ReCAnt | Resource on Chemicals Used in Aquaculture and Their Ecotoxicity

Diflubenzuron

Effects reported: Genetics Development Mortality Behavior

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ⓘ Table glossary

Reference	Experiment type	Cell / tissue	Test organism	Lifestage	Administration	Administered dose	Significant dose	Trend	Measurement	Effect
PMID:23836768	In vivo	-	Gadus morhua	Juvenile	Administered a single dose of diflubenzuron dissolved in propylene glycol−saline (50%:50%) into the caudal vein using a syringe	3.0-10.0 mg/kg	3.0-10.0 mg/kg	Decreased	Carnitine palmitoyltransferase 1a, liver mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Administered a single dose of diflubenzuron dissolved in propylene glycol−saline (50%:50%) into the caudal vein using a syringe	10 mg/kg	10 mg/kg	Decreased	Cytochrome P450, family 4, subfamily F, Polypeptide 2 mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Administered a single dose of diflubenzuron dissolved in propylene glycol−saline (50%:50%) into the caudal vein using a syringe	3.0-50.0 mg/kg	3.0-50.0 mg/kg	Decreased	ELOVL fatty acid elongase 5 mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Administered a single dose of diflubenzuron dissolved in propylene glycol−saline (50%:50%) into the caudal vein using a syringe	3.0-10.0 mg/kg	3.0-10.0 mg/kg	Decreased	Mitogen-activated protein kinase 1 mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Administered a single dose of diflubenzuron dissolved in propylene glycol−saline (50%:50%) into the caudal vein using a syringe	3.0-10.0 mg/kg	3.0-10.0 mg/kg	Decreased	Prostaglandin G/H synthase 2 mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Administered a single dose of diflubenzuron dissolved in propylene glycol−saline (50%:50%) into the caudal vein using a syringe	10.0-50.0 mg/kg	10 mg/kg	Increased	Cytochrome P450, CYP3A mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Orally medicated with feed pellets containing diflubenzuron for 14 days	3 mg/kg/day	3 mg/kg/day	Decreased	Catalase mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Orally medicated with feed pellets containing diflubenzuron for 14 days	3 mg/kg/day	3 mg/kg/day	Decreased	Glutathione S-transferase mu mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Orally medicated with feed pellets containing diflubenzuron for 14 days	3 mg/kg/day	3 mg/kg/day	Decreased	Glutathione S-transferase pi mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Orally medicated with feed pellets containing diflubenzuron for 14 days	3 mg/kg/day	3 mg/kg/day	Decreased	Glutathione S-transferase theta-1 mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Orally medicated with feed pellets containing diflubenzuron for 14 days	3 mg/kg/day	3 mg/kg/day	Decreased	NGT2 mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Orally medicated with feed pellets containing diflubenzuron for 14 days	3 mg/kg/day	3 mg/kg/day	Decreased	UDP glucuronosyltransferase 1 family a, b mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Orally medicated with feed pellets containing diflubenzuron for 14 days	3 mg/kg/day	3 mg/kg/day	Decreased	p53 mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Orally medicated with feed pellets containing diflubenzuron for 14 days	3 mg/kg/day	3 mg/kg/day	Decreased	slc6a9a mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Orally medicated with feed pellets containing diflubenzuron for 14 days	3 mg/kg/day	3 mg/kg/day	Increased	Apoptosis regulator Bcl-2 mRNA	Genetics
	In vivo	-	Gadus morhua	Juvenile	Orally medicated with feed pellets containing diflubenzuron for 14 days	3 mg/kg/day	3 mg/kg/day	Increased	Carnitine palmitoyltransferase 1a, liver mRNA	Genetics
PMID:28876214	In vivo	-	Pandalus borealis	Adult	Medicated feed (1 g) was added directly to each tank 4 times	4 g/2 weeks	4 g/2 weeks	Decreased	Molting	Development
	In vivo	-	Pandalus borealis	Adult	Medicated feed (1 g) was added directly to each tank 4 times	4 g/2 weeks	4 g/2 weeks	Decreased	Survival	Mortality
	In vivo	-	Pandalus borealis	Adult	Medicated feed (1 g) was added directly to each tank 7 times	7 g/2 weeks	7 g/2 weeks	Decreased	Molting	Development
	In vivo	-	Pandalus borealis	Adult	Medicated feed (1 g) was added directly to each tank 7 times	7 g/2 weeks	7 g/2 weeks	Decreased	Survival	Mortality
PMID:29524742	In vivo	-	Pandalus borealis	Larva	Medicated fish feed pellet	0.6 g/kg	0.6 g/kg	Decreased	Maturity	Development
	In vivo	-	Pandalus borealis	Larva	Medicated fish feed pellet	0.6 g/kg	0.6 g/kg	Decreased	Survival	Mortality
	In vivo	-	Pandalus borealis	Larva	Medicated fish feed pellet	0.6 g/kg	0.6 g/kg	Decreased	Swimming	Behavior

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Glossary ×

ReferencePubMed ID of research paper

Experimental TypeIn vivo or in vitro

Cell / TissueIf in vitro, cells derived from aquaculture-relevant species

Cell / TissueIf in vitro, tissues obtained from aquaculture-relevant species

Cell / TissueIf in vivo, left blank

Test OrganismAquaculture-relevant species tested for toxic effect

LifestageLifestage of the test organism if mentioned in the reference

AdministrationRoute by which the chemical enters the test organism or treatment method

Administered dose rangeDifferent doses of chemicals tested in this study

Significant dose rangeSignificant result(s) at specific doses

Trend Direction of effect over time

Measurement Parameter used to quantify the effect

Effect Overall observed biological outcome or toxicological effect

Diflubenzuron

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