IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Insulin receptor	Homo sapiens	P06213		340 nM\|= 340.0 nM			BindingDB, NPASS
Insulin-like growth factor 1 receptor	Homo sapiens	P08069		250 nM			BindingDB
Insulin-like growth factor I receptor	Homo sapiens	P08069		= 250.0 nM			NPASS
Integrase	Human immunodeficiency virus 1			5100 nM			BindingDB
Likely tRNA 2'-phosphotransferase	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)	Q5A7N4		= 540.68 nM			NPASS
M17 leucyl aminopeptidase	Plasmodium falciparum (isolate 3D7)			138080 nM			BindingDB
M17 leucyl aminopeptidase	Plasmodium falciparum 3D7	Q8IL11		= 138080.0 nM			NPASS
MDA-MB-231	Homo sapiens			= 27380.0 nM			NPASS
Marburgvirus	Marburgvirus			= 6400.0 nM			NPASS
Macrophage migration inhibitory factor	Homo sapiens	P14174		4770 nM\|= 4770.0 nM		1950 nM\|= 1950.0 nM	BindingDB, NPASS
Mitogen-activated protein kinase kinase kinase 8	Homo sapiens	P41279		2370 nM\|= 2370.0 nM			BindingDB, NPASS
Monoamine oxidase A	Homo sapiens	P21397	= 1600.0 nM				NPASS
Mothers against decapentaplegic homolog 3	Homo sapiens	P84022		142 nM\|= 142.0 nM			BindingDB, NPASS
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)	Homo sapiens	P06748		> 40000.0 nM			NPASS
NUAK family SNF1-like kinase 1	Homo sapiens	O60285		510 nM\|= 510.0 nM			BindingDB, NPASS
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens	O14920		1980 nM			BindingDB
MIA PaCa-2	Homo sapiens			= 149830.0 nM			NPASS
Inhibitor of nuclear factor kappa B kinase beta subunit	Homo sapiens	O14920		= 1980.0 nM			NPASS
Glutathione S-transferase P	Homo sapiens	P09211		77100 nM			BindingDB
Human immunodeficiency virus type 1 reverse transcriptase	Human immunodeficiency virus 1	Q72547		< 150.0 ug.mL-1			NPASS
Plasmodium falciparum	Plasmodium falciparum			= 0.103 ug.mL-1\|= 0.145 ug.mL-1\|= 330.0 nM\|= 105.0 nM\|= 180.0 nM\|= 351.0 nM\|= 1325.0 nM\|= 819.0 nM\|= 2800.0 nM\|= 8900.0 nM\|= 7500.0 nM			NPASS
Glutathione S-transferase P	Human	P09211		5.0e+4 nM			BindingDB
Glutathione S-transferase Pi	Homo sapiens	P09211		= 77100.0 nM			NPASS
Glutathione reductase	Homo sapiens	P00390		= 22800.0 nM			NPASS
Glutathione reductase, mitochondrial	Homo sapiens	P00390		22800 nM			BindingDB
Glycogen synthase kinase-3 beta	Homo sapiens	P49841		7500 nM\|= 7500.0 nM			BindingDB, NPASS
Guanyl-specific ribonuclease T1	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	P00651		>55688 nM\|> 55688.0 nM			BindingDB, NPASS
Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens	Q07820		54000 nM\|> 54000.0 nM			BindingDB, NPASS
HUVEC	Homo sapiens			> 165000.0 nM			NPASS
Heat shock 70 kDa protein 1A	Homo sapiens	V9GZ37		760 nM\|>100000 nM			BindingDB
Heat shock cognate 71 kDa protein	Homo sapiens	P11142		99200 nM\|= 99200.0 nM\|> 100000.0 nM			BindingDB, NPASS
Heme				= 1200.0 nM			NPASS
Hepatocyte growth factor receptor	Homo sapiens	P08581		580 nM\|= 580.0 nM			BindingDB, NPASS
Histone-arginine methyltransferase CARM1	Homo sapiens	Q86X55		= 25000.0 nM			NPASS
Human immunodeficiency virus type 1 integrase	Human immunodeficiency virus 1	Q7ZJM1		= 5100.0 nM			NPASS
cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma	Homo sapiens	P17612\|P22612\|P22694		3500 nM			BindingDB
Heat shock 70 kDa protein 1	Homo sapiens	P0DMV8		> 100000.0 nM\|= 760.0 nM			NPASS
