IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Liver microsomes	Rattus norvegicus			= 19000000.0 nM			NPASS
Lactoylglutathione lyase	Homo sapiens	Q04760		20600 nM			BindingDB
Leishmania amazonensis	Leishmaamazonensis			= 27560.0 nM			NPASS
Leishmania braziliensis	Leishmabraziliensis			= 53650.0 nM			NPASS
Leishmania donovani	Leishmadonovani			= 10140.0 nM			NPASS
Leishmania peruviana	Leishmaperuviana			= 71290.0 nM			NPASS
L929	Mus musculus		= 20000.0 nM\|= 25000.0 nM				NPASS
Lysosomal alpha-glucosidase	Rattus norvegicus	Q6P7A9		59540 nM			BindingDB
Mitogen-activated protein kinase 14	Homo sapiens	Q16539		1.84e+4 nM			BindingDB
MDA-MB-231	Homo sapiens			> 20.0 ug.mL-1			NPASS
Mitogen-activated protein kinase 10	Homo sapiens	P53779		1.91e+4 nM			BindingDB
J774.2				= 53670.0 nM			NPASS
Multidrug resistance-associated protein 1	Homo sapiens	P33527				2400 nM\|= 2400.0 nM	BindingDB, NPASS
Myeloperoxidase	Homo sapiens	P05164		2240 nM\|= 2240.0 nM			BindingDB, NPASS
NADPH oxidase 4	Homo sapiens	Q9NPH5		1200 nM\|= 1200.0 nM			BindingDB, NPASS
Neuraminidase	InflueA virus	B4URF0		= 58600.0 nM\|= 38100.0 nM\|= 46400.0 nM\|= 11200.0 nM		= 21100.0 nM	NPASS
Neuraminidase	InflueA virus (A/Puerto Rico/8/1934(H1N1))	P03468		= 16.77 ug.mL-1			NPASS
Neuraminidase	InflueA virus (A/WSN/1933(H1N1))	P03470		58600 nM\|38100 nM\|46400 nM			BindingDB
MCF7	Homo sapiens			> 20.0 ug.mL-1\|> 10000.0 nM\|= 50000.0 nM			NPASS
Interstitial collagenase [100-268]	Human	P03956		1.35e+3 nM\|3.92e+3 nM			BindingDB
Inhibitor of apoptosis protein 3	Homo sapiens	P98170		> 100000.0 nM			NPASS
Inositol polyphosphate multikinase	Homo sapiens	Q8NFU5		4400 nM\|= 4400.0 nM			BindingDB, NPASS
Neuraminidase	InflueA virus (strain A/Puerto Rico/8/1934 H1N1)	P03468		59300 nM\|58500 nM			BindingDB
Glycogen synthase kinase-3 beta	Homo sapiens	P49841	11590 nM				BindingDB
Glycogen synthase kinase-3 beta	Rattus norvegicus	P18266		3500 nM			BindingDB
Glyoxalase I	Homo sapiens	Q04760		= 20600.0 nM			NPASS
HCC1937	Homo sapiens			> 10000.0 nM			NPASS
HCT-116	Homo sapiens			> 10000.0 nM			NPASS
HL-60	Homo sapiens			= 10.0 ug.mL-1			NPASS
HT-29	Homo sapiens			> 100000.0 nM			NPASS
HeLa	Homo sapiens			= 2.4 ug.mL-1\|> 100000.0 nM			NPASS
HepG2	Homo sapiens		= 7740.0 nM	> 20.0 ug.mL-1\|> 400000.0 nM\|> 10000.0 nM			NPASS
Histone deacetylase 6	Homo sapiens	Q9UBN7		= 1714.0 nM			NPASS
Histone-lysine N-methyltransferase SETD7	Homo sapiens	Q8WTS6		>200000 nM\|> 200000.0 nM			BindingDB, NPASS
Human immunodeficiency virus 1	Human immunodeficiency virus 1		< 100000.0 nM				NPASS
Human immunodeficiency virus type 1 integrase	Human immunodeficiency virus 1	Q7ZJM1		= 97800.0 nM\|= 64700.0 nM			NPASS
Human immunodeficiency virus type 1 reverse transcriptase	Human immunodeficiency virus 1	Q72547		< 150.0 ug.mL-1			NPASS
