Associated High Confidence AOPs |
---|
AOP Identifier | AOP Title | AO Classification | OECD Status | Coverage Score | KE Identifier | KE Name |
---|---|---|---|---|---|---|
AOP:3 | Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits | Nervous System Disease | WPHA/WNT Endorsed | 0.29 | KE:177 | Mitochondrial dysfunction |
KE:188 | Neuroinflammation | |||||
AOP:4 | Ecdysone receptor agonism leading to incomplete ecdysis associated mortality | Unclassified | - | 0.3 | KE:1264 | Increase, Nuclear receptor E75b gene expression |
KE:993 | Decrease, Abdominal muscle contraction | |||||
KE:1265 | Increase, Fushi tarazu factor-1 gene expression | |||||
AOP:7 | Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female | Reproductive System Disease; Endocrine System Disease; Reproductive System Disease | Under Review | 0.4 | KE:3 | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells |
KE:219 | Reduction, Plasma 17beta-estradiol concentrations | |||||
AOP:8 | Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals | Nervous System Disease | Under Development | 0.22 | KE:758 | Hippocampal Physiology, Altered |
KE:756 | Hippocampal gene expression, Altered | |||||
AOP:10 | Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain | Nervous System Disease | WPHA/WNT Endorsed | 0.17 | KE:669 | Reduction, Neuronal synaptic inhibition |
AOP:15 | Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations | Genetic Disease | WPHA/WNT Endorsed | 0.25 | KE:155 | Inadequate DNA repair |
AOP:16 | Acetylcholinesterase inhibition leading to acute mortality | Unclassified | Under Development | 0.14 | KE:445 | Respiratory distress/arrest |
AOP:18 | PPARα activation in utero leading to impaired fertility in males | Reproductive System Disease | Under Review | 0.38 | KE:413 | Reduction, Testosterone synthesis in Leydig cells |
KE:1690 | Decrease, circulating testosterone levels | |||||
KE:289 | Decrease, Translocator protein (TSPO) | |||||
AOP:23 | Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) | Unclassified | WPHA/WNT Endorsed | 0.3 | KE:3 | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells |
KE:285 | Reduction, Vitellogenin synthesis in liver | |||||
KE:219 | Reduction, Plasma 17beta-estradiol concentrations | |||||
AOP:25 | Aromatase inhibition leading to reproductive dysfunction | Unclassified | WPHA/WNT Endorsed | 0.38 | KE:3 | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells |
KE:285 | Reduction, Vitellogenin synthesis in liver | |||||
KE:219 | Reduction, Plasma 17beta-estradiol concentrations | |||||
AOP:27 | Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) | Gastrointestinal System Disease | Under Development | 0.38 | KE:149 | Increase, Inflammation |
KE:1115 | Increase, Reactive oxygen species | |||||
KE:288 | Activation of specific nuclear receptors, Transcriptional change | |||||
AOP:30 | Estrogen receptor antagonism leading to reproductive dysfunction | Unclassified | Under Review | 0.17 | KE:285 | Reduction, Vitellogenin synthesis in liver |
AOP:36 | Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis | Gastrointestinal System Disease; Inherited Metabolic Disorder | - | 0.12 | KE:140 | Decreased, HSD17B10 expression |
AOP:37 | PPARα activation leading to hepatocellular adenomas and carcinomas in rodents | Cancer; Gastrointestinal System Disease | Under Development | 0.2 | KE:716 | Increase, cell proliferation (hepatocytes) |
AOP:38 | Protein Alkylation leading to Liver Fibrosis | Gastrointestinal System Disease | WPHA/WNT Endorsed | 0.29 | KE:1493 | Increased Pro-inflammatory mediators |
KE:55 | Increase, Cell injury/death | |||||
AOP:41 | Sustained AhR Activation leading to Rodent Liver Tumours | Cancer; Gastrointestinal System Disease | Under Review | 0.6 | KE:854 | Alterations, Cellular proliferation / hyperplasia |
KE:853 | Changes/Inhibition, Cellular Homeostasis and Apoptosis | |||||
KE:139 | N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects | |||||
AOP:58 | NR1I3 (CAR) suppression leading to hepatic steatosis | Gastrointestinal System Disease; Inherited Metabolic Disorder | - | 0.25 | KE:462 | Up Regulation, SCD-1 |
KE:454 | Increased, Triglyceride formation | |||||
KE:463 | Up Regulation, FAS | |||||
KE:54 | Up Regulation, CD36 | |||||
AOP:60 | NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis | Gastrointestinal System Disease; Inherited Metabolic Disorder | - | 0.42 | KE:454 | Increased, Triglyceride formation |
KE:54 | Up Regulation, CD36 | |||||
KE:462 | Up Regulation, SCD-1 | |||||
KE:474 | Down Regulation, HMGCS2 | |||||
KE:472 | Down Regulation, CPT1A | |||||
AOP:64 | Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility | Reproductive System Disease | - | 0.57 | KE:413 | Reduction, Testosterone synthesis in Leydig cells |
KE:1690 | Decrease, circulating testosterone levels | |||||
KE:496 | Increased apoptosis, decreased fetal/adult Leydig Cells | |||||
KE:520 | Decreased sperm quantity or quality in the adult, Decreased fertility | |||||
AOP:73 | Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity | Unclassified | - | 0.15 | KE:10059 | Decreased LH surge for 24 hours |
KE:531 | Decreased, LH Surge | |||||
AOP:77 | Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 | Unclassified | - | 0.29 | KE:177 | Mitochondrial dysfunction |
KE:341 | Impairment, Learning and memory | |||||
AOP:78 | Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 | Unclassified | - | 0.25 | KE:177 | Mitochondrial dysfunction |
KE:341 | Impairment, Learning and memory | |||||
AOP:79 | Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure | Unclassified | - | 0.2 | KE:177 | Mitochondrial dysfunction |
AOP:80 | Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure | Unclassified | - | 0.25 | KE:177 | Mitochondrial dysfunction |
KE:664 | Overwhelmed, Mitochondrial DNA repair mechanisms | |||||
AOP:87 | Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure | Unclassified | - | 0.25 | KE:177 | Mitochondrial dysfunction |
KE:341 | Impairment, Learning and memory | |||||
AOP:88 | Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste | Unclassified | - | 0.14 | KE:341 | Impairment, Learning and memory |
AOP:89 | Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure | Unclassified | - | 0.12 | KE:341 | Impairment, Learning and memory |
AOP:90 | Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 | Unclassified | - | 0.12 | KE:341 | Impairment, Learning and memory |
AOP:94 | Sodium channel inhibition leading to congenital malformations | Unclassified | - | 0.17 | KE:445 | Respiratory distress/arrest |
AOP:96 | Axonal sodium channel modulation leading to acute mortality | Unclassified | - | 0.33 | KE:602 | Increased, Ataxia, paralysis, or hyperactivity |
KE:600 | Overactivation, Neuronotransmitter release | |||||
AOP:102 | Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition | Reproductive System Disease | - | 0.2 | KE:690 | Reduced, Luteinizing hormone (LH), plasma |
KE:693 | Increased, cyclic adenosine monophosphate | |||||
AOP:103 | Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint | Reproductive System Disease | - | 0.1 | KE:690 | Reduced, Luteinizing hormone (LH), plasma |
AOP:104 | Altered ion channel activity leading impaired heart function | Unclassified | - | 0.25 | KE:698 | Altered, Action Potential |
AOP:107 | Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat | Cancer; Gastrointestinal System Disease | Under Review | 0.4 | KE:1214 | Altered gene expression specific to CAR activation, Hepatocytes |
KE:716 | Increase, cell proliferation (hepatocytes) | |||||
AOP:108 | Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) | Cancer; Gastrointestinal System Disease | - | 0.17 | KE:768 | Increase, Cytotoxicity |
AOP:109 | Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) | Cancer; Respiratory System Disease | - | 0.2 | KE:734 | Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) |
AOP:110 | Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) | Cancer; Endocrine System Disease | - | 0.29 | KE:277 | Thyroid hormone synthesis, Decreased |
