IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Nitric oxide synthase, inducible	Homo sapiens	P35228		>40000 nM\|> 40000.0 nM			BindingDB, NPASS
Nuclear factor NF-kappa-B p65 subunit	Homo sapiens	Q04206		= 2400.0 nM			NPASS
Nuclear factor erythroid 2-related factor 2	Homo sapiens	Q16236	>= 18900.0 nM				NPASS
OVCAR-3	Homo sapiens			> 10000.0 nM			NPASS
Ovis aries	Ovis aries			= 76600.0 nM			NPASS
PANC-1	Homo sapiens			= 362800.0 nM			NPASS
PC-12	Rattus norvegicus		= 8550.0 nM				NPASS
Phosphotyrosine protein phosphatase	Mycobacterium tuberculosis	A0A045ISB3		= 22100.0 nM\|= 14000.0 nM\|= 22000.0 nM			NPASS
PC-3	Homo sapiens			= 211000.0 nM\|= 6510.0 nM\|> 100000.0 nM\|> 30000.0 nM			NPASS
Pancreatic alpha-amylase	Sus scrofa	P00690		94100 nM\|= 94100.0 nM			BindingDB, NPASS
Pancreatic triacylglycerol lipase	Sus scrofa	P00591		181000 nM\|= 83.0 ug.mL-1			BindingDB, NPASS
Phospholipase A2	Homo sapiens	P04054		3000 nM			BindingDB
Phospholipase A2 group 1B	Homo sapiens	P04054		= 3000.0 nM			NPASS
NON-PROTEIN TARGET			> 30000.0 nM\|= 64300.0 nM	> 5000.0 nM\|= 165000.0 nM\|> 150000.0 nM\|> 50000.0 nM\|= 18520.0 nM\|> 40000.0 nM\|> 60000.0 nM\|> 100000.0 nM\|= 57890.0 nM\|= 54560.0 nM\|= 23740.0 nM\|= 72740.0 nM\|= 106400.0 nM			NPASS
NIH3T3	Mus musculus		> 30000.0 nM\|= 57900.0 nM\|= 76400.0 nM	= 76400.0 nM\|> 10000.0 nM			NPASS
MGC-803	Homo sapiens			> 200000.0 nM			NPASS
NCI-N87	Homo sapiens			> 10000.0 nM			NPASS
M14	Homo sapiens			= 82000.0 nM			NPASS
MCF-12A	Homo sapiens			> 50000.0 nM			NPASS
MCF7	Homo sapiens		> 30000.0 nM\|= 80000.0 nM\|= 49100.0 nM	> 150000.0 nM\|= 35400.0 nM\|> 60000.0 nM\|> 100000.0 nM\|= 12600.0 nM\|> 10000.0 nM\|> 500000.0 nM\|= 12700.0 nM\|> 200000.0 nM\|= 4.23 nM			NPASS
MDA-MB-231	Homo sapiens			> 100000.0 nM\|= 67870.0 nM\|= 134000.0 nM\|> 10000.0 nM\|= 512400.0 nM\|> 50000.0 nM			NPASS
MDA-MB-435	Homo sapiens			> 10000.0 nM			NPASS
MDA-MB-453	Homo sapiens			> 100000.0 nM			NPASS
NCI/ADR-RES	Homo sapiens			> 200000.0 nM			NPASS
MDA-MB-468	Homo sapiens			= 38100.0 nM			NPASS
MRC5	Homo sapiens			> 10000.0 nM			NPASS
Mus musculus	Mus musculus			> 40000.0 nM\|= 40000.0 nM			NPASS
Mycobacterium tuberculosis H37Ra	Mycobacterium tuberculosis H37Ra			= 214000.0 nM			NPASS
NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens	Q9NXA8		70000 nM\|= 70000.0 nM			BindingDB, NPASS
NCI-H1975	Homo sapiens			> 10000.0 nM			NPASS
NCI-H460	Homo sapiens			> 100000.0 nM			NPASS
