IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
MCF7	Homo sapiens			= 12580.0 nM\|= 21560.0 nM			NPASS
L-lactate dehydrogenase	Plasmodium falciparum (isolate CDC / Honduras)	Q27743		2640 nM			BindingDB
Lactate dehydrogenase	Plasmodium falciparum	Q0PJ46		= 2640.0 nM			NPASS
L-lactate dehydrogenase B chain	Mus musculus	P16125				1400 nM\|= 1400.0 nM	BindingDB, NPASS
L-lactate dehydrogenase B chain	Homo sapiens	P07195				1400 nM\|= 1400.0 nM	BindingDB, NPASS
L-lactate dehydrogenase B chain	Bos taurus	Q5E9B1		9540 nM			BindingDB
L-lactate dehydrogenase A chain	Homo sapiens	P00338				1900 nM\|= 1900.0 nM	BindingDB, NPASS
L-lactate dehydrogenase	Plasmodium falciparum			2030 nM\|3.97e+3 nM			BindingDB
Inosine-5'-monophosphate dehydrogenase	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1)	Q9HXM5		= 900.0 nM			NPASS
Kinesin-like protein KIF11	Homo sapiens	P52732		25000 nM\|10800 nM			BindingDB
Kinesin-like protein 1	Homo sapiens	P52732		= 25000.0 nM\|= 10800.0 nM			NPASS
KB	Homo sapiens			= 0.04 ug.mL-1			NPASS
K562	Homo sapiens			= 4550.0 nM\|= 7310.0 nM\|= 5910.0 nM\|= 8280.0 nM			NPASS
Inosine-5'-monophosphate dehydrogenase	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)			900 nM			BindingDB
Influenza A virus (H5N1)	InflueA virus (H5N1)			= 2140.0 nM			NPASS
MCF7S	Homo sapiens			= 13200.0 nM			NPASS
L-lactate dehydrogenase	Bos taurus			6.9e+3 nM			BindingDB
MDA-MB-231	Homo sapiens			= 1900.0 nM\|= 3700.0 nM\|= 9210.0 nM\|= 4800.0 nM\|= 9420.0 nM\|= 8540.0 nM			NPASS
Solute carrier organic anion transporter family member 1B3	Homo sapiens	Q9NPD5		4571 nM\|= 4570.88 nM		3470 nM\|= 3470.0 nM	BindingDB, NPASS
Malate dehydrogenase	Plasmodium falciparum	Q6VVP7		= 2030.0 nM			NPASS
p53-binding protein Mdm-2	Homo sapiens	Q00987				> 25000.0 nM	NPASS
ZR-75-1	Homo sapiens			= 8400.0 nM			NPASS
Transitional endoplasmic reticulum ATPase	Human	P55072		5386 nM\|15540 nM			BindingDB
Transitional endoplasmic reticulum ATPase	Homo sapiens	P55072		6530 nM			BindingDB
Thiosulfate sulfurtransferase	Homo sapiens	Q16762		11000 nM			BindingDB
Influenza A virus	InflueA virus			= 3820.0 nM\|= 1870.0 nM			NPASS
Solute carrier organic anion transporter family member 1B1	Homo sapiens	Q9Y6L6		3236 nM\|= 3235.94 nM		1780 nM\|= 1780.0 nM	BindingDB, NPASS
MDA-MB-435	Homo sapiens			= 11780.0 nM\|= 33250.0 nM			NPASS
SW-620	Homo sapiens			= 12580.0 nM\|= 21560.0 nM			NPASS
Plasmodium falciparum	Plasmodium falciparum			= 13000.0 nM\|= 7000.0 nM\|= 4500.0 nM\|= 12000.0 nM\|= 47900.0 nM			NPASS
PC-3	Homo sapiens		= 17800.0 nM\|= 3300.0 nM	= 2500.0 nM\|= 9140.0 nM\|= 22360.0 nM\|= 6.71 ug.mL-1\|= 5610.0 nM\|= 8580.0 nM			NPASS
NON-PROTEIN TARGET			= 3100.0 nM\|= 6000.0 nM	= 30200.0 nM\|= 59600.0 nM\|= 18400.0 nM\|= 39700.0 nM\|= 5.56 ug.mL-1\|= 6260.0 nM\|= 5780.0 nM\|= 6600.0 nM\|= 7970.0 nM\|= 19170.0 nM\|= 7930.0 nM\|= 54000.0 nM\|= 75000.0 nM\|= 60100.0 nM\|= 3590.0 nM\|= 5010.0 nM\|= 3030.0 nM\|= 23200.0 nM\|= 61900.0 nM\|= 46780.0 nM\|= 9230.0 nM\|= 7540.0 nM\|= 5600.0 nM			NPASS
NCI-H460	Homo sapiens		= 3000.0 nM				NPASS
Malate dehydrogenase, mitochondrial	Sus scrofa	P00346		2800 nM			BindingDB
Malate dehydrogenase mitochondrial	Sus scrofa	P00346		= 2800.0 nM			NPASS
Malate dehydrogenase cytoplasmic	Sus scrofa	P11708		= 5800.0 nM			NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM			NPASS
Induced myeloid leukemia cell differentiation protein Mcl-1/BH3-interacting domain death agonist	Homo sapiens			= 1750.0 nM			NPASS
Malate dehydrogenase, cytoplasmic	Sus scrofa	P11708		5800 nM			BindingDB
HepG2	Homo sapiens			= 10.16 ug.mL-1			NPASS
Bcl2-antagonist of cell death (BAD)	Homo sapiens	Q92934				= 460.0 nM	NPASS