Influenza A virus	InflueA virus		= 18500.0 nM				NPASS
Influenza A virus (A/PR/8/34(H1N1))	InflueA virus (A/Puerto Rico/8/1934(H1N1))		= 30200.0 nM				NPASS
Inositol hexakisphosphate kinase 2	Homo sapiens	Q9UHH9		2500 nM\|= 2500.0 nM			BindingDB, NPASS
Glycogen synthase kinase-3	Homo sapiens	P49841		= 3500.0 nM			NPASS
Integrase	Human immunodeficiency virus 1			64700 nM\|97800 nM			BindingDB
Neuraminidase	InflueA virus (strain A/USSR/90/1977 H1N1)	P03469		42200 nM\|85200 nM\|= 42200.0 nM\|= 85200.0 nM			BindingDB, NPASS
Serine protease 1	Bos taurus	P00760		105900 nM			BindingDB
P-glycoprotein 1	Homo sapiens	P08183			= 6760.83 nM		NPASS
Serine/threonine-protein kinase pim-1	Homo sapiens	P11309		1300 nM\|1288 nM			BindingDB
Short transient receptor potential channel 5	Homo sapiens	Q9UL62		3900 nM\|= 3900.0 nM			BindingDB, NPASS
Sialidase	Clostridium perfringens	P10481		8000 nM\|= 8000.0 nM			BindingDB, NPASS
Sialidase 2	Homo sapiens	Q9Y3R4		= 230000.0 nM			NPASS
Sialidase-2	Homo sapiens	Q9Y3R4		230000 nM			BindingDB
Solute carrier organic anion transporter family member 2B1	Homo sapiens	O94956		= 40900.0 nM\|= 40738.03 nM			NPASS
Steroid hormone receptor ERR1	Homo sapiens	P11474		9640 nM			BindingDB
Trypanosoma brucei brucei	Trypanosoma brucei brucei			= 9000.0 nM			NPASS
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense			= 32160.0 nM			NPASS
Trypanosoma cruzi	Trypanosoma cruzi			= 83550.0 nM			NPASS
Trypsin I	Bos taurus	P00760		= 105900.0 nM			NPASS
Tyrosinase	Agaricus bisporus	O42713		> 100000.0 nM\|= 171400.0 nM			NPASS
Tyrosinase	Homo sapiens	P14679		1000 nM\|= 1000.0 nM\|= 65110.0 nM			BindingDB, NPASS
Tyrosine-protein kinase YES	Homo sapiens	P07947				= 6770.0 nM	NPASS
Tyrosine-protein kinase Yes	Homo sapiens	P07947				6770 nM	BindingDB
Tyrosine-protein kinase receptor FLT3	Homo sapiens	P36888		= 2320.0 nM			NPASS
Xanthine dehydrogenase	Homo sapiens	P47989		= 1060.0 nM			NPASS
Xanthine dehydrogenase/oxidase	Homo sapiens	P47989		1060 nM			BindingDB
Glucose transporter	Homo sapiens	P11166		= 4000.0 nM			NPASS
SK-OV-3	Homo sapiens			> 10000.0 nM			NPASS
No relevant target				= 15510.0 nM\|= 81570.0 nM\|= 4730.0 nM			NPASS
SK-MEL-2	Homo sapiens			> 10000.0 nM			NPASS
Ribosomal protein S6 kinase alpha 3	Homo sapiens	P51812		= 1710.0 nM			NPASS
P-glycoprotein 3	Mus musculus	P21447			= 6700.0 nM		NPASS
Pancreatic triacylglycerol lipase	Sus scrofa	P00591		>70000 nM\|>100000 nM\|> 70000.0 nM\|> 100000.0 nM			BindingDB, NPASS
Peroxisome proliferator-activated receptor alpha	Homo sapiens	Q07869	= 15500.0 nM				NPASS
Peroxisome proliferator-activated receptor delta	Homo sapiens	Q03181	= 341400.0 nM				NPASS
Peroxisome proliferator-activated receptor gamma	Homo sapiens	P37231		= 23100.0 nM			NPASS
