t-Butyl hydroquinone

Target genes for t-Butyl hydroquinone is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
t-Butyl hydroquinoneNR1H3ATG_DR4_LXR_CIS_up
t-Butyl hydroquinoneCCL26BSK_4H_Eotaxin3_down
t-Butyl hydroquinoneCREB3ATG_CRE_CIS_up
t-Butyl hydroquinoneCEBPBATG_C_EBP_CIS_up
t-Butyl hydroquinoneCOL3A1BSK_hDFCGF_CollagenIII_down
t-Butyl hydroquinoneCSF1BSK_hDFCGF_MCSF_down
t-Butyl hydroquinoneCSF1BSK_CASM3C_MCSF_down
t-Butyl hydroquinoneCSF1BSK_LPS_MCSF_down
t-Butyl hydroquinoneCYP2C19NVS_ADME_hCYP2C19
t-Butyl hydroquinoneCYP2C9NVS_ADME_hCYP2C9
t-Butyl hydroquinoneCYP2D6NVS_ADME_hCYP2D6
t-Butyl hydroquinoneCYP19A1TOX21_Aromatase_Inhibition
t-Butyl hydroquinoneCYP24A1TOX21_VDR_BLA_antagonist_ratio
t-Butyl hydroquinoneE2F1ATG_E2F_CIS_dn
t-Butyl hydroquinoneEGFRBSK_hDFCGF_EGFR_down
t-Butyl hydroquinoneEGR1ATG_EGR_CIS_up
t-Butyl hydroquinoneAHRATG_Ahr_CIS_up
t-Butyl hydroquinoneAHRTOX21_AhR_LUC_Agonist
t-Butyl hydroquinoneESR1OT_ER_ERaERb_1440
t-Butyl hydroquinoneESR1ATG_ERa_TRANS_up
t-Butyl hydroquinoneESR2OT_ER_ERaERb_1440
t-Butyl hydroquinoneESR2TOX21_ERb_BLA_Antagonist_ratio
t-Butyl hydroquinoneESR2OT_ER_ERbERb_1440
t-Butyl hydroquinoneESR2OT_ER_ERbERb_0480
t-Butyl hydroquinoneETS1ATG_Ets_CIS_dn
t-Butyl hydroquinoneF3BSK_LPS_TissueFactor_down
t-Butyl hydroquinoneF3BSK_CASM3C_TissueFactor_up
t-Butyl hydroquinoneFOSATG_AP_1_CIS_up
t-Butyl hydroquinoneNR3C1TOX21_GR_BLA_Antagonist_ratio
t-Butyl hydroquinoneHLA-DRABSK_3C_HLADR_down
t-Butyl hydroquinoneHLA-DRABSK_BE3C_HLADR_down
t-Butyl hydroquinoneHLA-DRABSK_CASM3C_HLADR_down
t-Butyl hydroquinoneHSF1ATG_HSE_CIS_up
t-Butyl hydroquinoneICAM1BSK_3C_ICAM1_down
t-Butyl hydroquinoneICAM1BSK_KF3CT_ICAM1_down
t-Butyl hydroquinoneIGF1RNVS_ENZ_hIGF1R
t-Butyl hydroquinoneIL1ABSK_KF3CT_IL1a_down
t-Butyl hydroquinoneIL1ABSK_LPS_IL1a_down
t-Butyl hydroquinoneCXCL8BSK_LPS_IL8_down
t-Butyl hydroquinoneCXCL8BSK_hDFCGF_IL8_down
t-Butyl hydroquinoneCXCL8BSK_SAg_IL8_down
t-Butyl hydroquinoneCXCL10BSK_hDFCGF_IP10_down
t-Butyl hydroquinoneCXCL10BSK_BE3C_IP10_down
t-Butyl hydroquinoneCXCL10BSK_KF3CT_IP10_down
t-Butyl hydroquinoneIRF1ATG_ISRE_CIS_dn
t-Butyl hydroquinoneARTOX21_AR_BLA_Antagonist_ratio
t-Butyl hydroquinoneARACEA_AR_agonist_80hr
t-Butyl hydroquinoneAROT_AR_ARSRC1_0960
t-Butyl hydroquinoneARACEA_AR_antagonist_80hr
t-Butyl hydroquinoneJUNATG_AP_1_CIS_up
t-Butyl hydroquinoneJUNTOX21_AP1_BLA_Agonist_ratio
t-Butyl hydroquinoneFOSTOX21_AP1_BLA_Agonist_ratio
t-Butyl hydroquinoneSMAD1ATG_BRE_CIS_up
t-Butyl hydroquinoneCXCL9BSK_3C_MIG_down
t-Butyl hydroquinoneCXCL9BSK_hDFCGF_MIG_down
t-Butyl hydroquinoneCXCL9BSK_SAg_MIG_down
t-Butyl hydroquinoneMMP1BSK_hDFCGF_MMP1_down
t-Butyl hydroquinoneMMP1BSK_BE3C_MMP1_up
t-Butyl hydroquinoneMMP9BSK_KF3CT_MMP9_down
t-Butyl hydroquinoneMTF1ATG_MRE_CIS_up
t-Butyl hydroquinoneMYCATG_Myc_CIS_up
t-Butyl hydroquinoneNFIAATG_NFI_CIS_up
