IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
P-glycoprotein 1	Homo sapiens	P08183			= 8912.51 nM		NPASS
Nuclear receptor subfamily 0 group B member 1	Homo sapiens	P51843		>67635 nM\|> 67635.0 nM			BindingDB, NPASS
Neuraminidase	InflueA virus (strain A/Puerto Rico/8/1934 H1N1)	P03468		47100 nM\|45700 nM			BindingDB
Neuraminidase	InflueA virus (A/WSN/1933(H1N1))	P03470		33360 nM\|45700 nM\|52900 nM			BindingDB
Neuraminidase	InflueA virus (A/Puerto Rico/8/1934(H1N1))	P03468		= 11.62 ug.mL-1			NPASS
Neuraminidase	InflueA virus	B4URF0		= 45700.0 nM\|= 33360.0 nM\|= 52900.0 nM			NPASS
NON-PROTEIN TARGET			= 74400.0 nM\|= 109000.0 nM\|= 15890.0 nM	= 1870.0 nM\|= 248200.0 nM\|= 44160.0 nM\|= 49660.0 nM\|= 54270.0 nM\|= 18620.0 nM			NPASS
NCI-H1299	Homo sapiens			> 50000.0 nM			NPASS
Monoamine oxidase	Homo sapiens	P27338		= 1600.0 nM			NPASS
Mitogen-activated protein kinase 14	Homo sapiens	Q16539		3.99e+4 nM			BindingDB
Mitogen-activated protein kinase 10	Homo sapiens	P53779		1.18e+4 nM			BindingDB
MRC5	Homo sapiens			> 100000.0 nM			NPASS
MDA-MB-231	Homo sapiens			= 33000.0 nM			NPASS
MCF7	Homo sapiens			= 50320.0 nM\|= 25660.0 nM\|= 50.0 nM\|= 26900.0 nM			NPASS
Liver microsome	Rattus norvegicus			= 60.0 ug.mL-1			NPASS
HCT-116	Homo sapiens			> 100000.0 nM			NPASS
KYSE-510	Homo sapiens			= 63000.0 nM			NPASS
HCT-15	Homo sapiens			= 54430.0 nM			NPASS
HEK-293T	Homo sapiens			= 319360.0 nM			NPASS
HEK293	Homo sapiens			= 77450.0 nM			NPASS
HL-60	Homo sapiens			= 33980.0 nM			NPASS
HT-1080	Homo sapiens		= 94900.0 nM				NPASS
HT-29	Homo sapiens			= 3100.0 nM\|> 100000.0 nM\|= 19490.0 nM			NPASS
PC-3	Homo sapiens			> 50000.0 nM			NPASS
HeLa	Homo sapiens		= 111000.0 nM	>= 10000.0 nM\|= 29000.0 nM\|= 43000.0 nM\|= 10.93 ug.mL-1\|= 25050.0 nM\|= 14200.0 nM			NPASS
Histone deacetylase 6	Homo sapiens	Q9UBN7		= 534.0 nM			NPASS
Human immunodeficiency virus 1	Human immunodeficiency virus 1		>= 100000.0 nM\|= 5000.0 nM\|= 13.4 ug.mL-1				NPASS
Human immunodeficiency virus type 1 integrase	Human immunodeficiency virus 1	Q7ZJM1		> 20000.0 nM\|= 1400.0 nM			NPASS
Integrase	Human immunodeficiency virus 1			1400 nM\|>20000 nM			BindingDB
K562	Homo sapiens			> 100000.0 nM\|> 50000.0 nM			NPASS
KB	Homo sapiens			= 29600.0 nM			NPASS
HepG2	Homo sapiens			= 16500.0 nM\|> 100000.0 nM			NPASS
Lactoylglutathione lyase	Homo sapiens	Q04760				83200 nM	BindingDB
Peroxisome proliferator-activated receptor gamma	Homo sapiens	P37231				= 7860.0 nM	NPASS
Prostaglandin G/H synthase 1	Ovis aries	P05979		39300 nM			BindingDB
n.a.				> 67635.0 nM			NPASS
Xanthine dehydrogenase/oxidase	Homo sapiens	P47989		840 nM			BindingDB
Xanthine dehydrogenase/oxidase	Bos taurus	P80457		1260 nM			BindingDB
Xanthine dehydrogenase	Homo sapiens	P47989		= 840.0 nM\|= 1260.0 nM			NPASS
Xanthine dehydrogenase	Bos taurus	P80457		= 1260.0 nM			NPASS
Urease subunit beta	Helicobacter pylori (strain ATCC 700392 / 26695)	P69996		302000 nM			BindingDB
Urease subunit alpha/Urease subunit beta	Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)			= 302000.0 nM			NPASS
Tyrosine-protein kinase receptor FLT3	Homo sapiens	P36888		> 10000.0 nM			NPASS
Tyrosine-protein kinase Lck	Homo sapiens	P06239		19600 nM			BindingDB
Tyrosine-protein kinase LCK	Homo sapiens	P06239		= 5.0 ug.mL-1			NPASS
Trypanosoma brucei brucei	Trypanosoma brucei brucei			< 30000.0 nM			NPASS
