IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Peroxisome proliferator-activated receptor alpha	Homo sapiens	Q07869	41310 nM\|= 41310.0 nM				BindingDB, NPASS
Phospholipase A2	Echis carinatus	Q7T3S7		= 2300.0 nM			NPASS
Phospholipase A2 isozyme DE-I	Naja melanoleuca	P00599		= 2900.0 nM			NPASS
Phospholipase A2 isozyme PLA-A	Trimeresurus flavoviridis	P59264		= 2500.0 nM			NPASS
Plasmodium falciparum	Plasmodium falciparum			= 52930.0 nM\|> 40000.0 nM\|= 50640.0 nM			NPASS
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens	P09917		>40000 nM			BindingDB
Prostaglandin G/H synthase 1	Ovis aries	P05979		>40000 nM			BindingDB
Prostaglandin G/H synthase 1	Homo sapiens	P23219		210000 nM			BindingDB
Pancreatic alpha-amylase	Sus scrofa	P00690		22600 nM\|= 22600.0 nM			BindingDB, NPASS
Prostaglandin G/H synthase 2	Homo sapiens	P35354		86000 nM\|130000 nM\|>40000 nM			BindingDB
Protease	Human immunodeficiency virus 1			8000 nM\|4000 nM\|6000 nM			BindingDB
Protease	Human immunodeficiency virus 1	Q9YQ12		= 8000.0 nM			NPASS
Protein-tyrosine phosphatase 1B	Homo sapiens	P18031		= 3600.0 nM\|= 3100.0 nM\|= 3080.0 nM\|= 3800.0 nM\|= 3900.0 nM\|= 2500.0 nM\|= 3400.0 nM\|= 2300.0 nM\|= 2750.0 nM\|= 4120.0 nM\|= 4000.0 nM\|= 3500.0 nM\|= 15500.0 nM\|= 5200.0 nM\|= 8900.0 nM\|= 5400.0 nM\|= 5460.0 nM\|= 22200.0 nM\|= 5000.0 nM\|= 5100.0 nM\|= 27800.0 nM\|= 33100.0 nM\|= 30700.0 nM\|= 26600.0 nM		= 3400.0 nM\|= 6400.0 nM	NPASS
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens	O15296		>40000 nM			BindingDB
PC-3	Homo sapiens			= 22300.0 nM\|> 10.0 ug.mL-1\|= 20800.0 nM			NPASS
OVCAR-3	Homo sapiens			= 12.9 ug.mL-1			NPASS
Ovis aries	Ovis aries			= 54700.0 nM			NPASS
Lysosomal alpha-glucosidase	Homo sapiens	P10253		9670 nM\|= 4.42 ug.mL-1			BindingDB, NPASS
MCF7	Homo sapiens		= 12700.0 nM	> 30000.0 nM\|= 12300.0 nM\|= 37000.0 nM\|= 44840.0 nM\|= 6600.0 nM\|= 9300.0 nM\|= 70120.0 nM			NPASS
MDA-MB-231	Homo sapiens			> 30000.0 nM\|> 40000.0 nM\|= 5900.0 nM\|= 70270.0 nM			NPASS
MDA-MB-435	Homo sapiens			= 13.1 ug.mL-1			NPASS
MGC-803	Homo sapiens			= 24320.0 nM\|= 27080.0 nM\|= 27580.0 nM\|> 200000.0 nM			NPASS
MIA PaCa-2	Homo sapiens			= 10400.0 nM			NPASS
NCI-H460	Homo sapiens			= 32170.0 nM\|= 16200.0 nM			NPASS
NCI-N87	Homo sapiens			= 4200.0 nM			NPASS
NIH3T3	Mus musculus		= 18700.0 nM\|= 13100.0 nM				NPASS
NON-PROTEIN TARGET			= 14700.0 nM	> 20000.0 nM\|= 145000.0 nM\|= 29440.0 nM\|= 34.53 ug.mL-1\|> 50.0 ug.mL-1\|= 0.29 ug.mL-1\|= 0.31 ug.mL-1\|= 2.79 ug.mL-1\|= 5.21 ug.mL-1\|= 38780.0 nM\|= 29290.0 nM\|= 42000.0 nM\|= 9100.0 nM\|= 14800.0 nM\|= 15300.0 nM\|= 21100.0 nM\|= 30800.0 nM\|= 18200.0 nM			NPASS
Neutrophil elastase	Homo sapiens	P08246		416 nM			BindingDB
No relevant target				= 59.0 ug.mL-1\|= 5970.0 ug.mL-1			NPASS
Nuclear factor NF-kappa-B p65 subunit	Homo sapiens	Q04206		= 31.0 nM			NPASS
Nuclear receptor ROR-gamma	Homo sapiens	P51449		130 nM\|1060 nM\|9410 nM\|= 680.0 nM\|= 130.0 nM\|= 1060.0 nM\|= 9410.0 nM\|= 0.75 nM			BindingDB, NPASS
