 deacetylase activity, NAD-dependent | metal ion binding | NAD+ binding	chromatin | nucleus | site of double-strand break	Metal-binding | NAD | Phosphoprotein | Reference proteome | Transferase | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4SP93	S-methyl-5'-thioadenosine phosphorylase		278	Unreviewed	Cytoplasm | Nucleus	L-methionine salvage from methylthioadenosine | purine ribonucleoside salvage	S-methyl-5-thioadenosine phosphorylase activity	cytosol | nucleus	Cytoplasm | Glycosyltransferase | Nucleus | Purine salvage | Reference proteome | Transferase		Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates
Rhipicephalus sanguineus	34632	A0A9D4SNT3	Coatomer subunit alpha		1615	Unreviewed	Cytoplasmic vesicle, COPI-coated vesicle membrane | Golgi apparatus membrane	endoplasmic reticulum to Golgi vesicle-mediated transport | intra-Golgi vesicle-mediated transport | intracellular protein transport | regulation of DNA-templated transcription | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	sequence-specific DNA binding | structural molecule activity | zinc ion binding	COPI vesicle coat | Golgi membrane	Cytoplasm | ER-Golgi transport | Golgi apparatus | Membrane | Metal-binding | Nucleus | Protein transport | Reference proteome | Repeat | Transcription | Transcription regulation | Transport | WD repeat | Zinc | Zinc-finger		The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors
Rhipicephalus sanguineus	34632	A0A9D4SNS4	E3 ubiquitin-protein ligase Topors		729	Unreviewed	Golgi apparatus, cis-Golgi network	Golgi vesicle transport | protein monoubiquitination | protein polyubiquitination	ubiquitin protein ligase activity | zinc ion binding	Golgi apparatus | TRAPP complex	Metal-binding | Reference proteome | Transcription | Transcription regulation | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		
Rhipicephalus sanguineus	34632	A0A9D4SNA5	Histone-lysine N-methyltransferase, H3 lysine-79 specific		1717	Unreviewed	Nucleus	DNA damage checkpoint signaling | DNA repair | methylation	histone H3K79 trimethyltransferase activity	histone methyltransferase complex	Chromatin regulator | Coiled coil | Methyltransferase | Nucleus | Reference proteome | S-adenosyl-L-methionine | Transferase		Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone
Rhipicephalus sanguineus	34632	A0A9D4SN89	dual-specificity kinase		421	Unreviewed		actin cytoskeleton organization	ATP binding | metal ion binding | protein serine/threonine kinase activity | protein serine/threonine/tyrosine kinase activity | protein tyrosine kinase activity	cytoplasm | nucleus	ATP-binding | Kinase | Magnesium | Manganese | Metal-binding | Nucleotide-binding | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase | Tyrosine-protein kinase		
Rhipicephalus sanguineus	34632	A0A9D4SN80	Serine/threonine-protein kinase PLK		570	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Nucleus	mitotic spindle organization	ATP binding | protein serine/threonine kinase activity	centrosome | cytoplasm | kinetochore | nucleus | spindle pole	ATP-binding | Cytoplasm | Cytoskeleton | Kinase | Nucleotide-binding | Nucleus | Reference proteome | Repeat | Serine/threonine-protein kinase | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4SN61	Tyrosine-protein kinase receptor		793	Unreviewed	Membrane	cell surface receptor protein tyrosine kinase signaling pathway	ATP binding | transmembrane receptor protein tyrosine kinase activity | Wnt-protein binding	plasma membrane | receptor complex	ATP-binding | Disulfide bond | Kinase | Kringle | Membrane | Nucleotide-binding | Phosphoprotein | Receptor | Reference proteome | Transferase | Transmembrane | Transmembrane helix | Tyrosine-protein kinase		
Rhipicephalus sanguineus	34632	A0A9D4SN08	non-specific serine/threonine protein kinase		5143	Unreviewed	Cytoplasm, myofibril, sarcomere	anatomical structure morphogenesis | cell differentiation | positive regulation of locomotion | positive regulation of sarcomere organization | positive regulation of striated muscle contraction	ATP binding | calmodulin binding | metal ion binding | protein serine/threonine kinase activity	A band	ATP-binding | Calcium | Calmodulin-binding | Cytoplasm | Disulfide bond | Immunoglobulin domain | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Reference proteome | Repeat | Serine/threonine-protein kinase | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4SMN4	Protein kinase domain-containing protein		300	Unreviewed	Nucleus	cell division | G2/M transition of mitotic cell cycle | mitotic G2 DNA damage checkpoint signaling | positive regulation of cell cycle process | positive regulation of meiotic cell cycle	ATP binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	nucleus	ATP-binding | Cell cycle | Cell division | Kinase | Mitosis | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4SMH9	Probable ATP-dependent RNA helicase DDX46		1090	Unreviewed	Nucleus speckle	mRNA splicing, via spliceosome	ATP binding | hydrolase activity | nucleic acid binding | RNA helicase activity	nuclear speck | spliceosomal complex	ATP-binding | Coiled coil | Helicase | Hydrolase | mRNA processing | mRNA splicing | Nucleotide-binding | Nucleus | Reference proteome | Spliceosome		Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site
Rhipicephalus sanguineus	34632	A0A9D4SM66	Damage-control phosphatase ARMT1		953	Unreviewed		DNA damage response | methylation	ATP hydrolysis activity | metal ion binding | methyltransferase activity | phosphatase activity	nucleus	Hydrolase | Manganese | Metal-binding | Methyltransferase | Nickel | Reference proteome | S-adenosyl-L-methionine | Transferase		Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response
Rhipicephalus sanguineus	34632	A0A9D4QHT3	Target of rapamycin complex 2 subunit MAPKAP1		499	Unreviewed	Cell membrane | Cytoplasm, perinuclear region | Early endosome membrane | Endoplasmic reticulum membrane | Golgi apparatus membrane | Late endosome membrane | Lysosome membrane | Mitochondrion outer membrane | Nucleus	TORC2 signaling	phosphatidylinositol-4,5-bisphosphate binding	early endosome membrane | endoplasmic reticulum membrane | Golgi membrane | late endosome membrane | lysosomal membrane | mitochondrial outer membrane | nucleus | perinuclear region of cytoplasm | plasma membrane | TORC2 complex	Cell membrane | Cytoplasm | Endoplasmic reticulum | Endosome | Golgi apparatus | Lysosome | Membrane | Mitochondrion | Mitochondrion outer membrane | Nucleus | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4QHF8	Protein kinase domain-containing protein		304	Unreviewed		G1/S transition of mitotic cell cycle | regulation of G2/M transition of mitotic cell cycle | signal transduction	ATP binding | cyclin binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	cyclin-dependent protein kinase holoenzyme complex | cytoplasm | nucleus	ATP-binding | Kinase | Nucleotide-binding | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4QHC4	Fibroblast growth factor receptor		790	Unreviewed	Membrane	positive regulation of cell population proliferation	ATP binding | fibroblast growth factor receptor activity	plasma membrane | receptor complex	ATP-binding | Disulfide bond | Glycoprotein | Immunoglobulin domain | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Receptor | Reference proteome | Repeat | Signal | Transferase | Transmembrane | Transmembrane helix | Tyrosine-protein kinase		Receptor for basic fibroblast growth factor
Rhipicephalus sanguineus	34632	A0A9D4QH07	Phosphotransferase		406	Unreviewed		glucose metabolic process | glycolytic process | intracellular glucose homeostasis	ATP binding | D-glucose binding | fructokinase activity | glucokinase activity	cytosol | mitochondrion	ATP-binding | Glycolysis | Kinase | Nucleotide-binding | Reference proteome | Transferase		Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate
Rhipicephalus sanguineus	34632	A0A9D4QH03	Phosphoenolpyruvate carboxykinase [GTP]		560	Unreviewed		cellular response to glucose stimulus | gluconeogenesis | glycerol biosynthetic process from pyruvate | oxaloacetate metabolic process | propionate catabolic process | response to lipid | response to starvation	GTP binding | manganese ion binding | phosphoenolpyruvate carboxykinase (GTP) activity	cytosol	Decarboxylase | GTP-binding | Lyase | Manganese | Metal-binding | Nucleotide-binding | Reference proteome		Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle
Rhipicephalus sanguineus	34632	A0A9D4QGZ5	Alanine--tRNA ligase		1000	Unreviewed		alanyl-tRNA aminoacylation	alanine-tRNA ligase activity | aminoacyl-tRNA deacylase activity | ATP binding | tRNA binding | zinc ion binding	mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Coiled coil | Cytoplasm | Ligase | Metal-binding | Nucleotide-binding | Protein biosynthesis | Reference proteome | RNA-binding | tRNA-binding | Zinc		Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain
Rhipicephalus sanguineus	34632	A0A9D4QGV5	Aminopeptidase		799	Unreviewed	Cell membrane | Cytoplasm	peptide catabolic process | proteolysis	alanyl aminopeptidase activity | metalloaminopeptidase activity | peptide binding | zinc ion binding	cytoplasm | extracellular space | plasma membrane	Aminopeptidase | Cytoplasm | Hydrolase | Metal-binding | Metalloprotease | Protease | Reference proteome | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4QGR2	Cadherin-related family member 1		1613	Unreviewed	Cell membrane	adherens junction organization | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | cell migration | cell morphogenesis | cell-cell adhesion mediated by cadherin | cell-cell junction assembly | epithelium development | establishment or maintenance of cell polarity | homophilic cell adhesion via plasma membrane adhesion molecules	beta-catenin binding | cadherin binding | calcium ion binding	adherens junction | catenin complex	Calcium | Cell adhesion | Cell membrane | Glycoprotein | Membrane | Receptor | Reference proteome | Repeat | Signal | Transmembrane | Transmembrane helix		Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells
Rhipicephalus sanguineus	34632	A0A9D4QGM5	oxoglutarate dehydrogenase (succinyl-transferring)		841	Unreviewed	Mitochondrion | Nucleus	glycolytic process | tricarboxylic acid cycle	DNA binding | metal ion binding | oxoglutarate dehydrogenase (succinyl-transferring) activity | thiamine pyrophosphate binding	mitochondrion | nucleus | oxoglutarate dehydrogenase complex	Glycolysis | Magnesium | Metal-binding | Mitochondrion | Oxidoreductase | Reference proteome | Thiamine pyrophosphate | Transit peptide		
Rhipicephalus sanguineus	34632	A0A9D4QGC2	Elongation of very long chain fatty acids protein		309	Unreviewed	Membrane	fatty acid elongation, monounsaturated fatty acid | fatty acid elongation, polyunsaturated fatty acid | fatty acid elongation, saturated fatty acid | sphingolipid biosynthetic process | very long-chain fatty acid biosynthetic process	fatty acid elongase activity	endoplasmic reticulum membrane	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Membrane | Reference proteome | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4QG91	DNA topoisomerase 2		1471	Unreviewed	Nucleus	DNA topological change | resolution of meiotic recombination intermediates | sister chromatid segregation	ATP binding | DNA binding | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | metal ion binding	nucleus	ATP-binding | DNA-binding | Isomerase | Magnesium | Metal-binding | Nucleotide-binding | Nucleus | Reference proteome | Topoisomerase		Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks
Rhipicephalus sanguineus	34632	A0A9D4QFZ7	Methionine aminopeptidase		385	Unreviewed	Cytoplasm	proteolysis	initiator methionyl aminopeptidase activity | metalloaminopeptidase activity | zinc ion binding	cytosol	Aminopeptidase | Cytoplasm | Hydrolase | Metal-binding | Protease | Reference proteome | Zinc | Zinc-finger		Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)
Rhipicephalus sanguineus	34632	A0A9D4QAG4	DNA replication licensing factor MCM5		693	Unreviewed	Nucleus	DNA replication initiation | double-strand break repair via break-induced replication	3'-5' DNA helicase activity | ATP binding | DNA replication origin binding | hydrolase activity | single-stranded DNA binding | single-stranded DNA helicase activity	MCM complex | nucleus	ATP-binding | Cell cycle | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Reference proteome		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Rhipicephalus sanguineus	34632	A0A9D4PUR1	DNA repair protein RAD50		1305	Unreviewed	Chromosome | Nucleus	chromosome organization involved in meiotic cell cycle | double-strand break repair | telomere maintenance via recombination | telomere maintenance via telomerase	ATP binding | ATP hydrolysis activity | double-stranded telomeric DNA binding | G-quadruplex DNA binding | metal ion binding | single-stranded telomeric DNA binding	condensed nuclear chromosome | Mre11 complex	ATP-binding | Chromosome | Coiled coil | DNA damage | DNA repair | Hydrolase | Magnesium | Meiosis | Metal-binding | Nucleotide-binding | Nucleus | Reference proteome | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4QAE3	cysteine--tRNA ligase		549	Unreviewed		cysteinyl-tRNA aminoacylation	ATP binding | cysteine-tRNA ligase activity | metal ion binding	cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Metal-binding | Nucleotide-binding | Protein biosynthesis | Reference proteome | Zinc		In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants
Rhipicephalus sanguineus	34632	A0A9D4Q1C8	E3 ubiquitin-protein ligase		1694	Unreviewed	Nucleus, nucleoplasm	DNA repair | proteasome-mediated ubiquitin-dependent protein catabolic process | protein polyubiquitination | regulation of signal transduction	ubiquitin protein ligase activity | zinc ion binding	nuclear speck	DNA damage | DNA repair | Nucleus | Phosphoprotein | Reference proteome | Transferase | Ubl conjugation pathway		
Rhipicephalus sanguineus	34632	A0A9D4Q183	cyclin-dependent kinase		234	Unreviewed		G1/S transition of mitotic cell cycle | regulation of G2/M transition of mitotic cell cycle | regulation of gene expression | signal transduction	ATP binding | cyclin binding | cyclin-dependent protein serine/threonine kinase activity	cyclin-dependent protein kinase holoenzyme complex | cytoplasm | nucleus	ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Serine/threonine-protein kinase | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4Q154	(3R)-3-hydroxyacyl-CoA dehydrogenase		254	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4Q103	NAD(P)H oxidase (H2O2-forming)		1090	Unreviewed	Apical cell membrane	anatomical structure morphogenesis | defense response to bacterium | hydrogen peroxide catabolic process | response to oxidative stress | superoxide anion generation	calcium ion binding | heme binding | NAD(P)H oxidase H2O2-forming activity | peroxidase activity | superoxide-generating NAD(P)H oxidase activity	apical plasma membrane | NADPH oxidase complex	Calcium | FAD | Flavoprotein | Hydrogen peroxide | Membrane | Metal-binding | NADP | Oxidoreductase | Peroxidase | Reference proteome | Repeat | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4Q0U9	(3R)-3-hydroxyacyl-CoA dehydrogenase		252	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4Q0T2	DNA replication licensing factor MCM7	MCM7	661	Unreviewed	Chromosome | Nucleus	DNA replication initiation | DNA strand elongation involved in DNA replication | double-strand break repair via break-induced replication	ATP binding | hydrolase activity | single-stranded DNA binding | single-stranded DNA helicase activity	chromosome | MCM complex | nucleus	ATP-binding | Cell cycle | Chromosome | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Reference proteome | Ubl conjugation		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Rhipicephalus sanguineus	34632	A0A9D4Q015	DNA-directed RNA polymerase subunit		1676	Unreviewed	Chromosome | Cytoplasm | Nucleus	transcription by RNA polymerase II	DNA binding | DNA-directed RNA polymerase activity | hydrolase activity | metal ion binding	chromosome | cytoplasm | RNA polymerase II, core complex	Acetylation | Chromosome | Cytoplasm | DNA-binding | DNA-directed RNA polymerase | Hydrolase | Isopeptide bond | Magnesium | Metal-binding | Methylation | Nucleotidyltransferase | Nucleus | Phosphoprotein | Reference proteome | Repeat | Transcription | Transferase | Ubl conjugation | Zinc		DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Rhipicephalus sanguineus	34632	A0A9D4Q008	Phosphomannomutase		253	Unreviewed	Cytoplasm	GDP-mannose biosynthetic process | mannose metabolic process | protein N-linked glycosylation	metal ion binding | phosphomannomutase activity	cytosol	Cytoplasm | Isomerase | Magnesium | Metal-binding | Reference proteome		Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions
Rhipicephalus sanguineus	34632	A0A9D4PZU6	Ras-related C3 botulinum toxin substrate 1		202	Unreviewed		actin filament bundle assembly | dorsal appendage formation | hemocyte migration | JNK cascade | lamellipodium assembly | melanotic encapsulation of foreign target | mesodermal cell migration | myoblast fusion | phagocytosis, engulfment | positive regulation of wound healing | regulation of adherens junction organization | regulation of axonogenesis | small GTPase-mediated signal transduction | tracheal outgrowth, open tracheal system	GTP binding | GTPase activity | protein kinase binding		GTP-binding | Lipoprotein | Methylation | Nucleotide-binding | Phagocytosis | Prenylation | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PZJ7	(3R)-3-hydroxyacyl-CoA dehydrogenase		255	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PZG7	Serine/threonine-protein kinase RIO2		537	Unreviewed	Cytoplasm	maturation of SSU-rRNA	ATP binding | metal ion binding | protein serine/threonine kinase activity	cytosol | nucleus | preribosome, small subunit precursor	ATP-binding | Cytoplasm | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Reference proteome | Ribosome biogenesis | Serine/threonine-protein kinase | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4PZA0	(3R)-3-hydroxyacyl-CoA dehydrogenase		209	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PZ89	Cytosine-specific methyltransferase		1303	Unreviewed	Nucleus	DNA methylation-dependent constitutive heterochromatin formation | methylation | negative regulation of gene expression via chromosomal CpG island methylation	chromatin binding | DNA (cytosine-5-)-methyltransferase activity | DNA binding | zinc ion binding	nucleus	DNA-binding | Metal-binding | Methyltransferase | Nucleus | Reference proteome | Repeat | S-adenosyl-L-methionine | Transferase | Zinc | Zinc-finger		
Rhipicephalus sanguineus	34632	A0A9D4PYM5	Dolichol-phosphate mannosyltransferase subunit 1		213	Unreviewed	Endoplasmic reticulum	dolichol-linked oligosaccharide biosynthetic process | GPI anchor biosynthetic process | protein O-linked glycosylation via mannose	dolichyl-phosphate beta-D-mannosyltransferase activity | metal ion binding	endoplasmic reticulum membrane	Endoplasmic reticulum | Glycosyltransferase | Magnesium | Manganese | Metal-binding | Reference proteome | Transferase		Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins
Rhipicephalus sanguineus	34632	A0A9D4PYF5	Bifunctional coenzyme A synthase		496	Unreviewed	Cytoplasm | Mitochondrion matrix	coenzyme A biosynthetic process	ATP binding | dephospho-CoA kinase activity | pantetheine-phosphate adenylyltransferase activity	mitochondrial matrix	ATP-binding | Cytoplasm | Kinase | Mitochondrion | Multifunctional enzyme | Nucleotide-binding | Nucleotidyltransferase | Phosphoprotein | Reference proteome | Transferase		Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation
Rhipicephalus sanguineus	34632	A0A9D4PYF2	(3R)-3-hydroxyacyl-CoA dehydrogenase		248	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PY89	(3R)-3-hydroxyacyl-CoA dehydrogenase		248	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PY74	alpha-amylase		730	Unreviewed	Nucleus	carbohydrate metabolic process | regulation of DNA-templated transcription	alpha-amylase activity | DNA binding | metal ion binding | protein dimerization activity	nucleus	Calcium | Chloride | DNA-binding | Metal-binding | Nucleus | Reference proteome | Transcription | Transcription regulation		
Rhipicephalus sanguineus	34632	A0A9D4PY33	(3R)-3-hydroxyacyl-CoA dehydrogenase		248	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PXG4	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase		1104	Unreviewed	Cytoplasm	innate immune response | NAD+ catabolic process | negative regulation of MyD88-independent toll-like receptor signaling pathway | response to axon injury | signal transduction	NAD+ nucleosidase activity | NAD+ nucleosidase activity, cyclic ADP-ribose generating | signaling adaptor activity	cell body | cytoplasm | dendrite	Cytoplasm | Hydrolase | Immunity | Innate immunity | NAD | Reference proteome | Repeat		
Rhipicephalus sanguineus	34632	A0A9D4PWZ7	Bifunctional glutamate/proline--tRNA ligase		1519	Unreviewed		glutamyl-tRNA aminoacylation | prolyl-tRNA aminoacylation	ATP binding | glutamate-tRNA ligase activity | metal ion binding | proline-tRNA ligase activity | RNA binding	aminoacyl-tRNA synthetase multienzyme complex | cytoplasm	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Metal-binding | Multifunctional enzyme | Nucleotide-binding | Phosphoprotein | Protein biosynthesis | Reference proteome | RNA-binding | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4PW41	3-hydroxyanthranilate 3,4-dioxygenase		354	Unreviewed	Cytoplasm	'de novo' NAD+ biosynthetic process from L-tryptophan | anthranilate metabolic process | L-tryptophan catabolic process | quinolinate biosynthetic process	3-hydroxyanthranilate 3,4-dioxygenase activity | ferrous iron binding	cytoplasm	Cytoplasm | Dioxygenase | Iron | Metal-binding | Oxidoreductase | Pyridine nucleotide biosynthesis | Reference proteome		Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate
