Perfluorooctanoic acid

Perfluorooctanoic acid



Chemical nameGene identifierToxCast assay component endpoint name
Perfluorooctanoic acidFOSATG_AP_1_CIS_up
Perfluorooctanoic acidJUNATG_AP_1_CIS_up
Perfluorooctanoic acidNR1H2ATG_DR4_LXR_CIS_dn
Perfluorooctanoic acidNR1H3ATG_DR4_LXR_CIS_dn
Perfluorooctanoic acidESR1ATG_ERa_TRANS_up
Perfluorooctanoic acidESR1ATG_ERE_CIS_up
Perfluorooctanoic acidNFE2L2ATG_NRF2_ARE_CIS_up
Perfluorooctanoic acidPPARAATG_PPARa_TRANS_up
Perfluorooctanoic acidPPARGATG_PPARg_TRANS_up
Perfluorooctanoic acidPPARAATG_PPRE_CIS_up
Perfluorooctanoic acidPPARDATG_PPRE_CIS_up
Perfluorooctanoic acidPPARGATG_PPRE_CIS_up
Perfluorooctanoic acidNR1I2ATG_PXRE_CIS_up
Perfluorooctanoic acidRORAATG_RORE_CIS_dn
Perfluorooctanoic acidRORBATG_RORE_CIS_dn
Perfluorooctanoic acidRORCATG_RORE_CIS_dn
Perfluorooctanoic acidSP1ATG_Sp1_CIS_up
Perfluorooctanoic acidTHRAATG_THRa1_TRANS_dn
Perfluorooctanoic acidPLAURBSK_3C_uPAR_down
Perfluorooctanoic acidMMP1BSK_BE3C_MMP1_up
Perfluorooctanoic acidICAM1BSK_KF3CT_ICAM1_down
Perfluorooctanoic acidSELEBSK_LPS_Eselectin_up
Perfluorooctanoic acidTNFBSK_LPS_TNFa_down
Perfluorooctanoic acidCYP2B6CLD_CYP2B6_24hr
Perfluorooctanoic acidGSTA2CLD_GSTA2_48hr
Perfluorooctanoic acidHMGCS2CLD_HMGCS2_48hr
Perfluorooctanoic acidACP1NVS_ENZ_hACP1
Perfluorooctanoic acidBACE1NVS_ENZ_hBACE
Perfluorooctanoic acidPIK3CANVS_ENZ_hPI3Ka
Perfluorooctanoic acidPPP1CANVS_ENZ_hPPP1CA
Perfluorooctanoic acidPPP2CANVS_ENZ_hPPP2CA
Perfluorooctanoic acidTEKNVS_ENZ_hTie2
Perfluorooctanoic acidADORA2ANVS_GPCR_hAdoRA2a
Perfluorooctanoic acidLTB4RNVS_GPCR_hLTB4_BLT1
Perfluorooctanoic acidNR1I3NVS_NR_hCAR_Antagonist
Perfluorooctanoic acidPPARGNVS_NR_hPPARg
Perfluorooctanoic acidNFE2L2TOX21_ARE_BLA_agonist_ratio
Perfluorooctanoic acidESR1TOX21_ERa_BLA_Antagonist_ratio
Perfluorooctanoic acidESR2TOX21_ERb_BLA_Antagonist_ratio
Perfluorooctanoic acidESRRATOX21_ERR_Antagonist
Perfluorooctanoic acidPPARDTOX21_PPARd_BLA_agonist_ratio
Perfluorooctanoic acidPPARDTOX21_PPARd_BLA_antagonist_ratio
Perfluorooctanoic acidPPARGTOX21_PPARg_BLA_antagonist_ratio
Perfluorooctanoic acidRXRATOX21_RXR_BLA_Agonist_ratio

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NeurotoxKb is a comprehensive knowledgebase of potential environmental neurotoxicants specific to mammals compiled from well-established resources based on the observed neurotoxic endpoints in published literature. The presence of any of the potential neurotoxicants in publicly available chemical compilations, regulatory lists, and guidelines worldwide is reported here solely to support future research on neurotoxicity of environmental chemicals. We do not claim responsibility for any errors or omission in compiled evidence supporting the neurotoxicity of chemicals in our resource, and hence, users are advised to exercise their own informed decision in using the compiled list of potential neurotoxicants in our resource. Further, this work on the compilation of a resource on potential neurotoxicants and their toxicological endpoints is solely based on our scientific understanding of the topic, and this does not necessarily reflect the views or policies of our employers or funders.