IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Plasmodium falciparum	Plasmodium falciparum		= 1419.0 nM	= 5200.0 nM\|= 3440.0 nM\|= 12780.0 nM			NPASS
Nonstructural protein 5	Dengue virus	V5TFZ2		= 1700.0 nM			NPASS
Nuclear factor NF-kappa-B p65 subunit	Homo sapiens	Q04206		> 10000.0 nM			NPASS
OVCAR-3	Homo sapiens			= 0.9 ug.mL-1\|= 59000.0 nM\|= 40000.0 nM\|= 8366.0 nM			NPASS
Oxysterols receptor LXR-alpha	Homo sapiens	Q13133	>50000 nM				BindingDB
Oxysterols receptor LXR-beta	Homo sapiens	P55055	>50000 nM				BindingDB
PA-1	Homo sapiens			= 11.53 ug.mL-1			NPASS
PANC-1	Homo sapiens			= 44000.0 nM			NPASS
PC-3	Homo sapiens		= 1900000.0 nM	= 91000.0 nM\|= 40000.0 nM\|= 21500.0 nM\|= 37000.0 nM\|> 10000.0 nM			NPASS
Pancreatic alpha-amylase	Sus scrofa	P00690		>200000 nM\|> 200000.0 nM			BindingDB, NPASS
Peroxisome proliferator-activated receptor gamma	Mus musculus	P37238	>100000 nM\|> 100000.0 nM				BindingDB, NPASS
Phosphodiesterase isozyme 4	Homo sapiens	Q86V67		= 125000.0 nM			NPASS
P815	Mus musculus			= 41000.0 nM			NPASS
NON-PROTEIN TARGET			= 11900.0 nM\|= 9400.0 nM\|= 4300.0 nM	= 92070.0 nM\|> 20000.0 nM\|= 61000.0 nM\|= 21000.0 nM\|= 1.7 ug.mL-1\|= 32000.0 nM\|> 50000.0 nM\|= 42000.0 nM\|= 9700.0 nM\|= 11100.0 nM\|= 11900.0 nM\|= 8130.0 nM\|= 9180.0 nM\|= 12070.0 nM\|= 29000.0 nM\|= 21270.0 nM\|= 19450.0 nM\|= 3610.0 nM\|= 14800.0 nM\|= 27510.0 nM\|= 22130.0 nM\|= 10223.0 nM\|= 8000.0 nM\|= 7000.0 nM\|= 5900.0 nM			NPASS
NIH3T3	Mus musculus		= 13100.0 nM\|= 16100.0 nM\|= 12900.0 nM\|> 30000.0 nM	= 4.37 ug.mL-1\|= 10000.0 nM			NPASS
MRC5	Homo sapiens			= 32800.0 nM			NPASS
MIA PaCa-2	Homo sapiens			> 20.0 ug.mL-1\|> 10000.0 nM\|= 26700.0 nM			NPASS
MDA-MB-231	Homo sapiens			= 3.5 ug.mL-1\|= 15240.0 nM\|= 34570.0 nM\|> 20000.0 nM\|> 500000.0 nM\|> 10000.0 nM\|> 40000.0 nM\|= 19130.0 nM			NPASS
MCF7	Homo sapiens		= 14900.0 nM\|= 10200.0 nM\|= 14800.0 nM\|= 11400.0 nM\|= 10600.0 nM\|= 12000.0 nM\|> 30000.0 nM	= 143000.0 nM\|= 41000.0 nM\|= 50000.0 nM\|= 4.0 ug.mL-1\|= 14900.0 nM\|= 12270.0 nM\|= 30000.0 nM\|= 14800.0 nM\|= 37000.0 nM\|= 14030.0 nM\|= 22610.0 nM\|= 10527.0 nM\|> 10000.0 nM\|= 56300.0 nM\|> 25000.0 nM\|= 330.0 nM\|> 40000.0 nM			NPASS
M14	Homo sapiens			= 50000.0 nM			NPASS
Leishmania donovani	Leishmadonovani			= 2600.0 nM\|= 4100.0 nM			NPASS
LXR-beta	Homo sapiens	P55055	> 50000.0 nM				NPASS
LXR-alpha	Homo sapiens	Q13133	> 50000.0 nM				NPASS
L02	Homo sapiens			= 35070.0 nM			NPASS
KB	Homo sapiens			= 27500.0 nM\|= 28100.0 nM\|= 28700.0 nM			NPASS
K562	Homo sapiens			= 112000.0 nM\|= 56000.0 nM\|= 3.25 ug.mL-1\|= 21960.0 nM			NPASS
