Resveratrol

Target genes for Resveratrol is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
ResveratrolNR1H3ATG_DR4_LXR_CIS_dn
ResveratrolADORA1NVS_GPCR_hAdoRA1
ResveratrolADORA2ANVS_GPCR_hAdoRA2a
ResveratrolCYP2C19NVS_ADME_hCYP2C19
ResveratrolCYP2C9NVS_ADME_hCYP2C9
ResveratrolCYP2D6NVS_ADME_hCYP2D6
ResveratrolCYP3A4NVS_ADME_hCYP3A4_Activator
ResveratrolDRD1NVS_GPCR_hDRD1
ResveratrolAHRTOX21_AhR_LUC_Agonist
ResveratrolEPHA1NVS_ENZ_hEphA1
ResveratrolESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
ResveratrolESR1TOX21_ERa_LUC_VM7_Agonist
ResveratrolESR1ACEA_ER_80hr
ResveratrolESR1NVS_NR_hER
ResveratrolESR1ATG_ERE_CIS_up
ResveratrolESR1TOX21_ERa_BLA_Antagonist_ratio
ResveratrolESR1TOX21_ERa_BLA_Agonist_ratio
ResveratrolESR1ATG_ERa_TRANS_up
ResveratrolESR2TOX21_ERb_BLA_Agonist_ratio
ResveratrolESR2TOX21_ERb_BLA_Antagonist_ratio
ResveratrolESRRATOX21_ERR_Agonist
ResveratrolESRRATOX21_PGC_ERR_Agonist
ResveratrolETS1ATG_Ets_CIS_dn
ResveratrolF3BSK_CASM3C_TissueFactor_down
ResveratrolF3BSK_3C_TissueFactor_down
ResveratrolFLT1NVS_ENZ_hVEGFR1_Activator
ResveratrolNR3C1NVS_NR_hGR
ResveratrolHDAC1TOX21_HDAC_Inhibition
ResveratrolHLA-DRABSK_3C_HLADR_down
ResveratrolHLA-DRABSK_BE3C_HLADR_down
ResveratrolIL1ABSK_BE3C_IL1a_down
ResveratrolIL1ABSK_KF3CT_IL1a_down
ResveratrolIL6BSK_CASM3C_IL6_down
ResveratrolCXCL8BSK_LPS_IL8_down
ResveratrolCXCL10BSK_BE3C_IP10_down
ResveratrolIRF1ATG_ISRE_CIS_dn
ResveratrolARTOX21_AR_LUC_MDAKB2_Agonist
ResveratrolARTOX21_AR_BLA_Antagonist_ratio
ResveratrolSMAD1ATG_BRE_CIS_up
ResveratrolMMP9BSK_KF3CT_MMP9_down
ResveratrolMTF1ATG_MRE_CIS_up
ResveratrolNFE2L2ATG_NRF2_ARE_CIS_up
ResveratrolNFE2L2TOX21_ARE_BLA_agonist_ratio
ResveratrolNFKB1ATG_NF_kB_CIS_up
ResveratrolNRF1ATG_NRF1_CIS_dn
ResveratrolNR4A2ATG_NURR1_TRANS_up
ResveratrolSERPINE1BSK_hDFCGF_PAI1_up
ResveratrolPAX6ATG_Pax6_CIS_up
ResveratrolLEF1ATG_TCF_b_cat_CIS_dn
ResveratrolPGRNVS_NR_hPR
ResveratrolPGRTOX21_PR_BLA_Antagonist_ratio
ResveratrolPLAURBSK_4H_uPAR_up
ResveratrolPLAURBSK_BE3C_uPAR_up
ResveratrolPLAURBSK_CASM3C_uPAR_up
ResveratrolPPARAATG_PPRE_CIS_up
ResveratrolPPARDATG_PPRE_CIS_up
ResveratrolPPARGATG_PPARg_TRANS_up
ResveratrolPPARGATG_PPRE_CIS_up
ResveratrolPPARGTOX21_PPARg_BLA_antagonist_ratio
ResveratrolPTGER2BSK_LPS_PGE2_down
ResveratrolRORBATG_RORb_TRANS_up
ResveratrolRORCATG_RORg_TRANS_up
ResveratrolSAA1BSK_CASM3C_SAA_up
ResveratrolCCL2BSK_3C_MCP1_down
ResveratrolCCL2BSK_CASM3C_MCP1_up
ResveratrolCCL2BSK_4H_MCP1_down
ResveratrolCCL2BSK_KF3CT_MCP1_down
ResveratrolCCL2BSK_LPS_MCP1_down
ResveratrolSLC6A2NVS_TR_hNET
ResveratrolSLC6A3NVS_TR_hDAT
ResveratrolSREBF1ATG_SREBP_CIS_up
ResveratrolTACR2NVS_GPCR_hNK2
ResveratrolTBXA2RNVS_GPCR_hTXA2
ResveratrolTCF7ATG_TCF_b_cat_CIS_dn
ResveratrolTCF7L2ATG_TCF_b_cat_CIS_dn
ResveratrolTGFB1ATG_TGFb_CIS_dn
ResveratrolTIMP2BSK_KF3CT_TIMP2_down
ResveratrolTP53TOX21_p53_BLA_p1_ratio
ResveratrolNR1H2ATG_DR4_LXR_CIS_dn
ResveratrolATAD5TOX21_ELG1_LUC_Agonist
ResveratrolTCF7L1ATG_TCF_b_cat_CIS_dn
ResveratrolNR1I3TOX21_CAR_Agonist
ResveratrolNR1I3ATG_PBREM_CIS_up
ResveratrolNR1H4ATG_IR1_CIS_dn
ResveratrolNR1H4TOX21_FXR_BLA_antagonist_ratio

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.