IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Ki	Source
No relevant target			= 12130.0 nM	= 32200.0 nM\|= 0.8 ug.mL-1		NPASS
Neuraminidase	InflueA virus (strain A/Wilson-Smith/1933 H1N1) (InflueA virus(strain A/WS/1933 H1N1))	P03470		> 100000.0 nM		NPASS
Neuraminidase	InflueA virus (strain A/Wilson-Smith/1933 H1N1)	P03470		>100000 nM		BindingDB
NON-PROTEIN TARGET			= 12600.0 nM	= 2800.0 nM\|= 2200.0 nM\|= 25900.0 nM\|= 10200.0 nM\|= 0.5 ug.mL-1\|= 553800.0 nM\|= 5370.0 nM\|= 58000.0 nM\|= 18250.0 nM\|= 1.54 ug.mL-1\|= 17900.0 nM\|= 0.57 ug.mL-1\|= 0.38 ug.mL-1\|= 0.37 ug.mL-1\|> 100000.0 nM\|> 1000.0 nM		NPASS
Mus musculus	Mus musculus			> 100000.0 nM\|= 190.0 nM		NPASS
Meloidogyne incognita	Meloidogyne incognita		> 1000.0 ug.mL-1			NPASS
Matrix metalloproteinase-9	Homo sapiens	P14780		21 nM\|10.0 nM		BindingDB
Matrix metalloproteinase-2	Homo sapiens	P08253		= 24.26 nM		NPASS
Matrix metalloproteinase-1	Homo sapiens	P03956		= 238.91 nM		NPASS
Matrix metalloproteinase 9	Homo sapiens	P14780		= 21.22 nM\|= 10.0 nM		NPASS
MV4-11	Homo sapiens			> 10000.0 nM		NPASS
MOLM-14	Homo sapiens			> 10000.0 nM		NPASS
MOLM-13	Homo sapiens			= 6400.0 nM		NPASS
MCF7	Homo sapiens			> 550000.0 nM		NPASS
Lysosomal alpha-glucosidase	Rattus norvegicus	Q6P7A9		34690 nM		BindingDB
Lysine-specific demethylase 5B	Homo sapiens	Q9UGL1		= 2880.0 nM		NPASS
Lipoxygenase	Solanum tuberosum			3000 nM\|4000 nM		BindingDB
Linoleate 9S-lipoxygenase-4	Glycine max	P38417		600000 nM		BindingDB
Leishmania panamensis	Leishmapanamensis		= 1103460.0 nM			NPASS
Leishmania donovani	Leishmadonovani			= 31100.0 nM		NPASS
Leishmania amazonensis	Leishmaamazonensis			= 17800.0 nM\|= 5200.0 nM\|= 16000.0 nM		NPASS
Large T antigen	Simian virus 40	P03070		7300 nM		BindingDB
LNCaP	Homo sapiens			> 100000.0 nM		NPASS
Interstitial collagenase	Homo sapiens	P03956		239 nM		BindingDB
Integrase	Human immunodeficiency virus 1			2800 nM\|24000 nM\|>100000 nM		BindingDB
Influenza A virus	InflueA virus		> 100000.0 nM			NPASS
Hyaluronidase-1	Homo sapiens	Q12794		>2000000 nM\|> 2000000.0 nM		BindingDB, NPASS
Human immunodeficiency virus type 1 integrase	Human immunodeficiency virus 1	Q7ZJM1		= 2800.0 nM\|= 24000.0 nM\|> 100000.0 nM		NPASS
Histone deacetylase	Homo sapiens	Q969S8		= 2540000.0 nM	= 10840.0 nM	NPASS
PC-12	Rattus norvegicus			= 75800.0 nM		NPASS
Pancreatic triacylglycerol lipase	Sus scrofa	P00591		>1000000 nM\|> 1000000.0 nM		BindingDB, NPASS
Plasmodium falciparum	Plasmodium falciparum			= 122000.0 nM		NPASS
Polyphenol oxidase 2	Agaricus bisporus	O42713		>350000 nM		BindingDB
n.a.				= 3.79 ug.mL-1		NPASS
Vero	Chlorocebus aethiops			> 550000.0 nM		NPASS
U-937	Homo sapiens		= 9900.0 nM	= 316500.0 nM		NPASS
Tyrosine-protein phosphatase non-receptor type 7	Homo sapiens	P35236		>100000 nM		BindingDB
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens	P18031		3060 nM		BindingDB
Tyrosinase	Agaricus bisporus	O42713		> 350000.0 nM		NPASS
Type-1 angiotensin II receptor	Homo sapiens	P30556		125 nM\|= 124.6 nM		BindingDB, NPASS
Trypanosoma cruzi	Trypanosoma cruzi		= 156920.0 nM	= 166630.0 nM		NPASS
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense			= 6110.0 nM		NPASS
Trypanosoma brucei brucei	Trypanosoma brucei brucei			< 30000.0 nM		NPASS
Transthyretin	Homo sapiens	P02766	97000 nM\|= 97000.0 nM			BindingDB, NPASS