Jurkat	Homo sapiens			= 26.9 nM\|= 26900.0 nM			NPASS
J774	Mus musculus			= 44000.0 nM			NPASS
Protease	Human immunodeficiency virus 1			4000 nM			BindingDB
Serum albumin	Homo sapiens	P02768			= 4500.0 nM\|= 1300.0 nM\|= 593.0 nM		NPASS
Protein kinase C epsilon	Homo sapiens	Q02156		> 150000.0 nM			NPASS
Influenza A virus	InflueA virus		> 219000.0 nM				NPASS
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [559-660]	Homo sapiens	Q86V67 P27815		125000 nM			BindingDB
Zinc finger protein GLI1	Homo sapiens	P08151		32000 nM\|= 32000.0 nM			BindingDB, NPASS
WI-38 VA13	Homo sapiens			= 11600.0 nM			NPASS
Vesicular stomatitis Indiana virus	Vesicular stomatitis Indiana virus		= 159690.0 nM				NPASS
Vero	Chlorocebus aethiops			= 72100.0 nM			NPASS
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens	P18031		1500 nM			BindingDB
Trypanosoma brucei brucei	Trypanosoma brucei brucei			= 32600.0 nM			NPASS
Trichostrongylus colubriformis	Trichostrongylus colubriformis			= 180000.0 nM			NPASS
Transcription factor p65	Homo sapiens	Q04206		>10000 nM			BindingDB
THP-1	Homo sapiens			= 20000.0 nM			NPASS
T47D	Homo sapiens			= 15560.0 nM			NPASS
Sindbis virus	Sindbis virus			= 457.09 nM\|= 500.0 nM			NPASS
Protein kinase C beta	Homo sapiens	P05771		> 150000.0 nM			NPASS
SiHa	Homo sapiens			= 70100.0 nM			NPASS
SW948	Homo sapiens			= 10500.0 nM			NPASS
SW480	Homo sapiens			= 6400.0 nM\|= 6480.0 nM			NPASS
SW-620	Homo sapiens			= 13.26 ug.mL-1			NPASS
SW-1736	Homo sapiens		= 16400.0 nM\|= 18300.0 nM\|= 14800.0 nM	= 11600.0 nM\|= 13090.0 nM			NPASS
SUMO-activating enzyme subunit 1	Homo sapiens	Q9UBE0		9240 nM			BindingDB
SUMO-activating enzyme	Homo sapiens	Q9UBT2		= 9240.0 nM\|= 13160.0 nM			NPASS
SK-OV-3	Homo sapiens			= 17680.0 nM\|> 10000.0 nM			NPASS
SK-MEL-2	Homo sapiens		= 2200000.0 nM	= 21000.0 nM\|= 33000.0 nM\|= 17440.0 nM\|= 7000.0 nM\|> 10000.0 nM			NPASS
SK-MEL	Homo sapiens			= 35000.0 nM			NPASS
SF-295	Homo sapiens			= 22000.0 nM			NPASS
SARS coronavirus	SARS coronavirus		> 10000.0 nM				NPASS
RAW264.7	Mus musculus			= 42500.0 nM\|= 32380.0 nM\|> 100000.0 nM			NPASS
Protein-tyrosine phosphatase 1B	Homo sapiens	P18031		= 1500.0 nM			NPASS
Semliki forest virus	Semliki forest virus			= 14600.0 nM\|= 14454.4 nM			NPASS
Hypoxia-inducible factor prolyl hydroxylase	Homo sapiens		> 50000.0 nM				NPASS
H9	Homo sapiens		= 1400.0 nM	= 13000.0 nM\|= 12900.0 nM			NPASS
Human immunodeficiency virus 1	Human immunodeficiency virus 1		= 1400.0 nM\|= 899.5 nM\|= 1399.59 nM	= 12900.0 nM\|= 32500.0 nM\|= 3100.0 nM\|= 5315.0 nM			NPASS
