Perfluorooctanesulfonic acid

Perfluorooctanesulfonic acid



Chemical nameGene identifierToxCast assay component endpoint name
Perfluorooctanesulfonic acidARACEA_AR_antagonist_80hr
Perfluorooctanesulfonic acidTP53APR_HepG2_p53Act_24h_up
Perfluorooctanesulfonic acidTP53APR_HepG2_p53Act_72h_up
Perfluorooctanesulfonic acidFOSATG_AP_1_CIS_up
Perfluorooctanesulfonic acidJUNATG_AP_1_CIS_up
Perfluorooctanesulfonic acidNR1H2ATG_DR4_LXR_CIS_dn
Perfluorooctanesulfonic acidNR1H3ATG_DR4_LXR_CIS_dn
Perfluorooctanesulfonic acidESR1ATG_ERa_TRANS_up
Perfluorooctanesulfonic acidESR1ATG_ERE_CIS_up
Perfluorooctanesulfonic acidMTF1ATG_MRE_CIS_up
Perfluorooctanesulfonic acidNFE2L2ATG_NRF2_ARE_CIS_up
Perfluorooctanesulfonic acidTP53ATG_p53_CIS_dn
Perfluorooctanesulfonic acidPAX6ATG_Pax6_CIS_up
Perfluorooctanesulfonic acidPPARAATG_PPARa_TRANS_up
Perfluorooctanesulfonic acidPPARGATG_PPARg_TRANS_up
Perfluorooctanesulfonic acidPPARAATG_PPRE_CIS_up
Perfluorooctanesulfonic acidPPARDATG_PPRE_CIS_up
Perfluorooctanesulfonic acidPPARGATG_PPRE_CIS_up
Perfluorooctanesulfonic acidNR1I2ATG_PXRE_CIS_up
Perfluorooctanesulfonic acidNR1I2ATG_PXR_TRANS_up
Perfluorooctanesulfonic acidSP1ATG_Sp1_CIS_up
Perfluorooctanesulfonic acidTGFB1ATG_TGFb_CIS_up
Perfluorooctanesulfonic acidHLA-DRABSK_BE3C_HLADR_down
Perfluorooctanesulfonic acidIL1ABSK_BE3C_IL1a_down
Perfluorooctanesulfonic acidCXCL10BSK_BE3C_IP10_down
Perfluorooctanesulfonic acidSERPINE1BSK_BE3C_PAI1_down
Perfluorooctanesulfonic acidTGFB1BSK_BE3C_TGFb1_down
Perfluorooctanesulfonic acidPLATBSK_BE3C_tPA_down
Perfluorooctanesulfonic acidPLAUBSK_BE3C_uPA_down
Perfluorooctanesulfonic acidCOL3A1BSK_hDFCGF_CollagenIII_down
Perfluorooctanesulfonic acidCXCL10BSK_hDFCGF_IP10_down
Perfluorooctanesulfonic acidVCAM1BSK_hDFCGF_VCAM1_down
Perfluorooctanesulfonic acidCXCL10BSK_KF3CT_IP10_down
Perfluorooctanesulfonic acidMMP9BSK_KF3CT_MMP9_down
Perfluorooctanesulfonic acidTGFB1BSK_KF3CT_TGFb1_down
Perfluorooctanesulfonic acidCXCL8BSK_LPS_IL8_up
Perfluorooctanesulfonic acidCD40BSK_SAg_CD40_down
Perfluorooctanesulfonic acidCYP2B6CLD_CYP2B6_24hr
Perfluorooctanesulfonic acidSLC5A5NIS_RAIU_inhibition
Perfluorooctanesulfonic acidCYP19A1NVS_ADME_hCYP19A1
Perfluorooctanesulfonic acidCYP2C18NVS_ADME_hCYP2C18
Perfluorooctanesulfonic acidCYP2C19NVS_ADME_hCYP2C19
Perfluorooctanesulfonic acidCYP2C8NVS_ADME_hCYP2C8
Perfluorooctanesulfonic acidCYP2C9NVS_ADME_hCYP2C9
Perfluorooctanesulfonic acidCYP4F12NVS_ADME_hCYP4F12
Perfluorooctanesulfonic acidACP1NVS_ENZ_hACP1
Perfluorooctanesulfonic acidAKT1NVS_ENZ_hAKT1
Perfluorooctanesulfonic acidAKT2NVS_ENZ_hAKT2
Perfluorooctanesulfonic acidPRKAA1NVS_ENZ_hAMPKa1
Perfluorooctanesulfonic acidAURKANVS_ENZ_hAurA
