For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the
DOWNLOAD page.
ToxCast Endpoints for intended target type: RNA
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
LTEA_HepaRG_BCL2L11 | Liver | 10018 | BCL2L11 | O43521 | Inhibitory | 0.00 μM |
LTEA_HepaRG_CYP1A1 | Liver | 1543 | CYP1A1 | P04798 | Activatory | 76.58 μM |
LTEA_HepaRG_GADD45A | Liver | 1647 | GADD45A | P24522 | Inhibitory | 0.25 μM |
LTEA_HepaRG_GCLC | Liver | 2729 | GCLC | P48506 | Inhibitory | 0.26 μM |
LTEA_HepaRG_UGT1A1 | Liver | 54658 | UGT1A1 | P22309 | Inhibitory | 0.17 μM |
ToxCast Endpoints for intended target type: Protein
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
TOX21_AR_LUC_MDAKB2_Agonist | Breast | 367 | AR | P10275 | Gain | 45.15 μM |
TOX21_p450_CYP2C19_Antagonist | | 1557 | CYP2C19 | P33261 | Loss | 41.46 μM |
No ToxCast endpoints for intended target type: Molecular Messengers
ToxCast Endpoints for intended target type: Pathway
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
UPITT_HCI_U2OS_AR_TIF2_Nucleoli_Antagonist | Bone | 367 | AR | P10275 | Loss | 76.24 μM |
APR_HepG2_CellCycleArrest_72hr | Liver | | | | Inhibitory | 71.54 μM |
APR_HepG2_MitoticArrest_72hr | Liver | 3020 | H3F3A | P84243 | Activatory | 98.15 μM |
APR_HepG2_P-H2AX_72hr | Liver | 3014 | H2AFX | P16104 | Activatory | 93.04 μM |
APR_HepG2_p53Act_72hr | Liver | 7157 | TP53 | P04637 | Activatory | 80.38 μM |
ACEA_AR_antagonist_80hr | Prostate | 367 | AR | P10275 | Loss | 82.49 μM |
TOX21_ARE_BLA_Agonist_ratio | Liver | 4780 | NFE2L2 | Q16236 | Gain | 15.75 μM |
TOX21_RXR_BLA_Agonist_ch2 | Kidney | | | | Gain | 49.50 μM |
TOX21_RXR_BLA_Agonist_ratio | Kidney | 6256 | RXRA | P19793 | Gain | 48.43 μM |
ToxCast Endpoints for intended target type: Cellular
Assay Name | Tissue | Response | AC50 value |
---|
APR_HepG2_CellLoss_72hr | Liver | Inhibitory | 83.71 μM |
APR_HepG2_MitoMass_72hr | Liver | Activatory | 47.48 μM |
APR_HepG2_NuclearSize_72hr | Liver | Activatory | 60.68 μM |
CCTE_Simmons_CellTiterGLO_HEK293T | Kidney | Loss | 48.78 μM |
No ToxCast endpoints for intended target type: Extracellular