IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
NCI/ADR-RES	Homo sapiens			= 200.0 nM			NPASS
NADPH oxidase 4	Homo sapiens	Q9NPH5		1130 nM\|= 1130.0 nM			BindingDB, NPASS
NACHT, LRR and PYD domains-containing protein 3	Homo sapiens	Q96P20		10000 nM\|= 10000.0 nM			BindingDB, NPASS
Multidrug resistance-associated protein 1	Homo sapiens	P33527				2400 nM\|4900 nM\|= 2400.0 nM\|= 4900.0 nM	BindingDB, NPASS
Myeloperoxidase	Homo sapiens	P05164		3800 nM\|= 3800.0 nM			BindingDB, NPASS
Mus musculus	Mus musculus			= 10700.0 nM\|> 30000.0 nM			NPASS
Monoamine oxidase B	Homo sapiens	P27338		= 12800.0 nM\|= 1120.0 nM			NPASS
NON-PROTEIN TARGET			= 31600.0 nM\|= 25000.0 nM\|= 24500.0 nM	> 100.0 ug.mL-1\|> 100000.0 nM\|= 1330.0 nM\|= 141400.0 nM\|= 88240.0 nM\|= 81270.0 nM\|= 18600.0 nM			NPASS
Myocilin	Homo sapiens	Q99972			41600 nM\|= 41600.0 nM		BindingDB, NPASS
Neuraminidase	InflueA virus	B4URF0		= 31600.0 nM\|= 28900.0 nM\|= 45700.0 nM\|= 33400.0 nM		= 37100.0 nM	NPASS
Plasmodium falciparum	Plasmodium falciparum			= 17400.0 nM\|= 10000.0 nM\|= 15848.93 nM\|= 12589.25 nM			NPASS
Neuraminidase	InflueA virus (A/WSN/1933(H1N1))	P03470		31600 nM\|28900 nM\|45700 nM			BindingDB
Neuraminidase	InflueA virus (strain A/Puerto Rico/8/1934 H1N1)	P03468		31600 nM\|31400 nM			BindingDB
Neutrophil elastase	Homo sapiens	P08246		46100 nM		49900 nM	BindingDB
No relevant target				= 2760690.0 nM\|= 18200.0 nM\|= 68850.0 nM			NPASS
P-glycoprotein 1	Homo sapiens	P08183	> 10000.0 nM		= 10000.0 nM		NPASS
Peroxisome proliferator-activated receptor gamma	Mus musculus	P37238	24900 nM\|= 24900.0 nM				BindingDB, NPASS
Monoamine oxidase A	Homo sapiens	P21397		= 1700.0 nM\|= 640.0 nM\|= 1550.0 nM			NPASS
Poly [ADP-ribose] polymerase 1	Homo sapiens	P09874		100000 nM			BindingDB
Poly [ADP-ribose] polymerase tankyrase-1	Homo sapiens	O95271		3100 nM			BindingDB
Poly [ADP-ribose] polymerase tankyrase-2	Homo sapiens	Q9H2K2		2900 nM			BindingDB
Neuraminidase	InflueA virus (A/Puerto Rico/8/1934(H1N1))	P03468		= 8.54 ug.mL-1			NPASS
Mitogen-activated protein kinase 14	Homo sapiens	Q16539		1.43e+4 nM			BindingDB
Lysozyme C	Rattus norvegicus	P00697		= 17700.0 nM			NPASS
MO15-related protein kinase Pfmrk	Plasmodium falciparum			7000 nM			BindingDB
Human immunodeficiency virus 1	Human immunodeficiency virus 1		>= 100000.0 nM\|= 9000.0 nM\|= 4.46 ug.mL-1				NPASS
Human immunodeficiency virus type 1 integrase	Human immunodeficiency virus 1	Q7ZJM1		> 20000.0 nM\|= 1500.0 nM			NPASS
Human immunodeficiency virus type 1 reverse transcriptase	Human immunodeficiency virus 1	Q72547		= 443000.0 nM			NPASS
Influenza A virus	InflueA virus		= 42700.0 nM	= 4740.0 nM			NPASS
Influenza A virus (A/PR/8/34(H1N1))	InflueA virus (A/Puerto Rico/8/1934(H1N1))		= 60400.0 nM				NPASS
