IMPPAT Phytochemical information: 
N-Coumaroyl serotonin
N-Coumaroyl serotonin
Summary

SMILES: O=C(/C=C/c1ccc(cc1)O)NCCc1c[nH]c2c1cc(O)cc2
InChI: InChI=1S/C19H18N2O3/c22-15-4-1-13(2-5-15)3-8-19(24)20-10-9-14-12-21-18-7-6-16(23)11-17(14)18/h1-8,11-12,21-23H,9-10H2,(H,20,24)/b8-3+
InChIKey: WLZPAFGVOWCVMG-FPYGCLRLSA-N
DeepSMILES: O=C/C=C/cccccc6))O)))))))NCCcc[nH]cc5ccO)cc6
Scaffold Graph/Node/Bond level: O=C(C=Cc1ccccc1)NCCc1c[nH]c2ccccc12
Scaffold Graph/Node level: OC(CCC1CCCCC1)NCCC1CNC2CCCCC12
Scaffold Graph level: CC(CCCC1CCC2CCCCC21)CCC1CCCCC1
Functional groups: c/C=C/C(=O)NC; cO; c[nH]c
Chemical classification
ClassyFire Kingdom: Organic compounds
ClassyFire Superclass: Organoheterocyclic compounds
ClassyFire Class: Indoles and derivatives
ClassyFire Subclass: Tryptamines and derivatives
NP Classifier Biosynthetic pathway: Amino acids and Peptides|Shikimates and Phenylpropanoids
NP Classifier Superclass: Phenylpropanoids (C6-C3)
NP Classifier Class: Cinnamic acid amides
Synonymous chemical names:
n-p-coumaroyl serotonin
External chemical identifiers:
CID:CID_5458879; ChEMBL:CHEMBL1760547; ChEBI:CHEBI:175113; ZINC:ZINC000001587152; FDASRS:IUC27Q8ACH; SureChEMBL:SCHEMBL471921; MolPort-003-846-030
Chemical structure download
2D:2D MOL2D MOL22D SDF
3D:3D MOL3D MOL23D SDF3D PDB3D PDBQT
N-Coumaroyl serotonin
Physicochemical properties
Property name Tool Property value
Molecular weight (g/mol) RDKit 322.36
Log P RDKit 2.95
Topological polar surface area (Å2) RDKit 85.35
Number of hydrogen bond acceptors RDKit 3
Number of hydrogen bond donors RDKit 4
Number of carbon atoms RDKit 19
Number of heavy atoms RDKit 24
Number of heteroatoms RDKit 5
Number of nitrogen atoms RDKit 2
Number of sulfur atoms RDKit 0
Number of chiral carbon atoms RDKit 0
Stereochemical complexity RDKit 0
Number of sp hybridized carbon atoms RDKit 0
Number of sp2 hybridized carbon atoms RDKit 17
Number of sp3 hybridized carbon atoms RDKit 2
Shape complexity RDKit 0.11
Number of rotatable bonds RDKit 5
Number of aliphatic carbocycles RDKit 0
Number of aliphatic heterocycles RDKit 0
Number of aliphatic rings RDKit 0
Number of aromatic carbocycles RDKit 2
Number of aromatic heterocycles RDKit 1
Number of aromatic rings RDKit 3
Total number of rings RDKit 3
Number of saturated carbocycles RDKit 0
Number of saturated heterocycles RDKit 0
Number of saturated rings RDKit 0
Number of Smallest Set of Smallest Rings (SSSR) RDKit 3
N-Coumaroyl serotonin
Drug-likeness properties
Property nameToolProperty value
Number of Lipinski’s rule of 5 violations RDKit 0
Lipinski’s rule of 5 filter RDKit Passed
Number of Ghose filter violations RDKit 0
Ghose filter RDKit Passed
Veber filter RDKit Good
Pfizer 3/75 filter RDKit Good
GSK 4/400 filter RDKit Good
Weighted quantitative estimate of drug-likeness (QEDw) score RDKit 0.544864
N-Coumaroyl serotonin
ADME properties
Property nameToolProperty value
Bioavailability score SwissADME 0.55
Solubility class [ESOL] SwissADME Soluble
Solubility class [Silicos-IT] SwissADME Moderately soluble
Blood Brain Barrier permeation SwissADME No
Gastrointestinal absorption SwissADME High
Log Kp (Skin permeation, cm/s) SwissADME -6.14
Number of PAINS structural alerts SwissADME 0
Number of Brenk structural alerts SwissADME 1
CYP1A2 inhibitor SwissADME Yes
CYP2C19 inhibitor SwissADME No
CYP2C9 inhibitor SwissADME No
CYP2D6 inhibitor SwissADME Yes
CYP3A4 inhibitor SwissADME No
P-glycoprotein substrate SwissADME No