KE:739 | Increase, Hypertrophy and proliferation (follicular cell) | |||||
AOP:111 | Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) | Cancer; Reproductive System Disease | - | 0.2 | KE:754 | Increased, Luteinizing hormone (LH) |
AOP:113 | Glutamate-gated chloride channel activation leading to acute mortality | Unclassified | - | 0.17 | KE:764 | N/A, Ataxia, paralysis, or hyperactivity |
AOP:114 | HPPD inhibition leading to corneal papillomas and carcinomas (in rat) | Cancer | - | 0.33 | KE:777 | Increase, Inflammation (corneal cells) |
KE:778 | Increase, Regenerative cell proliferation (corneal cells) | |||||
AOP:115 | Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) | Cancer | - | 0.4 | KE:149 | Increase, Inflammation |
KE:781 | Increase, Regenerative cell proliferation (forestomach epithelial cells) | |||||
AOP:117 | Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) | Cancer; Gastrointestinal System Disease | Under Development | 0.25 | KE:716 | Increase, cell proliferation (hepatocytes) |
AOP:119 | Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) | Cancer; Endocrine System Disease | - | 0.29 | KE:277 | Thyroid hormone synthesis, Decreased |
KE:739 | Increase, Hypertrophy and proliferation (follicular cell) | |||||
AOP:120 | Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) | Cancer; Reproductive System Disease | - | 0.4 | KE:1690 | Decrease, circulating testosterone levels |
KE:791 | Increased, Leutinizing hormone (LH) | |||||
AOP:122 | Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation | Unclassified | - | 0.4 | KE:3 | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells |
KE:799 | Increased, HIF-1 heterodimer | |||||
KE:285 | Reduction, Vitellogenin synthesis in liver | |||||
KE:219 | Reduction, Plasma 17beta-estradiol concentrations | |||||
AOP:123 | Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription | Unclassified | - | 0.45 | KE:3 | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells |
KE:802 | Increased, HIF-1 alpha transcription | |||||
KE:219 | Reduction, Plasma 17beta-estradiol concentrations | |||||
KE:285 | Reduction, Vitellogenin synthesis in liver | |||||
KE:799 | Increased, HIF-1 heterodimer | |||||
AOP:126 | Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation | Unclassified | - | 0.15 | KE:10059 | Decreased LH surge for 24 hours |
KE:531 | Decreased, LH Surge | |||||
AOP:130 | Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity | Gastrointestinal System Disease | Under Development | 0.09 | KE:177 | Mitochondrial dysfunction |
AOP:136 | Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors | Benign Neoplasm; Respiratory System Disease | Under Review | 0.29 | KE:768 | Increase, Cytotoxicity |
KE:870 | Increase, Cell Proliferation | |||||
AOP:144 | Endocytic lysosomal uptake leading to liver fibrosis | Gastrointestinal System Disease | Under Review | 0.33 | KE:177 | Mitochondrial dysfunction |
KE:1493 | Increased Pro-inflammatory mediators | |||||
KE:55 | Increase, Cell injury/death | |||||
AOP:148 | EGFR Activation Leading to Decreased Lung Function | Respiratory System Disease | Under Development | 0.25 | KE:962 | Increase, Mucin production |
AOP:159 | Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation | Unclassified | WPHA/WNT Endorsed | 0.12 | KE:277 | Thyroid hormone synthesis, Decreased |
AOP:160 | Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality | Unclassified | - | 0.14 | KE:1015 | Increased, Neuronal synaptic inhibition |
AOP:161 | Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality | Unclassified | - | 0.14 | KE:1015 | Increased, Neuronal synaptic inhibition |
AOP:164 | Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse | Cancer; Reproductive System Disease | - | 0.17 | KE:1042 | Proliferation/Clonal Expansion, smooth muscle |
AOP:167 | Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. | Reproductive System Disease; Cancer | - | 0.29 | KE:1066 | Promotion, SIX-1 postive basal-type progenitor cells |
KE:1067 | Proliferation/Clonal Expansion, aberrant basal cells | |||||
AOP:173 | Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis | Musculoskeletal System Disease; Respiratory System Disease | WPHA/WNT Endorsed | 0.25 | KE:1497 | Increased, recruitment of inflammatory cells |
KE:1496 | Increased, secretion of proinflammatory mediators | |||||
AOP:175 | Thyroperoxidase inhibition leading to altered amphibian metamorphosis | Unclassified | - | 0.25 | KE:277 | Thyroid hormone synthesis, Decreased |
AOP:176 | Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis | Unclassified | - | 0.2 | KE:277 | Thyroid hormone synthesis, Decreased |
AOP:188 | Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis | Unclassified | - | 0.2 | KE:277 | Thyroid hormone synthesis, Decreased |
AOP:190 | Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis | Unclassified | - | 0.17 | KE:1829 | Altered, Thyroid hormone-dependent gene expression |
AOP:191 | Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis | Unclassified | - | 0.25 | KE:1829 | Altered, Thyroid hormone-dependent gene expression |
AOP:192 | Pendrin inhibition leading to altered amphibian metamorphosis | Unclassified | - | 0.25 | KE:277 | Thyroid hormone synthesis, Decreased |
AOP:193 | Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis | Unclassified | - | 0.25 | KE:277 | Thyroid hormone synthesis, Decreased |
AOP:201 | Juvenile hormone receptor agonism leading to male offspring induction associated population decline | Unclassified | - | 0.17 | KE:1206 | Induction, Doublesex1 gene |
AOP:206 | Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis | Musculoskeletal System Disease; Respiratory System Disease | Under Development | 0.17 | KE:149 | Increase, Inflammation |
AOP:207 | NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans | Reproductive System Disease | - | 0.5 | KE:1115 | Increase, Reactive oxygen species |
KE:177 | Mitochondrial dysfunction | |||||
KE:1262 | Apoptosis | |||||
KE:1281 | Increased, DNA Damage-Repair | |||||
AOP:213 | Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) | Gastrointestinal System Disease; Inherited Metabolic Disorder | - | 0.17 | KE:1115 | Increase, Reactive oxygen species |
AOP:218 | Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity | Unclassified | - | 0.17 | KE:1141 | Decreased, Reproductive Success |
AOP:219 | Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior | Unclassified | - | 0.33 | KE:1141 | Decreased, Reproductive Success |
KE:1390 | Sexual behavior, decreased | |||||
AOP:271 | Inhibition of thyroid peroxidase leading to impaired fertility in fish | Unclassified | Under Development | 0.4 | KE:277 | Thyroid hormone synthesis, Decreased |
KE:219 | Reduction, Plasma 17beta-estradiol concentrations | |||||
AOP:275 | Histone deacetylase inhibition leads to neural tube defects | Neural Tube Defect | - | 0.2 | KE:1239 | Altered, Gene Expression |
AOP:276 | Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome | Urinary System Disease | - | 0.17 | KE:1562 | Decreased Na/K ATPase activity |
AOP:278 | IKK complex inhibition leading to liver injury | Unclassified | - | 0.12 | KE:55 | Increase, Cell injury/death |
AOP:280 | α-diketone-induced bronchiolitis obliterans | Musculoskeletal System Disease; Respiratory System Disease | - | 0.14 | KE:149 | Increase, Inflammation |
AOP:288 | Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) | Endocrine System Disease | - | 0.12 | KE:1690 | Decrease, circulating testosterone levels |
AOP:289 | Inhibition of 5α-reductase leading to impaired fecundity in female fish | Unclassified | Under Development | 0.17 | KE:219 | Reduction, Plasma 17beta-estradiol concentrations |
AOP:293 | Increased DNA damage leading to increased risk of breast cancer | Genetic Disease; Thoracic Disease; Cancer | Under Development | 0.22 | KE:1493 | Increased Pro-inflammatory mediators |
KE:1182 | Increase, Cell Proliferation (Epithelial Cells) | |||||
AOP:294 | Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer | Genetic Disease; Thoracic Disease; Cancer | Under Development | 0.22 | KE:1493 | Increased Pro-inflammatory mediators |