Taenia crassiceps	Taecrassiceps			= 80000.0 nM			NPASS
THP-1	Homo sapiens			= 23380.0 nM			NPASS
Steroidogenic factor 1	Homo sapiens	Q13285		>67635 nM			BindingDB
Plasmodium falciparum	Plasmodium falciparum			= 29800.0 nM			NPASS
Solute carrier organic anion transporter family member 2B1	Homo sapiens	O94956		= 29000.0 nM\|= 28840.32 nM			NPASS
Sialidase 2	Homo sapiens	Q9Y3R4		= 890000.0 nM			NPASS
Serine/threonine-protein kinase pim-1	Homo sapiens	P11309		15000 nM\|15136 nM			BindingDB
Seed lipoxygenase-1	Glycine max	P08170				= 19400.0 nM	NPASS
Seed linoleate 13S-lipoxygenase-1	Glycine max	P08170				19400 nM	BindingDB
SW480	Homo sapiens			= 31080.0 nM			NPASS
SW1353	Homo sapiens			= 33000.0 nM			NPASS
SGC-7901	Homo sapiens			= 5800.0 nM\|> 100000.0 nM			NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM			NPASS
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens	P36888		>10000 nM			BindingDB
Radical scavenging activity				= 20.4 ug.mL-1			NPASS
RBL-2H3	Rattus norvegicus			> 500000.0 nM			NPASS
Proteasome subunit beta type-5	Homo sapiens	P28074		6100 nM\|4900 nM			BindingDB
Proteasome Macropain subunit MB1	Homo sapiens	P28074		= 4900.0 nM\|= 6100.0 nM			NPASS
Prostaglandin G/H synthase 2	Homo sapiens	P35354		25500 nM			BindingDB
Sialidase-2	Homo sapiens	Q9Y3R4		890000 nM			BindingDB
H9	Homo sapiens		= 5.0 ug.mL-1	= 47000.0 nM			NPASS
Cytochrome P450 2B6	Homo sapiens	P20813		>25000 nM\|> 25000.0 nM			BindingDB, NPASS
Glyoxalase I	Homo sapiens	Q04760				= 83176.38 nM	NPASS
Carbonic anhydrase VII	Homo sapiens	P43166				= 171.41 nM	NPASS
Carbonic anhydrase IX	Homo sapiens	Q16790				= 2650.0 nM\|= 2710.0 nM	NPASS
Carbonic anhydrase IV	Homo sapiens	P22748				= 537.75 nM	NPASS
Carbonic anhydrase II	Homo sapiens	P00918				= 4380.0 nM\|= 4310.0 nM\|> 10000.0 nM	NPASS
Carbonic anhydrase I	Homo sapiens	P00915				= 5490.0 nM\|= 5420.0 nM\|> 10000.0 nM	NPASS
Carbonic anhydrase 9	Homo sapiens	Q16790				2650 nM\|2710 nM	BindingDB
Carbonic anhydrase 7	Homo sapiens	P43166				171 nM	BindingDB
Carbonic anhydrase 4	Homo sapiens	P22748				538 nM	BindingDB
Carbonic anhydrase 2	Homo sapiens	P00918				>10000 nM\|4380 nM\|4310 nM	BindingDB
Carbonic anhydrase 12	Homo sapiens	O43570				35 nM\|8960 nM\|9070 nM	BindingDB
Carbonic anhydrase 1	Homo sapiens	P00915				>10000 nM\|5420 nM\|5490 nM	BindingDB
Calmodulin-1	Homo sapiens	P0DP23		33430 nM			BindingDB
Calmodulin	Homo sapiens	P62158		= 33430.0 nM			NPASS
Caco-2	Homo sapiens			= 9500.0 nM			NPASS
Carbonic anhydrase XII	Homo sapiens	O43570				= 8960.0 nM\|= 9070.0 nM\|= 34.7 nM	NPASS
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens	Q9UNQ0		1500 nM			BindingDB
Aromatase	Homo sapiens	P11511		500 nM\|1 nM\|1500 nM			BindingDB
Aldose reductase	Homo sapiens	P15121		= 8500.0 nM\|= 7780.0 nM			NPASS
Aldose reductase	Bos taurus	P16116		= 7790.0 nM			NPASS
Aldo-keto reductase family 1 member B1 [K65Q]	Bos taurus	P16116		7790 nM			BindingDB
Aldo-keto reductase family 1 member B1	Homo sapiens	P15121		7780 nM\|8500 nM			BindingDB
ATP-dependent translocase ABCB1	Homo sapiens	P08183			8913 nM		BindingDB
ATP-binding cassette sub-family G member 2	Homo sapiens	Q9UNQ0		= 1500.0 nM\|= 2600.0 nM			NPASS
A549	Homo sapiens		= 233000.0 nM	= 19880.0 nM\|> 100000.0 nM\|= 47800.0 nM\|> 50000.0 nM\|= 28000.0 nM			NPASS
A-431	Homo sapiens			= 60130.0 nM\|= 29390.0 nM			NPASS