Plasmodium falciparum	Plasmodium falciparum			= 26240.0 nM\|= 23810.0 nM			NPASS
Prostaglandin G/H synthase 1	Homo sapiens	P23219		380000 nM			BindingDB
Receptor-type tyrosine-protein phosphatase F	Homo sapiens	P10586		>120000 nM\|22310 nM\|11800 nM			BindingDB
Prostaglandin G/H synthase 2	Homo sapiens	P35354		295000 nM\|>40000 nM			BindingDB
Tissue factor	Homo sapiens	P13726		5 nM			BindingDB
Toxoplasma gondii	Toxoplasma gondii			= 54800.0 nM			NPASS
Transcription factor p65	Homo sapiens	Q04206		2400 nM			BindingDB
Trypanosoma brucei brucei	Trypanosoma brucei brucei			= 6400.0 nM\|= 43100.0 nM			NPASS
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens	P18031		1.90e+3 nM\|1.95e+3 nM\|1860 nM\|1030 nM\|3020 nM\|2560 nM\|1000 nM\|1536 nM\|9500 nM\|700 nM\|730 nM\|2300 nM\|2390000 nM\|1100 nM\|3840 nM\|3480 nM\|3900 nM\|7600 nM\|5600 nM\|2000 nM\|3320 nM\|2058 nM\|2600 nM\|2010 nM\|2500 nM\|5050 nM\|1620 nM\|2690 nM\|4300 nM\|40700 nM\|2960 nM\|3300 nM\|500 nM\|2950 nM		6000 nM	BindingDB
Tyrosine-protein phosphatase non-receptor type 1 [1-321]	Homo sapiens	P18031				4000 nM	BindingDB
TYR_PHOSPHATASE_2 domain-containing protein	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)			22100 nM\|14000 nM\|22000 nM			BindingDB
Tyrosine-protein phosphatase non-receptor type 1 [1-405]	Homo sapiens	P18031				2000 nM	BindingDB
Tyrosine-protein phosphatase non-receptor type 2	Homo sapiens	P17706		4.23e+3 nM\|12000 nM\|5460 nM\|>120000 nM\|1600 nM\|7860 nM\|5000 nM\|4890 nM\|6420 nM\|10550 nM\|700 nM\|2950 nM			BindingDB
Tyrosine-protein phosphatase non-receptor type 6	Homo sapiens	P29350		>120000 nM\|14190 nM			BindingDB
Ubiquitin carboxyl-terminal hydrolase 7	Homo sapiens	Q93009		= 12500.0 nM			NPASS
Vero	Chlorocebus aethiops			> 250000.0 nM\|> 500000.0 nM			NPASS
WI-38 VA13	Homo sapiens			= 123000.0 nM			NPASS
Lu1	Homo sapiens			> 100000.0 nM			NPASS
Tyrosine-protein phosphatase non-receptor type 11	Homo sapiens	Q06124		>120000 nM\|11620 nM			BindingDB
Prostaglandin G/H synthase 1	Ovis aries	P05979		42000 nM			BindingDB
T47D	Homo sapiens			= 36220.0 nM			NPASS
T-24	Homo sapiens			= 66860.0 nM			NPASS
Protease	Human immunodeficiency virus 1			21800 nM\|4000 nM\|8000 nM\|57700 nM			BindingDB
Protease	Human immunodeficiency virus 1	Q9YQ12		= 10.0 ug.mL-1\|= 8000.0 nM\|= 57700.0 nM			NPASS