KE:1182 | Increase, Cell Proliferation (Epithelial Cells) | |||||
AOP:297 | Inhibition of retinaldehyde dehydrogenase leads to population decline | Unclassified | Under Development | 0.17 | KE:1643 | Altered, Visual function |
AOP:299 | Deposition of energy leading to population decline via DNA oxidation and follicular atresia | Unclassified | - | 0.14 | KE:1115 | Increase, Reactive oxygen species |
AOP:305 | 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring | Unclassified | Under Development | 0.2 | KE:286 | Altered, Transcription of genes by the androgen receptor |
AOP:306 | Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring | Unclassified | Under Development | 0.25 | KE:286 | Altered, Transcription of genes by the androgen receptor |
AOP:310 | Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR | Unclassified | - | 0.25 | KE:3 | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells |
KE:285 | Reduction, Vitellogenin synthesis in liver | |||||
KE:219 | Reduction, Plasma 17beta-estradiol concentrations | |||||
AOP:311 | Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis | Unclassified | - | 0.14 | KE:1115 | Increase, Reactive oxygen species |
AOP:320 | Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality | Unclassified | Under Development | 0.22 | KE:1750 | Increased inflammatory immune responses |
KE:1496 | Increased, secretion of proinflammatory mediators | |||||
AOP:321 | Reduced environmental pH leading to thinner shells in Mytilus edulis | Unclassified | - | 0.18 | KE:592 | Reduced, survival |
KE:10042 | Abnormal development | |||||
AOP:334 | Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration | Unclassified | - | 0.33 | KE:2089 | Altered Bone Cell Homeostasis |
KE:2245 | Altered Cell Differentiation Signaling | |||||
AOP:344 | Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring | Unclassified | Under Development | 0.25 | KE:286 | Altered, Transcription of genes by the androgen receptor |
AOP:345 | Androgen receptor (AR) antagonism leading to decreased fertility in females | Endocrine System Disease; Reproductive System Disease; Reproductive System Disease | Under Development | 0.17 | KE:286 | Altered, Transcription of genes by the androgen receptor |
AOP:346 | Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation | Unclassified | WPHA/WNT Endorsed | 0.4 | KE:1789 | Reduction, 17beta-estradiol synthesis by the undifferentiated gonad |
KE:1790 | Increased, Differentiation to Testis | |||||
AOP:362 | Immune mediated hepatitis | Gastrointestinal System Disease; Immune System Disease | - | 0.12 | KE:177 | Mitochondrial dysfunction |
AOP:363 | Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure | Unclassified | Under Review | 0.25 | KE:277 | Thyroid hormone synthesis, Decreased |
KE:1643 | Altered, Visual function | |||||
AOP:364 | Thyroperoxidase inhibition leading to altered visual function via decreased eye size | Unclassified | Under Development | 0.25 | KE:277 | Thyroid hormone synthesis, Decreased |
KE:1643 | Altered, Visual function | |||||
AOP:365 | Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning | Unclassified | Under Development | 0.25 | KE:277 | Thyroid hormone synthesis, Decreased |
KE:1643 | Altered, Visual function | |||||
AOP:372 | Androgen receptor antagonism leading to testicular cancer | Endocrine System Disease; Reproductive System Disease; Cancer | - | 0.2 | KE:286 | Altered, Transcription of genes by the androgen receptor |
AOP:374 | Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis | Nervous System Disease | Under Development | 0.5 | KE:188 | Neuroinflammation |
KE:352 | N/A, Neurodegeneration | |||||
AOP:376 | Androgen receptor agonism leading to male-biased sex ratio | Unclassified | WPHA/WNT Endorsed | 0.25 | KE:1790 | Increased, Differentiation to Testis |
AOP:379 | Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation | Cardiovascular System Disease | Under Development | 0.14 | KE:1869 | Diminished protective oxidative stress response |
AOP:382 | Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis | Musculoskeletal System Disease; Respiratory System Disease | Under Development | 0.33 | KE:1115 | Increase, Reactive oxygen species |
KE:1496 | Increased, secretion of proinflammatory mediators | |||||
AOP:383 | Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis | Gastrointestinal System Disease | Under Development | 0.17 | KE:1115 | Increase, Reactive oxygen species |
AOP:386 | Deposition of ionizing energy leading to population decline via inhibition of photosynthesis | Reproductive System Disease | - | 0.12 | KE:1115 | Increase, Reactive oxygen species |
AOP:387 | Deposition of ionising energy leading to population decline via mitochondrial dysfunction | Reproductive System Disease | - | 0.25 | KE:40 | Decrease, Mitochondrial ATP production |
KE:1115 | Increase, Reactive oxygen species | |||||
AOP:397 | Bulky DNA adducts leading to mutations | Genetic Disease | Under Development | 0.33 | KE:155 | Inadequate DNA repair |
AOP:399 | Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) | Unclassified | - | 0.25 | KE:1821 | Decrease, Cell proliferation |
KE:1643 | Altered, Visual function | |||||
AOP:409 | Frustrated phagocytosis leads to malignant mesothelioma | Cancer | - | 0.62 | KE:870 | Increase, Cell Proliferation |
KE:1496 | Increased, secretion of proinflammatory mediators | |||||
KE:1115 | Increase, Reactive oxygen species | |||||
KE:1896 | Genomic instability | |||||
KE:1497 | Increased, recruitment of inflammatory cells | |||||
AOP:410 | GSK3beta inactivation leading to increased mortality via defects in developing inner ear | Unclassified | - | 0.1 | KE:1008 | Reduced, Hearing |
AOP:413 | Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure | Unclassified | - | 0.33 | KE:1115 | Increase, Reactive oxygen species |
KE:759 | Increased, Kidney Failure | |||||
AOP:418 | Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway | Respiratory System Disease | - | 0.2 | KE:1115 | Increase, Reactive oxygen species |
AOP:419 | Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway | Respiratory System Disease | - | 0.25 | KE:1262 | Apoptosis |
AOP:432 | Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia | Hematopoietic System Disease; Cancer | - | 0.36 | KE:155 | Inadequate DNA repair |
KE:870 | Increase, Cell Proliferation | |||||
KE:1493 | Increased Pro-inflammatory mediators | |||||
KE:403 | Suppression, Immune system | |||||
AOP:439 | Activation of the AhR leading to metastatic breast cancer | Thoracic Disease; Cancer | Under Development | 0.33 | KE:149 | Increase, Inflammation |
KE:1971 | Increased, tumor growth | |||||
KE:1262 | Apoptosis | |||||
AOP:441 | Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation | Congenital Nervous System Abnormality; Nervous System Disease | - | 0.14 | KE:1262 | Apoptosis |
AOP:443 | DNA damage and mutations leading to Metastatic Breast Cancer | Thoracic Disease; Cancer | Under Development | 0.2 | KE:1554 | Increase Chromosomal Aberrations |
KE:155 | Inadequate DNA repair | |||||
AOP:452 | Adverse outcome pathway of PM-induced respiratory toxicity | Respiratory System Disease | - | 0.09 | KE:1262 | Apoptosis |
AOP:460 | Antagonism of Smoothened receptor leading to orofacial clefting | Unclassified | Under Development | 0.33 | KE:1821 | Decrease, Cell proliferation |
KE:1262 | Apoptosis | |||||
KE:2040 | Decrease, GLI1/2 target gene expression | |||||
AOP:464 | Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits | Nervous System Disease | - | 0.11 | KE:177 | Mitochondrial dysfunction |
KE:389 | Increased, Intracellular Calcium overload | |||||
AOP:465 | Alcohol dehydrogenase leading to reproductive dysfunction | Unclassified | - | 0.12 | KE:2050 | Increase, developmental abnormalities |
AOP:467 | Knickkopf leading to mortality | Unclassified | - | 0.11 | KE:2050 | Increase, developmental abnormalities |
AOP:470 | Deposition of energy leads to abnormal vascular remodeling | Cardiovascular System Disease | Under Review | 0.12 | KE:1493 | Increased Pro-inflammatory mediators |