T47D	Homo sapiens			= 2.0 nM		NPASS
Sucrase-isomaltase	Rattus norvegicus	P23739		= 87450.0 nM		NPASS
Staphylococcus epidermidis	Staphylococcus epidermidis		= 2780.0 nM			NPASS
Histone deacetylase	Homo sapiens	O15379\|P56524\|Q13547\|Q8WUI4\|Q92769\|Q969S8\|Q96DB2\|Q9BY41\|Q9UBN7\|Q9UKV0\|Q9UQL6		2540000 nM	10840 nM	BindingDB
Staphylococcus aureus	Staphylococcus aureus		= 2780.0 nM			NPASS
Sortase A	Staphylococcus aureus	Q9S446		= 860400.0 nM		NPASS
Siderophore-binding protein	Mycobacterium tuberculosis				5.7e+2 nM	BindingDB
Seed lipoxygenase-1	Glycine max	P08170		= 3000.0 nM\|= 600000.0 nM		NPASS
Seed linoleate 13S-lipoxygenase-1	Glycine max	P08170		6.00e+5 nM\|600000 nM\|3000 nM		BindingDB
SH-SY5Y	Homo sapiens		= 33820.0 nM			NPASS
Radical scavenging activity			= 3.0 ug\|= 17800.0 nM\|= 136500.0 nM\|= 9480.0 nM	= 2900.0 nM\|= 2800.0 nM\|= 31700.0 nM\|= 3700.0 nM\|= 66700.0 nM\|= 12.0 ug.mL-1\|= 3.2 ug.mL-1\|= 21110.0 nM\|= 34100.0 nM\|= 41000.0 nM\|= 5700.0 nM\|= 1.8 ug.mL-1\|= 18100.0 nM\|= 0.39 ug.mL-1\|= 150.0 nM\|= 15300.0 nM		NPASS
RAW264.7	Mus musculus		= 3406000.0 nM\|= 165295.0 nM			NPASS
Protein-tyrosine phosphatase LC-PTP	Homo sapiens	P35236		> 100000.0 nM		NPASS
Protein-tyrosine phosphatase 1B	Homo sapiens	P18031		= 3060.0 nM		NPASS
Prostaglandin G/H synthase 2	Homo sapiens	P35354		129700 nM		BindingDB
Prostaglandin G/H synthase 1	Homo sapiens	P23219		>400000 nM		BindingDB
Prolyl 4-hydroxylase subunit alpha-1	Gallus gallus	P16924			18000 nM	BindingDB
Polyunsaturated fatty acid 5-lipoxygenase	Rattus norvegicus	P12527		43000 nM		BindingDB
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens	P09917		16700 nM\|>10000 nM\|8500 nM\|25000 nM		BindingDB
Sortase family protein	Staphylococcus aureus			860400 nM		BindingDB
Heat shock protein HSP90	Homo sapiens	P08238		> 50000.0 nM		NPASS
Sucrase-isomaltase, intestinal	Rattus norvegicus	P23739		87450 nM		BindingDB
HeLa	Homo sapiens			= 44.0 ug.mL-1		NPASS
Carbonic anhydrase 4	Homo sapiens	P22748			10100 nM	BindingDB
Carbonic anhydrase 3	Homo sapiens	P07451			10000 nM	BindingDB
Carbonic anhydrase 2	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	P9WPJ9			5.9e+2 nM	BindingDB
Carbonic anhydrase 2	Homo sapiens	P00918			1610 nM	BindingDB
Carbonic anhydrase 14	Homo sapiens	Q9ULX7			8710 nM	BindingDB
Carbonic anhydrase 13	Mus musculus	Q9D6N1			10900 nM	BindingDB
Carbonic anhydrase 12	Homo sapiens	O43570			9060 nM	BindingDB
Carbonic anhydrase 1	Homo sapiens	P00915			2380 nM	BindingDB
Heat shock protein HSP 90-alpha	Homo sapiens	P07900		50000 nM		BindingDB
BiP isoform A	Glycine max			600000 nM		BindingDB
Beta-secretase 1	Homo sapiens	P56817		= 16670.0 nM		NPASS
Beta-carbonic anhydrase 1	Mycobacterium tuberculosis	P9WPJ7			5.92e+3 nM	BindingDB
Beta amyloid A4 protein	Homo sapiens	P05067		= 32800.0 nM		NPASS
Arginase-1	Bos taurus	Q2KJ64		131000 nM\|= 131000.0 nM		BindingDB, NPASS
Arachidonate 5-lipoxygenase	Rattus norvegicus	P12527		= 43000.0 nM		NPASS
Arachidonate 5-lipoxygenase	Homo sapiens	P09917		= 16700.0 nM\|= 25000.0 nM\|> 10000.0 nM\|= 8500.0 nM		NPASS
Anthrax toxin receptor 2	Homo sapiens	P58335		>300000 nM\|> 300000.0 nM		BindingDB, NPASS
Amyloid-beta precursor protein	Homo sapiens	P05067	216000 nM	15600 nM\|32800 nM		BindingDB
Alpha-glucosidase MAL62	Saccharomyces cerevisiae	P07265		>300000 nM\|> 300000.0 nM		BindingDB, NPASS
