For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the
DOWNLOAD page.
ToxCast Endpoints for intended target type: RNA
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
LTEA_HepaRG_CYP1A1 | Liver | 1543 | CYP1A1 | P04798 | Activatory | 24.97 μM |
LTEA_HepaRG_CYP1A2 | Liver | 1544 | CYP1A2 | P05177 | Activatory | 26.78 μM |
LTEA_HepaRG_CYP2B6 | Liver | 1555 | CYP2B6 | P20813 | Activatory | 18.36 μM |
LTEA_HepaRG_CYP2E1 | Liver | 1571 | CYP2E1 | P05181 | Inhibitory | 32.40 μM |
LTEA_HepaRG_THRSP | Liver | 7069 | THRSP | Q92748 | Inhibitory | 13.29 μM |
LTEA_HepaRG_UGT1A1 | Liver | 54658 | UGT1A1 | P22309 | Activatory | 50.00 μM |
ToxCast Endpoints for intended target type: Protein
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
CCTE_GLTED_hTBG | | 6906 | SERPINA7 | | Loss | 50.00 μM |
NVS_ADME_hCYP2A6 | | 1548 | CYP2A6 | P11509 | Loss | 10.00 μM |
NVS_ADME_hCYP2B6 | | 1555 | CYP2B6 | P20813 | Loss | 2.51 μM |
NVS_ADME_hCYP2C19 | | 1557 | CYP2C19 | P33261 | Loss | 4.92 μM |
ATG_Ahr_CIS | Liver | 196 | AHR | P35869 | Activatory | 1.51 μM |
ATG_PXRE_CIS | Liver | 8856 | NR1I2 | O75469 | Activatory | 45.42 μM |
ATG_RORg_TRANS | Liver | 6097 | RORC | P51449 | Gain | 25.68 μM |
BSK_SAg_Eselectin | Vascular | 6401 | SELE | P16581 | Activatory | 5.91 μM |
TOX21_AhR_LUC_Agonist | Liver | 196 | AHR | P35869 | Gain | 62.51 μM |
TOX21_p450_CYP3A4_Antagonist | | 1576 | CYP3A4 | P08684 | Loss | 46.18 μM |
TOX21_p450_CYP2D6_Antagonist | | 1565 | CYP2D6 | P10635 | Loss | 54.25 μM |
TOX21_p450_CYP2C19_Antagonist | | 1557 | CYP2C19 | P33261 | Loss | 42.54 μM |
TOX21_p450_CYP2C9_Antagonist | | 1559 | CYP2C9 | P11712 | Loss | 46.74 μM |
TOX21_p450_CYP1A2_Antagonist | | 1544 | CYP1A2 | P05177 | Loss | 10.31 μM |
TOX21_AhR_LUC_Agonist | Liver | 196 | AHR | P35869 | Gain | 39.70 μM |
TOX21_PR_BLA_Antagonist_ratio | Kidney | 5241 | PGR | P06401 | Loss | 9.14 μM |
TOX21_p450_CYP3A4_Antagonist | | 1576 | CYP3A4 | P08684 | Loss | 67.80 μM |
TOX21_p450_CYP2D6_Antagonist | | 1565 | CYP2D6 | P10635 | Loss | 47.75 μM |
TOX21_p450_CYP2C19_Antagonist | | 1557 | CYP2C19 | P33261 | Loss | 33.81 μM |
TOX21_p450_CYP2C9_Antagonist | | 1559 | CYP2C9 | P11712 | Loss | 57.47 μM |
TOX21_p450_CYP1A2_Antagonist | | 1544 | CYP1A2 | P05177 | Loss | 12.44 μM |
No ToxCast endpoints for intended target type: Molecular Messengers
ToxCast Endpoints for intended target type: Pathway
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
ACEA_AR_antagonist_80hr | Prostate | 367 | AR | P10275 | Loss | 23.94 μM |
TOX21_RXR_BLA_Agonist_ch2 | Kidney | | | | Gain | 31.06 μM |
TOX21_RXR_BLA_Agonist_ratio | Kidney | 6256 | RXRA | P19793 | Gain | 26.60 μM |
No ToxCast endpoints for intended target type: Cellular
No ToxCast endpoints for intended target type: Extracellular