AOP:478 | Deposition of energy leading to occurrence of cataracts | Nervous System Disease; Monogenic Disease | Under Review | 0.3 | KE:870 | Increase, Cell Proliferation |
KE:155 | Inadequate DNA repair | |||||
KE:1636 | Increase, Chromosomal aberrations | |||||
AOP:479 | Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress | Cardiovascular System Disease; Thoracic Disease | Under Development | 0.43 | KE:177 | Mitochondrial dysfunction |
KE:55 | Increase, Cell injury/death | |||||
KE:1532 | Decrease, Cardiac contractility | |||||
AOP:480 | Mitochondrial complexes inhibition leading to heart failure via decreased ATP production | Cardiovascular System Disease; Thoracic Disease | Under Development | 0.6 | KE:40 | Decrease, Mitochondrial ATP production |
KE:177 | Mitochondrial dysfunction | |||||
KE:1532 | Decrease, Cardiac contractility | |||||
AOP:482 | Deposition of energy leading to occurrence of bone loss | Musculoskeletal System Disease | Under Review | 0.29 | KE:2089 | Altered Bone Cell Homeostasis |
KE:2245 | Altered Cell Differentiation Signaling | |||||
AOP:492 | Glutathione conjugation leading to reproductive dysfunction via oxidative stress | Reproductive System Disease | - | 0.2 | KE:1115 | Increase, Reactive oxygen species |
AOP:494 | AhR activation leading to liver fibrosis | Gastrointestinal System Disease | - | 0.17 | KE:55 | Increase, Cell injury/death |
AOP:495 | Androgen receptor activation leading to prostate cancer | Reproductive System Disease; Cancer | - | 0.33 | KE:854 | Alterations, Cellular proliferation / hyperplasia |
KE:1183 | Decreased, Apoptosis (Epithelial Cells) | |||||
KE:286 | Altered, Transcription of genes by the androgen receptor | |||||
AOP:496 | Androgen receptor agonism leading to reproduction dysfunction (in zebrafish) | Unclassified | - | 0.3 | KE:1690 | Decrease, circulating testosterone levels |
KE:286 | Altered, Transcription of genes by the androgen receptor | |||||
KE:219 | Reduction, Plasma 17beta-estradiol concentrations | |||||
AOP:503 | Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation | Reproductive System Disease; Cancer | Under Review | 0.17 | KE:1896 | Genomic instability |
AOP:517 | Pregnane X Receptor (PXR) activation leads to liver steatosis | Gastrointestinal System Disease; Inherited Metabolic Disorder | - | 0.2 | KE:54 | Up Regulation, CD36 |
AOP:519 | Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality | Cardiovascular System Disease | - | 0.5 | KE:1961 | Prolongation of Action Potential Duration |
KE:2283 | Increased the early premature depolarizations during repolarization | |||||
AOP:529 | Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis | Gastrointestinal System Disease; Inherited Metabolic Disorder | - | 0.12 | KE:2224 | Dysregulation of transcriptional expression within PPAR signaling network |
AOP:530 | Endocytotic lysosomal uptake leads to intestinal barrier disruption | Gastrointestinal System Disease | - | 0.4 | KE:177 | Mitochondrial dysfunction |
KE:55 | Increase, Cell injury/death | |||||
AOP:536 | Estrogen receptor agonism leading to reduced survival and population growth due to renal failure | Unclassified | - | 0.17 | KE:307 | Increase, Vitellogenin synthesis in liver |
AOP:537 | Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver | Unclassified | - | 0.2 | KE:307 | Increase, Vitellogenin synthesis in liver |
AOP:544 | Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation | Nervous System Disease | - | 0.17 | KE:149 | Increase, Inflammation |
AOP:549 | Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish | Unclassified | - | 0.12 | KE:219 | Reduction, Plasma 17beta-estradiol concentrations |
AOP:563 | Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis | Reproductive System Disease; Endocrine System Disease | - | 0.17 | KE:1262 | Apoptosis |
AOP:564 | DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. | Unclassified | - | 0.18 | KE:40 | Decrease, Mitochondrial ATP production |
KE:2151 | Disruption, neurotransmitter release |
AOP Identifier | AOP Title | AO Classification | OECD Status | Coverage Score | KE Identifier | KE Name |
---|---|---|---|---|---|---|
AOP:6 | Antagonist binding to PPARα leading to body-weight loss | Symptom | WPHA/WNT Endorsed | 0.12 | KE:864 | Decreased, Body Weight |
AOP:17 | Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory | Developmental Disorder Of Mental Health | WPHA/WNT Endorsed | 0.4 | KE:55 | Increase, Cell injury/death |
KE:1493 | Increased Pro-inflammatory mediators | |||||
KE:188 | Neuroinflammation | |||||
KE:341 | Impairment, Learning and memory | |||||
AOP:19 | Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) | Reproductive System Disease | - | 0.4 | KE:286 | Altered, Transcription of genes by the androgen receptor |
KE:337 | N/A, Impairment of reproductive capacity | |||||
AOP:21 | Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 | Unclassified | WPHA/WNT Endorsed | 0.6 | KE:317 | Altered, Cardiovascular development/function |
KE:1269 | Increase, COX-2 expression | |||||
KE:947 | Increase, Early Life Stage Mortality | |||||
AOP:34 | LXR activation leading to hepatic steatosis | Gastrointestinal System Disease; Inherited Metabolic Disorder | - | 0.31 | KE:177 | Mitochondrial dysfunction |
KE:54 | Up Regulation, CD36 | |||||
KE:258 | Activation, SCD-1 | |||||
KE:345 | N/A, Liver Steatosis | |||||
AOP:42 | Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals | Cognitive Disorder | WPHA/WNT Endorsed | 0.5 | KE:277 | Thyroid hormone synthesis, Decreased |
KE:758 | Hippocampal Physiology, Altered | |||||
KE:402 | Cognitive function, decreased | |||||
KE:756 | Hippocampal gene expression, Altered | |||||
AOP:43 | Disruption of VEGFR Signaling Leading to Developmental Defects | Unclassified | WPHA/WNT Endorsed | 0.2 | KE:1001 | Increased, Developmental Defects |
AOP:48 | Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. | Developmental Disorder Of Mental Health | WPHA/WNT Endorsed | 0.67 | KE:389 | Increased, Intracellular Calcium overload |
KE:177 | Mitochondrial dysfunction | |||||
KE:188 | Neuroinflammation | |||||
KE:55 | Increase, Cell injury/death | |||||
KE:352 | N/A, Neurodegeneration | |||||
KE:341 | Impairment, Learning and memory | |||||
AOP:54 | Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment | Developmental Disorder Of Mental Health | WPHA/WNT Endorsed | 0.3 | KE:277 | Thyroid hormone synthesis, Decreased |
KE:341 | Impairment, Learning and memory | |||||
KE:381 | Reduced levels of BDNF | |||||
AOP:91 | Sodium channel inhibition leading to reduced survival | Unclassified | - | 0.17 | KE:592 | Reduced, survival |
AOP:99 | Histamine (H2) receptor antagonism leading to reduced survival | Unclassified | - | 0.29 | KE:636 | Decreased, survival |
KE:341 | Impairment, Learning and memory | |||||
AOP:105 | Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) | Cancer; Urinary System Disease | - | 0.33 | KE:713 | Increase, Adenomas/carcinomas (renal tubular) |
KE:710 | Increase, Regenerative cell proliferation (tubular epithelial cells) | |||||
AOP:116 | Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) | Cancer; Urinary System Disease | - | 0.5 | KE:713 | Increase, Adenomas/carcinomas (renal tubular) |
KE:710 | Increase, Regenerative cell proliferation (tubular epithelial cells) | |||||
AOP:124 | HMG-CoA reductase inhibition leading to decreased fertility | Reproductive System Disease | - | 0.5 | KE:330 | Decrease, Fertility |
KE:1690 | Decrease, circulating testosterone levels | |||||
KE:807 | Decreased, cholesterol | |||||
AOP:131 | Aryl hydrocarbon receptor activation leading to uroporphyria | Inherited Metabolic Disorder | WPHA/WNT Endorsed | 0.33 | KE:369 | Uroporphyria |
KE:850 | Induction, CYP1A2/CYP1A5 | |||||
AOP:134 | Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals | Cognitive Disorder | - | 0.44 | KE:277 | Thyroid hormone synthesis, Decreased |
KE:758 | Hippocampal Physiology, Altered | |||||