t-Butyl hydroquinoneNFE2L2ATG_NRF2_ARE_CIS_up
t-Butyl hydroquinoneNFE2L2TOX21_ARE_BLA_agonist_ratio
t-Butyl hydroquinoneSERPINE1BSK_hDFCGF_PAI1_down
t-Butyl hydroquinoneSERPINE1BSK_BE3C_PAI1_down
t-Butyl hydroquinonePAX6ATG_Pax6_CIS_up
t-Butyl hydroquinoneLEF1ATG_TCF_b_cat_CIS_dn
t-Butyl hydroquinonePGRTOX21_PR_BLA_Antagonist_ratio
t-Butyl hydroquinonePLAUBSK_KF3CT_uPA_down
t-Butyl hydroquinonePOU2F1ATG_Oct_MLP_CIS_up
t-Butyl hydroquinonePPARAATG_PPRE_CIS_up
t-Butyl hydroquinonePPARDATG_PPRE_CIS_up
t-Butyl hydroquinonePPARDTOX21_PPARd_BLA_antagonist_ratio
t-Butyl hydroquinonePPARGATG_PPRE_CIS_up
t-Butyl hydroquinonePPARGATG_PPARg_TRANS_up
t-Butyl hydroquinonePTGER2BSK_LPS_PGE2_down
t-Butyl hydroquinoneRORAATG_RORE_CIS_up
t-Butyl hydroquinoneRORBATG_RORE_CIS_up
t-Butyl hydroquinoneRORCATG_RORE_CIS_up
t-Butyl hydroquinoneRXRAOT_NURR1_NURR1RXRa_0480
t-Butyl hydroquinoneRXRAOT_NURR1_NURR1RXRa_1440
t-Butyl hydroquinoneRXRBATG_RXRb_TRANS_dn
t-Butyl hydroquinoneCCL2BSK_LPS_MCP1_down
t-Butyl hydroquinoneCCL2BSK_SAg_MCP1_down
t-Butyl hydroquinoneCCL2BSK_KF3CT_MCP1_down
t-Butyl hydroquinoneCCL2BSK_CASM3C_MCP1_down
t-Butyl hydroquinoneCCL2BSK_3C_MCP1_down
t-Butyl hydroquinoneSELEBSK_LPS_Eselectin_down
t-Butyl hydroquinoneSELEBSK_3C_Eselectin_down
t-Butyl hydroquinoneSELEBSK_SAg_Eselectin_down
t-Butyl hydroquinoneSELPBSK_4H_Pselectin_down
t-Butyl hydroquinoneSLC6A2NVS_TR_hNET
t-Butyl hydroquinoneSOX1ATG_Sox_CIS_up
t-Butyl hydroquinoneSP1ATG_Sp1_CIS_up
t-Butyl hydroquinoneTACR2NVS_GPCR_hNK2
t-Butyl hydroquinoneTCF7ATG_TCF_b_cat_CIS_dn
t-Butyl hydroquinoneTCF7L2ATG_TCF_b_cat_CIS_dn
t-Butyl hydroquinoneTGFB1BSK_KF3CT_TGFb1_down
t-Butyl hydroquinoneTHBDBSK_3C_Thrombomodulin_up
t-Butyl hydroquinoneTHBDBSK_CASM3C_Thrombomodulin_up
t-Butyl hydroquinoneTIMP1BSK_hDFCGF_TIMP1_down
t-Butyl hydroquinoneTIMP2BSK_KF3CT_TIMP2_down
t-Butyl hydroquinoneTNFBSK_LPS_TNFa_down
t-Butyl hydroquinoneNR1H2ATG_DR4_LXR_CIS_up
t-Butyl hydroquinoneNR1H2ATG_LXRb_TRANS_dn
t-Butyl hydroquinoneVCAM1BSK_4H_VCAM1_down
t-Butyl hydroquinoneVCAM1BSK_CASM3C_VCAM1_down
t-Butyl hydroquinoneVCAM1BSK_LPS_VCAM1_down
t-Butyl hydroquinoneVCAM1BSK_3C_VCAM1_down
t-Butyl hydroquinoneVCAM1BSK_hDFCGF_VCAM1_down
t-Butyl hydroquinoneVDRTOX21_VDR_BLA_antagonist_ratio
t-Butyl hydroquinoneVDRATG_VDRE_CIS_up
t-Butyl hydroquinoneXBP1ATG_Xbp1_CIS_up
t-Butyl hydroquinoneTCF7L1ATG_TCF_b_cat_CIS_dn
t-Butyl hydroquinoneNR1I2ATG_PXRE_CIS_up
t-Butyl hydroquinoneNR1I2ATG_PXR_TRANS_up
t-Butyl hydroquinoneCD38BSK_SAg_CD38_down
t-Butyl hydroquinoneCD40BSK_LPS_CD40_down
t-Butyl hydroquinoneCD40BSK_SAg_CD40_down
t-Butyl hydroquinoneCD69BSK_SAg_CD69_down
t-Butyl hydroquinoneNR1I3TOX21_CAR_Agonist
t-Butyl hydroquinoneNR1H4TOX21_FXR_BLA_antagonist_ratio
t-Butyl hydroquinoneNR1H4OT_FXR_FXRSRC1_1440
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.