Hexachlorophene

Hexachlorophene



Chemical nameGene identifierToxCast assay component endpoint name
HexachloropheneAHRATG_Ahr_CIS_up
HexachloropheneTFAP2AATG_AP_2_CIS_dn
HexachloropheneTFAP2BATG_AP_2_CIS_dn
HexachloropheneTFAP2DATG_AP_2_CIS_dn
HexachloropheneSMAD1ATG_BRE_CIS_up
HexachloropheneCEBPBATG_C_EBP_CIS_up
HexachloropheneNR1H2ATG_DR4_LXR_CIS_dn
HexachloropheneNR1H3ATG_DR4_LXR_CIS_dn
HexachloropheneRARAATG_DR5_CIS_up
HexachloropheneRARBATG_DR5_CIS_up
HexachloropheneRARGATG_DR5_CIS_up
HexachloropheneEGR1ATG_EGR_CIS_up
HexachloropheneETS1ATG_Ets_CIS_dn
HexachloropheneNR1H4ATG_FXR_TRANS_up
HexachloropheneHIF1AATG_HIF1a_CIS_up
HexachloropheneHNF4AATG_HNF4a_TRANS_up
HexachloropheneHSF1ATG_HSE_CIS_up
HexachloropheneIRF1ATG_ISRE_CIS_dn
HexachloropheneMTF1ATG_MRE_CIS_up
HexachloropheneMYCATG_Myc_CIS_dn
HexachloropheneNFE2L2ATG_NRF2_ARE_CIS_up
HexachloropheneNR4A2ATG_NURR1_TRANS_up
HexachlorophenePOU2F1ATG_Oct_MLP_CIS_up
HexachloropheneTP53ATG_p53_CIS_dn
HexachlorophenePAX6ATG_Pax6_CIS_up
HexachloropheneNR1I3ATG_PBREM_CIS_up
HexachlorophenePPARAATG_PPARa_TRANS_up
HexachlorophenePPARGATG_PPARg_TRANS_up
HexachlorophenePPARAATG_PPRE_CIS_up
HexachlorophenePPARDATG_PPRE_CIS_up
HexachlorophenePPARGATG_PPRE_CIS_up
HexachloropheneNR1I2ATG_PXRE_CIS_up
HexachloropheneNR1I2ATG_PXR_TRANS_up
HexachloropheneRORAATG_RORE_CIS_up
HexachloropheneRORBATG_RORE_CIS_up
HexachloropheneRORCATG_RORE_CIS_up
HexachloropheneRXRBATG_RXRb_TRANS_up
HexachloropheneLEF1ATG_TCF_b_cat_CIS_dn
HexachloropheneTCF7ATG_TCF_b_cat_CIS_dn
HexachloropheneTCF7L1ATG_TCF_b_cat_CIS_dn
HexachloropheneTCF7L2ATG_TCF_b_cat_CIS_dn
HexachloropheneTHRAATG_THRa1_TRANS_up
HexachloropheneVDRATG_VDRE_CIS_up
HexachloropheneSELEBSK_3C_Eselectin_down
HexachloropheneHLA-DRABSK_3C_HLADR_down
HexachloropheneICAM1BSK_3C_ICAM1_down
HexachloropheneCXCL8BSK_3C_IL8_down
HexachloropheneCCL2BSK_3C_MCP1_down
HexachloropheneCXCL9BSK_3C_MIG_down
HexachloropheneF3BSK_3C_TissueFactor_down
HexachlorophenePLAURBSK_3C_uPAR_down
HexachloropheneVCAM1BSK_3C_VCAM1_down
HexachloropheneCCL26BSK_4H_Eotaxin3_down
HexachloropheneCCL2BSK_4H_MCP1_down
HexachloropheneSELPBSK_4H_Pselectin_down
HexachlorophenePLAURBSK_4H_uPAR_down
HexachloropheneVCAM1BSK_4H_VCAM1_down
HexachloropheneKDRBSK_4H_VEGFRII_down
HexachloropheneHLA-DRABSK_BE3C_HLADR_down
HexachloropheneIL1ABSK_BE3C_IL1a_down
HexachloropheneCXCL10BSK_BE3C_IP10_down
HexachloropheneCXCL9BSK_BE3C_MIG_down
HexachloropheneMMP1BSK_BE3C_MMP1_down
HexachloropheneSERPINE1BSK_BE3C_PAI1_down
HexachloropheneTGFB1BSK_BE3C_TGFb1_down
HexachlorophenePLATBSK_BE3C_tPA_down
HexachlorophenePLAUBSK_BE3C_uPA_down
HexachlorophenePLAURBSK_BE3C_uPAR_down
HexachloropheneHLA-DRABSK_CASM3C_HLADR_down
HexachloropheneIL6BSK_CASM3C_IL6_down
HexachloropheneCCL2BSK_CASM3C_MCP1_down
HexachloropheneCSF1BSK_CASM3C_MCSF_down
HexachloropheneCXCL9BSK_CASM3C_MIG_down
HexachloropheneSAA1BSK_CASM3C_SAA_down
HexachloropheneF3BSK_CASM3C_TissueFactor_down
HexachlorophenePLAURBSK_CASM3C_uPAR_down
HexachloropheneVCAM1BSK_CASM3C_VCAM1_down
HexachloropheneCOL3A1BSK_hDFCGF_CollagenIII_down
HexachloropheneEGFRBSK_hDFCGF_EGFR_down
HexachloropheneCXCL8BSK_hDFCGF_IL8_down
HexachloropheneCXCL10BSK_hDFCGF_IP10_down
HexachloropheneCSF1BSK_hDFCGF_MCSF_down
HexachloropheneCXCL9BSK_hDFCGF_MIG_down
HexachloropheneMMP1BSK_hDFCGF_MMP1_down
HexachloropheneSERPINE1BSK_hDFCGF_PAI1_down
HexachloropheneTIMP1BSK_hDFCGF_TIMP1_down
HexachloropheneVCAM1BSK_hDFCGF_VCAM1_down
HexachloropheneICAM1BSK_KF3CT_ICAM1_down
HexachloropheneIL1ABSK_KF3CT_IL1a_down
HexachloropheneCXCL10BSK_KF3CT_IP10_down