Protein-tyrosine phosphatase 1C	Homo sapiens	P29350		= 25780.0 nM			NPASS
PANC-1	Homo sapiens			= 14900.0 nM\|= 58030.0 nM			NPASS
RAW264.7	Mus musculus			= 46900.0 nM\|= 58500.0 nM\|> 50000.0 nM\|= 13800.0 nM			NPASS
Receptor-type tyrosine-protein phosphatase alpha	Homo sapiens	P18433		>40000 nM\|> 40000.0 nM			BindingDB, NPASS
Receptor-type tyrosine-protein phosphatase F (LAR)	Homo sapiens	P10586		> 40000.0 nM\|= 3800.0 nM			NPASS
Toxoplasma gondii	Toxoplasma gondii			= 1000.0 nM\|= 5900.0 nM			NPASS
Transcription factor p65	Homo sapiens	Q04206		31 nM			BindingDB
Trichomonas vaginalis	Trichomonas vaginalis			= 35300.0 nM			NPASS
Trypanosoma brucei	Trypanosoma brucei			= 4000.0 nM			NPASS
Trypanosoma brucei brucei	Trypanosoma brucei brucei			= 2200.0 nM			NPASS
Trypanosoma cruzi	Trypanosoma cruzi			= 4000.0 nM			NPASS
THP-1	Homo sapiens			= 9100.0 nM			NPASS
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens	P18031		4.5e+3 nM\|9430 nM\|4000 nM\|3500 nM\|3400 nM\|3080 nM\|15500 nM\|5200 nM\|2500 nM\|3100 nM\|3600 nM\|8900 nM\|5400 nM\|4120 nM\|5460 nM\|3900 nM\|3800 nM\|2300 nM\|2750 nM\|22200 nM\|5000 nM\|5100 nM\|27800 nM\|33100 nM		6400 nM\|3400 nM	BindingDB
Tyrosine-protein phosphatase non-receptor type 6	Homo sapiens	P29350		25780 nM			BindingDB
Ubiquitin carboxyl-terminal hydrolase 47	Homo sapiens	Q96K76		26000 nM\|= 26000.0 nM			BindingDB, NPASS
Ubiquitin carboxyl-terminal hydrolase 7	Homo sapiens	Q93009		7000 nM\|= 7000.0 nM			BindingDB, NPASS
WI-38 VA13	Homo sapiens			= 93600.0 nM			NPASS
Z-138	Homo sapiens			= 9800.0 nM			NPASS
Lu1	Homo sapiens			= 11500.0 nM			NPASS
Tyrosine-protein phosphatase non-receptor type 2	Homo sapiens	P17706		3330 nM\|6700 nM\|2400 nM			BindingDB
Receptor-type tyrosine-protein phosphatase F	Homo sapiens	P10586		>40000 nM\|3800 nM			BindingDB
T-cell protein-tyrosine phosphatase	Homo sapiens	P17706		= 3330.0 nM\|= 6700.0 nM\|= 2400.0 nM			NPASS
Sucrase-isomaltase, intestinal	Rattus norvegicus	P23739		>1000000 nM			BindingDB
Receptor-type tyrosine-protein phosphatase epsilon	Homo sapiens	P23469		>40000 nM\|> 40000.0 nM			BindingDB, NPASS
SGC-7901	Homo sapiens			> 20000.0 nM			NPASS
SH-SY5Y	Homo sapiens			= 54620.0 nM			NPASS
SK-OV-3	Homo sapiens			> 10000.0 nM			NPASS
SMMC-7721	Homo sapiens			> 40000.0 nM			NPASS
Sentrin-specific protease 1	Homo sapiens	Q9P0U3		6.4 nM\|= 6.4 nM\|= 2600.0 nM\|= 2580.0 nM			BindingDB, NPASS
T-24	Homo sapiens			= 29290.0 nM\|= 17760.0 nM			NPASS
Solute carrier organic anion transporter family member 1B1	Homo sapiens	Q9Y6L6		15849 nM\|= 15848.93 nM			BindingDB, NPASS
Steryl-sulfatase	Homo sapiens	P08842		= 0.12 ug.mL-1			NPASS
Steryl-sulfatase	Rattus norvegicus	P15589		= 0.06 ug.mL-1			NPASS
Streptococcus	Streptococcus		= 880.0 nM				NPASS
Streptococcus sp. 'group A'	Streptococcus sp. 'group A'		= 949.0 nM				NPASS
Streptokinase A	Streptococcus pyogenes serotype M1	P10520	= 1790.0 nM				NPASS