Plasmodium falciparum (isolate FcB1 / Columbia)	Plasmodium falciparum FcB1/Columbia			= 300.0 nM			NPASS
Serine/threonine-protein kinase PLK1	Homo sapiens	P53350		3340 nM\|= 3340.0 nM			BindingDB, NPASS
Platelet-derived growth factor receptor beta	Homo sapiens	P09619		1300 nM\|= 1300.0 nM			BindingDB, NPASS
Thioredoxin reductase	Homo sapiens	Q86VQ6		= 275300.0 nM\|= 78300.0 nM			NPASS
Translin-associated protein X	Homo sapiens	Q99598		= 3500.0 nM			NPASS
Tyrosine-protein kinase CSK	Rattus norvegicus	P32577		>40000 nM\|> 40000.0 nM			BindingDB, NPASS
Tyrosine-protein kinase FGR	Rattus norvegicus	Q6P6U0		= 9400.0 nM			NPASS
Tyrosine-protein kinase Fgr	Rattus norvegicus	Q6P6U0		9400 nM			BindingDB
Tyrosine-protein kinase Lyn	Rattus norvegicus	Q07014		2900 nM\|= 2900.0 nM			BindingDB, NPASS
Tyrosine-protein kinase SRC	Homo sapiens	P12931		= 300.0 nM\|= 800.0 nM			NPASS
Squalene monooxygenase	Rattus norvegicus	P52020		2000 nM\|= 2000.0 nM			BindingDB, NPASS
Tyrosine-protein kinase SYK	Rattus norvegicus	Q64725		4300 nM\|= 4300.0 nM			BindingDB, NPASS
Tyrosine-protein kinase receptor FLT3	Homo sapiens	P36888		> 40000.0 nM			NPASS
Tyrosine-protein kinase receptor RET	Homo sapiens	P07949		> 40000.0 nM			NPASS
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens	P18031		7730 nM		2800 nM	BindingDB
Vascular endothelial growth factor receptor 2	Homo sapiens	P35968		790 nM\|= 790.0 nM			BindingDB, NPASS
Vascular endothelial growth factor receptor 3	Homo sapiens	P35916		1540 nM\|= 1540.0 nM			BindingDB, NPASS
cAMP-dependent protein kinase (PKA)	Homo sapiens	P22612		= 600.0 nM\|= 3500.0 nM			NPASS
cAMP-dependent protein kinase catalytic subunit alpha	Bos taurus	P00517		600 nM			BindingDB
Tyrosine-protein kinase TIE-2	Homo sapiens	Q02763		= 260.0 nM			NPASS
Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1			= 970.0 nM			NPASS
Sphingosine kinase 1	Homo sapiens	Q9NYA1		740 nM\|= 740.0 nM			BindingDB, NPASS
Serine/threonine-protein kinase PLK4	Homo sapiens	O00444		2970 nM\|= 2970.0 nM			BindingDB, NPASS
Polypeptide N-acetylgalactosaminyltransferase 2	Homo sapiens	Q10471		2930 nM\|510 nM\|= 510.0 nM\|= 2930.0 nM	371 nM\|= 371.0 nM\|= 2367.0 1/Ms\|= 8.79 10'-4/s		BindingDB, NPASS
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens	P12931		300 nM\|800 nM			BindingDB
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens	P07949		>40000 nM			BindingDB
RAC-alpha serine/threonine-protein kinase	Homo sapiens	P31749		3340 nM			BindingDB
RAW264.7	Mus musculus			= 35700.0 nM\|> 50000.0 nM			NPASS
Radical scavenging activity			= 4.8 ug				NPASS
Receptor protein-tyrosine kinase erbB-2	Homo sapiens	P04626		= 3540.0 nM			NPASS
Solute carrier family 22 member 6	Homo sapiens	Q4U2R8		270 nM\|= 270.0 nM			BindingDB, NPASS
Receptor tyrosine-protein kinase erbB-2	Homo sapiens	P04626		3540 nM			BindingDB
Reverse transcriptase	Human immunodeficiency virus 1			<496000 nM			BindingDB
Salmon testes DNA	Oncorhynchus gorbuscha			= 1000.0 nM			NPASS
Serine/threonine-protein kinase AKT	Homo sapiens	P31749		= 3340.0 nM			NPASS
Serine/threonine-protein kinase Aurora-A	Homo sapiens	O14965		= 2480.0 nM			NPASS
Serine/threonine-protein kinase Aurora-B	Homo sapiens	Q96GD4		= 2500.0 nM			NPASS
Serine/threonine-protein kinase B-raf	Homo sapiens	P15056		1760 nM\|= 1760.0 nM			BindingDB, NPASS
