For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the
DOWNLOAD page.
No ToxCast endpoints for intended target type: RNA
ToxCast Endpoints for intended target type: Protein
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
ATG_ERE_CIS | Liver | 2099 | ESR1 | P03372 | Activatory | 67.44 μM |
ATG_ERa_TRANS | Liver | 2099 | ESR1 | P03372 | Gain | 63.79 μM |
ATG_RXRb_TRANS | Liver | 6257 | RXRB | P28702 | Gain | 55.32 μM |
BSK_LPS_PGE2 | Vascular | 5732 | PTGER2 | P43116 | Inhibitory | 1.34 μM |
STM_H9_OrnithineISnorm_perc | | | | | Inhibitory | 0.09 μM |
TOX21_p450_CYP1A2_Antagonist | | 1544 | CYP1A2 | P05177 | Loss | 24.78 μM |
TOX21_AhR_LUC_Agonist | Liver | 196 | AHR | P35869 | Gain | 70.04 μM |
TOX21_p450_CYP2D6_Antagonist | | 1565 | CYP2D6 | P10635 | Loss | 0.00 μM |
TOX21_p450_CYP1A2_Antagonist | | 1544 | CYP1A2 | P05177 | Loss | 36.47 μM |
TOX21_p450_CYP1A2_Antagonist | | 1544 | CYP1A2 | P05177 | Loss | 42.25 μM |
No ToxCast endpoints for intended target type: Molecular Messengers
ToxCast Endpoints for intended target type: Pathway
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
OT_ER_ERaERb_0480 | Kidney | 2100|2099 | ESR2|ESR1 | Q92731|P03372 | Gain | 50.00 μM |
OT_ER_ERaERb_1440 | Kidney | 2100|2099 | ESR2|ESR1 | Q92731|P03372 | Gain | 74.61 μM |
OT_ER_ERbERb_0480 | Kidney | 2100 | ESR2 | Q92731 | Gain | 63.28 μM |
ACEA_AR_antagonist_80hr | Prostate | 367 | AR | P10275 | Loss | 22.68 μM |
TOX21_ARE_BLA_Agonist_ratio | Liver | 4780 | NFE2L2 | Q16236 | Gain | 72.51 μM |
ToxCast Endpoints for intended target type: Cellular
Assay Name | Tissue | Response | AC50 value |
---|
ArunA_NOG_NucleusCount | H9-Derived Embryonic Differentiated Neurons | Loss | 13.67 μM |
ArunA_NOG_NeuriteLength | H9-Derived Embryonic Differentiated Neurons | Loss | 18.13 μM |
ArunA_NOG_NeuritesPerNeuron | H9-Derived Embryonic Differentiated Neurons | Loss | 17.41 μM |
ArunA_NOG_BranchPointsPerNeurite | H9-Derived Embryonic Differentiated Neurons | Gain | 14.81 μM |
ACEA_AR_antagonist_AUC_viability | Prostate | Loss | 12.70 μM |
ToxCast Endpoints for intended target type: Extracellular
Assay Name | Tissue | Response | AC50 value |
---|
TAMU_PeakParms_SingleDonor1434_Chronotropy | Heart | Inhibitory | 50.00 μM |