Perfluorooctanesulfonic acidBACE1NVS_ENZ_hBACE
Perfluorooctanesulfonic acidBTKNVS_ENZ_hBTK
Perfluorooctanesulfonic acidCASP5NVS_ENZ_hCASP5
Perfluorooctanesulfonic acidCDK6NVS_ENZ_hCDK6
Perfluorooctanesulfonic acidCSNK1A1NVS_ENZ_hCK1a
Perfluorooctanesulfonic acidCSNK1DNVS_ENZ_hCK1D
Perfluorooctanesulfonic acidCSF1RNVS_ENZ_hCSF1R_Activator
Perfluorooctanesulfonic acidCSF1RNVS_ENZ_hCSF1R
Perfluorooctanesulfonic acidDUSP3NVS_ENZ_hDUSP3
Perfluorooctanesulfonic acidDYRK1ANVS_ENZ_hDYRK1a
Perfluorooctanesulfonic acidEGFRNVS_ENZ_hEGFR
Perfluorooctanesulfonic acidEPHA2NVS_ENZ_hEphA2
Perfluorooctanesulfonic acidFGFR1NVS_ENZ_hFGFR1
Perfluorooctanesulfonic acidFGFR3NVS_ENZ_hFGFR3
Perfluorooctanesulfonic acidFYNNVS_ENZ_hFyn
Perfluorooctanesulfonic acidGSK3BNVS_ENZ_hGSK3b
Perfluorooctanesulfonic acidHDAC3NVS_ENZ_hHDAC3
Perfluorooctanesulfonic acidCHUKNVS_ENZ_hIKKa
Perfluorooctanesulfonic acidINSRNVS_ENZ_hInsR_Activator
Perfluorooctanesulfonic acidINSRNVS_ENZ_hInsR
Perfluorooctanesulfonic acidLCKNVS_ENZ_hLck
Perfluorooctanesulfonic acidLYNNVS_ENZ_hLynA_Activator
Perfluorooctanesulfonic acidMAPK1NVS_ENZ_hMAPK1
Perfluorooctanesulfonic acidMAPK3NVS_ENZ_hMAPK3
Perfluorooctanesulfonic acidMAPKAPK5NVS_ENZ_hMAPKAPK5
Perfluorooctanesulfonic acidMARK1NVS_ENZ_hMARK1
Perfluorooctanesulfonic acidMETNVS_ENZ_hMet
Perfluorooctanesulfonic acidMMP13NVS_ENZ_hMMP13
Perfluorooctanesulfonic acidMMP3NVS_ENZ_hMMP3
Perfluorooctanesulfonic acidMMP7NVS_ENZ_hMMP7
Perfluorooctanesulfonic acidMMP9NVS_ENZ_hMMP9
Perfluorooctanesulfonic acidRPS6KA5NVS_ENZ_hMsk1
Perfluorooctanesulfonic acidPAK4NVS_ENZ_hPAK4
Perfluorooctanesulfonic acidPDE4ANVS_ENZ_hPDE4A1
Perfluorooctanesulfonic acidPDE5ANVS_ENZ_hPDE5
Perfluorooctanesulfonic acidPIK3CANVS_ENZ_hPI3Ka
Perfluorooctanesulfonic acidPRKACANVS_ENZ_hPKA
Perfluorooctanesulfonic acidPPP1CANVS_ENZ_hPPP1CA
Perfluorooctanesulfonic acidPPP2CANVS_ENZ_hPPP2CA
Perfluorooctanesulfonic acidPTENNVS_ENZ_hPTEN
Perfluorooctanesulfonic acidPTPN11NVS_ENZ_hPTPN11
Perfluorooctanesulfonic acidPTPN12NVS_ENZ_hPTPN12
Perfluorooctanesulfonic acidPTPN13NVS_ENZ_hPTPN13
Perfluorooctanesulfonic acidPTPN1NVS_ENZ_hPTPN1
Perfluorooctanesulfonic acidPTPN2NVS_ENZ_hPTPN2
Perfluorooctanesulfonic acidPTPN6NVS_ENZ_hPTPN6
Perfluorooctanesulfonic acidPTPRBNVS_ENZ_hPTPRB
Perfluorooctanesulfonic acidPTPRCNVS_ENZ_hPTPRC
Perfluorooctanesulfonic acidPTPRFNVS_ENZ_hPTPRF
Perfluorooctanesulfonic acidPTPRMNVS_ENZ_hPTPRM
Perfluorooctanesulfonic acidRAF1NVS_ENZ_hRAF1
Perfluorooctanesulfonic acidROCK1NVS_ENZ_hROCK1
Perfluorooctanesulfonic acidSGK1NVS_ENZ_hSGK1
Perfluorooctanesulfonic acidSIRT2NVS_ENZ_hSIRT2
Perfluorooctanesulfonic acidSIRT3NVS_ENZ_hSIRT3_Activator
Perfluorooctanesulfonic acidTEKNVS_ENZ_hTie2