Protein-tyrosine phosphatase 1B	Homo sapiens	P18031		= 3900.0 nM\|= 7600.0 nM\|= 3370.0 nM\|= 4200.0 nM\|= 3840.0 nM\|= 5600.0 nM\|= 9500.0 nM\|= 5050.1 nM\|= 2600.0 nM\|= 1100.0 nM\|= 1.17 ug.mL-1\|= 3020.0 nM\|= 2010.0 nM\|= 1900.0 nM\|= 0.85 ug.mL-1\|= 1030.0 nM\|= 1170.0 nM\|= 1000.0 nM\|= 1536.0 nM\|= 700.0 nM\|= 730.0 nM\|= 2300.0 nM\|= 2390000.0 nM\|= 3480.0 nM\|= 2000.0 nM\|= 3320.0 nM\|= 2058.0 nM\|= 2500.0 nM\|= 1620.0 nM\|= 2690.0 nM\|= 4300.0 nM\|= 40700.0 nM\|= 2960.0 nM\|= 3300.0 nM\|= 990.0 nM\|= 2950.0 nM\|= 500.0 nM		= 6000.0 nM	NPASS
Protein-tyrosine phosphatase 1C	Homo sapiens	P29350		= 31330.0 nM\|> 120000.0 nM\|= 14190.0 nM			NPASS
Protein-tyrosine phosphatase 2C	Homo sapiens	Q06124		> 120000.0 nM\|= 11620.0 nM			NPASS
RAW264.7	Mus musculus			= 41700.0 nM\|= 89120.0 nM\|= 96630.0 nM			NPASS
Z-138	Homo sapiens			> 100000.0 nM			NPASS
Receptor-type tyrosine-protein phosphatase C	Homo sapiens	P08575		1000 nM			BindingDB
Receptor-type tyrosine-protein phosphatase alpha	Homo sapiens	P18433		> 40000.0 nM			NPASS
Receptor-type tyrosine-protein phosphatase epsilon	Homo sapiens	P23469		> 40000.0 nM			NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM			NPASS
SK-MEL	Homo sapiens			= 112000.0 nM			NPASS
SiHa	Homo sapiens			= 110200.0 nM			NPASS
Signal transducer and activator of transcription 3	Homo sapiens	P40763		>50000 nM\|> 50000.0 nM			BindingDB, NPASS
Receptor-type tyrosine-protein phosphatase F (LAR)	Homo sapiens	P10586		> 40000.0 nM\|= 11800.0 nM\|> 120000.0 nM\|= 22310.0 nM			NPASS
Low molecular weight phosphotyrosine protein phosphatase	Homo sapiens	P24666		21200 nM\|22900 nM\|= 22900.0 nM\|= 21200.0 nM			BindingDB, NPASS
T-cell protein-tyrosine phosphatase	Homo sapiens	P17706		= 3400.0 nM\|= 4230.0 nM\|= 4440.0 nM\|= 5.5 ug.mL-1\|= 5460.0 nM\|> 120000.0 nM\|= 1600.0 nM\|= 7860.0 nM\|= 5000.0 nM\|= 4890.0 nM\|= 6420.0 nM\|= 10550.0 nM\|= 2950.0 nM\|= 700.0 nM			NPASS
Leukocyte common antigen	Homo sapiens	P08575		= 1000.0 nM			NPASS
CAPAN-1	Homo sapiens			= 50100.0 nM			NPASS
COLO 205	Homo sapiens			> 10000.0 nM			NPASS
COLO 320	Homo sapiens			> 10000.0 nM			NPASS
Coagulation factor III	Homo sapiens	P13726		= 4.975 nM			NPASS
Cyclooxygenase-1	Homo sapiens	P23219		= 380000.0 nM			NPASS
Cyclooxygenase-1	Ovis aries	P05979		= 42000.0 nM			NPASS
Bile acid receptor FXR	Homo sapiens	Q96RI1	= 0.0 nM				NPASS
Cyclooxygenase-2	Homo sapiens	P35354		= 87000.0 nM\|= 295000.0 nM\|> 40000.0 nM			NPASS
DNA ligase 1	Homo sapiens	P18858		186000 nM\|= 85.0 ug.mL-1			BindingDB, NPASS
