IMPPAT Phytochemical information: 
8beta-Hydroxycoronopilin
8beta-Hydroxycoronopilin
Summary

SMILES: O[C@@H]1C[C@@]2([C@](C1=O)(C)[C@@H]1OC(=O)C(=C)[C@@H]1CC[C@@H]2C)O
InChI: InChI=1S/C15H20O5/c1-7-4-5-9-8(2)13(18)20-12(9)14(3)11(17)10(16)6-15(7,14)19/h7,9-10,12,16,19H,2,4-6H2,1,3H3/t7-,9-,10+,12+,14-,15+/m0/s1
InChIKey: GTJROBKZCHTNPV-KSWRHCHDSA-N
DeepSMILES: O[C@@H]C[C@@][C@]C5=O))C)[C@@H]OC=O)C=C)[C@@H]5CC[C@@H]%10C))))))))))O
Scaffold Graph/Node/Bond level: C=C1C(=O)OC2C1CCCC1CCC(=O)C12
Scaffold Graph/Node level: CC1C(O)OC2C1CCCC1CCC(O)C12
Scaffold Graph level: CC1CC2C(CCCC3CCC(C)C32)C1C
Functional groups: CO; CC(=O)C; C=C1CCOC1=O
Chemical classification
ClassyFire Kingdom: Organic compounds
ClassyFire Superclass: Lipids and lipid-like molecules
ClassyFire Class: Prenol lipids
ClassyFire Subclass: Terpene lactones
NP Classifier Biosynthetic pathway: Terpenoids
NP Classifier Superclass: Sesquiterpenoids
NP Classifier Class: Pseudoguaiane sesquiterpenoids
Synonymous chemical names:
8β-hydroxycoronopilin, 8beta-hydroxycoronopilin
External chemical identifiers:
CID:CID_102176995
Chemical structure download
2D:2D MOL2D MOL22D SDF
3D:3D MOL3D MOL23D SDF3D PDB3D PDBQT
8beta-Hydroxycoronopilin
Physicochemical properties
Property name Tool Property value
Molecular weight (g/mol) RDKit 280.32
Log P RDKit 0.59
Topological polar surface area (Å2) RDKit 83.83
Number of hydrogen bond acceptors RDKit 5
Number of hydrogen bond donors RDKit 2
Number of carbon atoms RDKit 15
Number of heavy atoms RDKit 20
Number of heteroatoms RDKit 5
Number of nitrogen atoms RDKit 0
Number of sulfur atoms RDKit 0
Number of chiral carbon atoms RDKit 6
Stereochemical complexity RDKit 0.4
Number of sp hybridized carbon atoms RDKit 0
Number of sp2 hybridized carbon atoms RDKit 4
Number of sp3 hybridized carbon atoms RDKit 11
Shape complexity RDKit 0.73
Number of rotatable bonds RDKit 0
Number of aliphatic carbocycles RDKit 2
Number of aliphatic heterocycles RDKit 1
Number of aliphatic rings RDKit 3
Number of aromatic carbocycles RDKit 0
Number of aromatic heterocycles RDKit 0
Number of aromatic rings RDKit 0
Total number of rings RDKit 3
Number of saturated carbocycles RDKit 2
Number of saturated heterocycles RDKit 1
Number of saturated rings RDKit 3
Number of Smallest Set of Smallest Rings (SSSR) RDKit 3
8beta-Hydroxycoronopilin
Drug-likeness properties
Property nameToolProperty value
Number of Lipinski’s rule of 5 violations RDKit 0
Lipinski’s rule of 5 filter RDKit Passed
Number of Ghose filter violations RDKit 0
Ghose filter RDKit Passed
Veber filter RDKit Good
Pfizer 3/75 filter RDKit Good
GSK 4/400 filter RDKit Good
Weighted quantitative estimate of drug-likeness (QEDw) score RDKit 0.500869
8beta-Hydroxycoronopilin
ADME properties
Property nameToolProperty value
Bioavailability score SwissADME 0.55
Solubility class [ESOL] SwissADME Very soluble
Solubility class [Silicos-IT] SwissADME Soluble
Blood Brain Barrier permeation SwissADME No
Gastrointestinal absorption SwissADME High
Log Kp (Skin permeation, cm/s) SwissADME -7.81
Number of PAINS structural alerts SwissADME 0
Number of Brenk structural alerts SwissADME 1
CYP1A2 inhibitor SwissADME No
CYP2C19 inhibitor SwissADME No
CYP2C9 inhibitor SwissADME No
CYP2D6 inhibitor SwissADME No
CYP3A4 inhibitor SwissADME No
P-glycoprotein substrate SwissADME Yes