KE:402 | Cognitive function, decreased | |||||
KE:756 | Hippocampal gene expression, Altered | |||||
AOP:139 | Alkylation of DNA leading to cancer 1 | Cancer | - | 0.5 | KE:885 | Increase, Cancer |
KE:155 | Inadequate DNA repair | |||||
AOP:149 | Peptide Oxidation Leading to Hypertension | Cardiovascular System Disease | Under Development | 0.1 | KE:952 | Hypertension |
AOP:150 | Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF | Unclassified | WPHA/WNT Endorsed | 0.43 | KE:317 | Altered, Cardiovascular development/function |
KE:947 | Increase, Early Life Stage Mortality | |||||
KE:948 | reduced production, VEGF | |||||
AOP:151 | AhR activation leading to preeclampsia | Cardiovascular System Disease | Under Development | 0.29 | KE:1893 | increase, Preeclampsia |
KE:948 | reduced production, VEGF | |||||
AOP:196 | Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation | Respiratory System Disease | - | 0.11 | KE:1226 | Increased Respiratory irritability and Chronic Cough, |
AOP:203 | 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline | Reproductive System Disease | - | 0.12 | KE:1141 | Decreased, Reproductive Success |
AOP:212 | Histone deacetylase inhibition leading to testicular atrophy | Reproductive System Disease | WPHA/WNT Endorsed | 0.33 | KE:1506 | Testicular atrophy |
KE:1262 | Apoptosis | |||||
AOP:220 | Cyp2E1 Activation Leading to Liver Cancer | Cancer; Gastrointestinal System Disease | WPHA/WNT Endorsed | 0.6 | KE:1393 | Hepatocytotoxicity |
KE:1394 | Induction, persistent proliferation/sustained proliferation | |||||
KE:1395 | Liver Cancer | |||||
AOP:237 | Substance interaction with lung resident cell membrane components leading to atherosclerosis | Cardiovascular System Disease | Under Development | 0.4 | KE:1443 | Atherosclerosis |
KE:1496 | Increased, secretion of proinflammatory mediators | |||||
AOP:242 | Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity | Unclassified | - | 0.12 | KE:636 | Decreased, survival |
AOP:245 | Reduction in photophosphorylation leading to growth inhibition in aquatic plants | Unclassified | - | 0.18 | KE:40 | Decrease, Mitochondrial ATP production |
KE:1521 | Decrease, Growth | |||||
AOP:256 | Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity | Urinary System Disease | Under Development | 0.4 | KE:177 | Mitochondrial dysfunction |
KE:814 | Occurrence, Kidney toxicity | |||||
AOP:257 | Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity | Urinary System Disease | Under Development | 0.2 | KE:814 | Occurrence, Kidney toxicity |
AOP:258 | Renal protein alkylation leading to kidney toxicity | Urinary System Disease | Under Development | 0.6 | KE:40 | Decrease, Mitochondrial ATP production |
KE:177 | Mitochondrial dysfunction | |||||
KE:814 | Occurrence, Kidney toxicity | |||||
AOP:260 | CYP2E1 activation and formation of protein adducts leading to neurodegeneration | Nervous System Disease | - | 0.14 | KE:1514 | Neurodegeneration |
AOP:269 | Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development | Unclassified | - | 0.17 | KE:10013 | Impaired growth and development |
AOP:270 | Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity | Unclassified | - | 0.12 | KE:10016 | Impaired locomotor activity |
AOP:272 | Deposition of energy leading to lung cancer | Cancer | WPHA/WNT Endorsed | 0.57 | KE:870 | Increase, Cell Proliferation |
KE:1556 | Increase, lung cancer | |||||
KE:155 | Inadequate DNA repair | |||||
KE:1636 | Increase, Chromosomal aberrations | |||||
AOP:274 | Histone deacetylase inhibition leads to impeded craniofacial development | Musculoskeletal System Disease | - | 0.25 | KE:1559 | Facial cartilage structures are reduced in size and morphologically distorted |
AOP:279 | Microtubule interacting drugs lead to peripheral neuropathy | Nervous System Disease | - | 0.25 | KE:1583 | Sensory axonal peripheral neuropathy |
AOP:281 | Acetylcholinesterase Inhibition Leading to Neurodegeneration | Nervous System Disease | - | 0.4 | KE:389 | Increased, Intracellular Calcium overload |
KE:55 | Increase, Cell injury/death | |||||
KE:352 | N/A, Neurodegeneration | |||||
KE:1350 | Increased, glutamate | |||||
AOP:286 | Mitochondrial complex III antagonism leading to growth inhibition (1) | Unclassified | - | 0.75 | KE:1821 | Decrease, Cell proliferation |
KE:1771 | Decrease, Adenosine triphosphate pool | |||||
KE:1521 | Decrease, Growth | |||||
AOP:287 | Mitochondrial complex III antagonism leading to growth inhibition (2) | Unclassified | - | 0.5 | KE:1771 | Decrease, Adenosine triphosphate pool |
KE:1521 | Decrease, Growth | |||||
AOP:290 | Mitochondrial ATP synthase antagonism leading to growth inhibition (1) | Unclassified | - | 0.75 | KE:1821 | Decrease, Cell proliferation |
KE:1771 | Decrease, Adenosine triphosphate pool | |||||
KE:1521 | Decrease, Growth | |||||
AOP:291 | Mitochondrial ATP synthase antagonism leading to growth inhibition (2) | Unclassified | - | 0.5 | KE:1771 | Decrease, Adenosine triphosphate pool |
KE:1521 | Decrease, Growth | |||||
AOP:296 | Oxidative DNA damage leading to chromosomal aberrations and mutations | Genetic Disease; Chromosomal Disease | WPHA/WNT Endorsed | 0.4 | KE:155 | Inadequate DNA repair |
KE:1636 | Increase, Chromosomal aberrations | |||||
AOP:300 | Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals | Cognitive Disorder | Under Development | 0.6 | KE:758 | Hippocampal Physiology, Altered |
KE:402 | Cognitive function, decreased | |||||
KE:756 | Hippocampal gene expression, Altered | |||||
AOP:303 | Frustrated phagocytosis-induced lung cancer | Cancer | Under Development | 0.57 | KE:1115 | Increase, Reactive oxygen species |
KE:870 | Increase, Cell Proliferation | |||||
KE:1497 | Increased, recruitment of inflammatory cells | |||||
KE:1670 | Lung cancer | |||||
AOP:322 | Alkylation of DNA leading to reduced sperm count | Reproductive System Disease | - | 0.4 | KE:1757 | Reduce, Sperm count |
KE:155 | Inadequate DNA repair | |||||
AOP:323 | PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone | Unclassified | - | 0.33 | KE:2147 | Decreased, Viable Offspring |
KE:807 | Decreased, cholesterol | |||||
AOP:384 | Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease | Urinary System Disease | - | 0.33 | KE:1115 | Increase, Reactive oxygen species |
KE:1603 | Chronic kidney disease | |||||
AOP:392 | Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation | Unclassified | Under Development | 0.6 | KE:1868 | Hyperinflammation |
KE:1497 | Increased, recruitment of inflammatory cells | |||||
KE:1496 | Increased, secretion of proinflammatory mediators | |||||
AOP:405 | Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function | Cognitive Disorder | - | 0.2 | KE:402 | Cognitive function, decreased |
AOP:406 | SARS-CoV-2 infection leading to hyperinflammation | Unclassified | - | 0.33 | KE:1868 | Hyperinflammation |
KE:1869 | Diminished protective oxidative stress response | |||||
AOP:416 | Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway | Cancer | - | 0.33 | KE:1115 | Increase, Reactive oxygen species |
KE:1670 | Lung cancer | |||||
AOP:417 | Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway | Cancer | - | 0.2 | KE:1670 | Lung cancer |
AOP:420 | Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway | Cancer | - | 0.5 | KE:870 | Increase, Cell Proliferation |
KE:1670 | Lung cancer | |||||
AOP:431 | Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) | Inherited Metabolic Disorder | - | 0.4 | KE:1953 | Gestational diabetes mellitus |
KE:1952 | Abnormal, Glucose homeostasis | |||||
AOP:433 | hERG channel blockade leading to sudden cardiac death | Cardiovascular System Disease | - | 0.67 | KE:1961 | Prolongation of Action Potential Duration |
KE:1962 | Prolongation of QT interval | |||||
KE:1963 | Torsades de Pointes | |||||
KE:1964 | Sudden cardiac death | |||||
AOP:437 | Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity | Urinary System Disease | Under Development | 0.4 | KE:177 | Mitochondrial dysfunction |
KE:814 | Occurrence, Kidney toxicity | |||||
