Dibenz[a,h]anthracene

Dibenz[a,h]anthracene



ToxCast Endpoints
For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the DOWNLOAD page.

No ToxCast endpoints for intended target type: RNA

ToxCast Endpoints for intended target type: Protein
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
ATG_Ahr_CISLiver196AHRP35869Activatory0.02 μM
ATG_ERE_CISLiver2099ESR1P03372Activatory0.18 μM
ATG_FoxA2_CISLiver3170FOXA2Q9Y261Activatory0.08 μM
ATG_NRF2_ARE_CISLiver4780NFE2L2Q16236Activatory0.12 μM
BSK_3C_TissueFactorVascular2152F3P13726Activatory0.04 μM
BSK_4H_Eotaxin3Vascular10344CCL26Q9Y258Inhibitory0.04 μM
BSK_BE3C_MMP1Lung4312MMP1P03956Activatory0.02 μM
BSK_hDFCGF_VCAM1Skin7412VCAM1P19320Inhibitory0.02 μM
BSK_KF3CT_TIMP2Skin7077TIMP2Q96MC4Inhibitory3.59 μM
BSK_LPS_TissueFactorVascular2152F3P13726Activatory0.03 μM
BSK_BT_xIL2Vascular3558IL2Inhibitory0.04 μM
BSK_BT_xIL6Vascular3569IL6P05231Inhibitory0.02 μM
BSK_3C_TissueFactorVascular2152F3P13726Activatory0.02 μM
BSK_4H_Eotaxin3Vascular10344CCL26Q9Y258Inhibitory0.02 μM
BSK_BE3C_MMP1Lung4312MMP1P03956Activatory0.02 μM
BSK_CASM3C_ThrombomodulinVascular7056THBDP07204Activatory0.10 μM
BSK_BT_xIL6Vascular3569IL6P05231Inhibitory3.57 μM
NVS_ENZ_hBACE23621BACE1P56817Loss12.98 μM
NVS_ENZ_hCASP5838CASP5P51878Loss5.15 μM
NVS_ENZ_hMMP94318MMP9P14780Loss4.46 μM
TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2Breast2099ESR1P03372Loss0.12 μM
TOX21_AhR_LUC_AgonistLiver196AHRP35869Gain0.10 μM
TOX21_CAR_LUC_AntagonistLiver9970NR1I3Q14994Loss0.04 μM
TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2Breast2099ESR1P03372Loss0.13 μM
TOX21_p450_CYP1A2_Antagonist1544CYP1A2P05177Loss11.60 μM
TOX21_AhR_LUC_AgonistLiver196AHRP35869Gain0.06 μM
TOX21_CAR_LUC_AgonistLiver9970NR1I3Q14994Gain7.59 μM
TOX21_CAR_LUC_AntagonistLiver9970NR1I3Q14994Loss0.13 μM
TOX21_p450_CYP1A2_Antagonist1544CYP1A2P05177Loss19.58 μM

No ToxCast endpoints for intended target type: Molecular Messengers

ToxCast Endpoints for intended target type: Pathway
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
TOX21_AR_BLA_Agonist_ch2KidneyGain5.67 μM
TOX21_ARE_BLA_Agonist_ch2LiverGain2.65 μM
TOX21_p53_BLA_p3_ch2IntestinalGain21.47 μM
TOX21_ESRE_BLA_Agonist_ch2CervixGain5.11 μM
TOX21_ESRE_BLA_Agonist_ratioCervix22926ATF6P18850Gain19.39 μM
TOX21_AP1_BLA_Agonist_ch2CervixGain31.07 μM
TOX21_HDAC_LUC_AntagonistColon3065HDAC1Q13547Loss6.51 μM
TOX21_p53_BLA_p3_ch2IntestinalGain18.23 μM
TOX21_ESRE_BLA_Agonist_ch2CervixGain5.85 μM
TOX21_HDAC_LUC_AntagonistColon3065HDAC1Q13547Loss7.29 μM

ToxCast Endpoints for intended target type: Cellular
Assay NameTissueResponseAC50 value
BSK_3C_VisVascularInhibitory35.68 μM
TOX21_RT_HEPG2_FLO_40hr_viabilityLiverGain4.57 μM

ToxCast Endpoints for intended target type: Extracellular
Assay NameTissueResponseAC50 value
TAMU_PeakParms_SingleDonor1434_ChronotropyHeartInhibitory50.00 μM
DISCLAIMER

TICToK is a database of tattoo ink chemicals compiled from different regulatory resources. The authors are not liable for any inaccuracies or omissions of any chemicals in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.