TICToK | Tattoo Ink Chemicals and assocaited Toxicities Knowledgebase

Dibenzofuran

Dibenzofuran

ToxCast Endpoints

For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the DOWNLOAD page.

ToxCast Endpoints for intended target type: RNA

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
LTEA_HepaRG_CYP1A1	Liver	1543	CYP1A1	P04798	Activatory	50.00 μM
LTEA_HepaRG_CYP1A2	Liver	1544	CYP1A2	P05177	Activatory	50.00 μM
LTEA_HepaRG_CYP2B6	Liver	1555	CYP2B6	P20813	Inhibitory	0.07 μM

ToxCast Endpoints for intended target type: Protein

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
CCTE_Deisenroth_AIME_384WELL_LUC_Active	Mammary Gland/Breast	2099	ESR1	P03372	Gain	75.93 μM
CCTE_Deisenroth_AIME_384WELL_LUC_Shift	Mammary Gland/Breast	2099	ESR1	P03372	Activatory	77.48 μM
TOX21_p450_CYP2C9_Antagonist		1559	CYP2C9	P11712	Loss	82.02 μM
TOX21_p450_CYP1A2_Antagonist		1544	CYP1A2	P05177	Loss	58.18 μM
TOX21_hERG_U2OS_Antagonist	Bone	3757	KCNH2	Q12809	Loss	48.14 μM
TOX21_p450_CYP1A2_Antagonist		1544	CYP1A2	P05177	Loss	27.07 μM

No ToxCast endpoints for intended target type: Molecular Messengers

ToxCast Endpoints for intended target type: Pathway

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
APR_HepG2_MitoticArrest_72hr	Liver	3020	H3F3A	P84243	Activatory	0.09 μM

ToxCast Endpoints for intended target type: Cellular

Assay Name	Tissue	Response	AC50 value
TOX21_RT_HEPG2_FLO_40hr_viability	Liver	Gain	24.25 μM
TOX21_RT_HEK293_FLO_40hr_viability	Kidney	Gain	59.18 μM

No ToxCast endpoints for intended target type: Extracellular

DISCLAIMER

TICToK is a database of tattoo ink chemicals compiled from different regulatory resources. The authors are not liable for any inaccuracies or omissions of any chemicals in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.