Glutathione S-transferase	Plasmodium falciparum	Q8MU52		74400 nM\|= 74400.0 nM			BindingDB, NPASS
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens	P36888		>40000 nM			BindingDB
G-protein coupled receptor 35	Homo sapiens	Q9HC97	110 nM\|2960 nM\|= 110.0 nM\|= 2960.0 nM	100 nM\|= 100.0 nM			BindingDB, NPASS
DNA polymerase eta	Homo sapiens	Q9Y253		62 nM\|= 62.0 nM			BindingDB, NPASS
Filobasidiella neoformans	Cryptococcus neoformans			= 5.5 ug.mL-1			NPASS
Beta-secretase 1	Homo sapiens	P56817		3900 nM\|= 3900.0 nM			BindingDB, NPASS
Bifunctional epoxide hydrolase 2	Homo sapiens	P34913		20700 nM			BindingDB
Candida albicans	Candida albicans			> 50.0 ug.mL-1			NPASS
Carbonic anhydrase 1	Homo sapiens	P00915				207000 nM\|2320 nM\|68200 nM	BindingDB
Carbonic anhydrase 12	Homo sapiens	O43570				10100 nM\|8150 nM	BindingDB
Carbonic anhydrase 13	Homo sapiens	Q8N1Q1				4240 nM	BindingDB
Carbonic anhydrase 13	Mus musculus	Q9D6N1				10300 nM	BindingDB
Carbonic anhydrase 14	Homo sapiens	Q9ULX7				8910 nM	BindingDB
Carbonic anhydrase 2	Homo sapiens	P00918				146000 nM\|2180 nM\|>100000 nM	BindingDB
Carbonic anhydrase 3	Homo sapiens	P07451				10500 nM	BindingDB
Carbonic anhydrase 4	Homo sapiens	P22748				9080 nM	BindingDB
Carbonic anhydrase 5A, mitochondrial	Homo sapiens	P35218				7590 nM	BindingDB
Carbonic anhydrase 5B, mitochondrial	Homo sapiens	Q9Y2D0				12700 nM	BindingDB
Carbonic anhydrase 6	Homo sapiens	P23280				7060 nM	BindingDB
Carbonic anhydrase 7	Homo sapiens	P43166				6320 nM\|8790 nM	BindingDB
Aurora kinase B	Homo sapiens	Q96GD4		2500 nM			BindingDB
Aurora kinase A	Homo sapiens	O14965		2480 nM			BindingDB
Angiotensin-converting enzyme	Homo sapiens	P12821		5000000 nM\|= 5000000.0 nM			BindingDB, NPASS
Angiopoietin-1 receptor	Homo sapiens	Q02763		260 nM			BindingDB
Focal adhesion kinase 1	Homo sapiens	Q05397		3110 nM\|= 3110.0 nM			BindingDB, NPASS
2'-phosphotransferase	Candida albicans (strain SC5314 / ATCC MYA-2876)			540.68 nM			BindingDB
5'-nucleotidase	Homo sapiens	P21589		1850 nM\|= 1850.0 nM			BindingDB, NPASS
5'-nucleotidase	Mus musculus	Q61503		40 nM\|= 40.0 nM			BindingDB, NPASS
ALK tyrosine kinase receptor/Nucleophosmin	Homo sapiens	P06748\|Q9UM73		>40000 nM			BindingDB
Acetyl-CoA acetyltransferase/HMG-CoA reductase	Enterococcus faecalis			1265390 nM			BindingDB
Acetyl-CoA acetyltransferase/HMG-CoA reductase	Enterococcus faecalis	Q9FD70		= 1265390.0 nM			NPASS
Carbonic anhydrase 9	Homo sapiens	Q16790				9370 nM\|79800 nM	BindingDB
Acetylcholinesterase	Electrophorus electricus	O42275		132920 nM\|= 132920.0 nM			BindingDB, NPASS
Aldehyde oxidase 1	Cavia porcellus	H9TB17		1.45e+4 nM		4.53e+3 nM	BindingDB
Aldo-keto reductase family 1 member B1	Homo sapiens	P15121		200 nM			BindingDB
Aldo-keto reductase family 1 member B1	Rattus norvegicus	P07943		200 nM			BindingDB
Aldose reductase	Homo sapiens	P15121		= 200.0 nM			NPASS
Amine oxidase [flavin-containing] A	Homo sapiens	P21397	1600 nM				BindingDB
Amyloid-beta A4 protein	Homo sapiens	P05067	= 6.0 10^3ug/ml\|= 1.7 10^2 ug/ml				NPASS
Amyloid-beta precursor protein	Homo sapiens	P05067	1.7 nM\|6.0 nM	300000 nM\|100000 nM			BindingDB
Acetylcholinesterase	Homo sapiens	P22303		100000 nM			BindingDB
Carbonic anhydrase I	Homo sapiens	P00915				= 2320.0 nM\|= 68200.0 nM	NPASS
