IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Multidrug resistance-associated protein 1	Homo sapiens	P33527		20000 nM\|= 20000.0 nM		2400 nM\|13300 nM\|= 2400.0 nM\|= 13300.0 nM	BindingDB, NPASS
Neuraminidase	InflueA virus (A/Puerto Rico/8/1934(H1N1))	P03468		= 26.29 ug.mL-1			NPASS
Myosin light chain kinase, smooth muscle	Homo sapiens	Q15746				1700 nM\|= 1700.0 nM	BindingDB, NPASS
NAD-dependent protein deacetylase sirtuin-6	Homo sapiens	Q8N6T7	= 404000.0 nM				NPASS
NAD-dependent protein deacylase sirtuin-6	Homo sapiens	Q8N6T7	404000 nM				BindingDB
NON-PROTEIN TARGET				= 330.0 nM\|= 139.6 ug.mL-1\|> 100000.0 nM			NPASS
Neuraminidase	InflueA virus	B4URF0		= 82600.0 nM\|= 46200.0 nM\|= 75400.0 nM			NPASS
Muscleblind-like protein 1	Homo sapiens	Q9NR56			0.250000 nM\|= 0.25 nM		BindingDB, NPASS
PC4 and SFRS1-interacting protein	Homo sapiens	O75475		1140 nM\|757.81 nM			BindingDB
Neuraminidase	InflueA virus (strain A/Puerto Rico/8/1934 H1N1)	P03468		81700 nM\|82600 nM			BindingDB
Nonstructural protein 3	Zika virus			1300 nM\|22000 nM		800 nM	BindingDB
PI3-kinase p110-gamma subunit	Homo sapiens	P48736		= 4720.0 nM			NPASS
Pancreatic lipase	Homo sapiens	P16233		= 1340.0 nM			NPASS
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens	P48736		1800 nM\|4720 nM	170 nM		BindingDB
Plasmodium falciparum	Plasmodium falciparum			= 57300.0 nM\|= 12900.0 nM\|= 10000.0 nM\|= 3981.07 nM\|= 6309.57 nM\|= 12589.25 nM			NPASS
Monoamine oxidase A	Homo sapiens	P21397		= 9930.0 nM			NPASS
Neuraminidase	InflueA virus (A/WSN/1933(H1N1))	P03470		75400 nM\|82600 nM\|46200 nM			BindingDB
Mitogen-activated protein kinase 14	Homo sapiens	Q16539		1.64e+3 nM			BindingDB
L929	Mus musculus		= 55000.0 nM\|= 59000.0 nM				NPASS
Microtubule-associated protein tau	Homo sapiens	P10636		<3000 nM\|1200 nM\|= 1200.0 nM\|< 3000.0 nM			BindingDB, NPASS
Inositol polyphosphate multikinase	Homo sapiens	Q8NFU5		1100 nM\|= 1100.0 nM			BindingDB, NPASS
Insulin receptor	Homo sapiens	P06213				2600 nM\|= 2600.0 nM	BindingDB, NPASS
Insulin-degrading enzyme	Homo sapiens	P14735		100000 nM\|= 100000.0 nM			BindingDB, NPASS
Interstitial collagenase [100-268]	Human	P03956		2.92e+3 nM			BindingDB
Intestinal alkaline phosphatase	Homo sapiens	P09923	> 100000.0 nM				NPASS
Intestinal alkaline phosphatase	Mus musculus	P24822		= 12500.0 nM			NPASS
Intestinal-type alkaline phosphatase	Homo sapiens	P09923	>100000 nM				BindingDB
Intestinal-type alkaline phosphatase 1	Rattus norvegicus	P15693		12500 nM			BindingDB
Mitogen-activated protein kinase 10	Homo sapiens	P53779		2.24e+3 nM			BindingDB
L02	Homo sapiens			> 20000.0 nM			NPASS
Lactoylglutathione lyase	Homo sapiens	Q04760		560 nM\|3380 nM			BindingDB
Leishmania donovani	Leishmadonovani			= 4080.0 nM			NPASS
Liver microsomes	Rattus norvegicus			= 10500000.0 nM			NPASS
Lymphocyte differentiation antigen CD38	Homo sapiens	P28907		= 24800.0 nM			NPASS
Lysine-specific demethylase 4D-like	Homo sapiens	B2RXH2		= 3000.0 nM			NPASS
Lysine-specific demethylase 4E	Homo sapiens	B2RXH2		3000 nM			BindingDB
MCF7	Homo sapiens			= 4700.0 ug.mL-1\|> 20000.0 nM			NPASS
MO15-related protein kinase Pfmrk	Plasmodium falciparum			157000 nM			BindingDB
Polyphenol oxidase 2	Agaricus bisporus	O42713		210000 nM			BindingDB
Probable DNA dC->dU-editing enzyme APOBEC-3A	Homo sapiens	P31941		= 17500.0 nM			NPASS
