Heptachlor

Heptachlor



Chemical nameGene identifierToxCast assay component endpoint name
HeptachlorARACEA_AR_antagonist_80hr
HeptachlorTP53APR_HepG2_p53Act_24h_up
HeptachlorTP53APR_HepG2_p53Act_72h_up
HeptachlorFOSATG_AP_1_CIS_up
HeptachlorJUNATG_AP_1_CIS_up
HeptachlorARATG_AR_TRANS_up
HeptachlorNR1I3ATG_CAR_TRANS_dn
HeptachlorNR1H2ATG_DR4_LXR_CIS_dn
HeptachlorNR1H3ATG_DR4_LXR_CIS_dn
HeptachlorEGR1ATG_EGR_CIS_up
HeptachlorESR1ATG_ERE_CIS_up
HeptachlorESRRAATG_ERRa_TRANS_dn
HeptachlorESRRGATG_ERRg_TRANS_dn
HeptachlorNR1H4ATG_FXR_TRANS_up
HeptachlorNR1H4ATG_IR1_CIS_dn
HeptachlorIRF1ATG_ISRE_CIS_dn
HeptachlorMTF1ATG_MRE_CIS_up
HeptachlorMYCATG_Myc_CIS_up
HeptachlorNFIAATG_NFI_CIS_up
HeptachlorNFKB1ATG_NF_kB_CIS_dn
HeptachlorPOU2F1ATG_Oct_MLP_CIS_up
HeptachlorTP53ATG_p53_CIS_dn
HeptachlorPAX6ATG_Pax6_CIS_up
HeptachlorNR1I2ATG_PXRE_CIS_up
HeptachlorNR1I2ATG_PXR_TRANS_up
HeptachlorRORCATG_RORg_TRANS_dn
HeptachlorSP1ATG_Sp1_CIS_up
HeptachlorSELEBSK_3C_Eselectin_down
HeptachlorHLA-DRABSK_3C_HLADR_down
HeptachlorICAM1BSK_3C_ICAM1_down
HeptachlorCXCL8BSK_3C_IL8_down
HeptachlorCCL2BSK_3C_MCP1_down
HeptachlorCXCL9BSK_3C_MIG_down
HeptachlorF3BSK_3C_TissueFactor_down
HeptachlorPLAURBSK_3C_uPAR_down
HeptachlorVCAM1BSK_3C_VCAM1_down
HeptachlorCCL26BSK_4H_Eotaxin3_down
HeptachlorCCL2BSK_4H_MCP1_down
HeptachlorSELPBSK_4H_Pselectin_down
HeptachlorPLAURBSK_4H_uPAR_down
HeptachlorVCAM1BSK_4H_VCAM1_down
HeptachlorKDRBSK_4H_VEGFRII_down
HeptachlorHLA-DRABSK_BE3C_HLADR_down
HeptachlorIL1ABSK_BE3C_IL1a_down
HeptachlorCXCL10BSK_BE3C_IP10_down
HeptachlorSERPINE1BSK_BE3C_PAI1_down
HeptachlorTGFB1BSK_BE3C_TGFb1_down
HeptachlorPLATBSK_BE3C_tPA_down
HeptachlorHLA-DRABSK_CASM3C_HLADR_down
HeptachlorIL6BSK_CASM3C_IL6_down
HeptachlorCXCL8BSK_CASM3C_IL8_down
HeptachlorLDLRBSK_CASM3C_LDLR_down
HeptachlorCCL2BSK_CASM3C_MCP1_down
HeptachlorCSF1BSK_CASM3C_MCSF_down
HeptachlorCXCL9BSK_CASM3C_MIG_down
HeptachlorSAA1BSK_CASM3C_SAA_down
HeptachlorF3BSK_CASM3C_TissueFactor_down
HeptachlorPLAURBSK_CASM3C_uPAR_down
HeptachlorVCAM1BSK_CASM3C_VCAM1_down
HeptachlorCOL3A1BSK_hDFCGF_CollagenIII_down
HeptachlorCXCL8BSK_hDFCGF_IL8_down
HeptachlorCXCL10BSK_hDFCGF_IP10_down
HeptachlorCSF1BSK_hDFCGF_MCSF_down
HeptachlorCXCL9BSK_hDFCGF_MIG_down
HeptachlorMMP1BSK_hDFCGF_MMP1_down
HeptachlorSERPINE1BSK_hDFCGF_PAI1_down
HeptachlorTIMP1BSK_hDFCGF_TIMP1_down
HeptachlorVCAM1BSK_hDFCGF_VCAM1_down
HeptachlorICAM1BSK_KF3CT_ICAM1_down
HeptachlorIL1ABSK_KF3CT_IL1a_down
HeptachlorCXCL10BSK_KF3CT_IP10_down
HeptachlorCCL2BSK_KF3CT_MCP1_down
HeptachlorMMP9BSK_KF3CT_MMP9_down