Rhipicephalus sanguineus	34632	A0A9D4PVU3	Tyrosine-protein kinase receptor		307	Unreviewed	Membrane	cell differentiation | cell surface receptor protein tyrosine kinase signaling pathway | cellular response to nerve growth factor stimulus | nervous system development | positive regulation of neuron projection development | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ATP binding | metal ion binding | neurotrophin binding | neurotrophin receptor activity | transmembrane receptor protein tyrosine kinase activity	axon | plasma membrane | receptor complex	ATP-binding | Developmental protein | Differentiation | Glycoprotein | Kinase | Leucine-rich repeat | Magnesium | Membrane | Metal-binding | Neurogenesis | Nucleotide-binding | Phosphoprotein | Receptor | Reference proteome | Repeat | Signal | Transferase | Transmembrane | Transmembrane helix | Tyrosine-protein kinase		
Rhipicephalus sanguineus	34632	A0A9D4PVG5	Phosphatidylserine decarboxylase proenzyme, mitochondrial		440	Unreviewed	Mitochondrion inner membrane	phosphatidylethanolamine biosynthetic process | protein autoprocessing	phosphatidylserine decarboxylase activity	mitochondrial inner membrane	Decarboxylase | Lipid biosynthesis | Lipid metabolism | Lyase | Membrane | Mitochondrion | Mitochondrion inner membrane | Phospholipid biosynthesis | Phospholipid metabolism | Pyruvate | Reference proteome | Transmembrane | Transmembrane helix | Zymogen		Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane
Rhipicephalus sanguineus	34632	A0A9D4PVF0	GP-PDE domain-containing protein		298	Unreviewed	Membrane	glycerophospholipid catabolic process	lyase activity | metal ion binding | phosphatidylcholine lysophospholipase activity | phosphoric diester hydrolase activity	endoplasmic reticulum membrane	Disulfide bond | Hydrolase | Lipid metabolism | Lyase | Magnesium | Membrane | Metal-binding | Reference proteome | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4PV44	DNA 3'-5' helicase		1488	Unreviewed	Nucleus	double-strand break repair via homologous recombination	3'-5' DNA helicase activity | ATP binding | DNA binding | four-way junction helicase activity | GTP binding | GTPase activity | metal ion binding	chromosome | cytoplasm | nucleus	ATP-binding | DNA-binding | GTP-binding | Helicase | Hydrolase | Isomerase | Metal-binding | Nucleotide-binding | Nucleus | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4SRV7	4-hydroxyphenylpyruvate dioxygenase		384	Unreviewed	Cytoplasm | Endoplasmic reticulum membrane | Golgi apparatus membrane	L-phenylalanine catabolic process | L-tyrosine catabolic process	4-hydroxyphenylpyruvate dioxygenase activity | metal ion binding | protein homodimerization activity	endoplasmic reticulum membrane | Golgi membrane	Cytoplasm | Dioxygenase | Endoplasmic reticulum | Golgi apparatus | Iron | Membrane | Metal-binding | Oxidoreductase | Phenylalanine catabolism | Reference proteome | Repeat | Tyrosine catabolism		Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism
Rhipicephalus sanguineus	34632	A0A9D4Q1R9	Histone deacetylase		943	Unreviewed	Nucleus	epigenetic regulation of gene expression | negative regulation of transcription by RNA polymerase II	histone deacetylase activity, hydrolytic mechanism | metal ion binding	histone deacetylase complex	Chromatin regulator | Hydrolase | Metal-binding | Nucleus | Reference proteome | Repressor | Transcription | Transcription regulation | Zinc		Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events
Rhipicephalus sanguineus	34632	A0A9D4Q1T3	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase		379	Unreviewed	Endoplasmic reticulum membrane	fatty acid elongation | sphingolipid biosynthetic process | very long-chain fatty acid biosynthetic process	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	endoplasmic reticulum membrane	Coiled coil | Endoplasmic reticulum | Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Lyase | Membrane | Reference proteome | Transmembrane | Transmembrane helix		Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators
Rhipicephalus sanguineus	34632	A0A9D4Q1U8	Nuclear pore complex protein		897	Unreviewed	Chromosome, centromere, kinetochore | Nucleus, nuclear pore complex | Nucleus membrane	mRNA export from nucleus | post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery | protein import into nucleus	structural constituent of nuclear pore	kinetochore | nuclear membrane | nuclear pore outer ring	Acetylation | Centromere | Chromosome | Kinetochore | Membrane | Methylation | mRNA transport | Nuclear pore complex | Nucleus | Phosphoprotein | Protein transport | Reference proteome | Translocation | Transport		Functions as a component of the nuclear pore complex (NPC)
Rhipicephalus sanguineus	34632	A0A9D4Q2F6	dolichyl-phosphate-mannose--protein mannosyltransferase		594	Unreviewed	Endoplasmic reticulum | Membrane	endoplasmic reticulum unfolded protein response	dolichyl-phosphate-mannose-protein mannosyltransferase activity	endoplasmic reticulum | membrane	Endoplasmic reticulum | Membrane | Reference proteome | Repeat | TPR repeat | Transferase | Transmembrane | Transmembrane helix		Transfers mannosyl residues to the hydroxyl group of serine or threonine residues
Rhipicephalus sanguineus	34632	A0A9D4QAD7	AP-2 complex subunit sigma		198	Unreviewed	Cell membrane | Membrane, coated pit	clathrin-dependent endocytosis | intracellular protein transport	clathrin adaptor activity	AP-2 adaptor complex	Cell membrane | Coated pit | Endocytosis | Membrane | Protein transport | Reference proteome | Transport		
Rhipicephalus sanguineus	34632	A0A9D4QAA9	Glycine N-methyltransferase		253	Unreviewed	Cytoplasm	methylation | one-carbon metabolic process | protein homotetramerization | regulation of gluconeogenesis | S-adenosylhomocysteine metabolic process | S-adenosylmethionine metabolic process | sarcosine metabolic process	folic acid binding | glycine binding | glycine N-methyltransferase activity | identical protein binding | S-adenosyl-L-methionine binding	cytosol	Cytoplasm | Folate-binding | Methyltransferase | Phosphoprotein | Reference proteome | S-adenosyl-L-methionine | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4Q9U7	Oxaloacetate tautomerase FAHD1, mitochondrial		219	Unreviewed		carboxylic acid metabolic process	acetylpyruvate hydrolase activity | acylpyruvate hydrolase activity | metal ion binding | oxaloacetate decarboxylase activity | oxaloacetate tautomerase activity	mitochondrion	Metal-binding | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4Q9R0	Uridine diphosphate glucose pyrophosphatase NUDT14		2534	Unreviewed	Cytoplasm | Nucleus	double-strand break repair via synthesis-dependent strand annealing | interstrand cross-link repair	3'-5' DNA helicase activity | ATP binding | four-way junction DNA binding | four-way junction helicase activity | metal ion binding | nuclease activity | UDP-sugar diphosphatase activity	cytoplasm | nucleus	ATP-binding | Coiled coil | Cytoplasm | Helicase | Hydrolase | Magnesium | Nucleotide-binding | Nucleus | Reference proteome		Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose
Rhipicephalus sanguineus	34632	A0A9D4Q9E1	Presenilin		503	Unreviewed	Endoplasmic reticulum membrane | Golgi apparatus membrane	amyloid-beta formation | calcium ion homeostasis | membrane protein ectodomain proteolysis | Notch signaling pathway | protein processing	aspartic endopeptidase activity, intramembrane cleaving	endoplasmic reticulum membrane | gamma-secretase complex | Golgi membrane	Endoplasmic reticulum | Golgi apparatus | Hydrolase | Membrane | Notch signaling pathway | Protease | Reference proteome | Transmembrane | Transmembrane helix		Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors
Rhipicephalus sanguineus	34632	A0A9D4Q9C4	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase		340	Unreviewed	Golgi apparatus membrane	carbohydrate metabolic process | chondroitin sulfate proteoglycan biosynthetic process	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity | metal ion binding	Golgi membrane	Glycoprotein | Golgi apparatus | Manganese | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4Q8Y4	Phosphoglycerate kinase		378	Unreviewed		gluconeogenesis | glycolytic process	ADP binding | ATP binding | metal ion binding | phosphoglycerate kinase activity	cytosol	ATP-binding | Glycolysis | Kinase | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Reference proteome | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4Q8W5	SH3 domain-containing protein		2863	Unreviewed	Cytoplasm, cytoskeleton	actin filament capping | axon midline choice point recognition | long-term strengthening of neuromuscular junction | maintenance of presynaptic active zone structure | negative regulation of microtubule depolymerization	actin binding | microtubule binding	cytoskeleton | fusome | lateral plasma membrane | neuromuscular junction | spectrosome	Actin capping | Actin-binding | Coiled coil | Cytoplasm | Cytoskeleton | Phosphoprotein | Reference proteome | Repeat | SH3 domain		
Rhipicephalus sanguineus	34632	A0A9D4Q8S6	Acireductone dioxygenase		185	Unreviewed	Cell membrane | Cytoplasm | Nucleus	L-methionine salvage from methylthioadenosine	acireductone dioxygenase (Ni2+-requiring) activity | acireductone dioxygenase [iron(II)-requiring] activity | iron ion binding | nickel cation binding	cytoplasm | nucleus | plasma membrane	Amino-acid biosynthesis | Cytoplasm | Dioxygenase | Iron | Metal-binding | Methionine biosynthesis | Nickel | Nucleus | Oxidoreductase | Reference proteome		Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Rhipicephalus sanguineus	34632	A0A9D4Q8L9	ubiquitinyl hydrolase 1		554	Unreviewed	Mitochondrion inner membrane | Nucleus	protein deubiquitination | protein transport | proteolysis	cysteine-type deubiquitinase activity	mitochondrial inner membrane | nucleus	Hydrolase | Membrane | Mitochondrion | Mitochondrion inner membrane | Nucleus | Protease | Protein transport | Reference proteome | Thiol protease | Transcription | Transcription regulation | Transit peptide | Translocation | Transmembrane | Transmembrane helix | Transport | Ubl conjugation pathway		Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane
Rhipicephalus sanguineus	34632	A0A9D4Q8B7	alpha-glucosidase		572	Unreviewed		carbohydrate metabolic process | L-alanine import across plasma membrane | L-leucine import across plasma membrane | phenylalanine transport	alpha-1,4-glucosidase activity | aromatic amino acid transmembrane transporter activity | L-alanine transmembrane transporter activity | L-leucine transmembrane transporter activity	apical plasma membrane | basolateral plasma membrane	Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4Q7E2	Glucosamine-6-phosphate isomerase		283	Unreviewed	Cytoplasm	carbohydrate metabolic process | glucosamine catabolic process | N-acetylglucosamine catabolic process | N-acetylneuraminate catabolic process	glucosamine-6-phosphate deaminase activity | identical protein binding	cytoplasm	Carbohydrate metabolism | Cytoplasm | Hydrolase | Reference proteome		Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway
Rhipicephalus sanguineus	34632	A0A9D4Q7B4	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial		922	Unreviewed	Mitochondrion inner membrane	respiratory electron transport chain | tricarboxylic acid cycle	2 iron, 2 sulfur cluster binding | 3 iron, 4 sulfur cluster binding | 4 iron, 4 sulfur cluster binding | ATP binding | electron transfer activity | hydrolase activity | metal ion binding | nucleic acid binding | RNA helicase activity | succinate dehydrogenase (quinone) activity	mitochondrial inner membrane	2Fe-2S | 3Fe-4S | 4Fe-4S | ATP-binding | Electron transport | Helicase | Hydrolase | Iron | Iron-sulfur | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Nucleotide-binding | Oxidoreductase | Reference proteome | Transport | Tricarboxylic acid cycle		Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)
Rhipicephalus sanguineus	34632	A0A9D4QAG1	Mitochondrial basic amino acids transporter		276	Unreviewed	Mitochondrion inner membrane	mitochondrial L-ornithine transmembrane transport	high-affinity L-arginine transmembrane transporter activity	mitochondrial inner membrane	Amino-acid transport | Membrane | Mitochondrion | Mitochondrion inner membrane | Reference proteome | Repeat | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus sanguineus	34632	A0A9D4Q751	Flavin-containing monooxygenase		476	Unreviewed	Endoplasmic reticulum membrane		flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Membrane | Monooxygenase | NADP | Oxidoreductase | Reference proteome | Transmembrane | Transmembrane helix		Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine
Rhipicephalus sanguineus	34632	A0A9D4Q6L9	Adenylate kinase		252	Unreviewed	Cytoplasm, cytosol | Mitochondrion intermembrane space	ADP biosynthetic process | AMP metabolic process | ATP metabolic process	AMP kinase activity | ATP binding	cytosol | mitochondrial intermembrane space	ATP-binding | Cytoplasm | Kinase | Mitochondrion | Nucleotide-binding | Reference proteome | Transferase		Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways
Rhipicephalus sanguineus	34632	A0A9D4Q6H8	Elongation of very long chain fatty acids protein		284	Unreviewed	Membrane	fatty acid elongation, monounsaturated fatty acid | fatty acid elongation, polyunsaturated fatty acid | fatty acid elongation, saturated fatty acid | sphingolipid biosynthetic process | very long-chain fatty acid biosynthetic process	fatty acid elongase activity	endoplasmic reticulum membrane	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Membrane | Reference proteome | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4Q6F7	Survival of motor neuron-related-splicing factor 30		284	Unreviewed	Nucleus speckle | Nucleus, Cajal body	mRNA processing | regulation of alternative mRNA splicing, via spliceosome | RNA splicing	RNA binding	Cajal body | cytoplasm | nuclear speck | precatalytic spliceosome	Coiled coil | mRNA processing | mRNA splicing | Nucleus | Reference proteome | Spliceosome		Involved in spliceosome assembly
Rhipicephalus sanguineus	34632	A0A9D4Q5X1	Vesicle transport v-SNARE N-terminal domain-containing protein		227	Unreviewed	Endomembrane system	Golgi to vacuole transport | intra-Golgi vesicle-mediated transport | intracellular protein transport | macroautophagy | regulation of protein localization to plasma membrane | retrograde transport, endosome to Golgi | vesicle fusion with Golgi apparatus	SNAP receptor activity | SNARE binding	cytosol | endoplasmic reticulum membrane | ER to Golgi transport vesicle membrane | Golgi apparatus | late endosome membrane | SNARE complex	Coiled coil | Membrane | Protein transport | Reference proteome | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus sanguineus	34632	A0A9D4Q5J6	RNA cytidine acetyltransferase		1487	Unreviewed	Nucleus, nucleolus	proteolysis | rRNA acetylation involved in maturation of SSU-rRNA | tRNA acetylation	18S rRNA cytidine N-acetyltransferase activity | ATP binding | serine-type endopeptidase activity | tRNA binding	90S preribosome | nucleolus	Acyltransferase | ATP-binding | Disulfide bond | Membrane | Nucleotide-binding | Nucleus | Reference proteome | rRNA processing | Transferase | Transmembrane | Transmembrane helix | tRNA processing		RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation
Rhipicephalus sanguineus	34632	A0A9D4Q5D6	dual-specificity kinase		401	Unreviewed	Nucleus	regulation of RNA splicing	ATP binding | protein serine/threonine kinase activity | protein serine/threonine/tyrosine kinase activity | protein tyrosine kinase activity	nucleus	ATP-binding | Kinase | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase | Tyrosine-protein kinase		
Rhipicephalus sanguineus	34632	A0A9D4Q552	Ras-related protein Rab-30		208	Unreviewed	Cytoplasmic vesicle, autophagosome membrane | Golgi apparatus, cis-Golgi network | Golgi apparatus, trans-Golgi network membrane | Lysosome | Membrane		G protein activity | GTP binding | metal ion binding	autophagosome membrane | cytoplasmic vesicle | Golgi apparatus | lysosome	Cytoplasm | Cytoplasmic vesicle | Golgi apparatus | GTP-binding | Hydrolase | Lipoprotein | Lysosome | Magnesium | Membrane | Metal-binding | Methylation | Nucleotide-binding | Prenylation | Reference proteome		The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins. Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner. Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection
Rhipicephalus sanguineus	34632	A0A9D4Q535	alpha-1,2-Mannosidase		943	Unreviewed	Endoplasmic reticulum	carbohydrate metabolic process | endoplasmic reticulum mannose trimming | translation	calcium ion binding | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | structural constituent of ribosome	cytosolic ribosome | endoplasmic reticulum quality control compartment | membrane | ribonucleoprotein complex	Calcium | Endoplasmic reticulum | Glycoprotein | Glycosidase | Hydrolase | Metal-binding | Reference proteome | Ribonucleoprotein | Ribosomal protein		
Rhipicephalus sanguineus	34632	A0A9D4Q4H0	Tryptophan 2,3-dioxygenase		415	Unreviewed		L-tryptophan catabolic process to acetyl-CoA | L-tryptophan catabolic process to kynurenine	heme binding | L-tryptophan 2,3-dioxygenase activity | metal ion binding		Dioxygenase | Heme | Iron | Metal-binding | Oxidoreductase | Reference proteome | Tryptophan catabolism		Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety
Rhipicephalus sanguineus	34632	A0A9D4Q3N4	ATP-dependent DNA helicase II subunit 2		666	Unreviewed	Nucleus	DNA recombination | double-strand break repair via nonhomologous end joining | telomere maintenance	ATP binding | damaged DNA binding | DNA helicase activity | double-stranded DNA binding | hydrolase activity | telomeric DNA binding	Ku70:Ku80 complex	ATP-binding | DNA damage | DNA recombination | DNA repair | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Reference proteome		Single-stranded DNA-dependent ATP-dependent helicase
Rhipicephalus sanguineus	34632	A0A9D4Q3G1	Glucosylceramidase		563	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Reference proteome | Signal | Sphingolipid metabolism		
Rhipicephalus sanguineus	34632	A0A9D4Q359	receptor protein-tyrosine kinase		529	Unreviewed	Membrane	glucose homeostasis | positive regulation of MAPK cascade | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ATP binding | insulin receptor activity | insulin receptor substrate binding	axon | insulin receptor complex	ATP-binding | Glycoprotein | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Receptor | Reference proteome | Repeat | Signal | Transferase | Transmembrane | Transmembrane helix | Tyrosine-protein kinase		
Rhipicephalus sanguineus	34632	A0A9D4Q2S7	(3R)-3-hydroxyacyl-CoA dehydrogenase		249	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4Q6V8	non-specific serine/threonine protein kinase		1177	Unreviewed	Nucleus		ATP binding | protein serine/threonine kinase activity | protein tyrosine kinase activity	cytoplasm | nucleoplasm	ATP-binding | Isopeptide bond | Kinase | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Signal | Transcription | Transcription regulation | Transferase | Ubl conjugation		
Rhipicephalus sanguineus	34632	A0A9D4SS00	Katanin p60 ATPase-containing subunit A1	KATNA1	369	Unreviewed	Cytoplasm, cytoskeleton | Cytoplasm | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Cytoplasm, cytoskeleton, spindle pole | Cytoplasm, cytoskeleton, spindle	cell division | microtubule severing	ATP binding | ATP hydrolysis activity | microtubule binding | microtubule severing ATPase activity	centrosome | cytoplasm | microtubule | spindle pole	ATP-binding | Cell cycle | Cell division | Cytoplasm | Cytoskeleton | Isomerase | Microtubule | Mitosis | Nucleotide-binding | Reference proteome		Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation
Rhipicephalus sanguineus	34632	A0A146HTJ7	glycerophosphodiester phosphodiesterase	GlpQ	149	Unreviewed		glycerol metabolic process | lipid metabolic process	glycerophosphodiester phosphodiesterase activity | lyase activity | metal ion binding		Disulfide bond | Glycerol metabolism | Hydrolase | Lyase | Magnesium | Metal-binding | Signal		
Rhipicephalus sanguineus	34632	A0A9D4ST39	Eukaryotic translation initiation factor 3 subunit B		704	Unreviewed	Cytoplasm	formation of cytoplasmic translation initiation complex	RNA binding | translation initiation factor activity | translation initiation factor binding	eukaryotic 43S preinitiation complex | eukaryotic 48S preinitiation complex | eukaryotic translation initiation factor 3 complex	Coiled coil | Cytoplasm | Initiation factor | Protein biosynthesis | Reference proteome | RNA-binding | WD repeat		Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome
Rhipicephalus sanguineus	34632	A0A9D4YQQ8	Dual specificity protein phosphatase		229	Unreviewed		negative regulation of MAPK cascade	MAP kinase phosphatase activity | protein serine/threonine phosphatase activity | protein tyrosine phosphatase activity | protein tyrosine/serine/threonine phosphatase activity	cytoplasm	Hydrolase | Protein phosphatase | Reference proteome		Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate
Rhipicephalus sanguineus	34632	A0A9D4YQN1	Guanylate cyclase		1022	Unreviewed	Cell membrane	intracellular signal transduction | receptor guanylyl cyclase signaling pathway	adenylate cyclase activity | ATP binding | GTP binding | guanylate cyclase activity | peptide receptor activity | protein kinase activity	plasma membrane	Cell membrane | cGMP biosynthesis | Coiled coil | Glycoprotein | GTP-binding | Lyase | Membrane | Nucleotide-binding | Receptor | Reference proteome | Signal | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4TE95	Sulfide:quinone oxidoreductase, mitochondrial		591	Unreviewed	Mitochondrion	sulfide oxidation, using sulfide:quinone oxidoreductase	FAD binding | glutathione-dependent sulfide quinone oxidoreductase activity | quinone binding | sulfide:quinone oxidoreductase activity	mitochondrion	FAD | Flavoprotein | Mitochondrion | Oxidoreductase | Quinone | Reference proteome | Transit peptide		Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione
Rhipicephalus sanguineus	34632	A0A9D4TDK9	Cadherin Y-type LIR-motif domain-containing protein		176	Unreviewed	Membrane	adherens junction organization | animal organ morphogenesis | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | cell migration | cell morphogenesis | cell-cell adhesion mediated by cadherin | cell-cell junction assembly | homophilic cell adhesion via plasma membrane adhesion molecules	beta-catenin binding | cadherin binding | calcium ion binding	adherens junction | catenin complex	Calcium | Membrane | Reference proteome | Repeat | Signal | Transmembrane | Transmembrane helix		Cadherins are calcium-dependent cell adhesion proteins