DNA polymerase beta	Homo sapiens	P06746		33700 nM\|46250 nM\|43600 nM\|= 33700.0 nM\|= 46250.0 nM\|= 43600.0 nM			BindingDB, NPASS
DLD-1	Homo sapiens			= 15000.0 nM\|> 200000.0 nM\|= 17500.0 nM\|= 11870.0 nM			NPASS
Candida albicans	Candida albicans			> 50.0 ug.mL-1			NPASS
Caenorhabditis elegans	Caenorhabditis elegans			= 150000.0 nM			NPASS
Ca9-22	Homo sapiens			> 20.0 ug.mL-1			NPASS
CHO	Cricetulus griseus			> 20000.0 nM			NPASS
CCRF-CEM	Homo sapiens			= 30000.0 nM\|= 27000.0 nM			NPASS
C6	Rattus norvegicus			= 90690.0 nM			NPASS
Botulinum neurotoxin type A	Clostridium botulinum	P10845		= 20000.0 nM		= 14300.0 nM	NPASS
Botulinum neurotoxin type A	Clostridium botulinum	P0DPI0		20000 nM		14300 nM	BindingDB
Bile acid receptor FXR	Homo sapiens	Q96RI1	= 0.0 nM				NPASS
Bel-7402	Homo sapiens			= 43390.0 nM			NPASS
BV-2	Mus musculus			= 4500.0 nM			NPASS
B16	Mus musculus			= 53460.0 nM\|= 7900.0 nM\|= 5.0 ug.mL-1			NPASS
Aldose reductase	Homo sapiens	P15121		= 11000.0 nM			NPASS
Aldo-keto reductase family 1 member B10	Homo sapiens	O60218		2000 nM\|= 2000.0 nM			BindingDB, NPASS
Aldo-keto reductase family 1 member B1	Homo sapiens	P15121		11000 nM			BindingDB
Albumin	Homo sapiens	P02768			4500 nM\|593 nM\|1300 nM		BindingDB
A549	Homo sapiens		= 14800.0 nM\|= 17100.0 nM\|= 14900.0 nM\|= 7600.0 nM	= 97510.0 nM\|= 6650.0 nM\|= 146000.0 nM\|= 3.0 ug.mL-1\|= 10300.0 nM\|= 72800.0 nM\|= 85300.0 nM\|= 2.8 ug.mL-1\|> 200000.0 nM\|= 14900.0 nM\|= 10820.0 nM\|= 11100.0 nM\|= 31000.0 nM\|= 43970.0 nM\|= 13300.0 nM\|> 20000.0 nM\|= 8000.0 nM\|= 17130.0 nM\|> 10000.0 nM\|= 43700.0 nM\|= 3100.0 nM\|= 330.0 nM\|= 29500.0 nM			NPASS
A2780	Homo sapiens		= 11000.0 nM\|= 8800.0 nM\|= 12700.0 nM\|= 9700.0 nM\|> 30000.0 nM	>= 20.0 ug.mL-1\|= 11000.0 nM\|= 11070.0 nM\|= 8750.0 nM\|= 330.0 nM			NPASS
A-431	Homo sapiens			= 15400.0 nM\|= 12600.0 nM			NPASS
A-375	Homo sapiens		= 12000.0 nM\|= 17100.0 nM\|> 30000.0 nM	= 51000.0 nM\|= 22000.0 nM\|= 43700.0 nM			NPASS
Human immunodeficiency virus type 1 protease	Human immunodeficiency virus 1	Q72874		> 219000.0 nM			NPASS
518A2	Homo sapiens		= 13600.0 nM\|= 9400.0 nM\|= 11900.0 nM	= 330.0 nM			NPASS
5'-nucleotidase	Mus musculus	Q61503		= 68790.0 nM			NPASS
5'-nucleotidase	Homo sapiens	P21589		= 7280.0 nM			NPASS
4T1	Mus musculus			= 14040.0 nM			NPASS
DNA polymerase beta	Rattus norvegicus	P06766		14000 nM\|6500 nM\|= 14000.0 nM\|= 6500.0 nM			BindingDB, NPASS
DU-145	Homo sapiens			= 196000.0 nM\|> 20.0 ug.mL-1\|= 37000.0 nM\|= 22000.0 nM\|= 36160.0 nM\|> 500000.0 nM			NPASS
