Decaborane

Decaborane



Predicted Absorption properties
PropertyToolInterpretationProbability/Value
Caco-2 permeabilityadmetSAR--
pkCSM-- cm/s
Human Intestinal AbsorptionadmetSAR--
pkCSM-- %
SwissADMEHigh-
Human Oral BioavailabilityadmetSAR--
Log Kp (Skin permeation)pkCSM-- cm/h
SwissADME--6.32 cm/s
Predicted Distribution properties
PropertyToolInterpretationProbability/Value
P-glycoprotein substrateadmetSAR--
pkCSM--
SwissADMENo-
vNNNo Prediction-
P-glycoprotein inhibitoradmetSAR--
vNNNo Prediction-
P-glycoprotein inhibitor IpkCSM--
P-glycoprotein inhibitor IIpkCSM--
Blood Brain BarrieradmetSAR--
pkCSM-- logBB
SwissADMEYes-
vNNNo Prediction-
CNS permeabilitypkCSM-- logPS
Fraction unbound in humanpkCSM--
Plasma protein bindingadmetSAR--
Subcellular localizationadmetSAR--
Steady state volume of distribution (VDss)pkCSM-- L/Kg
Predicted Metabolism properties
PropertyToolInterpretationProbability/Value
CYP1A2 inhibitoradmetSAR-
pkCSM--
SwissADMENo-
vNNNo-
CYP2C19 inhibitoradmetSAR--
pkCSM--
SwissADMENo-
vNNNo-
CYP2C9 inhibitoradmetSAR--
pkCSM--
SwissADMENo-
vNNNo-
CYP2C9 substrateadmetSAR--
CYP2D6 inhibitoradmetSAR--
pkCSM--
SwissADMENo-
vNNNo-
CYP2D6 substrateadmetSAR--
pkCSM--
CYP3A4 inhibitoradmetSAR--
pkCSM--
SwissADMENo-
vNNNo-
CYP3A4 substrateadmetSAR--
pkCSM--
CYP inhibitory promiscuityadmetSAR--
Human Liver Microsomal (HLM) stability assayvNNNo Prediction-
OATP2B1 inhibitoradmetSAR--
OATP1B1 inhibitoradmetSAR--
OATP1B3 inhibitoradmetSAR--
MATE1 inhibitoradmetSAR--
BSEP inhibitoradmetSAR--
UGT catalysisadmetSAR--
Predicted Excretion properties
PropertyToolInterpretationProbability/Value
Renal OCT2 inhibitoradmetSAR--
Renal OCT2 substratepkCSM--
Total clearancepkCSM-- ml/min/kg
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