Rhipicephalus sanguineus	34632	A0A9D4TDJ3	General transcription and DNA repair factor IIH helicase subunit XPD		833	Unreviewed	Nucleus	hair cell differentiation | nucleotide-excision repair | positive regulation of mitotic recombination | transcription by RNA polymerase II	4 iron, 4 sulfur cluster binding | 5'-3' DNA helicase activity | ATP binding | damaged DNA binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | metal ion binding	nucleus	4Fe-4S | ATP-binding | Coiled coil | DNA damage | DNA repair | DNA-binding | Helicase | Hydrolase | Iron | Iron-sulfur | Isomerase | Metal-binding | Nucleotide-binding | Nucleus | Reference proteome | Transcription | Transcription regulation		
Rhipicephalus sanguineus	34632	A0A9D4TD88	Molybdopterin synthase sulfur carrier subunit		88	Unreviewed	Cytoplasm	Mo-molybdopterin cofactor biosynthetic process	molybdopterin synthase activity | nucleotide binding	molybdopterin adenylyltransferase complex | molybdopterin synthase complex	Cytoplasm | Molybdenum cofactor biosynthesis | Nucleotide-binding | Phosphoprotein | Reference proteome | Signal		Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin
Rhipicephalus sanguineus	34632	A0A9D4TBN4	Purine nucleoside phosphorylase		296	Unreviewed		nucleoside metabolic process	purine-nucleoside phosphorylase activity	cytoplasm	Coiled coil | Glycosyltransferase | Reference proteome | Transferase		The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Rhipicephalus sanguineus	34632	A0A9D4TB64	Neutral ceramidase		821	Unreviewed		ceramide catabolic process | long-chain fatty acid biosynthetic process | sphingosine biosynthetic process	metal ion binding | N-acylsphingosine amidohydrolase activity	extracellular region | membrane	Hydrolase | Lipid metabolism | Metal-binding | Reference proteome | Sphingolipid metabolism | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4TB47	non-specific serine/threonine protein kinase		227	Unreviewed	Nucleus	tRNA processing | tRNA threonylcarbamoyladenosine metabolic process	ATP binding | hydrolase activity | protein serine/threonine kinase activity	cytosol | EKC/KEOPS complex | nucleus	ATP-binding | Hydrolase | Kinase | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase | tRNA processing		Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation
Rhipicephalus sanguineus	34632	A0A9D4TAE0	cholesterol 7-desaturase		439	Unreviewed	Membrane	cholesterol metabolic process	2 iron, 2 sulfur cluster binding | cholesterol 7-desaturase [NAD(P)H] activity | metal ion binding	cytoplasm | membrane	2Fe-2S | Iron | Iron-sulfur | Membrane | Metal-binding | Oxidoreductase | Reference proteome | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4TA23	protein acetyllysine N-acetyltransferase		705	Unreviewed	Nucleus		histone deacetylase activity, NAD-dependent | metal ion binding | NAD+ binding | p53 binding | transcription corepressor activity	nuclear inner membrane | nucleoplasm | rDNA heterochromatin	Metal-binding | NAD | Nucleus | Reference proteome | Transferase | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4T9S3	Pre-mRNA-processing factor 19		495	Unreviewed	Nucleus, nucleoplasm	DNA repair | mRNA splicing, via spliceosome | protein K63-linked ubiquitination	ubiquitin protein ligase activity	cytoplasm | nucleoplasm | Prp19 complex | U2-type catalytic step 1 spliceosome	DNA damage | DNA repair | mRNA processing | mRNA splicing | Nucleus | Reference proteome | Repeat | Spliceosome | Transferase | Ubl conjugation pathway | WD repeat		Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome
Rhipicephalus sanguineus	34632	A0A9D4T9J0	KIND domain-containing protein		154	Unreviewed	Cell membrane | Cytoplasm, cytoskeleton | Cytoplasmic vesicle membrane	actin filament network formation | actin filament polymerization | actin nucleation | cleavage furrow formation | establishment of meiotic spindle localization | Golgi vesicle transport | polar body extrusion after meiotic divisions | protein transport	actin binding | microtubule binding	cell cortex | cytoplasmic vesicle membrane | cytoskeleton | plasma membrane	Actin-binding | Cell membrane | Cytoplasm | Cytoplasmic vesicle | Cytoskeleton | Membrane | Protein transport | Reference proteome | Repeat | Transport		
Rhipicephalus sanguineus	34632	A0A9D4T9G2	Nuclear hormone receptor E75		624	Unreviewed	Cytoplasm | Nucleus	cell differentiation | ecdysis, chitin-based cuticle | hormone-mediated signaling pathway | negative regulation of transcription by RNA polymerase II | positive regulation of transcription by RNA polymerase II | regulation of ecdysteroid metabolic process | response to ecdysone	heme binding | nuclear receptor activity | RNA polymerase II cis-regulatory region sequence-specific DNA binding | zinc ion binding	cytoplasm | nucleus	DNA-binding | Metal-binding | Nucleus | Receptor | Reference proteome | Transcription | Transcription regulation | Zinc | Zinc-finger		
Rhipicephalus sanguineus	34632	A0A9D4T9A4	Ion transport domain-containing protein		1123	Unreviewed	Membrane	calcium ion import across plasma membrane | calcium-mediated signaling | chemical synaptic transmission | detection of abiotic stimulus | detection of external stimulus | detection of stimulus involved in sensory perception | epithelial fluid transport | neuron remodeling	high voltage-gated calcium channel activity | metal ion binding	basolateral plasma membrane | synapse | voltage-gated calcium channel complex	Calcium | Calcium channel | Calcium transport | Glycoprotein | Ion channel | Ion transport | Membrane | Metal-binding | Reference proteome | Repeat | Transmembrane | Transmembrane helix | Transport | Voltage-gated channel		
Rhipicephalus sanguineus	34632	A0A9D4T8S2	Histone deacetylase		394	Unreviewed	Chromosome | Cytoplasm | Nucleus	heterochromatin formation	histone deacetylase activity, hydrolytic mechanism | metal ion binding	chromosome | cytoplasm | nucleus	Chromatin regulator | Chromosome | Cytoplasm | Hydrolase | Metal-binding | Nucleus | Reference proteome | Repressor | Transcription | Transcription regulation		
Rhipicephalus sanguineus	34632	A0A9D4T8I5	Dihydropteridine reductase		216	Unreviewed		L-phenylalanine catabolic process | tetrahydrobiopterin biosynthetic process	6,7-dihydropteridine reductase activity | NADH binding | NADPH binding	cytoplasm	NADP | Oxidoreductase | Reference proteome | Tetrahydrobiopterin biosynthesis		Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin
Rhipicephalus sanguineus	34632	A0A9D4T898	Alanine--tRNA ligase		859	Unreviewed		alanyl-tRNA aminoacylation	alanine-tRNA ligase activity | aminoacyl-tRNA deacylase activity | ATP binding | tRNA binding | zinc ion binding	mitochondrion	Aminoacyl-tRNA synthetase | ATP-binding | Ligase | Metal-binding | Nucleotide-binding | Protein biosynthesis | Reference proteome | RNA-binding | tRNA-binding | Zinc		Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain
Rhipicephalus sanguineus	34632	A0A9D4T7Y9	dTCF		577	Unreviewed	Nucleus	canonical Wnt signaling pathway | mesodermal cell fate determination | negative regulation of DNA-templated transcription | positive regulation of gene expression | regulation of stem cell proliferation | salivary gland morphogenesis | spiracle morphogenesis, open tracheal system	DNA-binding transcription factor activity, RNA polymerase II-specific | kinase binding | RNA polymerase II cis-regulatory region sequence-specific DNA binding | transcription corepressor binding	beta-catenin-TCF complex | chromatin	Activator | DNA-binding | Nucleus | Reference proteome | Transcription | Transcription regulation | Wnt signaling pathway		Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes
Rhipicephalus sanguineus	34632	A0A9D4T7Q4	Phosphotransferase		478	Unreviewed		glucose metabolic process | glycolytic process | intracellular glucose homeostasis	ATP binding | D-glucose binding | fructokinase activity | glucokinase activity	cytosol | mitochondrion	ATP-binding | Glycolysis | Kinase | Nucleotide-binding | Reference proteome | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4T7P5	Coatomer subunit gamma		876	Unreviewed	Cytoplasm | Golgi apparatus membrane | Cytoplasmic vesicle, COPI-coated vesicle membrane	endoplasmic reticulum to Golgi vesicle-mediated transport | intra-Golgi vesicle-mediated transport | intracellular protein transport | organelle transport along microtubule | protein secretion	structural molecule activity	COPI vesicle coat | endoplasmic reticulum | endoplasmic reticulum-Golgi intermediate compartment | Golgi membrane	Cytoplasm | Cytoplasmic vesicle | ER-Golgi transport | Golgi apparatus | Membrane | Protein transport | Reference proteome | Repeat | Transport		The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins
Rhipicephalus sanguineus	34632	A0A9D4T718	non-specific serine/threonine protein kinase		1121	Unreviewed	Cell membrane	magnesium ion homeostasis | monoatomic ion transport	protein serine/threonine kinase activity | transmembrane transporter activity	plasma membrane	CBS domain | Cell membrane | Coiled coil | Ion transport | Kinase | Membrane | Reference proteome | Repeat | Serine/threonine-protein kinase | Transferase | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus sanguineus	34632	A0A9D4T6N7	Ubiquitin-conjugating enzyme E2 C		179	Unreviewed		cell division	ATP binding | ubiquitin conjugating enzyme activity		ATP-binding | Cell cycle | Cell division | Mitosis | Nucleotide-binding | Reference proteome | Transferase | Ubl conjugation | Ubl conjugation pathway		Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit
Rhipicephalus sanguineus	34632	A0A9D4T6B7	Ubiquitin-like modifier-activating enzyme ATG7		584	Unreviewed	Cytoplasm | Preautophagosomal structure	autophagosome assembly | autophagy of mitochondrion | cellular response to nitrogen starvation | piecemeal microautophagy of the nucleus | protein modification by small protein conjugation | protein transport	Atg12 activating enzyme activity | Atg8 activating enzyme activity	phagophore assembly site	Autophagy | Cytoplasm | Protein transport | Reference proteome | Transport | Ubl conjugation pathway		E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy
Rhipicephalus sanguineus	34632	A0A9D4T5X5	DNA-directed RNA polymerase III subunit RPC2		1211	Unreviewed	Cytoplasm, cytosol | Nucleus	defense response to virus | innate immune response | transcription by RNA polymerase III	DNA binding | DNA-directed RNA polymerase activity | metal ion binding | ribonucleoside binding	cytosol | DNA-directed RNA polymerase complex | nucleus	Antiviral defense | Cytoplasm | DNA-directed RNA polymerase | Immunity | Innate immunity | Magnesium | Metal-binding | Nucleotidyltransferase | Nucleus | Reference proteome | Transcription | Transferase | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4T5U5	Signal recognition particle subunit SRP54		884	Unreviewed	Cytoplasm | Endoplasmic reticulum | Nucleus speckle	DNA repair | SRP-dependent cotranslational protein targeting to membrane, translocation	7S RNA binding | DNA binding | endoplasmic reticulum signal peptide binding | GTP binding | GTPase activity | nuclease activity	cytosol | endoplasmic reticulum | nuclear speck | signal recognition particle, endoplasmic reticulum targeting	Cytoplasm | Endoplasmic reticulum | GTP-binding | Hydrolase | Nucleotide-binding | Nucleus | Reference proteome | Ribonucleoprotein | RNA-binding | Signal recognition particle		
Rhipicephalus sanguineus	34632	A0A9D4T5N4	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase		430	Unreviewed	Golgi apparatus membrane	oligosaccharide biosynthetic process | protein N-linked glycosylation	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity | metal ion binding	Golgi membrane | Golgi stack	Disulfide bond | Glycoprotein | Glycosyltransferase | Golgi apparatus | Manganese | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4YQW7	SNF-related serine/threonine-protein kinase		750	Unreviewed	Nucleus	intracellular signal transduction	ATP binding | metal ion binding | protein serine/threonine kinase activity	cytoplasm | nucleus	ATP-binding | Kinase | Magnesium | Metal-binding | Methylation | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis
Rhipicephalus sanguineus	34632	A0A9D4YR00	Pyridoxal kinase		302	Unreviewed		pyridoxal 5'-phosphate salvage	ATP binding | pyridoxal kinase activity	cytosol	ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4YR90	Ras-related protein Rab-24		254	Unreviewed	Cytoplasm, cytoskeleton, spindle | Cytoplasm, cytosol | Cytoplasm, perinuclear region | Cytoplasmic vesicle, autophagosome membrane | Membrane	autophagy | protein transport	G protein activity | GTP binding | metal ion binding	autophagosome membrane | cytoplasmic vesicle | cytosol | perinuclear region of cytoplasm | spindle	Autophagy | Cytoplasm | Cytoplasmic vesicle | Cytoskeleton | GTP-binding | Hydrolase | Lipoprotein | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Prenylation | Protein transport | Reference proteome | Transport		The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state. RAB24 is required for the clearance of late autophagic vacuoles under basal conditions. It is not needed for starvation-induced autophagy. Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction
Rhipicephalus sanguineus	34632	A0A9D4YRJ2	RNA cytidine acetyltransferase		825	Unreviewed	Nucleus, nucleolus	rRNA acetylation involved in maturation of SSU-rRNA | tRNA acetylation	18S rRNA cytidine N-acetyltransferase activity | ATP binding | tRNA binding	90S preribosome | nucleolus	Acyltransferase | ATP-binding | Nucleotide-binding | Nucleus | Reference proteome | rRNA processing | Transferase | tRNA processing		RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation
Rhipicephalus sanguineus	34632	A0A9D4PUG2	Kinesin-like protein unc-104		1877	Unreviewed	Cytoplasm, cytoskeleton	anterograde synaptic vesicle transport | developmental maturation | positive regulation of protein transport | regulation of locomotion | regulation of nervous system development | regulation of neuron projection development | regulation of synaptic assembly at neuromuscular junction | vesicle-mediated transport	ATP binding | microtubule binding | microtubule motor activity	axon cytoplasm | dendrite | microtubule | presynapse	ATP-binding | Coiled coil | Cytoplasm | Cytoskeleton | Microtubule | Motor protein | Nucleotide-binding | Reference proteome		Required for presynaptic maturation, has a role in axonal transport of dense-core vesicles carrying synaptic vesicle precursors, components required for the morphological transformation of axonal growth cones to mature boutons
Rhipicephalus sanguineus	34632	A0A146HTI1	glycerophosphodiester phosphodiesterase	GlpQ	160	Unreviewed		glycerol metabolic process | lipid metabolic process	glycerophosphodiester phosphodiesterase activity | lyase activity | metal ion binding		Disulfide bond | Glycerol metabolism | Hydrolase | Lyase | Magnesium | Metal-binding | Signal		
Rhipicephalus sanguineus	34632	A0A140GE59	Cytochrome c oxidase subunit 1		281	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A0C5PNS0	60S acidic ribosomal protein P0		314	Unreviewed		cytoplasmic translation | ribosomal large subunit assembly	large ribosomal subunit rRNA binding | structural constituent of ribosome	cytosolic large ribosomal subunit	Phosphoprotein | Ribonucleoprotein | Ribosomal protein		Ribosomal protein P0 is the functional equivalent of E.coli protein L10
Rhipicephalus sanguineus	34632	A0A068LGB8	Metalloprotease 1		395	Unreviewed		membrane protein ectodomain proteolysis	metal ion binding | metalloendopeptidase activity		Hydrolase | Metal-binding | Metalloprotease | Protease | Signal | Zinc		
Rhipicephalus sanguineus	34632	A0A068LER5	Metalloprotease 5		506	Unreviewed		membrane protein ectodomain proteolysis	metal ion binding | metalloendopeptidase activity		Hydrolase | Metal-binding | Metalloprotease | Protease | Signal | Zinc		
Rhipicephalus sanguineus	34632	A0A068LE96	Metalloprotease 2		493	Unreviewed		membrane protein ectodomain proteolysis	metal ion binding | metalloendopeptidase activity		Hydrolase | Metal-binding | Metalloprotease | Protease | Signal | Zinc		
Rhipicephalus sanguineus	34632	X2C7G2	Cytochrome c oxidase subunit 1	cox1	267	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	X2C5X5	Cytochrome c oxidase subunit 1	cox1	267	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	X2C5G3	Cytochrome c oxidase subunit 1	cox1	267	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	X2C518	Cytochrome c oxidase subunit 1	cox1	267	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	X2C516	Cytochrome c oxidase subunit 1	cox1	267	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	X2C514	Cytochrome c oxidase subunit 1	cox1	267	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A9D4T5K6	AAA+ ATPase domain-containing protein		1433	Unreviewed	Cytoplasm, cytoskeleton	cell maturation | centrosome localization | establishment of spindle localization | maintenance of location | organelle transport along microtubule | retrograde axonal transport	ATP binding | dynein intermediate chain binding | dynein light intermediate chain binding	axon cytoplasm | axonemal dynein complex | cell cortex | endomembrane system | kinetochore | microtubule	ATP-binding | Coiled coil | Cytoplasm | Cytoskeleton | Dynein | Microtubule | Motor protein | Nucleotide-binding | Reference proteome | Repeat		
Rhipicephalus sanguineus	34632	X2C513	Cytochrome c oxidase subunit 1	cox1	267	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	V5J2Z5	Cytochrome c oxidase subunit 1	COI	235	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	U5YH30	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	U5MYE5	Cytochrome c oxidase subunit 1	COX1	229	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	U5MYB7	Cytochrome c oxidase subunit 1	COX1	228	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	R4IKS1	Cytochrome c oxidase subunit 1	cox1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	Q9MCZ1	Cytochrome c oxidase subunit 1	COI	264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	Q6WSQ2	Calreticulin		411	Unreviewed	Endoplasmic reticulum lumen	ERAD pathway | protein folding	calcium ion binding | carbohydrate binding | unfolded protein binding	endoplasmic reticulum lumen | endoplasmic reticulum membrane	Calcium | Chaperone | Disulfide bond | Endoplasmic reticulum | Lectin | Metal-binding | Repeat | Signal | Zinc		Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER
Rhipicephalus sanguineus	34632	Q64K72	Calreticulin		411	Unreviewed	Endoplasmic reticulum lumen	ERAD pathway | protein folding	calcium ion binding | carbohydrate binding | unfolded protein binding	endoplasmic reticulum lumen | endoplasmic reticulum membrane	Calcium | Chaperone | Disulfide bond | Endoplasmic reticulum | Lectin | Metal-binding | Repeat | Signal | Zinc		Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER
Rhipicephalus sanguineus	34632	M1T190	Cytochrome c oxidase subunit 1		157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	M1SUU9	Cytochrome c oxidase subunit 1		157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	G3FSX0	Cytochrome c oxidase subunit 1	COI	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	C9W1T9	Ragulator complex protein LAMTOR1		141	Unreviewed	Late endosome membrane | Lysosome membrane	cellular response to amino acid stimulus | cholesterol homeostasis | endosomal transport | lysosome organization | positive regulation of MAPK cascade | positive regulation of TOR signaling | regulation of receptor recycling	guanyl-nucleotide exchange factor activity | molecular adaptor activity	late endosome membrane | lysosomal membrane | membrane raft | Ragulator complex	Endosome | Lipoprotein | Lysosome | Membrane | Myristate | Palmitate		
Rhipicephalus sanguineus	34632	A0A9D4YRK6	RB1-inducible coiled-coil protein 1		196	Unreviewed	Cytoplasm, cytosol | Lysosome | Nucleus | Preautophagosomal structure	autophagosome assembly | autophagy of mitochondrion | glycophagy | negative regulation of cell population proliferation | piecemeal microautophagy of the nucleus | reticulophagy | ribophagy	molecular adaptor activity | protein kinase binding	Atg1/ULK1 kinase complex | cytosol | lysosome | nucleus | organelle membrane | phagophore assembly site membrane	Autophagy | Cell cycle | Coiled coil | Cytoplasm | Lysosome | Nucleus | Phosphoprotein | Reference proteome | Transcription | Transcription regulation		Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis
Rhipicephalus sanguineus	34632	X2C2Q8	Cytochrome c oxidase subunit 1	cox1	267	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A9D4T5G1	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase		396	Unreviewed	Golgi apparatus membrane	oligosaccharide biosynthetic process | protein N-linked glycosylation	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity | metal ion binding	Golgi membrane | Golgi stack	Disulfide bond | Glycoprotein | Glycosyltransferase | Golgi apparatus | Manganese | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4T599	Mitogen-activated protein kinase		373	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Cytoplasm, cytoskeleton, spindle	apoptotic process	ATP binding | MAP kinase activity	centrosome | spindle	Apoptosis | ATP-binding | Cell cycle | Cytoplasm | Cytoskeleton | Kinase | Magnesium | Nucleotide-binding | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4T4X7	Uncharacterized protein		181	Unreviewed		establishment of synaptic specificity at neuromuscular junction | gamma-aminobutyric acid receptor clustering | glycine receptor clustering | Mo-molybdopterin cofactor biosynthetic process | postsynaptic neurotransmitter receptor diffusion trapping	ATP binding | metal ion binding | molybdopterin adenylyltransferase activity | molybdopterin molybdotransferase activity	cytosol | dendrite | postsynaptic specialization membrane	ATP-binding | Magnesium | Metal-binding | Molybdenum | Molybdenum cofactor biosynthesis | Multifunctional enzyme | Nucleotide-binding | Reference proteome | Transferase		Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released