Plasmodium falciparum	Plasmodium falciparum			= 30400.0 nM			NPASS
Polyphenol oxidase 2	Agaricus bisporus	O42713		>100000 nM\|171400 nM			BindingDB
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens	P09917		2700 nM			BindingDB
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	P12530		2200 nM			BindingDB
Prolyl endopeptidase	Homo sapiens	P48147		>200000 nM\|> 200000.0 nM			BindingDB, NPASS
Prostaglandin G/H synthase 1	Homo sapiens	P23219		>100000 nM			BindingDB
Prostaglandin G/H synthase 2	Homo sapiens	P35354		>100000 nM			BindingDB
Proteasome Macropain subunit MB1	Homo sapiens	P28074		= 10500.0 nM\|= 11000.0 nM			NPASS
Proteasome subunit beta type-5	Homo sapiens	P28074		10500 nM\|11000 nM			BindingDB
Protein E6	Human papillomavirus type 16	P03126		>20000 nM\|> 20000.0 nM			BindingDB, NPASS
RAW264.7	Mus musculus			< 15000.0 nM\|= 60200.0 nM\|= 80300.0 nM\|= 17000.0 nM\|= 13400.0 nM\|= 15000.0 nM			NPASS
Radical scavenging activity			= 4.4 ug\|= 14.6 ug	= 74.4 ug.mL-1\|= 89700.0 nM\|= 2.51 ug.mL-1\|= 14.78 ug.mL-1			NPASS
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens	P36888		2320 nM			BindingDB
Reverse transcriptase	Human immunodeficiency virus 1			<524000 nM			BindingDB
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2		= 3000.0 nM	> 20000.0 nM\|> 19952.62 nM			NPASS
Filobasidiella neoformans	Cryptococcus neoformans			> 50.0 ug.mL-1			NPASS
NON-PROTEIN TARGET				= 840.0 nM\|= 88000.0 nM\|= 17.74 ug.mL-1\|= 3.55 ug.mL-1\|> 50.0 ug.mL-1\|= 1.03 ug.mL-1			NPASS
Estradiol 17-beta-dehydrogenase 2	Homo sapiens	P37059		= 360.0 nM			NPASS
Arginase	Leishmaamazonensis			55000 nM			BindingDB
Arginase	Leishmaamazonensis	O96394		= 55000.0 nM			NPASS
Aryl hydrocarbon receptor	Homo sapiens	P35869		28 nM\|= 28.0 nM			BindingDB, NPASS
Aryl sulfotransferase	Rattus norvegicus	P17988		= 290.0 nM			NPASS
Aurora kinase B	Homo sapiens	Q96GD4		4.03e+3 nM			BindingDB
B16	Mus musculus			= 20000.0 nM\|= 53700.0 nM			NPASS
BEAS-2B	Homo sapiens			= 350000.0 nM			NPASS
BGC-823	Homo sapiens			> 10000.0 nM			NPASS
BT-549	Homo sapiens			> 10000.0 nM			NPASS
BV-2	Mus musculus			= 8860.0 nM			NPASS
Beta amyloid A4 protein	Homo sapiens	P05067		= 75100.0 nM			NPASS
Beta-glucuronidase	Homo sapiens	P08236		36470 nM\|= 36470.0 nM			BindingDB, NPASS
Beta-secretase 1	Homo sapiens	P56817		14700 nM\|= 14700.0 nM			BindingDB, NPASS
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens	Q9UNQ0		6200 nM\|4700 nM			BindingDB
Butyrylcholinesterase	Homo sapiens	P06276				= 43100.0 nM	NPASS
CDGSH iron-sulfur domain-containing protein 1	Homo sapiens	Q9NZ45		3100 nM\|= 3100.0 nM		132 nM\|= 132.0 nM	BindingDB, NPASS
CHO-K1	Cricetulus griseus			= 240000.0 nM			NPASS
CWR22R	Homo sapiens			> 40000.0 nM			NPASS