AOP:442 | Binding to voltage gate sodium channels during development leads to cognitive impairment | Cognitive Disorder | Under Review | 0.29 | KE:758 | Hippocampal Physiology, Altered |
KE:402 | Cognitive function, decreased | |||||
AOP:450 | Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality | Nervous System Disease | - | 0.29 | KE:1583 | Sensory axonal peripheral neuropathy |
KE:352 | N/A, Neurodegeneration | |||||
AOP:451 | Interaction with lung resident cell membrane components leads to lung cancer | Cancer | - | 0.56 | KE:870 | Increase, Cell Proliferation |
KE:1670 | Lung cancer | |||||
KE:1496 | Increased, secretion of proinflammatory mediators | |||||
KE:1115 | Increase, Reactive oxygen species | |||||
KE:1497 | Increased, recruitment of inflammatory cells | |||||
AOP:455 | Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development | Musculoskeletal System Disease | Under Review | 0.67 | KE:2020 | Decrease, sox9 expression |
KE:947 | Increase, Early Life Stage Mortality | |||||
KE:2021 | Increase, slincR expression | |||||
KE:1559 | Facial cartilage structures are reduced in size and morphologically distorted | |||||
AOP:456 | Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity | Unclassified | Under Review | 0.67 | KE:2020 | Decrease, sox9 expression |
KE:317 | Altered, Cardiovascular development/function | |||||
KE:947 | Increase, Early Life Stage Mortality | |||||
KE:2021 | Increase, slincR expression | |||||
AOP:457 | Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine | Inherited Metabolic Disorder | - | 0.33 | KE:277 | Thyroid hormone synthesis, Decreased |
KE:2119 | Insulin resistance, increased | |||||
AOP:458 | AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals | Cognitive Disorder | - | 0.38 | KE:758 | Hippocampal Physiology, Altered |
KE:402 | Cognitive function, decreased | |||||
KE:756 | Hippocampal gene expression, Altered | |||||
AOP:459 | AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals | Cognitive Disorder | - | 0.56 | KE:758 | Hippocampal Physiology, Altered |
KE:850 | Induction, CYP1A2/CYP1A5 | |||||
KE:402 | Cognitive function, decreased | |||||
KE:277 | Thyroid hormone synthesis, Decreased | |||||
KE:756 | Hippocampal gene expression, Altered | |||||
AOP:468 | Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) | Unclassified | - | 0.38 | KE:1868 | Hyperinflammation |
KE:1497 | Increased, recruitment of inflammatory cells | |||||
KE:1496 | Increased, secretion of proinflammatory mediators | |||||
AOP:474 | Succinate dehydrogenase inactivation leads to cancer by promoting EMT | Cancer | Under Development | 0.2 | KE:885 | Increase, Cancer |
AOP:475 | Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons | Developmental Disorder Of Mental Health | Under Development | 0.25 | KE:389 | Increased, Intracellular Calcium overload |
KE:341 | Impairment, Learning and memory | |||||
AOP:483 | Deposition of Energy Leading to Learning and Memory Impairment | Developmental Disorder Of Mental Health | Under Review | 0.12 | KE:341 | Impairment, Learning and memory |
AOP:485 | Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition | Cognitive Disorder | - | 0.14 | KE:402 | Cognitive function, decreased |
AOP:486 | Binding to the extracellular protein laminin leading to decreased cognitive function | Cognitive Disorder | - | 0.14 | KE:402 | Cognitive function, decreased |
AOP:490 | Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms | Developmental Disorder Of Mental Health | - | 0.55 | KE:2121 | decreased, Intellectual Quotient |
KE:758 | Hippocampal Physiology, Altered | |||||
KE:188 | Neuroinflammation | |||||
KE:1350 | Increased, glutamate | |||||
KE:55 | Increase, Cell injury/death | |||||
KE:341 | Impairment, Learning and memory | |||||
AOP:493 | ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity | Acquired Metabolic Disease | - | 0.4 | KE:2129 | Metabolically unhealthy Obesity |
KE:1497 | Increased, recruitment of inflammatory cells | |||||
KE:2125 | Increased fat mass | |||||
KE:2119 | Insulin resistance, increased | |||||
AOP:497 | ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome | Inherited Metabolic Disorder; Disease Of Metabolism | - | 0.5 | KE:1115 | Increase, Reactive oxygen species |
KE:177 | Mitochondrial dysfunction | |||||
KE:2145 | Metabolic syndrome | |||||
KE:2119 | Insulin resistance, increased | |||||
AOP:498 | Increased LCN2/iron complex leading to neurological disorders | Nervous System Disease | - | 0.5 | KE:191 | Neuronal dysfunction |
KE:2150 | Neurological disorder | |||||
AOP:501 | Excessive iron accumulation leading to neurological disorders | Nervous System Disease | - | 0.25 | KE:2150 | Neurological disorder |
AOP:507 | Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway | Cardiovascular System Disease | - | 0.17 | KE:2161 | Increase, Vascular disrupting effects |
AOP:508 | Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway | Cardiovascular System Disease | - | 0.14 | KE:2161 | Increase, Vascular disrupting effects |
AOP:509 | Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction | Cardiovascular System Disease | - | 0.29 | KE:177 | Mitochondrial dysfunction |
KE:2161 | Increase, Vascular disrupting effects | |||||
AOP:510 | Demethylation of PPAR promotor leading to vascular disrupting effects | Cardiovascular System Disease | - | 0.1 | KE:2161 | Increase, Vascular disrupting effects |
AOP:520 | Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory | Developmental Disorder Of Mental Health | - | 0.4 | KE:2204 | Altered brain morphology |
KE:341 | Impairment, Learning and memory | |||||
AOP:521 | Essential element imbalance leads to reproductive failure via oxidative stress | Unclassified | - | 0.43 | KE:1115 | Increase, Reactive oxygen species |
KE:2147 | Decreased, Viable Offspring | |||||
KE:2206 | Increased, histomorphological alteration of testis | |||||
AOP:525 | Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory | Developmental Disorder Of Mental Health | - | 0.08 | KE:341 | Impairment, Learning and memory |
AOP:532 | Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function | Unclassified | - | 0.2 | KE:2231 | Locomotor function. Impaired |
AOP:533 | Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory | Developmental Disorder Of Mental Health | - | 0.33 | KE:341 | Impairment, Learning and memory |
KE:1239 | Altered, Gene Expression | |||||
AOP:534 | Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress | Cancer | - | 0.5 | KE:1115 | Increase, Reactive oxygen species |
KE:885 | Increase, Cancer | |||||
KE:1446 | Decrease, Coupling of oxidative phosphorylation | |||||
AOP:535 | Binding and activation of GPER leading to learning and memory impairments | Developmental Disorder Of Mental Health | - | 0.56 | KE:389 | Increased, Intracellular Calcium overload |
KE:1262 | Apoptosis | |||||
KE:188 | Neuroinflammation | |||||
KE:341 | Impairment, Learning and memory | |||||
KE:2151 | Disruption, neurotransmitter release | |||||
AOP:546 | Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms | Cancer | - | 0.2 | KE:885 | Increase, Cancer |
AOP:550 | Increased LMNA gene mutation leading to heart failure | Cardiovascular System Disease | - | 0.2 | KE:1535 | Heart failure |
AOP:551 | Increased Muscarinic M2 Receptor leading to Arrhythmia | Symptom | - | 0.2 | KE:1106 | Occurrence, cardiac arrhythmia |
AOP:553 | Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure | Cardiovascular System Disease | - | 0.75 | KE:698 | Altered, Action Potential |
KE:1532 | Decrease, Cardiac contractility | |||||
KE:1535 | Heart failure | |||||
AOP:554 | β-adrenergic receptor agonists leading to arrhythmias. | Symptom | - | 0.25 | KE:1106 | Occurrence, cardiac arrhythmia |
AOP:559 | Inhibition of acetylcholinesterase (AChE) leading to arrhythmias | Symptom | - | 0.4 | KE:698 | Altered, Action Potential |
KE:1106 | Occurrence, cardiac arrhythmia | |||||
AOP:562 | HCN Channel Inhibition leading to Arrhythmias | Symptom | - | 0.6 | KE:1106 | Occurrence, cardiac arrhythmia |
KE:2291 | Slowed Heart Rate | |||||