Sucrase-isomaltase	Rattus norvegicus	P23739		> 1000000.0 nM			NPASS
Solute carrier organic anion transporter family member 1B3	Homo sapiens	Q9NPD5		11482 nM\|= 11481.54 nM			BindingDB, NPASS
Low molecular weight phosphotyrosine protein phosphatase	Homo sapiens	P24666		7200 nM\|11100 nM\|= 11100.0 nM\|= 7200.0 nM			BindingDB, NPASS
Aromatase	Homo sapiens	P11511		32000 nM			BindingDB
LN-229	Homo sapiens			= 47400.0 nM			NPASS
B16-F10	Mus musculus			= 20080.0 nM			NPASS
BGC-823	Homo sapiens			> 10000.0 nM\|= 66380.0 nM\|= 22960.0 nM			NPASS
Basic phospholipase A2 1	Naja melanoleuca	P00599		2900 nM			BindingDB
Basic phospholipase A2 PLA-A	Protobothrops flavoviridis	P59264		2500 nM			BindingDB
Bcap37	Homo sapiens			= 28690.0 nM			NPASS
Bel-7402	Homo sapiens			= 64640.0 nM			NPASS
B16	Mus musculus			= 3100.0 nM			NPASS
Bile acid receptor FXR	Homo sapiens	Q96RI1	= 0.0 nM				NPASS
Ca9-22	Homo sapiens			= 5.9 ug.mL-1			NPASS
Candida albicans	Candida albicans			> 50.0 ug.mL-1			NPASS
Cathepsin D	Homo sapiens	P07339		18200 nM\|= 18200.0 nM			BindingDB, NPASS
Cholesteryl ester transfer protein	Homo sapiens	P11597		46600 nM\|>50000 nM\|= 46600.0 nM\|> 50000.0 nM			BindingDB, NPASS
Cyclooxygenase-1	Homo sapiens	P23219		= 210000.0 nM			NPASS
Cyclooxygenase-1	Ovis aries	P05979		> 40000.0 nM			NPASS
CAPAN-1	Homo sapiens			= 8600.0 nM			NPASS
Cyclooxygenase-2	Homo sapiens	P35354		= 86000.0 nM\|= 130000.0 nM\|> 40000.0 nM			NPASS
Arachidonate 5-lipoxygenase	Homo sapiens	P09917		> 40000.0 nM			NPASS
Aldose reductase	Homo sapiens	P15121		= 41000.0 nM			NPASS
Liver carboxylesterase 1	Homo sapiens	P23141		100 nM			BindingDB
11-beta-hydroxysteroid dehydrogenase 1	Homo sapiens	P28845		1900 nM\|= 1900.0 nM			BindingDB, NPASS
4T1	Mus musculus			= 44080.0 nM			NPASS
518A2	Homo sapiens		= 14700.0 nM				NPASS
8505C	Homo sapiens		= 13500.0 nM				NPASS
A-375	Homo sapiens			= 30880.0 nM			NPASS
Arachidonate 15-lipoxygenase, type II	Homo sapiens	O15296		> 40000.0 nM			NPASS
A2780	Homo sapiens		= 11700.0 nM	>= 20.0 ug.mL-1\|= 9.2 ug.mL-1			NPASS
AGS	Homo sapiens			= 20600.0 nM\|= 43300.0 nM			NPASS
ASPC1	Homo sapiens			= 12600.0 nM			NPASS
Acidic phospholipase A2 EC-I	Echis carinatus	Q7T3S7		2300 nM			BindingDB
Acyl coenzyme A:cholesterol acyltransferase	Homo sapiens	P23141		= 100.0 nM			NPASS
Aldo-keto reductase family 1 member B1	Homo sapiens	P15121		41000 nM			BindingDB
Aldo-keto reductase family 1 member B10	Homo sapiens	O60218		4000 nM\|= 4000.0 nM		2000 nM\|= 6000.0 nM\|= 3700.0 nM\|= 2100.0 nM\|= 2800.0 nM\|= 2000.0 nM	BindingDB, NPASS
A549	Homo sapiens		= 15500.0 nM	= 21600.0 nM\|= 55800.0 nM\|= 11400.0 nM\|= 33000.0 nM\|= 35790.0 nM\|= 74650.0 nM\|= 18420.0 nM\|= 77650.0 nM			NPASS
Cytochrome P450 19A1	Homo sapiens	P11511		= 32000.0 nM\|= 14.0 ug.mL-1			NPASS
Caenorhabditis elegans	Caenorhabditis elegans			= 50000.0 nM			NPASS
DNA polymerase beta	Homo sapiens	P06746		18600 nM\|= 18600.0 nM			BindingDB, NPASS