DNA polymerase beta	Homo sapiens	P06746		26250 nM\|24980 nM\|8800 nM\|3000 nM\|= 26250.0 nM\|= 24980.0 nM\|= 8800.0 nM\|= 3000.0 nM			BindingDB, NPASS
DNA polymerase beta	Rattus norvegicus	P06766		= 7500.0 nM\|= 3700.0 nM			NPASS
DU-145	Homo sapiens			= 124000.0 nM			NPASS
Dual specificity phosphatase Cdc25B	Homo sapiens	P30305		= 980.0 nM			NPASS
Dual specificity protein phosphatase 3	Homo sapiens	P51452		5400 nM\|= 5400.0 nM			BindingDB, NPASS
DLD-1	Homo sapiens			> 100000.0 nM\|> 200000.0 nM			NPASS
Egl nine homolog 1/Prolyl hydroxylase EGLN2/Prolyl hydroxylase EGLN3/Transmembrane prolyl 4-hydroxylase	Homo sapiens	Q96KS0\|Q9GZT9\|Q9H6Z9\|Q9NXG6	>50000 nM				BindingDB
Bel-7402	Homo sapiens			= 59940.0 nM			NPASS
B16-F10	Mus musculus			= 106400.0 nM\|= 388300.0 nM			NPASS
Liver carboxylesterase 1	Homo sapiens	P23141		100 nM			BindingDB
4T1	Mus musculus			= 514100.0 nM			NPASS
518A2	Homo sapiens		> 30000.0 nM\|= 61300.0 nM\|= 64300.0 nM				NPASS
8505C	Homo sapiens		> 30000.0 nM	> 60000.0 nM			NPASS
A-375	Homo sapiens			= 328800.0 nM			NPASS
A2780	Homo sapiens		= 14000.0 nM\|= 58200.0 nM\|> 30000.0 nM	>= 20.0 ug.mL-1\|= 8.0 ug.mL-1\|= 14000.0 nM			NPASS
BGC-823	Homo sapiens			= 2590.0 nM			NPASS
A549	Homo sapiens		> 30000.0 nM\|= 72300.0 nM\|= 64100.0 nM	> 100000.0 nM\|= 96200.0 nM\|= 209000.0 nM\|= 27000.0 nM\|> 200000.0 nM\|= 390.0 nM\|= 19940.0 nM\|= 72300.0 nM\|= 81400.0 nM\|= 16290.0 nM\|= 64260.0 nM\|= 41650.0 nM\|= 6400.0 nM			NPASS
Acetyl-CoA acetyltransferase, mitochondrial	Rattus norvegicus	P17764		77900 nM\|= 77900.0 nM			BindingDB, NPASS
Acyl coenzyme A:cholesterol acyltransferase	Homo sapiens	P23141		= 100.0 nM			NPASS
Aldo-keto reductase family 1 member B1	Homo sapiens	P15121		124000 nM			BindingDB
Aldo-keto reductase family 1 member B10	Homo sapiens	O60218		4000 nM\|90 nM\|= 4000.0 nM\|= 90.0 nM		72 nM\|= 3560.0 nM\|= 660.0 nM\|= 940.0 nM\|= 160.0 nM\|= 72.0 nM	BindingDB, NPASS
Aldose reductase	Homo sapiens	P15121		= 124000.0 nM			NPASS
B16	Mus musculus			= 4800.0 nM			NPASS
A549/TR	Homo sapiens			> 200000.0 nM			NPASS
Env polyprotein	Human immunodeficiency virus 1		>100000 nM				BindingDB
Bel7402/5-FU	Homo sapiens			> 200000.0 nM			NPASS
Epidermal growth factor receptor erbB1	Homo sapiens	P00533		> 20000.0 nM			NPASS
Human immunodeficiency virus	Human immunodeficiency virus		= 1.7 ug.mL-1				NPASS
Human immunodeficiency virus 1	Human immunodeficiency virus 1		= 10.0 nM	= 47800.0 nM\|= 21.8 ug.mL-1			NPASS
