For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the
DOWNLOAD page.
ToxCast Endpoints for intended target type: RNA
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
LTEA_HepaRG_CYP2B6 | Liver | 1555 | CYP2B6 | P20813 | Activatory | 22.62 μM |
LTEA_HepaRG_NFKB1 | Liver | 4790 | NFKB1 | P19838 | Inhibitory | 1.06 μM |
ToxCast Endpoints for intended target type: Protein
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
CCTE_Deisenroth_AIME_384WELL_LUC_Active | Mammary Gland/Breast | 2099 | ESR1 | P03372 | Gain | 0.00 μM |
CCTE_Deisenroth_AIME_384WELL_LUC_Inactive | Mammary Gland/Breast | 2099 | ESR1 | P03372 | Gain | 0.00 μM |
CCTE_Deisenroth_AIME_384WELL_LUC_Shift | Mammary Gland/Breast | 2099 | ESR1 | P03372 | Inhibitory | 0.00 μM |
NVS_LGIC_h5HT3 | | 3359 | HTR3A | P46098 | Loss | 25.00 μM |
NVS_NR_hPPARg | | 5468 | PPARG | P37231 | Loss | 0.00 μM |
TOX21_p450_CYP1A2_Antagonist | | 1544 | CYP1A2 | P05177 | Loss | 37.81 μM |
No ToxCast endpoints for intended target type: Molecular Messengers
ToxCast Endpoints for intended target type: Pathway
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
APR_HepG2_p53Act_24hr | Liver | 7157 | TP53 | P04637 | Activatory | 0.04 μM |
No ToxCast endpoints for intended target type: Cellular
No ToxCast endpoints for intended target type: Extracellular