Inositol hexakisphosphate kinase 2	Homo sapiens	Q9UHH9		7100 nM\|= 7100.0 nM			BindingDB, NPASS
Inositol polyphosphate multikinase	Homo sapiens	Q8NFU5		29000 nM\|= 29000.0 nM			BindingDB, NPASS
Integrase	Human immunodeficiency virus 1			1500 nM\|>20000 nM			BindingDB
Jurkat	Homo sapiens			= 30.0 ug.mL-1\|= 6.7 ug.mL-1			NPASS
L6	Rattus norvegicus			= 18.1 ug.mL-1			NPASS
Mitogen-activated protein kinase 10	Homo sapiens	P53779		2.2e+3 nM			BindingDB
Lactoperoxidase	Bos taurus	P80025		17800 nM\|= 17800.0 nM			BindingDB, NPASS
Leishmania donovani	Leishmadonovani			= 32000.0 nM\|= 43000.0 nM\|= 1.9 ug.mL-1			NPASS
Leishmania enriettii	Leishmaenriettii			= 55000.0 nM			NPASS
Leukocyte elastase	Homo sapiens	P08246		= 46100.0 nM		= 49900.0 nM	NPASS
Liver microsomes	Rattus norvegicus			= 100000000.0 nM			NPASS
Poly [ADP-ribose] polymerase-1	Homo sapiens	P09874		= 100000.0 nM			NPASS
Lysozyme C-1	Rattus norvegicus	P00697		17700 nM			BindingDB
Xanthine dehydrogenase/oxidase	Homo sapiens	P47989		3200 nM\|700 nM		520 nM	BindingDB
MAP kinase signal-integrating kinase 2	Homo sapiens	Q9HBH9		= 308.0 nM			NPASS
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens	Q9HBH9		308 nM			BindingDB
MCF7	Homo sapiens			= 95000.0 nM\|> 100000.0 nM\|= 1000.0 nM			NPASS
Leishmania amazonensis	Leishmaamazonensis		= 3850.0 nM\|= 2990.0 nM\|= 1430.0 nM\|= 730.0 nM\|= 160.0 nM	= 63000.0 nM\|= 31400.0 nM\|= 23700.0 nM			NPASS
Polyphenol oxidase 2	Agaricus bisporus	O42713		305000 nM			BindingDB
RAW264.7	Mus musculus			= 500.0 nM\|= 6700.0 nM\|= 7700.0 nM\|= 14000.0 nM\|= 13400.0 nM\|= 18400.0 nM			NPASS
Prostaglandin G/H synthase 2	Homo sapiens	P35354		8000 nM			BindingDB
Solute carrier organic anion transporter family member 2B1	Homo sapiens	O94956		= 18197.01 nM\|= 18100.0 nM			NPASS
THP-1	Homo sapiens			= 60000.0 nM			NPASS
Tankyrase-1	Homo sapiens	O95271		= 3162.28 nM\|= 3100.0 nM			NPASS
Tankyrase-2	Homo sapiens	Q9H2K2		= 2951.21 nM\|= 2900.0 nM			NPASS
Transthyretin	Homo sapiens	P02766		653 nM\|18000 nM\|= 653 nM\|= 18000.0 nM\|= 653.0 nM	250 nM\|= 250.0 nM		BindingDB, NPASS
Transthyretin	Human	P02766		653 nM			BindingDB
Trypanosoma brucei brucei	Trypanosoma brucei brucei			= 11900.0 nM			NPASS
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense			= 5.1 ug.mL-1			NPASS
Trypanosoma cruzi	Trypanosoma cruzi			= 680000.0 nM\|= 21.8 ug.mL-1			NPASS
Trypsin I	Bos taurus	P00760		= 141500.0 nM			NPASS
Solute carrier family 22 member 2	Homo sapiens	O15244		= 30860.0 nM			NPASS
Tyrosinase	Agaricus bisporus	O42713		= 305000.0 nM			NPASS
Tyrosine-protein kinase Lck	Homo sapiens	P06239		14800 nM			BindingDB
Tyrosine-protein kinase SYK	Homo sapiens	P43405	3000 nM\|= 3000.0 nM	4200 nM\|= 4200.0 nM			BindingDB, NPASS
