For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the
DOWNLOAD page.
ToxCast Endpoints for intended target type: RNA
| Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
|---|
| LTEA_HepaRG_TNFRSF1A | Liver | 7132 | TNFRSF1A | P19438 | Inhibitory | 0.78 μM |
ToxCast Endpoints for intended target type: Protein
| Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
|---|
| ATG_ERE_CIS | Liver | 2099 | ESR1 | P03372 | Activatory | 16.01 μM |
| ATG_PXRE_CIS | Liver | 8856 | NR1I2 | O75469 | Activatory | 60.00 μM |
| ATG_ERa_TRANS | Liver | 2099 | ESR1 | P03372 | Gain | 20.80 μM |
| CCTE_GLTED_hTTR_0.125uM | | 7276 | TTR | | Loss | 5.01 μM |
| ERF_TW_NR_binding_hERa | | 2099 | ESR1 | P03372 | Gain | 1.30 μM |
| ATG_AP_1_CIS | Liver | 3725|2353 | JUN|FOS | P01100|P05412 | Activatory | 48.18 μM |
| ATG_BRE_CIS | Liver | 4086 | SMAD1 | Q15797 | Activatory | 79.26 μM |
| ATG_CMV_CIS | Liver | | | | Activatory | 120.58 μM |
| ATG_CRE_CIS | Liver | 10488 | CREB3 | O43889 | Activatory | 170.91 μM |
| ATG_DR4_LXR_CIS | Liver | 7376|10062 | NR1H2|NR1H3 | P55055|Q13133 | Activatory | 26.15 μM |
| ATG_DR5_RAR_CIS | Liver | 5916|5915|5914 | RARG|RARB|RARA | P10826|P10276|P13631 | Inhibitory | 25.21 μM |
| ATG_EGR_CIS | Liver | 1958 | EGR1 | P18146 | Activatory | 157.29 μM |
| ATG_ERE_CIS | Liver | 2099 | ESR1 | P03372 | Activatory | 6.06 μM |
| ATG_HIF1a_CIS | Liver | 3091 | HIF1A | Q16665 | Inhibitory | 175.75 μM |
| ATG_MRE_CIS | Liver | 4520 | MTF1 | Q14872 | Activatory | 100.00 μM |
| ATG_NRF2_ARE_CIS | Liver | 4780 | NFE2L2 | Q16236 | Activatory | 77.67 μM |
| ATG_Oct_MLP_CIS | Liver | 5451 | POU2F1 | P14859 | Activatory | 167.70 μM |
| ATG_Pax6_CIS | Liver | 5080 | PAX6 | P26367 | Activatory | 142.24 μM |
| ATG_PPRE_CIS | Liver | 5468|5467|5465 | PPARG|PPARD|PPARA | P37231|Q07869|Q03181 | Activatory | 77.53 μM |
| ATG_PXRE_CIS | Liver | 8856 | NR1I2 | O75469 | Activatory | 34.21 μM |
| ATG_RORE_CIS | Liver | 6096|6095|6097 | RORB|RORA|RORC | P51449|Q92753|P35398 | Activatory | 127.81 μM |
| ATG_SREBP_CIS | Liver | 6720 | SREBF1 | P36956 | Activatory | 26.44 μM |
| ATG_TA_CIS | Liver | | | | Activatory | 161.96 μM |
| ATG_VDRE_CIS | Liver | 7421 | VDR | P11473 | Activatory | 138.55 μM |
| ATG_Xbp1_CIS | Liver | 7494 | XBP1 | P17861 | Activatory | 73.51 μM |
| ATG_ERa_TRANS | Liver | 2099 | ESR1 | P03372 | Gain | 6.31 μM |
| ATG_PPARg_TRANS | Liver | 5468 | PPARG | P37231 | Gain | 45.61 μM |
