Disulfiram

Disulfiram



Chemical nameGene identifierToxCast assay component endpoint name
DisulfiramARACEA_AR_antagonist_80hr
DisulfiramTP53APR_HepG2_p53Act_24h_up
DisulfiramTP53APR_HepG2_p53Act_72h_up
DisulfiramFOSATG_AP_1_CIS_up
DisulfiramJUNATG_AP_1_CIS_up
DisulfiramSMAD1ATG_BRE_CIS_dn
DisulfiramCEBPBATG_C_EBP_CIS_up
DisulfiramCREB3ATG_CRE_CIS_up
DisulfiramNR1H2ATG_DR4_LXR_CIS_dn
DisulfiramNR1H3ATG_DR4_LXR_CIS_dn
DisulfiramRARAATG_DR5_CIS_up
DisulfiramRARBATG_DR5_CIS_up
DisulfiramRARGATG_DR5_CIS_up
DisulfiramUSF1ATG_E_Box_CIS_dn
DisulfiramEGR1ATG_EGR_CIS_up
DisulfiramESR1ATG_ERE_CIS_dn
DisulfiramETS1ATG_Ets_CIS_dn
DisulfiramFOXA2ATG_FoxA2_CIS_dn
DisulfiramFOXO1ATG_FoxO_CIS_dn
DisulfiramFOXO3ATG_FoxO_CIS_dn
DisulfiramGATA1ATG_GATA_CIS_dn
DisulfiramGLI1ATG_GLI_CIS_up
DisulfiramHIF1AATG_HIF1a_CIS_up
DisulfiramONECUT1ATG_HNF6_CIS_dn
DisulfiramHSF1ATG_HSE_CIS_up
DisulfiramNR1H4ATG_IR1_CIS_dn
DisulfiramIRF1ATG_ISRE_CIS_dn
DisulfiramMTF1ATG_MRE_CIS_up
DisulfiramMYBATG_Myb_CIS_dn
DisulfiramMYCATG_Myc_CIS_up
DisulfiramNFIAATG_NFI_CIS_up
DisulfiramNFKB1ATG_NF_kB_CIS_dn
DisulfiramNRF1ATG_NRF1_CIS_dn
DisulfiramNRF1ATG_NRF1_CIS_up
DisulfiramPOU2F1ATG_Oct_MLP_CIS_up
DisulfiramTP53ATG_p53_CIS_dn
DisulfiramPAX6ATG_Pax6_CIS_up
DisulfiramNR1I3ATG_PBREM_CIS_up
DisulfiramNR1I2ATG_PXRE_CIS_dn
DisulfiramNR1I2ATG_PXR_TRANS_up
DisulfiramRARAATG_RARa_TRANS_dn
DisulfiramSOX1ATG_Sox_CIS_up
DisulfiramSP1ATG_Sp1_CIS_up
DisulfiramSREBF1ATG_SREBP_CIS_up
DisulfiramLEF1ATG_TCF_b_cat_CIS_dn
DisulfiramTCF7ATG_TCF_b_cat_CIS_dn
DisulfiramTCF7L1ATG_TCF_b_cat_CIS_dn
DisulfiramTCF7L2ATG_TCF_b_cat_CIS_dn
DisulfiramVDRATG_VDRE_CIS_up
DisulfiramXBP1ATG_Xbp1_CIS_up
DisulfiramSELEBSK_3C_Eselectin_down
DisulfiramHLA-DRABSK_3C_HLADR_down
DisulfiramICAM1BSK_3C_ICAM1_down
DisulfiramCXCL8BSK_3C_IL8_down
DisulfiramCCL2BSK_3C_MCP1_down
DisulfiramCXCL9BSK_3C_MIG_down
DisulfiramTHBDBSK_3C_Thrombomodulin_up
DisulfiramF3BSK_3C_TissueFactor_down
DisulfiramPLAURBSK_3C_uPAR_down
DisulfiramVCAM1BSK_3C_VCAM1_down
DisulfiramCCL26BSK_4H_Eotaxin3_down
DisulfiramCCL2BSK_4H_MCP1_down
DisulfiramSELPBSK_4H_Pselectin_down
DisulfiramPLAURBSK_4H_uPAR_down
DisulfiramVCAM1BSK_4H_VCAM1_down
DisulfiramKDRBSK_4H_VEGFRII_down
DisulfiramHLA-DRABSK_BE3C_HLADR_down
DisulfiramIL1ABSK_BE3C_IL1a_down
DisulfiramCXCL10BSK_BE3C_IP10_down