Tyrosine-protein kinase receptor FLT3	Homo sapiens	P36888		= 1450.0 nM			NPASS
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens	P18031		100000 nM			BindingDB
Urease subunit alpha/Urease subunit beta	Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)			= 138000.0 nM			NPASS
Urease subunit beta	Helicobacter pylori (strain ATCC 700392 / 26695)	P69996		138000 nM			BindingDB
Xanthine dehydrogenase	Bos taurus	P80457		= 10210.0 nM\|= 3570.0 nM			NPASS
Xanthine dehydrogenase	Homo sapiens	P47989		= 700.0 nM\|= 3200.0 nM		= 520.0 nM	NPASS
Xanthine dehydrogenase/oxidase	Bos taurus	P80457		10210 nM\|3570 nM			BindingDB
Homeobox protein Nkx-2.5/Transcription factor GATA-4	Mus musculus	P42582\|Q08369		24000 nM			BindingDB
Tyrosine-protein kinase LCK	Homo sapiens	P06239		= 4.0 ug.mL-1			NPASS
Prostaglandin G/H synthase 1	Ovis aries	P05979		>370000 nM			BindingDB
Solute carrier family 22 member 1	Homo sapiens	O15245		= 38880.0 nM			NPASS
Sialidase 2	Homo sapiens	Q9Y3R4		= 570000.0 nM			NPASS
Prostaglandin G/H synthase 2	Ovis aries	P79208		>370000 nM			BindingDB
Proteasome Macropain subunit MB1	Homo sapiens	P28074		= 1000.0 nM\|= 1800.0 nM			NPASS
Proteasome subunit beta type-5	Homo sapiens	P28074		1000 nM\|1800 nM			BindingDB
Protein kinase Pfmrk	Plasmodium falciparum	P90584		= 7000.0 nM			NPASS
Pyruvate kinase PKM	Homo sapiens	P14618		990 nM			BindingDB
Pyruvate kinase isozymes M1/M2	Homo sapiens	P14618		= 990.0 nM			NPASS
RBL-2H3	Rattus norvegicus			= 124000.0 nM			NPASS
Radical scavenging activity				> 100.0 ug.mL-1			NPASS
Rattus norvegicus	Rattus norvegicus			= 3400.0 nM\|> 30000.0 nM			NPASS
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens	P36888		1450 nM			BindingDB
Sialidase-2	Homo sapiens	Q9Y3R4		570000 nM			BindingDB
Replicase polyprotein 1ab	Human SARS coronavirus	P0C6X7		280000 nM\|280800 nM			BindingDB
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus	P0C6X7		280800 nM			BindingDB
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	P0DTD1		= 3020.0 nM			NPASS
Reverse transcriptase	Human immunodeficiency virus 1			443000 nM			BindingDB
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2		= 5100.0 nM	> 20000.0 nM\|> 19952.62 nM			NPASS
Seed linoleate 13S-lipoxygenase-1	Glycine max	P08170				178300 nM	BindingDB
Seed lipoxygenase-1	Glycine max	P08170				= 178300.0 nM	NPASS
Serine protease 1	Bos taurus	P00760		141500 nM			BindingDB
Serine/threonine-protein kinase pim-1	Homo sapiens	P11309		940 nM\|933 nM			BindingDB
Short transient receptor potential channel 5	Homo sapiens	Q9UL62		>10000 nM\|> 10000.0 nM			BindingDB, NPASS
Sialidase	Clostridium perfringens	P10481		17400 nM\|= 17400.0 nM			BindingDB, NPASS