Hemagglutinin	InflueA virus (strain A/Puerto Rico/8/1934 H1N1)	P03452			46500 nM		BindingDB
Hep 3B2	Homo sapiens			= 23800.0 nM			NPASS
HepG2	Homo sapiens			= 68820.0 nM\|= 53400.0 nM\|= 15000.0 nM\|= 53420.0 nM\|= 42900.0 nM\|= 30210.0 nM\|> 10000.0 nM\|= 40200.0 nM\|= 68800.0 nM\|= 14490.0 nM\|> 20000.0 nM			NPASS
Hepatitis B virus	Hepatitis B virus			= 896700.0 nM\|= 1357100.0 nM			NPASS
DNA ligase 1	Homo sapiens	P18858		262000 nM\|= 120.0 ug.mL-1			BindingDB, NPASS
Histidine-rich protein PFHRP-II	Plasmodium falciparum	P05227		>20000000 nM			BindingDB
Human immunodeficiency virus 1	Human immunodeficiency virus 1		= 10.0 nM	= 14300.0 nM\|= 6.5 ug.mL-1\|= 14700.0 nM\|= 14400.0 nM			NPASS
Hypoxia-inducible factor 1 alpha	Homo sapiens	Q16665		> 100000.0 nM			NPASS
Hypoxia-inducible factor 1-alpha	Homo sapiens	Q16665		>100000 nM			BindingDB
Hypoxia-inducible factor prolyl hydroxylase	Homo sapiens		> 50000.0 nM				NPASS
J774	Mus musculus			= 13100.0 nM			NPASS
K562	Homo sapiens			= 41010.0 nM\|= 10200.0 nM			NPASS
K562/Adr	Homo sapiens			= 38060.0 nM			NPASS
KB	Homo sapiens			= 31500.0 nM\|= 31800.0 nM			NPASS
L02	Homo sapiens			> 50000.0 nM\|= 58370.0 nM\|= 8850.0 nM			NPASS
Hemagglutinin	InflueA virus (A/Puerto Rico/8/1934(H1N1))	P03452			= 46500.0 nM		NPASS
HeLa	Homo sapiens			> 10000.0 nM\|= 33120.0 nM\|= 64480.0 nM\|> 40000.0 nM\|= 11.1 ug.mL-1\|= 33100.0 nM			NPASS
Histidine-rich protein	Plasmodium falciparum	P05227		> 20000000.0 nM			NPASS
HT-29	Homo sapiens		= 10600.0 nM	= 25300.0 nM\|= 26310.0 nM\|= 11.1 ug.mL-1\|= 3500.0 nM			NPASS
DU-145	Homo sapiens			= 11.1 ug.mL-1			NPASS
Egl nine homolog 1/Prolyl hydroxylase EGLN2/Prolyl hydroxylase EGLN3/Transmembrane prolyl 4-hydroxylase	Homo sapiens	Q96KS0\|Q9GZT9\|Q9H6Z9\|Q9NXG6	>50000 nM				BindingDB
Env polyprotein	Human immunodeficiency virus 1		>100000 nM				BindingDB
FaDu	Homo sapiens		= 14200.0 nM				NPASS
Fatty acid synthase	Gallus gallus	P12276		59300 nM\|13100 nM\|= 59300.0 nM\|= 13100.0 nM			BindingDB, NPASS
Filobasidiella neoformans	Cryptococcus neoformans			> 50.0 ug.mL-1			NPASS
DNA polymerase beta	Rattus norvegicus	P06766		8500 nM\|4800 nM\|= 8500.0 nM\|= 4800.0 nM			BindingDB, NPASS
GP41	Human immunodeficiency virus 1	Q76270	> 100000.0 nM				NPASS
Glycogen phosphorylase, muscle form	Oryctolagus cuniculus	P00489		15300 nM\|9000 nM\|= 9000.0 nM\|= 15300.0 nM\|= 8912.51 nM			BindingDB, NPASS
H9	Homo sapiens		= 2.0 ug.mL-1\|= 4400.0 nM				NPASS
HCT-116	Homo sapiens			= 42000.0 nM\|= 19000.0 nM\|= 17700.0 nM			NPASS
HL-60	Homo sapiens			= 21000.0 nM\|= 8.7 ug.mL-1\|> 40000.0 nM\|= 9500.0 nM			NPASS
HMEC	Homo sapiens			= 39300.0 nM			NPASS
G-protein coupled bile acid receptor 1	Homo sapiens	Q8TDU6	1430 nM\|= 1430.0 nM				BindingDB, NPASS

a curated database

IMPPAT Phytochemical information:
Ursolic acid

Bioactivity information

IMPPAT Phytochemical information: Ursolic acid

Bioactivity information

IMPPAT Phytochemical information:
Ursolic acid