Hypoxia-inducible factor prolyl hydroxylase	Homo sapiens		> 50000.0 nM				NPASS
Influenza A virus	InflueA virus			= 72200.0 nM\|> 200000.0 nM\|= 72270.0 nM			NPASS
J774	Mus musculus			= 130500.0 nM			NPASS
J774.A1	Mus musculus			= 35200.0 nM			NPASS
Homo sapiens	Homo sapiens			= 72300.0 nM			NPASS
Jurkat	Homo sapiens		> 1000.0 nM				NPASS
K562/Adr	Homo sapiens			> 200000.0 nM			NPASS
KB	Homo sapiens			> 280000.0 nM\|> 100000.0 nM\|> 500000.0 nM\|> 10000.0 nM			NPASS
L02	Homo sapiens			> 200000.0 nM			NPASS
L5178Y	Mus musculus			> 10000.0 nM			NPASS
LN-229	Homo sapiens			> 100000.0 nM			NPASS
Leishmania donovani	Leishmadonovani			> 250000.0 nM			NPASS
K562	Homo sapiens		> 100000.0 nM	= 58130.0 nM\|> 200000.0 nM\|> 100000.0 nM			NPASS
Hepatitis C virus	Hepatitis C virus			= 10000.0 nM			NPASS
Hepatitis B virus	Hepatitis B virus			= 813600.0 nM\|= 1364500.0 nM			NPASS
HEL	Homo sapiens		> 1000.0 nM				NPASS
HepG2	Homo sapiens			= 14720.0 nM\|= 51400.0 nM\|> 280000.0 nM\|= 15900.0 nM\|= 211800.0 nM\|> 10000.0 nM\|> 100000.0 nM\|> 200000.0 nM			NPASS
Hemagglutinin	InflueA virus	B4URE7			= 10900.0 nM		NPASS
HeLa	Homo sapiens			= 31380.0 nM\|> 100000.0 nM\|= 204500.0 nM			NPASS
HT-29	Homo sapiens		> 30000.0 nM\|= 38800.0 nM\|= 44900.0 nM\|> 10000.0 nM	= 38800.0 nM\|> 100000.0 nM\|= 429900.0 nM\|> 30000.0 nM\|> 10000.0 nM			NPASS
HL60/ADR	Homo sapiens			= 28750.0 nM			NPASS
HL-60	Homo sapiens			> 50.0 ug.mL-1\|= 77480.0 nM\|= 16170.0 nM\|> 30000.0 nM\|= 14750.0 nM\|= 36400.0 nM			NPASS
HEp-2	Homo sapiens			> 500000.0 nM			NPASS
Epidermal growth factor receptor	Homo sapiens	P00533		>20000 nM			BindingDB
HEK293	Homo sapiens			= 329000.0 nM\|> 500000.0 nM			NPASS
HCT-116	Homo sapiens			= 4800.0 nM\|> 150000.0 nM\|= 32400.0 nM			NPASS
H9	Homo sapiens		= 1.7 ug.mL-1\|= 3700.0 nM	= 21.8 ug.mL-1			NPASS
Glycogen phosphorylase, muscle form	Oryctolagus cuniculus	P00489		1.4e+4 nM\|14000 nM\|22900 nM\|= 14000.0 nM\|= 22100.0 nM\|= 14125.38 nM\|= 22900.0 nM			BindingDB, NPASS
GP41	Human immunodeficiency virus 1	Q76270	> 100000.0 nM				NPASS
G-protein coupled bile acid receptor 1	Homo sapiens	Q8TDU6	2250 nM\|= 2250.0 nM				BindingDB, NPASS
FaDu	Homo sapiens		= 75400.0 nM\|= 66700.0 nM\|> 30000.0 nM				NPASS

a curated database

IMPPAT Phytochemical information:
Oleanolic acid

Bioactivity information

IMPPAT Phytochemical information: Oleanolic acid

Bioactivity information

IMPPAT Phytochemical information:
Oleanolic acid