ToxCast Endpoints
For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the DOWNLOAD page.


ToxCast Endpoints for intended target type: RNA
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
LTEA_HepaRG_ABCG2Liver9429ABCG2Q9UNQ0Activatory4.08 μM
LTEA_HepaRG_CCND2Liver894CCND2P30279Inhibitory5.00 μM
LTEA_HepaRG_CYP1A1Liver1543CYP1A1P04798Activatory24.26 μM
LTEA_HepaRG_CYP1A2Liver1544CYP1A2P05177Activatory50.00 μM
LTEA_HepaRG_CYP2B6Liver1555CYP2B6P20813Activatory6.95 μM
LTEA_HepaRG_CYP2C19Liver1557CYP2C19P33261Activatory4.34 μM
LTEA_HepaRG_CYP2C8Liver1558CYP2C8P10632Activatory4.67 μM
LTEA_HepaRG_CYP2E1Liver1571CYP2E1P05181Inhibitory29.60 μM
LTEA_HepaRG_CYP3A4Liver1576CYP3A4P08684Activatory14.57 μM
LTEA_HepaRG_CYP3A7Liver1551CYP3A7P24462Activatory7.23 μM
LTEA_HepaRG_UGT1A1Liver54658UGT1A1P22309Activatory10.68 μM

ToxCast Endpoints for intended target type: Protein
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
CCTE_Deisenroth_AIME_384WELL_CTox_InactiveMammary Gland/BreastLoss0.08 μM
CCTE_Deisenroth_AIME_96WELL_LUC_InactiveMammary Gland/Breast2099ESR1P03372Gain42.08 μM
ATG_Ahr_CISLiver196AHRP35869Inhibitory68.65 μM
ATG_DR5_RAR_CISLiver5916|5915|5914RARG|RARB|RARAP10826|P10276|P13631Activatory7.90 μM
ATG_PXRE_CISLiver8856NR1I2O75469Activatory8.77 μM
ATG_RXRb_TRANSLiver6257RXRBP28702Gain41.35 μM
BSK_3C_TissueFactorVascular2152F3P13726Inhibitory5.47 μM
BSK_4H_VCAM1Vascular7412VCAM1P19320Inhibitory15.52 μM
BSK_CASM3C_LDLRVascular3949LDLRP01130Inhibitory9.87 μM
BSK_SAg_CD38Vascular952CD38P28907Inhibitory11.51 μM
BSK_SAg_CD40Vascular958CD40P25942Inhibitory20.80 μM
BSK_SAg_CD69Vascular969CD69Q07108Inhibitory4.13 μM
ATG_trERa_XSP2Liver101933533ESR1B6E1V9Gain27.79 μM
ATG_hERb_XSP2Liver2100ESR2Q92731Gain0.75 μM
ATG_chERa_XSP2Liver396099ESR1P06212Gain25.35 μM
ATG_frER1_XSP2Liver398734esr1.LQ6W5G7Gain19.84 μM
ATG_zfER2b_XSP2Liver317733esr2bQ5PR29Gain37.08 μM
ATG_hERa_XSP2Liver2099ESR1P03372Gain19.84 μM
ATG_frER2_XSP2Liver100174814esr2.LA0A1L8FA50Gain5.72 μM
ATG_mPPARg_XSP2Liver19016PpargP37238Gain27.93 μM
ATG_mPXR_XSP2Liver8856NR1I2O75469Gain15.00 μM
ATG_trERa_XSP2Liver101933533ESR1B6E1V9Gain166.99 μM
ATG_chERa_XSP2Liver396099ESR1P06212Gain13.87 μM
ATG_frER1_XSP2Liver398734esr1.LQ6W5G7Gain39.85 μM
ATG_zfER2b_XSP2Liver317733esr2bQ5PR29Gain100.00 μM
ATG_hERa_XSP2Liver2099ESR1P03372Gain65.91 μM
ATG_hPPARg_XSP2Liver5468PPARGP37231Gain139.97 μM
ATG_mPXR_XSP2Liver8856NR1I2O75469Gain19.63 μM
TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881Breast367ARP10275Loss26.66 μM
TOX21_CAR_LUC_AgonistLiver9970NR1I3Q14994Gain81.53 μM
TOX21_ERR_LUC_AntagonistKidney2101ESRRAP11474Loss73.20 μM
TOX21_PR_BLA_Antagonist_ratioKidney5241PGRP06401Loss48.15 μM
TOX21_PXR_LUC_AgonistLiver8856NR1I2O75469Gain54.54 μM
TOX21_p450_CYP2C19_Antagonist1557CYP2C19P33261Loss34.21 μM
TOX21_p450_CYP1A2_Antagonist1544CYP1A2P05177Loss0.69 μM

No ToxCast endpoints for intended target type: Molecular Messengers

ToxCast Endpoints for intended target type: Pathway
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
APR_HepG2_P-H2AX_72hrLiver3014H2AFXP16104Activatory104.00 μM
OT_ER_ERaERb_1440Kidney2100|2099ESR2|ESR1Q92731|P03372Gain31.93 μM
OT_ER_ERbERb_1440Kidney2100ESR2Q92731Gain32.87 μM
ACEA_AR_antagonist_80hrProstate367ARP10275Loss25.50 μM

ToxCast Endpoints for intended target type: Cellular
Assay NameTissueResponseAC50 value
APR_HepG2_MitoMembPot_24hrLiverInhibitory92.14 μM
APR_HepG2_NuclearSize_72hrLiverInhibitory113.03 μM
BSK_hDFCGF_ProliferationSkinInhibitory15.04 μM
ACEA_AR_antagonist_AUC_viabilityProstateLoss21.35 μM
TOX21_MMP_fitcLiverGain51.92 μM
TOX21_RXR_BLA_Agonist_viabilityKidneyLoss47.78 μM
TOX21_MMP_ratioLiverInhibitory53.21 μM
TOX21_ERb_BLA_Agonist_viabilityKidneyLoss47.93 μM

ToxCast Endpoints for intended target type: Extracellular
Assay NameTissueResponseAC50 value
TAMU_PeakParms_SingleDonor1434_ChronotropyHeartInhibitory50.00 μM
DISCLAIMER

TICToK is a knowledgebase of chemicals found in tattoo inks, compiled from publicly available regulatory and scientific resources. The chemical classifications presented in this knowledgebase are derived from multiple publicly available resources and are provided solely for informational purposes, and they are neither authoritative nor binding. The chemical-AOP mappings compiled in this knowledgebase serve as plausible hypotheses for research, and further experimental validation is required to definitively establish these potential toxicity mechanisms. The authors bear no responsibility for any errors, omissions, or inconsistencies originating from these external sources. Users are advised to exercise independent judgment when interpreting chemical classifications and any other data provided in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.