Aldose reductase	Homo sapiens	P15121		= 32000.0 nM		NPASS
Aldo-keto reductase family 1 member B10	Homo sapiens	O60218		90000 nM\|= 90000.0 nM		BindingDB, NPASS
Aldo-keto reductase family 1 member B1	Homo sapiens	P15121		32000 nM		BindingDB
Acidic alpha-glucosidase	Rattus norvegicus	Q6P7A9		= 34690.0 nM		NPASS
Acetylcholinesterase	Homo sapiens	P22303		5.551e+6 nM\|>100000 nM\|> 100000.0 nM		BindingDB, NPASS
Acetylcholinesterase	Electrophorus electricus	O42275		= 5551000.0 nM		NPASS
AGS	Homo sapiens			= 129000.0 nM		NPASS
A549	Homo sapiens			> 100000.0 nM\|= 500000.0 nM\|= 700000.0 nM		NPASS
72 kDa type IV collagenase	Homo sapiens	P08253		24 nM		BindingDB
5-lipoxygenase	Solanum tuberosum	O49150		= 3000.0 nM\|= 4000.0 nM		NPASS
Carbonic anhydrase 5A, mitochondrial	Homo sapiens	P35218			6490 nM	BindingDB
Carbonic anhydrase 5B, mitochondrial	Homo sapiens	Q9Y2D0			9080 nM	BindingDB
BiP isoform A	Glycine max	Q39830		= 600000.0 nM		NPASS
Carbonic anhydrase 7	Homo sapiens	P43166			6420 nM	BindingDB
HT-29	Homo sapiens			= 27160.0 nM		NPASS
HT-22	Mus musculus		> 10000000.0 nM\|= 77100.0 nM			NPASS
HCT-116	Homo sapiens			= 29730.0 nM		NPASS
Carbonic anhydrase 6	Homo sapiens	P23280			7330 nM	BindingDB
Gag-Pol polyprotein	HIV-1	P04585		>50000 nM		BindingDB
Erythrocyte				= 750000.0 nM\|= 940000.0 nM		NPASS
Epidermal growth factor receptor erbB1	Homo sapiens	P00533		= 1200000.0 nM\|= 1000000.0 nM	= 400000.0 nM	NPASS
Epidermal growth factor receptor	Homo sapiens	P00533		1200000 nM\|1000000 nM	400000 nM	BindingDB
Dual specificity protein phosphatase 3	Homo sapiens	P51452		>100000 nM\|> 100000.0 nM		BindingDB, NPASS
Dipeptidyl peptidase IV	Homo sapiens	P27487		= 3370.0 nM		NPASS
Dipeptidyl peptidase 4	Homo sapiens	P27487		3370 nM		BindingDB
Dihydroorotate dehydrogenase (fumarate)	Leishmamajor	Q4QEW7		= 1753000.0 nM\|= 1584893.19 nM		NPASS
Dihydroorotate dehydrogenase (fumarate)	Leishmamajor			1750000 nM\|1753000 nM		BindingDB
DNA-directed RNA polymerase subunit beta	Escherichia coli			23775.9 nM		BindingDB
Cyclooxygenase-2	Homo sapiens	P35354		= 129700.0 nM		NPASS
Glutamate carboxypeptidase 2	Homo sapiens	Q04609		100.0 nM\|300 nM		BindingDB
Catechol O-methyltransferase	Rattus norvegicus	P22734		93 nM\|5861 nM\|= 92.82 nM\|= 5861.0 nM		BindingDB, NPASS
Cyclooxygenase-1	Homo sapiens	P23219		> 400000.0 nM		NPASS
Carbonic anhydrase 9	Homo sapiens	Q16790			7870 nM	BindingDB
Carbonic anhydrase II	Homo sapiens	P00918			= 1610.0 nM	NPASS
Carbonic anhydrase III	Homo sapiens	P07451			= 10000.0 nM	NPASS
Carbonic anhydrase IV	Homo sapiens	P22748			= 10100.0 nM	NPASS
Carbonic anhydrase IX	Homo sapiens	Q16790			= 7870.0 nM	NPASS
Carbonic anhydrase I	Homo sapiens	P00915			= 2380.0 nM	NPASS
Carbonic anhydrase VB	Homo sapiens	Q9Y2D0			= 9080.0 nM	NPASS
Carbonic anhydrase VI	Homo sapiens	P23280			= 7330.0 nM	NPASS
Carbonic anhydrase VII	Homo sapiens	P43166			= 6420.0 nM	NPASS
Carbonic anhydrase XII	Homo sapiens	O43570			= 9060.0 nM	NPASS
Carbonic anhydrase XIII	Mus musculus	Q9D6N1			= 10900.0 nM	NPASS
Carbonic anhydrase VA	Homo sapiens	P35218			= 6490.0 nM	NPASS
Carbonic anhydrase XIV	Homo sapiens	Q9ULX7			= 8710.0 nM	NPASS

a curated database

IMPPAT Phytochemical information:
Caffeic acid

Bioactivity information

IMPPAT Phytochemical information: Caffeic acid

Bioactivity information

IMPPAT Phytochemical information:
Caffeic acid