TICToK | Tattoo Ink Chemicals and assocaited Toxicities Knowledgebase

Castor oil

Castor oil

Associated High Confidence AOPs

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Associated AOPs with Level of Relevance 1

AOP Identifier	AOP Title	AO Classification	OECD Status	Coverage Score	KE Identifier	KE Name
AOP:288	Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)	Endocrine System Disease	-	0.12	KE:1614	Decrease, androgen receptor activation
AOP:305	5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring	Unclassified	Under Development	0.4	KE:1614	Decrease, androgen receptor activation
AOP:305		Unclassified	Under Development	0.4	KE:286	Altered, Transcription of genes by the androgen receptor
AOP:495	Androgen receptor activation leading to prostate cancer	Reproductive System Disease; Cancer	-	0.11	KE:286	Altered, Transcription of genes by the androgen receptor
AOP:496	Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）	Unclassified	-	0.1	KE:286	Altered, Transcription of genes by the androgen receptor

No associated AOPs with Level of Relevance 2

Associated AOPs with Level of Relevance 3

AOP Identifier	AOP Title	AO Classification	OECD Status	Coverage Score	KE Identifier	KE Name
AOP:19	Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)	Reproductive System Disease	-	0.4	KE:26	Antagonism, Androgen receptor
AOP:19		Reproductive System Disease	-	0.4	KE:286	Altered, Transcription of genes by the androgen receptor
AOP:111	Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)	Cancer; Reproductive System Disease	-	0.2	KE:1614	Decrease, androgen receptor activation
AOP:306	Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring	Unclassified	Under Development	0.75	KE:1614	Decrease, androgen receptor activation
					KE:26	Antagonism, Androgen receptor
					KE:286	Altered, Transcription of genes by the androgen receptor
AOP:344	Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring	Unclassified	Under Development	0.75	KE:1614	Decrease, androgen receptor activation
					KE:26	Antagonism, Androgen receptor
					KE:286	Altered, Transcription of genes by the androgen receptor
AOP:345	Androgen receptor (AR) antagonism leading to decreased fertility in females	Endocrine System Disease; Reproductive System Disease; Reproductive System Disease	Under Development	0.5	KE:1614	Decrease, androgen receptor activation
					KE:26	Antagonism, Androgen receptor
					KE:286	Altered, Transcription of genes by the androgen receptor
AOP:372	Androgen receptor antagonism leading to testicular cancer	Endocrine System Disease; Reproductive System Disease; Cancer	-	0.6	KE:1614	Decrease, androgen receptor activation
					KE:26	Antagonism, Androgen receptor
					KE:286	Altered, Transcription of genes by the androgen receptor
AOP:477	Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring	Physical Disorder	-	0.67	KE:1614	Decrease, androgen receptor activation
AOP:477		Physical Disorder	-	0.67	KE:26	Antagonism, Androgen receptor

No associated AOPs with Level of Relevance 5

DISCLAIMER

TICToK is a database of tattoo ink chemicals compiled from different regulatory resources. The authors are not liable for any inaccuracies or omissions of any chemicals in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.