Replicase polyprotein 1ab	Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC)	K9N7C7		> 10000.0 nM			NPASS
Histone deacetylase 6	Homo sapiens	Q9UBN7		= 1035.0 nM			NPASS
Estrogen receptor	Ovis aries	Q9TU15			= 660.0 nM		NPASS
HepG2	Homo sapiens			= 70180.0 nM			NPASS
Beta-glucuronidase	Rattus norvegicus	P06760		2800 nM\|= 2800.0 nM			BindingDB, NPASS
Beta-secretase 1	Homo sapiens	P56817		38500 nM\|= 38500.0 nM\|= 3790.0 nM		11310 nM	BindingDB, NPASS
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens	Q9UNQ0		5900 nM\|3100 nM\|16000 nM			BindingDB
Butyrylcholinesterase	Homo sapiens	P06276				= 37400.0 nM	NPASS
Butyrylcholinesterase	Rattus norvegicus	Q9JKC1		> 500000.0 nM\|> 50000.0 nM			NPASS
C2C12	Mus musculus			= 26.58 ug.mL-1			NPASS
Candida albicans	Candida albicans			> 50.0 ug.mL-1			NPASS
Carbonic anhydrase 1	Homo sapiens	P00915				4100 nM	BindingDB
Carbonic anhydrase 2	Homo sapiens	P00918				2700 nM	BindingDB
Carbonic anhydrase 3	Bovine	Q3SZX4				11600 nM	BindingDB
Carbonic anhydrase 4	Homo sapiens	P22748				9100 nM	BindingDB
Carboxylic ester hydrolase	Rattus norvegicus			>500000 nM			BindingDB
Casein kinase 2	Homo sapiens			= 800.0 nM		= 440.0 nM	NPASS
Casein kinase 2	Rattus norvegicus			= 800.0 nM			NPASS
Casein kinase II	Homo sapiens	P19784		= 800.0 nM\|< 1000.0 nM			NPASS
Casein kinase II alpha	Homo sapiens	P68400		= 800.0 nM		= 740.0 nM	NPASS
Casein kinase II subunit alpha	Homo sapiens	P68400		800 nM		740 nM	BindingDB
Cell division protein kinase 5	Rattus norvegicus	Q03114	> 250000.0 nM				NPASS
Chikungunya virus	Chikunguvirus			= 22500.0 nM			NPASS
Cholinesterase	Homo sapiens	P06276				37400 nM	BindingDB
Cyclin homolog/dependent kinase 6	Saimiriine herpesvirus 2 (strain 11)	Q00534\|Q01043		1700 nM			BindingDB
Aurora kinase B	Homo sapiens	Q96GD4		3.96e+3 nM			BindingDB
Aromatase	Homo sapiens	P11511		10000 nM\|1200 nM\|1000 nM\|900 nM			BindingDB
Angiotensin-converting enzyme	Oryctolagus cuniculus	P12822		280000000 nM\|280000 nM\|= 280000000.0 nM\|= 280000.0 nM			BindingDB, NPASS
Androgen receptor	Homo sapiens	P10275		5200 nM			BindingDB
Hepatitis C virus	Hepatitis C virus		= 7900.0 nM\|= 12000.0 nM				NPASS
17-beta-hydroxysteroid dehydrogenase type 1	Homo sapiens	P14061		710 nM			BindingDB
17-beta-hydroxysteroid dehydrogenase type 2	Homo sapiens	P37059		>20000 nM			BindingDB
17-beta-hydroxysteroid dehydrogenase type 3	Homo sapiens	P37058		2.13e+4 nM\|1.64e+4 nM			BindingDB
A549	Homo sapiens		= 101000.0 nM				NPASS
ATP-binding cassette sub-family G member 2	Homo sapiens	Q9UNQ0		= 3100.0 nM\|= 5900.0 nM\|= 16000.0 nM			NPASS
ATP-dependent translocase ABCB1	Homo sapiens	P08183			10000 nM		BindingDB