Replicase polyprotein 1ab	2019-nCoV	P0DTD1		220 nM\|260 nM			BindingDB
Proteasome subunit beta type-5	Homo sapiens	P28074		12000 nM\|10000 nM			BindingDB
Solute carrier family 2, facilitated glucose transporter member 2	Homo sapiens	P11168		= 12000.0 nM			NPASS
Solute carrier family 2, facilitated glucose transporter member 4	Rattus norvegicus	P19357				= 33500.0 nM	NPASS
Solute carrier organic anion transporter family member 2B1	Homo sapiens	O94956		= 26915.35 nM\|= 26800.0 nM			NPASS
Sortase A	Staphylococcus aureus	Q9S446		= 44030.0 nM			NPASS
Sortase family protein	Staphylococcus aureus			44030 nM			BindingDB
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense			= 49960.0 nM			NPASS
Trypanosoma cruzi	Trypanosoma cruzi			= 94270.0 nM			NPASS
Trypsin I	Bos taurus	P00760		= 10200.0 nM			NPASS
Tyrosinase	Agaricus bisporus	O42713		= 210000.0 nM			NPASS
Tyrosine-protein kinase SYK	Homo sapiens	P43405	54000 nM\|= 54000.0 nM	6400 nM\|= 6400.0 nM			BindingDB, NPASS
Tyrosine-protein kinase receptor FLT3	Homo sapiens	P36888		= 1690.0 nM			NPASS
Tyrosine-protein kinase transforming protein FPS	Fujinami sarcoma virus	P00530				= 1800.0 nM	NPASS
Tyrosine-protein kinase transforming protein Fps	Fujinami sarcoma virus	P00530				1800 nM	BindingDB
Xanthine dehydrogenase	Homo sapiens	P47989		= 2380.0 nM			NPASS
Xanthine dehydrogenase/oxidase	Homo sapiens	P47989		2380 nM			BindingDB
n.a.				> 29904.0 nM			NPASS
Inositol hexakisphosphate kinase 2	Homo sapiens	Q9UHH9		700 nM\|= 700.0 nM			BindingDB, NPASS
Sialidase-2	Homo sapiens	Q9Y3R4		150000 nM			BindingDB
Proteasome Macropain subunit MB1	Homo sapiens	P28074		= 12000.0 nM\|= 10000.0 nM			NPASS
Sialidase 2	Homo sapiens	Q9Y3R4		= 150000.0 nM			NPASS
Serine/threonine-protein kinase pim-1	Homo sapiens	P11309		780 nM\|776 nM			BindingDB
Protein E6	Human papillomavirus type 16	P03126		850 nM\|= 850.0 nM			BindingDB, NPASS
Protein kinase C (PKC)	Rattus norvegicus	P09217		= 7800.0 nM			NPASS
Protein kinase C zeta type	Rattus norvegicus	P09217		7800 nM			BindingDB
Protein kinase Pfmrk	Plasmodium falciparum	P90584		= 157000.0 nM			NPASS
Pyruvate kinase isozymes M1/M2	Homo sapiens	P14618	= 0.51 nM				NPASS
RNase L	Homo sapiens	Q05823		= 264000.0 nM			NPASS
Radical scavenging activity				= 22.0 ug.mL-1			NPASS
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens	P36888		1690 nM			BindingDB
Replicase polyprotein 1ab	Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC)	K9N7C7		> 10000.0 nM			NPASS
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	P0DTD1		200 nM\|= 220.0 nM\|= 400.0 nM\|= 600.0 nM\|= 200.0 nM\|= 2860.0 nM		15730 nM\|= 15730.0 nM	BindingDB, NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2		= 8000.0 nM\|= 900.0 nM	> 20000.0 nM\|> 19952.62 nM			NPASS
SK-BR-3	Homo sapiens			> 100000.0 nM			NPASS
Salivary alpha-amylase	Homo sapiens	P04745		= 30200.0 nM			NPASS
Serine protease 1	Bos taurus	P00760		10200 nM			BindingDB
Serine/threonine-protein kinase 33	Homo sapiens	Q9BYT3	17970 nM				BindingDB
Serine/threonine-protein kinase B-raf	Homo sapiens	P15056		= 1562.0 nM			NPASS
Serine/threonine-protein kinase PIM1	Homo sapiens	P11309		= 780.0 nM			NPASS
Short transient receptor potential channel 5	Homo sapiens	Q9UL62		>10000 nM\|> 10000.0 nM			BindingDB, NPASS
Huntingtin	Homo sapiens	P42858		7110 nM			BindingDB
Integrase	Human immunodeficiency virus 1			2500 nM\|7600 nM\|600 nM\|2000 nM			BindingDB
