IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Serotonin 1b (5-HT1b) receptor	Homo sapiens	P28222				= 36.0 nM	NPASS
Serotonin 1a (5-HT1a) receptor	Rattus norvegicus	P19327				= 170.0 nM\|= 169.82 nM	NPASS
Saccharomyces cerevisiae	Saccharomyces cerevisiae		= 300000.0 nM				NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM			NPASS
Norepinephrine transporter	Rattus norvegicus	Q9WTR4	= 716.0 nM				NPASS
MCF7	Homo sapiens			> 50000.0 nM			NPASS
Myeloperoxidase	Homo sapiens	P05164		770 nM\|= 770.0 nM			BindingDB, NPASS
MDA-MB-231	Homo sapiens			> 50000.0 nM			NPASS
Serotonin 1b (5-HT1b) receptor	Rattus norvegicus	P28564				= 10200.0 nM	NPASS
Indoleamine 2,3-dioxygenase 1	Homo sapiens	P14902				160000 nM	BindingDB
Indoleamine 2,3-dioxygenase	Homo sapiens	P14902				= 160000.0 nM\|= 156000.0 nM	NPASS
NON-PROTEIN TARGET				= 682000.0 nM\|= 6000.0 nM\|= 31800.0 nM\|= 10400.0 nM			NPASS
Serotonin 1d (5-HT1d) receptor	Homo sapiens	P28221				= 23.0 nM\|= 61.0 nM	NPASS
Serotonin 2c (5-HT2c) receptor	Homo sapiens	P28335				= 50.0 nM	NPASS
Serotonin 2 (5-HT2) receptor	Rattus norvegicus	P14842				= 2895.0 nM\|= 50.0 nM	NPASS
Serotonin 2a (5-HT2a) receptor	Homo sapiens	P28223	= 7.36 nM				NPASS
Serotonin 2b (5-HT2b) receptor	Rattus norvegicus	P30994			= 537.03 nM		NPASS
Serotonin 6 (5-HT6) receptor	Homo sapiens	P50406				= 180.0 nM\|= 70.0 nM	NPASS
Serotonin 7 (5-HT7) receptor	Homo sapiens	P34969				= 158.49 nM	NPASS
Serotonin transporter	Rattus norvegicus	P31652	= 32.6 nM				NPASS
Sodium-dependent dopamine transporter	Rattus norvegicus	P23977	164 nM				BindingDB
Sodium-dependent serotonin transporter	Rattus norvegicus	P31652	33 nM				BindingDB
Trace amine-associated receptor 1	Homo sapiens	Q96RJ0	2210 nM\|= 2210.0 nM			1084 nM	BindingDB, NPASS
Trace amine-associated receptor 1	Rattus norvegicus	Q923Y9	310 nM\|= 310.0 nM				BindingDB, NPASS
Transporter	Rattus norvegicus		716 nM				BindingDB
n.a.				= 672000.0 nM			NPASS
Dopamine transporter	Rattus norvegicus	P23977	= 164.0 nM				NPASS
Serotonin 2 (5-HT2) receptor	Rattus norvegicus	P08909\|P14842\|P30994				2895 nM\|50 nM	BindingDB
Cytochrome P450 2A6	Homo sapiens	P11509			2300 nM\|= 2300.0 nM	1700 nM\|= 1700.0 nM	BindingDB, NPASS
5-hydroxytryptamine receptor 2C	Rattus norvegicus	P08909				56.23 nM\|62 nM\|772 nM	BindingDB
Cathepsin K	Homo sapiens	P43235		15000 nM\|= 15000.0 nM			BindingDB, NPASS
5-hydroxytryptamine 1D receptor	Bos taurus					40 nM	BindingDB
5-hydroxytryptamine receptor 1A	Homo sapiens	P08908				104.71 nM	BindingDB
5-hydroxytryptamine receptor 1A	Rattus norvegicus	P19327				3715.35 nM\|>10000 nM\|170 nM	BindingDB
5-hydroxytryptamine receptor 1B	Homo sapiens	P28222				86 nM\|524.8 nM\|36 nM	BindingDB
5-hydroxytryptamine receptor 1B	Rattus norvegicus	P28564				10200 nM	BindingDB
5-hydroxytryptamine receptor 1D	Canis lupus familiaris	P11614				346.73 nM	BindingDB
5-hydroxytryptamine receptor 1D	Homo sapiens	P28221				521 nM\|85.11 nM\|61 nM\|23 nM	BindingDB
5-hydroxytryptamine receptor 1E	Homo sapiens	P28566				2559 nM	BindingDB
5-hydroxytryptamine receptor 2A	Homo sapiens	P28223	7.4 nM			89.12 nM\|3162.27 nM\|588.84 nM\|257.04 nM\|218.78 nM	BindingDB
5-hydroxytryptamine receptor 2A	Rattus norvegicus	P14842				11 nM\|2932 nM\|1682 nM\|538 nM\|25.11 nM\|3890.45 nM\|>10000 nM\|416.86 nM	BindingDB
5-hydroxytryptamine receptor 2A	Sus scrofa	P50129				3394 nM	BindingDB
5-hydroxytryptamine receptor 2B	Bos taurus					1300 nM	BindingDB
5-hydroxytryptamine receptor 2B	Homo sapiens	P41595				73.2 nM\|25.11 nM\|29.51 nM\|102.33 nM	BindingDB
5-hydroxytryptamine receptor 1F	Homo sapiens	P30939				2409 nM	BindingDB
5-hydroxytryptamine receptor 2B	Rattus norvegicus	P30994			537.03 nM	199.52 nM\|112.2 nM\|113 nM	BindingDB
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor	Rattus norvegicus	P19328\|P22086\|P22909				19000 nM	BindingDB
5-hydroxytryptamine receptor 2B	Mus musculus	Q02152				199.52 nM	BindingDB
5-hydroxytryptamine receptor 7	Rattus norvegicus	P32305				33.11 nM\|16.21 nM\|32.8 nM\|16.4 nM	BindingDB
5-hydroxytryptamine receptor 7	Homo sapiens	P34969				147.91 nM\|149 nM\|158 nM	BindingDB
5-hydroxytryptamine receptor 7	Cavia porcellus	P50407				64.56 nM\|19.05 nM	BindingDB
5-hydroxytryptamine receptor 6	Rattus norvegicus	P31388				438 nM\|158.48 nM\|1479.1 nM	BindingDB
Adrenergic receptor alpha-2	Rattus norvegicus	P22909				= 19000.0 nM	NPASS
5-hydroxytryptamine receptor 4	Mus musculus	P97288				>10000 nM	BindingDB
5-hydroxytryptamine receptor 2C	Sus scrofa					79.43 nM	BindingDB
Cytochrome P450 2A13	Homo sapiens	Q16696			5200 nM\|= 5200.0 nM	16000 nM\|= 16000.0 nM	BindingDB, NPASS
5-hydroxytryptamine receptor 2C	Homo sapiens	P28335				3000 nM\|295.12 nM\|45.71 nM\|2344.23 nM\|50 nM	BindingDB
5-hydroxytryptamine receptor 6	Homo sapiens	P50406				438 nM\|180 nM\|70 nM	BindingDB

a curated database

IMPPAT Phytochemical information:
Tryptamine

Bioactivity information

IMPPAT Phytochemical information: Tryptamine

Bioactivity information

IMPPAT Phytochemical information:
Tryptamine