TICToK | Tattoo Ink Chemicals and associated Toxicities Knowledgebase

Fluoranthene

Fluoranthene

ToxCast Endpoints

For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the DOWNLOAD page.

ToxCast Endpoints for intended target type: RNA

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
LTEA_HepaRG_CYP2B6	Liver	1555	CYP2B6	P20813	Activatory	5.03 μM
LTEA_HepaRG_CYP2C19	Liver	1557	CYP2C19	P33261	Activatory	9.15 μM
LTEA_HepaRG_CYP3A7	Liver	1551	CYP3A7	P24462	Activatory	9.36 μM

ToxCast Endpoints for intended target type: Protein

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
NVS_ADME_hCYP1A2		1544	CYP1A2	P05177	Loss	7.21 μM
NVS_ENZ_hBACE		23621	BACE1	P56817	Loss	1.18 μM
NVS_ENZ_hMMP3		4314	MMP3	P08254	Loss	5.24 μM
ATG_M_19_CIS	Liver				Inhibitory	0.01 μM
ATG_M_32_CIS	Liver				Inhibitory	0.01 μM
ATG_NURR1_TRANS	Liver	4929	NR4A2	P43354	Gain	159.91 μM
BSK_3C_TissueFactor	Vascular	2152	F3	P13726	Inhibitory	0.67 μM
BSK_LPS_TNFa	Vascular	7124	TNF	P01375	Activatory	4.36 μM
ATG_mPXR_XSP2	Liver	8856	NR1I2	O75469	Gain	7.91 μM
TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881	Breast	367	AR	P10275	Loss	5.26 μM
TOX21_p450_CYP2D6_Antagonist		1565	CYP2D6	P10635	Loss	0.00 μM
TOX21_p450_CYP1A2_Antagonist		1544	CYP1A2	P05177	Loss	0.72 μM
TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881	Breast	367	AR	P10275	Loss	5.59 μM
TOX21_p450_CYP1A2_Antagonist		1544	CYP1A2	P05177	Loss	0.87 μM

No ToxCast endpoints for intended target type: Molecular Messengers

ToxCast Endpoints for intended target type: Pathway

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
APR_HepG2_CellCycleArrest_72hr	Liver				Inhibitory	110.93 μM

ToxCast Endpoints for intended target type: Cellular

Assay Name	Tissue	Response	AC50 value
ACEA_AR_antagonist_AUC_viability	Prostate	Loss	8.92 μM

No ToxCast endpoints for intended target type: Extracellular

DISCLAIMER

TICToK is a database of tattoo ink chemicals compiled from different regulatory resources. The authors are not liable for any inaccuracies or omissions of any chemicals in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.