Human immunodeficiency virus 1	Human immunodeficiency virus 1		< 100000.0 nM\|= 35000.0 nM				NPASS
Angiotensin-converting enzyme 2	Homo sapiens	Q9BYF1		10000 nM\|= 10000.0 nM			BindingDB, NPASS
Anthrax toxin receptor 2	Homo sapiens	P58335		>300000 nM\|> 300000.0 nM			BindingDB, NPASS
Arginase	Leishmaamazonensis			2100 nM		1200 nM	BindingDB
Arginase	Leishmaamazonensis	O96394		= 2100.0 nM		= 1200.0 nM	NPASS
Aromatase	Homo sapiens	P11511		10000 nM			BindingDB
Aurora kinase B	Homo sapiens	Q96GD4		3.98e+3 nM			BindingDB
Beta amyloid A4 protein	Homo sapiens	P05067		< 3000.0 nM\|= 15100.0 nM			NPASS
Beta-secretase 1	Homo sapiens	P56817		2800 nM\|4180 nM\|= 2800.0 nM\|= 4180.0 nM			BindingDB, NPASS
Butyrylcholinesterase	Homo sapiens	P06276				= 71000.0 nM	NPASS
CWR22R	Homo sapiens			= 13100.0 nM			NPASS
Canalicular multispecific organic anion transporter 1	Homo sapiens	Q92887		= 22000.0 nM			NPASS
Candida albicans	Candida albicans			> 50.0 ug.mL-1			NPASS
Casein kinase 2	Homo sapiens			= 900.0 nM			NPASS
Casein kinase 2	Rattus norvegicus			= 920.0 nM			NPASS
Casein kinase II	Homo sapiens	P19784		= 920.0 nM\|< 1000.0 nM			NPASS
Casein kinase II subunit alpha 3	Homo sapiens	Q8NEV1		900 nM			BindingDB
Cell division protein kinase 5	Rattus norvegicus	Q03114	= 71100.0 nM				NPASS
Amyloid-beta precursor protein	Homo sapiens	P05067		1.51e+4 nM\|15100 nM\|14800 nM\|4100 nM\|7400 nM\|9900 nM			BindingDB
Cholinesterase	Homo sapiens	P06276				71000 nM	BindingDB
Amyloid-beta A4 protein	Homo sapiens	P05067		= 9900.0 nM			NPASS
Alpha-glucosidase MAL62	Saccharomyces cerevisiae	P07265		5000 nM			BindingDB
1-deoxy-D-xylulose 5-phosphate reductoisomerase	Escherichia coli (strain K12)	P45568		1.5e+3 nM			BindingDB
17-beta-hydroxysteroid dehydrogenase type 3	Homo sapiens	P37058		1.005e+5 nM			BindingDB
2-5A-dependent ribonuclease	Homo sapiens	Q05823		264000 nM			BindingDB
3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum			14000 nM			BindingDB
3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum	Q965D6		= 14000.0 nM			NPASS
A549	Homo sapiens			= 14800.0 ug.mL-1			NPASS
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	Homo sapiens	P28907		24800 nM			BindingDB
ATP-binding cassette sub-family C member 2	Homo sapiens	Q92887		22000 nM			BindingDB
Acetylcholinesterase	Homo sapiens	P22303		12 nM\|= 12.0 nM		37800 nM\|= 37800.0 nM	BindingDB, NPASS
Acid phosphatase	Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)					1.54e+5 nM	BindingDB
Aldo-keto reductase family 1 member B1	Homo sapiens	P15121		29000 nM			BindingDB
Aldo-keto reductase family 1 member C21	Mus musculus	Q91WR5		12300 nM\|= 12300.0 nM			BindingDB, NPASS
Aldose reductase	Homo sapiens	P15121		= 29000.0 nM			NPASS
Alkaline phosphatase placental-like	Homo sapiens	P10696	= 32300.0 nM				NPASS
Alkaline phosphatase, germ cell type	Homo sapiens	P10696	32300 nM				BindingDB
Alkaline phosphatase, tissue-nonspecific isozyme	Homo sapiens	P05186		33200 nM\|= 33200.0 nM			BindingDB, NPASS
Alpha-amylase 1A	Homo sapiens	P0DUB6		30200 nM			BindingDB
Alpha-synuclein	Homo sapiens	P37840		13300 nM\|220 nM\|= 13300.0 nM\|= 220.0 nM			BindingDB, NPASS
Cyclin-dependent kinase 5	Rattus norvegicus	Q03114	71100 nM				BindingDB
3-hydroxyacyl-[acyl-carrier-protein] dehydratase	Plasmodium falciparum			2000 nM			BindingDB