Rhipicephalus sanguineus	34632	A0A9D4SZR8	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase		364	Unreviewed	Endoplasmic reticulum membrane | Membrane	fatty acid elongation | sphingolipid biosynthetic process | very long-chain fatty acid biosynthetic process	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Lyase | Membrane | Reference proteome | Transmembrane | Transmembrane helix		Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators
Rhipicephalus sanguineus	34632	A0A9D4SZI1	Amine oxidase		583	Unreviewed	Mitochondrion outer membrane		flavin adenine dinucleotide binding | monoamine oxidase activity | primary methylamine oxidase activity	mitochondrial outer membrane	FAD | Flavoprotein | Membrane | Oxidoreductase | Reference proteome | Transmembrane | Transmembrane helix		Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine
Rhipicephalus sanguineus	34632	A0A9D4SZH4	Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial		420	Unreviewed	Mitochondrion	glutaminyl-tRNAGln biosynthesis via transamidation | mitochondrial translation	ATP binding | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	glutamyl-tRNA(Gln) amidotransferase complex | mitochondrion	ATP-binding | Ligase | Mitochondrion | Nucleotide-binding | Protein biosynthesis | Reference proteome		Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
Rhipicephalus sanguineus	34632	A0A9D4SZC7	Damage-control phosphatase ARMT1		859	Unreviewed		DNA damage response | methylation	metal ion binding | methyltransferase activity | phosphatase activity	nucleus	Hydrolase | Manganese | Metal-binding | Methyltransferase | Nickel | Reference proteome | S-adenosyl-L-methionine | Transferase		Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response
Rhipicephalus sanguineus	34632	A0A9D4SZ88	CCR4-NOT transcription complex subunit 4		602	Unreviewed	Cytoplasm | Nucleus	protein ubiquitination	RNA binding | ubiquitin protein ligase activity | zinc ion binding	CCR4-NOT complex | cytosol | nucleus	Coiled coil | Cytoplasm | Metal-binding | Methylation | Nucleus | Phosphoprotein | Reference proteome | RNA-binding | Transferase | Ubl conjugation | Ubl conjugation pathway | Zinc | Zinc-finger		Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy
Rhipicephalus sanguineus	34632	A0A9D4SYK2	NADPH--cytochrome P450 reductase		684	Unreviewed	Endoplasmic reticulum membrane	response to hormone	flavin adenine dinucleotide binding | FMN binding | NADP binding | NADPH-hemoprotein reductase activity	cytosol | endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | FMN | Membrane | NADP | Oxidoreductase | Reference proteome | Transmembrane | Transmembrane helix		This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5
Rhipicephalus sanguineus	34632	A0A9D4SYF6	Non-specific serine/threonine protein kinase		1092	Unreviewed	Nucleus	autophagosome assembly | autophagy of mitochondrion | axon extension | piecemeal microautophagy of the nucleus | positive regulation of autophagy | response to starvation | reticulophagy	ATP binding | DNA binding | protein serine/threonine kinase activity	autophagosome | cytosol | nucleus | phagophore assembly site membrane	ATP-binding | DNA-binding | Kinase | Nucleotide-binding | Nucleus | Reference proteome | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4SXT4	DNA topoisomerase 2		1760	Unreviewed		DNA topological change | resolution of meiotic recombination intermediates | sister chromatid segregation	ATP binding | DNA binding | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | metal ion binding	nucleus	ATP-binding | DNA-binding | Isomerase | Magnesium | Metal-binding | Nucleotide-binding | Reference proteome | Topoisomerase		Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks
Rhipicephalus sanguineus	34632	A0A9D4SXP0	Molybdopterin synthase sulfur carrier subunit		88	Unreviewed	Cytoplasm	Mo-molybdopterin cofactor biosynthetic process	molybdopterin synthase activity | nucleotide binding	molybdopterin adenylyltransferase complex | molybdopterin synthase complex	Cytoplasm | Molybdenum cofactor biosynthesis | Nucleotide-binding | Phosphoprotein | Reference proteome		Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin
Rhipicephalus sanguineus	34632	A0A9D4SX83	Peptidase metallopeptidase domain-containing protein		472	Unreviewed		collagen catabolic process | extracellular matrix organization | proteolysis	metalloendopeptidase activity | zinc ion binding	extracellular matrix | extracellular space	Calcium | Hydrolase | Metal-binding | Metalloprotease | Protease | Reference proteome | Repeat | Signal | Zinc | Zymogen		
Rhipicephalus sanguineus	34632	A0A9D4SWS3	Unconventional myosin-Va		2221	Unreviewed		actin filament organization | animal organ development | system development | tissue development	actin filament binding | ATP binding | microfilament motor activity	cytoplasm | membrane | myosin complex	Actin-binding | ATP-binding | Calmodulin-binding | Coiled coil | Motor protein | Myosin | Nucleotide-binding | Reference proteome | Repeat		
Rhipicephalus sanguineus	34632	A0A9D4SWN5	RNA helicase		463	Unreviewed	Cytoplasm, P-body	negative regulation of translation | P-body assembly	ATP binding | hydrolase activity | RNA binding | RNA helicase activity	P-body	ATP-binding | Cytoplasm | Helicase | Hydrolase | Nucleotide-binding | Reference proteome | RNA-binding | Signal		
Rhipicephalus sanguineus	34632	A0A9D4SWK8	DNA replication licensing factor MCM6		362	Unreviewed	Nucleus	DNA replication initiation | double-strand break repair via break-induced replication | mitotic DNA replication	ATP binding | hydrolase activity | single-stranded 3'-5' DNA helicase activity | single-stranded DNA binding	MCM complex | nucleus	ATP-binding | Cell cycle | DNA replication | DNA-binding | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Reference proteome		Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity
Rhipicephalus sanguineus	34632	A0A9D4SZW9	(3R)-3-hydroxyacyl-CoA dehydrogenase		250	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4SW83	Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1		176	Unreviewed	Membrane	phospholipid biosynthetic process	phosphatidylglycerophosphatase activity | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | phosphoprotein phosphatase activity	cytoplasm | membrane	Hydrolase | Lipid biosynthesis | Lipid metabolism | Membrane | Phospholipid biosynthesis | Phospholipid metabolism | Protein phosphatase | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4SVN4	(3R)-3-hydroxyacyl-CoA dehydrogenase		253	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4SV53	Presenilin		553	Unreviewed	Endoplasmic reticulum membrane | Golgi apparatus membrane	amyloid-beta formation | calcium ion homeostasis | membrane protein ectodomain proteolysis | Notch signaling pathway | protein processing	aspartic endopeptidase activity, intramembrane cleaving	endoplasmic reticulum membrane | gamma-secretase complex | Golgi membrane	Endoplasmic reticulum | Golgi apparatus | Hydrolase | Membrane | Notch signaling pathway | Protease | Reference proteome | Transmembrane | Transmembrane helix		Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors
Rhipicephalus sanguineus	34632	A0A9D4SV35	Phosphotransferase		474	Unreviewed		glucose metabolic process | glycolytic process | intracellular glucose homeostasis	ATP binding | D-glucose binding | fructokinase activity | glucokinase activity	cytosol | mitochondrion	ATP-binding | Glycolysis | Kinase | Nucleotide-binding | Reference proteome | Transferase		Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate
Rhipicephalus sanguineus	34632	A0A9D4SUR1	E3 ubiquitin-protein ligase CBL		718	Unreviewed		cell surface receptor signaling pathway | regulation of signaling	calcium ion binding | phosphotyrosine residue binding | receptor tyrosine kinase binding | SH3 domain binding | ubiquitin protein ligase activity | zinc ion binding	membrane raft | plasma membrane	Calcium | Metal-binding | Reference proteome | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome
Rhipicephalus sanguineus	34632	A0A9D4SUP0	alpha-1,2-Mannosidase		638	Unreviewed	Endomembrane system	carbohydrate metabolic process	calcium ion binding | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum | Golgi membrane	Calcium | Disulfide bond | Glycosidase | Hydrolase | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transmembrane | Transmembrane helix		Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)
Rhipicephalus sanguineus	34632	A0A9D4SUG2	Angiotensin-converting enzyme		638	Unreviewed		proteolysis	carboxypeptidase activity | metal ion binding | metallopeptidase activity | peptidyl-dipeptidase activity	membrane	Carboxypeptidase | Disulfide bond | Glycoprotein | Hydrolase | Metal-binding | Metalloprotease | Protease | Reference proteome | Signal | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4SUD9	Protein hedgehog		307	Unreviewed	Cell membrane	anatomical structure morphogenesis | cell fate specification | cell-cell signaling | protein autoprocessing | regulation of gene expression | segment polarity determination | smoothened signaling pathway	calcium ion binding | morphogen activity | patched binding | peptidase activity | transferase activity	extracellular space | plasma membrane	Autocatalytic cleavage | Calcium | Cell membrane | Developmental protein | Hydrolase | Lipoprotein | Membrane | Metal-binding | Morphogen | Palmitate | Protease | Reference proteome | Segmentation polarity protein | Signal | Transferase		The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product. Once cleaved, the C-product has no signaling activity and diffuses from the cell
Rhipicephalus sanguineus	34632	A0A9D4SUA6	Mothers against decapentaplegic homolog		359	Unreviewed	Cytoplasm | Nucleus	activin receptor signaling pathway | anatomical structure morphogenesis | cell differentiation | positive regulation of transcription by RNA polymerase II | post-embryonic development | regulation of developmental process | regulation of multicellular organismal process | SMAD protein signal transduction	DNA-binding transcription factor activity, RNA polymerase II-specific | I-SMAD binding | metal ion binding | RNA polymerase II cis-regulatory region sequence-specific DNA binding	cytoplasm | heteromeric SMAD protein complex	Cytoplasm | Metal-binding | Nucleus | Reference proteome | Transcription | Transcription regulation | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4SU09	Hepatocyte growth factor receptor		1285	Unreviewed	Membrane	regulation of cell migration	ATP binding | protein kinase activity | semaphorin receptor activity	plasma membrane | semaphorin receptor complex	ATP-binding | Membrane | Nucleotide-binding | Reference proteome | Repeat | Signal | Transmembrane | Transmembrane helix | Ubl conjugation		
Rhipicephalus sanguineus	34632	A0A9D4STY4	Translin		215	Unreviewed	Cytoplasm | Nucleus	RNA metabolic process	endonuclease activity | hydrolase activity | metal ion binding | RNA binding | sequence-specific DNA binding | single-stranded DNA binding	cytoplasm | nucleus	Cytoplasm | DNA-binding | Endonuclease | Hydrolase | Magnesium | Metal-binding | Nuclease | Nucleus | Reference proteome | RNA-binding		DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots
Rhipicephalus sanguineus	34632	A0A9D4STY2	Protein kinase domain-containing protein		306	Unreviewed	Nucleus	cell division | G2/M transition of mitotic cell cycle | mitotic G2 DNA damage checkpoint signaling | positive regulation of cell cycle process | positive regulation of meiotic cell cycle	ATP binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	nucleus	ATP-binding | Cell cycle | Cell division | Kinase | Mitosis | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4STE8	Aminopeptidase		615	Unreviewed	Cell membrane | Membrane	peptide catabolic process | proteolysis	metalloaminopeptidase activity | peptide binding | zinc ion binding	cytoplasm | extracellular space | plasma membrane	Aminopeptidase | Glycoprotein | Hydrolase | Membrane | Metal-binding | Metalloprotease | Protease | Reference proteome | Signal-anchor | Transmembrane | Transmembrane helix | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4ST82	DNA-(apurinic or apyrimidinic site) endonuclease 2		302	Unreviewed		base-excision repair	DNA binding | DNA-(apurinic or apyrimidinic site) endonuclease activity | double-stranded DNA 3'-5' DNA exonuclease activity | phosphoric diester hydrolase activity | zinc ion binding	nucleus	Hydrolase | Magnesium | Manganese | Metal-binding | Nucleus | Reference proteome | Zinc | Zinc-finger		
Rhipicephalus sanguineus	34632	A0A9D4SVP4	Kinesin motor domain-containing protein		1312	Unreviewed	Cytoplasm, cytoskeleton, spindle | Membrane	microtubule-based movement | mitotic spindle assembly | spindle elongation	ATP binding | microtubule binding | plus-end-directed microtubule motor activity | serine-type endopeptidase activity	membrane | mitotic spindle | nucleus | spindle microtubule	ATP-binding | Coiled coil | Cytoplasm | Cytoskeleton | Membrane | Motor protein | Nucleotide-binding | Phosphoprotein | Reference proteome | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4SS10	NUDE domain-containing protein		196	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Cytoplasm, cytoskeleton, spindle	cell migration | centrosome localization | chromosome segregation | establishment of mitotic spindle orientation | microtubule nucleation | mitotic centrosome separation | vesicle transport along microtubule	microtubule binding	centrosome | kinesin complex | kinetochore | microtubule | spindle	Coiled coil | Cytoplasm | Cytoskeleton | Microtubule | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4T044	Ubiquitin-conjugating enzyme E2 Z		348	Unreviewed	Cytoplasm | Nucleus	apoptotic process | negative regulation of apoptotic process	ATP binding | cysteine-type endopeptidase inhibitor activity | ubiquitin conjugating enzyme activity	cytoplasm | nucleus	Apoptosis | ATP-binding | Cytoplasm | Nucleotide-binding | Nucleus | Reference proteome | Transferase | Ubl conjugation pathway		
Rhipicephalus sanguineus	34632	A0A9D4T0C8	Isocitrate dehydrogenase [NADP]		416	Unreviewed		glyoxylate cycle | isocitrate metabolic process | NADP+ metabolic process | tricarboxylic acid cycle	isocitrate dehydrogenase (NADP+) activity | magnesium ion binding | NAD binding	cytosol | mitochondrion | peroxisome	Glyoxylate bypass | Magnesium | Manganese | Metal-binding | NADP | Oxidoreductase | Reference proteome | Tricarboxylic acid cycle		
Rhipicephalus sanguineus	34632	A0A9D4T4V6	ribonuclease III		2096	Unreviewed	Cytoplasm	anatomical structure morphogenesis | apoptotic DNA fragmentation | developmental process involved in reproduction | post-transcriptional gene silencing | pre-miRNA processing | response to stress | siRNA processing | system development	ATP binding | deoxyribonuclease I activity | helicase activity | metal ion binding | ribonuclease III activity | RNA binding	cytosol | nucleus | RISC-loading complex	ATP-binding | Cytoplasm | Endonuclease | Helicase | Hydrolase | Magnesium | Manganese | Metal-binding | Nuclease | Nucleotide-binding | Phosphoprotein | Reference proteome | Repeat | RNA-binding | RNA-mediated gene silencing		
Rhipicephalus sanguineus	34632	A0A9D4T4P0	m7GpppX diphosphatase		337	Unreviewed	Cytoplasm | Nucleus	deadenylation-dependent decapping of nuclear-transcribed mRNA | mRNA processing | RNA splicing	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity | RNA 7-methylguanosine cap binding	nucleus | P-body	Acetylation | Cytoplasm | Hydrolase | mRNA processing | mRNA splicing | Nucleus | Phosphoprotein | Reference proteome		Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway
Rhipicephalus sanguineus	34632	A0A9D4T4K4	Sialin		487	Unreviewed	Basolateral cell membrane | Cytoplasmic vesicle, secretory vesicle membrane | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane | Lysosome membrane	carboxylic acid transport | monoatomic anion transport	symporter activity	basolateral plasma membrane | lysosomal membrane | synaptic vesicle membrane	Cell membrane | Cytoplasmic vesicle | Glycoprotein | Lysosome | Membrane | Reference proteome | Symport | Synapse | Transmembrane | Transmembrane helix | Transport		Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties
Rhipicephalus sanguineus	34632	A0A9D4T4H7	Asparaginase		363	Unreviewed		L-asparagine catabolic process via L-aspartate | proteolysis	asparaginase activity | beta-aspartyl-peptidase activity	cytoplasm	Autocatalytic cleavage | Hydrolase | Protease | Reference proteome		Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine
Rhipicephalus sanguineus	34632	A0A9D4T3Z1	E1 ubiquitin-activating enzyme		1064	Unreviewed		protein sumoylation	ATP binding | SUMO activating enzyme activity | ubiquitin activating enzyme activity	cytoplasm | SUMO activating enzyme complex	ATP-binding | Ligase | Nucleotide-binding | Reference proteome | Ubl conjugation pathway		
Rhipicephalus sanguineus	34632	A0A9D4T3X6	serine C-palmitoyltransferase		488	Unreviewed	Endoplasmic reticulum membrane	ceramide biosynthetic process | sphingosine biosynthetic process	pyridoxal phosphate binding | serine C-palmitoyltransferase activity	endoplasmic reticulum membrane | serine palmitoyltransferase complex	Acyltransferase | Endoplasmic reticulum | Lipid metabolism | Membrane | Pyridoxal phosphate | Reference proteome | Sphingolipid metabolism | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4T3J9	Beta-1,4-glucuronyltransferase 1		471	Unreviewed	Golgi apparatus membrane	protein O-linked glycosylation via mannose	glucuronosyltransferase activity | metal ion binding	Golgi membrane	Glycoprotein | Glycosyltransferase | Golgi apparatus | Manganese | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4T3J1	Peroxisomal trans-2-enoyl-CoA reductase		133	Unreviewed	Peroxisome	fatty acid biosynthetic process | phytol metabolic process	trans-2-enoyl-CoA reductase (NADPH) activity	peroxisome	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | NADP | Oxidoreductase | Peroxisome | Phosphoprotein | Reference proteome		Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity
Rhipicephalus sanguineus	34632	A0A9D4T2X8	Ubiquitin-conjugating enzyme E2 Z		346	Unreviewed	Cytoplasm | Nucleus	apoptotic process | negative regulation of apoptotic process	ATP binding | cysteine-type endopeptidase inhibitor activity | ubiquitin conjugating enzyme activity	cytoplasm | nucleus	Apoptosis | ATP-binding | Cytoplasm | Nucleotide-binding | Nucleus | Reference proteome | Transferase | Ubl conjugation pathway		
Rhipicephalus sanguineus	34632	A0A9D4T2R8	Adenylate kinase isoenzyme 6 homolog		154	Unreviewed	Cytoplasm | Nucleus	ribosomal small subunit biogenesis | rRNA processing	AMP kinase activity | ATP binding | ATP hydrolysis activity	cytoplasm | nucleus	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Nucleus | Reference proteome | Ribosome biogenesis | rRNA processing | Transferase		Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis
Rhipicephalus sanguineus	34632	A0A9D4T2H8	Histone-lysine N-methyltransferase Suv4-20		890	Unreviewed	Cell junction | Cell membrane | Chromosome | Nucleus	exocytosis | methylation | protein transport	histone H4K20me methyltransferase activity	anchoring junction | chromosome | nucleus | plasma membrane	Cell junction | Cell membrane | Chromatin regulator | Chromosome | Exocytosis | Membrane | Methyltransferase | Nucleus | Protein transport | Reference proteome | Repressor | S-adenosyl-L-methionine | Transcription | Transcription regulation | Transferase | Transport		
Rhipicephalus sanguineus	34632	A0A9D4T2F7	Mitochondrial 2-oxodicarboxylate carrier		323	Unreviewed	Mitochondrion inner membrane	transmembrane transport		mitochondrial inner membrane	Membrane | Mitochondrion | Mitochondrion inner membrane | Reference proteome | Repeat | Transmembrane | Transmembrane helix | Transport		Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle
Rhipicephalus sanguineus	34632	A0A9D4T2B5	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A		759	Unreviewed	Endoplasmic reticulum membrane	post-translational protein modification | protein N-linked glycosylation via asparagine	dolichyl-diphosphooligosaccharide-protein glycotransferase activity | metal ion binding	endoplasmic reticulum membrane	Endoplasmic reticulum | Glycoprotein | Glycosyltransferase | Magnesium | Manganese | Membrane | Metal-binding | Reference proteome | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4T060	ATP-dependent DNA helicase		531	Unreviewed	Nucleus	double-strand break repair via homologous recombination	3'-5' DNA helicase activity | ATP binding | DNA binding | four-way junction helicase activity | hydrolase activity | metal ion binding	chromosome | cytoplasm | nucleus	ATP-binding | DNA-binding | Helicase | Hydrolase | Isomerase | Metal-binding | Nucleotide-binding | Nucleus | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4T277	Beta-1,4-N-acetylgalactosaminyltransferase		388	Unreviewed	Membrane	carbohydrate metabolic process | glycosphingolipid biosynthetic process	galactosyltransferase activity | metal ion binding | N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity	Golgi apparatus | membrane	Glycoprotein | Glycosyltransferase | Manganese | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		Catalyzes the transfer of galactose onto proteins or lipids
Rhipicephalus sanguineus	34632	A0A9D4T1S1	Beta-1,4-N-acetylgalactosaminyltransferase		417	Unreviewed	Membrane	carbohydrate metabolic process | glycosphingolipid biosynthetic process	galactosyltransferase activity | metal ion binding | N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity	Golgi apparatus | membrane	Glycoprotein | Glycosyltransferase | Manganese | Membrane | Metal-binding | Reference proteome | Signal | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		Catalyzes the transfer of galactose onto proteins or lipids
Rhipicephalus sanguineus	34632	A0A9D4T1P8	Guanylate cyclase soluble subunit beta-1		698	Unreviewed	Cytoplasm	cGMP-mediated signaling | response to oxygen levels	GTP binding | guanylate cyclase activity | heme binding | metal ion binding	guanylate cyclase complex, soluble	cGMP biosynthesis | Coiled coil | Cytoplasm | GTP-binding | Heme | Iron | Lyase | Metal-binding | Nucleotide-binding | Reference proteome		Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP
Rhipicephalus sanguineus	34632	A0A9D4T1C0	Glucosylceramidase		1011	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process	glucosylceramidase activity | hexosyltransferase activity | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Reference proteome | Signal | Sphingolipid metabolism		
Rhipicephalus sanguineus	34632	A0A9D4T1B5	4-hydroxy-2-oxoglutarate aldolase, mitochondrial		323	Unreviewed		small molecule metabolic process	(R,S)-4-hydroxy-2-oxoglutarate aldolase activity | 4-hydroxy-tetrahydrodipicolinate synthase activity		Lyase | Reference proteome | Schiff base		Catalyzes the final step in the metabolic pathway of hydroxyproline
Rhipicephalus sanguineus	34632	A0A9D4T177	Phospholipid-transporting ATPase		1212	Unreviewed	Endoplasmic reticulum membrane | Membrane	phospholipid translocation	ATP binding | ATP hydrolysis activity | flippase activity | magnesium ion binding	endoplasmic reticulum membrane | plasma membrane	ATP-binding | Endoplasmic reticulum | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Reference proteome | Translocase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4T164	Mitochondrial 2-oxodicarboxylate carrier		304	Unreviewed	Mitochondrion inner membrane	transmembrane transport		mitochondrial inner membrane	Membrane | Mitochondrion | Mitochondrion inner membrane | Reference proteome | Repeat | Transmembrane | Transmembrane helix | Transport		Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle
Rhipicephalus sanguineus	34632	A0A9D4T149	Amine oxidase		239	Unreviewed	Mitochondrion outer membrane		flavin adenine dinucleotide binding | monoamine oxidase activity | primary methylamine oxidase activity	mitochondrial outer membrane	FAD | Flavoprotein | Membrane | Oxidoreductase | Reference proteome | Transmembrane | Transmembrane helix		Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine
Rhipicephalus sanguineus	34632	A0A9D4T104	Cyclin-dependent kinase 12		732	Unreviewed	Nucleus	positive regulation of transcription elongation by RNA polymerase II	ATP binding | cyclin binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	cyclin/CDK positive transcription elongation factor complex	ATP-binding | Kinase | Nucleotide-binding | Nucleus | Reference proteome | Serine/threonine-protein kinase | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4T0S8	Sterol regulatory element-binding protein cleavage-activating protein		1139	Unreviewed	Cytoplasmic vesicle, COPII-coated vesicle membrane | Endoplasmic reticulum membrane | Golgi apparatus membrane	cholesterol metabolic process | regulation of cholesterol biosynthetic process | SREBP signaling pathway	sterol binding	endoplasmic reticulum membrane | ER to Golgi transport vesicle membrane | Golgi membrane | SREBP-SCAP complex	Cholesterol metabolism | Cytoplasmic vesicle | Endoplasmic reticulum | Glycoprotein | Golgi apparatus | Lipid metabolism | Lipid-binding | Membrane | Reference proteome | Repeat | Steroid metabolism | Sterol metabolism | Transmembrane | Transmembrane helix | WD repeat		Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain
Rhipicephalus sanguineus	34632	A0A9D4T0R2	Receptor protein-tyrosine kinase		1455	Unreviewed	Membrane	ERBB signaling pathway | negative regulation of apoptotic process | neurogenesis | positive regulation of cell population proliferation | regulation of signal transduction	ATP binding | transmembrane receptor protein tyrosine kinase activity	basal plasma membrane | receptor complex	ATP-binding | Glycoprotein | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Receptor | Reference proteome | Signal | Transferase | Transmembrane | Transmembrane helix | Tyrosine-protein kinase		
Rhipicephalus sanguineus	34632	A0A9D4T0Q6	Large ribosomal subunit protein uL10		706	Unreviewed		cytoplasmic translation | DNA repair | ribosomal large subunit assembly	large ribosomal subunit rRNA binding | phosphoric diester hydrolase activity | structural constituent of ribosome	cytosolic large ribosomal subunit | nucleus	Phosphoprotein | Reference proteome | Ribonucleoprotein | Ribosomal protein		Ribosomal protein P0 is the functional equivalent of E.coli protein L10
Rhipicephalus sanguineus	34632	A0A9D4T0P0	ATP citrate synthase		889	Unreviewed	Cytoplasm	acetyl-CoA biosynthetic process | fatty acid biosynthetic process	ATP binding | ATP citrate synthase activity | metal ion binding	cytosol	ATP-binding | Cytoplasm | Lipid biosynthesis | Lipid metabolism | Magnesium | Metal-binding | Nucleotide-binding | Phosphoprotein | Reference proteome | Transferase		Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism
Rhipicephalus sanguineus	34632	A0A9D4T0J4	Polypeptide N-acetylgalactosaminyltransferase		616	Unreviewed	Golgi apparatus membrane	protein O-linked glycosylation	carbohydrate binding | metal ion binding | polypeptide N-acetylgalactosaminyltransferase activity	Golgi membrane	Disulfide bond | Glycoprotein | Glycosyltransferase | Golgi apparatus | Lectin | Manganese | Membrane | Metal-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4T1Y2	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1		376	Unreviewed	Membrane		glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity | manganese ion binding | nucleotide binding	membrane	Disulfide bond | Glycoprotein | Glycosyltransferase | Manganese | Membrane | Metal-binding | Nucleotide-binding | Reference proteome | Signal-anchor | Transferase | Transmembrane | Transmembrane helix		Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins
Rhipicephalus sanguineus	34632	A0A9D4PUC4	Homeobox domain-containing protein		799	Unreviewed	Lysosome | Nucleus envelope	anatomical structure formation involved in morphogenesis | cell division | cellular response to amino acid starvation | eye development | neuron fate commitment | positive regulation of TORC1 signaling | protein transport | regulation of DNA-templated transcription	cis-regulatory region sequence-specific DNA binding | structural molecule activity	lysosome | nuclear pore outer ring | Seh1-associated complex	Cell cycle | Cell division | DNA-binding | Homeobox | Lysosome | Mitosis | Nucleus | Protein transport | Reference proteome | Repeat | Transport | WD repeat		
Rhipicephalus sanguineus	34632	A0A9D4PB29	Dual specificity protein phosphatase		223	Unreviewed		negative regulation of MAPK cascade	MAP kinase phosphatase activity | protein serine/threonine phosphatase activity | protein tyrosine phosphatase activity | protein tyrosine/serine/threonine phosphatase activity	cytoplasm	Hydrolase | Protein phosphatase | Reference proteome		Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate
Rhipicephalus sanguineus	34632	A0A9D4PTI1	Exosome complex component 10 homolog		767	Unreviewed	Nucleus	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | histone mRNA catabolic process | nuclear polyadenylation-dependent antisense transcript catabolic process | nuclear polyadenylation-dependent CUT catabolic process | nuclear polyadenylation-dependent rRNA catabolic process | nuclear polyadenylation-dependent snoRNA catabolic process | nuclear polyadenylation-dependent snRNA catabolic process | poly(A)-dependent snoRNA 3'-end processing | TRAMP-dependent tRNA surveillance pathway	3'-5'-RNA exonuclease activity | nucleotide binding | single-stranded RNA binding	nuclear exosome (RNase complex) | nucleolus	Exonuclease | Exosome | Hydrolase | Nuclease | Nucleus | Reference proteome | rRNA processing		
Rhipicephalus sanguineus	34632	A0A1S5RSG4	Cytochrome c oxidase subunit 1	COI	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1S5RSG2	Cytochrome c oxidase subunit 1	COI	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1S5RSF2	Cytochrome c oxidase subunit 1	COI	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1S5RSE3	Cytochrome c oxidase subunit 1	COI	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1S5RSE1	Cytochrome c oxidase subunit 1	COI	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1S5RSC5	Cytochrome c oxidase subunit 1	COI	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1Q1M936	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1P8SCW4	Cytochrome c oxidase subunit 1	COI	256	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1P8SCW1	Cytochrome c oxidase subunit 1	COI	241	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1P8SCV9	Cytochrome c oxidase subunit 1	COI	256	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1P8SCV3	Cytochrome c oxidase subunit 1	COI	253	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1P8SCV2	Cytochrome c oxidase subunit 1	COI	238	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1P8SCV0	Cytochrome c oxidase subunit 1	COI	254	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1P8SCU5	Cytochrome c oxidase subunit 1	COI	232	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A9D4PU01	Glyceraldehyde-3-phosphate dehydrogenase		371	Unreviewed		glucose metabolic process | glycolytic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | NAD binding | NADP binding	cytosol	Glycolysis | NAD | Nucleotide-binding | Oxidoreductase | Reference proteome		
Rhipicephalus sanguineus	34632	A0A1P8SCU3	Cytochrome c oxidase subunit 1	COI	240	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1P8SCU0	Cytochrome c oxidase subunit 1	COI	254	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1P8SCT8	Cytochrome c oxidase subunit 1	COI	248	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1P8DIB4	Cytochrome c oxidase subunit 1	COI	174	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1B2FQE7	Cytochrome c oxidase subunit 1		200	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1B1JE90	Cytochrome c oxidase subunit 1	COI	198	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1B1JE89	Cytochrome c oxidase subunit 1	COI	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1B1JE88	Cytochrome c oxidase subunit 1	COI	208	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1B1JE87	Cytochrome c oxidase subunit 1	COI	217	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1B1JE86	Cytochrome c oxidase subunit 1	COI	193	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1B1JE85	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1B1JE84	Cytochrome c oxidase subunit 1	COI	184	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1S5RSG5	Cytochrome c oxidase subunit 1	COI	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1B1JE83	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1Z1VNJ1	Cytochrome c oxidase subunit 1	COI	241	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A286R109	Cytochrome c oxidase subunit 1	COI	261	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1G1	Cytochrome c oxidase subunit 1	COI	213	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1D7	Cytochrome c oxidase subunit 1	COI	228	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1D6	Cytochrome c oxidase subunit 1	COI	224	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1D4	Cytochrome c oxidase subunit 1	COI	232	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1D3	Cytochrome c oxidase subunit 1	COI	270	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1D2	Cytochrome c oxidase subunit 1	COI	234	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1D1	Cytochrome c oxidase subunit 1	COI	231	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1D0	Cytochrome c oxidase subunit 1	COI	229	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1C9	Cytochrome c oxidase subunit 1	COI	269	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1C8	Cytochrome c oxidase subunit 1	COI	275	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1C7	Cytochrome c oxidase subunit 1	COI	226	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1C4	Cytochrome c oxidase subunit 1	COI	229	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1C3	Cytochrome c oxidase subunit 1	COI	227	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1C2	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H1C1	Cytochrome c oxidase subunit 1	COI	191	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2R4H180	Cytochrome c oxidase subunit 1	COI	218	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2I4KED2	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2I4KEC4	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2I4KEC0	Cytochrome c oxidase subunit 1	COI	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2I4KEB2	Cytochrome c oxidase subunit 1	COI	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2I4KE78	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2I4KE73	Cytochrome c oxidase subunit 1	COI	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2I4KE72	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2I4KE71	Cytochrome c oxidase subunit 1	COI	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2I4KE70	Cytochrome c oxidase subunit 1	COI	203	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2I4KE66	Cytochrome c oxidase subunit 1	COI	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A2H4V615	Cytochrome c oxidase subunit 1	COI	70	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1Z1VP39	Cytochrome c oxidase subunit 1	COI	241	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1B0UW11	Cytochrome c oxidase subunit 1	COX1	230	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1B0UW09	Cytochrome c oxidase subunit 1	COX1	230	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1B0UVQ5	Cytochrome c oxidase subunit 1	COX1	230	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A9D4P980	Lysine-specific histone demethylase		798	Unreviewed	Chromosome | Nucleus	DNA repair-dependent chromatin remodeling | negative regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | positive regulation of multicellular organismal process | positive regulation of neural precursor cell proliferation | positive regulation of transcription by RNA polymerase II | regulation of neurogenesis	chromatin binding | enzyme binding | FAD-dependent H3K4me/H3K4me3 demethylase activity | flavin adenine dinucleotide binding | histone H3K9 demethylase activity | MRF binding | RNA binding | RNA polymerase II-specific DNA-binding transcription factor binding | transcription coactivator activity | transcription corepressor activity	chromatin | nucleus	Acetylation | Chromatin regulator | Chromosome | Coiled coil | Developmental protein | FAD | Flavoprotein | Isopeptide bond | Nucleus | Oxidoreductase | Phosphoprotein | Reference proteome | Repressor | Transcription | Transcription regulation | Ubl conjugation		Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3
Rhipicephalus sanguineus	34632	A0A9D4T4Z2	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D		508	Unreviewed	Early endosome membrane | Endosome membrane | Golgi apparatus membrane | Nucleus envelope | Nucleus, nucleoplasm	N-acylethanolamine metabolic process | N-acylphosphatidylethanolamine metabolic process | phospholipid catabolic process | RNA 3'-end processing	metal ion binding | N-acylphosphatidylethanolamine-specific phospholipase D activity	early endosome membrane | Golgi membrane | nuclear envelope | nucleoplasm	Acetylation | Endosome | Golgi apparatus | Hydrolase | Lipid degradation | Lipid metabolism | Membrane | Metal-binding | Nucleus | Phospholipid degradation | Phospholipid metabolism | Reference proteome | Zinc		D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs
Rhipicephalus sanguineus	34632	A0A9D4SSN9	Fatty acid synthase		2386	Unreviewed		fatty acid biosynthetic process	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity | 3-oxoacyl-[acyl-carrier-protein] synthase activity | [acyl-carrier-protein] S-acetyltransferase activity | enoyl-[acyl-carrier-protein] reductase (NADPH) activity | fatty acid synthase activity | fatty acyl-[ACP] hydrolase activity | phosphopantetheine binding		Acetylation | Fatty acid biosynthesis | Fatty acid metabolism | Hydrolase | Lipid biosynthesis | Lipid metabolism | Multifunctional enzyme | NAD | NADP | Oxidoreductase | Phosphopantetheine | Phosphoprotein | Pyridoxal phosphate | Reference proteome | S-nitrosylation | Transferase		Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain
Rhipicephalus sanguineus	34632	A0A9D4SSG4	Uncharacterized protein		346	Unreviewed		amide biosynthetic process | amide catabolic process | amino acid metabolic process | proteolysis	aminoacylase activity | metal ion binding | peptidase activity		Hydrolase | Membrane | Metal-binding | Protease | Reference proteome | Transmembrane | Transmembrane helix | Zinc		Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles
Rhipicephalus sanguineus	34632	A0A9D4SQK2	Fatty acid synthase		2669	Unreviewed		fatty acid biosynthetic process	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity | 3-oxoacyl-[acyl-carrier-protein] synthase activity | [acyl-carrier-protein] S-acetyltransferase activity | [acyl-carrier-protein] S-malonyltransferase activity | enoyl-[acyl-carrier-protein] reductase (NADPH) activity | fatty acid synthase activity | fatty acyl-[ACP] hydrolase activity | phosphopantetheine binding		Acetylation | Fatty acid biosynthesis | Fatty acid metabolism | Hydrolase | Lipid biosynthesis | Lipid metabolism | Lyase | Multifunctional enzyme | NAD | NADP | Oxidoreductase | Phosphopantetheine | Phosphoprotein | Pyridoxal phosphate | Reference proteome | S-nitrosylation | Transferase		Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain
Rhipicephalus sanguineus	34632	A0A9D4PLI1	Peptidase M20 dimerisation domain-containing protein		216	Unreviewed		amide biosynthetic process | amide catabolic process | amino acid metabolic process | proteolysis	aminoacylase activity | metal ion binding | peptidase activity		Hydrolase | Metal-binding | Protease | Reference proteome | Zinc		Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles
Rhipicephalus sanguineus	34632	P84554	Kunitz-type serine protease inhibitor RsTIQ2		31	Reviewed			serine-type endopeptidase inhibitor activity		Direct protein sequencing | Disulfide bond | Protease inhibitor | Serine protease inhibitor		Serine protease inhibitor. Inhibits trypsin, elastase, plasmin and kallikrein
Rhipicephalus sanguineus	34632	P0DQV2	Complement inhibitor CirpT3		111	Reviewed	Secreted			extracellular region	Disulfide bond | Secreted | Signal		Complement inhibitor (PubMed:31871188). Prevents complement-mediated activation of C5 by sterically preventing direct binding of C5 to its convertase (binding with domains MG4 and MG5) (By similarity) (PubMed:31871188). Binds C5 at a different binding site than the other tick complement inhibitors OmCI and RaCI3, and the drug eculizumab (By similarity). Inhibits the complement in human, rat and guinea pig, and also shows a reduced inhibition in rabbit and pig (By similarity)
Rhipicephalus sanguineus	34632	O99825	NADH-ubiquinone oxidoreductase chain 4	ND4	433	Reviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Rhipicephalus sanguineus	34632	O99817	NADH-ubiquinone oxidoreductase chain 2	ND2	313	Reviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Rhipicephalus sanguineus	34632	O99824	NADH-ubiquinone oxidoreductase chain 1	ND1	313	Reviewed	Mitochondrion inner membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Rhipicephalus sanguineus	34632	P84555	Kunitz-type serine protease inhibitor RsTIQ7		29	Reviewed			serine-type endopeptidase inhibitor activity		Direct protein sequencing | Disulfide bond | Protease inhibitor | Serine protease inhibitor		Serine protease inhibitor. Inhibits trypsin, elastase, plasmin and kallikrein
Rhipicephalus sanguineus	34632	O99823	NADH-ubiquinone oxidoreductase chain 3	ND3	114	Reviewed	Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Rhipicephalus sanguineus	34632	M1NRH7	Japanin-like-RS		176	Reviewed	Secreted			extracellular region	Disulfide bond | Glycoprotein | Secreted | Signal		Salivary tick protein that modulates host immune response. This protein blocks dendritic cell (DC) differentiation from monocytes (PubMed:23825947). In addition, it inhibits up-regulation of costimulatory molecules and pro-inflammatory cytokines in response to stimuli and promotes up-regulation of co-inhibitory molecules and the anti-inflammatory cytokine interleukin-10. It has a pocket to accomodate cholesterol, which may have immune-modulatory roles, either directly or through interactions with the host gut microbiota (By similarity)
Rhipicephalus sanguineus	34632	P84556	Kunitz-type serine protease inhibitor RsTIS5		25	Reviewed			serine-type endopeptidase inhibitor activity		Direct protein sequencing | Disulfide bond | Protease inhibitor | Serine protease inhibitor		Serine protease inhibitor. Inhibits trypsin, elastase and plasmin. Does not inhibit kallikrein
Rhipicephalus sanguineus	34632	Q9ZYM7	NADH-ubiquinone oxidoreductase chain 5	ND5	552	Reviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Rhipicephalus sanguineus	34632	O99827	NADH-ubiquinone oxidoreductase chain 6	ND6	149	Reviewed	Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Rhipicephalus sanguineus	34632	O99826	NADH-ubiquinone oxidoreductase chain 4L	ND4L	91	Reviewed	Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Rhipicephalus sanguineus	34632	O99822	Cytochrome c oxidase subunit 3	COIII	257	Reviewed	Mitochondrion inner membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrial inner membrane	Membrane | Mitochondrion | Mitochondrion inner membrane | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	O99819	Cytochrome c oxidase subunit 2	COII	225	Reviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	O99828	Cytochrome b	MT-CYB	358	Reviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus sanguineus	34632	O99818	Cytochrome c oxidase subunit 1	COI	512	Reviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Calcium | Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	O99820	ATP synthase protein 8	MT-ATP8	52	Reviewed	Mitochondrion membrane	ATP biosynthetic process | proton transmembrane transport		mitochondrial membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity)
Rhipicephalus sanguineus	34632	O99821	ATP synthase subunit a	ATP6	221	Reviewed	Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Mitochondrion inner membrane | Transmembrane | Transmembrane helix | Transport		Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane
