For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the
DOWNLOAD page.
No ToxCast endpoints for intended target type: RNA
ToxCast Endpoints for intended target type: Protein
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
ATG_Ahr_CIS | Liver | 196 | AHR | P35869 | Activatory | 6.44 μM |
NVS_MP_hPBR | Intestinal | 706 | TSPO | P30536 | Loss | 0.54 μM |
TOX21_p450_CYP2D6_Antagonist | | 1565 | CYP2D6 | P10635 | Loss | 0.00 μM |
TOX21_p450_CYP2C19_Antagonist | | 1557 | CYP2C19 | P33261 | Loss | 0.00 μM |
No ToxCast endpoints for intended target type: Molecular Messengers
ToxCast Endpoints for intended target type: Pathway
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
TOX21_ARE_BLA_Agonist_ch1 | Liver | | | | Loss | 8.33 μM |
TOX21_ARE_BLA_Agonist_ch2 | Liver | | | | Gain | 5.30 μM |
TOX21_ARE_BLA_Agonist_ratio | Liver | 4780 | NFE2L2 | Q16236 | Gain | 8.22 μM |
TOX21_HDAC_LUC_Antagonist | Colon | 3065 | HDAC1 | Q13547 | Loss | 2.07 μM |
ToxCast Endpoints for intended target type: Cellular
Assay Name | Tissue | Response | AC50 value |
---|
ACEA_AR_antagonist_AUC_viability | Prostate | Loss | 0.62 μM |
No ToxCast endpoints for intended target type: Extracellular