Ca9-22	Homo sapiens			> 20.0 ug.mL-1			NPASS
Arachidonate 5-lipoxygenase	Homo sapiens	P09917		= 2700.0 nM			NPASS
Candida albicans	Candida albicans			> 50.0 ug.mL-1			NPASS
Arachidonate 15-lipoxygenase	Oryctolagus cuniculus	P12530		= 2200.0 nM			NPASS
Androgen Receptor	Homo sapiens	P10275		= 9700.0 nM			NPASS
17-beta-hydroxysteroid dehydrogenase type 1	Homo sapiens	P14061		1050 nM			BindingDB
17-beta-hydroxysteroid dehydrogenase type 2	Homo sapiens	P37059		360 nM			BindingDB
3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum			4000 nM			BindingDB
3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum	Q965D6		= 4000.0 nM			NPASS
A-375	Homo sapiens			= 0.01205 ug.mL-1			NPASS
A549	Homo sapiens			> 100000.0 nM\|> 20.0 ug.mL-1\|> 10000.0 nM			NPASS
ATP-binding cassette sub-family G member 2	Homo sapiens	Q9UNQ0		= 4700.0 nM\|= 6200.0 nM			NPASS
ATP-dependent translocase ABCB1	Homo sapiens	P08183			6761 nM		BindingDB
ATP-dependent translocase ABCB1	Mus musculus	P21447			6700 nM		BindingDB
Acetylcholinesterase	Homo sapiens	P22303				92800 nM\|= 92800.0 nM	BindingDB, NPASS
Acid phosphatase	Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)					1.90e+5 nM	BindingDB
Acidic alpha-glucosidase	Rattus norvegicus	Q6P7A9		= 59540.0 nM			NPASS
Alcohol sulfotransferase	Rattus norvegicus	P15709		= 34000.0 nM			NPASS
Aldo-keto reductase family 1 member B1	Rattus norvegicus	P07943		1330 nM			BindingDB
Aldose reductase	Homo sapiens	P15121		= 10000.0 nM			NPASS
Aldose reductase	Rattus norvegicus	P07943		= 1330.0 nM			NPASS
Alpha-amylase 1A	Homo sapiens	P0DUB6					BindingDB
Alpha-glucosidase MAL62	Saccharomyces cerevisiae	P07265		11995 nM			BindingDB
Amyloid-beta precursor protein	Homo sapiens	P05067		7.51e+4 nM\|75100 nM			BindingDB
Androgen receptor	Homo sapiens	P10275		9700 nM			BindingDB
Carbonic anhydrase 1	Homo sapiens	P00915				>10000 nM	BindingDB
Aldo-keto reductase family 1 member B1	Homo sapiens	P15121		10000 nM			BindingDB
Carbonic anhydrase 2	Homo sapiens	P00918				9526 nM	BindingDB
Cytochrome P450 1A1	Homo sapiens	P04798		632 nM\|= 632.0 nM		750 nM\|= 750.0 nM	BindingDB, NPASS
Cytochrome P450 1A2	Homo sapiens	P05177		716 nM\|= 716.0 nM			BindingDB, NPASS
Cytochrome P450 1B1	Homo sapiens	Q16678		47 nM\|= 47.0 nM		43 nM\|= 43.0 nM	BindingDB, NPASS
Cytochrome P450 2C9	Homo sapiens	P11712				6000 nM\|= 6000.0 nM	BindingDB, NPASS
DNA polymerase eta	Homo sapiens	Q9Y253		= 12700.0 nM			NPASS
Carbonic anhydrase 12	Homo sapiens	O43570				146 nM	BindingDB
Death-associated protein kinase 1	Homo sapiens	P53355		10000 nM\|= 10000.0 nM			BindingDB, NPASS
Dihydroorotate dehydrogenase (fumarate)	Leishmamajor			388900 nM\|398107 nM			BindingDB
Dihydroorotate dehydrogenase (fumarate)	Leishmamajor	Q4QEW7		= 388900.0 nM\|= 398107.17 nM			NPASS