Rhipicephalus sanguineus	34632	P0C8E8	Evasin-3		86	Reviewed	Secreted	negative regulation of chemokine activity | negative regulation of protein homodimerization activity	C-X-C chemokine binding	extracellular region	3D-structure | Direct protein sequencing | Disulfide bond | Glycoprotein | Secreted | Signal	6I31 | 6QJB	Salivary chemokine-binding protein which shows chemokine neutralizing activity and binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL6 and CXCL8 (PubMed:18678732, PubMed:31167786, PubMed:31235521). Binds to CXCL8 with 1:1 stoichiometry (PubMed:31235521). Disrupts CXCL8 homodimer formation, disrupts the glycosaminoglycan-binding site of CXCL8 and inhibits the interaction of CXCL8 with CXCR2 (PubMed:31235521)
Rhipicephalus sanguineus	34632	P0C8E9	Evasin-4		127	Reviewed	Secreted	negative regulation of chemokine activity	C-C chemokine binding	extracellular region	3D-structure | Disulfide bond | Glycoprotein | Secreted | Signal	6ST4 | 6STC | 6STE	Salivary chemokine-binding protein which has chemokine-neutralizing activity and binds to host chemokines CCL1, CCL3, CCL5, CCL7, CCL8, CCL11, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL21, CCL22, CCL23, CCL24, CCL25 and CCL26 with nanomolar affinity (PubMed:18678732, PubMed:23910450, PubMed:25266725). Binds to CCL3 and CCL5 with 1:1 stoichiometry (PubMed:23910450). Although binding to CCL25 is observed, does not inhibit CCL25-induced chemotaxis (PubMed:25266725). Has been shown to reduce cardiac injury and inflammation in mice through its anti-CCL5 activity (PubMed:23925450)
Rhipicephalus sanguineus	34632	P0C8E7	Evasin-1		114	Reviewed	Secreted	negative regulation of chemokine activity	C-C chemokine binding | chemokine binding	extracellular region	3D-structure | Direct protein sequencing | Disulfide bond | Glycoprotein | Secreted | Signal	3FPR | 3FPT | 3FPU	Salivary chemokine-binding protein which shows chemokine neutralizing activity and binds to host chemokines CCL3, CCL4 and CCL18 (PubMed:17640866, PubMed:18678732, PubMed:20041127, PubMed:25266725). Binds to CCL3 with 1:1 stoichiometry (PubMed:20041127)
Rhipicephalus sanguineus	34632	A0A9D4PBT1	Flavin-containing monooxygenase		1547	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Reference proteome | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Rhipicephalus sanguineus	34632	A0A9D4PCE6	Flavin-containing monooxygenase		559	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Reference proteome | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Rhipicephalus sanguineus	34632	A0A9D4PE63	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		255	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase | Reference proteome		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Rhipicephalus sanguineus	34632	A0A9D4PGE4	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		418	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase | Reference proteome		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Rhipicephalus sanguineus	34632	A0A172M5S1	Cytochrome c oxidase subunit 1	CO1	276	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A140EFS0	Cytochrome c oxidase subunit 1	COI	257	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A140EFR9	Cytochrome c oxidase subunit 1	COI	237	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A140EFR8	Cytochrome c oxidase subunit 1	COI	262	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A140EFR7	Cytochrome c oxidase subunit 1	COI	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A0B4MYK8	Cytochrome c oxidase subunit 1		130	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A0B4MYE4	Cytochrome c oxidase subunit 1		128	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A0A7M8Y5	Cytochrome c oxidase subunit 1		512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A0A7CEI1	Cytochrome c oxidase subunit 1		130	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A059Q6G4	Cytochrome c oxidase subunit 1	COI	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A059Q5Z5	Cytochrome c oxidase subunit 1	COI	216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A9D4YQG2	Notch		1937	Unreviewed	Cell membrane | Nucleus | Secreted | Target cell membrane	axon guidance | cell fate specification | embryonic organ development | exocytosis | formation of animal organ boundary | larval development | Notch signaling pathway | ommatidial rotation | positive regulation of neurogenesis | R3/R4 cell differentiation | regulation of cell-cell adhesion | reproductive structure development | sex differentiation	calcium ion binding	cell surface | extracellular region | host cell presynaptic membrane | other organism cell membrane | plasma membrane | receptor complex | RNA polymerase II transcription regulator complex	Activator | ANK repeat | Calcium | Cell membrane | Developmental protein | Differentiation | Disulfide bond | EGF-like domain | Exocytosis | Glycoprotein | Membrane | Metal-binding | Neurotoxin | Notch signaling pathway | Nucleus | Presynaptic neurotoxin | Receptor | Reference proteome | Repeat | Secreted | Signal | Target cell membrane | Target membrane | Toxin | Transcription | Transcription regulation | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4SVY5	Glucosylceramidase		848	Unreviewed		alcohol metabolic process | autophagy | glucosylceramide catabolic process | glycine biosynthetic process from serine | lysosome organization | negative regulation of macromolecule metabolic process | protein catabolic process | regulation of macroautophagy | regulation of membrane potential | regulation of protein metabolic process | regulation of TOR signaling | steroid metabolic process | tetrahydrofolate interconversion	glucosylceramidase activity | glycine hydroxymethyltransferase activity | hexosyltransferase activity | pyridoxal phosphate binding | signaling receptor binding	lysosome | vacuolar membrane	Glycosidase | Hydrolase | Lipid metabolism | Reference proteome | Signal | Sphingolipid metabolism		
Rhipicephalus sanguineus	34632	A0A2R4H1H7	Cytochrome c oxidase subunit 1	COI	216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A9D4SVC9	glycerophosphocholine cholinephosphodiesterase		511	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Rhipicephalus sanguineus	34632	A0A9D4Q771	ATP-dependent 6-phosphofructokinase		788	Unreviewed	Cytoplasm	canonical glycolysis | fructose 1,6-bisphosphate metabolic process | fructose 6-phosphate metabolic process	6-phosphofructokinase activity | AMP binding | ATP binding | fructose-6-phosphate binding | identical protein binding | metal ion binding | monosaccharide binding	6-phosphofructokinase complex	Allosteric enzyme | ATP-binding | Cytoplasm | Glycolysis | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Reference proteome | Transferase		Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
Rhipicephalus sanguineus	34632	A0A9D4Q525	Flavin-containing monooxygenase		566	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Reference proteome | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Rhipicephalus sanguineus	34632	A0A9D4Q4W7	Flavin-containing monooxygenase		400	Unreviewed	Endoplasmic reticulum membrane | Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding | trimethylamine monooxygenase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Reference proteome | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Rhipicephalus sanguineus	34632	A0A9D4Q4S7	Ketimine reductase mu-crystallin		316	Unreviewed			hormone binding | pyrroline-2-carboxylate reductase activity | thiomorpholine-carboxylate dehydrogenase activity	cytoplasm	Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PSN7	glycerophosphocholine cholinephosphodiesterase		417	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Rhipicephalus sanguineus	34632	A0A9D4PSG8	glycerophosphocholine cholinephosphodiesterase		120	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Rhipicephalus sanguineus	34632	A0A9D4PS58	glycerophosphocholine cholinephosphodiesterase		408	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Transmembrane | Transmembrane helix | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Rhipicephalus sanguineus	34632	A0A9D4PRE6	glycerophosphocholine cholinephosphodiesterase		122	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Rhipicephalus sanguineus	34632	A0A9D4PP07	glycerophosphocholine cholinephosphodiesterase		228	Unreviewed	Cell membrane	lipid catabolic process	glycerophosphocholine cholinephosphodiesterase activity | metal ion binding	plasma membrane | side of membrane	Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipid degradation | Lipid metabolism | Lipoprotein | Membrane | Metal-binding | Phosphoprotein | Reference proteome | Signal | Zinc		Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids
Rhipicephalus sanguineus	34632	A0A9D4PMW4	Flavin-containing monooxygenase		357	Unreviewed	Microsome membrane	lipid metabolic process	flavin adenine dinucleotide binding | N,N-dimethylaniline monooxygenase activity | NAD(P)H oxidase H2O2-forming activity | NADP binding		Endoplasmic reticulum | FAD | Flavoprotein | Lipid metabolism | Membrane | Methylation | Microsome | Monooxygenase | NADP | Oxidoreductase | Phosphoprotein | Reference proteome | Transmembrane | Transmembrane helix		Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects
Rhipicephalus sanguineus	34632	A0A9D4PMD1	3-hydroxyacyl-CoA dehydrogenase type-2		262	Unreviewed		androgen metabolic process | estrogen metabolic process | fatty acid metabolic process	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity | androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity | estradiol 17-beta-dehydrogenase [NAD(P)+] activity	mitochondrion	Oxidoreductase | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PMC8	Thromboxane-A synthase		485	Unreviewed	Endoplasmic reticulum membrane	prostaglandin biosynthetic process	heme binding | hydroperoxy icosatetraenoate dehydratase activity | iron ion binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | steroid hydroxylase activity | thromboxane-A synthase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | Fatty acid biosynthesis | Fatty acid metabolism | Heme | Iron | Isomerase | Lipid biosynthesis | Lipid metabolism | Lyase | Membrane | Metal-binding | Monooxygenase | Oxidoreductase | Prostaglandin biosynthesis | Prostaglandin metabolism | Reference proteome | Transmembrane | Transmembrane helix		Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE
Rhipicephalus sanguineus	34632	A0A9D4PGU2	15-hydroxyprostaglandin dehydrogenase [NAD(+)]		256	Unreviewed			15-hydroxyicosatetraenoate dehydrogenase activity | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	cytoplasm	Oxidoreductase | Reference proteome		Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation
Rhipicephalus sanguineus	34632	A0A9D4SPW5	PRKCA-binding protein		446	Unreviewed	Cytoplasm, cytoskeleton | Cytoplasm, perinuclear region | Membrane | Postsynaptic density | Synapse, synaptosome	dendritic spine maintenance | intracellular protein transport | positive regulation of receptor internalization | receptor clustering | regulation of Arp2/3 complex-mediated actin nucleation	actin binding | metal ion binding | phospholipid binding | protein domain specific binding | protein kinase C binding	cytoskeleton | neuron projection | perinuclear region of cytoplasm | plasma membrane | postsynaptic density | postsynaptic early endosome | synaptic vesicle | trans-Golgi network membrane	Actin-binding | Calcium | Cytoplasm | Cytoskeleton | Lipoprotein | Membrane | Metal-binding | Palmitate | Phosphoprotein | Reference proteome | Synapse | Synaptosome | Zinc		Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function
Rhipicephalus sanguineus	34632	A0A2R4H1H8	Cytochrome c oxidase subunit 1	COI	230	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A1P8SCU4	Cytochrome c oxidase subunit 1	COI	245	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A345Z121	Cytochrome c oxidase subunit 1	COI	159	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A9D4PMU0	DNA polymerase		328	Unreviewed	Cytoplasm | Nucleus	base-excision repair | double-strand break repair via nonhomologous end joining	class I DNA-(apurinic or apyrimidinic site) endonuclease activity | DNA binding | DNA-directed DNA polymerase activity | metal ion binding	cytoplasm | nucleus	Cytoplasm | DNA damage | DNA repair | DNA replication | DNA synthesis | DNA-binding | DNA-directed DNA polymerase | Lyase | Magnesium | Metal-binding | Methylation | Nucleotidyltransferase | Nucleus | Reference proteome | Sodium | Transferase | Ubl conjugation		DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity
Rhipicephalus sanguineus	34632	A0A9D4PMR3	Kynureninase		466	Unreviewed	Cytoplasm	'de novo' NAD+ biosynthetic process from L-tryptophan | anthranilate metabolic process | L-kynurenine catabolic process | L-tryptophan catabolic process to kynurenine | quinolinate biosynthetic process	kynureninase activity | pyridoxal phosphate binding	cytoplasm	Cytoplasm | Hydrolase | Pyridine nucleotide biosynthesis | Pyridoxal phosphate | Reference proteome		Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively
Rhipicephalus sanguineus	34632	A0A9D4PMP3	NADPH-dependent diflavin oxidoreductase 1		549	Unreviewed	Cytoplasm	iron-sulfur cluster assembly	flavin adenine dinucleotide binding | FMN binding | NADP binding | NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity | oxidoreductase activity, acting on NAD(P)H	cytosol	Cytoplasm | FAD | Flavoprotein | FMN | NADP | Oxidoreductase | Reference proteome		NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of the anamorsin/DRE2 homolog, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins
Rhipicephalus sanguineus	34632	A0A9D4PMI7	CAAX prenyl protease		395	Unreviewed	Endoplasmic reticulum membrane	CAAX-box protein processing	metal ion binding | metalloendopeptidase activity	endoplasmic reticulum membrane	Endoplasmic reticulum | Hydrolase | Membrane | Metal-binding | Metalloprotease | Protease | Reference proteome | Transmembrane | Transmembrane helix | Zinc		Proteolytically removes the C-terminal three residues of farnesylated proteins
Rhipicephalus sanguineus	34632	A0A9D4PMH0	Aminopeptidase		673	Unreviewed	Cell membrane	peptide catabolic process | proteolysis	metalloaminopeptidase activity | peptide binding | zinc ion binding	cytoplasm | extracellular space | plasma membrane	Hydrolase | Membrane | Metal-binding | Metalloprotease | Protease | Reference proteome | Transmembrane | Transmembrane helix | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4PMA3	Ubiquitin-conjugating enzyme E2 S		187	Unreviewed		anaphase-promoting complex-dependent catabolic process | cell division | exit from mitosis	ATP binding | ubiquitin conjugating enzyme activity		ATP-binding | Cell cycle | Cell division | Nucleotide-binding | Reference proteome | Transferase | Ubl conjugation pathway		
Rhipicephalus sanguineus	34632	A0A9D4PM66	U8 snoRNA-decapping enzyme		221	Unreviewed	Nucleus, nucleolus | Nucleus, nucleoplasm	mRNA catabolic process | nucleotide metabolic process | sno(s)RNA catabolic process	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity | IDP phosphatase activity | phosphodiesterase decapping endonuclease activity | snoRNA binding	nucleolus | nucleoplasm	Hydrolase | Nucleotide metabolism | Nucleus | Reference proteome | RNA-binding		
Rhipicephalus sanguineus	34632	A0A9D4PM48	DNA-(apurinic or apyrimidinic site) endonuclease 2		302	Unreviewed		base-excision repair	DNA binding | DNA-(apurinic or apyrimidinic site) endonuclease activity | double-stranded DNA 3'-5' DNA exonuclease activity | phosphoric diester hydrolase activity | zinc ion binding	nucleus	Hydrolase | Magnesium | Manganese | Metal-binding | Nucleus | Reference proteome | Zinc | Zinc-finger		
Rhipicephalus sanguineus	34632	A0A9D4PM31	Histone acetyltransferase		425	Unreviewed	Nucleus	DNA repair-dependent chromatin remodeling | regulation of DNA-templated transcription	histone H4K16 acetyltransferase activity	MSL complex | NSL complex | NuA4 histone acetyltransferase complex | nucleus | polytene chromosome interband	Acetylation | Nucleus | Reference proteome | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4PLT0	Dystroglycan 1		1023	Unreviewed	Cell membrane, sarcolemma | Cell membrane | Cytoplasm, cytoskeleton | Nucleus, nucleoplasm | Postsynaptic cell membrane | Secreted, extracellular space	axon guidance | morphogenesis of an epithelium | nerve development	calcium ion binding | laminin binding	cytoskeleton | dystroglycan complex | extracellular region | nucleoplasm | postsynaptic membrane | sarcolemma	Cell membrane | Cytoplasm | Cytoskeleton | Disulfide bond | Glycoprotein | Membrane | Nucleus | Phosphoprotein | Postsynaptic cell membrane | Reference proteome | Secreted | Signal | Synapse | Transmembrane | Transmembrane helix		The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization
Rhipicephalus sanguineus	34632	A0A9D4PL86	IST1 homolog		342	Unreviewed	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Cytoplasmic vesicle | Midbody | Nucleus envelope	cell division | protein transport		centrosome | cytoplasmic vesicle | midbody | nuclear envelope	Cell cycle | Cell division | Coiled coil | Cytoplasm | Cytoplasmic vesicle | Cytoskeleton | Nucleus | Phosphoprotein | Reference proteome		ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST
Rhipicephalus sanguineus	34632	A0A9D4PL77	Putative rRNA methyltransferase		805	Unreviewed	Nucleus, nucleolus	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rRNA (guanine) methyltransferase activity | rRNA (uridine-2'-O-)-methyltransferase activity	nucleolus | preribosome, large subunit precursor	Coiled coil | Methyltransferase | Nucleus | Reference proteome | Ribosome biogenesis | rRNA processing | S-adenosyl-L-methionine | Transferase		Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits
Rhipicephalus sanguineus	34632	A0A9D4PL18	Ras-related protein Rac1		192	Unreviewed		actin filament bundle assembly | dorsal appendage formation | hemocyte migration | JNK cascade | lamellipodium assembly | melanotic encapsulation of foreign target | mesodermal cell migration | myoblast fusion | phagocytosis, engulfment | positive regulation of wound healing | regulation of adherens junction organization | regulation of axonogenesis | small GTPase-mediated signal transduction | tracheal outgrowth, open tracheal system	GTP binding | GTPase activity | protein kinase binding		GTP-binding | Lipoprotein | Methylation | Nucleotide-binding | Phagocytosis | Prenylation | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PJ28	(3R)-3-hydroxyacyl-CoA dehydrogenase		253	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PJ27	DNA topoisomerase 2		1612	Unreviewed	Nucleus	DNA topological change | resolution of meiotic recombination intermediates | sister chromatid segregation	ATP binding | DNA binding | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | metal ion binding	nucleus	ATP-binding | DNA-binding | Isomerase | Magnesium | Metal-binding | Nucleotide-binding | Nucleus | Reference proteome | Topoisomerase		Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks
Rhipicephalus sanguineus	34632	A0A9D4PJ11	DNA ligase		912	Unreviewed	Nucleus	DNA biosynthetic process | DNA recombination | double-strand break repair via alternative nonhomologous end joining | lagging strand elongation | mitochondrial DNA repair | negative regulation of DNA metabolic process	ATP binding | DNA binding | DNA ligase (ATP) activity | zinc ion binding	DNA ligase III-XRCC1 complex | mitochondrion | nuclear lumen	ATP-binding | DNA damage | DNA recombination | DNA repair | DNA replication | Ligase | Metal-binding | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Zinc | Zinc-finger		
Rhipicephalus sanguineus	34632	A0A9D4PIZ6	ornithine decarboxylase		475	Unreviewed		putrescine biosynthetic process from arginine, via ornithine	ornithine decarboxylase activity	cytoplasm	Lyase | Polyamine biosynthesis | Pyridoxal phosphate | Reference proteome		Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis
Rhipicephalus sanguineus	34632	A0A9D4PIK5	Multiple inositol polyphosphate phosphatase 1		480	Unreviewed	Cell membrane		acid phosphatase activity | bisphosphoglycerate 3-phosphatase activity | inositol phosphate phosphatase activity	plasma membrane	Cell membrane | Disulfide bond | Glycoprotein | Hydrolase | Membrane | Reference proteome | Signal | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4PI92	RecQ-like DNA helicase BLM		1276	Unreviewed	Nucleus	DNA replication | double-strand break repair via homologous recombination | reciprocal meiotic recombination	3'-5' DNA helicase activity | ATP binding | DNA binding | four-way junction helicase activity | hydrolase activity | metal ion binding	chromosome | cytoplasm | nucleus	ATP-binding | DNA damage | DNA repair | DNA replication | DNA-binding | Helicase | Hydrolase | Isomerase | Metal-binding | Nucleotide-binding | Nucleus | Reference proteome | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4PI42	Adenylyltransferase and sulfurtransferase MOCS3 homolog		429	Unreviewed	Cytoplasm, cytosol	Mo-molybdopterin cofactor biosynthetic process | protein urmylation | tRNA wobble position uridine thiolation	adenylyltransferase activity | ATP binding | metal ion binding | thiosulfate-cyanide sulfurtransferase activity | URM1 activating enzyme activity	cytosol	ATP-binding | Coiled coil | Cytoplasm | Metal-binding | Molybdenum cofactor biosynthesis | Multifunctional enzyme | Nucleotide-binding | Reference proteome | Transferase | tRNA processing | Zinc		Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions
Rhipicephalus sanguineus	34632	A0A9D4PHU3	GTP cyclohydrolase 1		239	Unreviewed		pigment biosynthetic process | tetrahydrobiopterin biosynthetic process | tetrahydrofolate biosynthetic process	GTP binding | GTP cyclohydrolase I activity | zinc ion binding	cytoplasm	GTP-binding | Hydrolase | Nucleotide-binding | Reference proteome | Tetrahydrobiopterin biosynthesis		
Rhipicephalus sanguineus	34632	A0A9D4PHR6	Multiple inositol polyphosphate phosphatase 1		322	Unreviewed	Membrane		acid phosphatase activity | bisphosphoglycerate 3-phosphatase activity | inositol phosphate phosphatase activity	membrane	Hydrolase | Membrane | Reference proteome | Signal		
