Indian Medicinal Plants, Phytochemistry And Therapeutics (IMPPAT) is a curated database which has been constructed via literature mining followed by manual curation of information gathered from more than 50 specialized books on traditional Indian medicine, more than 7000 abstracts of published research articles and other existing database resources. The schematic figure 1 gives an overview of the IMPPAT database construction pipeline.
IMPPAT database captures three different types of associations:
Our database captures >1700 Indian medicinal plants, >9500 phytochemicals, >1100 therapeutic uses and >900 traditional Indian medicinal formulations.
Importantly, for the >9500 phytochemicals in this database, we provide the two-dimensional (2D) and three-dimensional (3D) chemical structures, and have employed cheminformatics tools to compute their physicochemical properties, drug-likeliness based on multiple scoring schemes and predicted Absorption, distribution, metabolism, excretion and toxicity (ADMET) properties.
In a nutshell, IMPPAT is the largest database on phytochemicals of Indian medicinal plants to date, and this resource is a culmination of our efforts to digitize the wealth of information contained within traditional Indian medicine. IMPPAT provides an integrated platform to apply cheminformatic approaches to accelerate natural product based drug discovery. IMPPAT is also expected to enable application of system-level approaches towards future elucidation of mechanistic links between phytochemicals of Indian medicinal plants and their therapeutic action.
We welcome suggestions from researchers in academia and industry for future improvements of our database.
Note that a subset of the compiled information in the IMPPAT database is accessible anonymously or without logging in. Complete information in the IMPPAT database is accessible to academic researchers for non-commercial research. Such academic researchers should request login access from the database administrators using the registration page in IMPPAT database. The owners of the IMPPAT database reserve the right to refuse login access without specifying any reason.