HexachloropheneCCL2BSK_KF3CT_MCP1_down
HexachloropheneMMP9BSK_KF3CT_MMP9_down
HexachloropheneTGFB1BSK_KF3CT_TGFb1_down
HexachloropheneTIMP2BSK_KF3CT_TIMP2_down
HexachlorophenePLAUBSK_KF3CT_uPA_down
HexachloropheneCD40BSK_LPS_CD40_down
HexachloropheneSELEBSK_LPS_Eselectin_down
HexachloropheneIL1ABSK_LPS_IL1a_down
HexachloropheneCXCL8BSK_LPS_IL8_down
HexachloropheneCCL2BSK_LPS_MCP1_down
HexachloropheneCSF1BSK_LPS_MCSF_down
HexachloropheneF3BSK_LPS_TissueFactor_down
HexachloropheneTNFBSK_LPS_TNFa_down
HexachloropheneVCAM1BSK_LPS_VCAM1_down
HexachloropheneCD38BSK_SAg_CD38_down
HexachloropheneCD40BSK_SAg_CD40_down
HexachloropheneCD69BSK_SAg_CD69_down
HexachloropheneSELEBSK_SAg_Eselectin_down
HexachloropheneCXCL8BSK_SAg_IL8_down
HexachloropheneCCL2BSK_SAg_MCP1_down
HexachloropheneCXCL9BSK_SAg_MIG_down
HexachloropheneBACE1NVS_ENZ_hBACE
HexachloropheneCASP5NVS_ENZ_hCASP5
HexachlorophenePIK3CANVS_ENZ_hPI3Ka
HexachloropheneFLT1NVS_ENZ_hVEGFR1
HexachloropheneADORA2ANVS_GPCR_hAdoRA2a
HexachloropheneOPRM1NVS_GPCR_hOpiate_mu
HexachloropheneARNVS_NR_hAR
HexachloropheneESR1NVS_NR_hER
HexachloropheneNR3C1NVS_NR_hGR
HexachloropheneARTOX21_AR_BLA_Antagonist_ratio
HexachloropheneARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
HexachloropheneARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
HexachloropheneCYP19A1TOX21_Aromatase_Inhibition
HexachloropheneNR1I3TOX21_CAR_Antagonist
HexachloropheneESR1TOX21_ERa_BLA_Antagonist_ratio
HexachloropheneESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
HexachloropheneESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
HexachloropheneESR2TOX21_ERb_BLA_Antagonist_ratio
HexachloropheneESRRATOX21_ERR_Antagonist
HexachloropheneATF6TOX21_ESRE_BLA_ratio
HexachloropheneNR1H4TOX21_FXR_BLA_antagonist_ratio
HexachloropheneNR3C1TOX21_GR_BLA_Agonist_ratio
HexachloropheneHIF1ATOX21_HRE_BLA_Agonist_ratio
HexachloropheneHSF1TOX21_HSE_BLA_agonist_ratio
HexachloropheneTP53TOX21_p53_BLA_p1_ratio
HexachloropheneTP53TOX21_p53_BLA_p2_ratio
HexachloropheneTP53TOX21_p53_BLA_p3_ratio
HexachloropheneTP53TOX21_p53_BLA_p4_ratio
HexachloropheneTP53TOX21_p53_BLA_p5_ratio
HexachloropheneESRRATOX21_PGC_ERR_Antagonist
HexachlorophenePPARDTOX21_PPARd_BLA_agonist_ratio
HexachlorophenePPARGTOX21_PPARg_BLA_Agonist_ratio
HexachlorophenePPARGTOX21_PPARg_BLA_antagonist_ratio
HexachlorophenePGRTOX21_PR_BLA_Antagonist_ratio
HexachloropheneCYP24A1TOX21_VDR_BLA_agonist_ratio
HexachloropheneVDRTOX21_VDR_BLA_agonist_ratio
HexachloropheneCYP24A1TOX21_VDR_BLA_antagonist_ratio
HexachloropheneVDRTOX21_VDR_BLA_antagonist_ratio

DISCLAIMER

NeurotoxKb is a comprehensive knowledgebase of potential environmental neurotoxicants specific to mammals compiled from well-established resources based on the observed neurotoxic endpoints in published literature. The presence of any of the potential neurotoxicants in publicly available chemical compilations, regulatory lists, and guidelines worldwide is reported here solely to support future research on neurotoxicity of environmental chemicals. We do not claim responsibility for any errors or omission in compiled evidence supporting the neurotoxicity of chemicals in our resource, and hence, users are advised to exercise their own informed decision in using the compiled list of potential neurotoxicants in our resource. Further, this work on the compilation of a resource on potential neurotoxicants and their toxicological endpoints is solely based on our scientific understanding of the topic, and this does not necessarily reflect the views or policies of our employers or funders.