Benzophenone-2

Target genes for Benzophenone-2 is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
Benzophenone-2CDK2NVS_ENZ_hCDK2
Benzophenone-2ADORA1NVS_GPCR_hAdoRA1
Benzophenone-2ADORA2ANVS_GPCR_hAdoRA2a
Benzophenone-2CSF1RNVS_ENZ_hCSF1R
Benzophenone-2CSNK1DNVS_ENZ_hCK1D
Benzophenone-2CYP1A2NVS_ADME_hCYP1A2
Benzophenone-2CYP2B6NVS_ADME_hCYP2B6
Benzophenone-2CYP2C19NVS_ADME_hCYP2C19
Benzophenone-2CYP3A4NVS_ADME_hCYP3A4
Benzophenone-2CYP19A1NVS_ADME_hCYP19A1
Benzophenone-2CYP19A1TOX21_Aromatase_Inhibition
Benzophenone-2EGFRNVS_ENZ_hEGFR
Benzophenone-2AHRTOX21_AhR_LUC_Agonist
Benzophenone-2EPHA1NVS_ENZ_hEphA1
Benzophenone-2ESR1OT_ER_ERaERb_1440
Benzophenone-2ESR1OT_ER_ERaERa_0480
Benzophenone-2ESR1OT_ERa_EREGFP_0480
Benzophenone-2ESR1TOX21_ERa_LUC_VM7_Agonist
Benzophenone-2ESR1ACEA_ER_80hr
Benzophenone-2ESR1OT_ERa_EREGFP_0120
Benzophenone-2ESR1ATG_ERa_TRANS_up
Benzophenone-2ESR1ATG_ERE_CIS_up
Benzophenone-2ESR1TOX21_ERa_BLA_Agonist_ratio
Benzophenone-2ESR1OT_ER_ERaERa_1440
Benzophenone-2ESR1NVS_NR_hER
Benzophenone-2ESR1OT_ER_ERaERb_0480
Benzophenone-2ESR2OT_ER_ERbERb_1440
Benzophenone-2ESR2OT_ER_ERaERb_0480
Benzophenone-2ESR2TOX21_ERb_BLA_Agonist_ratio
Benzophenone-2ESR2OT_ER_ERaERb_1440
Benzophenone-2ESR2OT_ER_ERbERb_0480
Benzophenone-2ESRRATOX21_PGC_ERR_Agonist
Benzophenone-2F3BSK_3C_TissueFactor_down
Benzophenone-2FGFR1NVS_ENZ_hFGFR1
Benzophenone-2FLT1NVS_ENZ_hVEGFR1
Benzophenone-2FYNNVS_ENZ_hFyn
Benzophenone-2NR3C1NVS_NR_hGR
Benzophenone-2NR3C1TOX21_GR_BLA_Antagonist_ratio
Benzophenone-2GSK3BNVS_ENZ_hGSK3b
Benzophenone-2HDAC1TOX21_HDAC_Inhibition
Benzophenone-2HLA-DRABSK_BE3C_HLADR_down
Benzophenone-2HSF1ATG_HSE_CIS_up
Benzophenone-2HSF1TOX21_HSE_BLA_agonist_ratio
Benzophenone-2HTR6NVS_GPCR_h5HT6
Benzophenone-2CXCL10BSK_BE3C_IP10_down
Benzophenone-2CXCL10BSK_hDFCGF_IP10_down
Benzophenone-2INSRNVS_ENZ_hInsR
Benzophenone-2ARNVS_NR_hAR
Benzophenone-2AROT_AR_ARSRC1_0480
Benzophenone-2AROT_AR_ARSRC1_0960
Benzophenone-2ARTOX21_AR_LUC_MDAKB2_Agonist_3uM_Nilutamide
Benzophenone-2ARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
Benzophenone-2ARTOX21_AR_BLA_Antagonist_ratio
Benzophenone-2ARACEA_AR_antagonist_80hr
Benzophenone-2ARACEA_AR_agonist_80hr
Benzophenone-2JAK2NVS_ENZ_hJak2
Benzophenone-2KDRNVS_ENZ_hVEGFR2
Benzophenone-2NFE2L2TOX21_ARE_BLA_agonist_ratio
Benzophenone-2NRF1ATG_NRF1_CIS_dn
Benzophenone-2NTRK1NVS_ENZ_hTrkA
Benzophenone-2OPRD1NVS_GPCR_hOpiate_D1
Benzophenone-2SERPINE1BSK_hDFCGF_PAI1_up
Benzophenone-2SERPINE1BSK_BE3C_PAI1_down
Benzophenone-2LEF1ATG_TCF_b_cat_CIS_dn
Benzophenone-2PGRTOX21_PR_BLA_Antagonist_ratio
Benzophenone-2PGRNVS_NR_hPR
Benzophenone-2PPARAATG_PPRE_CIS_up
Benzophenone-2PPARDTOX21_PPARd_BLA_antagonist_ratio
Benzophenone-2PPARDATG_PPRE_CIS_up
Benzophenone-2PPARGATG_PPRE_CIS_up
Benzophenone-2PPARGATG_PPARg_TRANS_up
Benzophenone-2PPARGTOX21_PPARg_BLA_antagonist_ratio
Benzophenone-2RARANVS_NR_hRARa_Agonist
Benzophenone-2SELEBSK_SAg_Eselectin_up
Benzophenone-2SRCNVS_ENZ_hSRC
Benzophenone-2AURKANVS_ENZ_hAurA
Benzophenone-2TCF7ATG_TCF_b_cat_CIS_dn
Benzophenone-2TCF7L2ATG_TCF_b_cat_CIS_dn
Benzophenone-2TP53TOX21_p53_BLA_p2_ratio
Benzophenone-2TP53TOX21_p53_BLA_p5_ratio
Benzophenone-2TP53TOX21_p53_BLA_p1_ratio
Benzophenone-2TP53TOX21_p53_BLA_p4_ratio
Benzophenone-2TP53TOX21_p53_BLA_p3_ratio
Benzophenone-2TCF7L1ATG_TCF_b_cat_CIS_dn
Benzophenone-2PDE5ANVS_ENZ_hPDE5
Benzophenone-2RPS6KA5NVS_ENZ_hMsk1
Benzophenone-2NR1H4OT_FXR_FXRSRC1_1440
Benzophenone-2NR1H4TOX21_FXR_BLA_antagonist_ratio

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.