KE:2292 | Altered Cardiac Electrical Conduction | |||||
AOP:569 | Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway | Developmental Disorder Of Mental Health | - | 0.5 | KE:2121 | decreased, Intellectual Quotient |
KE:1115 | Increase, Reactive oxygen species | |||||
KE:2195 | Increase, CNS Neural cell death |
AOP Identifier | AOP Title | AO Classification | OECD Status | Coverage Score | KE Identifier | KE Name |
---|---|---|---|---|---|---|
AOP:39 | Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response | Respiratory System Disease | Under Development | 0.6 | KE:396 | Covalent Binding, Protein |
KE:1496 | Increased, secretion of proinflammatory mediators | |||||
KE:272 | Activation/Proliferation, T-cells | |||||
AOP:62 | AKT2 activation leading to hepatic steatosis | Gastrointestinal System Disease; Inherited Metabolic Disorder | - | 0.25 | KE:486 | systemic inflammation leading to hepatic steatosis |
AOP:69 | Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell | Reproductive System Disease | - | 0.2 | KE:642 | Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol |
AOP:112 | Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) | Reproductive System Disease; Cancer | - | 0.17 | KE:746 | Increase, Dopaminergic activity |
AOP:118 | Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) | Cancer; Gastrointestinal System Disease | - | 0.5 | KE:786 | Increase, Cytotoxicity (hepatocytes) |
KE:787 | Increase, Regenerative cell proliferation (hepatocytes) | |||||
AOP:121 | Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) | Cancer; Urinary System Disease | - | 0.4 | KE:795 | Increase, Regenerative cell proliferation (urothelial cells) |
KE:793 | Increase, Urinary bladder calculi | |||||
AOP:209 | Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP | Gastrointestinal System Disease | - | 0.38 | KE:1287 | Glutathione synthesis |
KE:1286 | Down Regulation, GSS and GSTs gene | |||||
KE:1284 | Up Regulation, SREBF2 | |||||
AOP:282 | Adverse outcome pathway on photochemical toxicity initiated by light exposure | Unclassified | Under Review | 0.25 | KE:1115 | Increase, Reactive oxygen species |
AOP:298 | Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer via chronic ROS | Cancer; Gastrointestinal System Disease | Under Review | 0.33 | KE:1115 | Increase, Reactive oxygen species |
KE:1753 | Chronic reactive oxygen species | |||||
AOP:327 | Excessive reactive oxygen species production leading to mortality (1) | Unclassified | - | 0.4 | KE:1115 | Increase, Reactive oxygen species |
KE:1769 | Increase, Body fluid overload | |||||
AOP:328 | Excessive reactive oxygen species production leading to mortality (2) | Unclassified | - | 0.4 | KE:1115 | Increase, Reactive oxygen species |
KE:1771 | Decrease, Adenosine triphosphate pool | |||||
AOP:329 | Excessive reactive oxygen species production leading to mortality (3) | Unclassified | - | 0.4 | KE:1115 | Increase, Reactive oxygen species |
KE:1771 | Decrease, Adenosine triphosphate pool | |||||
AOP:330 | Excessive reactive oxygen species production leading to mortality (4) | Unclassified | - | 0.2 | KE:1115 | Increase, Reactive oxygen species |
AOP:335 | AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment | Cancer; Urinary System Disease | - | 0.4 | KE:795 | Increase, Regenerative cell proliferation (urothelial cells) |
KE:177 | Mitochondrial dysfunction | |||||
AOP:423 | Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway | Unclassified | - | 0.33 | KE:1115 | Increase, Reactive oxygen species |
KE:177 | Mitochondrial dysfunction | |||||
AOP:438 | reactive oxygen species generation leading to increased cardiovascular morbidity and mortality | Cardiovascular System Disease | - | 0.17 | KE:1115 | Increase, Reactive oxygen species |
KE:177 | Mitochondrial dysfunction | |||||
AOP:446 | PM-related Adverse outcome pathway frameworks on various systems | Respiratory System Disease | - | 0.35 | KE:1262 | Apoptosis |
KE:149 | Increase, Inflammation | |||||
KE:1496 | Increased, secretion of proinflammatory mediators | |||||
KE:1115 | Increase, Reactive oxygen species | |||||
KE:1239 | Altered, Gene Expression | |||||
KE:1497 | Increased, recruitment of inflammatory cells | |||||
KE:1198 | Activation, Macrophages | |||||
AOP:448 | ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality | Cardiovascular System Disease | - | 0.18 | KE:1443 | Atherosclerosis |
KE:1115 | Increase, Reactive oxygen species | |||||
KE:1198 | Activation, Macrophages | |||||
AOP:453 | Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population | Gastrointestinal System Disease | - | 0.23 | KE:1995 | Abnormal lipid metabolism |
KE:1115 | Increase, Reactive oxygen species | |||||
KE:1198 | Activation, Macrophages | |||||
AOP:463 | The AOP framwork on silica nanopariticles induced hepatoxicity | Gastrointestinal System Disease | - | 0.36 | KE:149 | Increase, Inflammation |
KE:177 | Mitochondrial dysfunction | |||||
KE:1262 | Apoptosis | |||||
KE:1115 | Increase, Reactive oxygen species | |||||
AOP:469 | Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population | Gastrointestinal System Disease | - | 0.23 | KE:1995 | Abnormal lipid metabolism |
KE:1115 | Increase, Reactive oxygen species | |||||
KE:1198 | Activation, Macrophages | |||||
AOP:491 | Decrease, GLI1/2 target gene expression leads to orofacial clefting | Unclassified | Under Development | 0.5 | KE:1821 | Decrease, Cell proliferation |
KE:1262 | Apoptosis | |||||
KE:2040 | Decrease, GLI1/2 target gene expression | |||||
AOP:540 | Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production | Unclassified | - | 0.44 | KE:3 | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells |
KE:1115 | Increase, Reactive oxygen species | |||||
KE:1262 | Apoptosis | |||||
KE:285 | Reduction, Vitellogenin synthesis in liver | |||||
AOP:541 | Excessive ROS generation leading to increased incidence of vascular calcification by VSMC phenotype switching | Cardiovascular System Disease | - | 0.23 | KE:1115 | Increase, Reactive oxygen species |
KE:1493 | Increased Pro-inflammatory mediators | |||||
KE:1198 | Activation, Macrophages |
AOP Identifier | AOP Title | AO Classification | OECD Status | Coverage Score | KE Identifier | KE Name |
---|---|---|---|---|---|---|
AOP:12 | Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging | Nervous System Disease; Developmental Disorder Of Mental Health | WPHA/WNT Endorsed | 1.0 | KE:195 | Inhibition, NMDARs |
KE:188 | Neuroinflammation | |||||
KE:52 | Decreased, Calcium influx | |||||
KE:201 | Binding of antagonist, NMDA receptors | |||||
KE:341 | Impairment, Learning and memory | |||||
KE:352 | N/A, Neurodegeneration | |||||
KE:55 | Increase, Cell injury/death | |||||
KE:381 | Reduced levels of BDNF | |||||
AOP:13 | Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities | Developmental Disorder Of Mental Health | WPHA/WNT Endorsed | 0.6 | KE:195 | Inhibition, NMDARs |
KE:52 | Decreased, Calcium influx | |||||
KE:201 | Binding of antagonist, NMDA receptors | |||||
KE:341 | Impairment, Learning and memory | |||||
KE:55 | Increase, Cell injury/death | |||||
KE:381 | Reduced levels of BDNF | |||||
AOP:40 | Covalent Protein binding leading to Skin Sensitisation | Integumentary System Disease | WPHA/WNT Endorsed | 0.8 | KE:827 | sensitisation, skin |
KE:826 | Activation, Keratinocytes | |||||
KE:396 | Covalent Binding, Protein | |||||
KE:272 | Activation/Proliferation, T-cells | |||||
AOP:95 | Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival | Unclassified | - | 0.33 | KE:592 | Reduced, survival |
KE:593 | Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel | |||||
AOP:128 | Kidney dysfunction by decreased thyroid hormone | Urinary System Disease | Under Development | 0.36 | KE:277 | Thyroid hormone synthesis, Decreased |
KE:821 | Decreased, Sodium reabsorption | |||||
KE:825 | Decreased, Renal ability to dilute urine | |||||
KE:814 | Occurrence, Kidney toxicity | |||||
AOP:205 | AOP from chemical insult to cell death | Unclassified | - | 0.5 | KE:1259 | narcosis |
KE:177 | Mitochondrial dysfunction | |||||