HeptachlorTGFB1BSK_KF3CT_TGFb1_down
HeptachlorTIMP2BSK_KF3CT_TIMP2_down
HeptachlorPLAUBSK_KF3CT_uPA_down
HeptachlorCD40BSK_LPS_CD40_down
HeptachlorSELEBSK_LPS_Eselectin_down
HeptachlorIL1ABSK_LPS_IL1a_down
HeptachlorCXCL8BSK_LPS_IL8_down
HeptachlorCCL2BSK_LPS_MCP1_down
HeptachlorCSF1BSK_LPS_MCSF_down
HeptachlorF3BSK_LPS_TissueFactor_down
HeptachlorTNFBSK_LPS_TNFa_down
HeptachlorVCAM1BSK_LPS_VCAM1_down
HeptachlorCD38BSK_SAg_CD38_down
HeptachlorCD40BSK_SAg_CD40_down
HeptachlorCD69BSK_SAg_CD69_down
HeptachlorSELEBSK_SAg_Eselectin_down
HeptachlorCXCL8BSK_SAg_IL8_down
HeptachlorCCL2BSK_SAg_MCP1_down
HeptachlorCXCL9BSK_SAg_MIG_down
HeptachlorSLC5A5NIS_RAIU_inhibition
HeptachlorAROT_AR_ARSRC1_0480
HeptachlorAROT_AR_ARSRC1_0960
HeptachlorNR1H4OT_FXR_FXRSRC1_0480
HeptachlorRXRAOT_NURR1_NURR1RXRa_0480
HeptachlorJUNTOX21_AP1_BLA_Agonist_ratio
HeptachlorL1RE1TOX21_AP1_BLA_Agonist_ratio
HeptachlorARTOX21_AR_BLA_Agonist_ratio
HeptachlorNFE2L2TOX21_ARE_BLA_agonist_ratio
HeptachlorARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
HeptachlorCYP19A1TOX21_Aromatase_Inhibition
HeptachlorNR1I3TOX21_CAR_Agonist
HeptachlorESR2TOX21_ERb_BLA_Antagonist_ratio
HeptachlorESRRATOX21_ERR_Antagonist
HeptachlorATF6TOX21_ESRE_BLA_ratio
HeptachlorNR1H4TOX21_FXR_BLA_antagonist_ratio
HeptachlorNR3C1TOX21_GR_BLA_Agonist_ratio
HeptachlorHIF1ATOX21_HRE_BLA_Agonist_ratio
HeptachlorNFKB1TOX21_NFkB_BLA_agonist_ratio
HeptachlorTP53TOX21_p53_BLA_p1_ratio
HeptachlorPGRTOX21_PR_BLA_Antagonist_ratio
HeptachlorTSHRTOX21_TSHR_Agonist_ratio

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NeurotoxKb is a comprehensive knowledgebase of potential environmental neurotoxicants specific to mammals compiled from well-established resources based on the observed neurotoxic endpoints in published literature. The presence of any of the potential neurotoxicants in publicly available chemical compilations, regulatory lists, and guidelines worldwide is reported here solely to support future research on neurotoxicity of environmental chemicals. We do not claim responsibility for any errors or omission in compiled evidence supporting the neurotoxicity of chemicals in our resource, and hence, users are advised to exercise their own informed decision in using the compiled list of potential neurotoxicants in our resource. Further, this work on the compilation of a resource on potential neurotoxicants and their toxicological endpoints is solely based on our scientific understanding of the topic, and this does not necessarily reflect the views or policies of our employers or funders.