Aldose reductase	Rattus norvegicus	P07943		= 199.53 nM			NPASS
Carbonic anhydrase III	Homo sapiens	P07451				= 10500.0 nM	NPASS
DNA gyrase A/A/B/B tetramer	Escherichia coli (strain K12)	P0AES4\|P0AES6		10900 nM\|155000 nM			BindingDB
DNA polymerase iota	Homo sapiens	Q9UNA4		62 nM\|= 62.0 nM			BindingDB, NPASS
DNA primase	Bacillus anthracis			>1.00e+5 nM			BindingDB
Dual specificity protein phosphatase 3	Homo sapiens	P51452		1230 nM\|980 nM\|< 1230.0 nM\|< 980.0 nM			BindingDB, NPASS
Dual specificity protein phosphatase 6	Rattus norvegicus	Q64346		39500 nM\|= 39500.0 nM			BindingDB, NPASS
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens	Q13627		>40000 nM			BindingDB
Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Homo sapiens	Q13627		> 40000.0 nM			NPASS
DNA gyrase	Escherichia coli K-12	P0AES4		= 47.0 ug.mL-1\|= 3.3 ug.mL-1			NPASS
ELAV-like protein 3	Homo sapiens	Q14576		600 nM\|= 600.0 nM			BindingDB, NPASS
Ephrin type-B receptor 4	Homo sapiens	P54760		1830 nM\|= 1830.0 nM			BindingDB, NPASS
Epidermal growth factor receptor	Homo sapiens	P00533		690 nM			BindingDB
Epidermal growth factor receptor erbB1	Homo sapiens	P00533		= 690.0 nM			NPASS
Epoxide hydratase	Homo sapiens	P34913		= 20700.0 nM			NPASS
Erythrocyte				= 320000.0 nM			NPASS
Carbonic anhydrase II	Homo sapiens	P00918				= 2180.0 nM\|> 100000.0 nM	NPASS
Eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	Q04637		47671.37474 nM			BindingDB
Ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	P55772		500 nM\|= 500.0 nM			BindingDB, NPASS
Cysteine protease ATG4B	Homo sapiens	Q9Y4P1		5500 nM\|3000 nM\|= 5500.0 nM\|= 3000.0 nM			BindingDB, NPASS
Ebolavirus	Ebolavirus			= 1400.0 nM			NPASS
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1	Homo sapiens	P11802\|P24385		1090 nM			BindingDB
Carbonic anhydrase IX	Homo sapiens	Q16790				= 9370.0 nM\|= 79800.0 nM	NPASS
Cyclin-dependent kinase 4/cyclin D1	Homo sapiens	P24385		= 1090.0 nM			NPASS
Carbonic anhydrase VA	Homo sapiens	P35218				= 7590.0 nM	NPASS
Carbonic anhydrase VB	Homo sapiens	Q9Y2D0				= 12700.0 nM	NPASS
Carbonic anhydrase VI	Homo sapiens	P23280				= 7060.0 nM	NPASS
Carbonic anhydrase XII	Homo sapiens	O43570				= 10100.0 nM\|= 8150.0 nM	NPASS
Carbonic anhydrase XIII	Homo sapiens	Q8N1Q1				= 4240.0 nM	NPASS
Carbonic anhydrase XIII	Mus musculus	Q9D6N1				= 10300.0 nM	NPASS
Carbonic anhydrase VII	Homo sapiens	P43166				= 6320.0 nM\|= 8790.0 nM	NPASS
Casein kinase II	Homo sapiens	P19784		= 40.0 nM			NPASS
Casein kinase II alpha	Homo sapiens	P68400		= 40.0 nM		= 20.0 nM	NPASS
Casein kinase II subunit alpha	Homo sapiens	P68400		40 nM		20 nM	BindingDB
Carbonic anhydrase IV	Homo sapiens	P22748				= 9080.0 nM	NPASS
Cruzipain	Trypanosoma cruzi	P25779		220000 nM\|= 64000.0 nM\|= 220000.0 nM			BindingDB, NPASS
Carbonic anhydrase XIV	Homo sapiens	Q9ULX7				= 8910.0 nM	NPASS
Cyclin-dependent kinase 2/cyclin A	Homo sapiens	P78396		= 3390.0 nM			NPASS
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2	Homo sapiens	P20248\|P24941\|P78396		3390 nM			BindingDB

a curated database

IMPPAT Phytochemical information:
Ellagic acid

Bioactivity information

IMPPAT Phytochemical information: Ellagic acid

Bioactivity information

IMPPAT Phytochemical information:
Ellagic acid