Prochlorperazine

Prochlorperazine



Predicted Absorption properties
PropertyToolInterpretationProbability/Value
Caco-2 permeabilityadmetSARYes-
pkCSM-- cm/s
Human Intestinal AbsorptionadmetSARYes-
pkCSM-- %
SwissADMEHigh-
Human Oral BioavailabilityadmetSARYes-
Log Kp (Skin permeation)pkCSM-- cm/h
SwissADME--5.12 cm/s
Predicted Distribution properties
PropertyToolInterpretationProbability/Value
P-glycoprotein substrateadmetSARYes-
pkCSM--
SwissADMEYes-
vNNNo-
P-glycoprotein inhibitoradmetSARYes-
vNNNo Prediction-
P-glycoprotein inhibitor IpkCSM--
P-glycoprotein inhibitor IIpkCSM--
Blood Brain BarrieradmetSARYes-
pkCSM-- logBB
SwissADMEYes-
vNNNo Prediction-
CNS permeabilitypkCSM-- logPS
Fraction unbound in humanpkCSM--
Plasma protein bindingadmetSARHigh0.951
Subcellular localizationadmetSARLysosomes-
Steady state volume of distribution (VDss)pkCSM-- L/Kg
Predicted Metabolism properties
PropertyToolInterpretationProbability/Value
CYP1A2 inhibitoradmetSARYes
pkCSM--
SwissADMEYes-
vNNNo Prediction-
CYP2C19 inhibitoradmetSARYes-
pkCSM--
SwissADMENo-
vNNNo Prediction-
CYP2C9 inhibitoradmetSARNo-
pkCSM--
SwissADMENo-
vNNNo Prediction-
CYP2C9 substrateadmetSARNo-
CYP2D6 inhibitoradmetSARYes-
pkCSM--
SwissADMEYes-
vNNNo Prediction-
CYP2D6 substrateadmetSARYes-
pkCSM--
CYP3A4 inhibitoradmetSARNo-
pkCSM--
SwissADMENo-
vNNNo-
CYP3A4 substrateadmetSARYes-
pkCSM--
CYP inhibitory promiscuityadmetSARYes-
Human Liver Microsomal (HLM) stability assayvNNNo Prediction-
OATP2B1 inhibitoradmetSARNo-
OATP1B1 inhibitoradmetSARYes-
OATP1B3 inhibitoradmetSARYes-
MATE1 inhibitoradmetSAR1-
BSEP inhibitoradmetSARYes-
UGT catalysisadmetSARNo-
Predicted Excretion properties
PropertyToolInterpretationProbability/Value
Renal OCT2 inhibitoradmetSARNo-
Renal OCT2 substratepkCSM--
Total clearancepkCSM-- ml/min/kg
Download

DISCLAIMER

NeurotoxKb is a comprehensive knowledgebase of potential environmental neurotoxicants specific to mammals compiled from well-established resources based on the observed neurotoxic endpoints in published literature. The presence of any of the potential neurotoxicants in publicly available chemical compilations, regulatory lists, and guidelines worldwide is reported here solely to support future research on neurotoxicity of environmental chemicals. We do not claim responsibility for any errors or omission in compiled evidence supporting the neurotoxicity of chemicals in our resource, and hence, users are advised to exercise their own informed decision in using the compiled list of potential neurotoxicants in our resource. Further, this work on the compilation of a resource on potential neurotoxicants and their toxicological endpoints is solely based on our scientific understanding of the topic, and this does not necessarily reflect the views or policies of our employers or funders.