TICToK | Tattoo Ink Chemicals and associated Toxicities Knowledgebase

2E,4E-Hexadienoic acid

2E,4E-Hexadienoic acid

ToxCast Endpoints

For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the DOWNLOAD page.

ToxCast Endpoints for intended target type: RNA

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
LTEA_HepaRG_BCL2L11	Liver	10018	BCL2L11	O43521	Inhibitory	0.00 μM
LTEA_HepaRG_CYP1A1	Liver	1543	CYP1A1	P04798	Activatory	76.58 μM
LTEA_HepaRG_GADD45A	Liver	1647	GADD45A	P24522	Inhibitory	0.25 μM
LTEA_HepaRG_GCLC	Liver	2729	GCLC	P48506	Inhibitory	0.26 μM
LTEA_HepaRG_UGT1A1	Liver	54658	UGT1A1	P22309	Inhibitory	0.17 μM

ToxCast Endpoints for intended target type: Protein

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
TOX21_AR_LUC_MDAKB2_Agonist	Breast	367	AR	P10275	Gain	45.15 μM
TOX21_p450_CYP2C19_Antagonist		1557	CYP2C19	P33261	Loss	41.46 μM

No ToxCast endpoints for intended target type: Molecular Messengers

ToxCast Endpoints for intended target type: Pathway

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
UPITT_HCI_U2OS_AR_TIF2_Nucleoli_Antagonist	Bone	367	AR	P10275	Loss	76.24 μM
APR_HepG2_CellCycleArrest_72hr	Liver				Inhibitory	71.54 μM
APR_HepG2_MitoticArrest_72hr	Liver	3020	H3F3A	P84243	Activatory	98.15 μM
APR_HepG2_P-H2AX_72hr	Liver	3014	H2AFX	P16104	Activatory	93.04 μM
APR_HepG2_p53Act_72hr	Liver	7157	TP53	P04637	Activatory	80.38 μM
ACEA_AR_antagonist_80hr	Prostate	367	AR	P10275	Loss	82.49 μM
TOX21_ARE_BLA_Agonist_ratio	Liver	4780	NFE2L2	Q16236	Gain	15.75 μM
TOX21_RXR_BLA_Agonist_ch2	Kidney				Gain	49.50 μM
TOX21_RXR_BLA_Agonist_ratio	Kidney	6256	RXRA	P19793	Gain	48.43 μM

ToxCast Endpoints for intended target type: Cellular

Assay Name	Tissue	Response	AC50 value
APR_HepG2_CellLoss_72hr	Liver	Inhibitory	83.71 μM
APR_HepG2_MitoMass_72hr	Liver	Activatory	47.48 μM
APR_HepG2_NuclearSize_72hr	Liver	Activatory	60.68 μM
CCTE_Simmons_CellTiterGLO_HEK293T	Kidney	Loss	48.78 μM

No ToxCast endpoints for intended target type: Extracellular

DISCLAIMER

TICToK is a database of tattoo ink chemicals compiled from different regulatory resources. The authors are not liable for any inaccuracies or omissions of any chemicals in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.