Cytochrome P450 19A1	Homo sapiens	P11511		= 10000.0 nM			NPASS
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum	Q965D5		= 400.0 nM			NPASS
Entamoeba histolytica	Eoeba histolytica			= 115.21 ug.mL-1			NPASS
Escherichia coli	Escherichia coli			= 0.88 ug.mL-1			NPASS
Fatty acid synthase	Plasmodium falciparum	Q965D7		= 2000.0 nM			NPASS
Filobasidiella neoformans	Cryptococcus neoformans			> 50.0 ug.mL-1			NPASS
G-protein coupled receptor 35	Homo sapiens	Q9HC97	3020 nM\|14700 nM\|= 3020.0 nM\|= 14700.0 nM	2120 nM\|= 2120.0 nM			BindingDB, NPASS
Genome polyprotein	Zika virus	A0A024AXB9		= 22000.0 nM\|= 1300.0 nM		= 800.0 nM	NPASS
Glyoxalase I	Homo sapiens	Q04760		= 560.0 nM\|= 3380.0 nM			NPASS
H9	Homo sapiens			= 69000.0 nM			NPASS
HCT-116	Homo sapiens			= 24000.0 nM\|= 23000.0 nM\|= 4100.0 nM\|= 28200.0 nM\|> 20000.0 nM			NPASS
HK-2	Homo sapiens			> 20000.0 nM			NPASS
HT-29	Homo sapiens			> 20000.0 nM			NPASS
Heat shock protein HSP 90-beta	Homo sapiens	P08238		13500 nM\|= 13500.0 nM			BindingDB, NPASS
HepG2	Homo sapiens			> 20000.0 nM			NPASS
Hepatitis C virus	Hepatitis C virus		= 46900.0 nM				NPASS
Histone deacetylase 6	Homo sapiens	Q9UBN7		= 1562.0 nM			NPASS
Cystathionine beta-synthase	Homo sapiens	P35520		= 18800.0 nM			NPASS
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum			400 nM			BindingDB
ELAV-like protein 3	Homo sapiens	Q14576		1000 nM\|= 1000.0 nM			BindingDB, NPASS
Human immunodeficiency virus type 1 integrase	Human immunodeficiency virus 1	Q7ZJM1		= 2000.0 nM\|= 600.0 nM\|= 7600.0 nM\|= 2500.0 nM			NPASS
Dihydroorotate dehydrogenase (fumarate)	Leishmamajor	Q4QEW7		= 29910.0 nM\|= 31622.78 nM			NPASS
Cytochrome P450 1B1	Homo sapiens	Q16678				27 nM\|= 27.0 nM	BindingDB, NPASS
DNA dC->dU-editing enzyme APOBEC-3A	Homo sapiens	P31941		17500 nM			BindingDB
DNA dC->dU-editing enzyme APOBEC-3G	Homo sapiens	Q9HC16		2390 nM\|= 2390.0 nM			BindingDB, NPASS
Dipeptidyl peptidase IV	Homo sapiens	P27487		= 37150.0 nM			NPASS
DNA gyrase	Escherichia coli K-12	P0AES4		= 225.0 ug.mL-1			NPASS
Cytochrome P450 1A1	Homo sapiens	P04798				370 nM\|= 370.0 nM	BindingDB, NPASS
DNA gyrase A/A/B/B tetramer	Escherichia coli (strain K12)	P0AES4\|P0AES6		707000 nM			BindingDB
DNA ligase 1	Homo sapiens	P18858		87900 nM\|= 28.0 ug.mL-1			BindingDB, NPASS
DNA primase TraC	Escherichia coli	P27189		700000 nM			BindingDB
DNA primase traC	Escherichia coli	P27189		= 700000.0 nM			NPASS
DNA topoisomerase 1	Homo sapiens	P11387		37300 nM			BindingDB
DNA topoisomerase 2-alpha	Homo sapiens	P11388		37700 nM\|390 nM\|37300 nM			BindingDB
DNA topoisomerase I	Homo sapiens	P11387		= 11.9 ug.mL-1			NPASS
DNA topoisomerase II alpha	Homo sapiens	P11388		= 11.9 ug.mL-1\|= 390.0 nM			NPASS
DNA-(apurinic or apyrimidinic site) endonuclease	Homo sapiens	P27695		320 nM			BindingDB
DNA-(apurinic or apyrimidinic site) lyase	Homo sapiens	P27695		= 320.0 nM			NPASS
Death-associated protein kinase 1	Homo sapiens	P53355		23000 nM\|= 23000.0 nM			BindingDB, NPASS
Dengue virus type 2 NS3 protein	Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)	P29990		= 8460.0 nM			NPASS
Dihydroorotate dehydrogenase (fumarate)	Leishmamajor			31623 nM\|29910 nM			BindingDB

a curated database

IMPPAT Phytochemical information:
Myricetin

Bioactivity information

IMPPAT Phytochemical information: Myricetin

Bioactivity information

IMPPAT Phytochemical information:
Myricetin