ToxCast Endpoints
For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the DOWNLOAD page.

ToxCast Endpoints for intended target type: RNA
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
LTEA_HepaRG_ABCB1Liver5243ABCB1P08183Activatory16.72 μM
LTEA_HepaRG_CYP1A1Liver1543CYP1A1P04798Activatory50.00 μM
LTEA_HepaRG_CYP2B6Liver1555CYP2B6P20813Activatory21.93 μM
LTEA_HepaRG_CYP2C19Liver1557CYP2C19P33261Activatory29.52 μM
LTEA_HepaRG_CYP2E1Liver1571CYP2E1P05181Inhibitory64.66 μM
LTEA_HepaRG_CYP3A4Liver1576CYP3A4P08684Activatory19.37 μM
LTEA_HepaRG_CYP4A11Liver1579CYP4A11Q02928Inhibitory50.00 μM

ToxCast Endpoints for intended target type: Protein
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
ATG_PXRE_CISLiver8856NR1I2O75469Activatory12.73 μM
ATG_PXR_TRANSLiver8856NR1I2O75469Gain11.92 μM
STM_H9_CystineISnorm_percActivatory60.12 μM
STM_H9_OrnithineISnorm_percInhibitory74.99 μM
STM_H9_OrnCyssISnorm_ratioInhibitory63.25 μM
TOX21_Aromatase_LUC_AntagonistBreast1588CYP19A1P11511Loss18.39 μM
TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2Breast2099ESR1P03372Loss45.31 μM
TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881Breast367ARP10275Loss62.47 μM
TOX21_CAR_LUC_AntagonistLiver9970NR1I3Q14994Loss80.57 μM
TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2Breast2099ESR1P03372Loss33.27 μM
TOX21_PXR_LUC_AgonistLiver8856NR1I2O75469Gain45.31 μM
TOX21_p450_CYP3A4_Antagonist1576CYP3A4P08684Loss20.49 μM
TOX21_p450_CYP2D6_Antagonist1565CYP2D6P10635Loss62.82 μM
TOX21_p450_CYP2C19_Antagonist1557CYP2C19P33261Loss4.00 μM
TOX21_p450_CYP2C9_Antagonist1559CYP2C9P11712Loss28.87 μM
TOX21_p450_CYP1A2_Antagonist1544CYP1A2P05177Loss33.86 μM
TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2Breast2099ESR1P03372Loss62.08 μM
TOX21_PR_BLA_Antagonist_ratioKidney5241PGRP06401Loss74.37 μM
TOX21_p450_CYP3A4_Antagonist1576CYP3A4P08684Loss18.78 μM
TOX21_p450_CYP2C19_Antagonist1557CYP2C19P33261Loss4.25 μM
TOX21_p450_CYP2C9_Antagonist1559CYP2C9P11712Loss33.11 μM
TOX21_p450_CYP1A2_Antagonist1544CYP1A2P05177Loss49.77 μM

No ToxCast endpoints for intended target type: Molecular Messengers

ToxCast Endpoints for intended target type: Pathway
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
ACEA_AR_antagonist_80hrProstate367ARP10275Loss50.00 μM
TOX21_ARE_BLA_Agonist_ch2LiverGain85.09 μM
TOX21_ARE_BLA_Agonist_ratioLiver4780NFE2L2Q16236Gain70.56 μM
TOX21_FXR_BLA_Antagonist_ratioKidney9971NR1H4Q96RI1Loss37.67 μM
TOX21_RXR_BLA_Agonist_ch2KidneyGain15.52 μM
TOX21_RXR_BLA_Agonist_ratioKidney6256RXRAP19793Gain17.16 μM
TOX21_PR_BLA_Antagonist_ch2KidneyLoss75.23 μM

ToxCast Endpoints for intended target type: Cellular
Assay NameTissueResponseAC50 value
CCTE_Simmons_MITO_basal_resp_rateLiverActivatory50.00 μM
CCTE_Simmons_MITO_max_resp_rateLiverActivatory37.83 μM
TOX21_MMP_rhodamineLiverLoss59.95 μM
TOX21_MMP_ratioLiverInhibitory61.37 μM
TOX21_PR_BLA_Antagonist_viabilityKidneyLoss86.30 μM

No ToxCast endpoints for intended target type: Extracellular
DISCLAIMER

TICToK is a knowledgebase of chemicals found in tattoo inks, compiled from publicly available regulatory and scientific resources. The chemical classifications presented in this knowledgebase are derived from multiple publicly available resources and are provided solely for informational purposes, and they are neither authoritative nor binding. The authors bear no responsibility for any errors, omissions, or inconsistencies originating from these external sources. Users are advised to exercise independent judgment when interpreting chemical classifications and any other data provided in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.