KE:1262 | Apoptosis | |||||
AOP:261 | L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility | Cardiovascular System Disease | Under Development | 0.38 | KE:1529 | Blockade, L-Type Calcium Channels |
KE:1532 | Decrease, Cardiac contractility | |||||
KE:1535 | Heart failure | |||||
AOP:263 | Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation | Unclassified | WPHA/WNT Endorsed | 1.0 | KE:1821 | Decrease, Cell proliferation |
KE:1771 | Decrease, Adenosine triphosphate pool | |||||
KE:1446 | Decrease, Coupling of oxidative phosphorylation | |||||
KE:1521 | Decrease, Growth | |||||
AOP:264 | Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death | Unclassified | Under Development | 1.0 | KE:1771 | Decrease, Adenosine triphosphate pool |
KE:55 | Increase, Cell injury/death | |||||
KE:1446 | Decrease, Coupling of oxidative phosphorylation | |||||
KE:1521 | Decrease, Growth | |||||
AOP:265 | Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium | Unclassified | Under Development | 0.75 | KE:1521 | Decrease, Growth |
KE:55 | Increase, Cell injury/death | |||||
KE:1446 | Decrease, Coupling of oxidative phosphorylation | |||||
AOP:266 | Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity | Unclassified | Under Development | 0.83 | KE:1521 | Decrease, Growth |
KE:1562 | Decreased Na/K ATPase activity | |||||
KE:1771 | Decrease, Adenosine triphosphate pool | |||||
KE:1446 | Decrease, Coupling of oxidative phosphorylation | |||||
KE:55 | Increase, Cell injury/death | |||||
AOP:267 | Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion | Unclassified | Under Development | 0.6 | KE:1821 | Decrease, Cell proliferation |
KE:1521 | Decrease, Growth | |||||
KE:1446 | Decrease, Coupling of oxidative phosphorylation | |||||
AOP:268 | Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling | Unclassified | Under Development | 0.75 | KE:1521 | Decrease, Growth |
KE:55 | Increase, Cell injury/death | |||||
KE:1446 | Decrease, Coupling of oxidative phosphorylation | |||||
AOP:324 | Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death | Unclassified | - | 0.75 | KE:1115 | Increase, Reactive oxygen species |
KE:1521 | Decrease, Growth | |||||
KE:55 | Increase, Cell injury/death | |||||
AOP:325 | Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death | Unclassified | - | 0.75 | KE:1115 | Increase, Reactive oxygen species |
KE:1521 | Decrease, Growth | |||||
KE:55 | Increase, Cell injury/death | |||||
AOP:326 | Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell death | Unclassified | - | 0.75 | KE:1115 | Increase, Reactive oxygen species |
KE:1521 | Decrease, Growth | |||||
KE:55 | Increase, Cell injury/death | |||||
AOP:331 | Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage and reduced cell proliferation | Unclassified | - | 0.5 | KE:1821 | Decrease, Cell proliferation |
KE:1115 | Increase, Reactive oxygen species | |||||
KE:1521 | Decrease, Growth | |||||
AOP:332 | Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation | Unclassified | - | 0.6 | KE:1821 | Decrease, Cell proliferation |
KE:1115 | Increase, Reactive oxygen species | |||||
KE:1521 | Decrease, Growth | |||||
AOP:333 | Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation | Unclassified | - | 1.0 | KE:1521 | Decrease, Growth |
KE:1115 | Increase, Reactive oxygen species | |||||
KE:1771 | Decrease, Adenosine triphosphate pool | |||||
KE:1446 | Decrease, Coupling of oxidative phosphorylation | |||||
KE:1821 | Decrease, Cell proliferation | |||||
AOP:447 | Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways | Urinary System Disease | - | 0.25 | KE:177 | Mitochondrial dysfunction |
KE:814 | Occurrence, Kidney toxicity | |||||
KE:759 | Increased, Kidney Failure | |||||
AOP:472 | DNA adduct formation leading to kidney failure | Urinary System Disease | - | 0.33 | KE:149 | Increase, Inflammation |
KE:1115 | Increase, Reactive oxygen species | |||||
KE:759 | Increased, Kidney Failure | |||||
AOP:488 | Increased reactive oxygen species production leading to decreased cognitive function | Cognitive Disorder | - | 0.43 | KE:1115 | Increase, Reactive oxygen species |
KE:1869 | Diminished protective oxidative stress response | |||||
KE:402 | Cognitive function, decreased | |||||
AOP:499 | Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release | Developmental Disorder Of Mental Health | - | 1.0 | KE:2146 | Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 |
KE:1339 | Increase, intracellular calcium | |||||
KE:341 | Impairment, Learning and memory | |||||
KE:2151 | Disruption, neurotransmitter release | |||||
AOP:500 | Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis | Developmental Disorder Of Mental Health | - | 1.0 | KE:1262 | Apoptosis |
KE:2146 | Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 | |||||
KE:177 | Mitochondrial dysfunction | |||||
KE:1115 | Increase, Reactive oxygen species | |||||
KE:352 | N/A, Neurodegeneration | |||||
KE:1339 | Increase, intracellular calcium | |||||
KE:341 | Impairment, Learning and memory | |||||
AOP:505 | Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway | Cancer | - | 0.6 | KE:149 | Increase, Inflammation |
KE:1115 | Increase, Reactive oxygen species | |||||
KE:885 | Increase, Cancer | |||||
AOP:511 | The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects | Cardiovascular System Disease | - | 0.19 | KE:1115 | Increase, Reactive oxygen species |
KE:2161 | Increase, Vascular disrupting effects | |||||
KE:177 | Mitochondrial dysfunction | |||||
AOP:513 | Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway | Cancer | - | 0.6 | KE:1115 | Increase, Reactive oxygen species |
KE:1060 | Alteration, lipid metabolism | |||||
KE:885 | Increase, Cancer | |||||
AOP:539 | Decreased Sodium/Potassium ATPase activity leads to Heart failure | Cardiovascular System Disease | - | 0.43 | KE:1562 | Decreased Na/K ATPase activity |
KE:2261 | Decreased, blood plasma volume | |||||
KE:1535 | Heart failure | |||||
AOP:552 | Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) | Cardiovascular System Disease | - | 1.0 | KE:698 | Altered, Action Potential |
KE:2281 | Increased uncoordinated cardiac contraction | |||||
KE:1529 | Blockade, L-Type Calcium Channels | |||||
KE:1963 | Torsades de Pointes | |||||
KE:1535 | Heart failure | |||||
KE:1962 | Prolongation of QT interval | |||||
AOP:555 | Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure | Cardiovascular System Disease | - | 1.0 | KE:2283 | Increased the early premature depolarizations during repolarization |
KE:1961 | Prolongation of Action Potential Duration | |||||
KE:593 | Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel | |||||
KE:1535 | Heart failure | |||||
KE:1962 | Prolongation of QT interval | |||||
AOP:556 | Decreased Na/K ATPase activity leading to heart failure | Cardiovascular System Disease | - | 1.0 | KE:389 | Increased, Intracellular Calcium overload |
KE:1532 | Decrease, Cardiac contractility | |||||
KE:1321 | Increased, intracellular sodium (Na+) | |||||
KE:1562 | Decreased Na/K ATPase activity | |||||
KE:2287 | Impaired Sodium-Calcium Exchange | |||||
KE:1535 | Heart failure | |||||
AOP:558 | Phosphodiesterase inhibition leading to heart failure | Cardiovascular System Disease | - | 1.0 | KE:389 | Increased, Intracellular Calcium overload |
KE:1532 | Decrease, Cardiac contractility | |||||
KE:2289 | Hyperphosphorylation of ryanodine receptor (RyR2) | |||||
KE:2288 | Phosphodiesterase inhibition | |||||
KE:1535 | Heart failure | |||||
KE:693 | Increased, cyclic adenosine monophosphate | |||||
AOP:560 | Inhibition of Funny current (If) leading to Arrhythmias | Symptom | - | 1.0 | KE:1106 | Occurrence, cardiac arrhythmia |
KE:2290 | Inhibition of Funny current (If) | |||||
KE:2291 | Slowed Heart Rate | |||||
KE:2292 | Altered Cardiac Electrical Conduction |
TICToK is a database of tattoo ink chemicals compiled from different regulatory resources. The authors are not liable for any inaccuracies or omissions of any chemicals in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.