Bcl-xL/BH3-interacting domain death agonist	Homo sapiens			= 3030.0 nM			NPASS
Bcl-2-like protein 2	Homo sapiens	Q92843				17700 nM	BindingDB
Bcl-2-like protein 1	Homo sapiens	Q07817		2720 nM\|540 nM\|500 nM	1710 nM\|3.38E5 nM	1000 nM\|620 nM\|480 nM\|640 nM\|310 nM\|1400 nM\|770 nM\|610 nM	BindingDB
B16-F10	Mus musculus			= 5540.0 nM\|= 17970.0 nM			NPASS
Aspartyl/asparaginyl beta-hydroxylase	Homo sapiens	Q12797		250 nM\|260 nM\|330 nM\|= 250.0 nM\|= 260.0 nM\|= 330.0 nM			BindingDB, NPASS
Apoptosis regulator Bcl-X	Homo sapiens	Q07817		= 2720 nM\|= 500.0 nM\|= 480.0 nM\|= 540.0 nM\|= 2720.0 nM	= 1710.0 nM\|= 338000.0 nM	= 480.0 nM\|= 1000.0 nM\|= 640.0 nM\|= 770.0 nM\|= 310.0 nM\|= 1400.0 nM\|= 610.0 nM	NPASS
Bcl2-associated agonist of cell death	Homo sapiens	Q92934				460 nM	BindingDB
Apoptosis regulator Bcl-W	Homo sapiens	Q92843				= 17700.0 nM	NPASS
Androgen receptor	Homo sapiens	P10275		7160 nM			BindingDB
Androgen Receptor	Homo sapiens	P10275		= 7160.0 nM			NPASS
Aldose reductase	Homo sapiens	P15121				= 500.0 nM	NPASS
Aldo-keto reductase family 1 member B1	Homo sapiens	P15121				500 nM	BindingDB
A549	Homo sapiens			= 1320.0 nM\|= 33080.0 nM			NPASS
4T1	Mus musculus			= 18780.0 nM\|= 21530.0 nM			NPASS
Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens	Q07820		1355.6921 nM\|1523.102004 nM\|856 nM\|4800 nM\|170 nM\|1520 nM\|= 1523.1 nM\|= 4800.0 nM\|= 170.0 nM\|= 856.0 nM\|= 1520.0 nM	2324 nM\|2650 nM\|= 2324.0 nM\|= 2650.0 nM\|= 2630.27 nM	180 nM\|280 nM\|310 nM\|640 nM\|162 nM\|200 nM\|6543 nM\|190 nM\|390 nM\|260 nM\|= 180.0 nM\|= 280.0 nM\|= 6543.0 nM\|= 190.0 nM\|= 213.8 nM\|= 310.0 nM\|= 390.0 nM\|= 260.0 nM\|= 640.0 nM\|= 162.0 nM\|= 200.0 nM\|= 450.0 nM	BindingDB, NPASS
Apoptosis regulator Bcl-2	Homo sapiens	P10415		300 nM\|500 nM\|1191 nM\|600 nM\|2110 nM\|= 500.0 nM\|= 300.0 nM\|= 260.0 nM\|= 2110.0 nM\|= 1191.0 nM\|= 600.0 nM	4800 nM\|= 4800.0 nM	320 nM\|170 nM\|440 nM\|511 nM\|450 nM\|420 nM\|10100 nM\|558 nM\|560 nM\|431 nM\|= 320.0 nM\|= 170.0 nM\|= 10100.0 nM\|= 467.74 nM\|= 558.0 nM\|= 620.0 nM\|= 560.0 nM\|= 431.0 nM\|= 440.0 nM\|= 511.0 nM\|= 450.0 nM\|= 420.0 nM	BindingDB, NPASS
Beta-lactamase	Escherichia coli (strain K12)	P00811		46000 nM\|82000 nM			BindingDB
60 kDa heat shock protein, mitochondrial	Homo sapiens	P10809		1200 nM			BindingDB
CT26	Mus musculus			= 2210.0 nM\|= 13590.0 nM			NPASS
HT-29	Homo sapiens			> 5.0 ug.mL-1			NPASS
HEK293	Homo sapiens			= 11040.0 nM			NPASS
HCT-116	Homo sapiens			= 3330.0 nM\|= 21990.0 nM			NPASS
Glucose transporter	Homo sapiens	P11166				= 20000.0 nM	NPASS
Estrogen receptor beta	Human	Q92731		50000 nM			BindingDB
Estrogen receptor alpha	Homo sapiens	P03372		= 2551.34 nM			NPASS
Estrogen receptor	Human	P03372		2551.34 nM			BindingDB
Eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	Q04637		64000 nM			BindingDB
E3 ubiquitin-protein ligase Mdm2	Homo sapiens	Q00987				>25000 nM	BindingDB
DNA-3-methyladenine glycosylase	Homo sapiens	P29372		3000 nM\|= 3000.0 nM			BindingDB, NPASS
DNA repair protein RAD52 homolog	Homo sapiens	P43351		<5000 nM\|< 5000.0 nM			BindingDB, NPASS
Co-chaperonin GroES	Escherichia coli			430 nM\|660 nM			BindingDB
HeLa	Homo sapiens			= 0.08 ug.mL-1\|= 17800.0 nM\|= 31300.0 nM			NPASS
Chaperonin GroEL	Escherichia coli			>250000 nM			BindingDB
Caspase-1	Homo sapiens	P29466		1.23e+3 nM			BindingDB
Entamoeba histolytica	Eoeba histolytica			= 0.00777 ug.mL-1			NPASS
Beta-lactamase AmpC	Escherichia coli K-12	P00811		= 82000.0 nM\|= 46000.0 nM			NPASS

a curated database

IMPPAT Phytochemical information:
Gossypol

Bioactivity information

IMPPAT Phytochemical information: Gossypol

Bioactivity information

IMPPAT Phytochemical information:
Gossypol