Ultraviolet (UV) radiation is known to induce deleterious effects on the skin, with long-term exposure posing a significant risk of skin cancer and, in severe cases, mortality. The UltraViolet Radiation Expression Knowledgebase (UVREK) serves as a comprehensive repository detailing genes, proteins, metabolites, and miRNAs affected by UV exposure. This database is a product of meticulous manual curation, consolidating findings from published literature specifically focused on humans and rodents. The UVREK database is a invaluable resource compiling biomolecules associated with both early and late stages of UV exposure from published studies. This resource facilitates an understanding of the molecular responses to UV radiation and will aid in the development of targeted treatments tailored to the specific stages of exposure.
UVREK is a meticulously curated database housing comprehensive information on 985 genes (Gene Symbols), 470 proteins (Uniprot IDs), 54 metabolites (CAS IDs), and 77 miRNAs (Accessions) affected by UV exposure. All data entries have been mapped to standardized identifiers. Furthermore, metadata for each entry is provided, encompassing details such as the organism tested, exposure area, UV dose specifics, and the testing method employed.
UVREK stands as a comprehensive knowledgebase, encompassing biomolecules implicated in UV exposure across humans and rodents. The data within this repository has been meticulously gathered and curated from published research articles. It is imperative to note that we bear no liability for inaccuracies or omissions within the data or published scientific literature associated with UV exposure in this resource. Users are advised to exercise personal discretion when assessing the credibility of biomolecules compiled herein. Crucially, the establishment of this resource, focused on UV-affected biomolecules, is driven by the sole goal of facilitating future basic research endeavors to better understand systems-level perturbations. It is essential to underscore that the content herein does not necessarily mirror the views or objectives of our employers or funders.