TICToK | Tattoo Ink Chemicals and assocaited Toxicities Knowledgebase

4-Chloroaniline

4-Chloroaniline

ToxCast Endpoints

For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the DOWNLOAD page.

ToxCast Endpoints for intended target type: RNA

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
LTEA_HepaRG_CYP1A1	Liver	1543	CYP1A1	P04798	Activatory	28.01 μM
LTEA_HepaRG_CYP1A2	Liver	1544	CYP1A2	P05177	Activatory	33.45 μM
LTEA_HepaRG_UGT1A1	Liver	54658	UGT1A1	P22309	Activatory	36.52 μM

ToxCast Endpoints for intended target type: Protein

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
TOX21_ERa_BLA_Antagonist_ratio	Kidney	2099	ESR1	P03372	Loss	58.61 μM
TOX21_AhR_LUC_Agonist	Liver	196	AHR	P35869	Gain	57.31 μM
TOX21_ERR_LUC_Antagonist	Kidney	2101	ESRRA	P11474	Loss	13.64 μM
TOX21_ERb_BLA_Antagonist_ratio	Kidney	2100	ESR2	Q92731	Loss	3.42 μM
TOX21_p450_CYP2D6_Antagonist		1565	CYP2D6	P10635	Loss	59.19 μM
TOX21_p450_CYP2C19_Antagonist		1557	CYP2C19	P33261	Loss	45.47 μM
TOX21_p450_CYP2C9_Antagonist		1559	CYP2C9	P11712	Loss	66.94 μM
TOX21_p450_CYP1A2_Antagonist		1544	CYP1A2	P05177	Loss	47.42 μM

No ToxCast endpoints for intended target type: Molecular Messengers

ToxCast Endpoints for intended target type: Pathway

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
OT_FXR_FXRSRC1_1440	Kidney	6714\|9971	NR1H4\|SRC	P12931\|Q96RI1	Gain	1.96 μM
OT_NURR1_NURR1RXRa_1440	Kidney	4929\|6256	NR4A2\|RXRA	P19793\|P43354	Gain	2.33 μM
ACEA_AR_antagonist_80hr	Prostate	367	AR	P10275	Loss	18.15 μM

ToxCast Endpoints for intended target type: Cellular

Assay Name	Tissue	Response	AC50 value
BSK_3C_Proliferation	Vascular	Inhibitory	13.20 μM
BSK_hDFCGF_Proliferation	Skin	Inhibitory	7.71 μM
ACEA_AR_agonist_AUC_viability	Prostate	Loss	5.62 μM
ACEA_AR_antagonist_AUC_viability	Prostate	Loss	8.97 μM

No ToxCast endpoints for intended target type: Extracellular

DISCLAIMER

TICToK is a database of tattoo ink chemicals compiled from different regulatory resources. The authors are not liable for any inaccuracies or omissions of any chemicals in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.