DisulfiramCXCL9BSK_BE3C_MIG_down
DisulfiramMMP1BSK_BE3C_MMP1_down
DisulfiramSERPINE1BSK_BE3C_PAI1_down
DisulfiramTGFB1BSK_BE3C_TGFb1_down
DisulfiramPLATBSK_BE3C_tPA_down
DisulfiramPLAUBSK_BE3C_uPA_down
DisulfiramPLAURBSK_BE3C_uPAR_down
DisulfiramHLA-DRABSK_CASM3C_HLADR_down
DisulfiramCXCL8BSK_CASM3C_IL8_down
DisulfiramLDLRBSK_CASM3C_LDLR_down
DisulfiramCCL2BSK_CASM3C_MCP1_down
DisulfiramCSF1BSK_CASM3C_MCSF_down
DisulfiramCXCL9BSK_CASM3C_MIG_down
DisulfiramSAA1BSK_CASM3C_SAA_down
DisulfiramTHBDBSK_CASM3C_Thrombomodulin_up
DisulfiramF3BSK_CASM3C_TissueFactor_down
DisulfiramPLAURBSK_CASM3C_uPAR_down
DisulfiramVCAM1BSK_CASM3C_VCAM1_down
DisulfiramCOL3A1BSK_hDFCGF_CollagenIII_down
DisulfiramEGFRBSK_hDFCGF_EGFR_down
DisulfiramCXCL8BSK_hDFCGF_IL8_down
DisulfiramCXCL10BSK_hDFCGF_IP10_down
DisulfiramCSF1BSK_hDFCGF_MCSF_down
DisulfiramCXCL9BSK_hDFCGF_MIG_down
DisulfiramMMP1BSK_hDFCGF_MMP1_down
DisulfiramSERPINE1BSK_hDFCGF_PAI1_down
DisulfiramTIMP1BSK_hDFCGF_TIMP1_down
DisulfiramVCAM1BSK_hDFCGF_VCAM1_down
DisulfiramICAM1BSK_KF3CT_ICAM1_down
DisulfiramIL1ABSK_KF3CT_IL1a_down
DisulfiramCXCL10BSK_KF3CT_IP10_down
DisulfiramCCL2BSK_KF3CT_MCP1_down
DisulfiramMMP9BSK_KF3CT_MMP9_down
DisulfiramTGFB1BSK_KF3CT_TGFb1_down
DisulfiramTIMP2BSK_KF3CT_TIMP2_down
DisulfiramPLAUBSK_KF3CT_uPA_down
DisulfiramCD40BSK_LPS_CD40_down
DisulfiramSELEBSK_LPS_Eselectin_down
DisulfiramIL1ABSK_LPS_IL1a_down
DisulfiramCXCL8BSK_LPS_IL8_down
DisulfiramCCL2BSK_LPS_MCP1_down
DisulfiramCSF1BSK_LPS_MCSF_down
DisulfiramPTGER2BSK_LPS_PGE2_down
DisulfiramF3BSK_LPS_TissueFactor_down
DisulfiramTNFBSK_LPS_TNFa_down
DisulfiramVCAM1BSK_LPS_VCAM1_down
DisulfiramCD38BSK_SAg_CD38_down
DisulfiramCD40BSK_SAg_CD40_down
DisulfiramCD69BSK_SAg_CD69_down
DisulfiramSELEBSK_SAg_Eselectin_down
DisulfiramCXCL8BSK_SAg_IL8_down
DisulfiramCCL2BSK_SAg_MCP1_down
DisulfiramCXCL9BSK_SAg_MIG_down
DisulfiramARCEETOX_H295R_ANDR_dn
DisulfiramCYP19A1NVS_ADME_hCYP19A1
DisulfiramCYP1A2NVS_ADME_hCYP1A2
DisulfiramCYP2B6NVS_ADME_hCYP2B6
DisulfiramCYP2C19NVS_ADME_hCYP2C19
DisulfiramCYP2C9NVS_ADME_hCYP2C9
DisulfiramHTR6NVS_GPCR_h5HT6
DisulfiramHTR7NVS_GPCR_h5HT7
DisulfiramADRB1NVS_GPCR_hAdrb1
DisulfiramDRD1NVS_GPCR_hDRD1
DisulfiramTACR2NVS_GPCR_hNK2
DisulfiramNPY1RNVS_GPCR_hNPY1
DisulfiramOPRL1NVS_GPCR_hORL1