Dipeptidyl peptidase 3	Homo sapiens	Q9NY33		3.29e+4 nM			BindingDB
Dipeptidyl peptidase 4	Homo sapiens	P27487		132000 nM\|490 nM			BindingDB
Dipeptidyl peptidase IV	Homo sapiens	P27487		= 132000.0 nM\|= 490.0 nM\|= 6670.0 nM		= 14430.0 nM	NPASS
E3 ubiquitin-protein ligase XIAP	Homo sapiens	P98170		>100000 nM			BindingDB
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum			20000 nM			BindingDB
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum	Q965D5		= 20000.0 nM			NPASS
Entamoeba histolytica	Eoeba histolytica			= 7.93 ug.mL-1\|= 230.0 nM			NPASS
Epidermal growth factor receptor	Homo sapiens	P00533		10400 nM			BindingDB
Epidermal growth factor receptor erbB1	Homo sapiens	P00533		= 3.0 ug.mL-1			NPASS
Estradiol 17-beta-dehydrogenase 1	Homo sapiens	P14061		= 1050.0 nM			NPASS
Cyclooxygenase-2	Homo sapiens	P35354		> 100000.0 nM			NPASS
Cyclin-dependent kinase 6	Homo sapiens	Q00534		22000 nM\|= 22000.0 nM			BindingDB, NPASS
Cyclooxygenase-1	Homo sapiens	P23219		> 100000.0 nM			NPASS
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1	Homo sapiens	Q9GZU7		9933 nM\|= 9933.0 nM			BindingDB, NPASS
Carbonic anhydrase 7	Homo sapiens	P43166				25 nM	BindingDB
Estrogen-related receptor alpha	Homo sapiens	P11474		= 9640.0 nM			NPASS
Carbonic anhydrase I	Homo sapiens	P00915				> 10000.0 nM	NPASS
Carbonic anhydrase II	Homo sapiens	P00918				= 9525.7 nM	NPASS
Carbonic anhydrase IV	Homo sapiens	P22748				> 10000.0 nM	NPASS
Carbonic anhydrase VII	Homo sapiens	P43166				= 25.0 nM	NPASS
Carbonic anhydrase XII	Homo sapiens	O43570				= 145.9 nM	NPASS
Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Q15078		= 51000.0 nM			NPASS
Casein kinase 2	Homo sapiens			= 400.0 nM		= 210.0 nM	NPASS
Casein kinase 2	Rattus norvegicus			= 400.0 nM			NPASS
Casein kinase II	Homo sapiens	P19784		< 1000.0 nM			NPASS
Casein kinase II subunit alpha 3	Homo sapiens	Q8NEV1		400 nM			BindingDB
Cell division protein kinase 5	Rattus norvegicus	Q03114	= 66100.0 nM				NPASS
Cholinesterase	Homo sapiens	P06276				43100 nM	BindingDB
Cyclin homolog/dependent kinase 6	Saimiriine herpesvirus 2 (strain 11)	Q00534\|Q01043		22000 nM			BindingDB
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B	Marthasterias glacialis	P15206\|Q9DGD3		41000 nM			BindingDB
Cyclin-dependent kinase 1/cyclin B	Homo sapiens	O95067		= 41000.0 nM			NPASS
Cyclin-dependent kinase 5	Rattus norvegicus	Q03114	66100 nM				BindingDB
Cyclin-dependent kinase 5 activator 1 [99-307]	Homo sapiens	Q00535\|Q15078		51000 nM			BindingDB
Carbonic anhydrase 4	Homo sapiens	P22748				>10000 nM	BindingDB

a curated database

IMPPAT Phytochemical information:
Kaempferol

Bioactivity information

IMPPAT Phytochemical information: Kaempferol

Bioactivity information

IMPPAT Phytochemical information:
Kaempferol