Rhipicephalus sanguineus	34632	A0A9D4PHP5	(3R)-3-hydroxyacyl-CoA dehydrogenase		253	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PH80	Ribokinase		337	Unreviewed	Cytoplasm | Nucleus	D-ribose catabolic process	ATP binding | metal ion binding | ribokinase activity	cytosol | nucleus	ATP-binding | Carbohydrate metabolism | Cytoplasm | Kinase | Magnesium | Metal-binding | Nucleotide-binding | Nucleus | Potassium | Reference proteome | Transferase		Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Rhipicephalus sanguineus	34632	A0A9D4PGW3	Myosin class i heavy chain		2059	Unreviewed	Cytoplasm	animal organ morphogenesis | signal transduction | system development | tissue development	actin binding | ATP binding | cytoskeletal motor activity | GTPase activator activity	cell periphery | cytoplasm | myosin complex	Actin-binding | ATP-binding | Coiled coil | Cytoplasm | GTPase activation | Motor protein | Myosin | Nucleotide-binding | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PGG2	Glutamate [NMDA] receptor subunit 1		843	Unreviewed	Cell membrane | Postsynaptic cell membrane		ligand-gated monoatomic ion channel activity | signaling receptor activity	postsynaptic membrane	Cell membrane | Disulfide bond | Glycoprotein | Ion channel | Ion transport | Ligand-gated ion channel | Membrane | Phosphoprotein | Postsynaptic cell membrane | Receptor | Reference proteome | Synapse | Transmembrane | Transmembrane helix | Transport		NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation
Rhipicephalus sanguineus	34632	A0A9D4PFW0	Catalase		499	Unreviewed		hydrogen peroxide catabolic process | response to hydrogen peroxide	catalase activity | heme binding | metal ion binding	mitochondrion | peroxisome	Heme | Hydrogen peroxide | Iron | Metal-binding | Oxidoreductase | Peroxidase | Reference proteome		Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide
Rhipicephalus sanguineus	34632	A0A9D4PMZ9	Forkhead box protein O		318	Unreviewed	Cytoplasm | Nucleus	cellular response to oxidative stress | determination of adult lifespan | insulin receptor signaling pathway | negative regulation of multicellular organism growth | positive regulation of catabolic process | positive regulation of defense response | positive regulation of immune response | regulation of lipid storage | response to starvation	DNA-binding transcription activator activity, RNA polymerase II-specific | RNA polymerase II cis-regulatory region sequence-specific DNA binding	cytoplasm | nucleus	Activator | Cell cycle | Cytoplasm | Developmental protein | DNA-binding | Growth regulation | Nucleus | Phosphoprotein | Reference proteome | Transcription | Transcription regulation		
Rhipicephalus sanguineus	34632	A0A9D4PNL8	NAD(P) transhydrogenase, mitochondrial		1085	Unreviewed	Cell inner membrane | Mitochondrion inner membrane	NADPH regeneration	NADP binding | proton-translocating NAD(P)+ transhydrogenase activity	mitochondrial inner membrane | plasma membrane	Acetylation | Cell inner membrane | Cell membrane | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | NADP | Nucleotide-binding | Reference proteome | Transit peptide | Translocase | Transmembrane | Transmembrane helix		The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland
Rhipicephalus sanguineus	34632	A0A9D4PNW4	E3 ubiquitin-protein ligase listerin		1721	Unreviewed		rescue of stalled ribosome | ribosome-associated ubiquitin-dependent protein catabolic process	ribosomal large subunit binding | ubiquitin protein ligase activity | zinc ion binding	cytosol | RQC complex	Metal-binding | Reference proteome | Transferase | Ubl conjugation pathway | Zinc | Zinc-finger		E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation
Rhipicephalus sanguineus	34632	A0A9D4PNY3	RuvB-like helicase		456	Unreviewed	Nucleus	chromatin organization | DNA recombination | DNA repair | positive regulation of gene expression | regulation of canonical Wnt signaling pathway | regulation of cell population proliferation	ATP binding | DNA helicase activity | hydrolase activity | transcription coregulator activity	histone acetyltransferase complex | nucleus	ATP-binding | Chromatin regulator | DNA damage | DNA recombination | DNA repair | Helicase | Hydrolase | Nucleotide-binding | Nucleus | Reference proteome | Transcription | Transcription regulation		Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair
Rhipicephalus sanguineus	34632	A0A9D4PT34	Cyclin-dependent kinase 7		351	Unreviewed	Nucleus	cell division | positive regulation of transcription by RNA polymerase II	ATP binding | cyclin-dependent protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity	cytoplasm | transcription factor TFIIK complex	ATP-binding | Cell cycle | Cell division | Kinase | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4PSR0	Serine/threonine-protein kinase CHK1		488	Unreviewed	Chromosome | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | Nucleus	DNA damage checkpoint signaling | mitotic DNA replication checkpoint signaling	ATP binding | protein serine/threonine kinase activity	centrosome | chromosome | cytoplasm | nucleus	ATP-binding | Cell cycle | Chromosome | Cytoplasm | Cytoskeleton | DNA damage | Kinase | Nucleotide-binding | Nucleus | Phosphoprotein | Reference proteome | Serine/threonine-protein kinase | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4PSK8	CLIP domain-containing serine protease		335	Unreviewed	Endoplasmic reticulum | Golgi apparatus | Secreted	hemostasis | proteolysis	serine-type endopeptidase activity	endoplasmic reticulum | extracellular region | Golgi apparatus	Disulfide bond | Endoplasmic reticulum | Glycoprotein | Golgi apparatus | Hemostasis | Hydrolase | Protease | Reference proteome | Secreted | Serine protease | Signal		Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function
Rhipicephalus sanguineus	34632	A0A9D4PSI0	(3R)-3-hydroxyacyl-CoA dehydrogenase		253	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PRM7	Mothers against decapentaplegic homolog		551	Unreviewed	Cytoplasm | Nucleus	anatomical structure morphogenesis | BMP signaling pathway | cell differentiation | dauer larval development | regulation of developmental process | regulation of multicellular organismal process | SMAD protein signal transduction	DNA-binding transcription factor activity, RNA polymerase II-specific | I-SMAD binding | metal ion binding | RNA polymerase II cis-regulatory region sequence-specific DNA binding	cytoplasm | heteromeric SMAD protein complex	Coiled coil | Cytoplasm | DNA-binding | Metal-binding | Nucleus | Reference proteome | Transcription | Transcription regulation | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4PRJ6	Sodium/potassium-transporting ATPase subunit alpha		1017	Unreviewed	Cell membrane	intracellular potassium ion homeostasis | intracellular sodium ion homeostasis | potassium ion import across plasma membrane | proton transmembrane transport | sodium ion export across plasma membrane	ATP binding | ATP hydrolysis activity | metal ion binding | P-type sodium:potassium-exchanging transporter activity	plasma membrane	ATP-binding | Cell membrane | Ion transport | Membrane | Metal-binding | Nucleotide-binding | Phosphoprotein | Potassium | Potassium transport | Reference proteome | Sodium | Sodium transport | Sodium/potassium transport | Transmembrane | Transmembrane helix | Transport		This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients
Rhipicephalus sanguineus	34632	A0A9D4PRG7	Ferrochelatase, mitochondrial		1214	Unreviewed	Cytoplasm, cytoskeleton	establishment of mitotic spindle localization | heme biosynthetic process | mitotic spindle assembly | regulation of microtubule polymerization or depolymerization | regulation of supramolecular fiber organization	ferrochelatase activity | microtubule binding	basal cortex | cytoplasmic microtubule | kinetochore | microtubule organizing center | mitotic spindle | spindle microtubule	Cytoplasm | Cytoskeleton | Heme biosynthesis | Iron | Lyase | Porphyrin biosynthesis | Reference proteome | Repeat		
Rhipicephalus sanguineus	34632	A0A9D4PRG0	Aminopeptidase		723	Unreviewed	Cell membrane | Membrane	peptide catabolic process | proteolysis	alanyl aminopeptidase activity | metalloaminopeptidase activity | peptide binding | zinc ion binding	cytoplasm | extracellular space | plasma membrane | side of membrane	Aminopeptidase | Cell membrane | Disulfide bond | Glycoprotein | GPI-anchor | Hydrolase | Lipoprotein | Membrane | Metal-binding | Metalloprotease | Protease | Reference proteome | Signal | Transmembrane | Transmembrane helix | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4PRF6	Angiotensin-converting enzyme		464	Unreviewed		proteolysis	carboxypeptidase activity | metal ion binding | metallopeptidase activity | peptidyl-dipeptidase activity	membrane	Carboxypeptidase | Disulfide bond | Glycoprotein | Hydrolase | Metal-binding | Metalloprotease | Protease | Reference proteome | Signal | Zinc		
Rhipicephalus sanguineus	34632	A0A9D4PRF1	Uncharacterized protein		836	Unreviewed	Cytoplasm, cytoskeleton | Membrane	mitochondrial electron transport, succinate to ubiquinone | transport along microtubule | tricarboxylic acid cycle	dynein heavy chain binding | dynein light chain binding | electron transfer activity | metal ion binding	cytoplasmic dynein complex | membrane | mitochondrion	Cytoplasm | Cytoskeleton | Heme | Iron | Membrane | Metal-binding | Reference proteome | Repeat | Transmembrane | Transmembrane helix | WD repeat		
Rhipicephalus sanguineus	34632	A0A9D4PR05	Vitamin K-dependent protein C		366	Unreviewed	Endoplasmic reticulum | Golgi apparatus | Secreted	hemostasis | proteolysis	serine-type endopeptidase activity	endoplasmic reticulum | extracellular region | Golgi apparatus	Disulfide bond | Endoplasmic reticulum | Glycoprotein | Golgi apparatus | Hemostasis | Hydrolase | Protease | Reference proteome | Secreted | Serine protease		Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function
Rhipicephalus sanguineus	34632	A0A9D4PQZ8	Angiotensin-converting enzyme		557	Unreviewed		proteolysis	carboxypeptidase activity | metal ion binding | metallopeptidase activity | peptidyl-dipeptidase activity	membrane	Carboxypeptidase | Disulfide bond | Glycoprotein | Hydrolase | Metal-binding | Metalloprotease | Protease | Reference proteome | Signal | Zinc		
Rhipicephalus sanguineus	34632	A0A2R4H1H9	Cytochrome c oxidase subunit 1	COI	227	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A9D4PF39	Chromatin-remodeling ATPase INO80		373	Unreviewed	Nucleus	chromatin remodeling | DNA repair	ATP binding | ATP hydrolysis activity | DNA binding | histone binding	Ino80 complex	ATP-binding | DNA damage | DNA repair | DNA-binding | Hydrolase | Nucleotide-binding | Reference proteome		ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair
Rhipicephalus sanguineus	34632	A0A9D4PQX1	Aurora kinase		524	Unreviewed	Midbody	chromatin organization | chromosome condensation | cytokinetic process | mitotic sister chromatid segregation	ATP binding | protein serine/threonine kinase activity	midbody	ATP-binding | Kinase | Membrane | Nucleotide-binding | Reference proteome | Serine/threonine-protein kinase | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4PQQ5	N-terminal methionine N(alpha)-acetyltransferase NatE		175	Unreviewed	Cytoplasm	mitotic sister chromatid cohesion	protein N-terminal-methionine acetyltransferase activity	NatA complex	Acyltransferase | Cytoplasm | Reference proteome | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4PQP7	Presenilin		150	Unreviewed	Endoplasmic reticulum membrane | Golgi apparatus membrane	amyloid-beta formation | calcium ion homeostasis | membrane protein ectodomain proteolysis | Notch signaling pathway | protein processing	aspartic endopeptidase activity, intramembrane cleaving	endoplasmic reticulum membrane | gamma-secretase complex | Golgi membrane	Endoplasmic reticulum | Golgi apparatus | Hydrolase | Membrane | Notch signaling pathway | Protease | Reference proteome | Transmembrane | Transmembrane helix		Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors
Rhipicephalus sanguineus	34632	A0A9D4PQH6	N-terminal amino-acid N(alpha)-acetyltransferase NatA		188	Unreviewed			protein N-terminal-serine acetyltransferase activity | protein-N-terminal-glutamate acetyltransferase activity	NatA complex	Acyltransferase | Reference proteome | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4PQ90	Protein phosphatase 1 regulatory subunit 19		346	Unreviewed	Cell projection, dendrite | Cytoplasm | Mitochondrion | Nucleus	negative regulation of transcription by RNA polymerase II	chromatin binding | phosphatase inhibitor activity | transcription corepressor activity	dendrite | mitochondrion | nucleus	Cell projection | Cytoplasm | Mitochondrion | Nucleus | Phosphoprotein | Reference proteome | Repressor | Transcription | Transcription regulation		Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination
Rhipicephalus sanguineus	34632	A0A9D4PQ79	(3R)-3-hydroxyacyl-CoA dehydrogenase		276	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PQ28	(3R)-3-hydroxyacyl-CoA dehydrogenase		254	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PQ12	(3R)-3-hydroxyacyl-CoA dehydrogenase		258	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PPL4	Dihydrolipoyl dehydrogenase		550	Unreviewed		2-oxoglutarate metabolic process | cellular respiration	dihydrolipoyl dehydrogenase (NADH) activity | DNA binding | flavin adenine dinucleotide binding | zinc ion binding	mitochondrion | oxoglutarate dehydrogenase complex | pyruvate dehydrogenase complex	Disulfide bond | DNA-binding | FAD | Flavoprotein | Metal-binding | NAD | Nucleotide-binding | Oxidoreductase | Redox-active center | Reference proteome | Zinc | Zinc-finger		
Rhipicephalus sanguineus	34632	A0A9D4PPK1	Uncharacterized protein		231	Unreviewed	Endomembrane system			endomembrane system | membrane	Membrane | Reference proteome | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4PPH5	Methionine aminopeptidase 2		436	Unreviewed	Cytoplasm	proteolysis	initiator methionyl aminopeptidase activity | metal ion binding | metalloaminopeptidase activity	cytoplasm	Aminopeptidase | Cytoplasm | Hydrolase | Metal-binding | Protease | Reference proteome		Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)
Rhipicephalus sanguineus	34632	A0A9D4PPF9	Tissue-resident T-cell transcription regulator protein ZNF683		967	Unreviewed	Nucleus	adaptive immune response | cell fate commitment | innate immune response | regulation of immune system process | regulation of multicellular organismal process	DNA-binding transcription repressor activity, RNA polymerase II-specific | N-methyltransferase activity | protein methyltransferase activity | RNA polymerase II cis-regulatory region sequence-specific DNA binding | S-adenosylmethionine-dependent methyltransferase activity | zinc ion binding	cytoplasm | nucleus	Adaptive immunity | DNA-binding | Immunity | Innate immunity | Metal-binding | Nucleus | Reference proteome | Repeat | Transcription | Transcription regulation | Zinc | Zinc-finger		
Rhipicephalus sanguineus	34632	A0A9D4PPF0	Pyridoxal kinase		327	Unreviewed		pyridoxal 5'-phosphate salvage	ATP binding | pyridoxal kinase activity	cytosol	ATP-binding | Kinase | Nucleotide-binding | Reference proteome | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4PP56	Small ribosomal subunit protein uS9m		952	Unreviewed	Mitochondrion | Target cell membrane	exocytosis | intracellular signal transduction | translation	structural constituent of ribosome	host cell presynaptic membrane | intracellular organelle lumen | mitochondrial inner membrane | other organism cell membrane | ribonucleoprotein complex | ribosome	ANK repeat | Exocytosis | Membrane | Mitochondrion | Neurotoxin | Presynaptic neurotoxin | Reference proteome | Repeat | Ribonucleoprotein | Ribosomal protein | Target cell membrane | Target membrane | Toxin | Transit peptide		
Rhipicephalus sanguineus	34632	A0A9D4PQR7	(3R)-3-hydroxyacyl-CoA dehydrogenase		540	Unreviewed	Mitochondrion matrix	estrogen metabolic process | fatty acid biosynthetic process	estradiol 17-beta-dehydrogenase [NAD(P)+] activity | quinone binding | testosterone dehydrogenase (NAD+) activity	mitochondrial matrix	Fatty acid biosynthesis | Fatty acid metabolism | Lipid biosynthesis | Lipid metabolism | Mitochondrion | NAD | Oxidoreductase | Phosphoprotein | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PEV1	ATPase ASNA1 homolog		340	Unreviewed	Cytoplasm | Endoplasmic reticulum	tail-anchored membrane protein insertion into ER membrane	ATP binding | ATP hydrolysis activity | metal ion binding	GET complex	ATP-binding | Cytoplasm | Endoplasmic reticulum | Hydrolase | Metal-binding | Nucleotide-binding | Reference proteome | Transport | Zinc		ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting
Rhipicephalus sanguineus	34632	A0A9D4PQX9	DNA repair nuclease/redox regulator APEX1		312	Unreviewed	Nucleus	base-excision repair	DNA binding | DNA-(apurinic or apyrimidinic site) endonuclease activity | double-stranded DNA 3'-5' DNA exonuclease activity | metal ion binding | phosphoric diester hydrolase activity	nucleus	DNA damage | DNA repair | Hydrolase | Magnesium | Manganese | Metal-binding | Nucleus | Reference proteome		
Rhipicephalus sanguineus	34632	A0A9D4PDW9	Delta-like protein		859	Unreviewed	Cell membrane | Membrane	establishment or maintenance of epithelial cell apical/basal polarity | germ-line stem cell population maintenance | gliogenesis | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | lateral inhibition | Notch signaling pathway | second mitotic wave involved in compound eye morphogenesis	calcium ion binding | glycosphingolipid binding | receptor ligand activity	apical cortex | cell surface | plasma membrane | protein-containing complex	Calcium | Cell membrane | Developmental protein | Differentiation | Disulfide bond | EGF-like domain | Glycoprotein | Membrane | Reference proteome | Repeat | Signal | Transmembrane | Transmembrane helix | Ubl conjugation		Putative Notch ligand involved in the mediation of Notch signaling
Rhipicephalus sanguineus	34632	A0A897TCC4	Cytochrome c oxidase subunit 1	COI	245	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A897TAC5	Cytochrome c oxidase subunit 1	COI	250	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A897T8S9	Cytochrome c oxidase subunit 1	COI	253	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A897T787	Cytochrome c oxidase subunit 1	COI	254	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A889ICV8	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A7T8F2Y4	Cytochrome c oxidase subunit 1	COX1	184	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A7S9AUM5	Cytochrome c oxidase subunit 1	COXI	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A7M1DM52	Cytochrome c oxidase subunit 1	COX1	223	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A7M1DM43	Cytochrome c oxidase subunit 1	COX1	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A6M3VXN9	Cytochrome c oxidase subunit 1	COI	178	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A6M3VX68	Cytochrome c oxidase subunit 1	COI	178	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A6M3VVE2	Cytochrome c oxidase subunit 1	COI	178	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A6G9DSR1	Cytochrome c oxidase subunit 1	COX1	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A6B9XY70	Cytochrome c oxidase subunit 1	COX1	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A6B9SCZ1	Cytochrome c oxidase subunit 1	COI	194	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A6B9SCD6	Cytochrome c oxidase subunit 1	COI	196	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A6B9KA75	Cytochrome c oxidase subunit 1	COX1	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A678T9G9	Cytochrome c oxidase subunit 1	COX1	220	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A5P8H8K4	Cytochrome c oxidase subunit 1	cox1	166	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A5P8H7C4	Cytochrome c oxidase subunit 1	cox1	175	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A5P8H7A6	Cytochrome c oxidase subunit 1	cox1	175	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A5B9R2Z6	Cytochrome c oxidase subunit 1	COI	198	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A482K0E8	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A482JXN3	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A386HV51	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A346JF65	Cytochrome c oxidase subunit 1	cox1	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A9D4PEF2	tRNA (guanine-N(7)-)-methyltransferase		248	Unreviewed	Nucleus		tRNA (guanine(46)-N7)-methyltransferase activity | tRNA binding	nucleus | tRNA (m7G46) methyltransferase complex	Membrane | Methyltransferase | Nucleus | Reference proteome | RNA-binding | S-adenosyl-L-methionine | Transferase | Transmembrane | Transmembrane helix | tRNA processing | tRNA-binding		Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
Rhipicephalus sanguineus	34632	A0A8F2EVL8	Cytochrome c oxidase subunit 1	COX1	220	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A8F2EWB1	Cytochrome c oxidase subunit 1	COX1	219	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A482K015	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A8F2FLP6	Cytochrome c oxidase subunit 1	COX1	145	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A8F2FL66	Cytochrome c oxidase subunit 1	COX1	144	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A9D4PDT1	non-specific serine/threonine protein kinase		1027	Unreviewed	Golgi apparatus membrane	meiotic cell cycle | negative regulation of G2/MI transition of meiotic cell cycle | proteolysis	ATP binding | metal ion binding | metalloendopeptidase activity | protein serine/threonine kinase activity	Golgi membrane | nucleus	ATP-binding | Cell cycle | Golgi apparatus | Kinase | Magnesium | Membrane | Metal-binding | Nucleotide-binding | Reference proteome | Serine/threonine-protein kinase | Transferase		
Rhipicephalus sanguineus	34632	A0A9D4PD70	Isocitrate dehydrogenase [NADP]		411	Unreviewed		glyoxylate cycle | isocitrate metabolic process | NADP+ metabolic process | tricarboxylic acid cycle	isocitrate dehydrogenase (NADP+) activity | magnesium ion binding | NAD binding	cytosol | mitochondrion | peroxisome	Glyoxylate bypass | Magnesium | Manganese | Metal-binding | NADP | Oxidoreductase | Reference proteome | Tricarboxylic acid cycle		