DisulfiramTSPONVS_MP_hPBR
DisulfiramNR1I2NVS_NR_hPXR
DisulfiramSLC29A1NVS_TR_hAdoT
DisulfiramSLC6A3NVS_TR_hDAT
DisulfiramSLC6A2NVS_TR_hNET
DisulfiramAROT_AR_ARSRC1_0480
DisulfiramAROT_AR_ARSRC1_0960
DisulfiramESR1OT_ERa_EREGFP_0120
DisulfiramESR1OT_ERa_EREGFP_0480
DisulfiramESR1OT_ER_ERaERb_1440
DisulfiramESR2OT_ER_ERaERb_1440
DisulfiramJUNTOX21_AP1_BLA_Agonist_ratio
DisulfiramL1RE1TOX21_AP1_BLA_Agonist_ratio
DisulfiramARTOX21_AR_BLA_Agonist_ratio
DisulfiramARTOX21_AR_BLA_Antagonist_ratio
DisulfiramARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
DisulfiramARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
DisulfiramCYP19A1TOX21_Aromatase_Inhibition
DisulfiramNR1I3TOX21_CAR_Antagonist
DisulfiramATAD5TOX21_ELG1_LUC_Agonist
DisulfiramESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
DisulfiramESR2TOX21_ERb_BLA_Antagonist_ratio
DisulfiramESRRATOX21_ERR_Antagonist
DisulfiramNR1H4TOX21_FXR_BLA_antagonist_ratio
DisulfiramHSF1TOX21_HSE_BLA_agonist_ratio
DisulfiramESRRATOX21_PGC_ERR_Antagonist
DisulfiramPPARDTOX21_PPARd_BLA_antagonist_ratio
DisulfiramPGRTOX21_PR_BLA_Antagonist_ratio
DisulfiramTSHRTOX21_TSHR_Agonist_ratio
DisulfiramCYP24A1TOX21_VDR_BLA_antagonist_ratio
DisulfiramVDRTOX21_VDR_BLA_antagonist_ratio

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NeurotoxKb is a comprehensive knowledgebase of potential environmental neurotoxicants specific to mammals compiled from well-established resources based on the observed neurotoxic endpoints in published literature. The presence of any of the potential neurotoxicants in publicly available chemical compilations, regulatory lists, and guidelines worldwide is reported here solely to support future research on neurotoxicity of environmental chemicals. We do not claim responsibility for any errors or omission in compiled evidence supporting the neurotoxicity of chemicals in our resource, and hence, users are advised to exercise their own informed decision in using the compiled list of potential neurotoxicants in our resource. Further, this work on the compilation of a resource on potential neurotoxicants and their toxicological endpoints is solely based on our scientific understanding of the topic, and this does not necessarily reflect the views or policies of our employers or funders.