TICToK | Tattoo Ink Chemicals and associated Toxicities Knowledgebase

Methylparaben

Methylparaben

ToxCast Endpoints

For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the DOWNLOAD page.

No ToxCast endpoints for intended target type: RNA

ToxCast Endpoints for intended target type: Protein

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
ATG_ERE_CIS	Liver	2099	ESR1	P03372	Activatory	67.44 μM
ATG_ERa_TRANS	Liver	2099	ESR1	P03372	Gain	63.79 μM
ATG_RXRb_TRANS	Liver	6257	RXRB	P28702	Gain	55.32 μM
BSK_LPS_PGE2	Vascular	5732	PTGER2	P43116	Inhibitory	1.34 μM
STM_H9_OrnithineISnorm_perc					Inhibitory	0.09 μM
TOX21_p450_CYP1A2_Antagonist		1544	CYP1A2	P05177	Loss	24.78 μM
TOX21_AhR_LUC_Agonist	Liver	196	AHR	P35869	Gain	70.04 μM
TOX21_p450_CYP2D6_Antagonist		1565	CYP2D6	P10635	Loss	0.00 μM
TOX21_p450_CYP1A2_Antagonist		1544	CYP1A2	P05177	Loss	36.47 μM
TOX21_p450_CYP1A2_Antagonist		1544	CYP1A2	P05177	Loss	42.25 μM

No ToxCast endpoints for intended target type: Molecular Messengers

ToxCast Endpoints for intended target type: Pathway

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
OT_ER_ERaERb_0480	Kidney	2100\|2099	ESR2\|ESR1	Q92731\|P03372	Gain	50.00 μM
OT_ER_ERaERb_1440	Kidney	2100\|2099	ESR2\|ESR1	Q92731\|P03372	Gain	74.61 μM
OT_ER_ERbERb_0480	Kidney	2100	ESR2	Q92731	Gain	63.28 μM
ACEA_AR_antagonist_80hr	Prostate	367	AR	P10275	Loss	22.68 μM
TOX21_ARE_BLA_Agonist_ratio	Liver	4780	NFE2L2	Q16236	Gain	72.51 μM

ToxCast Endpoints for intended target type: Cellular

Assay Name	Tissue	Response	AC50 value
ArunA_NOG_NucleusCount	H9-Derived Embryonic Differentiated Neurons	Loss	13.67 μM
ArunA_NOG_NeuriteLength	H9-Derived Embryonic Differentiated Neurons	Loss	18.13 μM
ArunA_NOG_NeuritesPerNeuron	H9-Derived Embryonic Differentiated Neurons	Loss	17.41 μM
ArunA_NOG_BranchPointsPerNeurite	H9-Derived Embryonic Differentiated Neurons	Gain	14.81 μM
ACEA_AR_antagonist_AUC_viability	Prostate	Loss	12.70 μM

ToxCast Endpoints for intended target type: Extracellular

Assay Name	Tissue	Response	AC50 value
TAMU_PeakParms_SingleDonor1434_Chronotropy	Heart	Inhibitory	50.00 μM

DISCLAIMER

TICToK is a database of tattoo ink chemicals compiled from different regulatory resources. The authors are not liable for any inaccuracies or omissions of any chemicals in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.