For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the
DOWNLOAD page.
ToxCast Endpoints for intended target type: RNA
| Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
|---|
| LTEA_HepaRG_ABCB1 | Liver | 5243 | ABCB1 | P08183 | Activatory | 0.07 μM |
| LTEA_HepaRG_ABCB11 | Liver | 8647 | ABCB11 | O95342 | Inhibitory | 3.77 μM |
| LTEA_HepaRG_CYP1A1 | Liver | 1543 | CYP1A1 | P04798 | Activatory | 50.00 μM |
| LTEA_HepaRG_CYP2B6 | Liver | 1555 | CYP2B6 | P20813 | Activatory | 50.00 μM |
| LTEA_HepaRG_CYP2E1 | Liver | 1571 | CYP2E1 | P05181 | Inhibitory | 12.29 μM |
| LTEA_HepaRG_CYP4A11 | Liver | 1579 | CYP4A11 | Q02928 | Inhibitory | 33.10 μM |
| LTEA_HepaRG_CYP4A22 | Liver | 284541 | CYP4A22 | Q5TCH4 | Inhibitory | 8.30 μM |
| LTEA_HepaRG_CYP7A1 | Liver | 1581 | CYP7A1 | P22680 | Inhibitory | 1.44 μM |
| LTEA_HepaRG_PEG10 | Liver | 23089 | PEG10 | Q86TG7 | Inhibitory | 2.20 μM |
ToxCast Endpoints for intended target type: Protein
| Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
|---|
| NVS_ADME_hCYP1A1 | | 1543 | CYP1A1 | P04798 | Loss | 3.10 μM |
| NVS_ADME_hCYP2C19 | | 1557 | CYP2C19 | P33261 | Loss | 8.09 μM |
| NVS_ADME_hCYP2C9 | | 1559 | CYP2C9 | P11712 | Loss | 10.00 μM |
| NVS_TR_hNET | | 6530 | SLC6A2 | P23975 | Loss | 11.83 μM |
| ATG_ERE_CIS | Liver | 2099 | ESR1 | P03372 | Activatory | 33.20 μM |
| ATG_ERa_TRANS | Liver | 2099 | ESR1 | P03372 | Gain | 38.03 μM |
| ATG_RXRb_TRANS | Liver | 6257 | RXRB | P28702 | Gain | 27.51 μM |
| BSK_3C_TissueFactor | Vascular | 2152 | F3 | P13726 | Inhibitory | 3.97 μM |
| BSK_BE3C_tPA | Lung | 5327 | PLAT | P00750 | Inhibitory | 6.73 μM |
| BSK_LPS_PGE2 | Vascular | 5732 | PTGER2 | P43116 | Inhibitory | 8.27 μM |
| TOX21_AhR_LUC_Agonist | Liver | 196 | AHR | P35869 | Gain | 15.11 μM |
| TOX21_CAR_LUC_Agonist | Liver | 9970 | NR1I3 | Q14994 | Gain | 36.63 μM |
| TOX21_PXR_LUC_Agonist | Liver | 8856 | NR1I2 | O75469 | Gain | 22.62 μM |
| TOX21_p450_CYP3A4_Antagonist | | 1576 | CYP3A4 | P08684 | Loss | 16.69 μM |
| TOX21_p450_CYP2D6_Antagonist | | 1565 | CYP2D6 | P10635 | Loss | 56.93 μM |
| TOX21_p450_CYP2C19_Antagonist | | 1557 | CYP2C19 | P33261 | Loss | 25.70 μM |
| TOX21_p450_CYP2C9_Antagonist | | 1559 | CYP2C9 | P11712 | Loss | 33.68 μM |
| TOX21_p450_CYP1A2_Antagonist | | 1544 | CYP1A2 | P05177 | Loss | 14.89 μM |
| TOX21_ERa_LUC_VM7_Agonist | Breast | 2099 | ESR1 | P03372 | Gain | 7.46 μM |
| TOX21_AhR_LUC_Agonist | Liver | 196 | AHR | P35869 | Gain | 32.38 μM |
| TOX21_CAR_LUC_Agonist | Liver | 9970 | NR1I3 | Q14994 | Gain | 18.05 μM |
| TOX21_PXR_LUC_Agonist | Liver | 8856 | NR1I2 | O75469 | Gain | 35.63 μM |
| TOX21_p450_CYP3A4_Antagonist | | 1576 | CYP3A4 | P08684 | Loss | 15.91 μM |
| TOX21_p450_CYP2C19_Antagonist | | 1557 | CYP2C19 | P33261 | Loss | 28.91 μM |
| TOX21_p450_CYP2C9_Antagonist | | 1559 | CYP2C9 | P11712 | Loss | 22.84 μM |
| TOX21_p450_CYP1A2_Antagonist | | 1544 | CYP1A2 | P05177 | Loss | 21.40 μM |
No ToxCast endpoints for intended target type: Molecular Messengers
ToxCast Endpoints for intended target type: Pathway
| Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
|---|
| APR_HepG2_CellCycleArrest_24hr | Liver | | | | Inhibitory | 100.00 μM |
| APR_HepG2_P-H2AX_24hr | Liver | 3014 | H2AFX | P16104 | Activatory | 91.24 μM |
| APR_HepG2_p53Act_24hr | Liver | 7157 | TP53 | P04637 | Activatory | 100.00 μM |
| APR_HepG2_P-H2AX_72hr | Liver | 3014 | H2AFX | P16104 | Activatory | 103.78 μM |
| APR_HepG2_p53Act_72hr | Liver | 7157 | TP53 | P04637 | Activatory | 105.73 μM |
| OT_FXR_FXRSRC1_1440 | Kidney | 6714|9971 | NR1H4|SRC | P12931|Q96RI1 | Gain | 50.00 μM |
| ACEA_AR_antagonist_80hr | Prostate | 367 | AR | P10275 | Loss | 39.70 μM |
| TOX21_ARE_BLA_Agonist_ratio | Liver | 4780 | NFE2L2 | Q16236 | Gain | 40.14 μM |
| TOX21_TSHR_HTRF_Antagonist_ch2 | Kidney | | | | Loss | 35.91 μM |
| TOX21_HDAC_LUC_Antagonist | Colon | 3065 | HDAC1 | Q13547 | Loss | 45.65 μM |
| TOX21_TSHR_HTRF_Antagonist_ch2 | Kidney | | | | Loss | 36.58 μM |
ToxCast Endpoints for intended target type: Cellular
| Assay Name | Tissue | Response | AC50 value |
|---|
| TOX21_RT_HEPG2_FLO_40hr_viability | Liver | Gain | 61.32 μM |
No ToxCast endpoints for intended target type: Extracellular
