Dinoseb

Dinoseb



Chemical nameGene identifierToxCast assay component endpoint name
DinosebARACEA_AR_antagonist_80hr
DinosebTP53APR_HepG2_p53Act_72h_up
DinosebFOSATG_AP_1_CIS_up
DinosebJUNATG_AP_1_CIS_up
DinosebSMAD1ATG_BRE_CIS_up
DinosebCEBPBATG_C_EBP_CIS_up
DinosebCREB3ATG_CRE_CIS_up
DinosebRARAATG_DR5_CIS_up
DinosebRARBATG_DR5_CIS_up
DinosebRARGATG_DR5_CIS_up
DinosebEGR1ATG_EGR_CIS_up
DinosebESR1ATG_ERa_TRANS_up
DinosebETS1ATG_Ets_CIS_dn
DinosebHIF1AATG_HIF1a_CIS_up
DinosebHSF1ATG_HSE_CIS_up
DinosebIRF1ATG_ISRE_CIS_dn
DinosebNR1H3ATG_LXRa_TRANS_up
DinosebNR1H2ATG_LXRb_TRANS_up
DinosebMTF1ATG_MRE_CIS_up
DinosebMYBATG_Myb_CIS_dn
DinosebNFE2L2ATG_NRF2_ARE_CIS_up
DinosebPOU2F1ATG_Oct_MLP_CIS_up
DinosebPAX6ATG_Pax6_CIS_up
DinosebNR1I3ATG_PBREM_CIS_up
DinosebPPARAATG_PPARa_TRANS_up
DinosebPPARGATG_PPARg_TRANS_up
DinosebPPARAATG_PPRE_CIS_up
DinosebPPARDATG_PPRE_CIS_up
DinosebPPARGATG_PPRE_CIS_up
DinosebNR1I2ATG_PXR_TRANS_up
DinosebRORAATG_RORE_CIS_up
DinosebRORBATG_RORE_CIS_up
DinosebRORCATG_RORE_CIS_up
DinosebRXRBATG_RXRb_TRANS_up
DinosebSOX1ATG_Sox_CIS_up
DinosebSP1ATG_Sp1_CIS_up
DinosebSREBF1ATG_SREBP_CIS_up
DinosebTHRAATG_THRa1_TRANS_up
DinosebVDRATG_VDRE_CIS_up
DinosebXBP1ATG_Xbp1_CIS_up
DinosebSELEBSK_3C_Eselectin_down
DinosebHLA-DRABSK_3C_HLADR_down
DinosebCXCL8BSK_3C_IL8_down
DinosebCCL2BSK_3C_MCP1_down
DinosebPLAURBSK_3C_uPAR_down
DinosebVCAM1BSK_3C_VCAM1_down
DinosebCCL26BSK_4H_Eotaxin3_down
DinosebCCL2BSK_4H_MCP1_down
DinosebSELPBSK_4H_Pselectin_down
DinosebPLAURBSK_4H_uPAR_down
DinosebVCAM1BSK_4H_VCAM1_down
DinosebKDRBSK_4H_VEGFRII_down
DinosebHLA-DRABSK_BE3C_HLADR_down
DinosebCXCL10BSK_BE3C_IP10_down
DinosebMMP1BSK_BE3C_MMP1_down
DinosebSERPINE1BSK_BE3C_PAI1_down
DinosebTGFB1BSK_BE3C_TGFb1_down
DinosebPLATBSK_BE3C_tPA_down
DinosebPLAUBSK_BE3C_uPA_down
DinosebHLA-DRABSK_CASM3C_HLADR_down
DinosebLDLRBSK_CASM3C_LDLR_down
DinosebPLAURBSK_CASM3C_uPAR_down
DinosebCXCL10BSK_hDFCGF_IP10_down
DinosebCSF1BSK_hDFCGF_MCSF_down
DinosebSERPINE1BSK_hDFCGF_PAI1_down
DinosebCCL2BSK_KF3CT_MCP1_up
DinosebMMP9BSK_KF3CT_MMP9_down
DinosebCD40BSK_LPS_CD40_down
DinosebSELEBSK_LPS_Eselectin_down
DinosebIL1ABSK_LPS_IL1a_down
DinosebCXCL8BSK_LPS_IL8_down
DinosebCCL2BSK_LPS_MCP1_down
DinosebCSF1BSK_LPS_MCSF_down
DinosebPTGER2BSK_LPS_PGE2_down
DinosebVCAM1BSK_LPS_VCAM1_down
DinosebCD38BSK_SAg_CD38_down
DinosebCD40BSK_SAg_CD40_down
DinosebCD69BSK_SAg_CD69_down
DinosebSELEBSK_SAg_Eselectin_down
DinosebCXCL8BSK_SAg_IL8_down
DinosebCCL2BSK_SAg_MCP1_down
DinosebCXCL9BSK_SAg_MIG_down
DinosebSLC5A5NIS_RAIU_inhibition
DinosebCYP2C19NVS_ADME_hCYP2C19
DinosebCSNK1DNVS_ENZ_hCK1D
DinosebPTPRCNVS_ENZ_hPTPRC
DinosebAROT_AR_ARSRC1_0960
DinosebARTOX21_AR_BLA_Antagonist_ratio
DinosebNFE2L2TOX21_ARE_BLA_agonist_ratio
DinosebARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
DinosebARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
DinosebCYP19A1TOX21_Aromatase_Inhibition
DinosebNR1I3TOX21_CAR_Antagonist
DinosebESR1TOX21_ERa_BLA_Antagonist_ratio
DinosebESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
DinosebESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
DinosebESR2TOX21_ERb_BLA_Antagonist_ratio
DinosebESRRATOX21_ERR_Antagonist
DinosebNR1H4TOX21_FXR_BLA_antagonist_ratio
DinosebTP53TOX21_p53_BLA_p2_ratio
DinosebTP53TOX21_p53_BLA_p3_ratio
DinosebTP53TOX21_p53_BLA_p4_ratio
DinosebTP53TOX21_p53_BLA_p5_ratio
DinosebESRRATOX21_PGC_ERR_Antagonist
DinosebPPARDTOX21_PPARd_BLA_agonist_ratio
DinosebPPARGTOX21_PPARg_BLA_antagonist_ratio
DinosebPGRTOX21_PR_BLA_Antagonist_ratio

DISCLAIMER

NeurotoxKb is a comprehensive knowledgebase of potential environmental neurotoxicants specific to mammals compiled from well-established resources based on the observed neurotoxic endpoints in published literature. The presence of any of the potential neurotoxicants in publicly available chemical compilations, regulatory lists, and guidelines worldwide is reported here solely to support future research on neurotoxicity of environmental chemicals. We do not claim responsibility for any errors or omission in compiled evidence supporting the neurotoxicity of chemicals in our resource, and hence, users are advised to exercise their own informed decision in using the compiled list of potential neurotoxicants in our resource. Further, this work on the compilation of a resource on potential neurotoxicants and their toxicological endpoints is solely based on our scientific understanding of the topic, and this does not necessarily reflect the views or policies of our employers or funders.