Perfluorooctanesulfonic acidNTRK1NVS_ENZ_hTrkA
Perfluorooctanesulfonic acidFLT1NVS_ENZ_hVEGFR1
Perfluorooctanesulfonic acidKDRNVS_ENZ_hVEGFR2
Perfluorooctanesulfonic acidFLT4NVS_ENZ_hVEGFR3
Perfluorooctanesulfonic acidZAP70NVS_ENZ_hZAP70
Perfluorooctanesulfonic acidHTR5ANVS_GPCR_h5HT5A
Perfluorooctanesulfonic acidHTR6NVS_GPCR_h5HT6
Perfluorooctanesulfonic acidHTR7NVS_GPCR_h5HT7
Perfluorooctanesulfonic acidADORA2ANVS_GPCR_hAdoRA2a
Perfluorooctanesulfonic acidADRA2CNVS_GPCR_hAdra2C
Perfluorooctanesulfonic acidADRB1NVS_GPCR_hAdrb1
Perfluorooctanesulfonic acidDRD4NVS_GPCR_hDRD4.4
Perfluorooctanesulfonic acidLTB4RNVS_GPCR_hLTB4_BLT1
Perfluorooctanesulfonic acidNPY2RNVS_GPCR_hNPY2
Perfluorooctanesulfonic acidOPRD1NVS_GPCR_hOpiate_D1
Perfluorooctanesulfonic acidP2RY1NVS_GPCR_hPY2
Perfluorooctanesulfonic acidTBXA2RNVS_GPCR_hTXA2
Perfluorooctanesulfonic acidARNVS_NR_hAR
Perfluorooctanesulfonic acidNR1I3NVS_NR_hCAR_Antagonist
Perfluorooctanesulfonic acidESR1NVS_NR_hER
Perfluorooctanesulfonic acidNR3C1NVS_NR_hGR
Perfluorooctanesulfonic acidPPARGNVS_NR_hPPARg
Perfluorooctanesulfonic acidPGRNVS_NR_hPR
Perfluorooctanesulfonic acidNR1I2NVS_NR_hPXR
Perfluorooctanesulfonic acidRARANVS_NR_hRAR_Antagonist
Perfluorooctanesulfonic acidTHRANVS_NR_hTRa_Antagonist
Perfluorooctanesulfonic acidESR1OT_ER_ERaERb_0480
Perfluorooctanesulfonic acidESR2OT_ER_ERaERb_0480
Perfluorooctanesulfonic acidNFE2L2TOX21_ARE_BLA_agonist_ratio
Perfluorooctanesulfonic acidESR1TOX21_ERa_BLA_Antagonist_ratio
Perfluorooctanesulfonic acidESR2TOX21_ERb_BLA_Antagonist_ratio
Perfluorooctanesulfonic acidTP53TOX21_p53_BLA_p4_ratio
Perfluorooctanesulfonic acidPGRTOX21_PR_BLA_Antagonist_ratio

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NeurotoxKb is a comprehensive knowledgebase of potential environmental neurotoxicants specific to mammals compiled from well-established resources based on the observed neurotoxic endpoints in published literature. The presence of any of the potential neurotoxicants in publicly available chemical compilations, regulatory lists, and guidelines worldwide is reported here solely to support future research on neurotoxicity of environmental chemicals. We do not claim responsibility for any errors or omission in compiled evidence supporting the neurotoxicity of chemicals in our resource, and hence, users are advised to exercise their own informed decision in using the compiled list of potential neurotoxicants in our resource. Further, this work on the compilation of a resource on potential neurotoxicants and their toxicological endpoints is solely based on our scientific understanding of the topic, and this does not necessarily reflect the views or policies of our employers or funders.