8505C	Homo sapiens		= 6700.0 nM	= 6700.0 nM\|= 7260.0 nM\|= 12630.0 nM\|= 330.0 nM			NPASS
Dengue virus	Dengue virus			= 1700.0 nM			NPASS
Human herpesvirus 1 strain KOS	Human herpesvirus 1 strain KOS			= 700.0 nM			NPASS
Human herpesvirus 1	Human herpesvirus 1		= 8200.0 nM				NPASS
Homo sapiens	Homo sapiens			= 577000.0 nM			NPASS
HepG2	Homo sapiens			= 3.1 ug.mL-1\|= 36.4 nM\|= 36400.0 nM\|= 23900.0 nM\|= 25300.0 nM			NPASS
HeLa	Homo sapiens		= 8800.0 nM	= 0.8 ug.mL-1\|= 26.0 nM\|= 26000.0 nM\|= 47600.0 nM			NPASS
Haemonchus contortus	Haemonchus contortus			= 110000.0 nM			NPASS
HT-29	Homo sapiens		= 13100.0 nM\|= 14400.0 nM\|= 18400.0 nM\|= 16000.0 nM\|> 30000.0 nM	= 89000.0 nM\|= 37000.0 nM\|= 16100.0 nM\|= 13930.0 nM\|= 12800.0 nM\|= 31000.0 nM\|= 17320.0 nM\|> 10000.0 nM\|= 3500.0 nM			NPASS
HL-60	Homo sapiens			= 2.0 ug.mL-1\|= 17000.0 nM\|= 18470.0 nM			NPASS
HEp-2	Homo sapiens			= 16000.0 nM\|> 500000.0 nM			NPASS
HCT-8	Homo sapiens			= 17800.0 nM\|= 13100.0 nM			NPASS
HCT-15	Homo sapiens			= 14250.0 nM\|= 12000.0 nM\|= 8700.0 nM			NPASS
HCT-116	Homo sapiens			= 13300.0 nM\|= 13460.0 nM\|= 10800.0 nM\|> 10000.0 nM			NPASS
HBL-100	Homo sapiens			= 5.02 ug.mL-1			NPASS
HEK293	Homo sapiens			= 336200.0 nM			NPASS
Glycogen phosphorylase, muscle form	Oryctolagus cuniculus	P00489		43000 nM\|= 43000.0 nM\|= 42657.95 nM			BindingDB, NPASS
Dipeptidyl peptidase IV	Homo sapiens	P27487		= 55820.0 nM			NPASS
ECa-109 cell line				= 28070.0 nM			NPASS
Egl nine homolog 1/Prolyl hydroxylase EGLN2/Prolyl hydroxylase EGLN3/Transmembrane prolyl 4-hydroxylase	Homo sapiens	Q96KS0\|Q9GZT9\|Q9H6Z9\|Q9NXG6	>50000 nM				BindingDB
Ehrlich	Mus musculus			= 54000.0 nM			NPASS
Env polyprotein	Human immunodeficiency virus 1		>100000 nM				BindingDB
FaDu	Homo sapiens		= 15300.0 nM\|= 13700.0 nM\|= 13400.0 nM\|= 10700.0 nM\|> 30000.0 nM	= 10400.0 nM\|= 10190.0 nM			NPASS
ECV-304	Homo sapiens			= 1.2 ug.mL-1\|= 1.26 ug.mL-1			NPASS
G-protein coupled bile acid receptor 1	Homo sapiens	Q8TDU6	1040 nM\|= 1040.0 nM				BindingDB, NPASS
Filobasidiella neoformans	Cryptococcus neoformans			> 50.0 ug.mL-1			NPASS
Genome polyprotein	Dengue virus			1700 nM			BindingDB
Daoy	Homo sapiens			= 31000.0 nM\|= 11000.0 nM			NPASS
GP41	Human immunodeficiency virus 1	Q76270	> 100000.0 nM				NPASS
Gag-Pol polyprotein [489-587]	Human immunodeficiency virus 1	P04585		>219000 nM			BindingDB

a curated database

IMPPAT Phytochemical information:
Betulinic acid

Bioactivity information

IMPPAT Phytochemical information: Betulinic acid

Bioactivity information

IMPPAT Phytochemical information:
Betulinic acid