Acetylcholinesterase	Homo sapiens	P22303		64270 nM\|12 nM\|= 12.0 nM\|= 3420.0 nM		121600 nM\|= 121600.0 nM	BindingDB, NPASS
Acetylcholinesterase	Rattus norvegicus	P37136		>500000 nM\|> 500000.0 nM\|> 50000.0 nM			BindingDB, NPASS
Adenosine A1 receptor	Rattus norvegicus	P25099				= 3000.0 nM	NPASS
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B	Marthasterias glacialis	P15206\|Q9DGD3		4000 nM			BindingDB
Adenosine A2a receptor	Rattus norvegicus	P30543				= 7580.0 nM	NPASS
Adenosine receptor A2a	Rattus norvegicus	P30543				7586 nM\|7580 nM	BindingDB
Aldo-keto reductase family 1 member B1	Homo sapiens	P15121		11900 nM			BindingDB
Aldo-keto reductase family 1 member B1	Rattus norvegicus	P07943		6670 nM			BindingDB
Aldo-keto reductase family 1 member B10	Homo sapiens	O60218		37100 nM\|6600 nM\|= 37100.0 nM\|= 6600.0 nM		6000 nM\|= 6000.0 nM	BindingDB, NPASS
Aldose reductase	Homo sapiens	P15121		= 11900.0 nM			NPASS
Aldose reductase	Rattus norvegicus	P07943		= 6670.0 nM			NPASS
Amine oxidase [flavin-containing] A	Homo sapiens	P21397		1700 nM\|640 nM\|1550 nM			BindingDB
Amine oxidase [flavin-containing] B	Homo sapiens	P27338		12800 nM\|1120 nM			BindingDB
Amyloid-beta precursor protein	Homo sapiens	P05067		23000 nM\|176200 nM\|>50000 nM			BindingDB
Androgen Receptor	Homo sapiens	P10275		= 5200.0 nM			NPASS
Adenosine receptor A1	Rattus norvegicus	P25099				3020 nM\|3000 nM	BindingDB
Cyclin-dependent kinase 1/cyclin B	Homo sapiens	O95067		= 4000.0 nM			NPASS
Casein kinase II subunit alpha 3	Homo sapiens	Q8NEV1		800 nM			BindingDB
Cyclin-dependent kinase 5 activator 1 [99-307]	Homo sapiens	Q00535\|Q15078		1600 nM			BindingDB
Estradiol 17-beta-dehydrogenase 1	Homo sapiens	P14061		= 710.0 nM			NPASS
Estradiol 17-beta-dehydrogenase 2	Homo sapiens	P37059		> 20000.0 nM			NPASS
Estrogen receptor	Homo sapiens	P03372		1253 nM\|= 14000.0 nM			BindingDB, NPASS
Estrogen receptor alpha	Homo sapiens	P03372		= 1253.0 nM			NPASS
Cyclin-dependent kinase 5	Rattus norvegicus	Q03114	>250000 nM				BindingDB
Estrogen receptor beta	Homo sapiens	Q92731		130 nM\|= 130.0 nM			BindingDB, NPASS
Estrogen receptor beta	Ovis aries	Q9TU15			660 nM		BindingDB
Filobasidiella neoformans	Cryptococcus neoformans			= 20.0 ug.mL-1			NPASS
GABA-A receptor; anion channel	Homo sapiens	Q16445				= 3019.95 nM	NPASS
GABA-A receptor; anion channel	Rattus norvegicus	Q9ES14				= 770.0 nM	NPASS
Epidermal growth factor receptor erbB1	Homo sapiens	P00533		= 30.0 ug.mL-1			NPASS
GATA4/NKX2-5	Mus musculus			= 24000.0 nM			NPASS
Glycogen synthase kinase-3 beta	Homo sapiens	P49841	49490 nM	1900 nM\|= 1900.0 nM			BindingDB, NPASS
Glycogen synthase kinase-3 beta	Rattus norvegicus	P18266		1400 nM			BindingDB
H9	Homo sapiens		= 9.0 ug.mL-1	= 35.0 ug.mL-1\|= 35000.0 nM			NPASS
