For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the
DOWNLOAD page.
ToxCast Endpoints for intended target type: RNA
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
LTEA_HepaRG_CYP1A1 | Liver | 1543 | CYP1A1 | P04798 | Activatory | 76.62 μM |
LTEA_HepaRG_CYP1A2 | Liver | 1544 | CYP1A2 | P05177 | Activatory | 50.00 μM |
LTEA_HepaRG_CYP2B6 | Liver | 1555 | CYP2B6 | P20813 | Inhibitory | 0.10 μM |
ToxCast Endpoints for intended target type: Protein
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
TOX21_p450_CYP2D6_Antagonist | | 1565 | CYP2D6 | P10635 | Loss | 107.98 μM |
No ToxCast endpoints for intended target type: Molecular Messengers
No ToxCast endpoints for intended target type: Pathway
ToxCast Endpoints for intended target type: Cellular
Assay Name | Tissue | Response | AC50 value |
---|
APR_HepG2_CellLoss_72hr | Liver | Inhibitory | 61.44 μM |
No ToxCast endpoints for intended target type: Extracellular