Amitraz

Amitraz



Chemical nameGene identifierToxCast assay component endpoint name
AmitrazARACEA_AR_antagonist_80hr
AmitrazRARAATG_DR5_CIS_dn
AmitrazRARBATG_DR5_CIS_dn
AmitrazRARGATG_DR5_CIS_dn
AmitrazFOXO1ATG_FoxO_CIS_up
AmitrazFOXO3ATG_FoxO_CIS_up
AmitrazMYBATG_Myb_CIS_up
AmitrazPOU2F1ATG_Oct_MLP_CIS_up
AmitrazNR1I2ATG_PXRE_CIS_dn
AmitrazSELEBSK_3C_Eselectin_down
AmitrazHLA-DRABSK_3C_HLADR_down
AmitrazICAM1BSK_3C_ICAM1_down
AmitrazCXCL8BSK_3C_IL8_down
AmitrazCCL2BSK_3C_MCP1_down
AmitrazCXCL9BSK_3C_MIG_down
AmitrazTHBDBSK_3C_Thrombomodulin_up
AmitrazF3BSK_3C_TissueFactor_down
AmitrazPLAURBSK_3C_uPAR_down
AmitrazVCAM1BSK_3C_VCAM1_down
AmitrazCCL26BSK_4H_Eotaxin3_down
AmitrazCCL2BSK_4H_MCP1_down
AmitrazSELPBSK_4H_Pselectin_down
AmitrazPLAURBSK_4H_uPAR_down
AmitrazVCAM1BSK_4H_VCAM1_down
AmitrazKDRBSK_4H_VEGFRII_down
AmitrazHLA-DRABSK_BE3C_HLADR_down
AmitrazIL1ABSK_BE3C_IL1a_down
AmitrazCXCL10BSK_BE3C_IP10_down
AmitrazCXCL9BSK_BE3C_MIG_down
AmitrazSERPINE1BSK_BE3C_PAI1_down
AmitrazTGFB1BSK_BE3C_TGFb1_down
AmitrazPLAURBSK_BE3C_uPAR_down
AmitrazIL6BSK_CASM3C_IL6_up
AmitrazCSF1BSK_CASM3C_MCSF_down
AmitrazSAA1BSK_CASM3C_SAA_down
AmitrazTHBDBSK_CASM3C_Thrombomodulin_up
AmitrazVCAM1BSK_CASM3C_VCAM1_up
AmitrazCOL3A1BSK_hDFCGF_CollagenIII_down
AmitrazCXCL8BSK_hDFCGF_IL8_down
AmitrazCXCL10BSK_hDFCGF_IP10_down
AmitrazCSF1BSK_hDFCGF_MCSF_down
AmitrazCXCL9BSK_hDFCGF_MIG_down
AmitrazMMP1BSK_hDFCGF_MMP1_down
AmitrazSERPINE1BSK_hDFCGF_PAI1_down
AmitrazTIMP1BSK_hDFCGF_TIMP1_down
AmitrazVCAM1BSK_hDFCGF_VCAM1_down
AmitrazCXCL10BSK_KF3CT_IP10_down
AmitrazMMP9BSK_KF3CT_MMP9_down
AmitrazTIMP2BSK_KF3CT_TIMP2_down
AmitrazPLAUBSK_KF3CT_uPA_down
AmitrazCD40BSK_LPS_CD40_down
AmitrazSELEBSK_LPS_Eselectin_down
AmitrazIL1ABSK_LPS_IL1a_down
AmitrazCXCL8BSK_LPS_IL8_down
AmitrazCCL2BSK_LPS_MCP1_down
AmitrazCSF1BSK_LPS_MCSF_down
AmitrazPTGER2BSK_LPS_PGE2_down
AmitrazF3BSK_LPS_TissueFactor_down
AmitrazTNFBSK_LPS_TNFa_down
AmitrazVCAM1BSK_LPS_VCAM1_down
AmitrazCD38BSK_SAg_CD38_down
AmitrazCD40BSK_SAg_CD40_down
AmitrazCD69BSK_SAg_CD69_down
AmitrazSELEBSK_SAg_Eselectin_down
AmitrazCCL2BSK_SAg_MCP1_down
AmitrazCXCL9BSK_SAg_MIG_down
AmitrazABCB1CLD_ABCB1_24hr
AmitrazABCG2CLD_ABCG2_24hr
AmitrazABCG2CLD_ABCG2_48hr
AmitrazCYP1A1CLD_CYP1A1_48hr
AmitrazCYP1A2CLD_CYP1A2_48hr
AmitrazSLC5A5NIS_RAIU_inhibition
AmitrazCYP2C19NVS_ADME_hCYP2C19
AmitrazPTPN11NVS_ENZ_hPTPN11_Activator
AmitrazHTR7NVS_GPCR_h5HT7
AmitrazADRA2ANVS_GPCR_hAdra2A
AmitrazAROT_AR_ARSRC1_0960
AmitrazNR1H4OT_FXR_FXRSRC1_0480
AmitrazRXRAOT_NURR1_NURR1RXRa_0480
AmitrazRXRAOT_NURR1_NURR1RXRa_1440
AmitrazAHRTOX21_AhR_LUC_Agonist
AmitrazJUNTOX21_AP1_BLA_Agonist_ratio
AmitrazL1RE1TOX21_AP1_BLA_Agonist_ratio
AmitrazARTOX21_AR_BLA_Antagonist_ratio
AmitrazARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
AmitrazCYP19A1TOX21_Aromatase_Inhibition
AmitrazNR1I3TOX21_CAR_Antagonist
AmitrazESRRATOX21_ERR_Antagonist
AmitrazNR1H4TOX21_FXR_BLA_antagonist_ratio
AmitrazHIF1ATOX21_HRE_BLA_Agonist_ratio
AmitrazESRRATOX21_PGC_ERR_Antagonist

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NeurotoxKb is a comprehensive knowledgebase of potential environmental neurotoxicants specific to mammals compiled from well-established resources based on the observed neurotoxic endpoints in published literature. The presence of any of the potential neurotoxicants in publicly available chemical compilations, regulatory lists, and guidelines worldwide is reported here solely to support future research on neurotoxicity of environmental chemicals. We do not claim responsibility for any errors or omission in compiled evidence supporting the neurotoxicity of chemicals in our resource, and hence, users are advised to exercise their own informed decision in using the compiled list of potential neurotoxicants in our resource. Further, this work on the compilation of a resource on potential neurotoxicants and their toxicological endpoints is solely based on our scientific understanding of the topic, and this does not necessarily reflect the views or policies of our employers or funders.