| ATG_PXR_TRANS | Liver | 8856 | NR1I2 | O75469 | Gain | 100.00 μM |
| NVS_ADME_hCYP1A2 | | 1544 | CYP1A2 | P05177 | Loss | 6.46 μM |
| NVS_GPCR_hAdoRA1 | Brain | 134 | ADORA1 | P30542 | Loss | 11.80 μM |
| NVS_NR_hER | | 2099 | ESR1 | P03372 | Loss | 10.65 μM |
| NVS_TR_hDAT | | 6531 | SLC6A3 | Q01959 | Loss | 15.34 μM |
| NVS_TR_hNET | | 6530 | SLC6A2 | P23975 | Loss | 9.32 μM |
| BSK_LPS_PGE2 | Vascular | 5732 | PTGER2 | P43116 | Inhibitory | 9.70 μM |
| NVS_NR_hER | | 2099 | ESR1 | P03372 | Loss | 6.72 μM |
| ATG_trERa_XSP2 | Liver | 101933533 | ESR1 | B6E1V9 | Gain | 0.73 μM |
| ATG_hERb_XSP2 | Liver | 2100 | ESR2 | Q92731 | Gain | 2.52 μM |
| ATG_zfER1_XSP2 | Liver | 259252 | esr1 | P57717 | Gain | 11.12 μM |
| ATG_chERa_XSP2 | Liver | 396099 | ESR1 | P06212 | Gain | 9.35 μM |
| ATG_zfER2a_XSP2 | Liver | 317734 | esr2a | Q7ZU32 | Gain | 3.49 μM |
| ATG_chAR_XSP2 | Liver | 422165 | AR | Q2ACE0 | Gain | 32.01 μM |
| ATG_frER1_XSP2 | Liver | 398734 | esr1.L | Q6W5G7 | Gain | 0.41 μM |
| ATG_zfER2b_XSP2 | Liver | 317733 | esr2b | Q5PR29 | Gain | 8.51 μM |
| ATG_hERa_XSP2 | Liver | 2099 | ESR1 | P03372 | Gain | 2.61 μM |
| ATG_frER2_XSP2 | Liver | 100174814 | esr2.L | A0A1L8FA50 | Gain | 1.53 μM |
| ATG_mPPARg_XSP2 | Liver | 19016 | Pparg | P37238 | Gain | 87.64 μM |
| ATG_hPPARg_XSP2 | Liver | 5468 | PPARG | P37231 | Gain | 100.00 μM |
| ATG_trERa_XSP2 | Liver | 101933533 | ESR1 | B6E1V9 | Gain | 72.86 μM |
| ATG_hERb_XSP2 | Liver | 2100 | ESR2 | Q92731 | Gain | 31.89 μM |
| ATG_chERa_XSP2 | Liver | 396099 | ESR1 | P06212 | Gain | 27.79 μM |
| ATG_zfER2a_XSP2 | Liver | 317734 | esr2a | Q7ZU32 | Gain | 51.03 μM |
| ATG_frER1_XSP2 | Liver | 398734 | esr1.L | Q6W5G7 | Gain | 27.73 μM |
| ATG_zfER2b_XSP2 | Liver | 317733 | esr2b | Q5PR29 | Gain | 65.81 μM |
| ATG_hERa_XSP2 | Liver | 2099 | ESR1 | P03372 | Gain | 23.53 μM |
| ATG_frER2_XSP2 | Liver | 100174814 | esr2.L | A0A1L8FA50 | Gain | 38.25 μM |
| ATG_mPPARg_XSP2 | Liver | 19016 | Pparg | P37238 | Gain | 100.00 μM |
| ATG_hPPARg_XSP2 | Liver | 5468 | PPARG | P37231 | Gain | 66.41 μM |
| ATG_hTRb_XSP2 | Liver | 7068 | THRB | P10828 | Gain | 100.00 μM |
| TOX21_ERa_LUC_VM7_Agonist | Breast | 2099 | ESR1 | P03372 | Gain | 17.82 μM |
| TOX21_ERa_BLA_Agonist_ratio | Kidney | 2099 | ESR1 | P03372 | Gain | 58.97 μM |
| TOX21_ERa_LUC_VM7_Agonist | Breast | 2099 | ESR1 | P03372 | Gain | 16.47 μM |
