For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the
DOWNLOAD page.
No ToxCast endpoints for intended target type: RNA
ToxCast Endpoints for intended target type: Protein
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
TOX21_ERa_LUC_VM7_Agonist | Breast | 2099 | ESR1 | P03372 | Gain | 7.38 μM |
TOX21_ERR_LUC_Agonist | Kidney | 2101 | ESRRA | P11474 | Gain | 2.83 μM |
TOX21_p450_CYP2C19_Antagonist | | 1557 | CYP2C19 | P33261 | Loss | 16.60 μM |
TOX21_p450_CYP1A2_Antagonist | | 1544 | CYP1A2 | P05177 | Loss | 3.69 μM |
No ToxCast endpoints for intended target type: Molecular Messengers
No ToxCast endpoints for intended target type: Pathway
ToxCast Endpoints for intended target type: Cellular
Assay Name | Tissue | Response | AC50 value |
---|
TOX21_MMP_rhodamine | Liver | Loss | 16.16 μM |
TOX21_MMP_ratio | Liver | Inhibitory | 12.68 μM |
No ToxCast endpoints for intended target type: Extracellular