A-375	Homo sapiens			= 29650.0 nM\|= 33230.0 nM			NPASS
3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum	Q965D6		= 10000.0 nM			NPASS
3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum			10000 nM			BindingDB
2008	Homo sapiens			= 28620.0 nM			NPASS
H22	Mus musculus			= 1671000.0 nM			NPASS
B16-F10	Mus musculus			= 17450.0 nM			NPASS
Carbonyl reductase [NADPH] 1	Homo sapiens	P16152		670 nM\|= 670.0 nM		110 nM\|= 110.0 nM	BindingDB, NPASS
Aorta	Rattus norvegicus			= 75700.0 nM\|= 106900.0 nM			NPASS
Casein kinase 2	Rattus norvegicus			= 9000.0 nM			NPASS
Glycogen synthase kinase-3 beta	Rattus norvegicus	P18266		7200 nM			BindingDB
Casein kinase 2	Homo sapiens			= 9000.0 nM			NPASS
Glycogen synthase kinase-3 beta	Homo sapiens	P49841	>300000 nM				BindingDB
Glycogen synthase kinase-3	Homo sapiens	P49841		= 7200.0 nM			NPASS
GABA-A receptor; anion channel	Rattus norvegicus	Q9ES14				= 920.0 nM	NPASS
GABA-A receptor; anion channel	Homo sapiens	Q16445				= 3019.95 nM	NPASS
Entamoeba histolytica	Eoeba histolytica			= 81.0 ug.mL-1			NPASS
Dipeptidyl peptidase 3	Homo sapiens	Q9NY33		1.231e+5 nM			BindingDB
DU-145	Homo sapiens			= 9810.0 nM			NPASS
DNA polymerase eta	Homo sapiens	Q9Y253		= 14800.0 nM			NPASS
DNA gyrase A/A/B/B tetramer	Escherichia coli (strain K12)	P0AES4\|P0AES6		>1960000 nM			BindingDB
DNA gyrase	Escherichia coli K-12	P0AES4		> 500.0 ug.mL-1			NPASS
Cytochrome P450 3A4	Homo sapiens	P08684		>50000 nM\|> 50000.0 nM			BindingDB, NPASS
Cytochrome P450 2D6	Homo sapiens	P10635		>50000 nM\|> 50000.0 nM			BindingDB, NPASS
Cytochrome P450 2C9	Homo sapiens	P11712		5225 nM\|= 5225.0 nM			BindingDB, NPASS
Death-associated protein kinase 1	Homo sapiens	P53355		>300000 nM\|> 300000.0 nM			BindingDB, NPASS
Cytochrome P450 2A6	Homo sapiens	P11509		>25000 nM\|> 25000.0 nM			BindingDB, NPASS
Casein kinase II subunit alpha 3	Homo sapiens	Q8NEV1		9000 nM			BindingDB
Chikungunya virus	Chikunguvirus			= 22500.0 nM			NPASS
Cyclin homolog/dependent kinase 6	Saimiriine herpesvirus 2 (strain 11)	Q00534\|Q01043		6000 nM			BindingDB
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B	Marthasterias glacialis	P15206\|Q9DGD3		7100 nM			BindingDB
Cyclin-dependent kinase 1/cyclin B	Homo sapiens	O95067		= 7100.0 nM			NPASS
Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Q15078		= 3100.0 nM			NPASS
Cyclin-dependent kinase 6	Homo sapiens	Q00534		6000 nM\|= 6000.0 nM			BindingDB, NPASS
Cyclin-dependent kinase 5 activator 1 [99-307]	Homo sapiens	Q00535\|Q15078		3100 nM			BindingDB
Cyclooxygenase-1	Ovis aries	P05979		= 39300.0 nM			NPASS
Cyclooxygenase-2	Homo sapiens	P35354		= 25500.0 nM			NPASS
Cytochrome P450 19A1	Homo sapiens	P11511		= 1.0 nM\|= 1500.0 nM\|= 800.0 nM\|= 500.0 nM\|= 1000.0 nM\|= 699.84 nM		= 2600.0 nM	NPASS
Cytochrome P450 1A1	Homo sapiens	P04798		153 nM\|1290 nM\|= 153.0 nM\|= 1290.0 nM		42 nM\|= 42.0 nM	BindingDB, NPASS
Cytochrome P450 1A2	Homo sapiens	P05177		84 nM\|54 nM\|570 nM\|= 84.0 nM\|= 54.0 nM\|= 570.0 nM		500 nM\|= 500.0 nM	BindingDB, NPASS
Cytochrome P450 1B1	Homo sapiens	Q16678		24 nM\|280 nM\|= 24.0 nM\|= 280.0 nM		16 nM\|= 16.0 nM	BindingDB, NPASS

a curated database

IMPPAT Phytochemical information:
Chrysin

Bioactivity information

IMPPAT Phytochemical information: Chrysin

Bioactivity information

IMPPAT Phytochemical information:
Chrysin