| TOX21_CAR_LUC_Agonist | Liver | 9970 | NR1I3 | Q14994 | Gain | 80.87 μM |
| TOX21_ERb_BLA_Antagonist_ratio | Kidney | 2100 | ESR2 | Q92731 | Loss | 39.63 μM |
| TOX21_PR_BLA_Antagonist_ratio | Kidney | 5241 | PGR | P06401 | Loss | 49.37 μM |
| TOX21_ERa_LUC_VM7_Agonist_10nM_ICI182780 | Breast | 2099 | ESR1 | P03372 | Gain | 55.03 μM |
| TOX21_PXR_LUC_Agonist | Liver | 8856 | NR1I2 | O75469 | Gain | 68.05 μM |
| TOX21_p450_CYP2D6_Antagonist | | 1565 | CYP2D6 | P10635 | Loss | 105.94 μM |
| TOX21_p450_CYP2C19_Antagonist | | 1557 | CYP2C19 | P33261 | Loss | 31.57 μM |
| TOX21_p450_CYP1A2_Antagonist | | 1544 | CYP1A2 | P05177 | Loss | 9.58 μM |
No ToxCast endpoints for intended target type: Molecular Messengers
ToxCast Endpoints for intended target type: Pathway
| Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
|---|
| ACEA_ER_80hr | Breast | 2099 | ESR1 | P03372 | Gain | 2.70 μM |
| OT_ER_ERaERa_0480 | Kidney | 2099 | ESR1 | P03372 | Gain | 38.44 μM |
| OT_ER_ERaERa_1440 | Kidney | 2099 | ESR1 | P03372 | Gain | 31.19 μM |
| OT_ER_ERaERb_0480 | Kidney | 2100|2099 | ESR2|ESR1 | Q92731|P03372 | Gain | 16.68 μM |
| OT_ER_ERaERb_1440 | Kidney | 2100|2099 | ESR2|ESR1 | Q92731|P03372 | Gain | 15.51 μM |
| OT_ER_ERbERb_0480 | Kidney | 2100 | ESR2 | Q92731 | Gain | 7.31 μM |
| OT_ER_ERbERb_1440 | Kidney | 2100 | ESR2 | Q92731 | Gain | 8.13 μM |
| OT_ERa_GFPERaERE_0480 | Cervix | 2099 | ESR1 | P03372 | Gain | 27.58 μM |
| OT_FXR_FXRSRC1_1440 | Kidney | 6714|9971 | NR1H4|SRC | P12931|Q96RI1 | Gain | 58.52 μM |
| ACEA_AR_antagonist_80hr | Prostate | 367 | AR | P10275 | Loss | 50.00 μM |
| TOX21_ERa_BLA_Agonist_ch2 | Kidney | | | | Gain | 31.99 μM |
| TOX21_ERa_BLA_Agonist_ch2 | Kidney | | | | Gain | 56.49 μM |
| TOX21_HDAC_LUC_Antagonist | Colon | 3065 | HDAC1 | Q13547 | Loss | 51.16 μM |
| TOX21_ERb_BLA_Agonist_ch2 | Kidney | | | | Gain | 20.25 μM |
ToxCast Endpoints for intended target type: Cellular
| Assay Name | Tissue | Response | AC50 value |
|---|
| CCTE_Simmons_MITO_basal_resp_rate | Liver | Activatory | 35.75 μM |
| TOX21_MMP_ratio | Liver | Inhibitory | 23.04 μM |
| TOX21_MMP_fitc | Liver | Gain | 56.41 μM |
| TOX21_MMP_rhodamine | Liver | Loss | 53.87 μM |
| TOX21_MMP_ratio | Liver | Inhibitory | 68.64 μM |
| TOX21_RT_HEK293_GLO_24hr_viability | Kidney | Loss | 38.32 μM |
| TOX21_RT_HEK293_GLO_40hr_viability | Kidney | Loss | 46.03 μM |
No ToxCast endpoints for intended target type: Extracellular
