ToxCast Endpoints
For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the DOWNLOAD page.

ToxCast Endpoints for intended target type: RNA
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
LTEA_HepaRG_BCL2L11Liver10018BCL2L11O43521Inhibitory0.00 μM
LTEA_HepaRG_CYP1A1Liver1543CYP1A1P04798Activatory76.58 μM
LTEA_HepaRG_GADD45ALiver1647GADD45AP24522Inhibitory0.25 μM
LTEA_HepaRG_GCLCLiver2729GCLCP48506Inhibitory0.26 μM
LTEA_HepaRG_UGT1A1Liver54658UGT1A1P22309Inhibitory0.17 μM

ToxCast Endpoints for intended target type: Protein
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
TOX21_AR_LUC_MDAKB2_AgonistBreast367ARP10275Gain45.15 μM
TOX21_p450_CYP2C19_Antagonist1557CYP2C19P33261Loss41.46 μM

No ToxCast endpoints for intended target type: Molecular Messengers

ToxCast Endpoints for intended target type: Pathway
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
UPITT_HCI_U2OS_AR_TIF2_Nucleoli_AntagonistBone367ARP10275Loss76.24 μM
APR_HepG2_CellCycleArrest_72hrLiverInhibitory71.54 μM
APR_HepG2_MitoticArrest_72hrLiver3020H3F3AP84243Activatory98.15 μM
APR_HepG2_P-H2AX_72hrLiver3014H2AFXP16104Activatory93.04 μM
APR_HepG2_p53Act_72hrLiver7157TP53P04637Activatory80.38 μM
ACEA_AR_antagonist_80hrProstate367ARP10275Loss82.49 μM
TOX21_ARE_BLA_Agonist_ratioLiver4780NFE2L2Q16236Gain15.75 μM
TOX21_RXR_BLA_Agonist_ch2KidneyGain49.50 μM
TOX21_RXR_BLA_Agonist_ratioKidney6256RXRAP19793Gain48.43 μM

ToxCast Endpoints for intended target type: Cellular
Assay NameTissueResponseAC50 value
APR_HepG2_CellLoss_72hrLiverInhibitory83.71 μM
APR_HepG2_MitoMass_72hrLiverActivatory47.48 μM
APR_HepG2_NuclearSize_72hrLiverActivatory60.68 μM
CCTE_Simmons_CellTiterGLO_HEK293TKidneyLoss48.78 μM

No ToxCast endpoints for intended target type: Extracellular
DISCLAIMER

TICToK is a database of tattoo ink chemicals compiled from different regulatory resources. The authors are not liable for any inaccuracies or omissions of any chemicals in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.