HCT-116	Homo sapiens			= 27900.0 nM			NPASS
HL-60	Homo sapiens			= 22300.0 nM			NPASS
HT-1080	Homo sapiens		= 36600.0 nM				NPASS
HT-22	Mus musculus		> 100000.0 nM				NPASS
HT-29	Homo sapiens			= 2000.0 nM			NPASS
HeLa	Homo sapiens		= 92700.0 nM	>= 10000.0 nM\|= 21300.0 nM\|= 6092.0 nM			NPASS
HeLa S3	Homo sapiens			> 10000.0 nM			NPASS
Glycogen synthase kinase-3	Homo sapiens	P49841		= 1400.0 nM			NPASS
Epidermal growth factor receptor	Homo sapiens	P00533		111000 nM			BindingDB
Estrogen receptor beta	Homo sapiens	P03372\|Q92731		14000 nM			BindingDB
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum	Q965D5		= 50000.0 nM			NPASS
Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Q15078		= 1600.0 nM			NPASS
Cyclin-dependent kinase 6	Homo sapiens	Q00534		1700 nM\|= 1700.0 nM			BindingDB, NPASS
Cyclooxygenase-1	Ovis aries	P05979		> 100.0 ug.mL-1			NPASS
Cyclooxygenase-2	Homo sapiens	P35354		= 8000.0 nM			NPASS
Entamoeba histolytica	Eoeba histolytica			= 12.7 ug.mL-1			NPASS
Cystic fibrosis transmembrane conductance regulator	Homo sapiens	P13569	9000 nM\|= 9000.0 nM			81000 nM\|= 81000.0 nM\|= 4800.0 nM	BindingDB, NPASS
Cytochrome P450 19A1	Homo sapiens	P11511		= 10000.0 nM\|= 1000.0 nM\|= 900.0 nM\|= 1200.0 nM\|= 2897.34 nM			NPASS
Cytochrome P450 1A1	Homo sapiens	P04798		427 nM\|= 427.0 nM		390 nM\|= 390.0 nM	BindingDB, NPASS
Cytochrome P450 1A2	Homo sapiens	P05177		795 nM\|= 795.0 nM			BindingDB, NPASS
Cytochrome P450 1B1	Homo sapiens	Q16678		25 nM\|360 nM\|= 25.0 nM\|= 360.0 nM		64 nM\|= 64.0 nM	BindingDB, NPASS
D-alanine--D-alanine ligase	Helicobacter pylori (strain HPAG1)	Q1CTD3		132700 nM\|= 132700.0 nM		31000 nM\|= 31000.0 nM	BindingDB, NPASS
Cyclooxygenase-2	Ovis aries	P79208		> 100.0 ug.mL-1			NPASS
D-alanylalanine synthetase	Escherichia coli K-12	P07862		= 163000.0 nM			NPASS
D-alanine--D-alanine ligase B	Escherichia coli (strain K12)	P07862		163000 nM			BindingDB
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum			50000 nM			BindingDB
Dipeptidyl peptidase IV	Homo sapiens	P27487		= 140.0 nM			NPASS
Dipeptidyl peptidase 3	Homo sapiens	Q9NY33		5.40e+4 nM			BindingDB
Death-associated protein kinase 1	Homo sapiens	P53355		31000 nM\|= 31000.0 nM			BindingDB, NPASS
Dipeptidyl peptidase 4	Homo sapiens	P27487		140 nM			BindingDB
DNA polymerase eta	Homo sapiens	Q9Y253		= 22200.0 nM			NPASS
DNA gyrase A/A/B/B tetramer	Escherichia coli (strain K12)	P0AES4\|P0AES6		250000 nM			BindingDB
DNA gyrase	Escherichia coli K-12	P0AES4		= 67.6 ug.mL-1			NPASS
DLD-1	Homo sapiens			= 89500.0 nM			NPASS

a curated database

IMPPAT Phytochemical information:
Apigenin

Bioactivity information

IMPPAT Phytochemical information: Apigenin

Bioactivity information

IMPPAT Phytochemical information:
Apigenin