Rhipicephalus sanguineus	34632	A0A9D4PCE5	hydroxymethylglutaryl-CoA synthase		1139	Unreviewed	Nucleus	acetyl-CoA metabolic process | farnesyl diphosphate biosynthetic process, mevalonate pathway | regulation of transcription by RNA polymerase II | sterol biosynthetic process	hydroxymethylglutaryl-CoA synthase activity | transcription coregulator activity	mediator complex	Lipid biosynthesis | Lipid metabolism | Nucleus | Reference proteome | Steroid biosynthesis | Steroid metabolism | Sterol biosynthesis | Sterol metabolism | Transcription | Transcription regulation | Transferase		This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase
Rhipicephalus sanguineus	34632	A0A9D4PC93	DNA polymerase eta		789	Unreviewed	Nucleus	DNA repair | error-prone translesion synthesis | response to UV	damaged DNA binding | DNA-directed DNA polymerase activity | zinc ion binding	nucleus | replication fork | site of double-strand break	DNA damage | DNA repair | Magnesium | Metal-binding | Nucleotidyltransferase | Nucleus | Reference proteome | Transferase | Ubl conjugation | Zinc | Zinc-finger		
Rhipicephalus sanguineus	34632	A0A9D4PBX1	Cysteine protease		531	Unreviewed	Cytoplasm	aggrephagy | autophagosome assembly | mitophagy | piecemeal microautophagy of the nucleus | protein processing | protein transport	cysteine-type endopeptidase activity | protein-phosphatidylethanolamide deconjugating activity	cytoplasm	Autophagy | Cytoplasm | Hydrolase | Protease | Protein transport | Reference proteome | Thiol protease | Transport		Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins
Rhipicephalus sanguineus	34632	A0A9D4PBN3	Kynureninase		476	Unreviewed	Cytoplasm	'de novo' NAD+ biosynthetic process from L-tryptophan | anthranilate metabolic process | L-kynurenine catabolic process | L-tryptophan catabolic process to kynurenine | quinolinate biosynthetic process	kynureninase activity | pyridoxal phosphate binding	cytoplasm	Cytoplasm | Hydrolase | Pyridine nucleotide biosynthesis | Pyridoxal phosphate | Reference proteome		Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively
Rhipicephalus sanguineus	34632	A0A9D4PBL3	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like		2247	Unreviewed	Apical cell membrane | Secreted	cell adhesion | cell development | eye morphogenesis | negative regulation of developmental process | negative regulation of multicellular organismal process | neuron differentiation | positive regulation of signal transduction | regionalization | regulation of macromolecule metabolic process | regulation of Notch signaling pathway | regulation of primary metabolic process	calcium ion binding | G protein-coupled receptor activity	apical plasma membrane | extracellular region	Calcium | Cell adhesion | Cell membrane | Developmental protein | Differentiation | Disulfide bond | EGF-like domain | Glycoprotein | Membrane | Phosphoprotein | Reference proteome | Repeat | Secreted | Signal | Sushi | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4PBC7	Kinesin-like protein		667	Unreviewed	Cell projection | Cytoplasm, cytoskeleton	microtubule-based movement | mitotic spindle organization | spindle elongation	ATP binding | microtubule binding | microtubule motor activity	cell projection | microtubule | microtubule associated complex	ATP-binding | Cell projection | Coiled coil | Cytoplasm | Cytoskeleton | Microtubule | Motor protein | Nucleotide-binding | Reference proteome | Repeat | WD repeat		
Rhipicephalus sanguineus	34632	A0A9D4PB59	E3 ubiquitin-protein ligase		306	Unreviewed	Cytoplasm | Nucleus	cell differentiation | proteasome-mediated ubiquitin-dependent protein catabolic process | visual perception	ubiquitin conjugating enzyme binding | ubiquitin protein ligase activity | zinc ion binding	cytoplasm | nucleus	Cytoplasm | Developmental protein | Metal-binding | Nucleus | Reference proteome | Sensory transduction | Transferase | Ubl conjugation pathway | Vision | Zinc | Zinc-finger		E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk). E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cells in the eye, leading to the differentiation of cells into neurons. Also involved in external sensory organ development
Rhipicephalus sanguineus	34632	A0A9D4PB15	E3 ubiquitin-protein ligase		284	Unreviewed		cell differentiation | proteasome-mediated ubiquitin-dependent protein catabolic process | visual perception	ubiquitin conjugating enzyme binding | ubiquitin protein ligase activity | zinc ion binding	cytoplasm	Metal-binding | Reference proteome | Sensory transduction | Transferase | Ubl conjugation pathway | Vision | Zinc | Zinc-finger		E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk). E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cells in the eye, leading to the differentiation of cells into neurons. Also involved in external sensory organ development
Rhipicephalus sanguineus	34632	A0A9D4PAX2	Protein adenylyltransferase Fic		487	Unreviewed	Membrane		AMPylase activity | ATP binding	membrane	ATP-binding | Membrane | Nucleotide-binding | Nucleotidyltransferase | Reference proteome | Repeat | TPR repeat | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4PAK6	medium-chain acyl-CoA ligase		1002	Unreviewed		acyl-CoA metabolic process | fatty acid biosynthetic process | tRNA 3'-terminal CCA addition	ATP binding | fatty-acyl-CoA synthase activity | medium-chain fatty acid-CoA ligase activity | nucleotidyltransferase activity | RNA binding		ATP-binding | Ligase | Membrane | Nucleotide-binding | Reference proteome | RNA-binding | Transferase | Transmembrane | Transmembrane helix		
Rhipicephalus sanguineus	34632	A0A9D4PC66	Protein wntless		529	Unreviewed	Endoplasmic reticulum membrane | Endosome membrane | Golgi apparatus membrane | Postsynaptic cell membrane | Presynaptic cell membrane	intracellular protein transport | Wnt protein secretion | Wnt signaling pathway	Wnt-protein binding	endoplasmic reticulum membrane | endosome membrane | Golgi membrane | postsynaptic membrane | presynaptic membrane	Cell projection | Developmental protein | Golgi apparatus | Membrane | Postsynaptic cell membrane | Reference proteome | Synapse | Transmembrane | Transmembrane helix | Wnt signaling pathway		A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles. Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip
Rhipicephalus sanguineus	34632	A0A9D4P8S5	DNA repair nuclease/redox regulator APEX1		312	Unreviewed	Nucleus	base-excision repair	DNA binding | DNA-(apurinic or apyrimidinic site) endonuclease activity | double-stranded DNA 3'-5' DNA exonuclease activity | metal ion binding | phosphoric diester hydrolase activity	nucleus	DNA damage | DNA repair | Hydrolase | Magnesium | Manganese | Metal-binding | Nucleus | Reference proteome		
Rhipicephalus sanguineus	34632	A0A8F2FM65	Cytochrome c oxidase subunit 1	COX1	145	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A9D4P9K8	Serine/threonine-protein kinase PLK		583	Unreviewed	Cytoplasm	mitotic spindle organization	ATP binding | protein serine/threonine kinase activity	centrosome | cytoplasm | kinetochore | nucleus | spindle pole	ATP-binding | Cytoplasm | Kinase | Nucleotide-binding | Reference proteome | Repeat | Serine/threonine-protein kinase | Transferase		
Rhipicephalus sanguineus	34632	A0A8F2J8L2	Cytochrome c oxidase subunit 1	COX1	221	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A8F2JL28	Cytochrome c oxidase subunit 1	COX1	147	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A8F2JL78	Cytochrome c oxidase subunit 1	COX1	148	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A8F3FH54	Cytochrome c oxidase subunit 1	COX1	154	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A9D4PDU5	Calreticulin		411	Unreviewed	Endoplasmic reticulum lumen	ERAD pathway | protein folding	calcium ion binding | carbohydrate binding | unfolded protein binding	endoplasmic reticulum lumen | endoplasmic reticulum membrane	Calcium | Chaperone | Disulfide bond | Endoplasmic reticulum | Lectin | Metal-binding | Reference proteome | Repeat | Signal | Zinc		Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER
Rhipicephalus sanguineus	34632	A0A8F3FLP8	Cytochrome c oxidase subunit 1	COX1	154	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A8K2APS8	Cytochrome c oxidase subunit 1	COX1	238	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A8F3JB06	Cytochrome c oxidase subunit 1	COX1	154	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A8F3JC81	Cytochrome c oxidase subunit 1	COX1	154	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A8K1KV30	Cytochrome c oxidase subunit 1	COX1	238	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A8K1NNY2	Cytochrome c oxidase subunit 1	COX1	238	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus sanguineus	34632	A0A8F3FHX6	Cytochrome c oxidase subunit 1	COX1	154	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus simus	72861	A0A0U1X5B1	ATP synthase subunit a	ATP6	223	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus simus	72861	Q8HKF2	NADH dehydrogenase subunit 1	ND1	37	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus simus	72861	A0A0U1X5D1	ATP synthase subunit 8	ATP8	52	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus simus	72861	A0A0U1X8L5	Cytochrome c oxidase subunit 2	COX2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus simus	72861	A0A2R4H1C0	Cytochrome c oxidase subunit 1	COI	272	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus simus	72861	A0A0U1X509	NADH-ubiquinone oxidoreductase chain 2	NAD2	318	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus simus	72861	Q9MCZ0	Cytochrome c oxidase subunit 1	COI	264	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus simus	72861	A0A0U1V504	Cytochrome c oxidase subunit 1	COX1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus simus	72861	A0A0U1X550	NADH-ubiquinone oxidoreductase chain 3	NAD3	113	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Rhipicephalus turanicus	34633	A0A343J7Q3	Cytochrome c oxidase subunit 2	COX2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A343J7Q1	NADH-ubiquinone oxidoreductase chain 2	ND2	313	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus turanicus	34633	A0A343J7Q5	ATP synthase subunit a	ATP6	221	Unreviewed	Membrane | Mitochondrion inner membrane		proton-transporting ATP synthase activity, rotational mechanism	mitochondrial inner membrane | proton-transporting ATP synthase complex	ATP synthesis | CF(0) | Hydrogen ion transport | Ion transport | Membrane | Mitochondrion | Transmembrane | Transmembrane helix | Transport		
Rhipicephalus turanicus	34633	A0A343J7P6	Cytochrome c oxidase subunit 2	COX2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A343J7P2	Cytochrome c oxidase subunit 2	COX2	224	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity | oxidoreductase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A291I927	NADH-ubiquinone oxidoreductase chain 1		150	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus turanicus	34633	A0A291I8Z7	NADH-ubiquinone oxidoreductase chain 1		150	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus turanicus	34633	A0A291HGU8	NADH-ubiquinone oxidoreductase chain 2		149	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		
Rhipicephalus turanicus	34633	A0A291HGU2	NADH-ubiquinone oxidoreductase chain 2		149	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		
Rhipicephalus turanicus	34633	A0A1B1QDQ1	Cytochrome c oxidase subunit 1		216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A291HGP0	NADH-ubiquinone oxidoreductase chain 2		149	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		
Rhipicephalus turanicus	34633	A0A291HGN1	NADH-ubiquinone oxidoreductase chain 2		149	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		
Rhipicephalus turanicus	34633	A0A1B1QDU4	Cytochrome c oxidase subunit 1		216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A1B1QDS0	Cytochrome c oxidase subunit 1		216	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A1B1QDR7	Cytochrome c oxidase subunit 1		248	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A1B1QDQ2	Cytochrome c oxidase subunit 1		248	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A343J7Q6	Cytochrome c oxidase subunit 3	COX3	258	Unreviewed	Membrane	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	membrane | mitochondrion	Membrane | Mitochondrion | Translocase | Transmembrane | Transmembrane helix		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A1B1QDP9	Cytochrome c oxidase subunit 1		210	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A291HGQ6	NADH-ubiquinone oxidoreductase chain 2		149	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, NADH to ubiquinone	NADH dehydrogenase (ubiquinone) activity	mitochondrial inner membrane	Electron transport | Membrane | Mitochondrion | Mitochondrion inner membrane | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		
Rhipicephalus turanicus	34633	A0A343J7Q7	NADH-ubiquinone oxidoreductase chain 3	ND3	114	Unreviewed	Membrane | Mitochondrion membrane		NADH dehydrogenase (ubiquinone) activity	mitochondrial membrane | NADH dehydrogenase complex	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Rhipicephalus turanicus	34633	A0A343J7P3	Cytochrome c oxidase subunit I	COX1	14	Unreviewed					Mitochondrion		
Rhipicephalus turanicus	34633	A0A343J7Q9	NADH-ubiquinone oxidoreductase chain 5	ND5	552	Unreviewed	Membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	membrane	Electron transport | Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus turanicus	34633	A0A1B1QDN5	Cytochrome c oxidase subunit 1		248	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A343J7R1	NADH dehydrogenase subunit 4L	ND4L	91	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus turanicus	34633	A0A343J7Q4	ATP synthase F0 subunit 8	ATP8	52	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus turanicus	34633	A0A291HGN0	Cytochrome oxidase subunit 1		9	Unreviewed					Mitochondrion		
Rhipicephalus turanicus	34633	A0A1L6C7F2	Calreticulin		84	Unreviewed	Endoplasmic reticulum	ERAD pathway | protein folding	calcium ion binding | unfolded protein binding	endoplasmic reticulum membrane	Chaperone | Endoplasmic reticulum		
Rhipicephalus turanicus	34633	A0A1L6C7B9	Calreticulin		84	Unreviewed	Endoplasmic reticulum	ERAD pathway | protein folding	calcium ion binding | unfolded protein binding	endoplasmic reticulum membrane	Chaperone | Endoplasmic reticulum		
Rhipicephalus turanicus	34633	A0A1L6C7B8	Calreticulin		84	Unreviewed	Endoplasmic reticulum	ERAD pathway | protein folding	calcium ion binding | unfolded protein binding	endoplasmic reticulum membrane	Chaperone | Endoplasmic reticulum		
Rhipicephalus turanicus	34633	A0A1B1QDP1	Cytochrome c oxidase subunit I		71	Unreviewed					Mitochondrion		
Rhipicephalus turanicus	34633	U5YTL5	Cytochrome c oxidase subunit 1		236	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	U5YTA1	Cytochrome c oxidase subunit 1		236	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	S5MPP3	Cytochrome b	cytB	184	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus turanicus	34633	S5MJD2	Cytochrome b	cytB	208	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus turanicus	34633	S5M5H6	Cytochrome b	cytB	166	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus turanicus	34633	G4WEP3	Cytochrome c oxidase subunit 2	COXII	171	Unreviewed	Mitochondrion inner membrane	ATP synthesis coupled electron transport	copper ion binding | cytochrome-c oxidase activity	mitochondrial inner membrane	Copper | Electron transport | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A6XMX3	Cytochrome c oxidase subunit 1		159	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A7T3PM18	Cytochrome b	cytB	209	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus turanicus	34633	A0A678NZW8	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A343J7R3	Cytochrome b	CYTB	358	Unreviewed	Mitochondrion inner membrane	mitochondrial electron transport, ubiquinol to cytochrome c	metal ion binding | oxidoreductase activity | quinol-cytochrome-c reductase activity	mitochondrial inner membrane | respiratory chain complex III	Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis
Rhipicephalus turanicus	34633	A0A343J7R0	NADH-ubiquinone oxidoreductase chain 4	ND4	435	Unreviewed	Mitochondrion membrane	ATP synthesis coupled electron transport | electron transport coupled proton transport	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity | ubiquinone binding	mitochondrial membrane	Electron transport | Membrane | Mitochondrion | NAD | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus turanicus	34633	A0A343J7Q8	NADH-ubiquinone oxidoreductase chain 1	ND1	313	Unreviewed	Mitochondrion inner membrane | Mitochondrion membrane	aerobic respiration	NADH dehydrogenase (ubiquinone) activity | NADH dehydrogenase activity	mitochondrial inner membrane	Membrane | Mitochondrion | NAD | Transmembrane | Transmembrane helix | Transport | Ubiquinone		Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Rhipicephalus turanicus	34633	A0A1B1QDL8	Cytochrome c oxidase subunit 1		207	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A1S5RSD2	Cytochrome c oxidase subunit 1	COI	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A140GE57	Cytochrome c oxidase subunit 1		281	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A2U8ZUJ9	Cytochrome c oxidase subunit 1	COI	201	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A2I4KEC1	Cytochrome c oxidase subunit 1	COI	204	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A2I4KE79	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A2I4KE74	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A1S5VH63	Cytochrome c oxidase subunit 1	COI	284	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A1S5VH59	Cytochrome c oxidase subunit 1	COI	280	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A1S5VH52	Cytochrome c oxidase subunit 1	COI	287	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A1S5VH51	Cytochrome c oxidase subunit 1	COI	286	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A343J7Q2	Cytochrome c oxidase subunit 1	COX1	512	Unreviewed	Membrane | Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane | respiratory chain complex IV	Copper | Electron transport | Heme | Iron | Magnesium | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A1S5RSD6	Cytochrome c oxidase subunit 1	COI	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A0B4MYM9	Cytochrome c oxidase subunit 1		130	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A0B4MYM0	Cytochrome c oxidase subunit 1		130	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A0B4MYD4	Cytochrome c oxidase subunit 1		130	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A0B4MXQ9	Cytochrome c oxidase subunit 1		130	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A0B4MXJ5	Cytochrome c oxidase subunit 1		130	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A0A0RAN0	Cytochrome c oxidase subunit 1	COI	211	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A0A0R8J4	Cytochrome c oxidase subunit 1	COI	205	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A343J7R2	NADH dehydrogenase subunit 6	ND6	149	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix		
Rhipicephalus turanicus	34633	A0A0G3EH81	Cytochrome c oxidase subunit 1	COX1	175	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A5J6A1R1	Cytochrome c oxidase subunit 1	cox1	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A678PAP2	Cytochrome c oxidase subunit 1	COI	222	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A6C0W6Z2	Cytochrome c oxidase subunit 1	COX1	225	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A0B4MXI8	Cytochrome c oxidase subunit 1		100	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	V5J236	Cytochrome c oxidase subunit 1	COI	235	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	U5N0X7	Cytochrome c oxidase subunit 1	COX1	229	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	U5MXR1	Cytochrome c oxidase subunit 1	COX1	218	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	S5MJC2	Cytochrome c oxidase subunit 1	COX1	228	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	S5M7J9	Cytochrome c oxidase subunit 1	COX1	229	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	Q9MCY9	Cytochrome c oxidase subunit 1	COI	262	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	M1SUX8	Cytochrome c oxidase subunit 1		157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	M1SUX4	Cytochrome c oxidase subunit 1		157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	M1S4X1	Cytochrome c oxidase subunit 1		157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A7H1KNB3	Cytochrome c oxidase subunit 1	COX1	209	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A7G3ZQZ5	Cytochrome c oxidase subunit 1	COX1	223	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A7G3ZQZ4	Cytochrome c oxidase subunit 1	COX1	223	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A6G9HFC8	Cytochrome c oxidase subunit 1	COX1	183	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A6G9HF46	Cytochrome c oxidase subunit 1	COX1	165	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A6G9DTU2	Cytochrome c oxidase subunit 1	COX1	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A6G9DT72	Cytochrome c oxidase subunit 1	COX1	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A6G9DSY0	Cytochrome c oxidase subunit 1	COX1	157	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Signal | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A6G7PSS0	Cytochrome c oxidase subunit 1	COI	214	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	A0A140GE58	Cytochrome c oxidase subunit 1		281	Unreviewed	Mitochondrion inner membrane	electron transport coupled proton transport | mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity | heme binding | metal ion binding	mitochondrial inner membrane	Copper | Electron transport | Heme | Iron | Membrane | Metal-binding | Mitochondrion | Mitochondrion inner membrane | Respiratory chain | Translocase | Transmembrane | Transmembrane helix | Transport		Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Rhipicephalus turanicus	34633	Q8HKF1	NADH dehydrogenase subunit 1	ND1	37	Unreviewed					Membrane | Mitochondrion | Transmembrane | Transmembrane helix