Hydrogen sulfide

Hydrogen sulfide



Predicted Absorption properties
PropertyToolInterpretationProbability/Value
Caco-2 permeabilityadmetSAR--
pkCSMHigh1.381 cm/s
Human Intestinal AbsorptionadmetSAR--
pkCSMHigh100 %
SwissADMELow-
Human Oral BioavailabilityadmetSAR--
Log Kp (Skin permeation)pkCSMHigh-2.579 cm/h
SwissADME--4.84 cm/s
Predicted Distribution properties
PropertyToolInterpretationProbability/Value
P-glycoprotein substrateadmetSAR--
pkCSMYes-
SwissADMENo-
vNNNo Prediction-
P-glycoprotein inhibitoradmetSAR--
vNNNo Prediction-
P-glycoprotein inhibitor IpkCSMNo-
P-glycoprotein inhibitor IIpkCSMNo-
Blood Brain BarrieradmetSAR--
pkCSMModerate0.035 logBB
SwissADMENo-
vNNNo Prediction-
CNS permeabilitypkCSMModerate-2.298 logPS
Fraction unbound in humanpkCSM-0.785
Plasma protein bindingadmetSAR--
Subcellular localizationadmetSAR--
Steady state volume of distribution (VDss)pkCSMModerate-0.056 L/Kg
Predicted Metabolism properties
PropertyToolInterpretationProbability/Value
CYP1A2 inhibitoradmetSAR-
pkCSMYes-
SwissADMENo-
vNNNo Prediction-
CYP2C19 inhibitoradmetSAR--
pkCSMNo-
SwissADMENo-
vNNNo Prediction-
CYP2C9 inhibitoradmetSAR--
pkCSMNo-
SwissADMENo-
vNNNo Prediction-
CYP2C9 substrateadmetSAR--
CYP2D6 inhibitoradmetSAR--
pkCSMNo-
SwissADMENo-
vNNNo Prediction-
CYP2D6 substrateadmetSAR--
pkCSMNo-
CYP3A4 inhibitoradmetSAR--
pkCSMNo-
SwissADMENo-
vNNNo Prediction-
CYP3A4 substrateadmetSAR--
pkCSMNo-
CYP inhibitory promiscuityadmetSAR--
Human Liver Microsomal (HLM) stability assayvNNNo Prediction-
OATP2B1 inhibitoradmetSAR--
OATP1B1 inhibitoradmetSAR--
OATP1B3 inhibitoradmetSAR--
MATE1 inhibitoradmetSAR--
BSEP inhibitoradmetSAR--
UGT catalysisadmetSAR--
Predicted Excretion properties
PropertyToolInterpretationProbability/Value
Renal OCT2 inhibitoradmetSAR--
Renal OCT2 substratepkCSMNo-
Total clearancepkCSM-0.068 ml/min/kg
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