Fipronil

Fipronil



Chemical nameGene identifierToxCast assay component endpoint name
FipronilARACEA_AR_antagonist_80hr
FipronilFOSATG_AP_1_CIS_up
FipronilJUNATG_AP_1_CIS_up
FipronilSMAD1ATG_BRE_CIS_up
FipronilCEBPBATG_C_EBP_CIS_up
FipronilCREB3ATG_CRE_CIS_up
FipronilNR1H2ATG_DR4_LXR_CIS_dn
FipronilNR1H3ATG_DR4_LXR_CIS_dn
FipronilRARAATG_DR5_CIS_up
FipronilRARBATG_DR5_CIS_up
FipronilRARGATG_DR5_CIS_up
FipronilUSF1ATG_E_Box_CIS_dn
FipronilEGR1ATG_EGR_CIS_up
FipronilESR1ATG_ERa_TRANS_up
FipronilESR1ATG_ERE_CIS_up
FipronilETS1ATG_Ets_CIS_dn
FipronilNR3C1ATG_GRE_CIS_dn
FipronilONECUT1ATG_HNF6_CIS_dn
FipronilHSF1ATG_HSE_CIS_up
FipronilIRF1ATG_ISRE_CIS_dn
FipronilNR1H3ATG_LXRa_TRANS_up
FipronilNR1H2ATG_LXRb_TRANS_up
FipronilMTF1ATG_MRE_CIS_up
FipronilNFKB1ATG_NF_kB_CIS_up
FipronilNFE2L2ATG_NRF2_ARE_CIS_up
FipronilPOU2F1ATG_Oct_MLP_CIS_up
FipronilPAX6ATG_Pax6_CIS_up
FipronilNR1I3ATG_PBREM_CIS_up
FipronilPPARGATG_PPARg_TRANS_up
FipronilPPARAATG_PPRE_CIS_up
FipronilPPARDATG_PPRE_CIS_up
FipronilPPARGATG_PPRE_CIS_up
FipronilNR1I2ATG_PXRE_CIS_up
FipronilNR1I2ATG_PXR_TRANS_up
FipronilRARAATG_RARa_TRANS_up
FipronilRORAATG_RORE_CIS_up
FipronilRORBATG_RORE_CIS_up
FipronilRORCATG_RORE_CIS_up
FipronilSP1ATG_Sp1_CIS_up
FipronilTHRAATG_THRa1_TRANS_up
FipronilVDRATG_VDRE_CIS_up
FipronilXBP1ATG_Xbp1_CIS_up
FipronilSELEBSK_3C_Eselectin_down
FipronilHLA-DRABSK_3C_HLADR_down
FipronilCXCL8BSK_3C_IL8_down
FipronilCCL2BSK_3C_MCP1_down
FipronilPLAURBSK_3C_uPAR_down
FipronilCCL26BSK_4H_Eotaxin3_down
FipronilCCL2BSK_4H_MCP1_down
FipronilSELPBSK_4H_Pselectin_down
FipronilPLAURBSK_4H_uPAR_down
FipronilVCAM1BSK_4H_VCAM1_down
FipronilKDRBSK_4H_VEGFRII_down
FipronilHLA-DRABSK_BE3C_HLADR_down
FipronilCXCL10BSK_BE3C_IP10_down
FipronilCXCL9BSK_BE3C_MIG_down
FipronilSERPINE1BSK_BE3C_PAI1_down
FipronilCSF1BSK_CASM3C_MCSF_down
FipronilTHBDBSK_CASM3C_Thrombomodulin_up
FipronilVCAM1BSK_CASM3C_VCAM1_down
FipronilEGFRBSK_hDFCGF_EGFR_up
FipronilCXCL10BSK_hDFCGF_IP10_down
FipronilCXCL10BSK_KF3CT_IP10_down
FipronilCD40BSK_LPS_CD40_down
FipronilSELEBSK_LPS_Eselectin_down
FipronilCXCL8BSK_LPS_IL8_down
FipronilCCL2BSK_LPS_MCP1_down
FipronilCSF1BSK_LPS_MCSF_down
FipronilTNFBSK_LPS_TNFa_up
FipronilVCAM1BSK_LPS_VCAM1_down
FipronilCD38BSK_SAg_CD38_down
FipronilCD40BSK_SAg_CD40_down
FipronilCD69BSK_SAg_CD69_down
FipronilSELEBSK_SAg_Eselectin_down
FipronilCXCL8BSK_SAg_IL8_down
FipronilCCL2BSK_SAg_MCP1_down
FipronilCXCL9BSK_SAg_MIG_down
FipronilABCB1CLD_ABCB1_48hr
FipronilABCG2CLD_ABCG2_48hr
FipronilCYP2B6CLD_CYP2B6_24hr
FipronilCYP2B6CLD_CYP2B6_48hr
FipronilCYP2B6CLD_CYP2B6_6hr
FipronilCYP3A4CLD_CYP3A4_24hr
FipronilCYP3A4CLD_CYP3A4_48hr
FipronilGSTA2CLD_GSTA2_48hr
FipronilSULT2A1CLD_SULT2A_24hr
FipronilSULT2A1CLD_SULT2A_48hr
FipronilSLC5A5NIS_RAIU_inhibition
FipronilCYP2C19NVS_ADME_hCYP2C19
FipronilCYP2C9NVS_ADME_hCYP2C9
FipronilNR1I3NVS_NR_hCAR_Antagonist
FipronilAROT_AR_ARSRC1_0960
FipronilNR1H4OT_FXR_FXRSRC1_0480
FipronilNR1H4OT_FXR_FXRSRC1_1440
FipronilARTOX21_AR_BLA_Antagonist_ratio
FipronilNFE2L2TOX21_ARE_BLA_agonist_ratio
FipronilARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
FipronilARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
FipronilCYP19A1TOX21_Aromatase_Inhibition
FipronilNR1I3TOX21_CAR_Antagonist
FipronilESR1TOX21_ERa_BLA_Antagonist_ratio
FipronilESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
FipronilESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
FipronilESR2TOX21_ERb_BLA_Antagonist_ratio
FipronilESRRATOX21_ERR_Antagonist
FipronilNR1H4TOX21_FXR_BLA_antagonist_ratio
FipronilNR3C1TOX21_GR_BLA_Antagonist_ratio
FipronilESRRATOX21_PGC_ERR_Antagonist
FipronilPPARDTOX21_PPARd_BLA_antagonist_ratio
FipronilPGRTOX21_PR_BLA_Antagonist_ratio

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NeurotoxKb is a comprehensive knowledgebase of potential environmental neurotoxicants specific to mammals compiled from well-established resources based on the observed neurotoxic endpoints in published literature. The presence of any of the potential neurotoxicants in publicly available chemical compilations, regulatory lists, and guidelines worldwide is reported here solely to support future research on neurotoxicity of environmental chemicals. We do not claim responsibility for any errors or omission in compiled evidence supporting the neurotoxicity of chemicals in our resource, and hence, users are advised to exercise their own informed decision in using the compiled list of potential neurotoxicants in our resource. Further, this work on the compilation of a resource on potential neurotoxicants and their toxicological endpoints is solely based on our scientific understanding of the topic, and this does not necessarily reflect the views or policies of our employers or funders.